-- dump date   	20140620_082853
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1076934000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1076934000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934000003	Walker A motif; other site
1076934000004	ATP binding site [chemical binding]; other site
1076934000005	Walker B motif; other site
1076934000006	arginine finger; other site
1076934000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1076934000008	DnaA box-binding interface [nucleotide binding]; other site
1076934000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
1076934000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1076934000011	putative DNA binding surface [nucleotide binding]; other site
1076934000012	dimer interface [polypeptide binding]; other site
1076934000013	beta-clamp/clamp loader binding surface; other site
1076934000014	beta-clamp/translesion DNA polymerase binding surface; other site
1076934000015	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1076934000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
1076934000017	YchF GTPase; Region: YchF; cd01900
1076934000018	G1 box; other site
1076934000019	GTP/Mg2+ binding site [chemical binding]; other site
1076934000020	Switch I region; other site
1076934000021	G2 box; other site
1076934000022	Switch II region; other site
1076934000023	G3 box; other site
1076934000024	G4 box; other site
1076934000025	G5 box; other site
1076934000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1076934000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1076934000028	putative active site [active]
1076934000029	catalytic residue [active]
1076934000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1076934000031	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1076934000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1076934000033	ATP binding site [chemical binding]; other site
1076934000034	putative Mg++ binding site [ion binding]; other site
1076934000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934000036	nucleotide binding region [chemical binding]; other site
1076934000037	ATP-binding site [chemical binding]; other site
1076934000038	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1076934000039	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1076934000040	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934000041	sequence-specific DNA binding site [nucleotide binding]; other site
1076934000042	salt bridge; other site
1076934000043	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1076934000044	RNA binding surface [nucleotide binding]; other site
1076934000045	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1076934000046	Septum formation initiator; Region: DivIC; pfam04977
1076934000047	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1076934000048	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1076934000049	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1076934000050	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1076934000051	Ligand Binding Site [chemical binding]; other site
1076934000052	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1076934000053	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934000054	active site
1076934000055	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
1076934000056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934000057	Walker A motif; other site
1076934000058	ATP binding site [chemical binding]; other site
1076934000059	Walker B motif; other site
1076934000060	arginine finger; other site
1076934000061	Peptidase family M41; Region: Peptidase_M41; pfam01434
1076934000062	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1076934000063	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1076934000064	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1076934000065	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1076934000066	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1076934000067	putative Zn2+ binding site [ion binding]; other site
1076934000068	putative DNA binding site [nucleotide binding]; other site
1076934000069	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1076934000070	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1076934000071	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1076934000072	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1076934000073	ABC-ATPase subunit  interface; other site
1076934000074	dimer interface [polypeptide binding]; other site
1076934000075	putative PBP binding regions; other site
1076934000076	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1076934000077	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1076934000078	Int/Topo IB signature motif; other site
1076934000079	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934000080	non-specific DNA binding site [nucleotide binding]; other site
1076934000081	salt bridge; other site
1076934000082	sequence-specific DNA binding site [nucleotide binding]; other site
1076934000083	Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545
1076934000084	Virulence-associated protein E; Region: VirE; pfam05272
1076934000085	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
1076934000086	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
1076934000087	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934000088	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934000089	Integrase core domain; Region: rve; pfam00665
1076934000090	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1076934000091	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1076934000092	active site
1076934000093	HIGH motif; other site
1076934000094	dimer interface [polypeptide binding]; other site
1076934000095	KMSKS motif; other site
1076934000096	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1076934000097	RNA binding surface [nucleotide binding]; other site
1076934000098	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1076934000099	Transglycosylase; Region: Transgly; pfam00912
1076934000100	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1076934000101	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1076934000102	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1076934000103	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1076934000104	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1076934000105	RPB12 interaction site [polypeptide binding]; other site
1076934000106	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1076934000107	RPB10 interaction site [polypeptide binding]; other site
1076934000108	RPB1 interaction site [polypeptide binding]; other site
1076934000109	RPB11 interaction site [polypeptide binding]; other site
1076934000110	RPB3 interaction site [polypeptide binding]; other site
1076934000111	RPB12 interaction site [polypeptide binding]; other site
1076934000112	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1076934000113	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1076934000114	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1076934000115	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1076934000116	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1076934000117	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1076934000118	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1076934000119	G-loop; other site
1076934000120	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1076934000121	DNA binding site [nucleotide binding]
1076934000122	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1076934000123	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
1076934000124	Type II/IV secretion system protein; Region: T2SE; pfam00437
1076934000125	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1076934000126	Walker A motif; other site
1076934000127	ATP binding site [chemical binding]; other site
1076934000128	Walker B motif; other site
1076934000129	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1076934000130	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1076934000131	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1076934000132	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1076934000133	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
1076934000134	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1076934000135	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1076934000136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934000137	S-adenosylmethionine binding site [chemical binding]; other site
1076934000138	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1076934000139	propionate/acetate kinase; Provisional; Region: PRK12379
1076934000140	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934000141	non-specific DNA binding site [nucleotide binding]; other site
1076934000142	salt bridge; other site
1076934000143	sequence-specific DNA binding site [nucleotide binding]; other site
1076934000144	CAAX protease self-immunity; Region: Abi; pfam02517
1076934000145	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1076934000146	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1076934000147	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1076934000148	glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107
1076934000149	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1076934000150	catalytic residues [active]
1076934000151	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1076934000152	putative tRNA-binding site [nucleotide binding]; other site
1076934000153	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1076934000154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934000155	S-adenosylmethionine binding site [chemical binding]; other site
1076934000156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1076934000157	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1076934000158	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1076934000159	dimer interface [polypeptide binding]; other site
1076934000160	ssDNA binding site [nucleotide binding]; other site
1076934000161	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1076934000162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1076934000163	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1076934000164	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1076934000165	Integrase core domain; Region: rve; pfam00665
1076934000166	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1076934000167	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1076934000168	zinc binding site [ion binding]; other site
1076934000169	putative ligand binding site [chemical binding]; other site
1076934000170	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1076934000171	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1076934000172	TM-ABC transporter signature motif; other site
1076934000173	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1076934000174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934000175	Walker A/P-loop; other site
1076934000176	ATP binding site [chemical binding]; other site
1076934000177	Q-loop/lid; other site
1076934000178	ABC transporter signature motif; other site
1076934000179	Walker B; other site
1076934000180	D-loop; other site
1076934000181	H-loop/switch region; other site
1076934000182	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1076934000183	oligomerisation interface [polypeptide binding]; other site
1076934000184	mobile loop; other site
1076934000185	roof hairpin; other site
1076934000186	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1076934000187	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1076934000188	ring oligomerisation interface [polypeptide binding]; other site
1076934000189	ATP/Mg binding site [chemical binding]; other site
1076934000190	stacking interactions; other site
1076934000191	hinge regions; other site
1076934000192	diaminopimelate decarboxylase; Region: PLN02537
1076934000193	Predicted membrane protein [Function unknown]; Region: COG4640
1076934000194	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1076934000195	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1076934000196	active site
1076934000197	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1076934000198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1076934000199	putative substrate translocation pore; other site
1076934000200	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1076934000201	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1076934000202	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1076934000203	Transglycosylase; Region: Transgly; pfam00912
1076934000204	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1076934000205	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1076934000206	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1076934000207	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1076934000208	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1076934000209	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1076934000210	putative homodimer interface [polypeptide binding]; other site
1076934000211	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1076934000212	heterodimer interface [polypeptide binding]; other site
1076934000213	homodimer interface [polypeptide binding]; other site
1076934000214	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1076934000215	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1076934000216	active site
1076934000217	nucleophile elbow; other site
1076934000218	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1076934000219	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1076934000220	HIGH motif; other site
1076934000221	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1076934000222	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1076934000223	active site
1076934000224	KMSKS motif; other site
1076934000225	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1076934000226	tRNA binding surface [nucleotide binding]; other site
1076934000227	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1076934000228	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1076934000229	active site
1076934000230	catalytic residues [active]
1076934000231	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1076934000232	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1076934000233	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1076934000234	recombination factor protein RarA; Reviewed; Region: PRK13342
1076934000235	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934000236	Walker A motif; other site
1076934000237	ATP binding site [chemical binding]; other site
1076934000238	Walker B motif; other site
1076934000239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1076934000240	arginine finger; other site
1076934000241	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1076934000242	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1076934000243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1076934000244	Coenzyme A binding pocket [chemical binding]; other site
1076934000245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1076934000246	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
1076934000247	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1076934000248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934000249	S-adenosylmethionine binding site [chemical binding]; other site
1076934000250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1076934000251	RNA methyltransferase, RsmE family; Region: TIGR00046
1076934000252	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1076934000253	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
1076934000254	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1076934000255	active site turn [active]
1076934000256	phosphorylation site [posttranslational modification]
1076934000257	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1076934000258	HPr interaction site; other site
1076934000259	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1076934000260	active site
1076934000261	phosphorylation site [posttranslational modification]
1076934000262	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
1076934000263	putative catalytic site [active]
1076934000264	putative metal binding site [ion binding]; other site
1076934000265	putative phosphate binding site [ion binding]; other site
1076934000266	DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207
1076934000267	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1076934000268	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1076934000269	putative oligomer interface [polypeptide binding]; other site
1076934000270	putative active site [active]
1076934000271	metal binding site [ion binding]; metal-binding site
1076934000272	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1076934000273	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1076934000274	DNA binding site [nucleotide binding]
1076934000275	domain linker motif; other site
1076934000276	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1076934000277	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1076934000278	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1076934000279	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1076934000280	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934000281	dimer interface [polypeptide binding]; other site
1076934000282	conserved gate region; other site
1076934000283	putative PBP binding loops; other site
1076934000284	ABC-ATPase subunit interface; other site
1076934000285	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1076934000286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934000287	dimer interface [polypeptide binding]; other site
1076934000288	conserved gate region; other site
1076934000289	putative PBP binding loops; other site
1076934000290	ABC-ATPase subunit interface; other site
1076934000291	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1076934000292	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1076934000293	Walker A/P-loop; other site
1076934000294	ATP binding site [chemical binding]; other site
1076934000295	Q-loop/lid; other site
1076934000296	ABC transporter signature motif; other site
1076934000297	Walker B; other site
1076934000298	D-loop; other site
1076934000299	H-loop/switch region; other site
1076934000300	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1076934000301	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1076934000302	substrate binding [chemical binding]; other site
1076934000303	active site
1076934000304	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1076934000305	flavoprotein NrdI; Provisional; Region: PRK02551
1076934000306	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
1076934000307	active site
1076934000308	P-loop; other site
1076934000309	phosphorylation site [posttranslational modification]
1076934000310	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1076934000311	methionine cluster; other site
1076934000312	active site
1076934000313	phosphorylation site [posttranslational modification]
1076934000314	metal binding site [ion binding]; metal-binding site
1076934000315	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1076934000316	beta-galactosidase; Region: BGL; TIGR03356
1076934000317	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1076934000318	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1076934000319	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1076934000320	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1076934000321	DNA-binding site [nucleotide binding]; DNA binding site
1076934000322	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1076934000323	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1076934000324	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1076934000325	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1076934000326	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1076934000327	DNA-binding site [nucleotide binding]; DNA binding site
1076934000328	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1076934000329	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1076934000330	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1076934000331	nucleotide binding site [chemical binding]; other site
1076934000332	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
1076934000333	active site
1076934000334	catalytic triad [active]
1076934000335	oxyanion hole [active]
1076934000336	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1076934000337	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1076934000338	Zn2+ binding site [ion binding]; other site
1076934000339	Mg2+ binding site [ion binding]; other site
1076934000340	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1076934000341	synthetase active site [active]
1076934000342	NTP binding site [chemical binding]; other site
1076934000343	metal binding site [ion binding]; metal-binding site
1076934000344	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1076934000345	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1076934000346	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1076934000347	putative active site [active]
1076934000348	dimerization interface [polypeptide binding]; other site
1076934000349	putative tRNAtyr binding site [nucleotide binding]; other site
1076934000350	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1076934000351	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1076934000352	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1076934000353	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1076934000354	Walker A/P-loop; other site
1076934000355	ATP binding site [chemical binding]; other site
1076934000356	Q-loop/lid; other site
1076934000357	ABC transporter signature motif; other site
1076934000358	Walker B; other site
1076934000359	D-loop; other site
1076934000360	H-loop/switch region; other site
1076934000361	TOBE domain; Region: TOBE_2; pfam08402
1076934000362	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1076934000363	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1076934000364	DNA-binding site [nucleotide binding]; DNA binding site
1076934000365	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1076934000366	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
1076934000367	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1076934000368	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1076934000369	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1076934000370	putative substrate binding site [chemical binding]; other site
1076934000371	putative ATP binding site [chemical binding]; other site
1076934000372	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1076934000373	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1076934000374	active site
1076934000375	phosphorylation site [posttranslational modification]
1076934000376	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414
1076934000377	active site
1076934000378	P-loop; other site
1076934000379	phosphorylation site [posttranslational modification]
1076934000380	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1076934000381	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
1076934000382	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1076934000383	active site
1076934000384	catalytic residues [active]
1076934000385	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1076934000386	CAT RNA binding domain; Region: CAT_RBD; smart01061
1076934000387	PRD domain; Region: PRD; pfam00874
1076934000388	PRD domain; Region: PRD; pfam00874
1076934000389	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1076934000390	beta-galactosidase; Region: BGL; TIGR03356
1076934000391	PRD domain; Region: PRD; pfam00874
1076934000392	PRD domain; Region: PRD; pfam00874
1076934000393	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1076934000394	methionine cluster; other site
1076934000395	active site
1076934000396	phosphorylation site [posttranslational modification]
1076934000397	metal binding site [ion binding]; metal-binding site
1076934000398	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
1076934000399	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1076934000400	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
1076934000401	active site
1076934000402	P-loop; other site
1076934000403	phosphorylation site [posttranslational modification]
1076934000404	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1076934000405	beta-galactosidase; Region: BGL; TIGR03356
1076934000406	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1076934000407	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1076934000408	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1076934000409	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1076934000410	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1076934000411	Melibiase; Region: Melibiase; pfam02065
1076934000412	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1076934000413	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1076934000414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934000415	dimer interface [polypeptide binding]; other site
1076934000416	conserved gate region; other site
1076934000417	putative PBP binding loops; other site
1076934000418	ABC-ATPase subunit interface; other site
1076934000419	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1076934000420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934000421	dimer interface [polypeptide binding]; other site
1076934000422	conserved gate region; other site
1076934000423	putative PBP binding loops; other site
1076934000424	ABC-ATPase subunit interface; other site
1076934000425	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
1076934000426	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
1076934000427	active site
1076934000428	homodimer interface [polypeptide binding]; other site
1076934000429	catalytic site [active]
1076934000430	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1076934000431	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1076934000432	Ca binding site [ion binding]; other site
1076934000433	active site
1076934000434	catalytic site [active]
1076934000435	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
1076934000436	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1076934000437	DNA binding site [nucleotide binding]
1076934000438	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1076934000439	putative dimerization interface [polypeptide binding]; other site
1076934000440	putative ligand binding site [chemical binding]; other site
1076934000441	galactokinase; Provisional; Region: PRK05322
1076934000442	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1076934000443	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1076934000444	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1076934000445	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
1076934000446	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1076934000447	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1076934000448	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1076934000449	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1076934000450	NAD binding site [chemical binding]; other site
1076934000451	homodimer interface [polypeptide binding]; other site
1076934000452	active site
1076934000453	substrate binding site [chemical binding]; other site
1076934000454	Preprotein translocase subunit; Region: YajC; cl00806
1076934000455	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1076934000456	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1076934000457	catalytic residue [active]
1076934000458	putative FPP diphosphate  binding site; other site
1076934000459	putative FPP binding hydrophobic cleft; other site
1076934000460	dimer interface [polypeptide binding]; other site
1076934000461	putative IPP diphosphate binding site; other site
1076934000462	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1076934000463	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1076934000464	RIP metalloprotease RseP; Region: TIGR00054
1076934000465	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1076934000466	active site
1076934000467	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1076934000468	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1076934000469	protein binding site [polypeptide binding]; other site
1076934000470	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1076934000471	putative substrate binding region [chemical binding]; other site
1076934000472	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1076934000473	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1076934000474	motif 1; other site
1076934000475	dimer interface [polypeptide binding]; other site
1076934000476	active site
1076934000477	motif 2; other site
1076934000478	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1076934000479	putative deacylase active site [active]
1076934000480	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1076934000481	active site
1076934000482	motif 3; other site
1076934000483	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1076934000484	anticodon binding site; other site
1076934000485	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1076934000486	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1076934000487	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1076934000488	generic binding surface II; other site
1076934000489	generic binding surface I; other site
1076934000490	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1076934000491	active site
1076934000492	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1076934000493	active site
1076934000494	catalytic site [active]
1076934000495	substrate binding site [chemical binding]; other site
1076934000496	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1076934000497	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1076934000498	MarR family; Region: MarR; pfam01047
1076934000499	Predicted flavoprotein [General function prediction only]; Region: COG0431
1076934000500	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1076934000501	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1076934000502	active site
1076934000503	catalytic residues [active]
1076934000504	metal binding site [ion binding]; metal-binding site
1076934000505	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1076934000506	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1076934000507	ligand binding site [chemical binding]; other site
1076934000508	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1076934000509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1076934000510	putative substrate translocation pore; other site
1076934000511	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1076934000512	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1076934000513	16S/18S rRNA binding site [nucleotide binding]; other site
1076934000514	S13e-L30e interaction site [polypeptide binding]; other site
1076934000515	25S rRNA binding site [nucleotide binding]; other site
1076934000516	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1076934000517	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1076934000518	putative catalytic cysteine [active]
1076934000519	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1076934000520	putative active site [active]
1076934000521	metal binding site [ion binding]; metal-binding site
1076934000522	Predicted membrane protein [Function unknown]; Region: COG2261
1076934000523	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1076934000524	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1076934000525	RNase E interface [polypeptide binding]; other site
1076934000526	trimer interface [polypeptide binding]; other site
1076934000527	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1076934000528	RNase E interface [polypeptide binding]; other site
1076934000529	trimer interface [polypeptide binding]; other site
1076934000530	active site
1076934000531	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1076934000532	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1076934000533	RNA binding site [nucleotide binding]; other site
1076934000534	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1076934000535	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1076934000536	trimer interface [polypeptide binding]; other site
1076934000537	active site
1076934000538	substrate binding site [chemical binding]; other site
1076934000539	CoA binding site [chemical binding]; other site
1076934000540	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1076934000541	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1076934000542	active site
1076934000543	HIGH motif; other site
1076934000544	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1076934000545	KMSKS motif; other site
1076934000546	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1076934000547	tRNA binding surface [nucleotide binding]; other site
1076934000548	anticodon binding site; other site
1076934000549	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1076934000550	active site
1076934000551	metal binding site [ion binding]; metal-binding site
1076934000552	dimerization interface [polypeptide binding]; other site
1076934000553	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1076934000554	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1076934000555	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1076934000556	YacP-like NYN domain; Region: NYN_YacP; cl01491
1076934000557	EDD domain protein, DegV family; Region: DegV; TIGR00762
1076934000558	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1076934000559	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1076934000560	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1076934000561	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1076934000562	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1076934000563	23S rRNA interface [nucleotide binding]; other site
1076934000564	L3 interface [polypeptide binding]; other site
1076934000565	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1076934000566	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1076934000567	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1076934000568	Int/Topo IB signature motif; other site
1076934000569	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934000570	non-specific DNA binding site [nucleotide binding]; other site
1076934000571	salt bridge; other site
1076934000572	sequence-specific DNA binding site [nucleotide binding]; other site
1076934000573	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1076934000574	YcaO-like family; Region: YcaO; pfam02624
