-- dump date 20140620_083654 -- class Genbank::misc_feature -- table misc_feature_note -- id note 760570000001 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 760570000002 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 760570000003 dimer interface [polypeptide binding]; other site 760570000004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570000005 catalytic residue [active] 760570000006 Uncharacterized conserved protein [Function unknown]; Region: COG1739 760570000007 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 760570000008 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 760570000009 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 760570000010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760570000011 ATP binding site [chemical binding]; other site 760570000012 putative Mg++ binding site [ion binding]; other site 760570000013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570000014 nucleotide binding region [chemical binding]; other site 760570000015 ATP-binding site [chemical binding]; other site 760570000016 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 760570000017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570000018 active site 760570000019 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 760570000020 30S subunit binding site; other site 760570000021 hypothetical protein; Provisional; Region: PRK13662 760570000022 RecX family; Region: RecX; cl00936 760570000023 TRAM domain; Region: TRAM; pfam01938 760570000024 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 760570000025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570000026 S-adenosylmethionine binding site [chemical binding]; other site 760570000027 potential frameshift: common BLAST hit: gi|307068682|ref|YP_003877648.1| cytidine deaminase 760570000028 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 760570000029 active site 760570000030 catalytic motif [active] 760570000031 Zn binding site [ion binding]; other site 760570000032 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 760570000033 active site 760570000034 Zn binding site [ion binding]; other site 760570000035 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 760570000036 Uncharacterized conserved protein [Function unknown]; Region: COG2461 760570000037 Family of unknown function (DUF438); Region: DUF438; pfam04282 760570000038 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 760570000039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760570000040 putative active site [active] 760570000041 heme pocket [chemical binding]; other site 760570000042 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 760570000043 hypothetical protein; Provisional; Region: PRK07758 760570000044 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 760570000045 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 760570000046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 760570000047 Coenzyme A binding pocket [chemical binding]; other site 760570000048 AAA domain; Region: AAA_18; pfam13238 760570000049 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 760570000050 active site 760570000051 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 760570000052 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760570000053 active site 760570000054 HIGH motif; other site 760570000055 nucleotide binding site [chemical binding]; other site 760570000056 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 760570000057 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 760570000058 active site 760570000059 KMSKS motif; other site 760570000060 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 760570000061 tRNA binding surface [nucleotide binding]; other site 760570000062 anticodon binding site; other site 760570000063 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 760570000064 Uncharacterized conserved protein [Function unknown]; Region: COG0398 760570000065 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 760570000066 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 760570000067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570000068 active site 760570000069 motif I; other site 760570000070 motif II; other site 760570000071 GTPase YqeH; Provisional; Region: PRK13796 760570000072 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 760570000073 GTP/Mg2+ binding site [chemical binding]; other site 760570000074 G4 box; other site 760570000075 G5 box; other site 760570000076 G1 box; other site 760570000077 Switch I region; other site 760570000078 G2 box; other site 760570000079 G3 box; other site 760570000080 Switch II region; other site 760570000081 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 760570000082 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 760570000083 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 760570000084 active site 760570000085 (T/H)XGH motif; other site 760570000086 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760570000087 Zn2+ binding site [ion binding]; other site 760570000088 Mg2+ binding site [ion binding]; other site 760570000089 Isochorismatase family; Region: Isochorismatase; pfam00857 760570000090 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 760570000091 catalytic triad [active] 760570000092 conserved cis-peptide bond; other site 760570000093 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 760570000094 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 760570000095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570000096 S-adenosylmethionine binding site [chemical binding]; other site 760570000097 hypothetical protein; Provisional; Region: PRK13670 760570000098 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 760570000099 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 760570000100 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 760570000101 hypothetical protein; Provisional; Region: PRK12378 760570000102 DNA polymerase IV; Reviewed; Region: PRK03103 760570000103 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 760570000104 active site 760570000105 DNA binding site [nucleotide binding] 760570000106 Predicted transcriptional regulator [Transcription]; Region: COG2932 760570000107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570000108 sequence-specific DNA binding site [nucleotide binding]; other site 760570000109 salt bridge; other site 760570000110 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760570000111 Catalytic site [active] 760570000112 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 760570000113 dimer interface [polypeptide binding]; other site 760570000114 active site 760570000115 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 760570000116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570000117 S-adenosylmethionine binding site [chemical binding]; other site 760570000118 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 760570000119 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 760570000120 active site 760570000121 (T/H)XGH motif; other site 760570000122 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 760570000123 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 760570000124 protein binding site [polypeptide binding]; other site 760570000125 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 760570000126 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 760570000127 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 760570000128 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760570000129 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760570000130 catalytic residues [active] 760570000131 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 760570000132 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 760570000133 SelR domain; Region: SelR; pfam01641 760570000134 Response regulator receiver domain; Region: Response_reg; pfam00072 760570000135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570000136 active site 760570000137 phosphorylation site [posttranslational modification] 760570000138 intermolecular recognition site; other site 760570000139 dimerization interface [polypeptide binding]; other site 760570000140 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760570000141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760570000142 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760570000143 Cache domain; Region: Cache_1; pfam02743 760570000144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760570000145 dimerization interface [polypeptide binding]; other site 760570000146 Histidine kinase; Region: His_kinase; pfam06580 760570000147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570000148 Mg2+ binding site [ion binding]; other site 760570000149 G-X-G motif; other site 760570000150 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 760570000151 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 760570000152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760570000153 FeS/SAM binding site; other site 760570000154 VanZ like family; Region: VanZ; pfam04892 760570000155 T-box leader; HMPREF0833_nc10002 760570000156 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 760570000157 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 760570000158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570000159 catalytic residue [active] 760570000160 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 760570000161 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 760570000162 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 760570000163 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760570000164 active site residue [active] 760570000165 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 760570000166 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 760570000167 RNA binding surface [nucleotide binding]; other site 760570000168 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 760570000169 active site 760570000170 uracil binding [chemical binding]; other site 760570000171 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 760570000172 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 760570000173 G1 box; other site 760570000174 putative GEF interaction site [polypeptide binding]; other site 760570000175 GTP/Mg2+ binding site [chemical binding]; other site 760570000176 Switch I region; other site 760570000177 G2 box; other site 760570000178 G3 box; other site 760570000179 Switch II region; other site 760570000180 G4 box; other site 760570000181 G5 box; other site 760570000182 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 760570000183 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 760570000184 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 760570000185 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 760570000186 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 760570000187 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760570000188 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760570000189 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 760570000190 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 760570000191 active site 760570000192 homodimer interface [polypeptide binding]; other site 760570000193 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 760570000194 Cell division protein FtsQ; Region: FtsQ; pfam03799 760570000195 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 760570000196 Cell division protein FtsA; Region: FtsA; smart00842 760570000197 Cell division protein FtsA; Region: FtsA; pfam14450 760570000198 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 760570000199 cell division protein FtsZ; Validated; Region: PRK09330 760570000200 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 760570000201 nucleotide binding site [chemical binding]; other site 760570000202 SulA interaction site; other site 760570000203 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 760570000204 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760570000205 catalytic residue [active] 760570000206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 760570000207 YGGT family; Region: YGGT; pfam02325 760570000208 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 760570000209 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760570000210 RNA binding surface [nucleotide binding]; other site 760570000211 DivIVA protein; Region: DivIVA; pfam05103 760570000212 DivIVA domain; Region: DivI1A_domain; TIGR03544 760570000213 T-box leader; HMPREF0833_nc10003 760570000214 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 760570000215 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760570000216 active site 760570000217 HIGH motif; other site 760570000218 nucleotide binding site [chemical binding]; other site 760570000219 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 760570000220 active site 760570000221 KMSKS motif; other site 760570000222 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 760570000223 tRNA binding surface [nucleotide binding]; other site 760570000224 anticodon binding site; other site 760570000225 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 760570000226 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 760570000227 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 760570000228 nudix motif; other site 760570000229 Predicted transcriptional regulator [Transcription]; Region: COG2378 760570000230 HTH domain; Region: HTH_11; pfam08279 760570000231 WYL domain; Region: WYL; pfam13280 760570000232 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 760570000233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570000234 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760570000235 Walker A motif; other site 760570000236 ATP binding site [chemical binding]; other site 760570000237 Walker B motif; other site 760570000238 arginine finger; other site 760570000239 UvrB/uvrC motif; Region: UVR; pfam02151 760570000240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570000241 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760570000242 Walker A motif; other site 760570000243 ATP binding site [chemical binding]; other site 760570000244 Walker B motif; other site 760570000245 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 760570000246 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 760570000247 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 760570000248 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 760570000249 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 760570000250 homodimer interface [polypeptide binding]; other site 760570000251 NADP binding site [chemical binding]; other site 760570000252 substrate binding site [chemical binding]; other site 760570000253 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 760570000254 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570000255 active site 760570000256 motif I; other site 760570000257 motif II; other site 760570000258 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 760570000259 putative substrate binding site [chemical binding]; other site 760570000260 putative ATP binding site [chemical binding]; other site 760570000261 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 760570000262 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 760570000263 substrate binding [chemical binding]; other site 760570000264 active site 760570000265 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 760570000266 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 760570000267 malate dehydrogenase; Provisional; Region: PRK13529 760570000268 Malic enzyme, N-terminal domain; Region: malic; pfam00390 760570000269 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 760570000270 NAD(P) binding site [chemical binding]; other site 760570000271 Transcriptional regulator [Transcription]; Region: LysR; COG0583 760570000272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760570000273 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 760570000274 dimerization interface [polypeptide binding]; other site 760570000275 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 760570000276 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 760570000277 generic binding surface II; other site 760570000278 generic binding surface I; other site 760570000279 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 760570000280 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 760570000281 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 760570000282 substrate binding pocket [chemical binding]; other site 760570000283 chain length determination region; other site 760570000284 substrate-Mg2+ binding site; other site 760570000285 catalytic residues [active] 760570000286 aspartate-rich region 1; other site 760570000287 active site lid residues [active] 760570000288 aspartate-rich region 2; other site 760570000289 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 760570000290 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760570000291 RNA binding surface [nucleotide binding]; other site 760570000292 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 760570000293 Arginine repressor [Transcription]; Region: ArgR; COG1438 760570000294 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 760570000295 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 760570000296 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 760570000297 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 760570000298 Walker A/P-loop; other site 760570000299 ATP binding site [chemical binding]; other site 760570000300 Q-loop/lid; other site 760570000301 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 760570000302 ABC transporter signature motif; other site 760570000303 Walker B; other site 760570000304 D-loop; other site 760570000305 H-loop/switch region; other site 760570000306 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 760570000307 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760570000308 active site 760570000309 metal binding site [ion binding]; metal-binding site 760570000310 EDD domain protein, DegV family; Region: DegV; TIGR00762 760570000311 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 760570000312 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 760570000313 IHF dimer interface [polypeptide binding]; other site 760570000314 IHF - DNA interface [nucleotide binding]; other site 760570000315 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 760570000316 metal binding site 2 [ion binding]; metal-binding site 760570000317 putative DNA binding helix; other site 760570000318 metal binding site 1 [ion binding]; metal-binding site 760570000319 dimer interface [polypeptide binding]; other site 760570000320 structural Zn2+ binding site [ion binding]; other site 760570000321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760570000322 catalytic core [active] 760570000323 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760570000324 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 760570000325 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 760570000326 active site 760570000327 HIGH motif; other site 760570000328 KMSKS motif; other site 760570000329 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 760570000330 tRNA binding surface [nucleotide binding]; other site 760570000331 anticodon binding site; other site 760570000332 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 760570000333 dimer interface [polypeptide binding]; other site 760570000334 putative tRNA-binding site [nucleotide binding]; other site 760570000335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570000336 salt bridge; other site 760570000337 non-specific DNA binding site [nucleotide binding]; other site 760570000338 sequence-specific DNA binding site [nucleotide binding]; other site 760570000339 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760570000340 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760570000341 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760570000342 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 760570000343 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 760570000344 metal binding site [ion binding]; metal-binding site 760570000345 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 760570000346 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 760570000347 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 760570000348 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 760570000349 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 760570000350 nucleophilic elbow; other site 760570000351 catalytic triad; other site 760570000352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760570000353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570000354 active site 760570000355 phosphorylation site [posttranslational modification] 760570000356 intermolecular recognition site; other site 760570000357 dimerization interface [polypeptide binding]; other site 760570000358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760570000359 DNA binding site [nucleotide binding] 760570000360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760570000361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570000362 ATP binding site [chemical binding]; other site 760570000363 Mg2+ binding site [ion binding]; other site 760570000364 G-X-G motif; other site 760570000365 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570000366 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760570000367 Walker A/P-loop; other site 760570000368 ATP binding site [chemical binding]; other site 760570000369 Q-loop/lid; other site 760570000370 ABC transporter signature motif; other site 760570000371 Walker B; other site 760570000372 D-loop; other site 760570000373 H-loop/switch region; other site 760570000374 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760570000375 FtsX-like permease family; Region: FtsX; pfam02687 760570000376 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 760570000377 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 760570000378 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 760570000379 conserved hypothetical protein; Region: TIGR02328 760570000380 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 760570000381 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 760570000382 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 760570000383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760570000384 ATP binding site [chemical binding]; other site 760570000385 putative Mg++ binding site [ion binding]; other site 760570000386 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 760570000387 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 760570000388 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760570000389 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760570000390 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 760570000391 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760570000392 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 760570000393 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 760570000394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570000395 non-specific DNA binding site [nucleotide binding]; other site 760570000396 salt bridge; other site 760570000397 sequence-specific DNA binding site [nucleotide binding]; other site 760570000398 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 760570000399 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 760570000400 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760570000401 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 760570000402 NAD binding site [chemical binding]; other site 760570000403 dimer interface [polypeptide binding]; other site 760570000404 substrate binding site [chemical binding]; other site 760570000405 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 760570000406 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760570000407 Predicted flavoprotein [General function prediction only]; Region: COG0431 760570000408 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 760570000409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570000410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760570000411 putative substrate translocation pore; other site 760570000412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570000413 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 760570000414 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 760570000415 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570000416 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760570000417 Walker A/P-loop; other site 760570000418 ATP binding site [chemical binding]; other site 760570000419 Q-loop/lid; other site 760570000420 ABC transporter signature motif; other site 760570000421 Walker B; other site 760570000422 D-loop; other site 760570000423 H-loop/switch region; other site 760570000424 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 760570000425 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 760570000426 peptide binding site [polypeptide binding]; other site 760570000427 Predicted transcriptional regulators [Transcription]; Region: COG1695 760570000428 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 760570000429 amino acid transporter; Region: 2A0306; TIGR00909 760570000430 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 760570000431 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 760570000432 classical (c) SDRs; Region: SDR_c; cd05233 760570000433 NAD(P) binding site [chemical binding]; other site 760570000434 active site 760570000435 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570000436 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760570000437 Walker A/P-loop; other site 760570000438 ATP binding site [chemical binding]; other site 760570000439 Q-loop/lid; other site 760570000440 ABC transporter signature motif; other site 760570000441 Walker B; other site 760570000442 D-loop; other site 760570000443 H-loop/switch region; other site 760570000444 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760570000445 FtsX-like permease family; Region: FtsX; pfam02687 760570000446 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 760570000447 nudix motif; other site 760570000448 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 760570000449 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 760570000450 nudix motif; other site 760570000451 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 760570000452 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 760570000453 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 760570000454 Substrate binding site; other site 760570000455 Mg++ binding site; other site 760570000456 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 760570000457 active site 760570000458 substrate binding site [chemical binding]; other site 760570000459 CoA binding site [chemical binding]; other site 760570000460 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 760570000461 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 760570000462 dimer interface [polypeptide binding]; other site 760570000463 ADP-ribose binding site [chemical binding]; other site 760570000464 active site 760570000465 nudix motif; other site 760570000466 metal binding site [ion binding]; metal-binding site 760570000467 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 760570000468 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 760570000469 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 760570000470 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 760570000471 minor groove reading motif; other site 760570000472 helix-hairpin-helix signature motif; other site 760570000473 substrate binding pocket [chemical binding]; other site 760570000474 active site 760570000475 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 760570000476 peptide binding site [polypeptide binding]; other site 760570000477 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 760570000478 pcr only sequence 760570000479 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 760570000480 dimer interface [polypeptide binding]; other site 760570000481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760570000482 ligand binding site [chemical binding]; other site 760570000483 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 760570000484 active site 760570000485 putative catalytic site [active] 760570000486 DNA binding site [nucleotide binding] 760570000487 putative phosphate binding site [ion binding]; other site 760570000488 metal binding site A [ion binding]; metal-binding site 760570000489 AP binding site [nucleotide binding]; other site 760570000490 metal binding site B [ion binding]; metal-binding site 760570000491 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 760570000492 Predicted membrane protein [Function unknown]; Region: COG2323 760570000493 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 760570000494 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 760570000495 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 760570000496 recombination protein RecR; Reviewed; Region: recR; PRK00076 760570000497 RecR protein; Region: RecR; pfam02132 760570000498 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 760570000499 putative active site [active] 760570000500 putative metal-binding site [ion binding]; other site 760570000501 tetramer interface [polypeptide binding]; other site 760570000502 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 760570000503 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 760570000504 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 760570000505 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 760570000506 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 760570000507 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760570000508 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760570000509 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 760570000510 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 760570000511 nudix motif; other site 760570000512 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 760570000513 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 760570000514 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 760570000515 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 760570000516 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 760570000517 G1 box; other site 760570000518 putative GEF interaction site [polypeptide binding]; other site 760570000519 GTP/Mg2+ binding site [chemical binding]; other site 760570000520 Switch I region; other site 760570000521 G2 box; other site 760570000522 G3 box; other site 760570000523 Switch II region; other site 760570000524 G4 box; other site 760570000525 G5 box; other site 760570000526 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 760570000527 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 760570000528 pentamer interface [polypeptide binding]; other site 760570000529 dodecaamer interface [polypeptide binding]; other site 760570000530 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 760570000531 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 760570000532 Cl binding site [ion binding]; other site 760570000533 oligomer interface [polypeptide binding]; other site 760570000534 helicase 45; Provisional; Region: PTZ00424 760570000535 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 760570000536 ATP binding site [chemical binding]; other site 760570000537 Mg++ binding site [ion binding]; other site 760570000538 motif III; other site 760570000539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570000540 nucleotide binding region [chemical binding]; other site 760570000541 ATP-binding site [chemical binding]; other site 760570000542 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 760570000543 active site 760570000544 catalytic residues [active] 760570000545 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 760570000546 GIY-YIG motif/motif A; other site 760570000547 putative active site [active] 760570000548 putative metal binding site [ion binding]; other site 760570000549 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 760570000550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570000551 S-adenosylmethionine binding site [chemical binding]; other site 760570000552 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 760570000553 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 760570000554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760570000555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570000556 motif II; other site 760570000557 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 760570000558 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 760570000559 putative acyl-acceptor binding pocket; other site 760570000560 SLBB domain; Region: SLBB; pfam10531 760570000561 comEA protein; Region: comE; TIGR01259 760570000562 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 760570000563 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 760570000564 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 760570000565 Competence protein; Region: Competence; pfam03772 760570000566 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 760570000567 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760570000568 Protein of unknown function (DUF805); Region: DUF805; pfam05656 760570000569 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 760570000570 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 760570000571 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 760570000572 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 760570000573 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 760570000574 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 760570000575 Domain of unknown function DUF87; Region: DUF87; pfam01935 760570000576 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 760570000577 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760570000578 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760570000579 ligand binding site [chemical binding]; other site 760570000580 flexible hinge region; other site 760570000581 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760570000582 putative switch regulator; other site 760570000583 non-specific DNA interactions [nucleotide binding]; other site 760570000584 DNA binding site [nucleotide binding] 760570000585 sequence specific DNA binding site [nucleotide binding]; other site 760570000586 putative cAMP binding site [chemical binding]; other site 760570000587 arginine deiminase; Provisional; Region: PRK01388 760570000588 ornithine carbamoyltransferase; Validated; Region: PRK02102 760570000589 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 760570000590 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 760570000591 carbamate kinase; Reviewed; Region: PRK12686 760570000592 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 760570000593 putative substrate binding site [chemical binding]; other site 760570000594 nucleotide binding site [chemical binding]; other site 760570000595 nucleotide binding site [chemical binding]; other site 760570000596 homodimer interface [polypeptide binding]; other site 760570000597 Predicted membrane protein [Function unknown]; Region: COG1288 760570000598 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 760570000599 hypothetical protein; Provisional; Region: PRK07205 760570000600 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 760570000601 active site 760570000602 metal binding site [ion binding]; metal-binding site 760570000603 Arginine repressor [Transcription]; Region: ArgR; COG1438 760570000604 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 760570000605 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 760570000606 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 760570000607 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 760570000608 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 760570000609 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 760570000610 active site 760570000611 trimer interface [polypeptide binding]; other site 760570000612 allosteric site; other site 760570000613 active site lid [active] 760570000614 hexamer (dimer of trimers) interface [polypeptide binding]; other site 760570000615 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 760570000616 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 760570000617 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 760570000618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570000619 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760570000620 putative substrate translocation pore; other site 760570000621 Competence protein CoiA-like family; Region: CoiA; pfam06054 760570000622 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 760570000623 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 760570000624 active site 760570000625 Zn binding site [ion binding]; other site 760570000626 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 760570000627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570000628 S-adenosylmethionine binding site [chemical binding]; other site 760570000629 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 760570000630 SurA N-terminal domain; Region: SurA_N; pfam09312 760570000631 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 760570000632 Tubby C 2; Region: Tub_2; cl02043 760570000633 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 760570000634 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 760570000635 motif 1; other site 760570000636 active site 760570000637 motif 2; other site 760570000638 motif 3; other site 760570000639 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 760570000640 DHHA1 domain; Region: DHHA1; pfam02272 760570000641 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 760570000642 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 760570000643 dimer interface [polypeptide binding]; other site 760570000644 putative radical transfer pathway; other site 760570000645 diiron center [ion binding]; other site 760570000646 tyrosyl radical; other site 760570000647 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 760570000648 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 760570000649 Class I ribonucleotide reductase; Region: RNR_I; cd01679 760570000650 active site 760570000651 dimer interface [polypeptide binding]; other site 760570000652 catalytic residues [active] 760570000653 effector binding site; other site 760570000654 R2 peptide binding site; other site 760570000655 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 760570000656 catalytic residues [active] 760570000657 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 760570000658 dimerization domain swap beta strand [polypeptide binding]; other site 760570000659 regulatory protein interface [polypeptide binding]; other site 760570000660 active site 760570000661 regulatory phosphorylation site [posttranslational modification]; other site 760570000662 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 760570000663 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 760570000664 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 760570000665 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 760570000666 glycogen branching enzyme; Provisional; Region: PRK12313 760570000667 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 760570000668 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 760570000669 active site 760570000670 catalytic site [active] 760570000671 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 760570000672 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 760570000673 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 760570000674 ligand binding site; other site 760570000675 oligomer interface; other site 760570000676 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 760570000677 dimer interface [polypeptide binding]; other site 760570000678 N-terminal domain interface [polypeptide binding]; other site 760570000679 sulfate 1 binding site; other site 760570000680 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 760570000681 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760570000682 active site 760570000683 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 760570000684 dimer interface [polypeptide binding]; other site 760570000685 N-terminal domain interface [polypeptide binding]; other site 760570000686 sulfate 1 binding site; other site 760570000687 glycogen synthase; Provisional; Region: glgA; PRK00654 760570000688 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 760570000689 ADP-binding pocket [chemical binding]; other site 760570000690 homodimer interface [polypeptide binding]; other site 760570000691 G5 domain; Region: G5; pfam07501 760570000692 G5 domain; Region: G5; pfam07501 760570000693 G5 domain; Region: G5; pfam07501 760570000694 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 760570000695 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 760570000696 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 760570000697 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 760570000698 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 760570000699 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 760570000700 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 760570000701 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 760570000702 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 760570000703 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 760570000704 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 760570000705 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 760570000706 beta subunit interaction interface [polypeptide binding]; other site 760570000707 Walker A motif; other site 760570000708 ATP binding site [chemical binding]; other site 760570000709 Walker B motif; other site 760570000710 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 760570000711 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 760570000712 core domain interface [polypeptide binding]; other site 760570000713 delta subunit interface [polypeptide binding]; other site 760570000714 epsilon subunit interface [polypeptide binding]; other site 760570000715 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 760570000716 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 760570000717 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 760570000718 alpha subunit interaction interface [polypeptide binding]; other site 760570000719 Walker A motif; other site 760570000720 ATP binding site [chemical binding]; other site 760570000721 Walker B motif; other site 760570000722 inhibitor binding site; inhibition site 760570000723 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 760570000724 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 760570000725 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 760570000726 gamma subunit interface [polypeptide binding]; other site 760570000727 epsilon subunit interface [polypeptide binding]; other site 760570000728 LBP interface [polypeptide binding]; other site 760570000729 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 760570000730 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 760570000731 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 760570000732 hinge; other site 760570000733 active site 760570000734 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 760570000735 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 760570000736 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 760570000737 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 760570000738 active site 760570000739 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 760570000740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570000741 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570000742 ABC transporter; Region: ABC_tran_2; pfam12848 760570000743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570000744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570000745 non-specific DNA binding site [nucleotide binding]; other site 760570000746 salt bridge; other site 760570000747 sequence-specific DNA binding site [nucleotide binding]; other site 760570000748 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 760570000749 H+ Antiporter protein; Region: 2A0121; TIGR00900 760570000750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570000751 putative substrate translocation pore; other site 760570000752 H+ Antiporter protein; Region: 2A0121; TIGR00900 760570000753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570000754 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 760570000755 catalytic triad [active] 760570000756 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 760570000757 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760570000758 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 760570000759 Uncharacterized conserved protein [Function unknown]; Region: COG1624 760570000760 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 760570000761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 760570000762 YbbR-like protein; Region: YbbR; pfam07949 760570000763 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 760570000764 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 760570000765 active site 760570000766 substrate binding site [chemical binding]; other site 760570000767 metal binding site [ion binding]; metal-binding site 760570000768 GTPase CgtA; Reviewed; Region: obgE; PRK12297 760570000769 GTP1/OBG; Region: GTP1_OBG; pfam01018 760570000770 Obg GTPase; Region: Obg; cd01898 760570000771 G1 box; other site 760570000772 GTP/Mg2+ binding site [chemical binding]; other site 760570000773 Switch I region; other site 760570000774 G2 box; other site 760570000775 G3 box; other site 760570000776 Switch II region; other site 760570000777 G4 box; other site 760570000778 G5 box; other site 760570000779 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 760570000780 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 760570000781 homotrimer interaction site [polypeptide binding]; other site 760570000782 putative active site [active] 760570000783 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 760570000784 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 760570000785 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 760570000786 dimer interface [polypeptide binding]; other site 760570000787 phosphate binding site [ion binding]; other site 760570000788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 760570000789 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 760570000790 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 760570000791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760570000792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760570000793 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 760570000794 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 760570000795 DNA primase; Validated; Region: dnaG; PRK05667 760570000796 CHC2 zinc finger; Region: zf-CHC2; pfam01807 760570000797 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 760570000798 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 760570000799 active site 760570000800 metal binding site [ion binding]; metal-binding site 760570000801 interdomain interaction site; other site 760570000802 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 760570000803 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 760570000804 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 760570000805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760570000806 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 760570000807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760570000808 DNA binding residues [nucleotide binding] 760570000809 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 760570000810 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 760570000811 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760570000812 Walker A/P-loop; other site 760570000813 ATP binding site [chemical binding]; other site 760570000814 Q-loop/lid; other site 760570000815 ABC transporter signature motif; other site 760570000816 Walker B; other site 760570000817 D-loop; other site 760570000818 H-loop/switch region; other site 760570000819 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 760570000820 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 760570000821 active site 760570000822 PHP Thumb interface [polypeptide binding]; other site 760570000823 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 760570000824 generic binding surface I; other site 760570000825 generic binding surface II; other site 760570000826 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 760570000827 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 760570000828 active site 760570000829 ADP/pyrophosphate binding site [chemical binding]; other site 760570000830 dimerization interface [polypeptide binding]; other site 760570000831 allosteric effector site; other site 760570000832 fructose-1,6-bisphosphate binding site; other site 760570000833 pyruvate kinase; Provisional; Region: PRK05826 760570000834 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 760570000835 domain interfaces; other site 760570000836 active site 760570000837 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 760570000838 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 760570000839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570000840 dimer interface [polypeptide binding]; other site 760570000841 conserved gate region; other site 760570000842 putative PBP binding loops; other site 760570000843 ABC-ATPase subunit interface; other site 760570000844 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570000845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570000846 Walker A/P-loop; other site 760570000847 ATP binding site [chemical binding]; other site 760570000848 Q-loop/lid; other site 760570000849 ABC transporter signature motif; other site 760570000850 Walker B; other site 760570000851 D-loop; other site 760570000852 H-loop/switch region; other site 760570000853 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 760570000854 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760570000855 substrate binding pocket [chemical binding]; other site 760570000856 membrane-bound complex binding site; other site 760570000857 hinge residues; other site 760570000858 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 760570000859 Cation efflux family; Region: Cation_efflux; pfam01545 760570000860 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 760570000861 Part of AAA domain; Region: AAA_19; pfam13245 760570000862 Family description; Region: UvrD_C_2; pfam13538 760570000863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 760570000864 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 760570000865 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 760570000866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570000867 Coenzyme A binding pocket [chemical binding]; other site 760570000868 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760570000869 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 760570000870 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 760570000871 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 760570000872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760570000873 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 760570000874 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 760570000875 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 760570000876 RNA binding site [nucleotide binding]; other site 760570000877 active site 760570000878 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 760570000879 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 760570000880 active site 760570000881 Riboflavin kinase; Region: Flavokinase; smart00904 760570000882 ArsC family; Region: ArsC; pfam03960 760570000883 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 760570000884 putative catalytic residues [active] 760570000885 hypothetical protein; Provisional; Region: PRK04387 760570000886 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 760570000887 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 760570000888 active site 760570000889 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 760570000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570000891 S-adenosylmethionine binding site [chemical binding]; other site 760570000892 Uncharacterized conserved protein [Function unknown]; Region: COG3270 760570000893 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 760570000894 PBP superfamily domain; Region: PBP_like_2; cl17296 760570000895 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 760570000896 sulfate transport protein; Provisional; Region: cysT; CHL00187 760570000897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570000898 dimer interface [polypeptide binding]; other site 760570000899 conserved gate region; other site 760570000900 putative PBP binding loops; other site 760570000901 ABC-ATPase subunit interface; other site 760570000902 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 760570000903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570000904 dimer interface [polypeptide binding]; other site 760570000905 conserved gate region; other site 760570000906 putative PBP binding loops; other site 760570000907 ABC-ATPase subunit interface; other site 760570000908 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 760570000909 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 760570000910 Walker A/P-loop; other site 760570000911 ATP binding site [chemical binding]; other site 760570000912 Q-loop/lid; other site 760570000913 ABC transporter signature motif; other site 760570000914 Walker B; other site 760570000915 D-loop; other site 760570000916 H-loop/switch region; other site 760570000917 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 760570000918 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 760570000919 Walker A/P-loop; other site 760570000920 ATP binding site [chemical binding]; other site 760570000921 Q-loop/lid; other site 760570000922 ABC transporter signature motif; other site 760570000923 Walker B; other site 760570000924 D-loop; other site 760570000925 H-loop/switch region; other site 760570000926 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 760570000927 PhoU domain; Region: PhoU; pfam01895 760570000928 PhoU domain; Region: PhoU; pfam01895 760570000929 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 760570000930 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 760570000931 Zn binding site [ion binding]; other site 760570000932 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 760570000933 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 760570000934 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760570000935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570000936 active site 760570000937 phosphorylation site [posttranslational modification] 760570000938 intermolecular recognition site; other site 760570000939 dimerization interface [polypeptide binding]; other site 760570000940 LytTr DNA-binding domain; Region: LytTR; smart00850 760570000941 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760570000942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570000943 Walker A/P-loop; other site 760570000944 ATP binding site [chemical binding]; other site 760570000945 Q-loop/lid; other site 760570000946 ABC transporter signature motif; other site 760570000947 Walker B; other site 760570000948 D-loop; other site 760570000949 H-loop/switch region; other site 760570000950 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 760570000951 BioY family; Region: BioY; pfam02632 760570000952 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760570000953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570000954 active site 760570000955 phosphorylation site [posttranslational modification] 760570000956 intermolecular recognition site; other site 760570000957 dimerization interface [polypeptide binding]; other site 760570000958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760570000959 DNA binding site [nucleotide binding] 760570000960 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760570000961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760570000962 dimer interface [polypeptide binding]; other site 760570000963 phosphorylation site [posttranslational modification] 760570000964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570000965 ATP binding site [chemical binding]; other site 760570000966 Mg2+ binding site [ion binding]; other site 760570000967 G-X-G motif; other site 760570000968 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760570000969 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 760570000970 dimer interface [polypeptide binding]; other site 760570000971 active site 760570000972 metal binding site [ion binding]; metal-binding site 760570000973 glutathione binding site [chemical binding]; other site 760570000974 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 760570000975 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 760570000976 DEAD-like helicases superfamily; Region: DEXDc; smart00487 760570000977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760570000978 ATP binding site [chemical binding]; other site 760570000979 putative Mg++ binding site [ion binding]; other site 760570000980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570000981 nucleotide binding region [chemical binding]; other site 760570000982 ATP-binding site [chemical binding]; other site 760570000983 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760570000984 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760570000985 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760570000986 UDP-glucose 4-epimerase; Region: PLN02240 760570000987 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 760570000988 NAD binding site [chemical binding]; other site 760570000989 homodimer interface [polypeptide binding]; other site 760570000990 active site 760570000991 substrate binding site [chemical binding]; other site 760570000992 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 760570000993 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 760570000994 Ligand binding site; other site 760570000995 Putative Catalytic site; other site 760570000996 DXD motif; other site 760570000997 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 760570000998 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 760570000999 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 760570001000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 760570001001 active site 760570001002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760570001003 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 760570001004 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 760570001005 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 760570001006 Ligand binding site; other site 760570001007 Putative Catalytic site; other site 760570001008 DXD motif; other site 760570001009 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 760570001010 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 760570001011 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 760570001012 NADP binding site [chemical binding]; other site 760570001013 active site 760570001014 putative substrate binding site [chemical binding]; other site 760570001015 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760570001016 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 760570001017 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 760570001018 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 760570001019 Probable Catalytic site; other site 760570001020 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 760570001021 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 760570001022 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 760570001023 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 760570001024 Walker A/P-loop; other site 760570001025 ATP binding site [chemical binding]; other site 760570001026 Q-loop/lid; other site 760570001027 ABC transporter signature motif; other site 760570001028 Walker B; other site 760570001029 D-loop; other site 760570001030 H-loop/switch region; other site 760570001031 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760570001032 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760570001033 Rhamnan synthesis protein F; Region: RgpF; pfam05045 760570001034 Sulfatase; Region: Sulfatase; pfam00884 760570001035 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 760570001036 cytidylate kinase; Provisional; Region: cmk; PRK00023 760570001037 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 760570001038 CMP-binding site; other site 760570001039 The sites determining sugar specificity; other site 760570001040 Ribosomal protein L20 leader; HMPREF0833_nc10005 760570001041 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 760570001042 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 760570001043 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 760570001044 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 760570001045 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 760570001046 23S rRNA binding site [nucleotide binding]; other site 760570001047 L21 binding site [polypeptide binding]; other site 760570001048 L13 binding site [polypeptide binding]; other site 760570001049 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 760570001050 catalytic motif [active] 760570001051 Zn binding site [ion binding]; other site 760570001052 S-adenosylmethionine synthetase; Validated; Region: PRK05250 760570001053 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 760570001054 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 760570001055 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 760570001056 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 760570001057 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 760570001058 hinge; other site 760570001059 active site 760570001060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760570001061 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760570001062 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 760570001063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760570001064 DNA-binding site [nucleotide binding]; DNA binding site 760570001065 DRTGG domain; Region: DRTGG; pfam07085 760570001066 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 760570001067 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 760570001068 active site 2 [active] 760570001069 active site 1 [active] 760570001070 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 760570001071 active site 760570001072 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 760570001073 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760570001074 MarR family; Region: MarR; pfam01047 760570001075 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 760570001076 B3/4 domain; Region: B3_4; pfam03483 760570001077 Predicted membrane protein [Function unknown]; Region: COG2246 760570001078 GtrA-like protein; Region: GtrA; pfam04138 760570001079 Predicted membrane protein [Function unknown]; Region: COG4708 760570001080 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 760570001081 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 760570001082 nucleotide binding pocket [chemical binding]; other site 760570001083 K-X-D-G motif; other site 760570001084 catalytic site [active] 760570001085 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 760570001086 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 760570001087 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 760570001088 Dimer interface [polypeptide binding]; other site 760570001089 BRCT sequence motif; other site 760570001090 putative lipid kinase; Reviewed; Region: PRK13055 760570001091 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 760570001092 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 760570001093 carbohydrate binding site [chemical binding]; other site 760570001094 pullulanase, type I; Region: pulA_typeI; TIGR02104 760570001095 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 760570001096 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 760570001097 Ca binding site [ion binding]; other site 760570001098 active site 760570001099 catalytic site [active] 760570001100 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 760570001101 Sulfatase; Region: Sulfatase; pfam00884 760570001102 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 760570001103 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 760570001104 putative RNA binding site [nucleotide binding]; other site 760570001105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570001106 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 760570001107 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 760570001108 active site 760570001109 catalytic residue [active] 760570001110 dimer interface [polypeptide binding]; other site 760570001111 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 760570001112 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 760570001113 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 760570001114 NAD(P) binding site [chemical binding]; other site 760570001115 shikimate binding site; other site 760570001116 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 760570001117 active site 760570001118 dimer interface [polypeptide binding]; other site 760570001119 metal binding site [ion binding]; metal-binding site 760570001120 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 760570001121 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 760570001122 Tetramer interface [polypeptide binding]; other site 760570001123 active site 760570001124 FMN-binding site [chemical binding]; other site 760570001125 prephenate dehydrogenase; Validated; Region: PRK08507 760570001126 Prephenate dehydrogenase; Region: PDH; pfam02153 760570001127 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 760570001128 hypothetical protein; Provisional; Region: PRK13676 760570001129 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 760570001130 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 760570001131 hinge; other site 760570001132 active site 760570001133 shikimate kinase; Reviewed; Region: aroK; PRK00131 760570001134 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 760570001135 ADP binding site [chemical binding]; other site 760570001136 magnesium binding site [ion binding]; other site 760570001137 putative shikimate binding site; other site 760570001138 prephenate dehydratase; Provisional; Region: PRK11898 760570001139 Prephenate dehydratase; Region: PDT; pfam00800 760570001140 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 760570001141 putative L-Phe binding site [chemical binding]; other site 760570001142 Transcriptional regulator [Transcription]; Region: LytR; COG1316 760570001143 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 760570001144 TRAM domain; Region: TRAM; cl01282 760570001145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570001146 S-adenosylmethionine binding site [chemical binding]; other site 760570001147 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 760570001148 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 760570001149 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 760570001150 putative active site [active] 760570001151 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 760570001152 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 760570001153 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 760570001154 putative active site [active] 760570001155 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 760570001156 beta-galactosidase; Region: BGL; TIGR03356 760570001157 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 760570001158 active site 760570001159 P-loop; other site 760570001160 phosphorylation site [posttranslational modification] 760570001161 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 760570001162 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 760570001163 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 760570001164 active site 760570001165 methionine cluster; other site 760570001166 phosphorylation site [posttranslational modification] 760570001167 metal binding site [ion binding]; metal-binding site 760570001168 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 760570001169 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 760570001170 active site 760570001171 homodimer interface [polypeptide binding]; other site 760570001172 catalytic site [active] 760570001173 TfoX N-terminal domain; Region: TfoX_N; cl17592 760570001174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570001175 Coenzyme A binding pocket [chemical binding]; other site 760570001176 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 760570001177 Phosphotransferase enzyme family; Region: APH; pfam01636 760570001178 active site 760570001179 substrate binding site [chemical binding]; other site 760570001180 ATP binding site [chemical binding]; other site 760570001181 HEAT repeats; Region: HEAT_2; pfam13646 760570001182 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 760570001183 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570001184 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570001185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570001186 Walker A/P-loop; other site 760570001187 ATP binding site [chemical binding]; other site 760570001188 Q-loop/lid; other site 760570001189 ABC transporter signature motif; other site 760570001190 Walker B; other site 760570001191 D-loop; other site 760570001192 H-loop/switch region; other site 760570001193 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760570001194 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 760570001195 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 760570001196 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 760570001197 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760570001198 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760570001199 Walker A/P-loop; other site 760570001200 ATP binding site [chemical binding]; other site 760570001201 Q-loop/lid; other site 760570001202 ABC transporter signature motif; other site 760570001203 Walker B; other site 760570001204 D-loop; other site 760570001205 H-loop/switch region; other site 760570001206 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 760570001207 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 760570001208 DNA binding residues [nucleotide binding] 760570001209 dimer interface [polypeptide binding]; other site 760570001210 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 760570001211 FtsH protease regulator HflC; Provisional; Region: PRK11029 760570001212 CAAX protease self-immunity; Region: Abi; pfam02517 760570001213 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760570001214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570001215 non-specific DNA binding site [nucleotide binding]; other site 760570001216 salt bridge; other site 760570001217 sequence-specific DNA binding site [nucleotide binding]; other site 760570001218 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760570001219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570001220 non-specific DNA binding site [nucleotide binding]; other site 760570001221 salt bridge; other site 760570001222 sequence-specific DNA binding site [nucleotide binding]; other site 760570001223 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 760570001224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760570001225 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760570001226 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 760570001227 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 760570001228 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 760570001229 homodimer interface [polypeptide binding]; other site 760570001230 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 760570001231 active site 760570001232 homodimer interface [polypeptide binding]; other site 760570001233 catalytic site [active] 760570001234 RDD family; Region: RDD; pfam06271 760570001235 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 760570001236 putative active site [active] 760570001237 nucleotide binding site [chemical binding]; other site 760570001238 nudix motif; other site 760570001239 putative metal binding site [ion binding]; other site 760570001240 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 760570001241 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 760570001242 DNA binding residues [nucleotide binding] 760570001243 dimer interface [polypeptide binding]; other site 760570001244 Fic/DOC family; Region: Fic; cl00960 760570001245 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 760570001246 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 760570001247 CAAX protease self-immunity; Region: Abi; pfam02517 760570001248 CAAX protease self-immunity; Region: Abi; cl00558 760570001249 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 760570001250 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 760570001251 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 760570001252 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 760570001253 glycerol kinase; Provisional; Region: glpK; PRK00047 760570001254 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 760570001255 N- and C-terminal domain interface [polypeptide binding]; other site 760570001256 active site 760570001257 MgATP binding site [chemical binding]; other site 760570001258 catalytic site [active] 760570001259 metal binding site [ion binding]; metal-binding site 760570001260 glycerol binding site [chemical binding]; other site 760570001261 homotetramer interface [polypeptide binding]; other site 760570001262 homodimer interface [polypeptide binding]; other site 760570001263 FBP binding site [chemical binding]; other site 760570001264 protein IIAGlc interface [polypeptide binding]; other site 760570001265 acetoin reductase; Validated; Region: PRK08643 760570001266 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 760570001267 NAD binding site [chemical binding]; other site 760570001268 homotetramer interface [polypeptide binding]; other site 760570001269 homodimer interface [polypeptide binding]; other site 760570001270 active site 760570001271 substrate binding site [chemical binding]; other site 760570001272 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 760570001273 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 760570001274 DHH family; Region: DHH; pfam01368 760570001275 DHHA1 domain; Region: DHHA1; pfam02272 760570001276 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 760570001277 LXG domain of WXG superfamily; Region: LXG; pfam04740 760570001278 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 760570001279 flavodoxin; Validated; Region: PRK07308 760570001280 hypothetical protein; Provisional; Region: PRK07248 760570001281 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 760570001282 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 760570001283 putative Cl- selectivity filter; other site 760570001284 putative pore gating glutamate residue; other site 760570001285 Ribosomal protein L19 leader; HMPREF0833_nc10006 760570001286 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 760570001287 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 760570001288 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 760570001289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760570001290 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 760570001291 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 760570001292 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 760570001293 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 760570001294 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 760570001295 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 760570001296 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 760570001297 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 760570001298 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 760570001299 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 760570001300 trmE is a tRNA modification GTPase; Region: trmE; cd04164 760570001301 G1 box; other site 760570001302 GTP/Mg2+ binding site [chemical binding]; other site 760570001303 Switch I region; other site 760570001304 G2 box; other site 760570001305 Switch II region; other site 760570001306 G3 box; other site 760570001307 G4 box; other site 760570001308 G5 box; other site 760570001309 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 760570001310 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 760570001311 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760570001312 active site 760570001313 dimer interface [polypeptide binding]; other site 760570001314 phosphopentomutase; Provisional; Region: PRK05362 760570001315 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 760570001316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 760570001317 purine nucleoside phosphorylase; Provisional; Region: PRK08202 760570001318 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 760570001319 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 760570001320 putative ion selectivity filter; other site 760570001321 putative pore gating glutamate residue; other site 760570001322 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 760570001323 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 760570001324 catalytic triad [active] 760570001325 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 760570001326 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 760570001327 NAD-dependent deacetylase; Provisional; Region: PRK00481 760570001328 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 760570001329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 760570001330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760570001331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 760570001332 dimerization interface [polypeptide binding]; other site 760570001333 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 760570001334 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 760570001335 FAD binding pocket [chemical binding]; other site 760570001336 FAD binding motif [chemical binding]; other site 760570001337 phosphate binding motif [ion binding]; other site 760570001338 beta-alpha-beta structure motif; other site 760570001339 NAD binding pocket [chemical binding]; other site 760570001340 Iron coordination center [ion binding]; other site 760570001341 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 760570001342 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 760570001343 heterodimer interface [polypeptide binding]; other site 760570001344 active site 760570001345 FMN binding site [chemical binding]; other site 760570001346 homodimer interface [polypeptide binding]; other site 760570001347 substrate binding site [chemical binding]; other site 760570001348 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 760570001349 active site 760570001350 dimer interface [polypeptide binding]; other site 760570001351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570001352 active site 760570001353 conserved hypothetical integral membrane protein; Region: TIGR03766 760570001354 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 760570001355 ligand binding site [chemical binding]; other site 760570001356 active site 760570001357 UGI interface [polypeptide binding]; other site 760570001358 catalytic site [active] 760570001359 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 760570001360 putative active site [active] 760570001361 nucleotide binding site [chemical binding]; other site 760570001362 nudix motif; other site 760570001363 putative metal binding site [ion binding]; other site 760570001364 dihydroorotase; Validated; Region: pyrC; PRK09357 760570001365 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760570001366 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 760570001367 active site 760570001368 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 760570001369 active site 760570001370 catalytic triad [active] 760570001371 oxyanion hole [active] 760570001372 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 760570001373 2-isopropylmalate synthase; Validated; Region: PRK00915 760570001374 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 760570001375 active site 760570001376 catalytic residues [active] 760570001377 metal binding site [ion binding]; metal-binding site 760570001378 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 760570001379 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 760570001380 tartrate dehydrogenase; Region: TTC; TIGR02089 760570001381 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 760570001382 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 760570001383 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 760570001384 substrate binding site [chemical binding]; other site 760570001385 ligand binding site [chemical binding]; other site 760570001386 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 760570001387 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 760570001388 substrate binding site [chemical binding]; other site 760570001389 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 760570001390 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 760570001391 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 760570001392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570001393 Mg2+ binding site [ion binding]; other site 760570001394 G-X-G motif; other site 760570001395 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 760570001396 anchoring element; other site 760570001397 dimer interface [polypeptide binding]; other site 760570001398 ATP binding site [chemical binding]; other site 760570001399 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 760570001400 active site 760570001401 putative metal-binding site [ion binding]; other site 760570001402 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 760570001403 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 760570001404 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 760570001405 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 760570001406 CAP-like domain; other site 760570001407 active site 760570001408 primary dimer interface [polypeptide binding]; other site 760570001409 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760570001410 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 760570001411 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 760570001412 homodimer interface [polypeptide binding]; other site 760570001413 substrate-cofactor binding pocket; other site 760570001414 catalytic residue [active] 760570001415 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 760570001416 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 760570001417 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 760570001418 RNA binding site [nucleotide binding]; other site 760570001419 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 760570001420 RNA binding site [nucleotide binding]; other site 760570001421 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 760570001422 RNA binding site [nucleotide binding]; other site 760570001423 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 760570001424 RNA binding site [nucleotide binding]; other site 760570001425 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 760570001426 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 760570001427 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760570001428 NAD binding site [chemical binding]; other site 760570001429 dimer interface [polypeptide binding]; other site 760570001430 substrate binding site [chemical binding]; other site 760570001431 DNA gyrase subunit A; Validated; Region: PRK05560 760570001432 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 760570001433 CAP-like domain; other site 760570001434 active site 760570001435 primary dimer interface [polypeptide binding]; other site 760570001436 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760570001437 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760570001438 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760570001439 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760570001440 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760570001441 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760570001442 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 760570001443 active site 760570001444 catalytic site [active] 760570001445 hypothetical protein; Reviewed; Region: PRK00024 760570001446 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 760570001447 MPN+ (JAMM) motif; other site 760570001448 Zinc-binding site [ion binding]; other site 760570001449 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 760570001450 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 760570001451 CoA binding domain; Region: CoA_binding; pfam02629 760570001452 Putative amino acid metabolism; Region: DUF1831; pfam08866 760570001453 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 760570001454 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 760570001455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760570001456 catalytic residue [active] 760570001457 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 760570001458 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 760570001459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570001460 active site 760570001461 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 760570001462 putative active site [active] 760570001463 putative metal binding residues [ion binding]; other site 760570001464 signature motif; other site 760570001465 putative triphosphate binding site [ion binding]; other site 760570001466 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 760570001467 synthetase active site [active] 760570001468 NTP binding site [chemical binding]; other site 760570001469 metal binding site [ion binding]; metal-binding site 760570001470 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 760570001471 ATP-NAD kinase; Region: NAD_kinase; pfam01513 760570001472 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760570001473 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760570001474 active site 760570001475 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 760570001476 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 760570001477 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 760570001478 minor groove reading motif; other site 760570001479 helix-hairpin-helix signature motif; other site 760570001480 substrate binding pocket [chemical binding]; other site 760570001481 active site 760570001482 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 760570001483 DNA binding and oxoG recognition site [nucleotide binding] 760570001484 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760570001485 catalytic residues [active] 760570001486 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 760570001487 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 760570001488 active site 760570001489 substrate binding site [chemical binding]; other site 760570001490 metal binding site [ion binding]; metal-binding site 760570001491 Predicted membrane protein [Function unknown]; Region: COG4684 760570001492 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 760570001493 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 760570001494 Flavoprotein; Region: Flavoprotein; pfam02441 760570001495 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 760570001496 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 760570001497 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 760570001498 Potassium binding sites [ion binding]; other site 760570001499 Cesium cation binding sites [ion binding]; other site 760570001500 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 760570001501 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 760570001502 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 760570001503 Uncharacterized conserved protein [Function unknown]; Region: COG1434 760570001504 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 760570001505 putative active site [active] 760570001506 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 760570001507 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 760570001508 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 760570001509 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760570001510 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760570001511 catalytic residues [active] 760570001512 Predicted flavoprotein [General function prediction only]; Region: COG0431 760570001513 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760570001514 PAS domain; Region: PAS_10; pfam13596 760570001515 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760570001516 Predicted flavoprotein [General function prediction only]; Region: COG0431 760570001517 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 760570001518 ApbE family; Region: ApbE; pfam02424 760570001519 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 760570001520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760570001521 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 760570001522 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 760570001523 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 760570001524 Cl- selectivity filter; other site 760570001525 Cl- binding residues [ion binding]; other site 760570001526 pore gating glutamate residue; other site 760570001527 dimer interface [polypeptide binding]; other site 760570001528 H+/Cl- coupling transport residue; other site 760570001529 TrkA-C domain; Region: TrkA_C; pfam02080 760570001530 Imelysin; Region: Peptidase_M75; pfam09375 760570001531 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 760570001532 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 760570001533 Iron permease FTR1 family; Region: FTR1; cl00475 760570001534 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 760570001535 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 760570001536 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760570001537 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 760570001538 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 760570001539 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 760570001540 active site 760570001541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570001542 active site 760570001543 xanthine permease; Region: pbuX; TIGR03173 760570001544 Sulfate transporter family; Region: Sulfate_transp; pfam00916 760570001545 multidrug efflux protein; Reviewed; Region: PRK01766 760570001546 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 760570001547 cation binding site [ion binding]; other site 760570001548 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 760570001549 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 760570001550 active site 1 [active] 760570001551 dimer interface [polypeptide binding]; other site 760570001552 hexamer interface [polypeptide binding]; other site 760570001553 active site 2 [active] 760570001554 thymidine kinase; Provisional; Region: PRK04296 760570001555 peptide chain release factor 1; Validated; Region: prfA; PRK00591 760570001556 This domain is found in peptide chain release factors; Region: PCRF; smart00937 760570001557 RF-1 domain; Region: RF-1; pfam00472 760570001558 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 760570001559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570001560 S-adenosylmethionine binding site [chemical binding]; other site 760570001561 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 760570001562 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 760570001563 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 760570001564 dimer interface [polypeptide binding]; other site 760570001565 active site 760570001566 glycine-pyridoxal phosphate binding site [chemical binding]; other site 760570001567 folate binding site [chemical binding]; other site 760570001568 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 760570001569 Lysozyme-like; Region: Lysozyme_like; pfam13702 760570001570 catalytic residue [active] 760570001571 Predicted secreted protein [Function unknown]; Region: COG4086 760570001572 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 760570001573 GMP synthase; Reviewed; Region: guaA; PRK00074 760570001574 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 760570001575 AMP/PPi binding site [chemical binding]; other site 760570001576 candidate oxyanion hole; other site 760570001577 catalytic triad [active] 760570001578 potential glutamine specificity residues [chemical binding]; other site 760570001579 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 760570001580 ATP Binding subdomain [chemical binding]; other site 760570001581 Dimerization subdomain; other site 760570001582 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 760570001583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760570001584 DNA-binding site [nucleotide binding]; DNA binding site 760570001585 UTRA domain; Region: UTRA; pfam07702 760570001586 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 760570001587 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 760570001588 active site 760570001589 TDP-binding site; other site 760570001590 acceptor substrate-binding pocket; other site 760570001591 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760570001592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760570001593 NAD(P) binding site [chemical binding]; other site 760570001594 active site 760570001595 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 760570001596 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 760570001597 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 760570001598 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 760570001599 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 760570001600 dimer interface [polypeptide binding]; other site 760570001601 active site 760570001602 CoA binding pocket [chemical binding]; other site 760570001603 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 760570001604 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 760570001605 signal recognition particle protein; Provisional; Region: PRK10867 760570001606 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 760570001607 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 760570001608 P loop; other site 760570001609 GTP binding site [chemical binding]; other site 760570001610 Signal peptide binding domain; Region: SRP_SPB; pfam02978 760570001611 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 760570001612 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 760570001613 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 760570001614 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760570001615 active site 760570001616 DNA binding site [nucleotide binding] 760570001617 Int/Topo IB signature motif; other site 760570001618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570001619 