1076934000575	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1076934000576	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1076934000577	NADPH bind site [chemical binding]; other site
1076934000578	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1076934000579	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1076934000580	Walker A/P-loop; other site
1076934000581	ATP binding site [chemical binding]; other site
1076934000582	Q-loop/lid; other site
1076934000583	ABC transporter signature motif; other site
1076934000584	Walker B; other site
1076934000585	D-loop; other site
1076934000586	H-loop/switch region; other site
1076934000587	LytTr DNA-binding domain; Region: LytTR; smart00850
1076934000588	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1076934000589	active site
1076934000590	DNA binding site [nucleotide binding]
1076934000591	Int/Topo IB signature motif; other site
1076934000592	Helix-turn-helix domain; Region: HTH_17; cl17695
1076934000593	Plasmid replication protein; Region: Rep_2; pfam01719
1076934000594	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1076934000595	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1076934000596	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1076934000597	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
1076934000598	DNA methylase; Region: N6_N4_Mtase; pfam01555
1076934000599	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1076934000600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934000601	S-adenosylmethionine binding site [chemical binding]; other site
1076934000602	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1076934000603	DNA binding site [nucleotide binding]
1076934000604	active site
1076934000605	Int/Topo IB signature motif; other site
1076934000606	catalytic residues [active]
1076934000607	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
1076934000608	homodimer interface [polypeptide binding]; other site
1076934000609	putative active site [active]
1076934000610	catalytic site [active]
1076934000611	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1076934000612	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1076934000613	cofactor binding site; other site
1076934000614	DNA binding site [nucleotide binding]
1076934000615	substrate interaction site [chemical binding]; other site
1076934000616	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1076934000617	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1076934000618	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1076934000619	cofactor binding site; other site
1076934000620	DNA binding site [nucleotide binding]
1076934000621	substrate interaction site [chemical binding]; other site
1076934000622	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1076934000623	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1076934000624	sequence-specific DNA binding site [nucleotide binding]; other site
1076934000625	salt bridge; other site
1076934000626	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1076934000627	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1076934000628	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1076934000629	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1076934000630	catalytic core [active]
1076934000631	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1076934000632	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1076934000633	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1076934000634	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1076934000635	GrpE; Region: GrpE; pfam01025
1076934000636	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1076934000637	dimer interface [polypeptide binding]; other site
1076934000638	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1076934000639	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1076934000640	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1076934000641	nucleotide binding site [chemical binding]; other site
1076934000642	NEF interaction site [polypeptide binding]; other site
1076934000643	SBD interface [polypeptide binding]; other site
1076934000644	chaperone protein DnaJ; Provisional; Region: PRK14276
1076934000645	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1076934000646	HSP70 interaction site [polypeptide binding]; other site
1076934000647	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1076934000648	substrate binding site [polypeptide binding]; other site
1076934000649	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1076934000650	Zn binding sites [ion binding]; other site
1076934000651	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1076934000652	substrate binding site [polypeptide binding]; other site
1076934000653	dimer interface [polypeptide binding]; other site
1076934000654	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1076934000655	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1076934000656	dimerization interface 3.5A [polypeptide binding]; other site
1076934000657	active site
1076934000658	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1076934000659	dimer interface [polypeptide binding]; other site
1076934000660	substrate binding site [chemical binding]; other site
1076934000661	ATP binding site [chemical binding]; other site
1076934000662	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1076934000663	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1076934000664	hypothetical protein; Provisional; Region: PRK13690
1076934000665	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1076934000666	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1076934000667	trigger factor; Provisional; Region: tig; PRK01490
1076934000668	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1076934000669	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1076934000670	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1076934000671	CTP synthetase; Validated; Region: pyrG; PRK05380
1076934000672	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1076934000673	Catalytic site [active]
1076934000674	active site
1076934000675	UTP binding site [chemical binding]; other site
1076934000676	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1076934000677	active site
1076934000678	putative oxyanion hole; other site
1076934000679	catalytic triad [active]
1076934000680	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1076934000681	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1076934000682	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1076934000683	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1076934000684	intersubunit interface [polypeptide binding]; other site
1076934000685	active site
1076934000686	zinc binding site [ion binding]; other site
1076934000687	Na+ binding site [ion binding]; other site
1076934000688	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934000689	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934000690	Integrase core domain; Region: rve; pfam00665
1076934000691	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1076934000692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1076934000693	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1076934000694	DAK2 domain; Region: Dak2; pfam02734
1076934000695	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1076934000696	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1076934000697	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1076934000698	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1076934000699	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1076934000700	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1076934000701	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1076934000702	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1076934000703	TPP-binding site [chemical binding]; other site
1076934000704	dimer interface [polypeptide binding]; other site
1076934000705	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1076934000706	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1076934000707	putative valine binding site [chemical binding]; other site
1076934000708	dimer interface [polypeptide binding]; other site
1076934000709	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1076934000710	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1076934000711	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1076934000712	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1076934000713	threonine dehydratase; Validated; Region: PRK08639
1076934000714	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1076934000715	tetramer interface [polypeptide binding]; other site
1076934000716	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934000717	catalytic residue [active]
1076934000718	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
1076934000719	HflK protein; Region: hflK; TIGR01933
1076934000720	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
1076934000721	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1076934000722	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1076934000723	Walker A/P-loop; other site
1076934000724	ATP binding site [chemical binding]; other site
1076934000725	Q-loop/lid; other site
1076934000726	ABC transporter signature motif; other site
1076934000727	Walker B; other site
1076934000728	D-loop; other site
1076934000729	H-loop/switch region; other site
1076934000730	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934000731	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934000732	substrate binding pocket [chemical binding]; other site
1076934000733	membrane-bound complex binding site; other site
1076934000734	hinge residues; other site
1076934000735	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1076934000736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934000737	dimer interface [polypeptide binding]; other site
1076934000738	conserved gate region; other site
1076934000739	putative PBP binding loops; other site
1076934000740	ABC-ATPase subunit interface; other site
1076934000741	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
1076934000742	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1076934000743	adaptor protein; Provisional; Region: PRK02315
1076934000744	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1076934000745	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1076934000746	Mg++ binding site [ion binding]; other site
1076934000747	putative catalytic motif [active]
1076934000748	substrate binding site [chemical binding]; other site
1076934000749	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1076934000750	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1076934000751	Walker A/P-loop; other site
1076934000752	ATP binding site [chemical binding]; other site
1076934000753	Q-loop/lid; other site
1076934000754	ABC transporter signature motif; other site
1076934000755	Walker B; other site
1076934000756	D-loop; other site
1076934000757	H-loop/switch region; other site
1076934000758	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1076934000759	FeS assembly protein SufD; Region: sufD; TIGR01981
1076934000760	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1076934000761	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1076934000762	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1076934000763	catalytic residue [active]
1076934000764	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1076934000765	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1076934000766	trimerization site [polypeptide binding]; other site
1076934000767	active site
1076934000768	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1076934000769	FeS assembly protein SufB; Region: sufB; TIGR01980
1076934000770	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1076934000771	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1076934000772	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1076934000773	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1076934000774	peptide binding site [polypeptide binding]; other site
1076934000775	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1076934000776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934000777	dimer interface [polypeptide binding]; other site
1076934000778	conserved gate region; other site
1076934000779	putative PBP binding loops; other site
1076934000780	ABC-ATPase subunit interface; other site
1076934000781	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1076934000782	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1076934000783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934000784	dimer interface [polypeptide binding]; other site
1076934000785	conserved gate region; other site
1076934000786	putative PBP binding loops; other site
1076934000787	ABC-ATPase subunit interface; other site
1076934000788	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1076934000789	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1076934000790	Walker A/P-loop; other site
1076934000791	ATP binding site [chemical binding]; other site
1076934000792	Q-loop/lid; other site
1076934000793	ABC transporter signature motif; other site
1076934000794	Walker B; other site
1076934000795	D-loop; other site
1076934000796	H-loop/switch region; other site
1076934000797	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1076934000798	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1076934000799	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1076934000800	Walker A/P-loop; other site
1076934000801	ATP binding site [chemical binding]; other site
1076934000802	Q-loop/lid; other site
1076934000803	ABC transporter signature motif; other site
1076934000804	Walker B; other site
1076934000805	D-loop; other site
1076934000806	H-loop/switch region; other site
1076934000807	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1076934000808	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934000809	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934000810	Integrase core domain; Region: rve; pfam00665
1076934000811	rod shape-determining protein MreC; Provisional; Region: PRK13922
1076934000812	rod shape-determining protein MreC; Region: MreC; pfam04085
1076934000813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1076934000814	Surface antigen [General function prediction only]; Region: COG3942
1076934000815	CHAP domain; Region: CHAP; pfam05257
1076934000816	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
1076934000817	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1076934000818	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934000819	active site
1076934000820	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1076934000821	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1076934000822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934000823	homodimer interface [polypeptide binding]; other site
1076934000824	catalytic residue [active]
1076934000825	Recombination protein O N terminal; Region: RecO_N; pfam11967
1076934000826	DNA repair protein RecO; Region: reco; TIGR00613
1076934000827	Recombination protein O C terminal; Region: RecO_C; pfam02565
1076934000828	putative phosphate acyltransferase; Provisional; Region: PRK05331
1076934000829	acyl carrier protein; Provisional; Region: PRK12449
1076934000830	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1076934000831	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1076934000832	ATP binding site [chemical binding]; other site
1076934000833	active site
1076934000834	substrate binding site [chemical binding]; other site
1076934000835	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
1076934000836	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1076934000837	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1076934000838	dimerization interface [polypeptide binding]; other site
1076934000839	ATP binding site [chemical binding]; other site
1076934000840	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1076934000841	dimerization interface [polypeptide binding]; other site
1076934000842	ATP binding site [chemical binding]; other site
1076934000843	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1076934000844	putative active site [active]
1076934000845	catalytic triad [active]
1076934000846	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1076934000847	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1076934000848	active site
1076934000849	tetramer interface [polypeptide binding]; other site
1076934000850	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934000851	active site
1076934000852	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1076934000853	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1076934000854	purine monophosphate binding site [chemical binding]; other site
1076934000855	dimer interface [polypeptide binding]; other site
1076934000856	putative catalytic residues [active]
1076934000857	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1076934000858	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1076934000859	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1076934000860	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1076934000861	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1076934000862	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1076934000863	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1076934000864	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1076934000865	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1076934000866	ATP-grasp domain; Region: ATP-grasp; pfam02222
1076934000867	adenylosuccinate lyase; Provisional; Region: PRK07492
1076934000868	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1076934000869	tetramer interface [polypeptide binding]; other site
1076934000870	active site
1076934000871	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1076934000872	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934000873	non-specific DNA binding site [nucleotide binding]; other site
1076934000874	salt bridge; other site
1076934000875	sequence-specific DNA binding site [nucleotide binding]; other site
1076934000876	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1076934000877	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934000878	Walker A motif; other site
1076934000879	ATP binding site [chemical binding]; other site
1076934000880	Walker B motif; other site
1076934000881	arginine finger; other site
1076934000882	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1076934000883	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1076934000884	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1076934000885	active site
1076934000886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1076934000887	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1076934000888	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1076934000889	active site
1076934000890	catalytic triad [active]
1076934000891	oxyanion hole [active]
1076934000892	putative transposase OrfB; Reviewed; Region: PHA02517
1076934000893	HTH-like domain; Region: HTH_21; pfam13276
1076934000894	Integrase core domain; Region: rve; pfam00665
1076934000895	Integrase core domain; Region: rve_2; pfam13333
1076934000896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1076934000897	Homeodomain-like domain; Region: HTH_23; cl17451
1076934000898	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1076934000899	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1076934000900	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934000901	catalytic residue [active]
1076934000902	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1076934000903	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1076934000904	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1076934000905	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1076934000906	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1076934000907	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1076934000908	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1076934000909	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1076934000910	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1076934000911	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1076934000912	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1076934000913	putative translocon binding site; other site
1076934000914	protein-rRNA interface [nucleotide binding]; other site
1076934000915	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1076934000916	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1076934000917	G-X-X-G motif; other site
1076934000918	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1076934000919	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1076934000920	23S rRNA interface [nucleotide binding]; other site
1076934000921	5S rRNA interface [nucleotide binding]; other site
1076934000922	putative antibiotic binding site [chemical binding]; other site
1076934000923	L25 interface [polypeptide binding]; other site
1076934000924	L27 interface [polypeptide binding]; other site
1076934000925	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1076934000926	23S rRNA interface [nucleotide binding]; other site
1076934000927	putative translocon interaction site; other site
1076934000928	signal recognition particle (SRP54) interaction site; other site
1076934000929	L23 interface [polypeptide binding]; other site
1076934000930	trigger factor interaction site; other site
1076934000931	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1076934000932	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1076934000933	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1076934000934	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1076934000935	RNA binding site [nucleotide binding]; other site
1076934000936	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1076934000937	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1076934000938	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1076934000939	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1076934000940	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1076934000941	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1076934000942	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1076934000943	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1076934000944	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1076934000945	5S rRNA interface [nucleotide binding]; other site
1076934000946	L27 interface [polypeptide binding]; other site
1076934000947	23S rRNA interface [nucleotide binding]; other site
1076934000948	L5 interface [polypeptide binding]; other site
1076934000949	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1076934000950	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1076934000951	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1076934000952	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1076934000953	23S rRNA binding site [nucleotide binding]; other site
1076934000954	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1076934000955	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1076934000956	SecY translocase; Region: SecY; pfam00344
1076934000957	adenylate kinase; Reviewed; Region: adk; PRK00279
1076934000958	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1076934000959	AMP-binding site [chemical binding]; other site
1076934000960	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1076934000961	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1076934000962	rRNA binding site [nucleotide binding]; other site
1076934000963	predicted 30S ribosome binding site; other site
1076934000964	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
1076934000965	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1076934000966	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1076934000967	30S ribosomal protein S11; Validated; Region: PRK05309
1076934000968	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1076934000969	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1076934000970	alphaNTD homodimer interface [polypeptide binding]; other site
1076934000971	alphaNTD - beta interaction site [polypeptide binding]; other site
1076934000972	alphaNTD - beta' interaction site [polypeptide binding]; other site
1076934000973	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1076934000974	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1076934000975	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934000976	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934000977	Integrase core domain; Region: rve; pfam00665
1076934000978	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1076934000979	aspartate kinase; Reviewed; Region: PRK09034
1076934000980	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1076934000981	putative catalytic residues [active]
1076934000982	putative nucleotide binding site [chemical binding]; other site
1076934000983	putative aspartate binding site [chemical binding]; other site
1076934000984	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1076934000985	allosteric regulatory residue; other site
1076934000986	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1076934000987	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1076934000988	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934000989	motif II; other site
1076934000990	enoyl-CoA hydratase; Provisional; Region: PRK07260
1076934000991	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1076934000992	substrate binding site [chemical binding]; other site
1076934000993	oxyanion hole (OAH) forming residues; other site
1076934000994	trimer interface [polypeptide binding]; other site
1076934000995	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1076934000996	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1076934000997	putative Zn2+ binding site [ion binding]; other site
1076934000998	putative DNA binding site [nucleotide binding]; other site
1076934000999	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1076934001000	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1076934001001	dimer interface [polypeptide binding]; other site
1076934001002	active site
1076934001003	CoA binding pocket [chemical binding]; other site
1076934001004	acyl carrier protein; Provisional; Region: acpP; PRK00982
1076934001005	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1076934001006	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1076934001007	FMN binding site [chemical binding]; other site
1076934001008	substrate binding site [chemical binding]; other site
1076934001009	putative catalytic residue [active]
1076934001010	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1076934001011	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1076934001012	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1076934001013	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1076934001014	NAD(P) binding site [chemical binding]; other site
1076934001015	homotetramer interface [polypeptide binding]; other site
1076934001016	homodimer interface [polypeptide binding]; other site
1076934001017	active site
1076934001018	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1076934001019	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1076934001020	dimer interface [polypeptide binding]; other site
1076934001021	active site
1076934001022	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1076934001023	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1076934001024	carboxyltransferase (CT) interaction site; other site
1076934001025	biotinylation site [posttranslational modification]; other site
1076934001026	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1076934001027	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1076934001028	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1076934001029	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1076934001030	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1076934001031	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1076934001032	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1076934001033	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
1076934001034	seryl-tRNA synthetase; Provisional; Region: PRK05431
1076934001035	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1076934001036	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1076934001037	dimer interface [polypeptide binding]; other site
1076934001038	active site
1076934001039	motif 1; other site
1076934001040	motif 2; other site
1076934001041	motif 3; other site
1076934001042	Domain of unknown function (DUF956); Region: DUF956; pfam06115
1076934001043	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1076934001044	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1076934001045	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1076934001046	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1076934001047	active pocket/dimerization site; other site
1076934001048	active site
1076934001049	phosphorylation site [posttranslational modification]
1076934001050	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1076934001051	active site
1076934001052	phosphorylation site [posttranslational modification]
1076934001053	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1076934001054	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934001055	active site
1076934001056	motif I; other site
1076934001057	motif II; other site
1076934001058	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
1076934001059	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1076934001060	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1076934001061	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1076934001062	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1076934001063	Coenzyme A binding pocket [chemical binding]; other site
1076934001064	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1076934001065	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1076934001066	HIT family signature motif; other site
1076934001067	catalytic residue [active]
1076934001068	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1076934001069	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1076934001070	Walker A/P-loop; other site
1076934001071	ATP binding site [chemical binding]; other site
1076934001072	Q-loop/lid; other site
1076934001073	ABC transporter signature motif; other site
1076934001074	Walker B; other site
1076934001075	D-loop; other site
1076934001076	H-loop/switch region; other site
1076934001077	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
1076934001078	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
1076934001079	Phosphotransferase enzyme family; Region: APH; pfam01636
1076934001080	substrate binding site [chemical binding]; other site
1076934001081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934001082	S-adenosylmethionine binding site [chemical binding]; other site
1076934001083	PAS fold; Region: PAS_4; pfam08448
1076934001084	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1076934001085	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1076934001086	metal binding site [ion binding]; metal-binding site
1076934001087	active site
1076934001088	I-site; other site
1076934001089	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
1076934001090	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1076934001091	Ligand binding site; other site
1076934001092	Putative Catalytic site; other site
1076934001093	DXD motif; other site
1076934001094	GtrA-like protein; Region: GtrA; pfam04138
1076934001095	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1076934001096	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1076934001097	DXD motif; other site
1076934001098	PilZ domain; Region: PilZ; pfam07238
1076934001099	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1076934001100	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1076934001101	putative oligomer interface [polypeptide binding]; other site
1076934001102	putative RNA binding site [nucleotide binding]; other site
1076934001103	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1076934001104	NusA N-terminal domain; Region: NusA_N; pfam08529
1076934001105	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1076934001106	RNA binding site [nucleotide binding]; other site
1076934001107	homodimer interface [polypeptide binding]; other site
1076934001108	NusA-like KH domain; Region: KH_5; pfam13184
1076934001109	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1076934001110	G-X-X-G motif; other site
1076934001111	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1076934001112	putative RNA binding cleft [nucleotide binding]; other site
1076934001113	hypothetical protein; Provisional; Region: PRK07283
1076934001114	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1076934001115	translation initiation factor IF-2; Region: IF-2; TIGR00487
1076934001116	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1076934001117	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1076934001118	G1 box; other site
1076934001119	putative GEF interaction site [polypeptide binding]; other site
1076934001120	GTP/Mg2+ binding site [chemical binding]; other site
1076934001121	Switch I region; other site
1076934001122	G2 box; other site
1076934001123	G3 box; other site
1076934001124	Switch II region; other site
1076934001125	G4 box; other site
1076934001126	G5 box; other site
1076934001127	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1076934001128	Translation-initiation factor 2; Region: IF-2; pfam11987
1076934001129	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1076934001130	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1076934001131	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1076934001132	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1076934001133	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1076934001134	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1076934001135	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1076934001136	metal-binding site [ion binding]
1076934001137	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1076934001138	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934001139	motif II; other site
1076934001140	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1076934001141	metal-binding site [ion binding]
1076934001142	Predicted membrane protein [Function unknown]; Region: COG2860
1076934001143	UPF0126 domain; Region: UPF0126; pfam03458
1076934001144	UPF0126 domain; Region: UPF0126; pfam03458
1076934001145	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934001146	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1076934001147	active site
1076934001148	motif I; other site
1076934001149	motif II; other site
1076934001150	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934001151	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1076934001152	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1076934001153	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