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 760570001620 Walker A/P-loop; other site 760570001621 ATP binding site [chemical binding]; other site 760570001622 Q-loop/lid; other site 760570001623 ABC transporter signature motif; other site 760570001624 Walker B; other site 760570001625 D-loop; other site 760570001626 H-loop/switch region; other site 760570001627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 760570001628 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 760570001629 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 760570001630 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 760570001631 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 760570001632 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 760570001633 E3 interaction surface; other site 760570001634 lipoyl attachment site [posttranslational modification]; other site 760570001635 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 760570001636 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 760570001637 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760570001638 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 760570001639 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 760570001640 e3 binding domain; Region: E3_binding; pfam02817 760570001641 e3 binding domain; Region: E3_binding; pfam02817 760570001642 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 760570001643 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 760570001644 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 760570001645 alpha subunit interface [polypeptide binding]; other site 760570001646 TPP binding site [chemical binding]; other site 760570001647 heterodimer interface [polypeptide binding]; other site 760570001648 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 760570001649 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 760570001650 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 760570001651 tetramer interface [polypeptide binding]; other site 760570001652 TPP-binding site [chemical binding]; other site 760570001653 heterodimer interface [polypeptide binding]; other site 760570001654 phosphorylation loop region [posttranslational modification] 760570001655 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 760570001656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 760570001657 Putative esterase; Region: Esterase; pfam00756 760570001658 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760570001659 Putative esterase; Region: Esterase; pfam00756 760570001660 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 760570001661 Glucose inhibited division protein A; Region: GIDA; pfam01134 760570001662 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 760570001663 DNA topoisomerase I; Validated; Region: PRK05582 760570001664 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 760570001665 active site 760570001666 interdomain interaction site; other site 760570001667 putative metal-binding site [ion binding]; other site 760570001668 nucleotide binding site [chemical binding]; other site 760570001669 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 760570001670 domain I; other site 760570001671 DNA binding groove [nucleotide binding] 760570001672 phosphate binding site [ion binding]; other site 760570001673 domain II; other site 760570001674 domain III; other site 760570001675 nucleotide binding site [chemical binding]; other site 760570001676 catalytic site [active] 760570001677 domain IV; other site 760570001678 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 760570001679 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 760570001680 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 760570001681 DNA protecting protein DprA; Region: dprA; TIGR00732 760570001682 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760570001683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760570001684 nucleotide binding site [chemical binding]; other site 760570001685 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 760570001686 RNA/DNA hybrid binding site [nucleotide binding]; other site 760570001687 active site 760570001688 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 760570001689 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 760570001690 GTP/Mg2+ binding site [chemical binding]; other site 760570001691 G4 box; other site 760570001692 G5 box; other site 760570001693 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 760570001694 G1 box; other site 760570001695 G1 box; other site 760570001696 GTP/Mg2+ binding site [chemical binding]; other site 760570001697 Switch I region; other site 760570001698 G2 box; other site 760570001699 G2 box; other site 760570001700 G3 box; other site 760570001701 G3 box; other site 760570001702 Switch II region; other site 760570001703 Switch II region; other site 760570001704 G4 box; other site 760570001705 ATP cone domain; Region: ATP-cone; pfam03477 760570001706 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 760570001707 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 760570001708 dimer interface [polypeptide binding]; other site 760570001709 active site 760570001710 catalytic residue [active] 760570001711 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 760570001712 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 760570001713 LemA family; Region: LemA; cl00742 760570001714 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 760570001715 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 760570001716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570001717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 760570001718 Coenzyme A binding pocket [chemical binding]; other site 760570001719 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570001720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570001721 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760570001722 Walker A/P-loop; other site 760570001723 ATP binding site [chemical binding]; other site 760570001724 Q-loop/lid; other site 760570001725 ABC transporter signature motif; other site 760570001726 Walker B; other site 760570001727 D-loop; other site 760570001728 H-loop/switch region; other site 760570001729 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570001730 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570001731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570001732 Walker A/P-loop; other site 760570001733 ATP binding site [chemical binding]; other site 760570001734 Q-loop/lid; other site 760570001735 ABC transporter signature motif; other site 760570001736 Walker B; other site 760570001737 D-loop; other site 760570001738 H-loop/switch region; other site 760570001739 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760570001740 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 760570001741 Int/Topo IB signature motif; other site 760570001742 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 760570001743 DNA primase, catalytic core; Region: dnaG; TIGR01391 760570001744 CHC2 zinc finger; Region: zf-CHC2; cl17510 760570001745 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 760570001746 active site 760570001747 metal binding site [ion binding]; metal-binding site 760570001748 interdomain interaction site; other site 760570001749 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 760570001750 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 760570001751 Walker A motif; other site 760570001752 ATP binding site [chemical binding]; other site 760570001753 Walker B motif; other site 760570001754 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760570001755 agmatine deiminase; Provisional; Region: PRK13551 760570001756 agmatine deiminase; Region: agmatine_aguA; TIGR03380 760570001757 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 760570001758 putrescine carbamoyltransferase; Provisional; Region: PRK02255 760570001759 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 760570001760 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 760570001761 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760570001762 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760570001763 DNA binding residues [nucleotide binding] 760570001764 dimerization interface [polypeptide binding]; other site 760570001765 serine/threonine-protein kinase 1; Provisional; Region: pk1; PHA03390 760570001766 Catalytic domain of Protein Kinases; Region: PKc; cd00180 760570001767 active site 760570001768 ATP binding site [chemical binding]; other site 760570001769 substrate binding site [chemical binding]; other site 760570001770 activation loop (A-loop); other site 760570001771 potential frameshift: common BLAST hit: gi|325956045|ref|YP_004286655.1| putative type II restriction endonuclease 760570001772 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 760570001773 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760570001774 Levivirus coat protein; Region: Levi_coat; cl17566 760570001775 Double zinc ribbon; Region: DZR; pfam12773 760570001776 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 760570001777 Peptidase family M48; Region: Peptidase_M48; cl12018 760570001778 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 760570001779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570001780 non-specific DNA binding site [nucleotide binding]; other site 760570001781 salt bridge; other site 760570001782 sequence-specific DNA binding site [nucleotide binding]; other site 760570001783 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760570001784 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 760570001785 intersubunit interface [polypeptide binding]; other site 760570001786 active site 760570001787 Zn2+ binding site [ion binding]; other site 760570001788 L-rhamnose isomerase; Provisional; Region: PRK01076 760570001789 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 760570001790 potential frameshift: common BLAST hit: gi|46909037|ref|YP_015426.1| rhamnulokinase 760570001791 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 760570001792 nucleotide binding site [chemical binding]; other site 760570001793 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 760570001794 nucleotide binding site [chemical binding]; other site 760570001795 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760570001796 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760570001797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760570001798 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 760570001799 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 760570001800 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 760570001801 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 760570001802 MFS/sugar transport protein; Region: MFS_2; pfam13347 760570001803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570001804 putative substrate translocation pore; other site 760570001805 Cupin domain; Region: Cupin_2; pfam07883 760570001806 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760570001807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760570001808 beta-phosphoglucomutase; Region: bPGM; TIGR01990 760570001809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570001810 motif II; other site 760570001811 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 760570001812 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 760570001813 metal binding site [ion binding]; metal-binding site 760570001814 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 760570001815 core dimer interface [polypeptide binding]; other site 760570001816 L10 interface [polypeptide binding]; other site 760570001817 L11 interface [polypeptide binding]; other site 760570001818 putative EF-Tu interaction site [polypeptide binding]; other site 760570001819 putative EF-G interaction site [polypeptide binding]; other site 760570001820 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 760570001821 23S rRNA interface [nucleotide binding]; other site 760570001822 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 760570001823 Ribosomal protein L10 leader; HMPREF0833_nc10009 760570001824 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 760570001825 pcr only sequence 760570001826 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 760570001827 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 760570001828 G1 box; other site 760570001829 GTP/Mg2+ binding site [chemical binding]; other site 760570001830 Switch I region; other site 760570001831 G2 box; other site 760570001832 G3 box; other site 760570001833 Switch II region; other site 760570001834 G4 box; other site 760570001835 G5 box; other site 760570001836 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 760570001837 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 760570001838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570001839 Walker A motif; other site 760570001840 ATP binding site [chemical binding]; other site 760570001841 Walker B motif; other site 760570001842 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 760570001843 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 760570001844 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 760570001845 folate binding site [chemical binding]; other site 760570001846 NADP+ binding site [chemical binding]; other site 760570001847 thymidylate synthase; Reviewed; Region: thyA; PRK01827 760570001848 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 760570001849 dimerization interface [polypeptide binding]; other site 760570001850 active site 760570001851 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 760570001852 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760570001853 nucleotide binding site [chemical binding]; other site 760570001854 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 760570001855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570001856 Walker A/P-loop; other site 760570001857 ATP binding site [chemical binding]; other site 760570001858 Q-loop/lid; other site 760570001859 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570001860 ABC transporter; Region: ABC_tran_2; pfam12848 760570001861 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570001862 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 760570001863 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 760570001864 active site 760570001865 NTP binding site [chemical binding]; other site 760570001866 metal binding triad [ion binding]; metal-binding site 760570001867 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 760570001868 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 760570001869 dihydrodipicolinate reductase; Provisional; Region: PRK00048 760570001870 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 760570001871 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 760570001872 EDD domain protein, DegV family; Region: DegV; TIGR00762 760570001873 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 760570001874 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 760570001875 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 760570001876 active site 760570001877 phosphorylation site [posttranslational modification] 760570001878 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 760570001879 active site 760570001880 P-loop; other site 760570001881 phosphorylation site [posttranslational modification] 760570001882 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 760570001883 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 760570001884 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 760570001885 putative substrate binding site [chemical binding]; other site 760570001886 putative ATP binding site [chemical binding]; other site 760570001887 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 760570001888 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 760570001889 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 760570001890 Cysteine-rich secretory protein family; Region: CAP; pfam00188 760570001891 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 760570001892 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 760570001893 RimM N-terminal domain; Region: RimM; pfam01782 760570001894 PRC-barrel domain; Region: PRC; pfam05239 760570001895 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760570001896 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 760570001897 metal binding site [ion binding]; metal-binding site 760570001898 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 760570001899 KH domain; Region: KH_4; pfam13083 760570001900 G-X-X-G motif; other site 760570001901 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 760570001902 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 760570001903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570001904 motif II; other site 760570001905 Flagellin N-methylase; Region: FliB; pfam03692 760570001906 GTP-binding protein LepA; Provisional; Region: PRK05433 760570001907 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 760570001908 G1 box; other site 760570001909 putative GEF interaction site [polypeptide binding]; other site 760570001910 GTP/Mg2+ binding site [chemical binding]; other site 760570001911 Switch I region; other site 760570001912 G2 box; other site 760570001913 G3 box; other site 760570001914 Switch II region; other site 760570001915 G4 box; other site 760570001916 G5 box; other site 760570001917 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 760570001918 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 760570001919 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 760570001920 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 760570001921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570001922 Coenzyme A binding pocket [chemical binding]; other site 760570001923 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760570001924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570001925 non-specific DNA binding site [nucleotide binding]; other site 760570001926 salt bridge; other site 760570001927 sequence-specific DNA binding site [nucleotide binding]; other site 760570001928 Predicted transcriptional regulator [Transcription]; Region: COG2932 760570001929 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760570001930 Catalytic site [active] 760570001931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570001932 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 760570001933 active site 760570001934 motif I; other site 760570001935 motif II; other site 760570001936 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 760570001937 peptidase T; Region: peptidase-T; TIGR01882 760570001938 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 760570001939 metal binding site [ion binding]; metal-binding site 760570001940 dimer interface [polypeptide binding]; other site 760570001941 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 760570001942 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760570001943 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 760570001944 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 760570001945 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 760570001946 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 760570001947 catalytic site [active] 760570001948 subunit interface [polypeptide binding]; other site 760570001949 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 760570001950 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 760570001951 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 760570001952 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 760570001953 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570001954 active site 760570001955 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 760570001956 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 760570001957 PhnA protein; Region: PhnA; pfam03831 760570001958 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 760570001959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570001960 motif II; other site 760570001961 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 760570001962 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 760570001963 CoenzymeA binding site [chemical binding]; other site 760570001964 subunit interaction site [polypeptide binding]; other site 760570001965 PHB binding site; other site 760570001966 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760570001967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570001968 Walker A/P-loop; other site 760570001969 ATP binding site [chemical binding]; other site 760570001970 Q-loop/lid; other site 760570001971 ABC transporter signature motif; other site 760570001972 Walker B; other site 760570001973 D-loop; other site 760570001974 H-loop/switch region; other site 760570001975 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 760570001976 putative active site [active] 760570001977 nucleotide binding site [chemical binding]; other site 760570001978 nudix motif; other site 760570001979 putative metal binding site [ion binding]; other site 760570001980 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 760570001981 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760570001982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 760570001983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570001984 Coenzyme A binding pocket [chemical binding]; other site 760570001985 excinuclease ABC subunit B; Provisional; Region: PRK05298 760570001986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760570001987 ATP binding site [chemical binding]; other site 760570001988 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570001989 nucleotide binding region [chemical binding]; other site 760570001990 ATP-binding site [chemical binding]; other site 760570001991 Ultra-violet resistance protein B; Region: UvrB; pfam12344 760570001992 UvrB/uvrC motif; Region: UVR; pfam02151 760570001993 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760570001994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570001995 Walker A/P-loop; other site 760570001996 ATP binding site [chemical binding]; other site 760570001997 Q-loop/lid; other site 760570001998 ABC transporter signature motif; other site 760570001999 Walker B; other site 760570002000 D-loop; other site 760570002001 H-loop/switch region; other site 760570002002 potential frameshift: common BLAST hit: gi|289167181|ref|YP_003445448.1| response regulator 760570002003 Response regulator receiver domain; Region: Response_reg; pfam00072 760570002004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570002005 active site 760570002006 phosphorylation site [posttranslational modification] 760570002007 intermolecular recognition site; other site 760570002008 dimerization interface [polypeptide binding]; other site 760570002009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760570002010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760570002011 DNA binding site [nucleotide binding] 760570002012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760570002013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760570002014 dimer interface [polypeptide binding]; other site 760570002015 phosphorylation site [posttranslational modification] 760570002016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570002017 ATP binding site [chemical binding]; other site 760570002018 Mg2+ binding site [ion binding]; other site 760570002019 G-X-G motif; other site 760570002020 CAAX protease self-immunity; Region: Abi; pfam02517 760570002021 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 760570002022 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760570002023 substrate binding pocket [chemical binding]; other site 760570002024 membrane-bound complex binding site; other site 760570002025 hinge residues; other site 760570002026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760570002027 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 760570002028 substrate binding pocket [chemical binding]; other site 760570002029 membrane-bound complex binding site; other site 760570002030 hinge residues; other site 760570002031 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 760570002032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570002033 dimer interface [polypeptide binding]; other site 760570002034 conserved gate region; other site 760570002035 putative PBP binding loops; other site 760570002036 ABC-ATPase subunit interface; other site 760570002037 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 760570002038 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 760570002039 Walker A/P-loop; other site 760570002040 ATP binding site [chemical binding]; other site 760570002041 Q-loop/lid; other site 760570002042 ABC transporter signature motif; other site 760570002043 Walker B; other site 760570002044 D-loop; other site 760570002045 H-loop/switch region; other site 760570002046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570002047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570002048 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760570002049 Walker A/P-loop; other site 760570002050 ATP binding site [chemical binding]; other site 760570002051 Q-loop/lid; other site 760570002052 ABC transporter signature motif; other site 760570002053 Walker B; other site 760570002054 D-loop; other site 760570002055 H-loop/switch region; other site 760570002056 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570002057 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570002058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570002059 Walker A/P-loop; other site 760570002060 ATP binding site [chemical binding]; other site 760570002061 Q-loop/lid; other site 760570002062 ABC transporter signature motif; other site 760570002063 Walker B; other site 760570002064 D-loop; other site 760570002065 H-loop/switch region; other site 760570002066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570002067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760570002068 putative substrate translocation pore; other site 760570002069 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 760570002070 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 760570002071 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 760570002072 putative dimer interface [polypeptide binding]; other site 760570002073 putative anticodon binding site; other site 760570002074 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 760570002075 homodimer interface [polypeptide binding]; other site 760570002076 motif 1; other site 760570002077 motif 2; other site 760570002078 active site 760570002079 motif 3; other site 760570002080 aspartate aminotransferase; Provisional; Region: PRK05764 760570002081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760570002082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570002083 homodimer interface [polypeptide binding]; other site 760570002084 catalytic residue [active] 760570002085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 760570002086 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 760570002087 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760570002088 MarR family; Region: MarR; pfam01047 760570002089 hypothetical protein; Validated; Region: PRK02101 760570002090 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 760570002091 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 760570002092 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 760570002093 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 760570002094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760570002095 DNA-binding site [nucleotide binding]; DNA binding site 760570002096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760570002097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570002098 homodimer interface [polypeptide binding]; other site 760570002099 catalytic residue [active] 760570002100 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570002101 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570002102 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760570002103 Walker A/P-loop; other site 760570002104 ATP binding site [chemical binding]; other site 760570002105 Q-loop/lid; other site 760570002106 ABC transporter signature motif; other site 760570002107 Walker B; other site 760570002108 D-loop; other site 760570002109 H-loop/switch region; other site 760570002110 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570002111 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 760570002112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570002113 Walker A/P-loop; other site 760570002114 ATP binding site [chemical binding]; other site 760570002115 Q-loop/lid; other site 760570002116 ABC transporter signature motif; other site 760570002117 Walker B; other site 760570002118 D-loop; other site 760570002119 H-loop/switch region; other site 760570002120 Protein of unknown function (DUF419); Region: DUF419; cl15265 760570002121 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 760570002122 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760570002123 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 760570002124 TM-ABC transporter signature motif; other site 760570002125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760570002126 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 760570002127 TM-ABC transporter signature motif; other site 760570002128 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 760570002129 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760570002130 Walker A/P-loop; other site 760570002131 ATP binding site [chemical binding]; other site 760570002132 Q-loop/lid; other site 760570002133 ABC transporter signature motif; other site 760570002134 Walker B; other site 760570002135 D-loop; other site 760570002136 H-loop/switch region; other site 760570002137 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760570002138 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 760570002139 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 760570002140 ligand binding site [chemical binding]; other site 760570002141 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 760570002142 active site 760570002143 catalytic motif [active] 760570002144 Zn binding site [ion binding]; other site 760570002145 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 760570002146 intersubunit interface [polypeptide binding]; other site 760570002147 active site 760570002148 catalytic residue [active] 760570002149 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 760570002150 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 760570002151 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 760570002152 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 760570002153 Methyltransferase domain; Region: Methyltransf_31; pfam13847 760570002154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570002155 S-adenosylmethionine binding site [chemical binding]; other site 760570002156 pantothenate kinase; Provisional; Region: PRK05439 760570002157 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 760570002158 ATP-binding site [chemical binding]; other site 760570002159 CoA-binding site [chemical binding]; other site 760570002160 Mg2+-binding site [ion binding]; other site 760570002161 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 760570002162 topology modulation protein; Provisional; Region: PRK07261 760570002163 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 760570002164 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 760570002165 Predicted membrane protein [Function unknown]; Region: COG4640 760570002166 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760570002167 active site residue [active] 760570002168 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 760570002169 putative deacylase active site [active] 760570002170 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 760570002171 putative uracil binding site [chemical binding]; other site 760570002172 putative active site [active] 760570002173 dipeptidase PepV; Reviewed; Region: PRK07318 760570002174 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 760570002175 active site 760570002176 metal binding site [ion binding]; metal-binding site 760570002177 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 760570002178 dimer interface [polypeptide binding]; other site 760570002179 FMN binding site [chemical binding]; other site 760570002180 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 760570002181 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760570002182 active site 760570002183 metal binding site [ion binding]; metal-binding site 760570002184 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 760570002185 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 760570002186 GIY-YIG motif/motif A; other site 760570002187 active site 760570002188 catalytic site [active] 760570002189 putative DNA binding site [nucleotide binding]; other site 760570002190 metal binding site [ion binding]; metal-binding site 760570002191 UvrB/uvrC motif; Region: UVR; pfam02151 760570002192 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 760570002193 CAAX protease self-immunity; Region: Abi; pfam02517 760570002194 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 760570002195 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 760570002196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570002197 active site 760570002198 motif I; other site 760570002199 motif II; other site 760570002200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570002201 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 760570002202 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 760570002203 active site 760570002204 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 760570002205 active site 2 [active] 760570002206 active site 1 [active] 760570002207 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 760570002208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760570002209 FeS/SAM binding site; other site 760570002210 HemN C-terminal domain; Region: HemN_C; pfam06969 760570002211 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 760570002212 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570002213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570002214 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 760570002215 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 760570002216 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 760570002217 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 760570002218 putative catalytic cysteine [active] 760570002219 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 760570002220 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 760570002221 nucleotide binding site [chemical binding]; other site 760570002222 homotetrameric interface [polypeptide binding]; other site 760570002223 putative phosphate binding site [ion binding]; other site 760570002224 putative allosteric binding site; other site 760570002225 PUA domain; Region: PUA; pfam01472 760570002226 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760570002227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760570002228 RNA binding surface [nucleotide binding]; other site 760570002229 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760570002230 active site 760570002231 lipoprotein signal peptidase; Provisional; Region: PRK14797 760570002232 Transcriptional regulator [Transcription]; Region: LysR; COG0583 760570002233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760570002234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 760570002235 dimerization interface [polypeptide binding]; other site 760570002236 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 760570002237 beta-galactosidase; Region: BGL; TIGR03356 760570002238 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 760570002239 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 760570002240 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 760570002241 active site 760570002242 P-loop; other site 760570002243 phosphorylation site [posttranslational modification] 760570002244 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 760570002245 methionine cluster; other site 760570002246 active site 760570002247 phosphorylation site [posttranslational modification] 760570002248 metal binding site [ion binding]; metal-binding site 760570002249 CAT RNA binding domain; Region: CAT_RBD; smart01061 760570002250 transcriptional antiterminator BglG; Provisional; Region: PRK09772 760570002251 PRD domain; Region: PRD; pfam00874 760570002252 PRD domain; Region: PRD; pfam00874 760570002253 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 760570002254 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 760570002255 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 760570002256 putative substrate binding site [chemical binding]; other site 760570002257 putative ATP binding site [chemical binding]; other site 760570002258 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 760570002259 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 760570002260 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 760570002261 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 760570002262 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 760570002263 active site 760570002264 P-loop; other site 760570002265 phosphorylation site [posttranslational modification] 760570002266 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 760570002267 active site 760570002268 phosphorylation site [posttranslational modification] 760570002269 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 760570002270 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 760570002271 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 760570002272 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 760570002273 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 760570002274 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 760570002275 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 760570002276 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760570002277 active site 760570002278 metal binding site [ion binding]; metal-binding site 760570002279 PEP synthetase regulatory protein; Provisional; Region: PRK05339 760570002280 HTH domain; Region: HTH_11; pfam08279 760570002281 FOG: CBS domain [General function prediction only]; Region: COG0517 760570002282 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 760570002283 pyruvate phosphate dikinase; Provisional; Region: PRK09279 760570002284 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 760570002285 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 760570002286 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 760570002287 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 760570002288 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 760570002289 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 760570002290 Ligand Binding Site [chemical binding]; other site 760570002291 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 760570002292 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 760570002293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760570002294 catalytic residue [active] 760570002295 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 760570002296 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 760570002297 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 760570002298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570002299 dimer interface [polypeptide binding]; other site 760570002300 conserved gate region; other site 760570002301 ABC-ATPase subunit interface; other site 760570002302 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 760570002303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570002304 dimer interface [polypeptide binding]; other site 760570002305 conserved gate region; other site 760570002306 putative PBP binding loops; other site 760570002307 ABC-ATPase subunit interface; other site 760570002308 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 760570002309 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 760570002310 Walker A/P-loop; other site 760570002311 ATP binding site [chemical binding]; other site 760570002312 Q-loop/lid; other site 760570002313 ABC transporter signature motif; other site 760570002314 Walker B; other site 760570002315 D-loop; other site 760570002316 H-loop/switch region; other site 760570002317 TOBE domain; Region: TOBE_2; pfam08402 760570002318 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 760570002319 FAD binding domain; Region: FAD_binding_4; pfam01565 760570002320 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 760570002321 homoserine kinase; Provisional; Region: PRK01212 760570002322 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 760570002323 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 760570002324 homoserine dehydrogenase; Provisional; Region: PRK06349 760570002325 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 760570002326 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 760570002327 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 760570002328 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 760570002329 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 760570002330 putative active site [active] 760570002331 putative metal binding site [ion binding]; other site 760570002332 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 760570002333 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760570002334 Zn2+ binding site [ion binding]; other site 760570002335 Mg2+ binding site [ion binding]; other site 760570002336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760570002337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760570002338 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 760570002339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 760570002340 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 760570002341 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760570002342 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760570002343 Walker A/P-loop; other site 760570002344 ATP binding site [chemical binding]; other site 760570002345 Q-loop/lid; other site 760570002346 ABC transporter signature motif; other site 760570002347 Walker B; other site 760570002348 D-loop; other site 760570002349 H-loop/switch region; other site 760570002350 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760570002351 metal binding site [ion binding]; metal-binding site 760570002352 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 760570002353 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 760570002354 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 760570002355 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 760570002356 active site 760570002357 Na/Ca binding site [ion binding]; other site 760570002358 catalytic site [active] 760570002359 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 760570002360 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760570002361 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760570002362 catalytic residues [active] 760570002363 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760570002364 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 760570002365 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570002366 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 760570002367 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 760570002368 peptide binding site [polypeptide binding]; other site 760570002369 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 760570002370 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 760570002371 putative oligomer interface [polypeptide binding]; other site 760570002372 putative active site [active] 760570002373 metal binding site [ion binding]; metal-binding site 760570002374 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 760570002375 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 760570002376 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570002377 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 760570002378 Walker A/P-loop; other site 760570002379 ATP binding site [chemical binding]; other site 760570002380 Q-loop/lid; other site 760570002381 ABC transporter signature motif; other site 760570002382 Walker B; other site 760570002383 D-loop; other site 760570002384 H-loop/switch region; other site 760570002385 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 760570002386 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 760570002387 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 760570002388 NAD binding site [chemical binding]; other site 760570002389 homodimer interface [polypeptide binding]; other site 760570002390 active site 760570002391 substrate binding site [chemical binding]; other site 760570002392 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 760570002393 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 760570002394 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 760570002395 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 760570002396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570002397 motif II; other site 760570002398 galactokinase; Provisional; Region: PRK05322 760570002399 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 760570002400 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 760570002401 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 760570002402 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 760570002403 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 760570002404 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570002405 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 760570002406 Melibiase; Region: Melibiase; pfam02065 760570002407 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 760570002408 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 760570002409 active site 760570002410 homodimer interface [polypeptide binding]; other site 760570002411 catalytic site [active] 760570002412 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760570002413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570002414 dimer interface [polypeptide binding]; other site 760570002415 conserved gate region; other site 760570002416 putative PBP binding loops; other site 760570002417 ABC-ATPase subunit interface; other site 760570002418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570002419 dimer interface [polypeptide binding]; other site 760570002420 conserved gate region; other site 760570002421 putative PBP binding loops; other site 760570002422 ABC-ATPase subunit interface; other site 760570002423 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760570002424 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760570002425 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 760570002426 Melibiase; Region: Melibiase; pfam02065 760570002427 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760570002428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760570002429 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760570002430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760570002431 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 760570002432 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760570002433 DNA binding site [nucleotide binding] 760570002434 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 760570002435 putative dimerization interface [polypeptide binding]; other site 760570002436 putative ligand binding site [chemical binding]; other site 760570002437 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 760570002438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760570002439 DNA-binding site [nucleotide binding]; DNA binding site 760570002440 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 760570002441 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 760570002442 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760570002443 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760570002444 FtsX-like permease family; Region: FtsX; pfam02687 760570002445 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570002446 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760570002447 Walker A/P-loop; other site 760570002448 ATP binding site [chemical binding]; other site 760570002449 Q-loop/lid; other site 760570002450 ABC transporter signature motif; other site 760570002451 Walker B; other site 760570002452 D-loop; other site 760570002453 H-loop/switch region; other site 760570002454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760570002455 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760570002456 dimerization interface [polypeptide binding]; other site 760570002457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760570002458 dimer interface [polypeptide binding]; other site 760570002459 phosphorylation site [posttranslational modification] 760570002460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570002461 ATP binding site [chemical binding]; other site 760570002462 Mg2+ binding site [ion binding]; other site 760570002463 G-X-G motif; other site 760570002464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760570002465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570002466 active site 760570002467 phosphorylation site [posttranslational modification] 760570002468 intermolecular recognition site; other site 760570002469 dimerization interface [polypeptide binding]; other site 760570002470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760570002471 DNA binding site [nucleotide binding] 760570002472 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760570002473 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760570002474 FtsX-like permease family; Region: FtsX; pfam02687 760570002475 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570002476 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760570002477 Walker A/P-loop; other site 760570002478 ATP binding site [chemical binding]; other site 760570002479 Q-loop/lid; other site 760570002480 ABC transporter signature motif; other site 760570002481 Walker B; other site 760570002482 D-loop; other site 760570002483 H-loop/switch region; other site 760570002484 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760570002485 FtsX-like permease family; Region: FtsX; pfam02687 760570002486 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 760570002487 Helix-turn-helix domain; Region: HTH_38; pfam13936 760570002488 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 760570002489 Integrase core domain; Region: rve; pfam00665 760570002490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 760570002491 Transposase; Region: DDE_Tnp_ISL3; pfam01610 760570002492 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 760570002493 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 760570002494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570002495 Walker A motif; other site 760570002496 ATP binding site [chemical binding]; other site 760570002497 Walker B motif; other site 760570002498 arginine finger; other site 760570002499 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 760570002500 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 760570002501 Predicted membrane protein [Function unknown]; Region: COG3619 760570002502 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 760570002503 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 760570002504 Sugar specificity; other site 760570002505 Pyrimidine base specificity; other site 760570002506 ATP-binding site [chemical binding]; other site 760570002507 Predicted flavoprotein [General function prediction only]; Region: COG0431 760570002508 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760570002509 FMN-binding domain; Region: FMN_bind; cl01081 760570002510 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 760570002511 L-aspartate oxidase; Provisional; Region: PRK06175 760570002512 Predicted flavoprotein [General function prediction only]; Region: COG0431 760570002513 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760570002514 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 760570002515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570002516 putative substrate translocation pore; other site 760570002517 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760570002518 Helix-turn-helix domain; Region: HTH_18; pfam12833 760570002519 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760570002520 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 760570002521 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 760570002522 NAD binding site [chemical binding]; other site 760570002523 substrate binding site [chemical binding]; other site 760570002524 homodimer interface [polypeptide binding]; other site 760570002525 active site 760570002526 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 760570002527 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 760570002528 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 760570002529 substrate binding site; other site 760570002530 tetramer interface; other site 760570002531 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 760570002532 ZIP Zinc transporter; Region: Zip; pfam02535 760570002533 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 760570002534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760570002535 Uncharacterized conserved protein [Function unknown]; Region: COG0327 760570002536 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 760570002537 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 760570002538 Family of unknown function (DUF633); Region: DUF633; pfam04816 760570002539 putative S-transferase; Provisional; Region: PRK11752 760570002540 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 760570002541 C-terminal domain interface [polypeptide binding]; other site 760570002542 GSH binding site (G-site) [chemical binding]; other site 760570002543 dimer interface [polypeptide binding]; other site 760570002544 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 760570002545 N-terminal domain interface [polypeptide binding]; other site 760570002546 dimer interface [polypeptide binding]; other site 760570002547 substrate binding pocket (H-site) [chemical binding]; other site 760570002548 adenosine deaminase; Provisional; Region: PRK09358 760570002549 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 760570002550 active site 760570002551 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 760570002552 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583 760570002553 putative active site [active] 760570002554 catalytic site [active] 760570002555 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 760570002556 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 760570002557 Homoserine O-succinyltransferase; Region: HTS; pfam04204 760570002558 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 760570002559 proposed active site lysine [active] 760570002560 conserved cys residue [active] 760570002561 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570002562 active site 760570002563 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 760570002564 DHH family; Region: DHH; pfam01368 760570002565 DHHA1 domain; Region: DHHA1; pfam02272 760570002566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 760570002567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 760570002568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570002569 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 760570002570 Coenzyme A binding pocket [chemical binding]; other site 760570002571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570002572 S-adenosylmethionine binding site [chemical binding]; other site 760570002573 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 760570002574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760570002575 NAD(P) binding site [chemical binding]; other site 760570002576 active site 760570002577 ribonuclease Z; Region: RNase_Z; TIGR02651 760570002578 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 760570002579 GTPases [General function prediction only]; Region: HflX; COG2262 760570002580 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 760570002581 HflX GTPase family; Region: HflX; cd01878 760570002582 G1 box; other site 760570002583 GTP/Mg2+ binding site [chemical binding]; other site 760570002584 Switch I region; other site 760570002585 G2 box; other site 760570002586 G3 box; other site 760570002587 Switch II region; other site 760570002588 G4 box; other site 760570002589 G5 box; other site 760570002590 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 760570002591 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 760570002592 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 760570002593 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 760570002594 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 760570002595 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 760570002596 Part of AAA domain; Region: AAA_19; pfam13245 760570002597 Family description; Region: UvrD_C_2; pfam13538 760570002598 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 760570002599 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 760570002600 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 760570002601 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 760570002602 catalytic residues [active] 760570002603 dimer interface [polypeptide binding]; other site 760570002604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570002605 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570002606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570002607 Walker A/P-loop; other site 760570002608 ATP binding site [chemical binding]; other site 760570002609 Q-loop/lid; other site 760570002610 ABC transporter signature motif; other site 760570002611 Walker B; other site 760570002612 D-loop; other site 760570002613 H-loop/switch region; other site 760570002614 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570002615 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570002616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570002617 Walker A/P-loop; other site 760570002618 ATP binding site [chemical binding]; other site 760570002619 Q-loop/lid; other site 760570002620 ABC transporter signature motif; other site 760570002621 Walker B; other site 760570002622 D-loop; other site 760570002623 H-loop/switch region; other site 760570002624 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 760570002625 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 760570002626 putative active site [active] 760570002627 catalytic site [active] 760570002628 putative metal binding site [ion binding]; other site 760570002629 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 760570002630 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570002631 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760570002632 Walker A/P-loop; other site 760570002633 ATP binding site [chemical binding]; other site 760570002634 Q-loop/lid; other site 760570002635 ABC transporter signature motif; other site 760570002636 Walker B; other site 760570002637 D-loop; other site 760570002638 H-loop/switch region; other site 760570002639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760570002640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760570002641 WHG domain; Region: WHG; pfam13305 760570002642 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760570002643 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760570002644 active site 760570002645 catalytic tetrad [active] 760570002646 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 760570002647 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 760570002648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570002649 Walker A/P-loop; other site 760570002650 ATP binding site [chemical binding]; other site 760570002651 Q-loop/lid; other site 760570002652 ABC transporter signature motif; other site 760570002653 Walker B; other site 760570002654 D-loop; other site 760570002655 H-loop/switch region; other site 760570002656 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 760570002657 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 760570002658 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570002659 non-specific DNA binding site [nucleotide binding]; other site 760570002660 salt bridge; other site 760570002661 sequence-specific DNA binding site [nucleotide binding]; other site 760570002662 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 760570002663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570002664 Coenzyme A binding pocket [chemical binding]; other site 760570002665 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 760570002666 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 760570002667 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 760570002668 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 760570002669 G1 box; other site 760570002670 GTP/Mg2+ binding site [chemical binding]; other site 760570002671 Switch I region; other site 760570002672 G2 box; other site 760570002673 G3 box; other site 760570002674 Switch II region; other site 760570002675 G4 box; other site 760570002676 G5 box; other site 760570002677 Nucleoside recognition; Region: Gate; pfam07670 760570002678 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 760570002679 Nucleoside recognition; Region: Gate; pfam07670 760570002680 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 760570002681 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 760570002682 putative tRNA-binding site [nucleotide binding]; other site 760570002683 B3/4 domain; Region: B3_4; pfam03483 760570002684 tRNA synthetase B5 domain; Region: B5; smart00874 760570002685 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 760570002686 dimer interface [polypeptide binding]; other site 760570002687 motif 1; other site 760570002688 motif 3; other site 760570002689 motif 2; other site 760570002690 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 760570002691 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 760570002692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570002693 Coenzyme A binding pocket [chemical binding]; other site 760570002694 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 760570002695 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 760570002696 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 760570002697 dimer interface [polypeptide binding]; other site 760570002698 motif 1; other site 760570002699 active site 760570002700 motif 2; other site 760570002701 motif 3; other site 760570002702 Putative ParB-like nuclease; Region: ParBc_2; cl17538 760570002703 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 760570002704 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760570002705 zinc binding site [ion binding]; other site 760570002706 putative ligand binding site [chemical binding]; other site 760570002707 T-box leader; HMPREF0833_nc10011 760570002708 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 760570002709 Domain of unknown function (DUF814); Region: DUF814; pfam05670 760570002710 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 760570002711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760570002712 binding surface 760570002713 TPR motif; other site 760570002714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760570002715 binding surface 760570002716 TPR motif; other site 760570002717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760570002718 binding surface 760570002719 TPR motif; other site 760570002720 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 760570002721 Domain of unknown function DUF20; Region: UPF0118; pfam01594 760570002722 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 760570002723 enolase; Provisional; Region: eno; PRK00077 760570002724 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 760570002725 dimer interface [polypeptide binding]; other site 760570002726 metal binding site [ion binding]; metal-binding site 760570002727 substrate binding pocket [chemical binding]; other site 760570002728 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 760570002729 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 760570002730 phosphoserine phosphatase SerB; Region: serB; TIGR00338 760570002731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570002732 motif II; other site 760570002733 septation ring formation regulator EzrA; Provisional; Region: PRK04778 760570002734 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 760570002735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570002736 Mg2+ binding site [ion binding]; other site 760570002737 G-X-G motif; other site 760570002738 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 760570002739 anchoring element; other site 760570002740 dimer interface [polypeptide binding]; other site 760570002741 ATP binding site [chemical binding]; other site 760570002742 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 760570002743 active site 760570002744 putative metal-binding site [ion binding]; other site 760570002745 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 760570002746 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 760570002747 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570002748 motif II; other site 760570002749 DJ-1 family protein; Region: not_thiJ; TIGR01383 760570002750 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 760570002751 conserved cys residue [active] 760570002752 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 760570002753 Predicted membrane protein [Function unknown]; Region: COG2855 760570002754 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 760570002755 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 760570002756 active site 760570002757 catalytic site [active] 760570002758 substrate binding site [chemical binding]; other site 760570002759 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 760570002760 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 760570002761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760570002762 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 760570002763 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 760570002764 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 760570002765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570002766 Walker A/P-loop; other site 760570002767 ATP binding site [chemical binding]; other site 760570002768 Q-loop/lid; other site 760570002769 ABC transporter signature motif; other site 760570002770 Walker B; other site 760570002771 D-loop; other site 760570002772 H-loop/switch region; other site 760570002773 peptide chain release factor 2; Validated; Region: prfB; PRK00578 760570002774 This domain is found in peptide chain release factors; Region: PCRF; smart00937 760570002775 RF-1 domain; Region: RF-1; pfam00472 760570002776 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760570002777 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 760570002778 active site 760570002779 metal binding site [ion binding]; metal-binding site 760570002780 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760570002781 active site 760570002782 metal binding site [ion binding]; metal-binding site 760570002783 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 760570002784 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 760570002785 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760570002786 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 760570002787 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 760570002788 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 760570002789 yybP-ykoY leader; HMPREF0833_nc10012 760570002790 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 760570002791 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 760570002792 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760570002793 Zn2+ binding site [ion binding]; other site 760570002794 Mg2+ binding site [ion binding]; other site 760570002795 sugar phosphate phosphatase; Provisional; Region: PRK10513 760570002796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570002797 active site 760570002798 motif I; other site 760570002799 motif II; other site 760570002800 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 760570002801 FemAB family; Region: FemAB; pfam02388 760570002802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 760570002803 FemAB family; Region: FemAB; pfam02388 760570002804 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 760570002805 triosephosphate isomerase; Provisional; Region: PRK14567 760570002806 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 760570002807 substrate binding site [chemical binding]; other site 760570002808 dimer interface [polypeptide binding]; other site 760570002809 catalytic triad [active] 760570002810 elongation factor Tu; Reviewed; Region: PRK00049 760570002811 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 760570002812 G1 box; other site 760570002813 GEF interaction site [polypeptide binding]; other site 760570002814 GTP/Mg2+ binding site [chemical binding]; other site 760570002815 Switch I region; other site 760570002816 G2 box; other site 760570002817 G3 box; other site 760570002818 Switch II region; other site 760570002819 G4 box; other site 760570002820 G5 box; other site 760570002821 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 760570002822 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 760570002823 Antibiotic Binding Site [chemical binding]; other site 760570002824 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 760570002825 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 760570002826 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 760570002827 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 760570002828 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 760570002829 active site 760570002830 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 760570002831 putative deacylase active site [active] 760570002832 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760570002833 catalytic core [active] 760570002834 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 760570002835 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 760570002836 dimer interface [polypeptide binding]; other site 760570002837 putative anticodon binding site; other site 760570002838 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 760570002839 motif 1; other site 760570002840 active site 760570002841 motif 2; other site 760570002842 motif 3; other site 760570002843 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760570002844 FtsX-like permease family; Region: FtsX; pfam02687 760570002845 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570002846 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760570002847 Walker A/P-loop; other site 760570002848 ATP binding site [chemical binding]; other site 760570002849 Q-loop/lid; other site 760570002850 ABC transporter signature motif; other site 760570002851 Walker B; other site 760570002852 D-loop; other site 760570002853 H-loop/switch region; other site 760570002854 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760570002855 HlyD family secretion protein; Region: HlyD_3; pfam13437 760570002856 glutathione reductase; Validated; Region: PRK06116 760570002857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760570002858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760570002859 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 760570002860 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 760570002861 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 760570002862 substrate binding site [chemical binding]; other site 760570002863 THF binding site; other site 760570002864 zinc-binding site [ion binding]; other site 760570002865 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 760570002866 Predicted transcriptional regulators [Transcription]; Region: COG1733 760570002867 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 760570002868 Pseudomonas avirulence D protein (AvrD); Region: AvrD; pfam05655 760570002869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570002870 D-galactonate transporter; Region: 2A0114; TIGR00893 760570002871 putative substrate translocation pore; other site 760570002872 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 760570002873 Peptidase family U32; Region: Peptidase_U32; pfam01136 760570002874 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 760570002875 Peptidase family U32; Region: Peptidase_U32; pfam01136 760570002876 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 760570002877 YtxH-like protein; Region: YtxH; pfam12732 760570002878 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 760570002879 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 760570002880 HPr kinase/phosphorylase; Provisional; Region: PRK05428 760570002881 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 760570002882 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 760570002883 Hpr binding site; other site 760570002884 active site 760570002885 homohexamer subunit interaction site [polypeptide binding]; other site 760570002886 PspC domain; Region: PspC; pfam04024 760570002887 hypothetical protein; Provisional; Region: PRK04351 760570002888 SprT homologues; Region: SprT; cl01182 760570002889 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 760570002890 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 760570002891 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 760570002892 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 760570002893 RNA binding site [nucleotide binding]; other site 760570002894 Predicted permeases [General function prediction only]; Region: COG0701 760570002895 Predicted membrane protein [Function unknown]; Region: COG3689 760570002896 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 760570002897 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 760570002898 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 760570002899 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 760570002900 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 760570002901 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 760570002902 P loop; other site 760570002903 GTP binding site [chemical binding]; other site 760570002904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570002905 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 760570002906 active site 760570002907 motif I; other site 760570002908 motif II; other site 760570002909 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 760570002910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570002911 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 760570002912 active site 760570002913 motif I; other site 760570002914 motif II; other site 760570002915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570002916 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 760570002917 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 760570002918 Walker A/P-loop; other site 760570002919 ATP binding site [chemical binding]; other site 760570002920 Q-loop/lid; other site 760570002921 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 760570002922 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 760570002923 ABC transporter signature motif; other site 760570002924 Walker B; other site 760570002925 D-loop; other site 760570002926 H-loop/switch region; other site 760570002927 ribonuclease III; Reviewed; Region: rnc; PRK00102 760570002928 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 760570002929 dimerization interface [polypeptide binding]; other site 760570002930 active site 760570002931 metal binding site [ion binding]; metal-binding site 760570002932 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 760570002933 dsRNA binding site [nucleotide binding]; other site 760570002934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 760570002935 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 760570002936 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 760570002937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 760570002938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760570002939 putative active site [active] 760570002940 heme pocket [chemical binding]; other site 760570002941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760570002942 dimer interface [polypeptide binding]; other site 760570002943 phosphorylation site [posttranslational modification] 760570002944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570002945 ATP binding site [chemical binding]; other site 760570002946 Mg2+ binding site [ion binding]; other site 760570002947 G-X-G motif; other site 760570002948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760570002949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570002950 active site 760570002951 phosphorylation site [posttranslational modification] 760570002952 intermolecular recognition site; other site 760570002953 dimerization interface [polypeptide binding]; other site 760570002954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760570002955 DNA binding site [nucleotide binding] 760570002956 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 760570002957 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 760570002958 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 760570002959 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 760570002960 active site 760570002961 dimer interface [polypeptide binding]; other site 760570002962 motif 1; other site 760570002963 motif 2; other site 760570002964 motif 3; other site 760570002965 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 760570002966 anticodon binding site; other site 760570002967 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760570002968 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 760570002969 putative ADP-binding pocket [chemical binding]; other site 760570002970 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760570002971 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 760570002972 catabolite control protein A; Region: ccpA; TIGR01481 760570002973 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760570002974 DNA binding site [nucleotide binding] 760570002975 domain linker motif; other site 760570002976 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 760570002977 dimerization interface [polypeptide binding]; other site 760570002978 effector binding site; other site 760570002979 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 760570002980 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 760570002981 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 760570002982 active site 760570002983 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570002984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 760570002985 Predicted transcriptional regulator [Transcription]; Region: COG1959 760570002986 Transcriptional regulator; Region: Rrf2; pfam02082 760570002987 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760570002988 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760570002989 active site 760570002990 metal binding site [ion binding]; metal-binding site 760570002991 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 760570002992 FtsX-like permease family; Region: FtsX; pfam02687 760570002993 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760570002994 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760570002995 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570002996 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760570002997 Walker A/P-loop; other site 760570002998 ATP binding site [chemical binding]; other site 760570002999 Q-loop/lid; other site 760570003000 ABC transporter signature motif; other site 760570003001 Walker B; other site 760570003002 D-loop; other site 760570003003 H-loop/switch region; other site 760570003004 manganese transport protein MntH; Reviewed; Region: PRK00701 760570003005 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 760570003006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760570003007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760570003008 tellurite resistance protein TehB; Provisional; Region: PRK12335 760570003009 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 760570003010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570003011 S-adenosylmethionine binding site [chemical binding]; other site 760570003012 Peptidase family C69; Region: Peptidase_C69; cl17793 760570003013 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 760570003014 SmpB-tmRNA interface; other site 760570003015 ribonuclease R; Region: RNase_R; TIGR02063 760570003016 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 760570003017 RNB domain; Region: RNB; pfam00773 760570003018 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 760570003019 RNA binding site [nucleotide binding]; other site 760570003020 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 760570003021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570003022 putative substrate translocation pore; other site 760570003023 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 760570003024 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 760570003025 CoA-binding site [chemical binding]; other site 760570003026 ATP-binding [chemical binding]; other site 760570003027 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 760570003028 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 760570003029 DNA binding site [nucleotide binding] 760570003030 catalytic residue [active] 760570003031 H2TH interface [polypeptide binding]; other site 760570003032 putative catalytic residues [active] 760570003033 turnover-facilitating residue; other site 760570003034 intercalation triad [nucleotide binding]; other site 760570003035 8OG recognition residue [nucleotide binding]; other site 760570003036 putative reading head residues; other site 760570003037 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 760570003038 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 760570003039 GTPase Era; Reviewed; Region: era; PRK00089 760570003040 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 760570003041 G1 box; other site 760570003042 GTP/Mg2+ binding site [chemical binding]; other site 760570003043 Switch I region; other site 760570003044 G2 box; other site 760570003045 Switch II region; other site 760570003046 G3 box; other site 760570003047 G4 box; other site 760570003048 G5 box; other site 760570003049 KH domain; Region: KH_2; pfam07650 760570003050 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 760570003051 metal-binding heat shock protein; Provisional; Region: PRK00016 760570003052 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570003053 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570003054 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760570003055 Walker A/P-loop; other site 760570003056 ATP binding site [chemical binding]; other site 760570003057 Q-loop/lid; other site 760570003058 ABC transporter signature motif; other site 760570003059 Walker B; other site 760570003060 D-loop; other site 760570003061 H-loop/switch region; other site 760570003062 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570003063 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570003064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570003065 Walker A/P-loop; other site 760570003066 ATP binding site [chemical binding]; other site 760570003067 Q-loop/lid; other site 760570003068 ABC transporter signature motif; other site 760570003069 Walker B; other site 760570003070 D-loop; other site 760570003071 H-loop/switch region; other site 760570003072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760570003073 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760570003074 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 760570003075 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 760570003076 hexamer interface [polypeptide binding]; other site 760570003077 ligand binding site [chemical binding]; other site 760570003078 putative active site [active] 760570003079 NAD(P) binding site [chemical binding]; other site 760570003080 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 760570003081 PhoH-like protein; Region: PhoH; pfam02562 760570003082 hypothetical protein; Provisional; Region: PRK13672 760570003083 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 760570003084 S1 domain; Region: S1_2; pfam13509 760570003085 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 760570003086 ribosome recycling factor; Reviewed; Region: frr; PRK00083 760570003087 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 760570003088 hinge region; other site 760570003089 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 760570003090 putative nucleotide binding site [chemical binding]; other site 760570003091 uridine monophosphate binding site [chemical binding]; other site 760570003092 homohexameric interface [polypeptide binding]; other site 760570003093 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 760570003094 serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224 760570003095 Unresolvable tandem repeat 760570003096 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 760570003097 mRNA/rRNA interface [nucleotide binding]; other site 760570003098 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 760570003099 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 760570003100 23S rRNA interface [nucleotide binding]; other site 760570003101 L7/L12 interface [polypeptide binding]; other site 760570003102 putative thiostrepton binding site; other site 760570003103 L25 interface [polypeptide binding]; other site 760570003104 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 760570003105 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760570003106 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 760570003107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570003108 motif II; other site 760570003109 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 760570003110 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 760570003111 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760570003112 active site 760570003113 metal binding site [ion binding]; metal-binding site 760570003114 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 760570003115 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 760570003116 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 760570003117 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 760570003118 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 760570003119 active site 760570003120 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 760570003121 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570003122 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570003123 ABC transporter; Region: ABC_tran_2; pfam12848 760570003124 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570003125 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 760570003126 ArsC family; Region: ArsC; pfam03960 760570003127 putative ArsC-like catalytic residues; other site 760570003128 putative TRX-like catalytic residues [active] 760570003129 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 760570003130 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 760570003131 DNA binding site [nucleotide binding] 760570003132 active site 760570003133 Predicted methyltransferases [General function prediction only]; Region: COG0313 760570003134 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 760570003135 putative SAM binding site [chemical binding]; other site 760570003136 putative homodimer interface [polypeptide binding]; other site 760570003137 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 760570003138 DNA polymerase III subunit delta'; Validated; Region: PRK07276 760570003139 DNA polymerase III subunit delta'; Validated; Region: PRK08485 760570003140 thymidylate kinase; Validated; Region: tmk; PRK00698 760570003141 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 760570003142 TMP-binding site; other site 760570003143 ATP-binding site [chemical binding]; other site 760570003144 Uncharacterized conserved protein [Function unknown]; Region: COG1284 760570003145 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 760570003146 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 760570003147 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 760570003148 FOG: CBS domain [General function prediction only]; Region: COG0517 760570003149 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 760570003150 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 760570003151 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 760570003152 Walker A/P-loop; other site 760570003153 ATP binding site [chemical binding]; other site 760570003154 Q-loop/lid; other site 760570003155 ABC transporter signature motif; other site 760570003156 Walker B; other site 760570003157 D-loop; other site 760570003158 H-loop/switch region; other site 760570003159 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 760570003160 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 760570003161 Walker A/P-loop; other site 760570003162 ATP binding site [chemical binding]; other site 760570003163 Q-loop/lid; other site 760570003164 ABC transporter signature motif; other site 760570003165 Walker B; other site 760570003166 D-loop; other site 760570003167 H-loop/switch region; other site 760570003168 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 760570003169 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 760570003170 TM-ABC transporter signature motif; other site 760570003171 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760570003172 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 760570003173 TM-ABC transporter signature motif; other site 760570003174 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 760570003175 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 760570003176 putative ligand binding site [chemical binding]; other site 760570003177 hypothetical protein; Provisional; Region: PRK02302 760570003178 Clp protease; Region: CLP_protease; pfam00574 760570003179 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 760570003180 oligomer interface [polypeptide binding]; other site 760570003181 active site residues [active] 760570003182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570003183 active site 760570003184 magnesium-transporting ATPase; Provisional; Region: PRK15122 760570003185 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 760570003186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760570003187 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 760570003188 Soluble P-type ATPase [General function prediction only]; Region: COG4087 760570003189 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 760570003190 ykoK leader; HMPREF0833_nc10013 760570003191 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 760570003192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760570003193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570003194 homodimer interface [polypeptide binding]; other site 760570003195 catalytic residue [active] 760570003196 cystathionine gamma-synthase; Reviewed; Region: PRK07269 760570003197 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 760570003198 homodimer interface [polypeptide binding]; other site 760570003199 substrate-cofactor binding pocket; other site 760570003200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570003201 catalytic residue [active] 760570003202 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 760570003203 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 760570003204 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 760570003205 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 760570003206 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760570003207 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760570003208 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 760570003209 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 760570003210 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 760570003211 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 760570003212 DHH family; Region: DHH; pfam01368 760570003213 DHHA2 domain; Region: DHHA2; pfam02833 760570003214 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 760570003215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760570003216 FeS/SAM binding site; other site 760570003217 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 760570003218 generic binding surface I; other site 760570003219 generic binding surface II; other site 760570003220 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 760570003221 putative catalytic site [active] 760570003222 putative metal binding site [ion binding]; other site 760570003223 putative phosphate binding site [ion binding]; other site 760570003224 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 760570003225 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 760570003226 Ca binding site [ion binding]; other site 760570003227 active site 760570003228 catalytic site [active] 760570003229 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 760570003230 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 760570003231 active site turn [active] 760570003232 phosphorylation site [posttranslational modification] 760570003233 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 760570003234 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 760570003235 HPr interaction site; other site 760570003236 glycerol kinase (GK) interaction site [polypeptide binding]; other site 760570003237 active site 760570003238 phosphorylation site [posttranslational modification] 760570003239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760570003240 DNA-binding site [nucleotide binding]; DNA binding site 760570003241 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 760570003242 UTRA domain; Region: UTRA; pfam07702 760570003243 Transposase IS200 like; Region: Y1_Tnp; pfam01797 760570003244 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 760570003245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570003246 Walker A/P-loop; other site 760570003247 ATP binding site [chemical binding]; other site 760570003248 Q-loop/lid; other site 760570003249 ABC transporter signature motif; other site 760570003250 Walker B; other site 760570003251 D-loop; other site 760570003252 H-loop/switch region; other site 760570003253 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760570003254 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 760570003255 TM-ABC transporter signature motif; other site 760570003256 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 760570003257 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760570003258 zinc binding site [ion binding]; other site 760570003259 putative ligand binding site [chemical binding]; other site 760570003260 Domain of unknown function DUF21; Region: DUF21; pfam01595 760570003261 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 760570003262 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 760570003263 Transporter associated domain; Region: CorC_HlyC; pfam03471 760570003264 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 760570003265 Mga helix-turn-helix domain; Region: Mga; pfam05043 760570003266 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 760570003267 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 760570003268 Domain of unknown function DUF20; Region: UPF0118; pfam01594 760570003269 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 760570003270 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760570003271 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 760570003272 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 760570003273 AAA domain; Region: AAA_25; pfam13481 760570003274 Walker A motif; other site 760570003275 ATP binding site [chemical binding]; other site 760570003276 Walker B motif; other site 760570003277 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 760570003278 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 760570003279 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760570003280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570003281 non-specific DNA binding site [nucleotide binding]; other site 760570003282 salt bridge; other site 760570003283 sequence-specific DNA binding site [nucleotide binding]; other site 760570003284 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760570003285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570003286 sequence-specific DNA binding site [nucleotide binding]; other site 760570003287 salt bridge; other site 760570003288 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 760570003289 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 760570003290 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 760570003291 Int/Topo IB signature motif; other site 760570003292 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 760570003293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570003294 Walker A/P-loop; other site 760570003295 ATP binding site [chemical binding]; other site 760570003296 Q-loop/lid; other site 760570003297 ABC transporter signature motif; other site 760570003298 Walker B; other site 760570003299 D-loop; other site 760570003300 H-loop/switch region; other site 760570003301 Collagen binding domain; Region: Collagen_bind; pfam05737 760570003302 Cna protein B-type domain; Region: Cna_B; pfam05738 760570003303 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 760570003304 domain interaction interfaces [polypeptide binding]; other site 760570003305 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 760570003306 domain interaction interfaces [polypeptide binding]; other site 760570003307 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 760570003308 domain interaction interfaces [polypeptide binding]; other site 760570003309 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 760570003310 domain interaction interfaces [polypeptide binding]; other site 760570003311 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570003312 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 760570003313 Transposase; Region: DDE_Tnp_ISL3; pfam01610 760570003314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 760570003315 Transposase; Region: DDE_Tnp_ISL3; pfam01610 760570003316 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 760570003317 T surface-antigen of pili; Region: FctA; pfam12892 760570003318 T surface-antigen of pili; Region: FctA; pfam12892 760570003319 T surface-antigen of pili; Region: FctA; pfam12892 760570003320 T surface-antigen of pili; Region: FctA; pfam12892 760570003321 T surface-antigen of pili; Region: FctA; pfam12892 760570003322 T surface-antigen of pili; Region: FctA; pfam12892 760570003323 T surface-antigen of pili; Region: FctA; pfam12892 760570003324 T surface-antigen of pili; Region: FctA; pfam12892 760570003325 Unresolvable tandem repeat 760570003326 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 760570003327 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 760570003328 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 760570003329 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 760570003330 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 760570003331 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 760570003332 active site 760570003333 Predicted membrane protein [Function unknown]; Region: COG3601 760570003334 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 760570003335 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 760570003336 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 760570003337 TrkA-N domain; Region: TrkA_N; pfam02254 760570003338 TrkA-C domain; Region: TrkA_C; pfam02080 760570003339 TrkA-N domain; Region: TrkA_N; pfam02254 760570003340 TrkA-C domain; Region: TrkA_C; pfam02080 760570003341 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 760570003342 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 760570003343 hypothetical protein; Validated; Region: PRK00041 760570003344 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 760570003345 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760570003346 RNA binding surface [nucleotide binding]; other site 760570003347 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 760570003348 active site 760570003349 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 760570003350 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 760570003351 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 760570003352 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760570003353 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 760570003354 DNA binding site [nucleotide binding] 760570003355 Int/Topo IB signature motif; other site 760570003356 active site 760570003357 catalytic residues [active] 760570003358 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 760570003359 FOG: CBS domain [General function prediction only]; Region: COG0517 760570003360 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 760570003361 active site 760570003362 metal binding site [ion binding]; metal-binding site 760570003363 homotetramer interface [polypeptide binding]; other site 760570003364 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 760570003365 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 760570003366 active site 760570003367 dimerization interface [polypeptide binding]; other site 760570003368 glutamate racemase; Provisional; Region: PRK00865 760570003369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 760570003370 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 760570003371 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 760570003372 active site 760570003373 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760570003374 substrate binding site [chemical binding]; other site 760570003375 catalytic residues [active] 760570003376 dimer interface [polypeptide binding]; other site 760570003377 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 760570003378 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 760570003379 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 760570003380 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 760570003381 Zn2+ binding site [ion binding]; other site 760570003382 Mg2+ binding site [ion binding]; other site 760570003383 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 760570003384 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 760570003385 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 760570003386 acylphosphatase; Provisional; Region: PRK14434 760570003387 OxaA-like protein precursor; Provisional; Region: PRK02463 760570003388 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 760570003389 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 760570003390 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 760570003391 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 760570003392 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 760570003393 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 760570003394 dimerization interface [polypeptide binding]; other site 760570003395 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 760570003396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570003397 Coenzyme A binding pocket [chemical binding]; other site 760570003398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570003399 Coenzyme A binding pocket [chemical binding]; other site 760570003400 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 760570003401 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 760570003402 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760570003403 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760570003404 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 760570003405 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 760570003406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760570003407 ATP binding site [chemical binding]; other site 760570003408 putative Mg++ binding site [ion binding]; other site 760570003409 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 760570003410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570003411 nucleotide binding region [chemical binding]; other site 760570003412 ATP-binding site [chemical binding]; other site 760570003413 GTP-binding protein Der; Reviewed; Region: PRK00093 760570003414 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 760570003415 G1 box; other site 760570003416 GTP/Mg2+ binding site [chemical binding]; other site 760570003417 Switch I region; other site 760570003418 G2 box; other site 760570003419 Switch II region; other site 760570003420 G3 box; other site 760570003421 G4 box; other site 760570003422 G5 box; other site 760570003423 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 760570003424 G1 box; other site 760570003425 GTP/Mg2+ binding site [chemical binding]; other site 760570003426 Switch I region; other site 760570003427 G2 box; other site 760570003428 G3 box; other site 760570003429 Switch II region; other site 760570003430 G4 box; other site 760570003431 G5 box; other site 760570003432 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 760570003433 dimer interface [polypeptide binding]; other site 760570003434 FMN binding site [chemical binding]; other site 760570003435 NADPH bind site [chemical binding]; other site 760570003436 primosomal protein DnaI; Reviewed; Region: PRK08939 760570003437 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 760570003438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570003439 Walker A motif; other site 760570003440 ATP binding site [chemical binding]; other site 760570003441 Walker B motif; other site 760570003442 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 760570003443 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 760570003444 ATP cone domain; Region: ATP-cone; pfam03477 760570003445 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 760570003446 putative catalytic site [active] 760570003447 putative metal binding site [ion binding]; other site 760570003448 putative phosphate binding site [ion binding]; other site 760570003449 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 760570003450 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 760570003451 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 760570003452 active site turn [active] 760570003453 phosphorylation site [posttranslational modification] 760570003454 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 760570003455 HPr interaction site; other site 760570003456 glycerol kinase (GK) interaction site [polypeptide binding]; other site 760570003457 active site 760570003458 phosphorylation site [posttranslational modification] 760570003459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760570003460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570003461 active site 760570003462 phosphorylation site [posttranslational modification] 760570003463 intermolecular recognition site; other site 760570003464 dimerization interface [polypeptide binding]; other site 760570003465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760570003466 DNA binding site [nucleotide binding] 760570003467 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 760570003468 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 760570003469 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 760570003470 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 760570003471 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 760570003472 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 760570003473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570003474 non-specific DNA binding site [nucleotide binding]; other site 760570003475 salt bridge; other site 760570003476 sequence-specific DNA binding site [nucleotide binding]; other site 760570003477 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 760570003478 heat shock protein HtpX; Provisional; Region: PRK04897 760570003479 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 760570003480 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 760570003481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570003482 S-adenosylmethionine binding site [chemical binding]; other site 760570003483 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760570003484 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 760570003485 substrate binding site [chemical binding]; other site 760570003486 ATP binding site [chemical binding]; other site 760570003487 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 760570003488 malonic semialdehyde reductase; Provisional; Region: PRK10538 760570003489 putative NAD(P) binding site [chemical binding]; other site 760570003490 homodimer interface [polypeptide binding]; other site 760570003491 homotetramer interface [polypeptide binding]; other site 760570003492 active site 760570003493 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 760570003494 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760570003495 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760570003496 Walker A/P-loop; other site 760570003497 ATP binding site [chemical binding]; other site 760570003498 Q-loop/lid; other site 760570003499 ABC transporter signature motif; other site 760570003500 Walker B; other site 760570003501 D-loop; other site 760570003502 H-loop/switch region; other site 760570003503 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 760570003504 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760570003505 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760570003506 Walker A/P-loop; other site 760570003507 ATP binding site [chemical binding]; other site 760570003508 Q-loop/lid; other site 760570003509 ABC transporter signature motif; other site 760570003510 Walker B; other site 760570003511 D-loop; other site 760570003512 H-loop/switch region; other site 760570003513 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 760570003514 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 760570003515 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 760570003516 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 760570003517 active site residue [active] 760570003518 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 760570003519 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760570003520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570003521 non-specific DNA binding site [nucleotide binding]; other site 760570003522 salt bridge; other site 760570003523 sequence-specific DNA binding site [nucleotide binding]; other site 760570003524 hypothetical protein; Provisional; Region: PRK13661 760570003525 Uncharacterized conserved protein [Function unknown]; Region: COG1912 760570003526 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 760570003527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570003528 dimer interface [polypeptide binding]; other site 760570003529 conserved gate region; other site 760570003530 ABC-ATPase subunit interface; other site 760570003531 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 760570003532 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 760570003533 Walker A/P-loop; other site 760570003534 ATP binding site [chemical binding]; other site 760570003535 Q-loop/lid; other site 760570003536 ABC transporter signature motif; other site 760570003537 Walker B; other site 760570003538 D-loop; other site 760570003539 H-loop/switch region; other site 760570003540 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 760570003541 hypothetical protein; Provisional; Region: PRK06446 760570003542 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 760570003543 metal binding site [ion binding]; metal-binding site 760570003544 dimer interface [polypeptide binding]; other site 760570003545 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 760570003546 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 760570003547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760570003548 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 760570003549 substrate binding pocket [chemical binding]; other site 760570003550 membrane-bound complex binding site; other site 760570003551 hinge residues; other site 760570003552 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760570003553 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 760570003554 metal binding site [ion binding]; metal-binding site 760570003555 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 760570003556 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 760570003557 EamA-like transporter family; Region: EamA; pfam00892 760570003558 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 760570003559 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 760570003560 putative NAD(P) binding site [chemical binding]; other site 760570003561 catalytic Zn binding site [ion binding]; other site 760570003562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760570003563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760570003564 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 760570003565 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 760570003566 GatB domain; Region: GatB_Yqey; pfam02637 760570003567 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 760570003568 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 760570003569 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 760570003570 Isochorismatase family; Region: Isochorismatase; pfam00857 760570003571 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 760570003572 catalytic triad [active] 760570003573 conserved cis-peptide bond; other site 760570003574 transcriptional repressor CodY; Validated; Region: PRK04158 760570003575 CodY GAF-like domain; Region: CodY; pfam06018 760570003576 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760570003577 dimerization interface [polypeptide binding]; other site 760570003578 putative Zn2+ binding site [ion binding]; other site 760570003579 putative DNA binding site [nucleotide binding]; other site 760570003580 aminotransferase AlaT; Validated; Region: PRK09265 760570003581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760570003582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570003583 homodimer interface [polypeptide binding]; other site 760570003584 catalytic residue [active] 760570003585 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760570003586 Ligand Binding Site [chemical binding]; other site 760570003587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570003588 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 760570003589 active site 760570003590 motif I; other site 760570003591 motif II; other site 760570003592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570003593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 760570003594 metal binding site [ion binding]; metal-binding site 760570003595 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 760570003596 active site 760570003597 homotetramer interface [polypeptide binding]; other site 760570003598 homodimer interface [polypeptide binding]; other site 760570003599 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 760570003600 Y-family of DNA polymerases; Region: PolY; cl12025 760570003601 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 760570003602 ssDNA binding site; other site 760570003603 generic binding surface II; other site 760570003604 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760570003605 ATP binding site [chemical binding]; other site 760570003606 putative Mg++ binding site [ion binding]; other site 760570003607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570003608 nucleotide binding region [chemical binding]; other site 760570003609 ATP-binding site [chemical binding]; other site 760570003610 alanine racemase; Reviewed; Region: alr; PRK00053 760570003611 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 760570003612 active site 760570003613 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760570003614 dimer interface [polypeptide binding]; other site 760570003615 substrate binding site [chemical binding]; other site 760570003616 catalytic residues [active] 760570003617 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 760570003618 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 760570003619 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 760570003620 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 760570003621 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 760570003622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570003623 nucleotide binding region [chemical binding]; other site 760570003624 ATP-binding site [chemical binding]; other site 760570003625 SEC-C motif; Region: SEC-C; pfam02810 760570003626 Amino acid permease; Region: AA_permease_2; pfam13520 760570003627 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 760570003628 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 760570003629 DNA binding residues [nucleotide binding] 760570003630 dimer interface [polypeptide binding]; other site 760570003631 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 760570003632 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 760570003633 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 760570003634 epoxyqueuosine reductase; Region: TIGR00276 760570003635 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 760570003636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570003637 Coenzyme A binding pocket [chemical binding]; other site 760570003638 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 760570003639 active site 760570003640 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570003641 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570003642 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760570003643 Walker A/P-loop; other site 760570003644 ATP binding site [chemical binding]; other site 760570003645 Q-loop/lid; other site 760570003646 ABC transporter signature motif; other site 760570003647 Walker B; other site 760570003648 D-loop; other site 760570003649 H-loop/switch region; other site 760570003650 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570003651 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570003652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570003653 Walker A/P-loop; other site 760570003654 ATP binding site [chemical binding]; other site 760570003655 Q-loop/lid; other site 760570003656 ABC transporter signature motif; other site 760570003657 Walker B; other site 760570003658 D-loop; other site 760570003659 H-loop/switch region; other site 760570003660 Transcriptional regulators [Transcription]; Region: MarR; COG1846 760570003661 MarR family; Region: MarR_2; pfam12802 760570003662 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 760570003663 active site 760570003664 catalytic residues [active] 760570003665 metal binding site [ion binding]; metal-binding site 760570003666 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760570003667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760570003668 nucleotide binding site [chemical binding]; other site 760570003669 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 760570003670 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 760570003671 active site turn [active] 760570003672 phosphorylation site [posttranslational modification] 760570003673 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 760570003674 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 760570003675 HPr interaction site; other site 760570003676 glycerol kinase (GK) interaction site [polypeptide binding]; other site 760570003677 active site 760570003678 phosphorylation site [posttranslational modification] 760570003679 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 760570003680 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 760570003681 substrate binding [chemical binding]; other site 760570003682 active site 760570003683 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 760570003684 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760570003685 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760570003686 DNA binding site [nucleotide binding] 760570003687 domain linker motif; other site 760570003688 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 760570003689 dimerization interface [polypeptide binding]; other site 760570003690 ligand binding site [chemical binding]; other site 760570003691 sodium binding site [ion binding]; other site 760570003692 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 760570003693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 760570003694 elongation factor P; Validated; Region: PRK00529 760570003695 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 760570003696 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 760570003697 RNA binding site [nucleotide binding]; other site 760570003698 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 760570003699 RNA binding site [nucleotide binding]; other site 760570003700 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 760570003701 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 760570003702 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 760570003703 active site 760570003704 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 760570003705 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760570003706 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760570003707 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 760570003708 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 760570003709 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 760570003710 Cl binding site [ion binding]; other site 760570003711 oligomer interface [polypeptide binding]; other site 760570003712 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 760570003713 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 760570003714 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760570003715 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760570003716 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 760570003717 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 760570003718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 760570003719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570003720 Coenzyme A binding pocket [chemical binding]; other site 760570003721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 760570003722 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 760570003723 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 760570003724 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 760570003725 dimer interface [polypeptide binding]; other site 760570003726 ssDNA binding site [nucleotide binding]; other site 760570003727 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760570003728 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 760570003729 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 760570003730 Ligand binding site; other site 760570003731 Putative Catalytic site; other site 760570003732 DXD motif; other site 760570003733 Predicted membrane protein [Function unknown]; Region: COG2246 760570003734 GtrA-like protein; Region: GtrA; pfam04138 760570003735 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 760570003736 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 760570003737 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 760570003738 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 760570003739 putative active site [active] 760570003740 catalytic triad [active] 760570003741 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 760570003742 PA/protease or protease-like domain interface [polypeptide binding]; other site 760570003743 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 760570003744 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 760570003745 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 760570003746 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570003747 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 760570003748 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 760570003749 putative active site [active] 760570003750 catalytic triad [active] 760570003751 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 760570003752 putative active site [active] 760570003753 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 760570003754 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 760570003755 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 760570003756 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 760570003757 putative active site [active] 760570003758 putative metal binding site [ion binding]; other site 760570003759 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 760570003760 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570003761 putative phosphoketolase; Provisional; Region: PRK05261 760570003762 XFP N-terminal domain; Region: XFP_N; pfam09364 760570003763 XFP C-terminal domain; Region: XFP_C; pfam09363 760570003764 imidazolonepropionase; Validated; Region: PRK09356 760570003765 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 760570003766 active site 760570003767 urocanate hydratase; Provisional; Region: PRK05414 760570003768 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 760570003769 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 760570003770 Formiminotransferase domain; Region: FTCD; pfam02971 760570003771 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 760570003772 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 760570003773 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 760570003774 Potassium binding sites [ion binding]; other site 760570003775 Cesium cation binding sites [ion binding]; other site 760570003776 HutD; Region: HutD; pfam05962 760570003777 amino acid transporter; Region: 2A0306; TIGR00909 760570003778 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 760570003779 active sites [active] 760570003780 tetramer interface [polypeptide binding]; other site 760570003781 formimidoylglutamase; Provisional; Region: PRK13775 760570003782 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 760570003783 putative active site [active] 760570003784 putative metal binding site [ion binding]; other site 760570003785 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 760570003786 AAA domain; Region: AAA_22; pfam13401 760570003787 AAA ATPase domain; Region: AAA_16; pfam13191 760570003788 Predicted ATPase [General function prediction only]; Region: COG3899 760570003789 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 760570003790 FAD binding site [chemical binding]; other site 760570003791 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 760570003792 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 760570003793 THF binding site; other site 760570003794 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 760570003795 substrate binding site [chemical binding]; other site 760570003796 THF binding site; other site 760570003797 zinc-binding site [ion binding]; other site 760570003798 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 760570003799 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 760570003800 Ca binding site [ion binding]; other site 760570003801 active site 760570003802 catalytic site [active] 760570003803 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 760570003804 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 760570003805 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 760570003806 putative active site [active] 760570003807 putative catalytic site [active] 760570003808 CAAX protease self-immunity; Region: Abi; pfam02517 760570003809 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 760570003810 TrkA-N domain; Region: TrkA_N; pfam02254 760570003811 TrkA-C domain; Region: TrkA_C; pfam02080 760570003812 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 760570003813 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 760570003814 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 760570003815 maltose O-acetyltransferase; Provisional; Region: PRK10092 760570003816 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 760570003817 active site 760570003818 substrate binding site [chemical binding]; other site 760570003819 trimer interface [polypeptide binding]; other site 760570003820 CoA binding site [chemical binding]; other site 760570003821 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 760570003822 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 760570003823 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 760570003824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570003825 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 760570003826 active site 760570003827 motif I; other site 760570003828 motif II; other site 760570003829 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 760570003830 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 760570003831 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 760570003832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 760570003833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760570003834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 760570003835 dimerization interface [polypeptide binding]; other site 760570003836 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 760570003837 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 760570003838 catalytic Zn binding site [ion binding]; other site 760570003839 NAD(P) binding site [chemical binding]; other site 760570003840 structural Zn binding site [ion binding]; other site 760570003841 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 760570003842 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 760570003843 active site 760570003844 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 760570003845 active site 760570003846 N-terminal domain interface [polypeptide binding]; other site 760570003847 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 760570003848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760570003849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760570003850 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 760570003851 Membrane transport protein; Region: Mem_trans; pfam03547 760570003852 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760570003853 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760570003854 Walker A/P-loop; other site 760570003855 ATP binding site [chemical binding]; other site 760570003856 Q-loop/lid; other site 760570003857 ABC transporter signature motif; other site 760570003858 Walker B; other site 760570003859 D-loop; other site 760570003860 H-loop/switch region; other site 760570003861 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760570003862 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760570003863 Walker A/P-loop; other site 760570003864 ATP binding site [chemical binding]; other site 760570003865 Q-loop/lid; other site 760570003866 ABC transporter signature motif; other site 760570003867 Walker B; other site 760570003868 D-loop; other site 760570003869 H-loop/switch region; other site 760570003870 Cobalt transport protein; Region: CbiQ; cl00463 760570003871 Acyltransferase family; Region: Acyl_transf_3; pfam01757 760570003872 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 760570003873 aminodeoxychorismate synthase; Provisional; Region: PRK07508 760570003874 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 760570003875 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 760570003876 substrate-cofactor binding pocket; other site 760570003877 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 760570003878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570003879 catalytic residue [active] 760570003880 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760570003881 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760570003882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570003883 Walker A/P-loop; other site 760570003884 ATP binding site [chemical binding]; other site 760570003885 Q-loop/lid; other site 760570003886 ABC transporter signature motif; other site 760570003887 Walker B; other site 760570003888 D-loop; other site 760570003889 H-loop/switch region; other site 760570003890 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 760570003891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760570003892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760570003893 dimer interface [polypeptide binding]; other site 760570003894 phosphorylation site [posttranslational modification] 760570003895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570003896 ATP binding site [chemical binding]; other site 760570003897 Mg2+ binding site [ion binding]; other site 760570003898 G-X-G motif; other site 760570003899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760570003900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570003901 active site 760570003902 phosphorylation site [posttranslational modification] 760570003903 intermolecular recognition site; other site 760570003904 dimerization interface [polypeptide binding]; other site 760570003905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760570003906 DNA binding site [nucleotide binding] 760570003907 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 760570003908 beta-galactosidase; Region: BGL; TIGR03356 760570003909 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760570003910 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 760570003911 active site 760570003912 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 760570003913 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 760570003914 PYR/PP interface [polypeptide binding]; other site 760570003915 dimer interface [polypeptide binding]; other site 760570003916 tetramer interface [polypeptide binding]; other site 760570003917 TPP binding site [chemical binding]; other site 760570003918 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 760570003919 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 760570003920 TPP-binding site [chemical binding]; other site 760570003921 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 760570003922 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 760570003923 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760570003924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570003925 motif II; other site 760570003926 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 760570003927 Predicted transcriptional regulator [Transcription]; Region: COG3682 760570003928 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 760570003929 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 760570003930 active site 760570003931 catalytic triad [active] 760570003932 oxyanion hole [active] 760570003933 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 760570003934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570003935 active site 760570003936 motif I; other site 760570003937 motif II; other site 760570003938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570003939 HD domain; Region: HD_3; pfam13023 760570003940 Protein of unknown function (DUF554); Region: DUF554; pfam04474 760570003941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570003942 Walker A/P-loop; other site 760570003943 ATP binding site [chemical binding]; other site 760570003944 Q-loop/lid; other site 760570003945 ABC transporter signature motif; other site 760570003946 Walker B; other site 760570003947 D-loop; other site 760570003948 H-loop/switch region; other site 760570003949 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 760570003950 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 760570003951 putative active site [active] 760570003952 putative metal binding site [ion binding]; other site 760570003953 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 760570003954 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 760570003955 SelR domain; Region: SelR; pfam01641 760570003956 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 760570003957 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 760570003958 active site 760570003959 FMN binding site [chemical binding]; other site 760570003960 substrate binding site [chemical binding]; other site 760570003961 catalytic residues [active] 760570003962 homodimer interface [polypeptide binding]; other site 760570003963 glutamate dehydrogenase; Provisional; Region: PRK09414 760570003964 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 760570003965 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 760570003966 NAD(P) binding site [chemical binding]; other site 760570003967 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 760570003968 Mechanosensitive ion channel; Region: MS_channel; pfam00924 760570003969 serine/threonine transporter SstT; Provisional; Region: PRK13628 760570003970 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 760570003971 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 760570003972 amino acid carrier protein; Region: agcS; TIGR00835 760570003973 Peptidase family C69; Region: Peptidase_C69; pfam03577 760570003974 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 760570003975 MutS domain III; Region: MutS_III; pfam05192 760570003976 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 760570003977 Walker A/P-loop; other site 760570003978 ATP binding site [chemical binding]; other site 760570003979 Q-loop/lid; other site 760570003980 ABC transporter signature motif; other site 760570003981 Walker B; other site 760570003982 D-loop; other site 760570003983 H-loop/switch region; other site 760570003984 Smr domain; Region: Smr; pfam01713 760570003985 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 760570003986 Colicin V production protein; Region: Colicin_V; pfam02674 760570003987 ribonuclease HIII; Provisional; Region: PRK00996 760570003988 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 760570003989 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 760570003990 RNA/DNA hybrid binding site [nucleotide binding]; other site 760570003991 active site 760570003992 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 760570003993 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 760570003994 Catalytic site [active] 760570003995 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 760570003996 AAA domain; Region: AAA_30; pfam13604 760570003997 Family description; Region: UvrD_C_2; pfam13538 760570003998 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 760570003999 active site 760570004000 DNA polymerase IV; Validated; Region: PRK02406 760570004001 DNA binding site [nucleotide binding] 760570004002 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 760570004003 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 760570004004 Uncharacterized conserved protein [Function unknown]; Region: COG2966 760570004005 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 760570004006 Uncharacterized conserved protein [Function unknown]; Region: COG3610 760570004007 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 760570004008 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 760570004009 dimer interface [polypeptide binding]; other site 760570004010 active site 760570004011 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 760570004012 homodimer interface [polypeptide binding]; other site 760570004013 catalytic residues [active] 760570004014 NAD binding site [chemical binding]; other site 760570004015 substrate binding pocket [chemical binding]; other site 760570004016 flexible flap; other site 760570004017 Transposase IS200 like; Region: Y1_Tnp; pfam01797 760570004018 Protease prsW family; Region: PrsW-protease; pfam13367 760570004019 Peptidase family C69; Region: Peptidase_C69; cl17793 760570004020 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 760570004021 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 760570004022 homotetramer interface [polypeptide binding]; other site 760570004023 FMN binding site [chemical binding]; other site 760570004024 homodimer contacts [polypeptide binding]; other site 760570004025 putative active site [active] 760570004026 putative substrate binding site [chemical binding]; other site 760570004027 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 760570004028 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 760570004029 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 760570004030 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 760570004031 diphosphomevalonate decarboxylase; Region: PLN02407 760570004032 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 760570004033 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 760570004034 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 760570004035 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760570004036 Beta-lactamase; Region: Beta-lactamase; pfam00144 760570004037 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 760570004038 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 760570004039 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 760570004040 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 760570004041 HTH domain; Region: HTH_11; cl17392 760570004042 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 760570004043 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 760570004044 active site 760570004045 catalytic site [active] 760570004046 substrate binding site [chemical binding]; other site 760570004047 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570004048 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 760570004049 Walker A/P-loop; other site 760570004050 ATP binding site [chemical binding]; other site 760570004051 Q-loop/lid; other site 760570004052 ABC transporter signature motif; other site 760570004053 Walker B; other site 760570004054 D-loop; other site 760570004055 H-loop/switch region; other site 760570004056 hypothetical protein; Validated; Region: PRK00153 760570004057 LrgB-like family; Region: LrgB; pfam04172 760570004058 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 760570004059 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 760570004060 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 760570004061 amphipathic channel; other site 760570004062 Asn-Pro-Ala signature motifs; other site 760570004063 Predicted membrane protein [Function unknown]; Region: COG4392 760570004064 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 760570004065 Protein of unknown function (DUF443); Region: DUF443; cl04467 760570004066 Protein of unknown function (DUF443); Region: DUF443; cl04467 760570004067 UGMP family protein; Validated; Region: PRK09604 760570004068 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 760570004069 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 760570004070 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 760570004071 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760570004072 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 760570004073 Glycoprotease