1076934001154	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1076934001155	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934001156	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934001157	Integrase core domain; Region: rve; pfam00665
1076934001158	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1076934001159	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1076934001160	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1076934001161	PhoU domain; Region: PhoU; pfam01895
1076934001162	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1076934001163	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1076934001164	active site
1076934001165	dimer interface [polypeptide binding]; other site
1076934001166	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1076934001167	dimer interface [polypeptide binding]; other site
1076934001168	motif 1; other site
1076934001169	active site
1076934001170	motif 2; other site
1076934001171	motif 3; other site
1076934001172	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1076934001173	DALR anticodon binding domain; Region: DALR_1; pfam05746
1076934001174	hypothetical protein; Provisional; Region: PRK02539
1076934001175	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1076934001176	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1076934001177	TPP-binding site [chemical binding]; other site
1076934001178	dimer interface [polypeptide binding]; other site
1076934001179	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1076934001180	PYR/PP interface [polypeptide binding]; other site
1076934001181	dimer interface [polypeptide binding]; other site
1076934001182	TPP binding site [chemical binding]; other site
1076934001183	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1076934001184	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1076934001185	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1076934001186	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1076934001187	Walker A/P-loop; other site
1076934001188	ATP binding site [chemical binding]; other site
1076934001189	Q-loop/lid; other site
1076934001190	ABC transporter signature motif; other site
1076934001191	Walker B; other site
1076934001192	D-loop; other site
1076934001193	H-loop/switch region; other site
1076934001194	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
1076934001195	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1076934001196	nucleotide binding site [chemical binding]; other site
1076934001197	homotetrameric interface [polypeptide binding]; other site
1076934001198	putative phosphate binding site [ion binding]; other site
1076934001199	putative allosteric binding site; other site
1076934001200	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1076934001201	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1076934001202	putative catalytic cysteine [active]
1076934001203	MraW methylase family; Region: Methyltransf_5; pfam01795
1076934001204	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1076934001205	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
1076934001206	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1076934001207	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1076934001208	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1076934001209	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
1076934001210	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1076934001211	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1076934001212	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1076934001213	Mg++ binding site [ion binding]; other site
1076934001214	putative catalytic motif [active]
1076934001215	putative substrate binding site [chemical binding]; other site
1076934001216	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1076934001217	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1076934001218	ATP binding site [chemical binding]; other site
1076934001219	Mg++ binding site [ion binding]; other site
1076934001220	motif III; other site
1076934001221	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934001222	nucleotide binding region [chemical binding]; other site
1076934001223	ATP-binding site [chemical binding]; other site
1076934001224	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934001225	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934001226	substrate binding pocket [chemical binding]; other site
1076934001227	membrane-bound complex binding site; other site
1076934001228	hinge residues; other site
1076934001229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934001230	dimer interface [polypeptide binding]; other site
1076934001231	conserved gate region; other site
1076934001232	putative PBP binding loops; other site
1076934001233	ABC-ATPase subunit interface; other site
1076934001234	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1076934001235	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1076934001236	Walker A/P-loop; other site
1076934001237	ATP binding site [chemical binding]; other site
1076934001238	Q-loop/lid; other site
1076934001239	ABC transporter signature motif; other site
1076934001240	Walker B; other site
1076934001241	D-loop; other site
1076934001242	H-loop/switch region; other site
1076934001243	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
1076934001244	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1076934001245	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1076934001246	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1076934001247	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1076934001248	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1076934001249	active site
1076934001250	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1076934001251	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1076934001252	homodimer interface [polypeptide binding]; other site
1076934001253	NAD binding pocket [chemical binding]; other site
1076934001254	ATP binding pocket [chemical binding]; other site
1076934001255	Mg binding site [ion binding]; other site
1076934001256	active-site loop [active]
1076934001257	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1076934001258	trimer interface [polypeptide binding]; other site
1076934001259	active site
1076934001260	G bulge; other site
1076934001261	Transglycosylase; Region: Transgly; pfam00912
1076934001262	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1076934001263	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1076934001264	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1076934001265	hypothetical protein; Provisional; Region: PRK13660
1076934001266	cell division protein GpsB; Provisional; Region: PRK14127
1076934001267	DivIVA domain; Region: DivI1A_domain; TIGR03544
1076934001268	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1076934001269	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1076934001270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1076934001271	acetoin reductase; Validated; Region: PRK08643
1076934001272	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1076934001273	NAD binding site [chemical binding]; other site
1076934001274	homotetramer interface [polypeptide binding]; other site
1076934001275	homodimer interface [polypeptide binding]; other site
1076934001276	active site
1076934001277	substrate binding site [chemical binding]; other site
1076934001278	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1076934001279	hypothetical protein; Provisional; Region: PRK00106
1076934001280	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1076934001281	Zn2+ binding site [ion binding]; other site
1076934001282	Mg2+ binding site [ion binding]; other site
1076934001283	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1076934001284	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1076934001285	catalytic site [active]
1076934001286	G-X2-G-X-G-K; other site
1076934001287	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1076934001288	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1076934001289	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1076934001290	ATP binding site [chemical binding]; other site
1076934001291	putative Mg++ binding site [ion binding]; other site
1076934001292	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934001293	ATP-binding site [chemical binding]; other site
1076934001294	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1076934001295	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1076934001296	putative active site [active]
1076934001297	substrate binding site [chemical binding]; other site
1076934001298	putative cosubstrate binding site; other site
1076934001299	catalytic site [active]
1076934001300	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1076934001301	substrate binding site [chemical binding]; other site
1076934001302	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1076934001303	NusB family; Region: NusB; pfam01029
1076934001304	putative RNA binding site [nucleotide binding]; other site
1076934001305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934001306	S-adenosylmethionine binding site [chemical binding]; other site
1076934001307	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1076934001308	active site
1076934001309	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1076934001310	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1076934001311	active site
1076934001312	ATP binding site [chemical binding]; other site
1076934001313	substrate binding site [chemical binding]; other site
1076934001314	activation loop (A-loop); other site
1076934001315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1076934001316	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1076934001317	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1076934001318	PASTA domain; Region: PASTA; pfam03793
1076934001319	Predicted membrane protein [Function unknown]; Region: COG4758
1076934001320	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1076934001321	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1076934001322	Histidine kinase; Region: HisKA_3; pfam07730
1076934001323	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934001324	ATP binding site [chemical binding]; other site
1076934001325	Mg2+ binding site [ion binding]; other site
1076934001326	G-X-G motif; other site
1076934001327	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1076934001328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934001329	active site
1076934001330	phosphorylation site [posttranslational modification]
1076934001331	intermolecular recognition site; other site
1076934001332	dimerization interface [polypeptide binding]; other site
1076934001333	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1076934001334	DNA binding residues [nucleotide binding]
1076934001335	dimerization interface [polypeptide binding]; other site
1076934001336	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934001337	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1076934001338	active site
1076934001339	motif I; other site
1076934001340	motif II; other site
1076934001341	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1076934001342	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1076934001343	active site
1076934001344	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
1076934001345	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
1076934001346	RNA binding site [nucleotide binding]; other site
1076934001347	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1076934001348	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1076934001349	dimer interface [polypeptide binding]; other site
1076934001350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934001351	catalytic residue [active]
1076934001352	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1076934001353	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1076934001354	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1076934001355	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1076934001356	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1076934001357	ATP binding site [chemical binding]; other site
1076934001358	putative Mg++ binding site [ion binding]; other site
1076934001359	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934001360	nucleotide binding region [chemical binding]; other site
1076934001361	ATP-binding site [chemical binding]; other site
1076934001362	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1076934001363	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934001364	active site
1076934001365	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1076934001366	30S subunit binding site; other site
1076934001367	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
1076934001368	hypothetical protein; Provisional; Region: PRK13662
1076934001369	recombination regulator RecX; Provisional; Region: recX; PRK14135
1076934001370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1076934001371	binding surface
1076934001372	TPR motif; other site
1076934001373	TRAM domain; Region: TRAM; pfam01938
1076934001374	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1076934001375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934001376	S-adenosylmethionine binding site [chemical binding]; other site
1076934001377	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1076934001378	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1076934001379	Coenzyme A binding pocket [chemical binding]; other site
1076934001380	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
1076934001381	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1076934001382	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1076934001383	Substrate-binding site [chemical binding]; other site
1076934001384	Substrate specificity [chemical binding]; other site
1076934001385	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1076934001386	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
1076934001387	hypothetical protein; Provisional; Region: PRK07758
1076934001388	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1076934001389	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1076934001390	active site
1076934001391	HIGH motif; other site
1076934001392	nucleotide binding site [chemical binding]; other site
1076934001393	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1076934001394	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1076934001395	active site
1076934001396	KMSKS motif; other site
1076934001397	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1076934001398	tRNA binding surface [nucleotide binding]; other site
1076934001399	anticodon binding site; other site
1076934001400	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1076934001401	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1076934001402	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1076934001403	myosin-cross-reactive antigen; Provisional; Region: PRK13977
1076934001404	HTH-like domain; Region: HTH_21; pfam13276
1076934001405	Integrase core domain; Region: rve; pfam00665
1076934001406	Protein of unknown function (DUF419); Region: DUF419; cl15265
1076934001407	Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502
1076934001408	motif 1; other site
1076934001409	dimer interface [polypeptide binding]; other site
1076934001410	active site
1076934001411	motif 2; other site
1076934001412	motif 3; other site
1076934001413	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1076934001414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934001415	S-adenosylmethionine binding site [chemical binding]; other site
1076934001416	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1076934001417	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1076934001418	active site
1076934001419	(T/H)XGH motif; other site
1076934001420	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1076934001421	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1076934001422	protein binding site [polypeptide binding]; other site
1076934001423	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1076934001424	Protein of unknown function (DUF3923); Region: DUF3923; pfam13061
1076934001425	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1076934001426	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1076934001427	active site
1076934001428	metal binding site [ion binding]; metal-binding site
1076934001429	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1076934001430	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
1076934001431	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1076934001432	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1076934001433	FeS/SAM binding site; other site
1076934001434	VanZ like family; Region: VanZ; pfam04892
1076934001435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934001436	D-loop; other site
1076934001437	H-loop/switch region; other site
1076934001438	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1076934001439	active site
1076934001440	ribulose/triose binding site [chemical binding]; other site
1076934001441	phosphate binding site [ion binding]; other site
1076934001442	substrate (anthranilate) binding pocket [chemical binding]; other site
1076934001443	product (indole) binding pocket [chemical binding]; other site
1076934001444	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1076934001445	active site
1076934001446	manganese transport protein MntH; Reviewed; Region: PRK00701
1076934001447	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1076934001448	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1076934001449	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1076934001450	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1076934001451	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1076934001452	dimerization interface [polypeptide binding]; other site
1076934001453	DPS ferroxidase diiron center [ion binding]; other site
1076934001454	ion pore; other site
1076934001455	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
1076934001456	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1076934001457	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1076934001458	nucleotide binding site [chemical binding]; other site
1076934001459	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1076934001460	active site residue [active]
1076934001461	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1076934001462	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1076934001463	G1 box; other site
1076934001464	putative GEF interaction site [polypeptide binding]; other site
1076934001465	GTP/Mg2+ binding site [chemical binding]; other site
1076934001466	Switch I region; other site
1076934001467	G2 box; other site
1076934001468	G3 box; other site
1076934001469	Switch II region; other site
1076934001470	G4 box; other site
1076934001471	G5 box; other site
1076934001472	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1076934001473	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1076934001474	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
1076934001475	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1076934001476	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1076934001477	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1076934001478	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1076934001479	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1076934001480	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1076934001481	homodimer interface [polypeptide binding]; other site
1076934001482	active site
1076934001483	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1076934001484	Cell division protein FtsQ; Region: FtsQ; pfam03799
1076934001485	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1076934001486	DNA-binding site [nucleotide binding]; DNA binding site
1076934001487	RNA-binding motif; other site
1076934001488	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1076934001489	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934001490	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934001491	Integrase core domain; Region: rve; pfam00665
1076934001492	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1076934001493	Cell division protein FtsA; Region: FtsA; smart00842
1076934001494	Cell division protein FtsA; Region: FtsA; pfam14450
1076934001495	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
1076934001496	cell division protein FtsZ; Validated; Region: PRK09330
1076934001497	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1076934001498	nucleotide binding site [chemical binding]; other site
1076934001499	SulA interaction site; other site
1076934001500	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1076934001501	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1076934001502	catalytic residue [active]
1076934001503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1076934001504	YGGT family; Region: YGGT; pfam02325
1076934001505	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1076934001506	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1076934001507	RNA binding surface [nucleotide binding]; other site
1076934001508	DivIVA protein; Region: DivIVA; pfam05103
1076934001509	DivIVA domain; Region: DivI1A_domain; TIGR03544
1076934001510	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1076934001511	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1076934001512	active site
1076934001513	HIGH motif; other site
1076934001514	nucleotide binding site [chemical binding]; other site
1076934001515	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1076934001516	active site
1076934001517	KMSKS motif; other site
1076934001518	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1076934001519	tRNA binding surface [nucleotide binding]; other site
1076934001520	anticodon binding site; other site
1076934001521	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1076934001522	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
1076934001523	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1076934001524	nudix motif; other site
1076934001525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934001526	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1076934001527	Walker A motif; other site
1076934001528	ATP binding site [chemical binding]; other site
1076934001529	Walker B motif; other site
1076934001530	arginine finger; other site
1076934001531	UvrB/uvrC motif; Region: UVR; pfam02151
1076934001532	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934001533	Walker A motif; other site
1076934001534	ATP binding site [chemical binding]; other site
1076934001535	Walker B motif; other site
1076934001536	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1076934001537	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
1076934001538	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1076934001539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934001540	non-specific DNA binding site [nucleotide binding]; other site
1076934001541	salt bridge; other site
1076934001542	sequence-specific DNA binding site [nucleotide binding]; other site
1076934001543	ornithine carbamoyltransferase; Validated; Region: PRK02102
1076934001544	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1076934001545	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1076934001546	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
1076934001547	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1076934001548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934001549	dimer interface [polypeptide binding]; other site
1076934001550	conserved gate region; other site
1076934001551	putative PBP binding loops; other site
1076934001552	ABC-ATPase subunit interface; other site
1076934001553	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1076934001554	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1076934001555	Walker A/P-loop; other site
1076934001556	ATP binding site [chemical binding]; other site
1076934001557	Q-loop/lid; other site
1076934001558	ABC transporter signature motif; other site
1076934001559	Walker B; other site
1076934001560	D-loop; other site
1076934001561	H-loop/switch region; other site
1076934001562	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1076934001563	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1076934001564	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1076934001565	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1076934001566	G1 box; other site
1076934001567	GTP/Mg2+ binding site [chemical binding]; other site
1076934001568	Switch I region; other site
1076934001569	G2 box; other site
1076934001570	G3 box; other site
1076934001571	Switch II region; other site
1076934001572	G4 box; other site
1076934001573	G5 box; other site
1076934001574	Nucleoside recognition; Region: Gate; pfam07670
1076934001575	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1076934001576	Nucleoside recognition; Region: Gate; pfam07670
1076934001577	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
1076934001578	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1076934001579	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1076934001580	homodimer interface [polypeptide binding]; other site
1076934001581	NADP binding site [chemical binding]; other site
1076934001582	substrate binding site [chemical binding]; other site
1076934001583	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1076934001584	putative substrate binding site [chemical binding]; other site
1076934001585	putative ATP binding site [chemical binding]; other site
1076934001586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1076934001587	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1076934001588	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1076934001589	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1076934001590	generic binding surface II; other site
1076934001591	generic binding surface I; other site
1076934001592	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1076934001593	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1076934001594	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1076934001595	substrate binding pocket [chemical binding]; other site
1076934001596	chain length determination region; other site
1076934001597	substrate-Mg2+ binding site; other site
1076934001598	catalytic residues [active]
1076934001599	aspartate-rich region 1; other site
1076934001600	active site lid residues [active]
1076934001601	aspartate-rich region 2; other site
1076934001602	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1076934001603	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1076934001604	RNA binding surface [nucleotide binding]; other site
1076934001605	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1076934001606	Arginine repressor [Transcription]; Region: ArgR; COG1438
1076934001607	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1076934001608	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1076934001609	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1076934001610	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1076934001611	Walker A/P-loop; other site
1076934001612	ATP binding site [chemical binding]; other site
1076934001613	Q-loop/lid; other site
1076934001614	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1076934001615	Q-loop/lid; other site
1076934001616	ABC transporter signature motif; other site
1076934001617	Walker B; other site
1076934001618	D-loop; other site
1076934001619	H-loop/switch region; other site
1076934001620	EDD domain protein, DegV family; Region: DegV; TIGR00762
1076934001621	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1076934001622	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1076934001623	active site
1076934001624	catalytic triad [active]
1076934001625	oxyanion hole [active]
1076934001626	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
1076934001627	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1076934001628	IHF dimer interface [polypeptide binding]; other site
1076934001629	IHF - DNA interface [nucleotide binding]; other site
1076934001630	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1076934001631	POT family; Region: PTR2; cl17359
1076934001632	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1076934001633	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
1076934001634	active site
1076934001635	FMN binding site [chemical binding]; other site
1076934001636	substrate binding site [chemical binding]; other site
1076934001637	catalytic residues [active]
1076934001638	homodimer interface [polypeptide binding]; other site
1076934001639	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1076934001640	dimerization interface [polypeptide binding]; other site
1076934001641	putative DNA binding site [nucleotide binding]; other site
1076934001642	putative Zn2+ binding site [ion binding]; other site
1076934001643	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1076934001644	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1076934001645	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1076934001646	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1076934001647	catalytic core [active]
1076934001648	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1076934001649	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1076934001650	HTH domain; Region: HTH_11; pfam08279
1076934001651	3H domain; Region: 3H; pfam02829
1076934001652	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1076934001653	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1076934001654	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1076934001655	recombination protein RecR; Reviewed; Region: recR; PRK00076
1076934001656	RecR protein; Region: RecR; pfam02132
1076934001657	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1076934001658	putative active site [active]
1076934001659	putative metal-binding site [ion binding]; other site
1076934001660	tetramer interface [polypeptide binding]; other site
1076934001661	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1076934001662	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1076934001663	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1076934001664	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934001665	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934001666	Integrase core domain; Region: rve; pfam00665
1076934001667	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1076934001668	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1076934001669	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1076934001670	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1076934001671	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1076934001672	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1076934001673	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1076934001674	G1 box; other site
1076934001675	putative GEF interaction site [polypeptide binding]; other site
1076934001676	GTP/Mg2+ binding site [chemical binding]; other site
1076934001677	Switch I region; other site
1076934001678	G2 box; other site
1076934001679	G3 box; other site
1076934001680	Switch II region; other site
1076934001681	G4 box; other site
1076934001682	G5 box; other site
1076934001683	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1076934001684	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1076934001685	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1076934001686	ATP binding site [chemical binding]; other site
1076934001687	Mg++ binding site [ion binding]; other site
1076934001688	motif III; other site
1076934001689	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934001690	nucleotide binding region [chemical binding]; other site
1076934001691	ATP-binding site [chemical binding]; other site
1076934001692	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1076934001693	GIY-YIG motif/motif A; other site
1076934001694	putative active site [active]
1076934001695	putative metal binding site [ion binding]; other site
1076934001696	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1076934001697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934001698	S-adenosylmethionine binding site [chemical binding]; other site
1076934001699	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1076934001700	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1076934001701	putative acyl-acceptor binding pocket; other site
1076934001702	SLBB domain; Region: SLBB; pfam10531
1076934001703	comEA protein; Region: comE; TIGR01259
1076934001704	Helix-hairpin-helix motif; Region: HHH; pfam00633
1076934001705	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1076934001706	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1076934001707	Competence protein; Region: Competence; pfam03772
1076934001708	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1076934001709	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1076934001710	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1076934001711	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1076934001712	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1076934001713	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1076934001714	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1076934001715	hypothetical protein; Validated; Region: PRK00110
1076934001716	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1076934001717	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1076934001718	CCC1-related family of proteins; Region: CCC1_like; cd01059
1076934001719	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1076934001720	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1076934001721	active site
1076934001722	trimer interface [polypeptide binding]; other site
1076934001723	allosteric site; other site
1076934001724	active site lid [active]
1076934001725	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1076934001726	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1076934001727	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1076934001728	RNA binding surface [nucleotide binding]; other site
1076934001729	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1076934001730	active site
1076934001731	uracil binding [chemical binding]; other site
1076934001732	Competence protein CoiA-like family; Region: CoiA; pfam06054
1076934001733	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1076934001734	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1076934001735	active site
1076934001736	Zn binding site [ion binding]; other site
1076934001737	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1076934001738	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1076934001739	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1076934001740	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934001741	motif II; other site
1076934001742	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1076934001743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934001744	S-adenosylmethionine binding site [chemical binding]; other site
1076934001745	foldase protein PrsA; Reviewed; Region: PRK12450
1076934001746	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1076934001747	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1076934001748	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1076934001749	motif 1; other site
1076934001750	active site
1076934001751	motif 2; other site
1076934001752	motif 3; other site
1076934001753	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1076934001754	DHHA1 domain; Region: DHHA1; pfam02272
1076934001755	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1076934001756	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1076934001757	putative active site [active]
1076934001758	catalytic triad [active]
1076934001759	putative dimer interface [polypeptide binding]; other site
1076934001760	transaminase; Reviewed; Region: PRK08068
1076934001761	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1076934001762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934001763	homodimer interface [polypeptide binding]; other site
1076934001764	catalytic residue [active]
1076934001765	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1076934001766	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1076934001767	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1076934001768	heterotetramer interface [polypeptide binding]; other site
1076934001769	active site pocket [active]
1076934001770	cleavage site
1076934001771	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1076934001772	nucleotide binding site [chemical binding]; other site
1076934001773	N-acetyl-L-glutamate binding site [chemical binding]; other site
1076934001774	acetylornithine aminotransferase; Provisional; Region: PRK04260
1076934001775	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1076934001776	inhibitor-cofactor binding pocket; inhibition site
1076934001777	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934001778	catalytic residue [active]
1076934001779	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1076934001780	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1076934001781	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1076934001782	catalytic motif [active]
1076934001783	Zn binding site [ion binding]; other site
1076934001784	RibD C-terminal domain; Region: RibD_C; cl17279
1076934001785	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1076934001786	Lumazine binding domain; Region: Lum_binding; pfam00677
1076934001787	Lumazine binding domain; Region: Lum_binding; pfam00677
1076934001788	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1076934001789	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1076934001790	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1076934001791	dimerization interface [polypeptide binding]; other site
1076934001792	active site
1076934001793	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1076934001794	homopentamer interface [polypeptide binding]; other site
1076934001795	active site
1076934001796	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
1076934001797	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1076934001798	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1076934001799	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1076934001800	dimer interface [polypeptide binding]; other site
1076934001801	putative radical transfer pathway; other site
1076934001802	diiron center [ion binding]; other site
1076934001803	tyrosyl radical; other site
1076934001804	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
1076934001805	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1076934001806	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1076934001807	active site
1076934001808	dimer interface [polypeptide binding]; other site
1076934001809	catalytic residues [active]
1076934001810	effector binding site; other site
1076934001811	R2 peptide binding site; other site
1076934001812	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1076934001813	catalytic residues [active]
1076934001814	aconitate hydratase; Validated; Region: PRK09277
1076934001815	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1076934001816	substrate binding site [chemical binding]; other site
1076934001817	ligand binding site [chemical binding]; other site
1076934001818	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1076934001819	substrate binding site [chemical binding]; other site
1076934001820	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1076934001821	dimer interface [polypeptide binding]; other site
1076934001822	Citrate synthase; Region: Citrate_synt; pfam00285
1076934001823	active site
1076934001824	citrylCoA binding site [chemical binding]; other site
1076934001825	oxalacetate/citrate binding site [chemical binding]; other site
1076934001826	coenzyme A binding site [chemical binding]; other site
1076934001827	catalytic triad [active]
1076934001828	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1076934001829	isocitrate dehydrogenase; Validated; Region: PRK06451
1076934001830	Predicted membrane protein [Function unknown]; Region: COG4905
1076934001831	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
1076934001832	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1076934001833	dimerization domain swap beta strand [polypeptide binding]; other site
1076934001834	regulatory protein interface [polypeptide binding]; other site
1076934001835	active site
1076934001836	regulatory phosphorylation site [posttranslational modification]; other site
1076934001837	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1076934001838	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1076934001839	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1076934001840	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1076934001841	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
1076934001842	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
1076934001843	tetrameric interface [polypeptide binding]; other site
1076934001844	activator binding site; other site
1076934001845	NADP binding site [chemical binding]; other site
1076934001846	substrate binding site [chemical binding]; other site
1076934001847	catalytic residues [active]
1076934001848	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
1076934001849	active site
1076934001850	metal-binding site [ion binding]
1076934001851	active site
1076934001852	nucleotide-binding site [chemical binding]; other site
1076934001853	nucleotide-binding site [chemical binding]; other site
1076934001854	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1076934001855	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1076934001856	ATP binding site [chemical binding]; other site
1076934001857	putative Mg++ binding site [ion binding]; other site
1076934001858	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934001859	nucleotide binding region [chemical binding]; other site
1076934001860	ATP-binding site [chemical binding]; other site
1076934001861	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1076934001862	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1076934001863	Sugar specificity; other site
1076934001864	Pyrimidine base specificity; other site
1076934001865	ATP-binding site [chemical binding]; other site
1076934001866	2-isopropylmalate synthase; Validated; Region: PRK00915
1076934001867	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1076934001868	active site
1076934001869	catalytic residues [active]
1076934001870	metal binding site [ion binding]; metal-binding site
1076934001871	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1076934001872	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1076934001873	tartrate dehydrogenase; Region: TTC; TIGR02089
1076934001874	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
1076934001875	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1076934001876	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1076934001877	substrate binding site [chemical binding]; other site
1076934001878	ligand binding site [chemical binding]; other site
1076934001879	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1076934001880	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1076934001881	substrate binding site [chemical binding]; other site
1076934001882	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1076934001883	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1076934001884	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934001885	Walker A motif; other site
1076934001886	ATP binding site [chemical binding]; other site
1076934001887	Walker B motif; other site
1076934001888	arginine finger; other site
1076934001889	Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209
1076934001890	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
1076934001891	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1076934001892	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1076934001893	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1076934001894	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1076934001895	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1076934001896	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1076934001897	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1076934001898	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1076934001899	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1076934001900	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1076934001901	hinge; other site
1076934001902	active site
1076934001903	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1076934001904	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1076934001905	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1076934001906	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1076934001907	DNA-binding site [nucleotide binding]; DNA binding site
1076934001908	DRTGG domain; Region: DRTGG; pfam07085
1076934001909	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1076934001910	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1076934001911	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1076934001912	active site
1076934001913	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1076934001914	Predicted membrane protein [Function unknown]; Region: COG2246
1076934001915	GtrA-like protein; Region: GtrA; pfam04138
1076934001916	Predicted membrane protein [Function unknown]; Region: COG4708
1076934001917	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1076934001918	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1076934001919	nucleotide binding pocket [chemical binding]; other site
1076934001920	K-X-D-G motif; other site
1076934001921	catalytic site [active]
1076934001922	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1076934001923	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1076934001924	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1076934001925	Dimer interface [polypeptide binding]; other site
1076934001926	BRCT sequence motif; other site
1076934001927	putative lipid kinase; Reviewed; Region: PRK13055
1076934001928	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1076934001929	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
1076934001930	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1076934001931	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1076934001932	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1076934001933	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1076934001934	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1076934001935	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1076934001936	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1076934001937	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1076934001938	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1076934001939	beta subunit interaction interface [polypeptide binding]; other site
1076934001940	Walker A motif; other site
1076934001941	ATP binding site [chemical binding]; other site
1076934001942	Walker B motif; other site
1076934001943	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1076934001944	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1076934001945	core domain interface [polypeptide binding]; other site
1076934001946	delta subunit interface [polypeptide binding]; other site
1076934001947	epsilon subunit interface [polypeptide binding]; other site
1076934001948	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1076934001949	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1076934001950	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1076934001951	alpha subunit interaction interface [polypeptide binding]; other site
1076934001952	Walker A motif; other site
1076934001953	ATP binding site [chemical binding]; other site
1076934001954	Walker B motif; other site
1076934001955	inhibitor binding site; inhibition site
1076934001956	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1076934001957	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1076934001958	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1076934001959	gamma subunit interface [polypeptide binding]; other site
1076934001960	epsilon subunit interface [polypeptide binding]; other site
1076934001961	LBP interface [polypeptide binding]; other site
1076934001962	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1076934001963	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1076934001964	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1076934001965	hinge; other site
1076934001966	active site
1076934001967	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
1076934001968	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1076934001969	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
1076934001970	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1076934001971	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1076934001972	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1076934001973	dimer interface [polypeptide binding]; other site
1076934001974	motif 1; other site
1076934001975	active site
1076934001976	motif 2; other site
1076934001977	motif 3; other site
1076934001978	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1076934001979	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1076934001980	Coenzyme A binding pocket [chemical binding]; other site
1076934001981	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1076934001982	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1076934001983	putative tRNA-binding site [nucleotide binding]; other site
1076934001984	B3/4 domain; Region: B3_4; pfam03483
1076934001985	tRNA synthetase B5 domain; Region: B5; smart00874
1076934001986	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1076934001987	dimer interface [polypeptide binding]; other site
1076934001988	motif 1; other site
1076934001989	motif 3; other site
1076934001990	motif 2; other site
1076934001991	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
1076934001992	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
1076934001993	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1076934001994	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
1076934001995	Part of AAA domain; Region: AAA_19; pfam13245
1076934001996	Family description; Region: UvrD_C_2; pfam13538
1076934001997	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1076934001998	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1076934001999	substrate binding site [chemical binding]; other site
1076934002000	THF binding site; other site
1076934002001	zinc-binding site [ion binding]; other site
1076934002002	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
1076934002003	active site
1076934002004	Zn binding site [ion binding]; other site
1076934002005	hypothetical protein; Provisional; Region: PRK07329
1076934002006	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1076934002007	active site
1076934002008	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1076934002009	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1076934002010	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1076934002011	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1076934002012	HflX GTPase family; Region: HflX; cd01878
1076934002013	G1 box; other site
1076934002014	GTP/Mg2+ binding site [chemical binding]; other site
1076934002015	Switch I region; other site
1076934002016	G2 box; other site
1076934002017	G3 box; other site
1076934002018	Switch II region; other site
1076934002019	G4 box; other site
1076934002020	G5 box; other site
1076934002021	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1076934002022	ribonuclease Z; Region: RNase_Z; TIGR02651
1076934002023	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1076934002024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1076934002025	NAD(P) binding site [chemical binding]; other site
1076934002026	active site
1076934002027	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1076934002028	DHH family; Region: DHH; pfam01368
1076934002029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1076934002030	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1076934002031	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
1076934002032	active site
1076934002033	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934002034	active site
1076934002035	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1076934002036	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1076934002037	proposed active site lysine [active]
1076934002038	conserved cys residue [active]
1076934002039	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1076934002040	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1076934002041	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1076934002042	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1076934002043	minor groove reading motif; other site
1076934002044	helix-hairpin-helix signature motif; other site
1076934002045	substrate binding pocket [chemical binding]; other site
1076934002046	active site
1076934002047	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1076934002048	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1076934002049	Family of unknown function (DUF633); Region: DUF633; pfam04816
1076934002050	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1076934002051	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1076934002052	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1076934002053	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1076934002054	substrate binding site; other site
1076934002055	tetramer interface; other site
1076934002056	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1076934002057	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1076934002058	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1076934002059	NAD binding site [chemical binding]; other site
1076934002060	substrate binding site [chemical binding]; other site
1076934002061	homodimer interface [polypeptide binding]; other site
1076934002062	active site
1076934002063	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1076934002064	putative active site [active]
1076934002065	nucleotide binding site [chemical binding]; other site
1076934002066	nudix motif; other site
1076934002067	putative metal binding site [ion binding]; other site
1076934002068	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1076934002069	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1076934002070	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1076934002071	TPR motif; other site
1076934002072	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1076934002073	binding surface
1076934002074	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1076934002075	binding surface
1076934002076	TPR motif; other site
1076934002077	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1076934002078	acetolactate synthase; Reviewed; Region: PRK08617
1076934002079	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1076934002080	PYR/PP interface [polypeptide binding]; other site
1076934002081	dimer interface [polypeptide binding]; other site
1076934002082	TPP binding site [chemical binding]; other site
1076934002083	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1076934002084	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1076934002085	TPP-binding site [chemical binding]; other site
1076934002086	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1076934002087	amino acid transporter; Region: 2A0306; TIGR00909
1076934002088	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1076934002089	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1076934002090	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1076934002091	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1076934002092	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1076934002093	zinc binding site [ion binding]; other site
1076934002094	putative ligand binding site [chemical binding]; other site
1076934002095	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1076934002096	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1076934002097	TM-ABC transporter signature motif; other site
1076934002098	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1076934002099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934002100	Walker A/P-loop; other site
1076934002101	ATP binding site [chemical binding]; other site
1076934002102	Q-loop/lid; other site
1076934002103	ABC transporter signature motif; other site
1076934002104	Walker B; other site
1076934002105	D-loop; other site
1076934002106	H-loop/switch region; other site
1076934002107	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1076934002108	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1076934002109	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1076934002110	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
1076934002111	active site
1076934002112	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1076934002113	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934002114	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934002115	ABC transporter; Region: ABC_tran_2; pfam12848
1076934002116	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934002117	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1076934002118	MarR family; Region: MarR_2; pfam12802
1076934002119	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1076934002120	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1076934002121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934002122	Walker A/P-loop; other site
1076934002123	ATP binding site [chemical binding]; other site
1076934002124	Q-loop/lid; other site
1076934002125	ABC transporter signature motif; other site
1076934002126	Walker B; other site
1076934002127	D-loop; other site
1076934002128	H-loop/switch region; other site
1076934002129	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1076934002130	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1076934002131	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1076934002132	Walker A/P-loop; other site
1076934002133	ATP binding site [chemical binding]; other site
1076934002134	Q-loop/lid; other site
1076934002135	ABC transporter signature motif; other site
1076934002136	Walker B; other site
1076934002137	D-loop; other site
1076934002138	H-loop/switch region; other site
1076934002139	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1076934002140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1076934002141	Root hair defective 3 GTP-binding protein (RHD3); Region: RHD3; pfam05879
1076934002142	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1076934002143	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1076934002144	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1076934002145	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1076934002146	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934002147	motif II; other site
1076934002148	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1076934002149	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
1076934002150	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1076934002151	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1076934002152	DNA binding residues [nucleotide binding]
1076934002153	putative dimer interface [polypeptide binding]; other site
1076934002154	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1076934002155	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1076934002156	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1076934002157	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1076934002158	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1076934002159	FtsX-like permease family; Region: FtsX; pfam02687
1076934002160	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1076934002161	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1076934002162	Walker A/P-loop; other site
1076934002163	ATP binding site [chemical binding]; other site
1076934002164	Q-loop/lid; other site
1076934002165	ABC transporter signature motif; other site
1076934002166	Walker B; other site
1076934002167	D-loop; other site
1076934002168	H-loop/switch region; other site
1076934002169	Ion channel; Region: Ion_trans_2; pfam07885
1076934002170	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1076934002171	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934002172	motif II; other site
1076934002173	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1076934002174	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1076934002175	ligand binding site [chemical binding]; other site
1076934002176	flexible hinge region; other site
1076934002177	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1076934002178	non-specific DNA interactions [nucleotide binding]; other site
1076934002179	DNA binding site [nucleotide binding]
1076934002180	sequence specific DNA binding site [nucleotide binding]; other site
1076934002181	putative cAMP binding site [chemical binding]; other site
1076934002182	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1076934002183	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1076934002184	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1076934002185	putative dimerization interface [polypeptide binding]; other site
1076934002186	Predicted membrane protein [Function unknown]; Region: COG2855
1076934002187	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1076934002188	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1076934002189	NAD(P) binding site [chemical binding]; other site
1076934002190	catalytic residues [active]
1076934002191	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1076934002192	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1076934002193	GIY-YIG motif/motif A; other site
1076934002194	active site
1076934002195	catalytic site [active]
1076934002196	putative DNA binding site [nucleotide binding]; other site
1076934002197	metal binding site [ion binding]; metal-binding site
1076934002198	UvrB/uvrC motif; Region: UVR; pfam02151
1076934002199	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1076934002200	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
1076934002201	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1076934002202	dimer interface [polypeptide binding]; other site
1076934002203	FMN binding site [chemical binding]; other site
1076934002204	dipeptidase PepV; Reviewed; Region: PRK07318
1076934002205	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1076934002206	active site
1076934002207	metal binding site [ion binding]; metal-binding site
1076934002208	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1076934002209	putative uracil binding site [chemical binding]; other site
1076934002210	putative active site [active]
1076934002211	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1076934002212	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1076934002213	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1076934002214	G1 box; other site
1076934002215	GTP/Mg2+ binding site [chemical binding]; other site
1076934002216	Switch I region; other site
1076934002217	G2 box; other site
1076934002218	Switch II region; other site
1076934002219	G3 box; other site
1076934002220	G4 box; other site
1076934002221	G5 box; other site
1076934002222	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1076934002223	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1076934002224	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1076934002225	active site
1076934002226	dimer interface [polypeptide binding]; other site
1076934002227	phosphopentomutase; Provisional; Region: PRK05362
1076934002228	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1076934002229	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1076934002230	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
1076934002231	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1076934002232	putative ion selectivity filter; other site
1076934002233	putative pore gating glutamate residue; other site
1076934002234	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1076934002235	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1076934002236	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
1076934002237	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1076934002238	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1076934002239	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1076934002240	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1076934002241	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1076934002242	dimerization interface [polypeptide binding]; other site
1076934002243	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
1076934002244	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
1076934002245	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1076934002246	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
1076934002247	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1076934002248	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1076934002249	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1076934002250	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1076934002251	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1076934002252	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1076934002253	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1076934002254	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1076934002255	Ligand binding site; other site
1076934002256	metal-binding site
1076934002257	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1076934002258	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1076934002259	NAD(P) binding site [chemical binding]; other site
1076934002260	active site
1076934002261	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1076934002262	active site
1076934002263	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
1076934002264	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1076934002265	extended (e) SDRs; Region: SDR_e; cd08946
1076934002266	NAD(P) binding site [chemical binding]; other site
1076934002267	substrate binding site [chemical binding]; other site
1076934002268	active site
1076934002269	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1076934002270	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1076934002271	putative NAD(P) binding site [chemical binding]; other site
1076934002272	active site
1076934002273	putative substrate binding site [chemical binding]; other site
1076934002274	Protein of unknown function (DUF616); Region: DUF616; pfam04765
1076934002275	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1076934002276	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1076934002277	active site
1076934002278	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1076934002279	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1076934002280	UDP-galactopyranose mutase; Region: GLF; pfam03275
1076934002281	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1076934002282	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1076934002283	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1076934002284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934002285	non-specific DNA binding site [nucleotide binding]; other site
1076934002286	salt bridge; other site
1076934002287	sequence-specific DNA binding site [nucleotide binding]; other site
1076934002288	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1076934002289	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1076934002290	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1076934002291	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1076934002292	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1076934002293	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1076934002294	NADP binding site [chemical binding]; other site
1076934002295	active site
1076934002296	putative substrate binding site [chemical binding]; other site
1076934002297	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1076934002298	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1076934002299	FAD binding pocket [chemical binding]; other site
1076934002300	FAD binding motif [chemical binding]; other site
1076934002301	phosphate binding motif [ion binding]; other site
1076934002302	beta-alpha-beta structure motif; other site
1076934002303	NAD binding pocket [chemical binding]; other site
1076934002304	Iron coordination center [ion binding]; other site
1076934002305	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1076934002306	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1076934002307	heterodimer interface [polypeptide binding]; other site
1076934002308	active site
1076934002309	FMN binding site [chemical binding]; other site
1076934002310	homodimer interface [polypeptide binding]; other site
1076934002311	substrate binding site [chemical binding]; other site
1076934002312	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1076934002313	active site
1076934002314	dimer interface [polypeptide binding]; other site
1076934002315	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934002316	active site
1076934002317	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1076934002318	substrate binding site [chemical binding]; other site
1076934002319	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1076934002320	ligand binding site [chemical binding]; other site