family; Region: Peptidase_M22; pfam00814 760570004074 hypothetical protein; Provisional; Region: PRK13667 760570004075 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 760570004076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 760570004077 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 760570004078 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 760570004079 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 760570004080 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 760570004081 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 760570004082 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 760570004083 DNA binding residues [nucleotide binding] 760570004084 putative dimer interface [polypeptide binding]; other site 760570004085 Predicted membrane protein [Function unknown]; Region: COG4129 760570004086 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 760570004087 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 760570004088 Phosphoglycerate kinase; Region: PGK; pfam00162 760570004089 substrate binding site [chemical binding]; other site 760570004090 hinge regions; other site 760570004091 ADP binding site [chemical binding]; other site 760570004092 catalytic site [active] 760570004093 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 760570004094 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 760570004095 Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644 760570004096 active site 760570004097 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 760570004098 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 760570004099 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 760570004100 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 760570004101 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 760570004102 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 760570004103 elongation factor G; Reviewed; Region: PRK00007 760570004104 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 760570004105 G1 box; other site 760570004106 putative GEF interaction site [polypeptide binding]; other site 760570004107 GTP/Mg2+ binding site [chemical binding]; other site 760570004108 Switch I region; other site 760570004109 G2 box; other site 760570004110 G3 box; other site 760570004111 Switch II region; other site 760570004112 G4 box; other site 760570004113 G5 box; other site 760570004114 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 760570004115 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 760570004116 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 760570004117 30S ribosomal protein S7; Validated; Region: PRK05302 760570004118 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 760570004119 S17 interaction site [polypeptide binding]; other site 760570004120 S8 interaction site; other site 760570004121 16S rRNA interaction site [nucleotide binding]; other site 760570004122 streptomycin interaction site [chemical binding]; other site 760570004123 23S rRNA interaction site [nucleotide binding]; other site 760570004124 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 760570004125 pur operon repressor; Provisional; Region: PRK09213 760570004126 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 760570004127 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570004128 active site 760570004129 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 760570004130 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 760570004131 generic binding surface II; other site 760570004132 generic binding surface I; other site 760570004133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760570004134 Zn2+ binding site [ion binding]; other site 760570004135 Mg2+ binding site [ion binding]; other site 760570004136 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 760570004137 RmuC family; Region: RmuC; pfam02646 760570004138 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 760570004139 Thiamine pyrophosphokinase; Region: TPK; cd07995 760570004140 active site 760570004141 dimerization interface [polypeptide binding]; other site 760570004142 thiamine binding site [chemical binding]; other site 760570004143 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 760570004144 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 760570004145 substrate binding site [chemical binding]; other site 760570004146 hexamer interface [polypeptide binding]; other site 760570004147 metal binding site [ion binding]; metal-binding site 760570004148 GTPase RsgA; Reviewed; Region: PRK00098 760570004149 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 760570004150 RNA binding site [nucleotide binding]; other site 760570004151 homodimer interface [polypeptide binding]; other site 760570004152 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 760570004153 GTPase/Zn-binding domain interface [polypeptide binding]; other site 760570004154 GTP/Mg2+ binding site [chemical binding]; other site 760570004155 G4 box; other site 760570004156 G1 box; other site 760570004157 Switch I region; other site 760570004158 G2 box; other site 760570004159 G3 box; other site 760570004160 Switch II region; other site 760570004161 CAAX protease self-immunity; Region: Abi; pfam02517 760570004162 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 760570004163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570004164 S-adenosylmethionine binding site [chemical binding]; other site 760570004165 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 760570004166 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 760570004167 putative active site [active] 760570004168 putative metal binding site [ion binding]; other site 760570004169 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 760570004170 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 760570004171 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 760570004172 active site 760570004173 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 760570004174 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 760570004175 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 760570004176 G-X-X-G motif; other site 760570004177 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 760570004178 RxxxH motif; other site 760570004179 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 760570004180 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 760570004181 ribonuclease P; Reviewed; Region: rnpA; PRK00499 760570004182 CAAX protease self-immunity; Region: Abi; pfam02517 760570004183 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 760570004184 gating phenylalanine in ion channel; other site 760570004185 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 760570004186 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 760570004187 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 760570004188 Rib/alpha-like repeat; Region: Rib; cl07159 760570004189 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 760570004190 serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224 760570004191 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 760570004192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760570004193 ATP binding site [chemical binding]; other site 760570004194 putative Mg++ binding site [ion binding]; other site 760570004195 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 760570004196 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 760570004197 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 760570004198 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 760570004199 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 760570004200 SecY translocase; Region: SecY; pfam00344 760570004201 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 760570004202 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 760570004203 Ligand binding site; other site 760570004204 metal-binding site 760570004205 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 760570004206 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 760570004207 Ligand binding site; other site 760570004208 metal-binding site 760570004209 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 760570004210 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 760570004211 active site 760570004212 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 760570004213 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760570004214 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 760570004215 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 760570004216 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760570004217 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 760570004218 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 760570004219 Ligand binding site; other site 760570004220 metal-binding site 760570004221 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 760570004222 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 760570004223 Ligand binding site; other site 760570004224 metal-binding site 760570004225 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 760570004226 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 760570004227 trimer interface [polypeptide binding]; other site 760570004228 active site 760570004229 substrate binding site [chemical binding]; other site 760570004230 CoA binding site [chemical binding]; other site 760570004231 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760570004232 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 760570004233 active site 760570004234 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 760570004235 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 760570004236 Ligand binding site; other site 760570004237 metal-binding site 760570004238 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 760570004239 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 760570004240 trimer interface [polypeptide binding]; other site 760570004241 active site 760570004242 substrate binding site [chemical binding]; other site 760570004243 CoA binding site [chemical binding]; other site 760570004244 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 760570004245 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 760570004246 active site 760570004247 HIGH motif; other site 760570004248 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 760570004249 active site 760570004250 KMSKS motif; other site 760570004251 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 760570004252 Predicted esterase [General function prediction only]; Region: COG0627 760570004253 S-formylglutathione hydrolase; Region: PLN02442 760570004254 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 760570004255 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 760570004256 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 760570004257 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 760570004258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570004259 Walker A/P-loop; other site 760570004260 ATP binding site [chemical binding]; other site 760570004261 Q-loop/lid; other site 760570004262 ABC transporter signature motif; other site 760570004263 Walker B; other site 760570004264 D-loop; other site 760570004265 H-loop/switch region; other site 760570004266 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760570004267 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 760570004268 TM-ABC transporter signature motif; other site 760570004269 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 760570004270 T surface-antigen of pili; Region: FctA; cl16948 760570004271 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 760570004272 T surface-antigen of pili; Region: FctA; cl16948 760570004273 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 760570004274 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 760570004275 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 760570004276 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 760570004277 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 760570004278 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 760570004279 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 760570004280 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 760570004281 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 760570004282 Unresolvable tandem repeat 760570004283 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 760570004284 active site clefts [active] 760570004285 zinc binding site [ion binding]; other site 760570004286 dimer interface [polypeptide binding]; other site 760570004287 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 760570004288 Walker A motif; other site 760570004289 ATP binding site [chemical binding]; other site 760570004290 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760570004291 Walker B motif; other site 760570004292 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 760570004293 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760570004294 catalytic core [active] 760570004295 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 760570004296 trimer interface [polypeptide binding]; other site 760570004297 active site 760570004298 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570004299 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 760570004300 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 760570004301 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 760570004302 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570004303 Unresolvable tandem repeat 760570004304 legume lectins; Region: lectin_L-type; cd01951 760570004305 homotetramer interaction site [polypeptide binding]; other site 760570004306 carbohydrate binding site [chemical binding]; other site 760570004307 metal binding site [ion binding]; metal-binding site 760570004308 potential frameshift: common BLAST hit: gi|254556548|ref|YP_003062965.1| cell surface protein precursor 760570004309 MucBP domain; Region: MucBP; pfam06458 760570004310 MucBP domain; Region: MucBP; pfam06458 760570004311 MucBP domain; Region: MucBP; pfam06458 760570004312 MucBP domain; Region: MucBP; pfam06458 760570004313 MucBP domain; Region: MucBP; pfam06458 760570004314 MucBP domain; Region: MucBP; pfam06458 760570004315 Unresolvable tandem repeat 760570004316 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 760570004317 MARCKS family; Region: MARCKS; pfam02063 760570004318 MucBP domain; Region: MucBP; pfam06458 760570004319 MucBP domain; Region: MucBP; pfam06458 760570004320 MucBP domain; Region: MucBP; pfam06458 760570004321 MucBP domain; Region: MucBP; pfam06458 760570004322 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 760570004323 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 760570004324 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 760570004325 catalytic triad [active] 760570004326 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 760570004327 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 760570004328 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 760570004329 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 760570004330 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 760570004331 active site 760570004332 tetramer interface; other site 760570004333 Peptidase family C69; Region: Peptidase_C69; pfam03577 760570004334 Rhomboid family; Region: Rhomboid; pfam01694 760570004335 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 760570004336 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 760570004337 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 760570004338 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 760570004339 metal binding site [ion binding]; metal-binding site 760570004340 putative dimer interface [polypeptide binding]; other site 760570004341 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 760570004342 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 760570004343 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 760570004344 trimer interface [polypeptide binding]; other site 760570004345 active site 760570004346 substrate binding site [chemical binding]; other site 760570004347 CoA binding site [chemical binding]; other site 760570004348 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570004349 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 760570004350 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 760570004351 active site 760570004352 dimer interface [polypeptide binding]; other site 760570004353 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 760570004354 dimer interface [polypeptide binding]; other site 760570004355 active site 760570004356 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 760570004357 nucleoside/Zn binding site; other site 760570004358 dimer interface [polypeptide binding]; other site 760570004359 catalytic motif [active] 760570004360 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760570004361 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570004362 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 760570004363 Walker A/P-loop; other site 760570004364 ATP binding site [chemical binding]; other site 760570004365 Q-loop/lid; other site 760570004366 ABC transporter signature motif; other site 760570004367 Walker B; other site 760570004368 D-loop; other site 760570004369 H-loop/switch region; other site 760570004370 Radical SAM superfamily; Region: Radical_SAM; pfam04055 760570004371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760570004372 FeS/SAM binding site; other site 760570004373 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 760570004374 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 760570004375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570004376 motif II; other site 760570004377 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 760570004378 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 760570004379 GDP-binding site [chemical binding]; other site 760570004380 ACT binding site; other site 760570004381 IMP binding site; other site 760570004382 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 760570004383 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 760570004384 dimerization interface [polypeptide binding]; other site 760570004385 domain crossover interface; other site 760570004386 redox-dependent activation switch; other site 760570004387 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 760570004388 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 760570004389 FMN binding site [chemical binding]; other site 760570004390 active site 760570004391 catalytic residues [active] 760570004392 substrate binding site [chemical binding]; other site 760570004393 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 760570004394 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 760570004395 nudix motif; other site 760570004396 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 760570004397 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 760570004398 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760570004399 active site 760570004400 nucleotide binding site [chemical binding]; other site 760570004401 HIGH motif; other site 760570004402 KMSKS motif; other site 760570004403 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 760570004404 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 760570004405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570004406 Walker A motif; other site 760570004407 ATP binding site [chemical binding]; other site 760570004408 Walker B motif; other site 760570004409 arginine finger; other site 760570004410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570004411 Walker A motif; other site 760570004412 ATP binding site [chemical binding]; other site 760570004413 Walker B motif; other site 760570004414 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 760570004415 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 760570004416 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 760570004417 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 760570004418 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 760570004419 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 760570004420 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 760570004421 Calx-beta domain; Region: Calx-beta; cl02522 760570004422 G5 domain; Region: G5; pfam07501 760570004423 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 760570004424 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760570004425 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 760570004426 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760570004427 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760570004428 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 760570004429 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 760570004430 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 760570004431 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 760570004432 G5 domain; Region: G5; pfam07501 760570004433 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570004434 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 760570004435 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 760570004436 dimerization interface [polypeptide binding]; other site 760570004437 DPS ferroxidase diiron center [ion binding]; other site 760570004438 ion pore; other site 760570004439 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 760570004440 elongation factor Ts; Provisional; Region: tsf; PRK09377 760570004441 UBA/TS-N domain; Region: UBA; pfam00627 760570004442 Elongation factor TS; Region: EF_TS; pfam00889 760570004443 Elongation factor TS; Region: EF_TS; pfam00889 760570004444 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 760570004445 rRNA interaction site [nucleotide binding]; other site 760570004446 S8 interaction site; other site 760570004447 putative laminin-1 binding site; other site 760570004448 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 760570004449 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 760570004450 putative homodimer interface [polypeptide binding]; other site 760570004451 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 760570004452 heterodimer interface [polypeptide binding]; other site 760570004453 homodimer interface [polypeptide binding]; other site 760570004454 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 760570004455 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 760570004456 Predicted metalloprotease [General function prediction only]; Region: COG2321 760570004457 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 760570004458 Transglycosylase; Region: Transgly; pfam00912 760570004459 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 760570004460 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 760570004461 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760570004462 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760570004463 active site 760570004464 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 760570004465 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 760570004466 active site 760570004467 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 760570004468 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 760570004469 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 760570004470 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 760570004471 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 760570004472 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 760570004473 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 760570004474 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 760570004475 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 760570004476 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 760570004477 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 760570004478 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 760570004479 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 760570004480 active site 760570004481 homodimer interface [polypeptide binding]; other site 760570004482 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760570004483 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 760570004484 Probable Catalytic site; other site 760570004485 metal-binding site 760570004486 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 760570004487 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760570004488 putative homodimer interface [polypeptide binding]; other site 760570004489 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 760570004490 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760570004491 active site 760570004492 LicD family; Region: LicD; pfam04991 760570004493 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 760570004494 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 760570004495 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 760570004496 Bacterial sugar transferase; Region: Bac_transf; pfam02397 760570004497 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 760570004498 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760570004499 Chain length determinant protein; Region: Wzz; cl15801 760570004500 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 760570004501 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 760570004502 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760570004503 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 760570004504 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 760570004505 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760570004506 FeS/SAM binding site; other site 760570004507 Predicted acetyltransferase [General function prediction only]; Region: COG3981 760570004508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760570004509 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 760570004510 ATP cone domain; Region: ATP-cone; pfam03477 760570004511 Class III ribonucleotide reductase; Region: RNR_III; cd01675 760570004512 effector binding site; other site 760570004513 active site 760570004514 Zn binding site [ion binding]; other site 760570004515 glycine loop; other site 760570004516 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 760570004517 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 760570004518 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 760570004519 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 760570004520 putative active site [active] 760570004521 catalytic site [active] 760570004522 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 760570004523 putative active site [active] 760570004524 catalytic site [active] 760570004525 Bacterial lipoprotein; Region: DUF3642; pfam12182 760570004526 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 760570004527 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760570004528 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760570004529 hypothetical protein; Provisional; Region: PRK13678 760570004530 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 760570004531 hypothetical protein; Provisional; Region: PRK05473 760570004532 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 760570004533 ArsC family; Region: ArsC; pfam03960 760570004534 putative catalytic residues [active] 760570004535 thiol/disulfide switch; other site 760570004536 recombinase A; Provisional; Region: recA; PRK09354 760570004537 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 760570004538 hexamer interface [polypeptide binding]; other site 760570004539 Walker A motif; other site 760570004540 ATP binding site [chemical binding]; other site 760570004541 Walker B motif; other site 760570004542 competence damage-inducible protein A; Provisional; Region: PRK00549 760570004543 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 760570004544 putative MPT binding site; other site 760570004545 Competence-damaged protein; Region: CinA; pfam02464 760570004546 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 760570004547 putative dimer interface [polypeptide binding]; other site 760570004548 catalytic triad [active] 760570004549 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 760570004550 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 760570004551 RuvA N terminal domain; Region: RuvA_N; pfam01330 760570004552 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 760570004553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570004554 ATP binding site [chemical binding]; other site 760570004555 Mg2+ binding site [ion binding]; other site 760570004556 G-X-G motif; other site 760570004557 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 760570004558 ATP binding site [chemical binding]; other site 760570004559 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 760570004560 LytTr DNA-binding domain; Region: LytTR; smart00850 760570004561 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 760570004562 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 760570004563 MutS domain I; Region: MutS_I; pfam01624 760570004564 MutS domain II; Region: MutS_II; pfam05188 760570004565 MutS domain III; Region: MutS_III; pfam05192 760570004566 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 760570004567 Walker A/P-loop; other site 760570004568 ATP binding site [chemical binding]; other site 760570004569 Q-loop/lid; other site 760570004570 ABC transporter signature motif; other site 760570004571 Walker B; other site 760570004572 D-loop; other site 760570004573 H-loop/switch region; other site 760570004574 Arginine repressor [Transcription]; Region: ArgR; COG1438 760570004575 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 760570004576 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 760570004577 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 760570004578 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 760570004579 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 760570004580 active site 760570004581 HIGH motif; other site 760570004582 KMSK motif region; other site 760570004583 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 760570004584 tRNA binding surface [nucleotide binding]; other site 760570004585 anticodon binding site; other site 760570004586 flavoprotein NrdI; Provisional; Region: PRK02551 760570004587 Glucan-binding protein C; Region: GbpC; pfam08363 760570004588 Glucan-binding protein C; Region: GbpC; pfam08363 760570004589 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570004590 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760570004591 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 760570004592 4-alpha-glucanotransferase; Provisional; Region: PRK14508 760570004593 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 760570004594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760570004595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570004596 dimer interface [polypeptide binding]; other site 760570004597 conserved gate region; other site 760570004598 putative PBP binding loops; other site 760570004599 ABC-ATPase subunit interface; other site 760570004600 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760570004601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570004602 dimer interface [polypeptide binding]; other site 760570004603 conserved gate region; other site 760570004604 putative PBP binding loops; other site 760570004605 ABC-ATPase subunit interface; other site 760570004606 Predicted integral membrane protein [Function unknown]; Region: COG5521 760570004607 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760570004608 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760570004609 DNA binding site [nucleotide binding] 760570004610 domain linker motif; other site 760570004611 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760570004612 pullulanase, type I; Region: pulA_typeI; TIGR02104 760570004613 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 760570004614 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 760570004615 Ca binding site [ion binding]; other site 760570004616 active site 760570004617 catalytic site [active] 760570004618 Uncharacterized conserved protein [Function unknown]; Region: COG1284 760570004619 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 760570004620 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 760570004621 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 760570004622 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 760570004623 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 760570004624 dimer interface [polypeptide binding]; other site 760570004625 anticodon binding site; other site 760570004626 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 760570004627 homodimer interface [polypeptide binding]; other site 760570004628 motif 1; other site 760570004629 active site 760570004630 motif 2; other site 760570004631 GAD domain; Region: GAD; pfam02938 760570004632 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 760570004633 motif 3; other site 760570004634 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 760570004635 DltD N-terminal region; Region: DltD_N; pfam04915 760570004636 DltD central region; Region: DltD_M; pfam04918 760570004637 DltD C-terminal region; Region: DltD_C; pfam04914 760570004638 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 760570004639 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 760570004640 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 760570004641 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 760570004642 acyl-activating enzyme (AAE) consensus motif; other site 760570004643 AMP binding site [chemical binding]; other site 760570004644 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 760570004645 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 760570004646 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760570004647 Active site serine [active] 760570004648 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 760570004649 putative metal binding residues [ion binding]; other site 760570004650 signature motif; other site 760570004651 dimer interface [polypeptide binding]; other site 760570004652 active site 760570004653 polyP binding site; other site 760570004654 substrate binding site [chemical binding]; other site 760570004655 acceptor-phosphate pocket; other site 760570004656 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 760570004657 Predicted membrane protein [Function unknown]; Region: COG1511 760570004658 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 760570004659 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 760570004660 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 760570004661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760570004662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760570004663 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 760570004664 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 760570004665 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760570004666 RNA binding surface [nucleotide binding]; other site 760570004667 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 760570004668 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 760570004669 Walker A/P-loop; other site 760570004670 ATP binding site [chemical binding]; other site 760570004671 Q-loop/lid; other site 760570004672 ABC transporter signature motif; other site 760570004673 Walker B; other site 760570004674 D-loop; other site 760570004675 H-loop/switch region; other site 760570004676 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 760570004677 NMT1/THI5 like; Region: NMT1; pfam09084 760570004678 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 760570004679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570004680 dimer interface [polypeptide binding]; other site 760570004681 conserved gate region; other site 760570004682 putative PBP binding loops; other site 760570004683 ABC-ATPase subunit interface; other site 760570004684 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 760570004685 replicative DNA helicase; Provisional; Region: PRK05748 760570004686 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 760570004687 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 760570004688 Walker A motif; other site 760570004689 ATP binding site [chemical binding]; other site 760570004690 Walker B motif; other site 760570004691 DNA binding loops [nucleotide binding] 760570004692 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 760570004693 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 760570004694 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 760570004695 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 760570004696 DHH family; Region: DHH; pfam01368 760570004697 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 760570004698 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 760570004699 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 760570004700 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 760570004701 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 760570004702 nudix motif; other site 760570004703 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 760570004704 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 760570004705 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 760570004706 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760570004707 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 760570004708 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 760570004709 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 760570004710 putative L-serine binding site [chemical binding]; other site 760570004711 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 760570004712 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 760570004713 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 760570004714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570004715 motif II; other site 760570004716 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760570004717 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 760570004718 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 760570004719 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 760570004720 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760570004721 Walker A/P-loop; other site 760570004722 ATP binding site [chemical binding]; other site 760570004723 Q-loop/lid; other site 760570004724 ABC transporter signature motif; other site 760570004725 Walker B; other site 760570004726 D-loop; other site 760570004727 H-loop/switch region; other site 760570004728 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 760570004729 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760570004730 Walker A/P-loop; other site 760570004731 ATP binding site [chemical binding]; other site 760570004732 Q-loop/lid; other site 760570004733 ABC transporter signature motif; other site 760570004734 Walker B; other site 760570004735 D-loop; other site 760570004736 H-loop/switch region; other site 760570004737 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 760570004738 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 760570004739 Helix-turn-helix domain; Region: HTH_25; pfam13413 760570004740 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760570004741 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760570004742 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760570004743 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760570004744 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760570004745 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760570004746 RNA binding surface [nucleotide binding]; other site 760570004747 recombination protein F; Reviewed; Region: recF; PRK00064 760570004748 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 760570004749 Walker A/P-loop; other site 760570004750 ATP binding site [chemical binding]; other site 760570004751 Q-loop/lid; other site 760570004752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570004753 ABC transporter signature motif; other site 760570004754 Walker B; other site 760570004755 D-loop; other site 760570004756 H-loop/switch region; other site 760570004757 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 760570004758 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 760570004759 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 760570004760 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 760570004761 active site 760570004762 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 760570004763 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 760570004764 active site 760570004765 HIGH motif; other site 760570004766 dimer interface [polypeptide binding]; other site 760570004767 KMSKS motif; other site 760570004768 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 760570004769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570004770 Walker A/P-loop; other site 760570004771 ATP binding site [chemical binding]; other site 760570004772 Q-loop/lid; other site 760570004773 ABC transporter signature motif; other site 760570004774 Walker B; other site 760570004775 D-loop; other site 760570004776 H-loop/switch region; other site 760570004777 ABC transporter; Region: ABC_tran_2; pfam12848 760570004778 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760570004779 Predicted membrane protein [Function unknown]; Region: COG4485 760570004780 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760570004781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570004782 active site 760570004783 phosphorylation site [posttranslational modification] 760570004784 intermolecular recognition site; other site 760570004785 dimerization interface [polypeptide binding]; other site 760570004786 LytTr DNA-binding domain; Region: LytTR; pfam04397 760570004787 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760570004788 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 760570004789 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 760570004790 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 760570004791 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760570004792 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760570004793 protein binding site [polypeptide binding]; other site 760570004794 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 760570004795 ParB-like nuclease domain; Region: ParBc; pfam02195 760570004796 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 760570004797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570004798 Walker A motif; other site 760570004799 ATP binding site [chemical binding]; other site 760570004800 Walker B motif; other site 760570004801 arginine finger; other site 760570004802 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 760570004803 DnaA box-binding interface [nucleotide binding]; other site 760570004804 DNA polymerase III subunit beta; Validated; Region: PRK05643 760570004805 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 760570004806 putative DNA binding surface [nucleotide binding]; other site 760570004807 dimer interface [polypeptide binding]; other site 760570004808 beta-clamp/clamp loader binding surface; other site 760570004809 beta-clamp/translesion DNA polymerase binding surface; other site 760570004810 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 760570004811 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 760570004812 GTP-binding protein YchF; Reviewed; Region: PRK09601 760570004813 YchF GTPase; Region: YchF; cd01900 760570004814 G1 box; other site 760570004815 GTP/Mg2+ binding site [chemical binding]; other site 760570004816 Switch I region; other site 760570004817 G2 box; other site 760570004818 Switch II region; other site 760570004819 G3 box; other site 760570004820 G4 box; other site 760570004821 G5 box; other site 760570004822 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 760570004823 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 760570004824 putative active site [active] 760570004825 catalytic residue [active] 760570004826 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 760570004827 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 760570004828 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760570004829 ATP binding site [chemical binding]; other site 760570004830 putative Mg++ binding site [ion binding]; other site 760570004831 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570004832 nucleotide binding region [chemical binding]; other site 760570004833 ATP-binding site [chemical binding]; other site 760570004834 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 760570004835 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760570004836 RNA binding surface [nucleotide binding]; other site 760570004837 Septum formation initiator; Region: DivIC; cl17659 760570004838 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 760570004839 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 760570004840 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 760570004841 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 760570004842 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 760570004843 Ligand Binding Site [chemical binding]; other site 760570004844 TilS substrate C-terminal domain; Region: TilS_C; smart00977 760570004845 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 760570004846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570004847 active site 760570004848 FtsH Extracellular; Region: FtsH_ext; pfam06480 760570004849 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 760570004850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570004851 Walker A motif; other site 760570004852 ATP binding site [chemical binding]; other site 760570004853 Walker B motif; other site 760570004854 arginine finger; other site 760570004855 Peptidase family M41; Region: Peptidase_M41; pfam01434 760570004856 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 760570004857 Helix-turn-helix domain; Region: HTH_38; pfam13936 760570004858 Integrase core domain; Region: rve; pfam00665 760570004859 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 760570004860 rod shape-determining protein MreC; Region: MreC; pfam04085 760570004861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 760570004862 Septum formation initiator; Region: DivIC; cl17659 760570004863 Surface antigen [General function prediction only]; Region: COG3942 760570004864 CHAP domain; Region: CHAP; pfam05257 760570004865 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 760570004866 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 760570004867 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570004868 active site 760570004869 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 760570004870 active site 760570004871 catalytic site [active] 760570004872 aromatic amino acid aminotransferase; Validated; Region: PRK07309 760570004873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760570004874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570004875 homodimer interface [polypeptide binding]; other site 760570004876 catalytic residue [active] 760570004877 Recombination protein O N terminal; Region: RecO_N; pfam11967 760570004878 DNA repair protein RecO; Region: reco; TIGR00613 760570004879 Recombination protein O C terminal; Region: RecO_C; pfam02565 760570004880 putative phosphate acyltransferase; Provisional; Region: PRK05331 760570004881 Phosphopantetheine attachment site; Region: PP-binding; cl09936 760570004882 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 760570004883 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 760570004884 ATP binding site [chemical binding]; other site 760570004885 active site 760570004886 substrate binding site [chemical binding]; other site 760570004887 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 760570004888 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 