1076934002321	active site
1076934002322	UGI interface [polypeptide binding]; other site
1076934002323	catalytic site [active]
1076934002324	dihydroorotase; Validated; Region: pyrC; PRK09357
1076934002325	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1076934002326	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1076934002327	active site
1076934002328	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1076934002329	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
1076934002330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934002331	Mg2+ binding site [ion binding]; other site
1076934002332	G-X-G motif; other site
1076934002333	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1076934002334	anchoring element; other site
1076934002335	dimer interface [polypeptide binding]; other site
1076934002336	ATP binding site [chemical binding]; other site
1076934002337	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1076934002338	active site
1076934002339	putative metal-binding site [ion binding]; other site
1076934002340	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1076934002341	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
1076934002342	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1076934002343	CAP-like domain; other site
1076934002344	active site
1076934002345	primary dimer interface [polypeptide binding]; other site
1076934002346	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1076934002347	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1076934002348	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1076934002349	homodimer interface [polypeptide binding]; other site
1076934002350	substrate-cofactor binding pocket; other site
1076934002351	catalytic residue [active]
1076934002352	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
1076934002353	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1076934002354	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1076934002355	RNA binding site [nucleotide binding]; other site
1076934002356	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1076934002357	RNA binding site [nucleotide binding]; other site
1076934002358	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1076934002359	RNA binding site [nucleotide binding]; other site
1076934002360	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1076934002361	RNA binding site [nucleotide binding]; other site
1076934002362	LrgB-like family; Region: LrgB; pfam04172
1076934002363	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1076934002364	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1076934002365	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1076934002366	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1076934002367	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934002368	Walker A/P-loop; other site
1076934002369	ATP binding site [chemical binding]; other site
1076934002370	Q-loop/lid; other site
1076934002371	ABC transporter signature motif; other site
1076934002372	Walker B; other site
1076934002373	D-loop; other site
1076934002374	H-loop/switch region; other site
1076934002375	Predicted transcriptional regulators [Transcription]; Region: COG1725
1076934002376	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1076934002377	DNA-binding site [nucleotide binding]; DNA binding site
1076934002378	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
1076934002379	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1076934002380	active site
1076934002381	PHP Thumb interface [polypeptide binding]; other site
1076934002382	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1076934002383	generic binding surface II; other site
1076934002384	generic binding surface I; other site
1076934002385	6-phosphofructokinase; Provisional; Region: PRK03202
1076934002386	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1076934002387	active site
1076934002388	ADP/pyrophosphate binding site [chemical binding]; other site
1076934002389	dimerization interface [polypeptide binding]; other site
1076934002390	allosteric effector site; other site
1076934002391	fructose-1,6-bisphosphate binding site; other site
1076934002392	pyruvate kinase; Provisional; Region: PRK05826
1076934002393	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1076934002394	domain interfaces; other site
1076934002395	active site
1076934002396	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1076934002397	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
1076934002398	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1076934002399	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1076934002400	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1076934002401	glutaminase active site [active]
1076934002402	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1076934002403	dimer interface [polypeptide binding]; other site
1076934002404	active site
1076934002405	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1076934002406	dimer interface [polypeptide binding]; other site
1076934002407	active site
1076934002408	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1076934002409	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1076934002410	PhnA protein; Region: PhnA; pfam03831
1076934002411	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1076934002412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934002413	dimer interface [polypeptide binding]; other site
1076934002414	conserved gate region; other site
1076934002415	ABC-ATPase subunit interface; other site
1076934002416	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1076934002417	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934002418	Walker A/P-loop; other site
1076934002419	ATP binding site [chemical binding]; other site
1076934002420	Q-loop/lid; other site
1076934002421	ABC transporter signature motif; other site
1076934002422	Walker B; other site
1076934002423	D-loop; other site
1076934002424	H-loop/switch region; other site
1076934002425	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934002426	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934002427	substrate binding pocket [chemical binding]; other site
1076934002428	membrane-bound complex binding site; other site
1076934002429	hinge residues; other site
1076934002430	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1076934002431	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1076934002432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
1076934002433	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1076934002434	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1076934002435	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1076934002436	catalytic core [active]
1076934002437	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1076934002438	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1076934002439	hypothetical protein; Reviewed; Region: PRK00024
1076934002440	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1076934002441	MPN+ (JAMM) motif; other site
1076934002442	Zinc-binding site [ion binding]; other site
1076934002443	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1076934002444	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1076934002445	CoA binding domain; Region: CoA_binding; pfam02629
1076934002446	Putative amino acid metabolism; Region: DUF1831; pfam08866
1076934002447	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1076934002448	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1076934002449	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1076934002450	catalytic residue [active]
1076934002451	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
1076934002452	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1076934002453	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934002454	active site
1076934002455	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1076934002456	putative active site [active]
1076934002457	putative metal binding residues [ion binding]; other site
1076934002458	signature motif; other site
1076934002459	putative triphosphate binding site [ion binding]; other site
1076934002460	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1076934002461	synthetase active site [active]
1076934002462	NTP binding site [chemical binding]; other site
1076934002463	metal binding site [ion binding]; metal-binding site
1076934002464	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1076934002465	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1076934002466	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1076934002467	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1076934002468	active site
1076934002469	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1076934002470	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1076934002471	malonic semialdehyde reductase; Provisional; Region: PRK10538
1076934002472	putative NAD(P) binding site [chemical binding]; other site
1076934002473	homotetramer interface [polypeptide binding]; other site
1076934002474	homodimer interface [polypeptide binding]; other site
1076934002475	active site
1076934002476	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1076934002477	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1076934002478	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1076934002479	beta-galactosidase; Region: BGL; TIGR03356
1076934002480	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1076934002481	ABC transporter; Region: ABC_tran; pfam00005
1076934002482	Q-loop/lid; other site
1076934002483	ABC transporter signature motif; other site
1076934002484	Walker B; other site
1076934002485	D-loop; other site
1076934002486	H-loop/switch region; other site
1076934002487	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1076934002488	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1076934002489	active site
1076934002490	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934002491	active site
1076934002492	xanthine permease; Region: pbuX; TIGR03173
1076934002493	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1076934002494	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934002495	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934002496	Integrase core domain; Region: rve; pfam00665
1076934002497	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1076934002498	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1076934002499	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1076934002500	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1076934002501	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
1076934002502	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1076934002503	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1076934002504	intersubunit interface [polypeptide binding]; other site
1076934002505	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
1076934002506	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1076934002507	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1076934002508	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1076934002509	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1076934002510	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
1076934002511	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1076934002512	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1076934002513	PYR/PP interface [polypeptide binding]; other site
1076934002514	dimer interface [polypeptide binding]; other site
1076934002515	TPP binding site [chemical binding]; other site
1076934002516	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
1076934002517	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1076934002518	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1076934002519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1076934002520	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1076934002521	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1076934002522	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
1076934002523	SecY translocase; Region: SecY; pfam00344
1076934002524	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1076934002525	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1076934002526	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1076934002527	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
1076934002528	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1076934002529	ATP binding site [chemical binding]; other site
1076934002530	putative Mg++ binding site [ion binding]; other site
1076934002531	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1076934002532	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1076934002533	nucleotide binding region [chemical binding]; other site
1076934002534	ATP-binding site [chemical binding]; other site
1076934002535	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1076934002536	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1076934002537	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1076934002538	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1076934002539	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1076934002540	active site
1076934002541	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
1076934002542	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1076934002543	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1076934002544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1076934002545	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1076934002546	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1076934002547	HTH-like domain; Region: HTH_21; pfam13276
1076934002548	Integrase core domain; Region: rve; pfam00665
1076934002549	Integrase core domain; Region: rve_3; cl15866
1076934002550	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
1076934002551	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1076934002552	active site
1076934002553	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1076934002554	active site
1076934002555	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1076934002556	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1076934002557	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1076934002558	HTH-like domain; Region: HTH_21; pfam13276
1076934002559	Integrase core domain; Region: rve; pfam00665
1076934002560	Integrase core domain; Region: rve_3; cl15866
1076934002561	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1076934002562	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1076934002563	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1076934002564	ApbE family; Region: ApbE; pfam02424
1076934002565	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
1076934002566	active site 1 [active]
1076934002567	dimer interface [polypeptide binding]; other site
1076934002568	hexamer interface [polypeptide binding]; other site
1076934002569	active site 2 [active]
1076934002570	putative transposase OrfB; Reviewed; Region: PHA02517
1076934002571	HTH-like domain; Region: HTH_21; pfam13276
1076934002572	Integrase core domain; Region: rve; pfam00665
1076934002573	Integrase core domain; Region: rve_2; pfam13333
1076934002574	thymidine kinase; Provisional; Region: PRK04296
1076934002575	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1076934002576	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1076934002577	RF-1 domain; Region: RF-1; pfam00472
1076934002578	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1076934002579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934002580	S-adenosylmethionine binding site [chemical binding]; other site
1076934002581	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1076934002582	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
1076934002583	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1076934002584	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1076934002585	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1076934002586	catalytic residue [active]
1076934002587	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1076934002588	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1076934002589	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1076934002590	Walker A/P-loop; other site
1076934002591	ATP binding site [chemical binding]; other site
1076934002592	Q-loop/lid; other site
1076934002593	ABC transporter signature motif; other site
1076934002594	Walker B; other site
1076934002595	D-loop; other site
1076934002596	H-loop/switch region; other site
1076934002597	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1076934002598	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1076934002599	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1076934002600	Walker A/P-loop; other site
1076934002601	ATP binding site [chemical binding]; other site
1076934002602	Q-loop/lid; other site
1076934002603	ABC transporter signature motif; other site
1076934002604	Walker B; other site
1076934002605	D-loop; other site
1076934002606	H-loop/switch region; other site
1076934002607	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1076934002608	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1076934002609	active site
1076934002610	Na/Ca binding site [ion binding]; other site
1076934002611	catalytic site [active]
1076934002612	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
1076934002613	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1076934002614	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1076934002615	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1076934002616	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1076934002617	tetramer interface [polypeptide binding]; other site
1076934002618	TPP-binding site [chemical binding]; other site
1076934002619	heterodimer interface [polypeptide binding]; other site
1076934002620	phosphorylation loop region [posttranslational modification]
1076934002621	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1076934002622	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1076934002623	alpha subunit interface [polypeptide binding]; other site
1076934002624	TPP binding site [chemical binding]; other site
1076934002625	heterodimer interface [polypeptide binding]; other site
1076934002626	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1076934002627	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1076934002628	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1076934002629	E3 interaction surface; other site
1076934002630	lipoyl attachment site [posttranslational modification]; other site
1076934002631	e3 binding domain; Region: E3_binding; pfam02817
1076934002632	e3 binding domain; Region: E3_binding; pfam02817
1076934002633	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1076934002634	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1076934002635	E3 interaction surface; other site
1076934002636	lipoyl attachment site [posttranslational modification]; other site
1076934002637	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
1076934002638	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1076934002639	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1076934002640	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1076934002641	EamA-like transporter family; Region: EamA; pfam00892
1076934002642	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1076934002643	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1076934002644	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1076934002645	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
1076934002646	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1076934002647	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1076934002648	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
1076934002649	ADP-ribose binding site [chemical binding]; other site
1076934002650	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1076934002651	active site residue [active]
1076934002652	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1076934002653	active site residue [active]
1076934002654	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1076934002655	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1076934002656	Zn2+ binding site [ion binding]; other site
1076934002657	Mg2+ binding site [ion binding]; other site
1076934002658	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1076934002659	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1076934002660	Coenzyme A binding pocket [chemical binding]; other site
1076934002661	GMP synthase; Reviewed; Region: guaA; PRK00074
1076934002662	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1076934002663	AMP/PPi binding site [chemical binding]; other site
1076934002664	candidate oxyanion hole; other site
1076934002665	catalytic triad [active]
1076934002666	potential glutamine specificity residues [chemical binding]; other site
1076934002667	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1076934002668	ATP Binding subdomain [chemical binding]; other site
1076934002669	Dimerization subdomain; other site
1076934002670	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1076934002671	nudix motif; other site
1076934002672	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1076934002673	CAAX protease self-immunity; Region: Abi; cl00558
1076934002674	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1076934002675	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1076934002676	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1076934002677	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934002678	non-specific DNA binding site [nucleotide binding]; other site
1076934002679	salt bridge; other site
1076934002680	sequence-specific DNA binding site [nucleotide binding]; other site
1076934002681	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1076934002682	Catalytic site [active]
1076934002683	DNA polymerase IV; Reviewed; Region: PRK03103
1076934002684	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1076934002685	active site
1076934002686	DNA binding site [nucleotide binding]
1076934002687	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1076934002688	YolD-like protein; Region: YolD; pfam08863
1076934002689	T5orf172 domain; Region: T5orf172; pfam10544
1076934002690	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1076934002691	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1076934002692	ATP binding site [chemical binding]; other site
1076934002693	putative Mg++ binding site [ion binding]; other site
1076934002694	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1076934002695	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
1076934002696	AAA domain; Region: AAA_21; pfam13304
1076934002697	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1076934002698	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1076934002699	DNA-binding site [nucleotide binding]; DNA binding site
1076934002700	UTRA domain; Region: UTRA; pfam07702
1076934002701	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1076934002702	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1076934002703	signal recognition particle protein; Provisional; Region: PRK10867
1076934002704	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1076934002705	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1076934002706	P loop; other site
1076934002707	GTP binding site [chemical binding]; other site
1076934002708	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1076934002709	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1076934002710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934002711	active site
1076934002712	motif I; other site
1076934002713	motif II; other site
1076934002714	VanW like protein; Region: VanW; pfam04294
1076934002715	1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Provisional; Region: PRK13585
1076934002716	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1076934002717	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934002718	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934002719	ABC transporter signature motif; other site
1076934002720	Walker B; other site
1076934002721	D-loop; other site
1076934002722	H-loop/switch region; other site
1076934002723	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
1076934002724	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1076934002725	active site
1076934002726	DNA binding site [nucleotide binding]
1076934002727	Int/Topo IB signature motif; other site
1076934002728	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1076934002729	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934002730	non-specific DNA binding site [nucleotide binding]; other site
1076934002731	salt bridge; other site
1076934002732	sequence-specific DNA binding site [nucleotide binding]; other site
1076934002733	Predicted transcriptional regulator [Transcription]; Region: COG2932
1076934002734	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1076934002735	Catalytic site [active]
1076934002736	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1076934002737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934002738	ATP binding site [chemical binding]; other site
1076934002739	Mg2+ binding site [ion binding]; other site
1076934002740	G-X-G motif; other site
1076934002741	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934002742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934002743	active site
1076934002744	phosphorylation site [posttranslational modification]
1076934002745	intermolecular recognition site; other site
1076934002746	dimerization interface [polypeptide binding]; other site
1076934002747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934002748	DNA binding site [nucleotide binding]
1076934002749	FtsX-like permease family; Region: FtsX; pfam02687
1076934002750	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1076934002751	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1076934002752	Walker A/P-loop; other site
1076934002753	ATP binding site [chemical binding]; other site
1076934002754	Q-loop/lid; other site
1076934002755	ABC transporter signature motif; other site
1076934002756	Walker B; other site
1076934002757	D-loop; other site
1076934002758	H-loop/switch region; other site
1076934002759	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1076934002760	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1076934002761	Glucose inhibited division protein A; Region: GIDA; pfam01134
1076934002762	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
1076934002763	DNA topoisomerase I; Validated; Region: PRK05582
1076934002764	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1076934002765	active site
1076934002766	interdomain interaction site; other site
1076934002767	putative metal-binding site [ion binding]; other site
1076934002768	nucleotide binding site [chemical binding]; other site
1076934002769	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1076934002770	domain I; other site
1076934002771	DNA binding groove [nucleotide binding]
1076934002772	phosphate binding site [ion binding]; other site
1076934002773	domain II; other site
1076934002774	domain III; other site
1076934002775	nucleotide binding site [chemical binding]; other site
1076934002776	catalytic site [active]
1076934002777	domain IV; other site
1076934002778	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1076934002779	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1076934002780	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1076934002781	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
1076934002782	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1076934002783	active site
1076934002784	catalytic site [active]
1076934002785	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
1076934002786	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1076934002787	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1076934002788	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1076934002789	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1076934002790	CHAP domain; Region: CHAP; cl17642
1076934002791	AAA-like domain; Region: AAA_10; pfam12846
1076934002792	Protein of unknown function DUF262; Region: DUF262; pfam03235
1076934002793	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1076934002794	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1076934002795	cofactor binding site; other site
1076934002796	DNA binding site [nucleotide binding]
1076934002797	substrate interaction site [chemical binding]; other site
1076934002798	BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533
1076934002799	Dimer interface [polypeptide binding]; other site
1076934002800	BRCT sequence motif; other site
1076934002801	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1076934002802	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1076934002803	Walker A motif; other site
1076934002804	ATP binding site [chemical binding]; other site
1076934002805	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
1076934002806	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1076934002807	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934002808	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934002809	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934002810	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934002811	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934002812	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934002813	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934002814	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934002815	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1076934002816	putative active site [active]
1076934002817	putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726
1076934002818	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1076934002819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934002820	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1076934002821	Walker A motif; other site
1076934002822	ATP binding site [chemical binding]; other site
1076934002823	Walker B motif; other site
1076934002824	arginine finger; other site
1076934002825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934002826	Walker A motif; other site
1076934002827	ATP binding site [chemical binding]; other site
1076934002828	Walker B motif; other site
1076934002829	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1076934002830	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1076934002831	active site
1076934002832	putative interdomain interaction site [polypeptide binding]; other site
1076934002833	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
1076934002834	putative metal-binding site [ion binding]; other site
1076934002835	putative nucleotide binding site [chemical binding]; other site
1076934002836	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1076934002837	domain I; other site
1076934002838	DNA binding groove [nucleotide binding]
1076934002839	phosphate binding site [ion binding]; other site
1076934002840	domain II; other site
1076934002841	domain III; other site
1076934002842	nucleotide binding site [chemical binding]; other site
1076934002843	catalytic site [active]
1076934002844	domain IV; other site
1076934002845	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1076934002846	Toprim-like; Region: Toprim_2; pfam13155
1076934002847	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1076934002848	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1076934002849	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1076934002850	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1076934002851	catalytic residues [active]
1076934002852	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
1076934002853	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1076934002854	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
1076934002855	cofactor binding site; other site
1076934002856	DNA binding site [nucleotide binding]
1076934002857	substrate interaction site [chemical binding]; other site
1076934002858	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1076934002859	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1076934002860	DNA protecting protein DprA; Region: dprA; TIGR00732
1076934002861	maltose O-acetyltransferase; Provisional; Region: PRK10092
1076934002862	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1076934002863	active site
1076934002864	substrate binding site [chemical binding]; other site
1076934002865	trimer interface [polypeptide binding]; other site
1076934002866	CoA binding site [chemical binding]; other site
1076934002867	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1076934002868	RNA/DNA hybrid binding site [nucleotide binding]; other site
1076934002869	active site
1076934002870	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1076934002871	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1076934002872	GTP/Mg2+ binding site [chemical binding]; other site
1076934002873	G4 box; other site
1076934002874	G5 box; other site
1076934002875	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1076934002876	G1 box; other site
1076934002877	G1 box; other site
1076934002878	GTP/Mg2+ binding site [chemical binding]; other site
1076934002879	Switch I region; other site
1076934002880	G2 box; other site
1076934002881	G2 box; other site
1076934002882	G3 box; other site
1076934002883	G3 box; other site
1076934002884	Switch II region; other site
1076934002885	Switch II region; other site
1076934002886	G4 box; other site
1076934002887	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
1076934002888	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1076934002889	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934002890	dimer interface [polypeptide binding]; other site
1076934002891	phosphorylation site [posttranslational modification]
1076934002892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934002893	ATP binding site [chemical binding]; other site
1076934002894	Mg2+ binding site [ion binding]; other site
1076934002895	G-X-G motif; other site
1076934002896	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934002897	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934002898	DNA binding site [nucleotide binding]
1076934002899	Response regulator receiver domain; Region: Response_reg; pfam00072
1076934002900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934002901	active site
1076934002902	phosphorylation site [posttranslational modification]
1076934002903	intermolecular recognition site; other site
1076934002904	dimerization interface [polypeptide binding]; other site
1076934002905	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
1076934002906	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
1076934002907	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1076934002908	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1076934002909	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1076934002910	Walker A/P-loop; other site
1076934002911	ATP binding site [chemical binding]; other site
1076934002912	Q-loop/lid; other site
1076934002913	ABC transporter signature motif; other site
1076934002914	Walker B; other site
1076934002915	D-loop; other site
1076934002916	H-loop/switch region; other site
1076934002917	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1076934002918	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934002919	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934002920	ABC transporter; Region: ABC_tran_2; pfam12848
1076934002921	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934002922	Predicted membrane protein [Function unknown]; Region: COG4720
1076934002923	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1076934002924	dimer interface [polypeptide binding]; other site
1076934002925	pyridoxal binding site [chemical binding]; other site
1076934002926	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1076934002927	ATP binding site [chemical binding]; other site
1076934002928	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1076934002929	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1076934002930	DNA-binding site [nucleotide binding]; DNA binding site
1076934002931	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1076934002932	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934002933	homodimer interface [polypeptide binding]; other site
1076934002934	catalytic residue [active]
1076934002935	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1076934002936	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1076934002937	dimer interface [polypeptide binding]; other site
1076934002938	active site
1076934002939	catalytic residue [active]
1076934002940	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1076934002941	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1076934002942	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1076934002943	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1076934002944	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
1076934002945	putative active site [active]
1076934002946	catalytic site [active]
1076934002947	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
1076934002948	putative active site [active]
1076934002949	catalytic site [active]
1076934002950	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1076934002951	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1076934002952	Potassium binding sites [ion binding]; other site
1076934002953	Cesium cation binding sites [ion binding]; other site
1076934002954	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
1076934002955	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
1076934002956	Flavoprotein; Region: Flavoprotein; pfam02441
1076934002957	Predicted membrane protein [Function unknown]; Region: COG4684
1076934002958	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1076934002959	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1076934002960	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1076934002961	active site
1076934002962	substrate binding site [chemical binding]; other site
1076934002963	metal binding site [ion binding]; metal-binding site
1076934002964	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1076934002965	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
1076934002966	gating phenylalanine in ion channel; other site
1076934002967	Predicted secreted protein [Function unknown]; Region: COG4086
1076934002968	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1076934002969	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1076934002970	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1076934002971	putative metal binding site [ion binding]; other site
1076934002972	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1076934002973	active site
1076934002974	catalytic site [active]
1076934002975	DNA gyrase subunit A; Validated; Region: PRK05560
1076934002976	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1076934002977	CAP-like domain; other site
1076934002978	active site
1076934002979	primary dimer interface [polypeptide binding]; other site
1076934002980	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1076934002981	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1076934002982	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1076934002983	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1076934002984	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1076934002985	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1076934002986	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1076934002987	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1076934002988	NAD binding site [chemical binding]; other site
1076934002989	dimer interface [polypeptide binding]; other site
1076934002990	substrate binding site [chemical binding]; other site
1076934002991	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1076934002992	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1076934002993	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1076934002994	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1076934002995	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1076934002996	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934002997	Walker A/P-loop; other site
1076934002998	ATP binding site [chemical binding]; other site
1076934002999	Q-loop/lid; other site
1076934003000	ABC transporter signature motif; other site
1076934003001	Walker B; other site
1076934003002	D-loop; other site
1076934003003	H-loop/switch region; other site
1076934003004	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1076934003005	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1076934003006	ligand binding site [chemical binding]; other site
1076934003007	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1076934003008	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1076934003009	intersubunit interface [polypeptide binding]; other site
1076934003010	active site
1076934003011	catalytic residue [active]
1076934003012	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1076934003013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934003014	S-adenosylmethionine binding site [chemical binding]; other site
1076934003015	pantothenate kinase; Provisional; Region: PRK05439
1076934003016	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1076934003017	ATP-binding site [chemical binding]; other site
1076934003018	CoA-binding site [chemical binding]; other site
1076934003019	Mg2+-binding site [ion binding]; other site
1076934003020	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1076934003021	HTH-like domain; Region: HTH_21; pfam13276
1076934003022	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1076934003023	Integrase core domain; Region: rve; pfam00665
1076934003024	Integrase core domain; Region: rve_2; pfam13333
1076934003025	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1076934003026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934003027	dimer interface [polypeptide binding]; other site
1076934003028	phosphorylation site [posttranslational modification]
1076934003029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934003030	ATP binding site [chemical binding]; other site
1076934003031	Mg2+ binding site [ion binding]; other site
1076934003032	G-X-G motif; other site
1076934003033	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934003034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934003035	active site
1076934003036	phosphorylation site [posttranslational modification]
1076934003037	intermolecular recognition site; other site
1076934003038	dimerization interface [polypeptide binding]; other site
1076934003039	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934003040	DNA binding site [nucleotide binding]
1076934003041	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
1076934003042	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
1076934003043	Zn binding site [ion binding]; other site
1076934003044	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1076934003045	PhoU domain; Region: PhoU; pfam01895
1076934003046	PhoU domain; Region: PhoU; pfam01895
1076934003047	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
1076934003048	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1076934003049	Walker A/P-loop; other site
1076934003050	ATP binding site [chemical binding]; other site
1076934003051	Q-loop/lid; other site
1076934003052	ABC transporter signature motif; other site
1076934003053	Walker B; other site
1076934003054	D-loop; other site
1076934003055	H-loop/switch region; other site
1076934003056	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
1076934003057	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1076934003058	Walker A/P-loop; other site
1076934003059	ATP binding site [chemical binding]; other site
1076934003060	Q-loop/lid; other site
1076934003061	ABC transporter signature motif; other site
1076934003062	Walker B; other site
1076934003063	D-loop; other site
1076934003064	H-loop/switch region; other site
1076934003065	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1076934003066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003067	dimer interface [polypeptide binding]; other site
1076934003068	conserved gate region; other site
1076934003069	putative PBP binding loops; other site
1076934003070	ABC-ATPase subunit interface; other site
1076934003071	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1076934003072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003073	dimer interface [polypeptide binding]; other site
1076934003074	conserved gate region; other site
1076934003075	putative PBP binding loops; other site
1076934003076	ABC-ATPase subunit interface; other site
1076934003077	phosphate binding protein; Region: ptsS_2; TIGR02136
1076934003078	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1076934003079	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1076934003080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934003081	S-adenosylmethionine binding site [chemical binding]; other site
1076934003082	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1076934003083	glutathione reductase; Validated; Region: PRK06116
1076934003084	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1076934003085	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1076934003086	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1076934003087	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1076934003088	catalytic residues [active]
1076934003089	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1076934003090	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1076934003091	ZIP Zinc transporter; Region: Zip; pfam02535
1076934003092	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1076934003093	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1076934003094	active site
1076934003095	hypothetical protein; Provisional; Region: PRK04387
1076934003096	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1076934003097	ArsC family; Region: ArsC; pfam03960
1076934003098	putative catalytic residues [active]
1076934003099	thiol/disulfide switch; other site
1076934003100	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1076934003101	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1076934003102	active site
1076934003103	Riboflavin kinase; Region: Flavokinase; smart00904
1076934003104	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
1076934003105	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1076934003106	RNA binding site [nucleotide binding]; other site
1076934003107	active site
1076934003108	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1076934003109	Uncharacterized conserved protein [Function unknown]; Region: COG2461
1076934003110	Family of unknown function (DUF438); Region: DUF438; pfam04282
1076934003111	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1076934003112	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
1076934003113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
1076934003114	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
1076934003115	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
1076934003116	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1076934003117	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1076934003118	GA module; Region: GA; cl08325
1076934003119	FtsX-like permease family; Region: FtsX; pfam02687
1076934003120	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1076934003121	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1076934003122	FtsX-like permease family; Region: FtsX; pfam02687
1076934003123	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1076934003124	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1076934003125	Walker A/P-loop; other site
1076934003126	ATP binding site [chemical binding]; other site
1076934003127	Q-loop/lid; other site
1076934003128	ABC transporter signature motif; other site
1076934003129	Walker B; other site
1076934003130	D-loop; other site
1076934003131	H-loop/switch region; other site
1076934003132	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1076934003133	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1076934003134	dimer interface [polypeptide binding]; other site
1076934003135	catalytic triad [active]
1076934003136	peroxidatic and resolving cysteines [active]
1076934003137	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1076934003138	Part of AAA domain; Region: AAA_19; pfam13245
1076934003139	AAA domain; Region: AAA_12; pfam13087
1076934003140	Family description; Region: UvrD_C_2; pfam13538
1076934003141	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1076934003142	conserved cys residue [active]
1076934003143	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1076934003144	amino acid carrier protein; Region: agcS; TIGR00835
1076934003145	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1076934003146	putative transposase OrfB; Reviewed; Region: PHA02517
1076934003147	HTH-like domain; Region: HTH_21; pfam13276
1076934003148	Integrase core domain; Region: rve; pfam00665
1076934003149	Integrase core domain; Region: rve_3; pfam13683
1076934003150	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1076934003151	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1076934003152	dimerization interface [polypeptide binding]; other site
1076934003153	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1076934003154	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934003155	dimer interface [polypeptide binding]; other site
1076934003156	phosphorylation site [posttranslational modification]
1076934003157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934003158	ATP binding site [chemical binding]; other site
1076934003159	Mg2+ binding site [ion binding]; other site
1076934003160	G-X-G motif; other site
1076934003161	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934003162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934003163	active site
1076934003164	phosphorylation site [posttranslational modification]
1076934003165	intermolecular recognition site; other site
1076934003166	dimerization interface [polypeptide binding]; other site
1076934003167	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934003168	DNA binding site [nucleotide binding]
1076934003169	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1076934003170	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1076934003171	FtsX-like permease family; Region: FtsX; pfam02687
1076934003172	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1076934003173	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1076934003174	Walker A/P-loop; other site
1076934003175	ATP binding site [chemical binding]; other site
1076934003176	Q-loop/lid; other site
1076934003177	ABC transporter signature motif; other site
1076934003178	Walker B; other site
1076934003179	D-loop; other site
1076934003180	H-loop/switch region; other site
1076934003181	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1076934003182	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1076934003183	FtsX-like permease family; Region: FtsX; pfam02687
1076934003184	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1076934003185	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
1076934003186	active site
1076934003187	catalytic triad [active]
1076934003188	oxyanion hole [active]
1076934003189	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934003190	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1076934003191	active site
1076934003192	motif I; other site
1076934003193	motif II; other site
1076934003194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934003195	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1076934003196	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1076934003197	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1076934003198	methionine cluster; other site
1076934003199	active site
1076934003200	phosphorylation site [posttranslational modification]
1076934003201	metal binding site [ion binding]; metal-binding site
1076934003202	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1076934003203	PRD domain; Region: PRD; pfam00874
1076934003204	PRD domain; Region: PRD; pfam00874
1076934003205	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1076934003206	active site
1076934003207	P-loop; other site
1076934003208	phosphorylation site [posttranslational modification]
1076934003209	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1076934003210	active site
1076934003211	phosphorylation site [posttranslational modification]
1076934003212	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
1076934003213	active site
1076934003214	P-loop; other site
1076934003215	phosphorylation site [posttranslational modification]
1076934003216	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1076934003217	Uncharacterized conserved protein [Function unknown]; Region: COG4095
1076934003218	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
1076934003219	beta-galactosidase; Region: BGL; TIGR03356
1076934003220	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1076934003221	ABC1 family; Region: ABC1; pfam03109
1076934003222	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1076934003223	active site
1076934003224	ATP binding site [chemical binding]; other site
1076934003225	ABC1 family; Region: ABC1; cl17513
1076934003226	Uncharacterized conserved protein [Function unknown]; Region: COG3937
1076934003227	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1076934003228	Helix-turn-helix domain; Region: HTH_18; pfam12833
1076934003229	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1076934003230	HTH-like domain; Region: HTH_21; pfam13276
1076934003231	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1076934003232	Integrase core domain; Region: rve; pfam00665
1076934003233	Integrase core domain; Region: rve_2; pfam13333
1076934003234	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1076934003235	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1076934003236	Cl- selectivity filter; other site
1076934003237	Cl- binding residues [ion binding]; other site
1076934003238	pore gating glutamate residue; other site
1076934003239	dimer interface [polypeptide binding]; other site
1076934003240	H+/Cl- coupling transport residue; other site
1076934003241	TrkA-C domain; Region: TrkA_C; pfam02080
1076934003242	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1076934003243	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1076934003244	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1076934003245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003246	dimer interface [polypeptide binding]; other site
1076934003247	conserved gate region; other site
1076934003248	putative PBP binding loops; other site
1076934003249	ABC-ATPase subunit interface; other site
1076934003250	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1076934003251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003252	dimer interface [polypeptide binding]; other site
1076934003253	conserved gate region; other site
1076934003254	putative PBP binding loops; other site
1076934003255	ABC-ATPase subunit interface; other site
1076934003256	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1076934003257	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1076934003258	Walker A/P-loop; other site
1076934003259	ATP binding site [chemical binding]; other site
1076934003260	Q-loop/lid; other site
1076934003261	ABC transporter signature motif; other site
1076934003262	Walker B; other site
1076934003263	D-loop; other site
1076934003264	H-loop/switch region; other site
1076934003265	TOBE domain; Region: TOBE_2; pfam08402
1076934003266	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1076934003267	FAD binding domain; Region: FAD_binding_4; pfam01565
1076934003268	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1076934003269	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1076934003270	catalytic center binding site [active]
1076934003271	ATP binding site [chemical binding]; other site
1076934003272	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1076934003273	homooctamer interface [polypeptide binding]; other site
1076934003274	active site
1076934003275	dihydropteroate synthase; Region: DHPS; TIGR01496
1076934003276	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1076934003277	substrate binding pocket [chemical binding]; other site
1076934003278	dimer interface [polypeptide binding]; other site
1076934003279	inhibitor binding site; inhibition site
1076934003280	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1076934003281	homodecamer interface [polypeptide binding]; other site
1076934003282	GTP cyclohydrolase I; Provisional; Region: PLN03044
1076934003283	active site
1076934003284	putative catalytic site residues [active]
1076934003285	zinc binding site [ion binding]; other site
1076934003286	GTP-CH-I/GFRP interaction surface; other site
1076934003287	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1076934003288	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1076934003289	rarD protein; Region: rarD; TIGR00688
1076934003290	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1076934003291	homoserine kinase; Provisional; Region: PRK01212
1076934003292	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1076934003293	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1076934003294	homoserine dehydrogenase; Provisional; Region: PRK06349
1076934003295	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1076934003296	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1076934003297	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1076934003298	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1076934003299	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1076934003300	putative active site [active]
1076934003301	putative metal binding site [ion binding]; other site
1076934003302	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1076934003303	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1076934003304	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1076934003305	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1076934003306	core dimer interface [polypeptide binding]; other site
1076934003307	L10 interface [polypeptide binding]; other site
1076934003308	L11 interface [polypeptide binding]; other site
1076934003309	putative EF-Tu interaction site [polypeptide binding]; other site
1076934003310	putative EF-G interaction site [polypeptide binding]; other site
1076934003311	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1076934003312	23S rRNA interface [nucleotide binding]; other site
1076934003313	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1076934003314	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934003315	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934003316	Integrase core domain; Region: rve; pfam00665
1076934003317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934003318	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1076934003319	Walker A motif; other site
1076934003320	ATP binding site [chemical binding]; other site
1076934003321	Walker B motif; other site
1076934003322	arginine finger; other site
1076934003323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934003324	Walker A motif; other site
1076934003325	ATP binding site [chemical binding]; other site
1076934003326	Walker B motif; other site
1076934003327	arginine finger; other site
1076934003328	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1076934003329	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1076934003330	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1076934003331	G1 box; other site
1076934003332	GTP/Mg2+ binding site [chemical binding]; other site
1076934003333	Switch I region; other site
1076934003334	G2 box; other site
1076934003335	G3 box; other site
1076934003336	Switch II region; other site
1076934003337	G4 box; other site
1076934003338	G5 box; other site
1076934003339	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1076934003340	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1076934003341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934003342	Walker A motif; other site
1076934003343	ATP binding site [chemical binding]; other site
1076934003344	Walker B motif; other site
1076934003345	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1076934003346	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1076934003347	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1076934003348	folate binding site [chemical binding]; other site
1076934003349	NADP+ binding site [chemical binding]; other site
1076934003350	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1076934003351	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1076934003352	dimerization interface [polypeptide binding]; other site
1076934003353	active site
1076934003354	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1076934003355	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1076934003356	dimer interface [polypeptide binding]; other site
1076934003357	active site
1076934003358	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1076934003359	homodimer interface [polypeptide binding]; other site
1076934003360	catalytic residues [active]
1076934003361	NAD binding site [chemical binding]; other site
1076934003362	substrate binding pocket [chemical binding]; other site
1076934003363	flexible flap; other site
1076934003364	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1076934003365	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1076934003366	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1076934003367	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1076934003368	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1076934003369	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1076934003370	homotetramer interface [polypeptide binding]; other site
1076934003371	FMN binding site [chemical binding]; other site
1076934003372	homodimer contacts [polypeptide binding]; other site
1076934003373	putative active site [active]
1076934003374	putative substrate binding site [chemical binding]; other site
1076934003375	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
1076934003376	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1076934003377	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1076934003378	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
1076934003379	diphosphomevalonate decarboxylase; Region: PLN02407
1076934003380	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
1076934003381	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1076934003382	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1076934003383	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934003384	Integrase core domain; Region: rve; pfam00665
1076934003385	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1076934003386	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934003387	substrate binding pocket [chemical binding]; other site
1076934003388	membrane-bound complex binding site; other site
1076934003389	hinge residues; other site
1076934003390	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1076934003391	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1076934003392	Walker A/P-loop; other site
1076934003393	ATP binding site [chemical binding]; other site
1076934003394	Q-loop/lid; other site
1076934003395	ABC transporter signature motif; other site
1076934003396	Walker B; other site
1076934003397	D-loop; other site
1076934003398	H-loop/switch region; other site
1076934003399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003400	dimer interface [polypeptide binding]; other site
1076934003401	conserved gate region; other site
1076934003402	putative PBP binding loops; other site
1076934003403	ABC-ATPase subunit interface; other site
1076934003404	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003405	dimer interface [polypeptide binding]; other site
1076934003406	conserved gate region; other site
1076934003407	putative PBP binding loops; other site
1076934003408	ABC-ATPase subunit interface; other site
1076934003409	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1076934003410	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1076934003411	Walker A/P-loop; other site
1076934003412	ATP binding site [chemical binding]; other site
1076934003413	Q-loop/lid; other site
1076934003414	ABC transporter signature motif; other site
1076934003415	Walker B; other site
1076934003416	D-loop; other site
1076934003417	H-loop/switch region; other site
1076934003418	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1076934003419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003420	dimer interface [polypeptide binding]; other site
1076934003421	conserved gate region; other site
1076934003422	putative PBP binding loops; other site
1076934003423	ABC-ATPase subunit interface; other site
1076934003424	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1076934003425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003426	dimer interface [polypeptide binding]; other site
1076934003427	conserved gate region; other site
1076934003428	putative PBP binding loops; other site
1076934003429	ABC-ATPase subunit interface; other site
1076934003430	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934003431	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934003432	substrate binding pocket [chemical binding]; other site
1076934003433	membrane-bound complex binding site; other site
1076934003434	hinge residues; other site
1076934003435	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1076934003436	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1076934003437	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1076934003438	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1076934003439	dimerization interface [polypeptide binding]; other site
1076934003440	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1076934003441	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1076934003442	active site
1076934003443	catalytic tetrad [active]
1076934003444	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1076934003445	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934003446	dimer interface [polypeptide binding]; other site
1076934003447	phosphorylation site [posttranslational modification]
1076934003448	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934003449	ATP binding site [chemical binding]; other site
1076934003450	Mg2+ binding site [ion binding]; other site
1076934003451	G-X-G motif; other site
1076934003452	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934003453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934003454	active site
1076934003455	phosphorylation site [posttranslational modification]
1076934003456	intermolecular recognition site; other site
1076934003457	dimerization interface [polypeptide binding]; other site
1076934003458	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1076934003459	DNA binding site [nucleotide binding]
1076934003460	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1076934003461	synthetase active site [active]
1076934003462	NTP binding site [chemical binding]; other site
1076934003463	metal binding site [ion binding]; metal-binding site
1076934003464	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1076934003465	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1076934003466	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1076934003467	Walker A/P-loop; other site
1076934003468	ATP binding site [chemical binding]; other site
1076934003469	Q-loop/lid; other site
1076934003470	ABC transporter signature motif; other site
1076934003471	Walker B; other site
1076934003472	D-loop; other site
1076934003473	H-loop/switch region; other site
1076934003474	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1076934003475	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1076934003476	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934003477	Walker A/P-loop; other site
1076934003478	ATP binding site [chemical binding]; other site
1076934003479	Q-loop/lid; other site
1076934003480	ABC transporter signature motif; other site
1076934003481	Walker B; other site
1076934003482	D-loop; other site
1076934003483	H-loop/switch region; other site
1076934003484	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1076934003485	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1076934003486	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1076934003487	active site
1076934003488	catalytic residues [active]
1076934003489	metal binding site [ion binding]; metal-binding site
1076934003490	glutamate dehydrogenase; Provisional; Region: PRK09414
1076934003491	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1076934003492	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1076934003493	NAD(P) binding site [chemical binding]; other site
1076934003494	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1076934003495	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1076934003496	active site
1076934003497	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1076934003498	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1076934003499	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1076934003500	Walker A/P-loop; other site
1076934003501	ATP binding site [chemical binding]; other site
1076934003502	Q-loop/lid; other site
1076934003503	ABC transporter signature motif; other site
1076934003504	Walker B; other site