760570004889 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 760570004890 dimerization interface [polypeptide binding]; other site 760570004891 ATP binding site [chemical binding]; other site 760570004892 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 760570004893 dimerization interface [polypeptide binding]; other site 760570004894 ATP binding site [chemical binding]; other site 760570004895 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 760570004896 putative active site [active] 760570004897 catalytic triad [active] 760570004898 amidophosphoribosyltransferase; Provisional; Region: PRK07272 760570004899 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 760570004900 active site 760570004901 tetramer interface [polypeptide binding]; other site 760570004902 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760570004903 active site 760570004904 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 760570004905 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 760570004906 dimerization interface [polypeptide binding]; other site 760570004907 putative ATP binding site [chemical binding]; other site 760570004908 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 760570004909 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 760570004910 active site 760570004911 substrate binding site [chemical binding]; other site 760570004912 cosubstrate binding site; other site 760570004913 catalytic site [active] 760570004914 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 760570004915 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 760570004916 purine monophosphate binding site [chemical binding]; other site 760570004917 dimer interface [polypeptide binding]; other site 760570004918 putative catalytic residues [active] 760570004919 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 760570004920 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 760570004921 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 760570004922 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 760570004923 CHAP domain; Region: CHAP; pfam05257 760570004924 Surface antigen [General function prediction only]; Region: COG3942 760570004925 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 760570004926 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 760570004927 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 760570004928 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 760570004929 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 760570004930 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 760570004931 ATP-grasp domain; Region: ATP-grasp; pfam02222 760570004932 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 760570004933 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 760570004934 adenylosuccinate lyase; Provisional; Region: PRK07492 760570004935 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 760570004936 tetramer interface [polypeptide binding]; other site 760570004937 active site 760570004938 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 760570004939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760570004940 DNA-binding site [nucleotide binding]; DNA binding site 760570004941 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 760570004942 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 760570004943 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 760570004944 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 760570004945 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 760570004946 active site 760570004947 phosphorylation site [posttranslational modification] 760570004948 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 760570004949 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 760570004950 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 760570004951 active pocket/dimerization site; other site 760570004952 active site 760570004953 phosphorylation site [posttranslational modification] 760570004954 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 760570004955 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 760570004956 dimer interface [polypeptide binding]; other site 760570004957 active site 760570004958 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 760570004959 putative active site [active] 760570004960 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 760570004961 active site 760570004962 catalytic residues [active] 760570004963 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 760570004964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570004965 Walker A motif; other site 760570004966 ATP binding site [chemical binding]; other site 760570004967 Walker B motif; other site 760570004968 arginine finger; other site 760570004969 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 760570004970 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 760570004971 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 760570004972 Low molecular weight phosphatase family; Region: LMWPc; cd00115 760570004973 active site 760570004974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 760570004975 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 760570004976 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 760570004977 active site 760570004978 catalytic triad [active] 760570004979 oxyanion hole [active] 760570004980 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 760570004981 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 760570004982 putative catalytic cysteine [active] 760570004983 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 760570004984 putative active site [active] 760570004985 metal binding site [ion binding]; metal-binding site 760570004986 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK06278 760570004987 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 760570004988 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 760570004989 catalytic Zn binding site [ion binding]; other site 760570004990 structural Zn binding site [ion binding]; other site 760570004991 NAD(P) binding site [chemical binding]; other site 760570004992 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 760570004993 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 760570004994 putative active site cavity [active] 760570004995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760570004996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760570004997 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 760570004998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 760570004999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570005000 dimer interface [polypeptide binding]; other site 760570005001 ABC-ATPase subunit interface; other site 760570005002 putative PBP binding loops; other site 760570005003 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760570005004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570005005 dimer interface [polypeptide binding]; other site 760570005006 conserved gate region; other site 760570005007 putative PBP binding loops; other site 760570005008 ABC-ATPase subunit interface; other site 760570005009 Domain of unknown function (DUF386); Region: DUF386; pfam04074 760570005010 Protein of unknown function, DUF624; Region: DUF624; pfam04854 760570005011 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 760570005012 Class I aldolases; Region: Aldolase_Class_I; cl17187 760570005013 catalytic residue [active] 760570005014 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760570005015 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760570005016 nucleotide binding site [chemical binding]; other site 760570005017 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 760570005018 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 760570005019 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 760570005020 putative active site [active] 760570005021 V-type ATP synthase subunit I; Validated; Region: PRK05771 760570005022 V-type ATP synthase subunit K; Validated; Region: PRK08344 760570005023 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 760570005024 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 760570005025 phosphodiesterase; Provisional; Region: PRK12704 760570005026 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 760570005027 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 760570005028 V-type ATP synthase subunit F; Provisional; Region: PRK01395 760570005029 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 760570005030 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760570005031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 760570005032 V-type ATP synthase subunit A; Provisional; Region: PRK04192 760570005033 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 760570005034 Walker A motif/ATP binding site; other site 760570005035 Walker B motif; other site 760570005036 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 760570005037 V-type ATP synthase subunit B; Provisional; Region: PRK04196 760570005038 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 760570005039 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 760570005040 Walker A motif homologous position; other site 760570005041 Walker B motif; other site 760570005042 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 760570005043 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 760570005044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760570005045 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 760570005046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570005047 putative substrate translocation pore; other site 760570005048 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760570005049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570005050 non-specific DNA binding site [nucleotide binding]; other site 760570005051 salt bridge; other site 760570005052 sequence-specific DNA binding site [nucleotide binding]; other site 760570005053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760570005054 dimerization interface [polypeptide binding]; other site 760570005055 putative DNA binding site [nucleotide binding]; other site 760570005056 putative Zn2+ binding site [ion binding]; other site 760570005057 Predicted integral membrane protein [Function unknown]; Region: COG5658 760570005058 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 760570005059 SdpI/YhfL protein family; Region: SdpI; pfam13630 760570005060 Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331 760570005061 Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331 760570005062 Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331 760570005063 Rib/alpha-like repeat; Region: Rib; pfam08428 760570005064 Rib/alpha-like repeat; Region: Rib; cl07159 760570005065 Rib/alpha-like repeat; Region: Rib; pfam08428 760570005066 Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331 760570005067 Rib/alpha-like repeat; Region: Rib; pfam08428 760570005068 Rib/alpha-like repeat; Region: Rib; pfam08428 760570005069 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 760570005070 Unresolvable tandem repeat 760570005071 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 760570005072 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 760570005073 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 760570005074 6-phosphogluconate dehydratase; Region: edd; TIGR01196 760570005075 uracil transporter; Provisional; Region: PRK10720 760570005076 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 760570005077 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 760570005078 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 760570005079 dimer interface [polypeptide binding]; other site 760570005080 motif 1; other site 760570005081 active site 760570005082 motif 2; other site 760570005083 motif 3; other site 760570005084 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 760570005085 anticodon binding site; other site 760570005086 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 760570005087 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 760570005088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570005089 catalytic residue [active] 760570005090 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 760570005091 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 760570005092 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 760570005093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570005094 motif II; other site 760570005095 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760570005096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760570005097 putative DNA binding site [nucleotide binding]; other site 760570005098 putative Zn2+ binding site [ion binding]; other site 760570005099 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 760570005100 T-box leader; HMPREF0833_nc10020 760570005101 anthranilate synthase component I; Provisional; Region: PRK13570 760570005102 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 760570005103 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 760570005104 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 760570005105 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 760570005106 glutamine binding [chemical binding]; other site 760570005107 catalytic triad [active] 760570005108 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 760570005109 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 760570005110 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 760570005111 active site 760570005112 ribulose/triose binding site [chemical binding]; other site 760570005113 phosphate binding site [ion binding]; other site 760570005114 substrate (anthranilate) binding pocket [chemical binding]; other site 760570005115 product (indole) binding pocket [chemical binding]; other site 760570005116 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 760570005117 active site 760570005118 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 760570005119 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 760570005120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570005121 catalytic residue [active] 760570005122 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 760570005123 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 760570005124 substrate binding site [chemical binding]; other site 760570005125 active site 760570005126 catalytic residues [active] 760570005127 heterodimer interface [polypeptide binding]; other site 760570005128 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 760570005129 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 760570005130 DNA polymerase I; Provisional; Region: PRK05755 760570005131 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 760570005132 active site 760570005133 metal binding site 1 [ion binding]; metal-binding site 760570005134 putative 5' ssDNA interaction site; other site 760570005135 metal binding site 3; metal-binding site 760570005136 metal binding site 2 [ion binding]; metal-binding site 760570005137 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 760570005138 putative DNA binding site [nucleotide binding]; other site 760570005139 putative metal binding site [ion binding]; other site 760570005140 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 760570005141 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 760570005142 active site 760570005143 DNA binding site [nucleotide binding] 760570005144 catalytic site [active] 760570005145 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 760570005146 Protein of unknown function (DUF975); Region: DUF975; cl10504 760570005147 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 760570005148 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 760570005149 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 760570005150 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 760570005151 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 760570005152 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 760570005153 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 760570005154 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 760570005155 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 760570005156 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 760570005157 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 760570005158 putative translocon binding site; other site 760570005159 protein-rRNA interface [nucleotide binding]; other site 760570005160 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 760570005161 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 760570005162 G-X-X-G motif; other site 760570005163 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 760570005164 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 760570005165 23S rRNA interface [nucleotide binding]; other site 760570005166 5S rRNA interface [nucleotide binding]; other site 760570005167 putative antibiotic binding site [chemical binding]; other site 760570005168 L25 interface [polypeptide binding]; other site 760570005169 L27 interface [polypeptide binding]; other site 760570005170 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 760570005171 23S rRNA interface [nucleotide binding]; other site 760570005172 putative translocon interaction site; other site 760570005173 signal recognition particle (SRP54) interaction site; other site 760570005174 L23 interface [polypeptide binding]; other site 760570005175 trigger factor interaction site; other site 760570005176 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 760570005177 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 760570005178 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 760570005179 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 760570005180 RNA binding site [nucleotide binding]; other site 760570005181 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 760570005182 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 760570005183 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 760570005184 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 760570005185 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 760570005186 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 760570005187 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 760570005188 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 760570005189 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 760570005190 5S rRNA interface [nucleotide binding]; other site 760570005191 L27 interface [polypeptide binding]; other site 760570005192 23S rRNA interface [nucleotide binding]; other site 760570005193 L5 interface [polypeptide binding]; other site 760570005194 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 760570005195 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 760570005196 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 760570005197 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 760570005198 23S rRNA binding site [nucleotide binding]; other site 760570005199 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 760570005200 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 760570005201 SecY translocase; Region: SecY; pfam00344 760570005202 adenylate kinase; Reviewed; Region: adk; PRK00279 760570005203 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 760570005204 AMP-binding site [chemical binding]; other site 760570005205 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 760570005206 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 760570005207 rRNA binding site [nucleotide binding]; other site 760570005208 predicted 30S ribosome binding site; other site 760570005209 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 760570005210 30S ribosomal protein S13; Region: bact_S13; TIGR03631 760570005211 30S ribosomal protein S11; Validated; Region: PRK05309 760570005212 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 760570005213 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 760570005214 alphaNTD homodimer interface [polypeptide binding]; other site 760570005215 alphaNTD - beta interaction site [polypeptide binding]; other site 760570005216 alphaNTD - beta' interaction site [polypeptide binding]; other site 760570005217 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 760570005218 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 760570005219 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 760570005220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570005221 putative substrate translocation pore; other site 760570005222 H+ Antiporter protein; Region: 2A0121; TIGR00900 760570005223 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 760570005224 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760570005225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760570005226 putative DNA binding site [nucleotide binding]; other site 760570005227 putative Zn2+ binding site [ion binding]; other site 760570005228 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760570005229 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 760570005230 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 760570005231 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 760570005232 ABC-ATPase subunit interface; other site 760570005233 dimer interface [polypeptide binding]; other site 760570005234 putative PBP binding regions; other site 760570005235 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 760570005236 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 760570005237 metal binding site [ion binding]; metal-binding site 760570005238 YodA lipocalin-like domain; Region: YodA; pfam09223 760570005239 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 760570005240 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 760570005241 Uncharacterized conserved protein [Function unknown]; Region: COG3538 760570005242 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 760570005243 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 760570005244 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 760570005245 active site 760570005246 metal binding site [ion binding]; metal-binding site 760570005247 homodimer interface [polypeptide binding]; other site 760570005248 catalytic site [active] 760570005249 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 760570005250 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760570005251 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760570005252 nucleotide binding site [chemical binding]; other site 760570005253 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 760570005254 putative active site [active] 760570005255 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760570005256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570005257 dimer interface [polypeptide binding]; other site 760570005258 conserved gate region; other site 760570005259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 760570005260 ABC-ATPase subunit interface; other site 760570005261 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760570005262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570005263 dimer interface [polypeptide binding]; other site 760570005264 conserved gate region; other site 760570005265 putative PBP binding loops; other site 760570005266 ABC-ATPase subunit interface; other site 760570005267 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760570005268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760570005269 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 760570005270 Protein of unknown function, DUF624; Region: DUF624; cl02369 760570005271 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760570005272 Histidine kinase; Region: His_kinase; pfam06580 760570005273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570005274 ATP binding site [chemical binding]; other site 760570005275 Mg2+ binding site [ion binding]; other site 760570005276 G-X-G motif; other site 760570005277 potential frameshift: common BLAST hit: gi|225853781|ref|YP_002735293.1| response regulator 760570005278 Response regulator receiver domain; Region: Response_reg; pfam00072 760570005279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570005280 active site 760570005281 phosphorylation site [posttranslational modification] 760570005282 intermolecular recognition site; other site 760570005283 dimerization interface [polypeptide binding]; other site 760570005284 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760570005285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760570005286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760570005287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760570005288 WHG domain; Region: WHG; pfam13305 760570005289 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 760570005290 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760570005291 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 760570005292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570005293 S-adenosylmethionine binding site [chemical binding]; other site 760570005294 Predicted transcriptional regulators [Transcription]; Region: COG1733 760570005295 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 760570005296 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760570005297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570005298 Walker A/P-loop; other site 760570005299 ATP binding site [chemical binding]; other site 760570005300 Q-loop/lid; other site 760570005301 ABC transporter signature motif; other site 760570005302 Walker B; other site 760570005303 D-loop; other site 760570005304 H-loop/switch region; other site 760570005305 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 760570005306 LytTr DNA-binding domain; Region: LytTR; smart00850 760570005307 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 760570005308 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 760570005309 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 760570005310 active site 760570005311 HIGH motif; other site 760570005312 dimer interface [polypeptide binding]; other site 760570005313 KMSKS motif; other site 760570005314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760570005315 RNA binding surface [nucleotide binding]; other site 760570005316 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 760570005317 Transglycosylase; Region: Transgly; pfam00912 760570005318 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 760570005319 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 760570005320 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 760570005321 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 760570005322 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 760570005323 RPB1 interaction site [polypeptide binding]; other site 760570005324 RPB10 interaction site [polypeptide binding]; other site 760570005325 RPB11 interaction site [polypeptide binding]; other site 760570005326 RPB3 interaction site [polypeptide binding]; other site 760570005327 RPB12 interaction site [polypeptide binding]; other site 760570005328 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 760570005329 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 760570005330 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 760570005331 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 760570005332 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 760570005333 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 760570005334 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 760570005335 G-loop; other site 760570005336 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 760570005337 DNA binding site [nucleotide binding] 760570005338 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 760570005339 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 760570005340 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 760570005341 active site 760570005342 homodimer interface [polypeptide binding]; other site 760570005343 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760570005344 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 760570005345 DXD motif; other site 760570005346 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 760570005347 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 760570005348 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 760570005349 Walker A motif; other site 760570005350 ATP binding site [chemical binding]; other site 760570005351 Walker B motif; other site 760570005352 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 760570005353 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 760570005354 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 760570005355 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 760570005356 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 760570005357 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 760570005358 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 760570005359 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 760570005360 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 760570005361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570005362 S-adenosylmethionine binding site [chemical binding]; other site 760570005363 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 760570005364 propionate/acetate kinase; Provisional; Region: PRK12379 760570005365 CAAX protease self-immunity; Region: Abi; pfam02517 760570005366 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 760570005367 dihydropteroate synthase; Region: DHPS; TIGR01496 760570005368 substrate binding pocket [chemical binding]; other site 760570005369 dimer interface [polypeptide binding]; other site 760570005370 inhibitor binding site; inhibition site 760570005371 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 760570005372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760570005373 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760570005374 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 760570005375 homodecamer interface [polypeptide binding]; other site 760570005376 GTP cyclohydrolase I; Provisional; Region: PLN03044 760570005377 active site 760570005378 putative catalytic site residues [active] 760570005379 zinc binding site [ion binding]; other site 760570005380 GTP-CH-I/GFRP interaction surface; other site 760570005381 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 760570005382 homooctamer interface [polypeptide binding]; other site 760570005383 active site 760570005384 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 760570005385 catalytic center binding site [active] 760570005386 ATP binding site [chemical binding]; other site 760570005387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 760570005388 hypothetical protein; Provisional; Region: PRK13663 760570005389 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 760570005390 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 760570005391 oligomer interface [polypeptide binding]; other site 760570005392 active site 760570005393 metal binding site [ion binding]; metal-binding site 760570005394 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760570005395 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760570005396 catalytic residues [active] 760570005397 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 760570005398 putative tRNA-binding site [nucleotide binding]; other site 760570005399 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 760570005400 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 760570005401 dimer interface [polypeptide binding]; other site 760570005402 ssDNA binding site [nucleotide binding]; other site 760570005403 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760570005404 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 760570005405 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 760570005406 ligand binding site [chemical binding]; other site 760570005407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760570005408 Histidine kinase; Region: HisKA_3; pfam07730 760570005409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570005410 ATP binding site [chemical binding]; other site 760570005411 Mg2+ binding site [ion binding]; other site 760570005412 G-X-G motif; other site 760570005413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760570005414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570005415 active site 760570005416 phosphorylation site [posttranslational modification] 760570005417 intermolecular recognition site; other site 760570005418 dimerization interface [polypeptide binding]; other site 760570005419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760570005420 DNA binding residues [nucleotide binding] 760570005421 dimerization interface [polypeptide binding]; other site 760570005422 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760570005423 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760570005424 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 760570005425 active pocket/dimerization site; other site 760570005426 active site 760570005427 phosphorylation site [posttranslational modification] 760570005428 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 760570005429 active site 760570005430 phosphorylation site [posttranslational modification] 760570005431 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 760570005432 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 760570005433 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 760570005434 oligomerisation interface [polypeptide binding]; other site 760570005435 mobile loop; other site 760570005436 roof hairpin; other site 760570005437 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 760570005438 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 760570005439 ring oligomerisation interface [polypeptide binding]; other site 760570005440 ATP/Mg binding site [chemical binding]; other site 760570005441 stacking interactions; other site 760570005442 hinge regions; other site 760570005443 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760570005444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 760570005445 active site 760570005446 phosphorylation site [posttranslational modification] 760570005447 intermolecular recognition site; other site 760570005448 dimerization interface [polypeptide binding]; other site 760570005449 LytTr DNA-binding domain; Region: LytTR; pfam04397 760570005450 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760570005451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570005452 ATP binding site [chemical binding]; other site 760570005453 Mg2+ binding site [ion binding]; other site 760570005454 G-X-G motif; other site 760570005455 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 760570005456 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760570005457 Walker A/P-loop; other site 760570005458 ATP binding site [chemical binding]; other site 760570005459 Q-loop/lid; other site 760570005460 ABC transporter signature motif; other site 760570005461 Walker B; other site 760570005462 D-loop; other site 760570005463 H-loop/switch region; other site 760570005464 recombination factor protein RarA; Reviewed; Region: PRK13342 760570005465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570005466 Walker A motif; other site 760570005467 ATP binding site [chemical binding]; other site 760570005468 Walker B motif; other site 760570005469 arginine finger; other site 760570005470 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 760570005471 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 760570005472 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 760570005473 nudix motif; other site 760570005474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760570005475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570005476 Coenzyme A binding pocket [chemical binding]; other site 760570005477 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 760570005478 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 760570005479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570005480 S-adenosylmethionine binding site [chemical binding]; other site 760570005481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 760570005482 RNA methyltransferase, RsmE family; Region: TIGR00046 760570005483 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 760570005484 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 760570005485 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 760570005486 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760570005487 Zn2+ binding site [ion binding]; other site 760570005488 Mg2+ binding site [ion binding]; other site 760570005489 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 760570005490 synthetase active site [active] 760570005491 NTP binding site [chemical binding]; other site 760570005492 metal binding site [ion binding]; metal-binding site 760570005493 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 760570005494 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 760570005495 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 760570005496 putative active site [active] 760570005497 dimerization interface [polypeptide binding]; other site 760570005498 putative tRNAtyr binding site [nucleotide binding]; other site 760570005499 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 760570005500 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 760570005501 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 760570005502 FeoA domain; Region: FeoA; pfam04023 760570005503 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 760570005504 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 760570005505 dimer interface [polypeptide binding]; other site 760570005506 catalytic triad [active] 760570005507 peroxidatic and resolving cysteines [active] 760570005508 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 760570005509 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 760570005510 metal binding site [ion binding]; metal-binding site 760570005511 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 760570005512 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 760570005513 ABC-ATPase subunit interface; other site 760570005514 dimer interface [polypeptide binding]; other site 760570005515 putative PBP binding regions; other site 760570005516 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 760570005517 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 760570005518 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 760570005519 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 760570005520 active site 760570005521 Zn binding site [ion binding]; other site 760570005522 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 760570005523 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 760570005524 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 760570005525 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 760570005526 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 760570005527 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760570005528 non-specific DNA interactions [nucleotide binding]; other site 760570005529 DNA binding site [nucleotide binding] 760570005530 sequence specific DNA binding site [nucleotide binding]; other site 760570005531 putative cAMP binding site [chemical binding]; other site 760570005532 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 760570005533 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 760570005534 active site 760570005535 methionine cluster; other site 760570005536 phosphorylation site [posttranslational modification] 760570005537 metal binding site [ion binding]; metal-binding site 760570005538 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 760570005539 active site 760570005540 P-loop; other site 760570005541 phosphorylation site [posttranslational modification] 760570005542 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 760570005543 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 760570005544 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 760570005545 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 760570005546 dimer interface [polypeptide binding]; other site 760570005547 active site 760570005548 glycine loop; other site 760570005549 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 760570005550 active site 760570005551 intersubunit interactions; other site 760570005552 catalytic residue [active] 760570005553 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 760570005554 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 760570005555 dimer interface [polypeptide binding]; other site 760570005556 active site 760570005557 metal binding site [ion binding]; metal-binding site 760570005558 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 760570005559 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 760570005560 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 760570005561 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 760570005562 peptide binding site [polypeptide binding]; other site 760570005563 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 760570005564 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 760570005565 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 760570005566 HIGH motif; other site 760570005567 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 760570005568 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760570005569 active site 760570005570 KMSKS motif; other site 760570005571 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 760570005572 tRNA binding surface [nucleotide binding]; other site 760570005573 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 760570005574 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 760570005575 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 760570005576 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 760570005577 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 760570005578 putative ADP-ribose binding site [chemical binding]; other site 760570005579 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760570005580 dimerization interface [polypeptide binding]; other site 760570005581 putative Zn2+ binding site [ion binding]; other site 760570005582 putative DNA binding site [nucleotide binding]; other site 760570005583 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 760570005584 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 760570005585 NADP binding site [chemical binding]; other site 760570005586 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 760570005587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570005588 Walker A/P-loop; other site 760570005589 ATP binding site [chemical binding]; other site 760570005590 Q-loop/lid; other site 760570005591 ABC transporter signature motif; other site 760570005592 Walker B; other site 760570005593 D-loop; other site 760570005594 H-loop/switch region; other site 760570005595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570005596 dimer interface [polypeptide binding]; other site 760570005597 conserved gate region; other site 760570005598 ABC-ATPase subunit interface; other site 760570005599 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 760570005600 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 760570005601 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 760570005602 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 760570005603 catalytic triad [active] 760570005604 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 760570005605 beta-galactosidase; Region: BGL; TIGR03356 760570005606 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 760570005607 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 760570005608 glutaminase active site [active] 760570005609 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 760570005610 dimer interface [polypeptide binding]; other site 760570005611 active site 760570005612 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 760570005613 dimer interface [polypeptide binding]; other site 760570005614 active site 760570005615 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 760570005616 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 760570005617 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 760570005618 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 760570005619 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760570005620 substrate binding pocket [chemical binding]; other site 760570005621 membrane-bound complex binding site; other site 760570005622 hinge residues; other site 760570005623 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 760570005624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570005625 dimer interface [polypeptide binding]; other site 760570005626 conserved gate region; other site 760570005627 putative PBP binding loops; other site 760570005628 ABC-ATPase subunit interface; other site 760570005629 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 760570005630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570005631 dimer interface [polypeptide binding]; other site 760570005632 conserved gate region; other site 760570005633 putative PBP binding loops; other site 760570005634 ABC-ATPase subunit interface; other site 760570005635 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 760570005636 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 760570005637 Walker A/P-loop; other site 760570005638 ATP binding site [chemical binding]; other site 760570005639 Q-loop/lid; other site 760570005640 ABC transporter signature motif; other site 760570005641 Walker B; other site 760570005642 D-loop; other site 760570005643 H-loop/switch region; other site 760570005644 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 760570005645 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 760570005646 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 760570005647 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760570005648 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 760570005649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570005650 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760570005651 Walker A motif; other site 760570005652 ATP binding site [chemical binding]; other site 760570005653 Walker B motif; other site 760570005654 arginine finger; other site 760570005655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570005656 Walker A motif; other site 760570005657 ATP binding site [chemical binding]; other site 760570005658 Walker B motif; other site 760570005659 arginine finger; other site 760570005660 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 760570005661 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 760570005662 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 760570005663 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 760570005664 catalytic residue [active] 760570005665 putative FPP diphosphate binding site; other site 760570005666 putative FPP binding hydrophobic cleft; other site 760570005667 dimer interface [polypeptide binding]; other site 760570005668 putative IPP diphosphate binding site; other site 760570005669 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 760570005670 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 760570005671 RIP metalloprotease RseP; Region: TIGR00054 760570005672 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 760570005673 active site 760570005674 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 760570005675 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 760570005676 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 760570005677 putative substrate binding region [chemical binding]; other site 760570005678 prolyl-tRNA synthetase; Provisional; Region: PRK09194 760570005679 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 