1076934003505	D-loop; other site
1076934003506	H-loop/switch region; other site
1076934003507	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1076934003508	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1076934003509	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934003510	Walker A/P-loop; other site
1076934003511	ATP binding site [chemical binding]; other site
1076934003512	Q-loop/lid; other site
1076934003513	ABC transporter signature motif; other site
1076934003514	Walker B; other site
1076934003515	D-loop; other site
1076934003516	H-loop/switch region; other site
1076934003517	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1076934003518	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934003519	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934003520	ABC transporter; Region: ABC_tran_2; pfam12848
1076934003521	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934003522	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1076934003523	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1076934003524	active site
1076934003525	NTP binding site [chemical binding]; other site
1076934003526	metal binding triad [ion binding]; metal-binding site
1076934003527	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1076934003528	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1076934003529	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1076934003530	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1076934003531	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1076934003532	EDD domain protein, DegV family; Region: DegV; TIGR00762
1076934003533	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1076934003534	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
1076934003535	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1076934003536	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
1076934003537	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1076934003538	TPP-binding site; other site
1076934003539	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1076934003540	PYR/PP interface [polypeptide binding]; other site
1076934003541	dimer interface [polypeptide binding]; other site
1076934003542	TPP binding site [chemical binding]; other site
1076934003543	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1076934003544	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1076934003545	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1076934003546	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1076934003547	FAD binding site [chemical binding]; other site
1076934003548	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1076934003549	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1076934003550	THF binding site; other site
1076934003551	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1076934003552	substrate binding site [chemical binding]; other site
1076934003553	THF binding site; other site
1076934003554	zinc-binding site [ion binding]; other site
1076934003555	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1076934003556	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1076934003557	active site
1076934003558	phosphorylation site [posttranslational modification]
1076934003559	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1076934003560	active site
1076934003561	P-loop; other site
1076934003562	phosphorylation site [posttranslational modification]
1076934003563	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1076934003564	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1076934003565	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1076934003566	putative substrate binding site [chemical binding]; other site
1076934003567	putative ATP binding site [chemical binding]; other site
1076934003568	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1076934003569	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1076934003570	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1076934003571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1076934003572	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1076934003573	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1076934003574	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1076934003575	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1076934003576	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1076934003577	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1076934003578	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1076934003579	RimM N-terminal domain; Region: RimM; pfam01782
1076934003580	PRC-barrel domain; Region: PRC; pfam05239
1076934003581	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1076934003582	KH domain; Region: KH_4; pfam13083
1076934003583	G-X-X-G motif; other site
1076934003584	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
1076934003585	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
1076934003586	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1076934003587	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1076934003588	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1076934003589	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1076934003590	FtsX-like permease family; Region: FtsX; pfam02687
1076934003591	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1076934003592	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1076934003593	Walker A/P-loop; other site
1076934003594	ATP binding site [chemical binding]; other site
1076934003595	Q-loop/lid; other site
1076934003596	ABC transporter signature motif; other site
1076934003597	Walker B; other site
1076934003598	D-loop; other site
1076934003599	H-loop/switch region; other site
1076934003600	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1076934003601	HlyD family secretion protein; Region: HlyD_3; pfam13437
1076934003602	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1076934003603	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1076934003604	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1076934003605	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1076934003606	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1076934003607	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1076934003608	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1076934003609	IMP binding site; other site
1076934003610	dimer interface [polypeptide binding]; other site
1076934003611	interdomain contacts; other site
1076934003612	partial ornithine binding site; other site
1076934003613	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1076934003614	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1076934003615	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1076934003616	catalytic site [active]
1076934003617	subunit interface [polypeptide binding]; other site
1076934003618	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1076934003619	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1076934003620	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1076934003621	uracil transporter; Provisional; Region: PRK10720
1076934003622	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1076934003623	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934003624	active site
1076934003625	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934003626	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934003627	Integrase core domain; Region: rve; pfam00665
1076934003628	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1076934003629	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1076934003630	RNA binding surface [nucleotide binding]; other site
1076934003631	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1076934003632	active site
1076934003633	lipoprotein signal peptidase; Provisional; Region: PRK14797
1076934003634	lipoprotein signal peptidase; Provisional; Region: PRK14787
1076934003635	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1076934003636	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1076934003637	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1076934003638	dimerization interface [polypeptide binding]; other site
1076934003639	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1076934003640	Protein of unknown function (DUF464); Region: DUF464; pfam04327
1076934003641	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1076934003642	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1076934003643	Coenzyme A binding pocket [chemical binding]; other site
1076934003644	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1076934003645	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1076934003646	putative active site [active]
1076934003647	putative metal binding site [ion binding]; other site
1076934003648	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1076934003649	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1076934003650	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1076934003651	Ligand Binding Site [chemical binding]; other site
1076934003652	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1076934003653	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1076934003654	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1076934003655	catalytic residue [active]
1076934003656	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1076934003657	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1076934003658	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1076934003659	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1076934003660	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1076934003661	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1076934003662	NAD binding site [chemical binding]; other site
1076934003663	dimer interface [polypeptide binding]; other site
1076934003664	substrate binding site [chemical binding]; other site
1076934003665	hypothetical protein; Provisional; Region: PRK13676
1076934003666	prephenate dehydrogenase; Validated; Region: PRK06545
1076934003667	prephenate dehydrogenase; Validated; Region: PRK08507
1076934003668	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1076934003669	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1076934003670	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1076934003671	Tetramer interface [polypeptide binding]; other site
1076934003672	active site
1076934003673	FMN-binding site [chemical binding]; other site
1076934003674	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1076934003675	active site
1076934003676	dimer interface [polypeptide binding]; other site
1076934003677	metal binding site [ion binding]; metal-binding site
1076934003678	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1076934003679	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1076934003680	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1076934003681	shikimate binding site; other site
1076934003682	NAD(P) binding site [chemical binding]; other site
1076934003683	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1076934003684	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1076934003685	active site
1076934003686	catalytic residue [active]
1076934003687	dimer interface [polypeptide binding]; other site
1076934003688	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1076934003689	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1076934003690	putative RNA binding site [nucleotide binding]; other site
1076934003691	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1076934003692	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1076934003693	Sulfatase; Region: Sulfatase; pfam00884
1076934003694	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1076934003695	23S rRNA binding site [nucleotide binding]; other site
1076934003696	L21 binding site [polypeptide binding]; other site
1076934003697	L13 binding site [polypeptide binding]; other site
1076934003698	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1076934003699	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1076934003700	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1076934003701	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1076934003702	cytidylate kinase; Provisional; Region: cmk; PRK00023
1076934003703	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1076934003704	CMP-binding site; other site
1076934003705	The sites determining sugar specificity; other site
1076934003706	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1076934003707	peptidase T; Region: peptidase-T; TIGR01882
1076934003708	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1076934003709	metal binding site [ion binding]; metal-binding site
1076934003710	dimer interface [polypeptide binding]; other site
1076934003711	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003712	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003713	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003714	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003715	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003716	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003717	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003718	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1076934003719	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1076934003720	active site
1076934003721	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003722	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003723	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1076934003724	Surface antigen [General function prediction only]; Region: COG3942
1076934003725	CHAP domain; Region: CHAP; pfam05257
1076934003726	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1076934003727	Ligand binding site; other site
1076934003728	Putative Catalytic site; other site
1076934003729	DXD motif; other site
1076934003730	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1076934003731	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1076934003732	Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754
1076934003733	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1076934003734	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1076934003735	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1076934003736	Sulfatase; Region: Sulfatase; pfam00884
1076934003737	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1076934003738	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1076934003739	active site
1076934003740	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1076934003741	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1076934003742	active site
1076934003743	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1076934003744	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1076934003745	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1076934003746	Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066
1076934003747	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1076934003748	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1076934003749	Ligand binding site; other site
1076934003750	Putative Catalytic site; other site
1076934003751	DXD motif; other site
1076934003752	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1076934003753	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1076934003754	active site
1076934003755	Rhamnan synthesis protein F; Region: RgpF; pfam05045
1076934003756	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1076934003757	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1076934003758	active site
1076934003759	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1076934003760	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1076934003761	Walker A/P-loop; other site
1076934003762	ATP binding site [chemical binding]; other site
1076934003763	Q-loop/lid; other site
1076934003764	ABC transporter signature motif; other site
1076934003765	Walker B; other site
1076934003766	D-loop; other site
1076934003767	H-loop/switch region; other site
1076934003768	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1076934003769	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1076934003770	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1076934003771	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
1076934003772	Probable Catalytic site; other site
1076934003773	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
1076934003774	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1076934003775	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1076934003776	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1076934003777	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1076934003778	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1076934003779	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1076934003780	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1076934003781	DNA binding residues [nucleotide binding]
1076934003782	DNA primase; Validated; Region: dnaG; PRK05667
1076934003783	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1076934003784	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1076934003785	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1076934003786	active site
1076934003787	metal binding site [ion binding]; metal-binding site
1076934003788	interdomain interaction site; other site
1076934003789	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1076934003790	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1076934003791	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1076934003792	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934003793	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934003794	Integrase core domain; Region: rve; pfam00665
1076934003795	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934003796	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934003797	substrate binding pocket [chemical binding]; other site
1076934003798	membrane-bound complex binding site; other site
1076934003799	hinge residues; other site
1076934003800	transaminase; Validated; Region: PRK07324
1076934003801	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1076934003802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934003803	homodimer interface [polypeptide binding]; other site
1076934003804	catalytic residue [active]
1076934003805	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934003806	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934003807	substrate binding pocket [chemical binding]; other site
1076934003808	membrane-bound complex binding site; other site
1076934003809	hinge residues; other site
1076934003810	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934003811	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934003812	substrate binding pocket [chemical binding]; other site
1076934003813	membrane-bound complex binding site; other site
1076934003814	hinge residues; other site
1076934003815	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1076934003816	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1076934003817	4-alpha-glucanotransferase; Provisional; Region: PRK14508
1076934003818	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1076934003819	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1076934003820	DNA binding site [nucleotide binding]
1076934003821	domain linker motif; other site
1076934003822	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
1076934003823	putative dimerization interface [polypeptide binding]; other site
1076934003824	putative ligand binding site [chemical binding]; other site
1076934003825	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1076934003826	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1076934003827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003828	dimer interface [polypeptide binding]; other site
1076934003829	conserved gate region; other site
1076934003830	putative PBP binding loops; other site
1076934003831	ABC-ATPase subunit interface; other site
1076934003832	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1076934003833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003834	dimer interface [polypeptide binding]; other site
1076934003835	conserved gate region; other site
1076934003836	putative PBP binding loops; other site
1076934003837	ABC-ATPase subunit interface; other site
1076934003838	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1076934003839	putative active site [active]
1076934003840	nucleotide binding site [chemical binding]; other site
1076934003841	nudix motif; other site
1076934003842	putative metal binding site [ion binding]; other site
1076934003843	excinuclease ABC subunit B; Provisional; Region: PRK05298
1076934003844	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1076934003845	ATP binding site [chemical binding]; other site
1076934003846	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934003847	nucleotide binding region [chemical binding]; other site
1076934003848	ATP-binding site [chemical binding]; other site
1076934003849	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1076934003850	UvrB/uvrC motif; Region: UVR; pfam02151
1076934003851	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934003852	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934003853	substrate binding pocket [chemical binding]; other site
1076934003854	membrane-bound complex binding site; other site
1076934003855	hinge residues; other site
1076934003856	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934003857	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934003858	substrate binding pocket [chemical binding]; other site
1076934003859	membrane-bound complex binding site; other site
1076934003860	hinge residues; other site
1076934003861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934003862	dimer interface [polypeptide binding]; other site
1076934003863	conserved gate region; other site
1076934003864	putative PBP binding loops; other site
1076934003865	ABC-ATPase subunit interface; other site
1076934003866	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1076934003867	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1076934003868	Walker A/P-loop; other site
1076934003869	ATP binding site [chemical binding]; other site
1076934003870	Q-loop/lid; other site
1076934003871	ABC transporter signature motif; other site
1076934003872	Walker B; other site
1076934003873	D-loop; other site
1076934003874	H-loop/switch region; other site
1076934003875	Rubrerythrin [Energy production and conversion]; Region: COG1592
1076934003876	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
1076934003877	binuclear metal center [ion binding]; other site
1076934003878	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
1076934003879	iron binding site [ion binding]; other site
1076934003880	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1076934003881	GTP1/OBG; Region: GTP1_OBG; pfam01018
1076934003882	Obg GTPase; Region: Obg; cd01898
1076934003883	G1 box; other site
1076934003884	GTP/Mg2+ binding site [chemical binding]; other site
1076934003885	Switch I region; other site
1076934003886	G2 box; other site
1076934003887	G3 box; other site
1076934003888	Switch II region; other site
1076934003889	G4 box; other site
1076934003890	G5 box; other site
1076934003891	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1076934003892	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1076934003893	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1076934003894	RNA binding surface [nucleotide binding]; other site
1076934003895	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1076934003896	active site
1076934003897	uracil binding [chemical binding]; other site
1076934003898	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1076934003899	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1076934003900	peptide binding site [polypeptide binding]; other site
1076934003901	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1076934003902	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1076934003903	peptide binding site [polypeptide binding]; other site
1076934003904	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1076934003905	putative transporter; Provisional; Region: PRK11660
1076934003906	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1076934003907	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1076934003908	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1076934003909	nucleoside/Zn binding site; other site
1076934003910	dimer interface [polypeptide binding]; other site
1076934003911	catalytic motif [active]
1076934003912	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1076934003913	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
1076934003914	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1076934003915	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1076934003916	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1076934003917	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934003918	non-specific DNA binding site [nucleotide binding]; other site
1076934003919	salt bridge; other site
1076934003920	sequence-specific DNA binding site [nucleotide binding]; other site
1076934003921	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1076934003922	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1076934003923	metal-binding site [ion binding]
1076934003924	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1076934003925	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1076934003926	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1076934003927	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
1076934003928	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1076934003929	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1076934003930	ligand binding site [chemical binding]; other site
1076934003931	flexible hinge region; other site
1076934003932	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1076934003933	non-specific DNA interactions [nucleotide binding]; other site
1076934003934	DNA binding site [nucleotide binding]
1076934003935	sequence specific DNA binding site [nucleotide binding]; other site
1076934003936	putative cAMP binding site [chemical binding]; other site
1076934003937	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1076934003938	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
1076934003939	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1076934003940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934003941	S-adenosylmethionine binding site [chemical binding]; other site
1076934003942	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1076934003943	prephenate dehydratase; Provisional; Region: PRK11898
1076934003944	Prephenate dehydratase; Region: PDT; pfam00800
1076934003945	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1076934003946	putative L-Phe binding site [chemical binding]; other site
1076934003947	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1076934003948	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1076934003949	ADP binding site [chemical binding]; other site
1076934003950	magnesium binding site [ion binding]; other site
1076934003951	putative shikimate binding site; other site
1076934003952	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1076934003953	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1076934003954	hinge; other site
1076934003955	active site
1076934003956	GTP-binding protein LepA; Provisional; Region: PRK05433
1076934003957	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1076934003958	G1 box; other site
1076934003959	putative GEF interaction site [polypeptide binding]; other site
1076934003960	GTP/Mg2+ binding site [chemical binding]; other site
1076934003961	Switch I region; other site
1076934003962	G2 box; other site
1076934003963	G3 box; other site
1076934003964	Switch II region; other site
1076934003965	G4 box; other site
1076934003966	G5 box; other site
1076934003967	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1076934003968	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1076934003969	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1076934003970	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1076934003971	active site
1076934003972	multimer interface [polypeptide binding]; other site
1076934003973	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1076934003974	YcfA-like protein; Region: YcfA; pfam07927
1076934003975	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758
1076934003976	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
1076934003977	tetramer interface [polypeptide binding]; other site
1076934003978	putative DNA binding site [nucleotide binding]; other site
1076934003979	Ca binding site [ion binding]; other site
1076934003980	Ca binding site [ion binding]; other site
1076934003981	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
1076934003982	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
1076934003983	Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513
1076934003984	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1076934003985	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
1076934003986	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
1076934003987	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1076934003988	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934003989	active site
1076934003990	motif I; other site
1076934003991	motif II; other site
1076934003992	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934003993	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
1076934003994	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1076934003995	active site
1076934003996	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1076934003997	active site 2 [active]
1076934003998	active site 1 [active]
1076934003999	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1076934004000	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1076934004001	FeS/SAM binding site; other site
1076934004002	HemN C-terminal domain; Region: HemN_C; pfam06969
1076934004003	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1076934004004	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1076934004005	active site
1076934004006	substrate binding site [chemical binding]; other site
1076934004007	metal binding site [ion binding]; metal-binding site
1076934004008	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1076934004009	YbbR-like protein; Region: YbbR; pfam07949
1076934004010	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1076934004011	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1076934004012	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1076934004013	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1076934004014	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1076934004015	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1076934004016	catalytic triad [active]
1076934004017	enolase; Provisional; Region: eno; PRK00077
1076934004018	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1076934004019	dimer interface [polypeptide binding]; other site
1076934004020	metal binding site [ion binding]; metal-binding site
1076934004021	substrate binding pocket [chemical binding]; other site
1076934004022	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
1076934004023	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1076934004024	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1076934004025	metal binding site [ion binding]; metal-binding site
1076934004026	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1076934004027	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1076934004028	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1076934004029	substrate binding site [chemical binding]; other site
1076934004030	glutamase interaction surface [polypeptide binding]; other site
1076934004031	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1076934004032	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1076934004033	catalytic residues [active]
1076934004034	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1076934004035	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1076934004036	putative active site [active]
1076934004037	oxyanion strand; other site
1076934004038	catalytic triad [active]
1076934004039	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1076934004040	putative active site pocket [active]
1076934004041	4-fold oligomerization interface [polypeptide binding]; other site
1076934004042	metal binding residues [ion binding]; metal-binding site
1076934004043	3-fold/trimer interface [polypeptide binding]; other site
1076934004044	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1076934004045	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934004046	motif II; other site
1076934004047	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1076934004048	histidinol dehydrogenase; Region: hisD; TIGR00069
1076934004049	NAD binding site [chemical binding]; other site
1076934004050	dimerization interface [polypeptide binding]; other site
1076934004051	product binding site; other site
1076934004052	substrate binding site [chemical binding]; other site
1076934004053	zinc binding site [ion binding]; other site
1076934004054	catalytic residues [active]
1076934004055	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1076934004056	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1076934004057	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
1076934004058	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1076934004059	dimer interface [polypeptide binding]; other site
1076934004060	motif 1; other site
1076934004061	active site
1076934004062	motif 2; other site
1076934004063	motif 3; other site
1076934004064	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1076934004065	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1076934004066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934004067	homodimer interface [polypeptide binding]; other site
1076934004068	catalytic residue [active]
1076934004069	septation ring formation regulator EzrA; Provisional; Region: PRK04778
1076934004070	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1076934004071	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934004072	Mg2+ binding site [ion binding]; other site
1076934004073	G-X-G motif; other site
1076934004074	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1076934004075	anchoring element; other site
1076934004076	dimer interface [polypeptide binding]; other site
1076934004077	ATP binding site [chemical binding]; other site
1076934004078	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1076934004079	active site
1076934004080	putative metal-binding site [ion binding]; other site
1076934004081	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1076934004082	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1076934004083	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934004084	motif II; other site