760570005680 dimer interface [polypeptide binding]; other site 760570005681 motif 1; other site 760570005682 active site 760570005683 motif 2; other site 760570005684 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 760570005685 putative deacylase active site [active] 760570005686 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 760570005687 active site 760570005688 motif 3; other site 760570005689 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 760570005690 anticodon binding site; other site 760570005691 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 760570005692 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 760570005693 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 760570005694 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 760570005695 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 760570005696 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 760570005697 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 760570005698 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 760570005699 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 760570005700 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 760570005701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570005702 Walker A motif; other site 760570005703 ATP binding site [chemical binding]; other site 760570005704 Walker B motif; other site 760570005705 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 760570005706 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 760570005707 DNA polymerase III PolC; Validated; Region: polC; PRK00448 760570005708 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 760570005709 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 760570005710 generic binding surface II; other site 760570005711 generic binding surface I; other site 760570005712 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 760570005713 active site 760570005714 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 760570005715 active site 760570005716 catalytic site [active] 760570005717 substrate binding site [chemical binding]; other site 760570005718 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 760570005719 putative PHP Thumb interface [polypeptide binding]; other site 760570005720 active site 760570005721 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 760570005722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 760570005723 stage V sporulation protein K; Region: spore_V_K; TIGR02881 760570005724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570005725 Walker A motif; other site 760570005726 ATP binding site [chemical binding]; other site 760570005727 Walker B motif; other site 760570005728 arginine finger; other site 760570005729 stage V sporulation protein K; Region: spore_V_K; TIGR02881 760570005730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570005731 Walker A motif; other site 760570005732 ATP binding site [chemical binding]; other site 760570005733 Walker B motif; other site 760570005734 arginine finger; other site 760570005735 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 760570005736 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 760570005737 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 760570005738 active site 760570005739 catalytic residues [active] 760570005740 metal binding site [ion binding]; metal-binding site 760570005741 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 760570005742 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760570005743 ligand binding site [chemical binding]; other site 760570005744 flexible hinge region; other site 760570005745 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 760570005746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570005747 putative substrate translocation pore; other site 760570005748 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760570005749 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760570005750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760570005751 putative substrate translocation pore; other site 760570005752 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 760570005753 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760570005754 RNA binding surface [nucleotide binding]; other site 760570005755 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 760570005756 active site 760570005757 uracil binding [chemical binding]; other site 760570005758 Cna protein B-type domain; Region: Cna_B; pfam05738 760570005759 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 760570005760 domain interaction interfaces [polypeptide binding]; other site 760570005761 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 760570005762 domain interaction interfaces [polypeptide binding]; other site 760570005763 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 760570005764 16S/18S rRNA binding site [nucleotide binding]; other site 760570005765 S13e-L30e interaction site [polypeptide binding]; other site 760570005766 25S rRNA binding site [nucleotide binding]; other site 760570005767 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760570005768 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760570005769 catalytic residues [active] 760570005770 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760570005771 catalytic residues [active] 760570005772 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 760570005773 oligoendopeptidase F; Region: pepF; TIGR00181 760570005774 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 760570005775 Zn binding site [ion binding]; other site 760570005776 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 760570005777 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 760570005778 RNase E interface [polypeptide binding]; other site 760570005779 trimer interface [polypeptide binding]; other site 760570005780 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 760570005781 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 760570005782 RNase E interface [polypeptide binding]; other site 760570005783 trimer interface [polypeptide binding]; other site 760570005784 active site 760570005785 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 760570005786 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 760570005787 RNA binding site [nucleotide binding]; other site 760570005788 domain interface; other site 760570005789 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 760570005790 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 760570005791 trimer interface [polypeptide binding]; other site 760570005792 active site 760570005793 substrate binding site [chemical binding]; other site 760570005794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570005795 Coenzyme A binding pocket [chemical binding]; other site 760570005796 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 760570005797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570005798 Coenzyme A binding pocket [chemical binding]; other site 760570005799 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 760570005800 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 760570005801 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 760570005802 active site 760570005803 HIGH motif; other site 760570005804 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 760570005805 KMSKS motif; other site 760570005806 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 760570005807 tRNA binding surface [nucleotide binding]; other site 760570005808 anticodon binding site; other site 760570005809 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 760570005810 active site 760570005811 metal binding site [ion binding]; metal-binding site 760570005812 dimerization interface [polypeptide binding]; other site 760570005813 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 760570005814 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 760570005815 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 760570005816 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 760570005817 Walker A/P-loop; other site 760570005818 ATP binding site [chemical binding]; other site 760570005819 Q-loop/lid; other site 760570005820 ABC transporter signature motif; other site 760570005821 Walker B; other site 760570005822 D-loop; other site 760570005823 H-loop/switch region; other site 760570005824 TOBE domain; Region: TOBE_2; pfam08402 760570005825 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 760570005826 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 760570005827 Ca binding site [ion binding]; other site 760570005828 active site 760570005829 catalytic site [active] 760570005830 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 760570005831 active site 760570005832 Zn binding site [ion binding]; other site 760570005833 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 760570005834 Predicted membrane protein [Function unknown]; Region: COG4129 760570005835 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 760570005836 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 760570005837 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 760570005838 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 760570005839 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 760570005840 YacP-like NYN domain; Region: NYN_YacP; pfam05991 760570005841 EDD domain protein, DegV family; Region: DegV; TIGR00762 760570005842 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 760570005843 Ribosomal protein L13 leader; HMPREF0833_nc10023 760570005844 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 760570005845 23S rRNA interface [nucleotide binding]; other site 760570005846 L3 interface [polypeptide binding]; other site 760570005847 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 760570005848 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760570005849 active site 760570005850 DNA binding site [nucleotide binding] 760570005851 Int/Topo IB signature motif; other site 760570005852 Helix-turn-helix domain; Region: HTH_17; pfam12728 760570005853 Plasmid replication protein; Region: Rep_2; pfam01719 760570005854 potential frameshift: common BLAST hit: gi|336065196|ref|YP_004560055.1| FtsK/SpoIIIE family protein 760570005855 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 760570005856 DNA polymerase III PolC; Validated; Region: polC; PRK00448 760570005857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760570005858 dimerization interface [polypeptide binding]; other site 760570005859 putative DNA binding site [nucleotide binding]; other site 760570005860 putative Zn2+ binding site [ion binding]; other site 760570005861 Predicted permeases [General function prediction only]; Region: COG0701 760570005862 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 760570005863 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 760570005864 ArsC family; Region: ArsC; pfam03960 760570005865 catalytic residues [active] 760570005866 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 760570005867 Int/Topo IB signature motif; other site 760570005868 Plasmid replication protein; Region: Rep_2; pfam01719 760570005869 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 760570005870 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760570005871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760570005872 Walker A motif; other site 760570005873 ATP binding site [chemical binding]; other site 760570005874 Walker B motif; other site 760570005875 arginine finger; other site 760570005876 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 760570005877 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760570005878 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760570005879 Walker A/P-loop; other site 760570005880 ATP binding site [chemical binding]; other site 760570005881 Q-loop/lid; other site 760570005882 ABC transporter signature motif; other site 760570005883 Walker B; other site 760570005884 D-loop; other site 760570005885 H-loop/switch region; other site 760570005886 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 760570005887 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 760570005888 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 760570005889 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 760570005890 Int/Topo IB signature motif; other site 760570005891 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 760570005892 DNA binding residues [nucleotide binding] 760570005893 Surface antigen [General function prediction only]; Region: COG3942 760570005894 CHAP domain; Region: CHAP; pfam05257 760570005895 AAA-like domain; Region: AAA_10; pfam12846 760570005896 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 760570005897 Walker A motif; other site 760570005898 ATP binding site [chemical binding]; other site 760570005899 TcpE family; Region: TcpE; pfam12648 760570005900 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 760570005901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570005902 non-specific DNA binding site [nucleotide binding]; other site 760570005903 salt bridge; other site 760570005904 sequence-specific DNA binding site [nucleotide binding]; other site 760570005905 Replication initiation factor; Region: Rep_trans; pfam02486 760570005906 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 760570005907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570005908 non-specific DNA binding site [nucleotide binding]; other site 760570005909 salt bridge; other site 760570005910 sequence-specific DNA binding site [nucleotide binding]; other site 760570005911 Domain of unknown function (DUF955); Region: DUF955; pfam06114 760570005912 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 760570005913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570005914 sequence-specific DNA binding site [nucleotide binding]; other site 760570005915 salt bridge; other site 760570005916 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760570005917 Catalytic site [active] 760570005918 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760570005919 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 760570005920 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 760570005921 Walker A/P-loop; other site 760570005922 ATP binding site [chemical binding]; other site 760570005923 Q-loop/lid; other site 760570005924 ABC transporter signature motif; other site 760570005925 Walker B; other site 760570005926 D-loop; other site 760570005927 H-loop/switch region; other site 760570005928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570005929 non-specific DNA binding site [nucleotide binding]; other site 760570005930 salt bridge; other site 760570005931 sequence-specific DNA binding site [nucleotide binding]; other site 760570005932 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 760570005933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760570005934 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 760570005935 Walker A/P-loop; other site 760570005936 ATP binding site [chemical binding]; other site 760570005937 Q-loop/lid; other site 760570005938 ABC transporter signature motif; other site 760570005939 Walker B; other site 760570005940 D-loop; other site 760570005941 H-loop/switch region; other site 760570005942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 760570005943 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 760570005944 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 760570005945 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760570005946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570005947 non-specific DNA binding site [nucleotide binding]; other site 760570005948 salt bridge; other site 760570005949 sequence-specific DNA binding site [nucleotide binding]; other site 760570005950 Fic/DOC family; Region: Fic; cl00960 760570005951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760570005952 non-specific DNA binding site [nucleotide binding]; other site 760570005953 salt bridge; other site 760570005954 sequence-specific DNA binding site [nucleotide binding]; other site 760570005955 PspC domain; Region: PspC; pfam04024 760570005956 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 760570005957 CsbD-like; Region: CsbD; cl17424 760570005958 Rhomboid family; Region: Rhomboid; cl11446 760570005959 VanZ like family; Region: VanZ; pfam04892 760570005960 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 760570005961 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 760570005962 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760570005963 catalytic core [active] 760570005964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760570005965 catalytic core [active] 760570005966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760570005967 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 760570005968 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 760570005969 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 760570005970 GrpE; Region: GrpE; pfam01025 760570005971 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 760570005972 dimer interface [polypeptide binding]; other site 760570005973 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 760570005974 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 760570005975 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 760570005976 nucleotide binding site [chemical binding]; other site 760570005977 NEF interaction site [polypeptide binding]; other site 760570005978 SBD interface [polypeptide binding]; other site 760570005979 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 760570005980 conserved cys residue [active] 760570005981 chaperone protein DnaJ; Provisional; Region: PRK14276 760570005982 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 760570005983 HSP70 interaction site [polypeptide binding]; other site 760570005984 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 760570005985 substrate binding site [polypeptide binding]; other site 760570005986 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 760570005987 Zn binding sites [ion binding]; other site 760570005988 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 760570005989 dimer interface [polypeptide binding]; other site 760570005990 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 760570005991 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 760570005992 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 760570005993 active site 760570005994 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 760570005995 active site 760570005996 G5 domain; Region: G5; pfam07501 760570005997 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 760570005998 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 760570005999 dimerization interface 3.5A [polypeptide binding]; other site 760570006000 active site 760570006001 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 760570006002 substrate binding site [chemical binding]; other site 760570006003 dimer interface [polypeptide binding]; other site 760570006004 ATP binding site [chemical binding]; other site 760570006005 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 760570006006 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 760570006007 hypothetical protein; Provisional; Region: PRK13690 760570006008 trigger factor; Provisional; Region: tig; PRK01490 760570006009 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760570006010 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 760570006011 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 760570006012 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 760570006013 B3/4 domain; Region: B3_4; pfam03483 760570006014 CTP synthetase; Validated; Region: pyrG; PRK05380 760570006015 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 760570006016 Catalytic site [active] 760570006017 active site 760570006018 UTP binding site [chemical binding]; other site 760570006019 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 760570006020 active site 760570006021 putative oxyanion hole; other site 760570006022 catalytic triad [active] 760570006023 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 760570006024 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 760570006025 intersubunit interface [polypeptide binding]; other site 760570006026 active site 760570006027 zinc binding site [ion binding]; other site 760570006028 Na+ binding site [ion binding]; other site 760570006029 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760570006030 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760570006031 catalytic core [active] 760570006032 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 760570006033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570006034 Walker A/P-loop; other site 760570006035 ATP binding site [chemical binding]; other site 760570006036 Q-loop/lid; other site 760570006037 ABC transporter signature motif; other site 760570006038 Walker B; other site 760570006039 D-loop; other site 760570006040 H-loop/switch region; other site 760570006041 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 760570006042 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 760570006043 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 760570006044 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 760570006045 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 760570006046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760570006047 Coenzyme A binding pocket [chemical binding]; other site 760570006048 LytTr DNA-binding domain; Region: LytTR; smart00850 760570006049 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 760570006050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 760570006051 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 760570006052 DAK2 domain; Region: Dak2; pfam02734 760570006053 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760570006054 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760570006055 Walker A/P-loop; other site 760570006056 ATP binding site [chemical binding]; other site 760570006057 Q-loop/lid; other site 760570006058 ABC transporter signature motif; other site 760570006059 Walker B; other site 760570006060 D-loop; other site 760570006061 H-loop/switch region; other site 760570006062 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 760570006063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760570006064 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 760570006065 Histidine kinase; Region: HisKA_3; pfam07730 760570006066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 760570006067 ATP binding site [chemical binding]; other site 760570006068 Mg2+ binding site [ion binding]; other site 760570006069 G-X-G motif; other site 760570006070 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760570006071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570006072 active site 760570006073 phosphorylation site [posttranslational modification] 760570006074 intermolecular recognition site; other site 760570006075 dimerization interface [polypeptide binding]; other site 760570006076 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760570006077 DNA binding residues [nucleotide binding] 760570006078 dimerization interface [polypeptide binding]; other site 760570006079 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 760570006080 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 760570006081 PYR/PP interface [polypeptide binding]; other site 760570006082 dimer interface [polypeptide binding]; other site 760570006083 TPP binding site [chemical binding]; other site 760570006084 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 760570006085 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 760570006086 TPP-binding site [chemical binding]; other site 760570006087 dimer interface [polypeptide binding]; other site 760570006088 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 760570006089 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 760570006090 putative valine binding site [chemical binding]; other site 760570006091 dimer interface [polypeptide binding]; other site 760570006092 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 760570006093 ketol-acid reductoisomerase; Provisional; Region: PRK05479 760570006094 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 760570006095 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 760570006096 threonine dehydratase; Validated; Region: PRK08639 760570006097 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 760570006098 tetramer interface [polypeptide binding]; other site 760570006099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760570006100 catalytic residue [active] 760570006101 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 760570006102 HflK protein; Region: hflK; TIGR01933 760570006103 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 760570006104 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 760570006105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760570006106 Walker A/P-loop; other site 760570006107 ATP binding site [chemical binding]; other site 760570006108 Q-loop/lid; other site 760570006109 ABC transporter signature motif; other site 760570006110 Walker B; other site 760570006111 D-loop; other site 760570006112 H-loop/switch region; other site 760570006113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760570006114 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 760570006115 substrate binding pocket [chemical binding]; other site 760570006116 membrane-bound complex binding site; other site 760570006117 hinge residues; other site 760570006118 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 760570006119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570006120 dimer interface [polypeptide binding]; other site 760570006121 conserved gate region; other site 760570006122 putative PBP binding loops; other site 760570006123 ABC-ATPase subunit interface; other site 760570006124 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 760570006125 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 760570006126 adaptor protein; Provisional; Region: PRK02315 760570006127 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 760570006128 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 760570006129 Mg++ binding site [ion binding]; other site 760570006130 putative catalytic motif [active] 760570006131 substrate binding site [chemical binding]; other site 760570006132 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 760570006133 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 760570006134 Walker A/P-loop; other site 760570006135 ATP binding site [chemical binding]; other site 760570006136 Q-loop/lid; other site 760570006137 ABC transporter signature motif; other site 760570006138 Walker B; other site 760570006139 D-loop; other site 760570006140 H-loop/switch region; other site 760570006141 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 760570006142 FeS assembly protein SufD; Region: sufD; TIGR01981 760570006143 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 760570006144 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 760570006145 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760570006146 catalytic residue [active] 760570006147 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 760570006148 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 760570006149 trimerization site [polypeptide binding]; other site 760570006150 active site 760570006151 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 760570006152 FeS assembly protein SufB; Region: sufB; TIGR01980 760570006153 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 760570006154 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 760570006155 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 760570006156 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 760570006157 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 760570006158 peptide binding site [polypeptide binding]; other site 760570006159 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 760570006160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570006161 dimer interface [polypeptide binding]; other site 760570006162 conserved gate region; other site 760570006163 putative PBP binding loops; other site 760570006164 ABC-ATPase subunit interface; other site 760570006165 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 760570006166 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 760570006167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570006168 dimer interface [polypeptide binding]; other site 760570006169 conserved gate region; other site 760570006170 putative PBP binding loops; other site 760570006171 ABC-ATPase subunit interface; other site 760570006172 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 760570006173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 760570006174 Walker A/P-loop; other site 760570006175 ATP binding site [chemical binding]; other site 760570006176 Q-loop/lid; other site 760570006177 ABC transporter signature motif; other site 760570006178 Walker B; other site 760570006179 D-loop; other site 760570006180 H-loop/switch region; other site 760570006181 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 760570006182 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 760570006183 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 760570006184 Walker A/P-loop; other site 760570006185 ATP binding site [chemical binding]; other site 760570006186 Q-loop/lid; other site 760570006187 ABC transporter signature motif; other site 760570006188 Walker B; other site 760570006189 D-loop; other site 760570006190 H-loop/switch region; other site 760570006191 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 760570006192 potential frameshift truncated IS1193 transposase 760570006193 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 760570006194 aspartate kinase; Reviewed; Region: PRK09034 760570006195 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 760570006196 putative catalytic residues [active] 760570006197 putative nucleotide binding site [chemical binding]; other site 760570006198 putative aspartate binding site [chemical binding]; other site 760570006199 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 760570006200 allosteric regulatory residue; other site 760570006201 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 760570006202 enoyl-CoA hydratase; Provisional; Region: PRK07260 760570006203 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 760570006204 substrate binding site [chemical binding]; other site 760570006205 oxyanion hole (OAH) forming residues; other site 760570006206 trimer interface [polypeptide binding]; other site 760570006207 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760570006208 MarR family; Region: MarR_2; pfam12802 760570006209 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 760570006210 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 760570006211 dimer interface [polypeptide binding]; other site 760570006212 active site 760570006213 CoA binding pocket [chemical binding]; other site 760570006214 acyl carrier protein; Provisional; Region: acpP; PRK00982 760570006215 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 760570006216 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 760570006217 FMN binding site [chemical binding]; other site 760570006218 substrate binding site [chemical binding]; other site 760570006219 putative catalytic residue [active] 760570006220 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 760570006221 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 760570006222 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 760570006223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760570006224 NAD(P) binding site [chemical binding]; other site 760570006225 active site 760570006226 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 760570006227 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 760570006228 dimer interface [polypeptide binding]; other site 760570006229 active site 760570006230 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 760570006231 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 760570006232 carboxyltransferase (CT) interaction site; other site 760570006233 biotinylation site [posttranslational modification]; other site 760570006234 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 760570006235 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 760570006236 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 760570006237 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 760570006238 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 760570006239 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 760570006240 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 760570006241 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 760570006242 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 760570006243 seryl-tRNA synthetase; Provisional; Region: PRK05431 760570006244 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 760570006245 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 760570006246 dimer interface [polypeptide binding]; other site 760570006247 active site 760570006248 motif 1; other site 760570006249 motif 2; other site 760570006250 motif 3; other site 760570006251 T-box leader; HMPREF0833_nc10025 760570006252 Domain of unknown function (DUF956); Region: DUF956; pfam06115 760570006253 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 760570006254 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 760570006255 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 760570006256 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 760570006257 active pocket/dimerization site; other site 760570006258 active site 760570006259 phosphorylation site [posttranslational modification] 760570006260 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 760570006261 active site 760570006262 phosphorylation site [posttranslational modification] 760570006263 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 760570006264 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 760570006265 NAD binding site [chemical binding]; other site 760570006266 substrate binding site [chemical binding]; other site 760570006267 catalytic Zn binding site [ion binding]; other site 760570006268 tetramer interface [polypeptide binding]; other site 760570006269 structural Zn binding site [ion binding]; other site 760570006270 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 760570006271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570006272 active site 760570006273 motif I; other site 760570006274 motif II; other site 760570006275 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 760570006276 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 760570006277 Sulfate transporter family; Region: Sulfate_transp; pfam00916 760570006278 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 760570006279 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 760570006280 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760570006281 Transcriptional regulator [Transcription]; Region: LytR; COG1316 760570006282 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 760570006283 HIT family signature motif; other site 760570006284 catalytic residue [active] 760570006285 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760570006286 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760570006287 Walker A/P-loop; other site 760570006288 ATP binding site [chemical binding]; other site 760570006289 Q-loop/lid; other site 760570006290 ABC transporter signature motif; other site 760570006291 Walker B; other site 760570006292 D-loop; other site 760570006293 H-loop/switch region; other site 760570006294 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 760570006295 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 760570006296 Phosphotransferase enzyme family; Region: APH; pfam01636 760570006297 active site 760570006298 ATP binding site [chemical binding]; other site 760570006299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760570006300 S-adenosylmethionine binding site [chemical binding]; other site 760570006301 ribosome maturation protein RimP; Reviewed; Region: PRK00092 760570006302 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 760570006303 putative oligomer interface [polypeptide binding]; other site 760570006304 putative RNA binding site [nucleotide binding]; other site 760570006305 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 760570006306 NusA N-terminal domain; Region: NusA_N; pfam08529 760570006307 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 760570006308 RNA binding site [nucleotide binding]; other site 760570006309 homodimer interface [polypeptide binding]; other site 760570006310 NusA-like KH domain; Region: KH_5; pfam13184 760570006311 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 760570006312 G-X-X-G motif; other site 760570006313 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 760570006314 putative RNA binding cleft [nucleotide binding]; other site 760570006315 hypothetical protein; Provisional; Region: PRK07283 760570006316 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 760570006317 translation initiation factor IF-2; Region: IF-2; TIGR00487 760570006318 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 760570006319 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 760570006320 G1 box; other site 760570006321 putative GEF interaction site [polypeptide binding]; other site 760570006322 GTP/Mg2+ binding site [chemical binding]; other site 760570006323 Switch I region; other site 760570006324 G2 box; other site 760570006325 G3 box; other site 760570006326 Switch II region; other site 760570006327 G4 box; other site 760570006328 G5 box; other site 760570006329 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 760570006330 Translation-initiation factor 2; Region: IF-2; pfam11987 760570006331 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 760570006332 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 760570006333 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 760570006334 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 760570006335 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 760570006336 PhoU domain; Region: PhoU; pfam01895 760570006337 PhoU domain; Region: PhoU; pfam01895 760570006338 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 760570006339 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 760570006340 active site 760570006341 dimer interface [polypeptide binding]; other site 760570006342 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760570006343 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760570006344 active site 760570006345 catalytic tetrad [active] 760570006346 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 760570006347 putative active site [active] 760570006348 catalytic triad [active] 760570006349 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 760570006350 PA/protease domain interface [polypeptide binding]; other site 760570006351 putative integrin binding motif; other site 760570006352 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 760570006353 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 760570006354 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 760570006355 dimer interface [polypeptide binding]; other site 760570006356 motif 1; other site 760570006357 active site 760570006358 motif 2; other site 760570006359 motif 3; other site 760570006360 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 760570006361 DALR anticodon binding domain; Region: DALR_1; pfam05746 760570006362 hypothetical protein; Provisional; Region: PRK02539 760570006363 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 760570006364 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 760570006365 MraW methylase family; Region: Methyltransf_5; pfam01795 760570006366 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 760570006367 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 760570006368 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 760570006369 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 760570006370 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 760570006371 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 760570006372 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 760570006373 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 760570006374 Mg++ binding site [ion binding]; other site 760570006375 putative catalytic motif [active] 760570006376 putative substrate binding site [chemical binding]; other site 760570006377 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 760570006378 DEAD-like helicases superfamily; Region: DEXDc; smart00487 760570006379 ATP binding site [chemical binding]; other site 760570006380 Mg++ binding site [ion binding]; other site 760570006381 motif III; other site 760570006382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570006383 nucleotide binding region [chemical binding]; other site 760570006384 ATP-binding site [chemical binding]; other site 760570006385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760570006386 dimer interface [polypeptide binding]; other site 760570006387 conserved gate region; other site 760570006388 putative PBP binding loops; other site 760570006389 ABC-ATPase subunit interface; other site 760570006390 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 760570006391 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 760570006392 Walker A/P-loop; other site 760570006393 ATP binding site [chemical binding]; other site 760570006394 Q-loop/lid; other site 760570006395 ABC transporter signature motif; other site 760570006396 Walker B; other site 760570006397 D-loop; other site 760570006398 H-loop/switch region; other site 760570006399 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 760570006400 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 760570006401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760570006402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760570006403 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 760570006404 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 760570006405 active site 760570006406 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 760570006407 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 760570006408 homodimer interface [polypeptide binding]; other site 760570006409 NAD binding pocket [chemical binding]; other site 760570006410 ATP binding pocket [chemical binding]; other site 760570006411 Mg binding site [ion binding]; other site 760570006412 active-site loop [active] 760570006413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760570006414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 760570006415 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 760570006416 trimer interface [polypeptide binding]; other site 760570006417 active site 760570006418 G bulge; other site 760570006419 Transglycosylase; Region: Transgly; pfam00912 760570006420 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 760570006421 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 760570006422 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 760570006423 hypothetical protein; Provisional; Region: PRK13660 760570006424 cell division protein GpsB; Provisional; Region: PRK14127 760570006425 DivIVA domain; Region: DivI1A_domain; TIGR03544 760570006426 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 760570006427 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 760570006428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 760570006429 S-ribosylhomocysteinase; Provisional; Region: PRK02260 760570006430 hypothetical protein; Provisional; Region: PRK00106 760570006431 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760570006432 Zn2+ binding site [ion binding]; other site 760570006433 Mg2+ binding site [ion binding]; other site 760570006434 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 760570006435 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 760570006436 catalytic site [active] 760570006437 G-X2-G-X-G-K; other site 760570006438 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 760570006439 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 760570006440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760570006441 ATP binding site [chemical binding]; other site 760570006442 putative Mg++ binding site [ion binding]; other site 760570006443 Dof domain, zinc finger; Region: zf-Dof; pfam02701 760570006444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760570006445 nucleotide binding region [chemical binding]; other site 760570006446 ATP-binding site [chemical binding]; other site 760570006447 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 760570006448 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 760570006449 putative active site [active] 760570006450 substrate binding site [chemical binding]; other site 760570006451 putative cosubstrate binding site; other site 760570006452 catalytic site [active] 760570006453 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 760570006454 substrate binding site [chemical binding]; other site 760570006455 16S rRNA methyltransferase B; Provisional; Region: PRK14902 760570006456 NusB family; Region: NusB; pfam01029 760570006457 putative RNA binding site [nucleotide binding]; other site 760570006458 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 760570006459 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 760570006460 active site 760570006461 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 760570006462 Catalytic domain of Protein Kinases; Region: PKc; cd00180 760570006463 active site 760570006464 ATP binding site [chemical binding]; other site 760570006465 substrate binding site [chemical binding]; other site 760570006466 activation loop (A-loop); other site 760570006467 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 760570006468 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 760570006469 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 760570006470 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 760570006471 Predicted membrane protein [Function unknown]; Region: COG4758 760570006472 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 760570006473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760570006474 Histidine kinase; Region: HisKA_3; pfam07730 760570006475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760570006476 ATP binding site [chemical binding]; other site 760570006477 Mg2+ binding site [ion binding]; other site 760570006478 G-X-G motif; other site 760570006479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760570006480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760570006481 active site 760570006482 phosphorylation site [posttranslational modification] 760570006483 intermolecular recognition site; other site 760570006484 dimerization interface [polypeptide binding]; other site 760570006485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760570006486 DNA binding residues [nucleotide binding] 760570006487 dimerization interface [polypeptide binding]; other site 760570006488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760570006489 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 760570006490 active site 760570006491 motif I; other site 760570006492 motif II; other site 760570006493 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 760570006494 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 760570006495 active site 760570006496 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 760570006497 hypothetical protein; Provisional; Region: PRK07252 760570006498 RNA binding site [nucleotide binding]; other site