1076934004085	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1076934004086	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1076934004087	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1076934004088	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
1076934004089	putative Cl- selectivity filter; other site
1076934004090	putative pore gating glutamate residue; other site
1076934004091	hypothetical protein; Provisional; Region: PRK07248
1076934004092	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1076934004093	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1076934004094	FeS assembly protein SufB; Region: sufB; TIGR01980
1076934004095	flavodoxin; Validated; Region: PRK07308
1076934004096	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1076934004097	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1076934004098	active site
1076934004099	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1076934004100	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1076934004101	active site
1076934004102	NAD binding site [chemical binding]; other site
1076934004103	metal binding site [ion binding]; metal-binding site
1076934004104	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1076934004105	DHH family; Region: DHH; pfam01368
1076934004106	DHHA1 domain; Region: DHHA1; pfam02272
1076934004107	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1076934004108	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1076934004109	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1076934004110	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1076934004111	metal binding site [ion binding]; metal-binding site
1076934004112	YodA lipocalin-like domain; Region: YodA; pfam09223
1076934004113	Peptidase family C69; Region: Peptidase_C69; pfam03577
1076934004114	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1076934004115	YcfA-like protein; Region: YcfA; pfam07927
1076934004116	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
1076934004117	Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682
1076934004118	Protein of unknown function (DUF1366); Region: DUF1366; pfam07104
1076934004119	Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895
1076934004120	anthranilate synthase component I; Provisional; Region: PRK13574
1076934004121	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1076934004122	Phage tail protein; Region: Sipho_tail; pfam05709
1076934004123	Phage tail protein; Region: Sipho_tail; cl17486
1076934004124	tape measure domain; Region: tape_meas_nterm; TIGR02675
1076934004125	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
1076934004126	Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691
1076934004127	Minor capsid protein; Region: Minor_capsid_2; pfam11114
1076934004128	Minor capsid protein; Region: Minor_capsid_1; pfam10665
1076934004129	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
1076934004130	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
1076934004131	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
1076934004132	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
1076934004133	Phage terminase large subunit; Region: Terminase_3; cl12054
1076934004134	Terminase-like family; Region: Terminase_6; pfam03237
1076934004135	Terminase small subunit; Region: Terminase_2; pfam03592
1076934004136	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
1076934004137	Prophage antirepressor [Transcription]; Region: COG3617
1076934004138	BRO family, N-terminal domain; Region: Bro-N; smart01040
1076934004139	ORF6C domain; Region: ORF6C; pfam10552
1076934004140	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1076934004141	substrate interaction site [chemical binding]; other site
1076934004142	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1076934004143	generic binding surface I; other site
1076934004144	generic binding surface II; other site
1076934004145	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1076934004146	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1076934004147	Protein of unknown function (DUF1351); Region: DUF1351; pfam07083
1076934004148	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1076934004149	Switch I region; other site
1076934004150	G3 box; other site
1076934004151	Switch II region; other site
1076934004152	ERF superfamily; Region: ERF; pfam04404
1076934004153	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
1076934004154	Helix-turn-helix domain; Region: HTH_36; pfam13730
1076934004155	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934004156	non-specific DNA binding site [nucleotide binding]; other site
1076934004157	salt bridge; other site
1076934004158	sequence-specific DNA binding site [nucleotide binding]; other site
1076934004159	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1076934004160	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934004161	non-specific DNA binding site [nucleotide binding]; other site
1076934004162	salt bridge; other site
1076934004163	sequence-specific DNA binding site [nucleotide binding]; other site
1076934004164	Predicted transcriptional regulator [Transcription]; Region: COG2932
1076934004165	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1076934004166	Catalytic site [active]
1076934004167	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1076934004168	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1076934004169	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1076934004170	catalytic residues [active]
1076934004171	catalytic nucleophile [active]
1076934004172	Presynaptic Site I dimer interface [polypeptide binding]; other site
1076934004173	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1076934004174	Synaptic Flat tetramer interface [polypeptide binding]; other site
1076934004175	Synaptic Site I dimer interface [polypeptide binding]; other site
1076934004176	DNA binding site [nucleotide binding]
1076934004177	Recombinase; Region: Recombinase; pfam07508
1076934004178	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1076934004179	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1076934004180	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1076934004181	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1076934004182	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
1076934004183	dimer interface [polypeptide binding]; other site
1076934004184	phosphate binding site [ion binding]; other site
1076934004185	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1076934004186	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1076934004187	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1076934004188	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1076934004189	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1076934004190	homotrimer interaction site [polypeptide binding]; other site
1076934004191	putative active site [active]
1076934004192	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
1076934004193	active site
1076934004194	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1076934004195	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1076934004196	putative dimer interface [polypeptide binding]; other site
1076934004197	putative anticodon binding site; other site
1076934004198	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1076934004199	homodimer interface [polypeptide binding]; other site
1076934004200	motif 1; other site
1076934004201	motif 2; other site
1076934004202	active site
1076934004203	motif 3; other site
1076934004204	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
1076934004205	aspartate aminotransferase; Provisional; Region: PRK05764
1076934004206	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1076934004207	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934004208	homodimer interface [polypeptide binding]; other site
1076934004209	catalytic residue [active]
1076934004210	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1076934004211	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
1076934004212	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1076934004213	active site
1076934004214	catalytic site [active]
1076934004215	substrate binding site [chemical binding]; other site
1076934004216	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1076934004217	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1076934004218	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1076934004219	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1076934004220	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1076934004221	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1076934004222	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1076934004223	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934004224	Walker A/P-loop; other site
1076934004225	ATP binding site [chemical binding]; other site
1076934004226	Q-loop/lid; other site
1076934004227	ABC transporter signature motif; other site
1076934004228	Walker B; other site
1076934004229	D-loop; other site
1076934004230	H-loop/switch region; other site
1076934004231	PCRF domain; Region: PCRF; pfam03462
1076934004232	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1076934004233	RF-1 domain; Region: RF-1; pfam00472
1076934004234	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1076934004235	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934004236	motif II; other site
1076934004237	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1076934004238	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1076934004239	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1076934004240	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1076934004241	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1076934004242	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1076934004243	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1076934004244	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1076934004245	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1076934004246	Zn2+ binding site [ion binding]; other site
1076934004247	Mg2+ binding site [ion binding]; other site
1076934004248	sugar phosphate phosphatase; Provisional; Region: PRK10513
1076934004249	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934004250	active site
1076934004251	motif I; other site
1076934004252	motif II; other site
1076934004253	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934004254	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1076934004255	FemAB family; Region: FemAB; pfam02388
1076934004256	FemAB family; Region: FemAB; pfam02388
1076934004257	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1076934004258	triosephosphate isomerase; Provisional; Region: PRK14567
1076934004259	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1076934004260	substrate binding site [chemical binding]; other site
1076934004261	dimer interface [polypeptide binding]; other site
1076934004262	catalytic triad [active]
1076934004263	elongation factor Tu; Reviewed; Region: PRK00049
1076934004264	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1076934004265	G1 box; other site
1076934004266	GEF interaction site [polypeptide binding]; other site
1076934004267	GTP/Mg2+ binding site [chemical binding]; other site
1076934004268	Switch I region; other site
1076934004269	G2 box; other site
1076934004270	G3 box; other site
1076934004271	Switch II region; other site
1076934004272	G4 box; other site
1076934004273	G5 box; other site
1076934004274	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1076934004275	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1076934004276	Antibiotic Binding Site [chemical binding]; other site
1076934004277	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1076934004278	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1076934004279	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1076934004280	oligoendopeptidase F; Region: pepF; TIGR00181
1076934004281	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1076934004282	Zn binding site [ion binding]; other site
1076934004283	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1076934004284	catalytic residues [active]
1076934004285	dimer interface [polypeptide binding]; other site
1076934004286	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
1076934004287	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1076934004288	active site
1076934004289	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1076934004290	putative deacylase active site [active]
1076934004291	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1076934004292	catalytic core [active]
1076934004293	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1076934004294	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1076934004295	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934004296	motif II; other site
1076934004297	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1076934004298	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1076934004299	dimer interface [polypeptide binding]; other site
1076934004300	putative anticodon binding site; other site
1076934004301	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1076934004302	motif 1; other site
1076934004303	active site
1076934004304	motif 2; other site
1076934004305	motif 3; other site
1076934004306	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1076934004307	dimer interface [polypeptide binding]; other site
1076934004308	putative tRNA-binding site [nucleotide binding]; other site
1076934004309	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934004310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934004311	active site
1076934004312	phosphorylation site [posttranslational modification]
1076934004313	intermolecular recognition site; other site
1076934004314	dimerization interface [polypeptide binding]; other site
1076934004315	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934004316	DNA binding site [nucleotide binding]
1076934004317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1076934004318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934004319	dimer interface [polypeptide binding]; other site
1076934004320	phosphorylation site [posttranslational modification]
1076934004321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934004322	ATP binding site [chemical binding]; other site
1076934004323	Mg2+ binding site [ion binding]; other site
1076934004324	G-X-G motif; other site
1076934004325	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1076934004326	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1076934004327	Walker A/P-loop; other site
1076934004328	ATP binding site [chemical binding]; other site
1076934004329	Q-loop/lid; other site
1076934004330	ABC transporter signature motif; other site
1076934004331	Walker B; other site
1076934004332	D-loop; other site
1076934004333	H-loop/switch region; other site
1076934004334	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1076934004335	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1076934004336	FtsX-like permease family; Region: FtsX; pfam02687
1076934004337	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1076934004338	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1076934004339	FtsX-like permease family; Region: FtsX; pfam02687
1076934004340	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
1076934004341	Src Homology 3 domain superfamily; Region: SH3; cl17036
1076934004342	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1076934004343	Peptidase family U32; Region: Peptidase_U32; pfam01136
1076934004344	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1076934004345	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
1076934004346	Peptidase family U32; Region: Peptidase_U32; pfam01136
1076934004347	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
1076934004348	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1076934004349	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
1076934004350	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1076934004351	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1076934004352	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1076934004353	Hpr binding site; other site
1076934004354	active site
1076934004355	homohexamer subunit interaction site [polypeptide binding]; other site
1076934004356	PspC domain; Region: PspC; pfam04024
1076934004357	hypothetical protein; Provisional; Region: PRK04351
1076934004358	SprT homologues; Region: SprT; cl01182
1076934004359	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1076934004360	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1076934004361	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1076934004362	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1076934004363	RNA binding site [nucleotide binding]; other site
1076934004364	Predicted permeases [General function prediction only]; Region: COG0701
1076934004365	Predicted membrane protein [Function unknown]; Region: COG3689
1076934004366	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1076934004367	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1076934004368	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1076934004369	P loop; other site
1076934004370	GTP binding site [chemical binding]; other site
1076934004371	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934004372	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1076934004373	active site
1076934004374	motif I; other site
1076934004375	motif II; other site
1076934004376	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934004377	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1076934004378	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1076934004379	active site
1076934004380	motif I; other site
1076934004381	motif II; other site
1076934004382	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934004383	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1076934004384	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1076934004385	Walker A/P-loop; other site
1076934004386	ATP binding site [chemical binding]; other site
1076934004387	Q-loop/lid; other site
1076934004388	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1076934004389	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1076934004390	ABC transporter signature motif; other site
1076934004391	Walker B; other site
1076934004392	D-loop; other site
1076934004393	H-loop/switch region; other site
1076934004394	ribonuclease III; Reviewed; Region: rnc; PRK00102
1076934004395	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1076934004396	dimerization interface [polypeptide binding]; other site
1076934004397	active site
1076934004398	metal binding site [ion binding]; metal-binding site
1076934004399	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1076934004400	dsRNA binding site [nucleotide binding]; other site
1076934004401	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1076934004402	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1076934004403	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1076934004404	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1076934004405	putative active site [active]
1076934004406	heme pocket [chemical binding]; other site
1076934004407	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934004408	dimer interface [polypeptide binding]; other site
1076934004409	phosphorylation site [posttranslational modification]
1076934004410	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934004411	ATP binding site [chemical binding]; other site
1076934004412	Mg2+ binding site [ion binding]; other site
1076934004413	G-X-G motif; other site
1076934004414	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934004415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934004416	active site
1076934004417	phosphorylation site [posttranslational modification]
1076934004418	intermolecular recognition site; other site
1076934004419	dimerization interface [polypeptide binding]; other site
1076934004420	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934004421	DNA binding site [nucleotide binding]
1076934004422	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1076934004423	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1076934004424	Walker A/P-loop; other site
1076934004425	ATP binding site [chemical binding]; other site
1076934004426	Q-loop/lid; other site
1076934004427	ABC transporter signature motif; other site
1076934004428	Walker B; other site
1076934004429	D-loop; other site
1076934004430	H-loop/switch region; other site
1076934004431	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
1076934004432	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934004433	substrate binding pocket [chemical binding]; other site
1076934004434	membrane-bound complex binding site; other site
1076934004435	hinge residues; other site
1076934004436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934004437	dimer interface [polypeptide binding]; other site
1076934004438	conserved gate region; other site
1076934004439	putative PBP binding loops; other site
1076934004440	ABC-ATPase subunit interface; other site
1076934004441	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1076934004442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934004443	dimer interface [polypeptide binding]; other site
1076934004444	conserved gate region; other site
1076934004445	putative PBP binding loops; other site
1076934004446	ABC-ATPase subunit interface; other site
1076934004447	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1076934004448	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1076934004449	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1076934004450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934004451	dimer interface [polypeptide binding]; other site
1076934004452	phosphorylation site [posttranslational modification]
1076934004453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934004454	ATP binding site [chemical binding]; other site
1076934004455	Mg2+ binding site [ion binding]; other site
1076934004456	G-X-G motif; other site
1076934004457	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934004458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934004459	active site
1076934004460	phosphorylation site [posttranslational modification]
1076934004461	intermolecular recognition site; other site
1076934004462	dimerization interface [polypeptide binding]; other site
1076934004463	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934004464	DNA binding site [nucleotide binding]
1076934004465	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1076934004466	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1076934004467	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1076934004468	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1076934004469	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
1076934004470	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1076934004471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1076934004472	myosin-cross-reactive antigen; Provisional; Region: PRK13977
1076934004473	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1076934004474	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1076934004475	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1076934004476	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1076934004477	active site
1076934004478	dimer interface [polypeptide binding]; other site
1076934004479	motif 1; other site
1076934004480	motif 2; other site
1076934004481	motif 3; other site
1076934004482	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1076934004483	anticodon binding site; other site
1076934004484	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1076934004485	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1076934004486	putative ADP-binding pocket [chemical binding]; other site
1076934004487	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1076934004488	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1076934004489	catabolite control protein A; Region: ccpA; TIGR01481
1076934004490	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1076934004491	DNA binding site [nucleotide binding]
1076934004492	domain linker motif; other site
1076934004493	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1076934004494	dimerization interface [polypeptide binding]; other site
1076934004495	effector binding site; other site
1076934004496	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1076934004497	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1076934004498	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1076934004499	active site
1076934004500	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1076934004501	putative NADH binding site [chemical binding]; other site
1076934004502	putative active site [active]
1076934004503	nudix motif; other site
1076934004504	putative metal binding site [ion binding]; other site
1076934004505	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1076934004506	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1076934004507	dimer interface [polypeptide binding]; other site
1076934004508	FMN binding site [chemical binding]; other site
1076934004509	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1076934004510	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1076934004511	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1076934004512	MarR family; Region: MarR_2; cl17246
1076934004513	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1076934004514	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1076934004515	SmpB-tmRNA interface; other site
1076934004516	ribonuclease R; Region: RNase_R; TIGR02063
1076934004517	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1076934004518	RNB domain; Region: RNB; pfam00773
1076934004519	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1076934004520	RNA binding site [nucleotide binding]; other site
1076934004521	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1076934004522	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1076934004523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1076934004524	putative substrate translocation pore; other site
1076934004525	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1076934004526	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1076934004527	CoA-binding site [chemical binding]; other site
1076934004528	ATP-binding [chemical binding]; other site
1076934004529	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1076934004530	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1076934004531	DNA binding site [nucleotide binding]
1076934004532	catalytic residue [active]
1076934004533	H2TH interface [polypeptide binding]; other site
1076934004534	putative catalytic residues [active]
1076934004535	turnover-facilitating residue; other site
1076934004536	intercalation triad [nucleotide binding]; other site
1076934004537	8OG recognition residue [nucleotide binding]; other site
1076934004538	putative reading head residues; other site
1076934004539	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1076934004540	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1076934004541	GTPase Era; Reviewed; Region: era; PRK00089
1076934004542	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1076934004543	G1 box; other site
1076934004544	GTP/Mg2+ binding site [chemical binding]; other site
1076934004545	Switch I region; other site
1076934004546	G2 box; other site
1076934004547	Switch II region; other site
1076934004548	G3 box; other site
1076934004549	G4 box; other site
1076934004550	G5 box; other site
1076934004551	KH domain; Region: KH_2; pfam07650
1076934004552	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1076934004553	metal-binding heat shock protein; Provisional; Region: PRK00016
1076934004554	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1076934004555	PhoH-like protein; Region: PhoH; pfam02562
1076934004556	hypothetical protein; Provisional; Region: PRK13672
1076934004557	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1076934004558	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1076934004559	S1 domain; Region: S1_2; pfam13509
1076934004560	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1076934004561	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1076934004562	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1076934004563	hinge region; other site
1076934004564	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1076934004565	putative nucleotide binding site [chemical binding]; other site
1076934004566	uridine monophosphate binding site [chemical binding]; other site
1076934004567	homohexameric interface [polypeptide binding]; other site
1076934004568	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1076934004569	mRNA/rRNA interface [nucleotide binding]; other site
1076934004570	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1076934004571	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1076934004572	23S rRNA interface [nucleotide binding]; other site
1076934004573	L7/L12 interface [polypeptide binding]; other site
1076934004574	putative thiostrepton binding site; other site
1076934004575	L25 interface [polypeptide binding]; other site
1076934004576	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
1076934004577	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1076934004578	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1076934004579	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1076934004580	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1076934004581	active site
1076934004582	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1076934004583	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1076934004584	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1076934004585	FeoA domain; Region: FeoA; pfam04023
1076934004586	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1076934004587	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1076934004588	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
1076934004589	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1076934004590	dimer interface [polypeptide binding]; other site
1076934004591	ADP-ribose binding site [chemical binding]; other site
1076934004592	active site
1076934004593	nudix motif; other site
1076934004594	metal binding site [ion binding]; metal-binding site
1076934004595	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1076934004596	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1076934004597	Substrate binding site; other site
1076934004598	Mg++ binding site; other site
1076934004599	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1076934004600	active site
1076934004601	substrate binding site [chemical binding]; other site
1076934004602	CoA binding site [chemical binding]; other site
1076934004603	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1076934004604	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1076934004605	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1076934004606	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
1076934004607	classical (c) SDRs; Region: SDR_c; cd05233
1076934004608	NAD(P) binding site [chemical binding]; other site
1076934004609	active site
1076934004610	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
1076934004611	FemAB family; Region: FemAB; pfam02388
1076934004612	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1076934004613	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1076934004614	active site
1076934004615	HIGH motif; other site
1076934004616	KMSKS motif; other site
1076934004617	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1076934004618	tRNA binding surface [nucleotide binding]; other site
1076934004619	anticodon binding site; other site
1076934004620	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1076934004621	dimer interface [polypeptide binding]; other site
1076934004622	putative tRNA-binding site [nucleotide binding]; other site
1076934004623	Predicted integral membrane protein [Function unknown]; Region: COG5658
1076934004624	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1076934004625	SdpI/YhfL protein family; Region: SdpI; pfam13630
1076934004626	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1076934004627	dimerization interface [polypeptide binding]; other site
1076934004628	putative DNA binding site [nucleotide binding]; other site
1076934004629	putative Zn2+ binding site [ion binding]; other site
1076934004630	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1076934004631	active site
1076934004632	putative catalytic site [active]
1076934004633	DNA binding site [nucleotide binding]
1076934004634	putative phosphate binding site [ion binding]; other site
1076934004635	metal binding site A [ion binding]; metal-binding site
1076934004636	AP binding site [nucleotide binding]; other site
1076934004637	metal binding site B [ion binding]; metal-binding site
1076934004638	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1076934004639	ArsC family; Region: ArsC; pfam03960
1076934004640	putative ArsC-like catalytic residues; other site
1076934004641	putative TRX-like catalytic residues [active]
1076934004642	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
1076934004643	putative ligand binding site [chemical binding]; other site
1076934004644	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1076934004645	putative NAD binding site [chemical binding]; other site
1076934004646	putative catalytic site [active]
1076934004647	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1076934004648	L-serine binding site [chemical binding]; other site
1076934004649	ACT domain interface; other site
1076934004650	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
1076934004651	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1076934004652	catalytic residue [active]
1076934004653	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1076934004654	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
1076934004655	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
1076934004656	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1076934004657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934004658	Walker A motif; other site
1076934004659	ATP binding site [chemical binding]; other site
1076934004660	Walker B motif; other site
1076934004661	arginine finger; other site
1076934004662	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934004663	non-specific DNA binding site [nucleotide binding]; other site
1076934004664	salt bridge; other site
1076934004665	sequence-specific DNA binding site [nucleotide binding]; other site
1076934004666	Replication initiation factor; Region: Rep_trans; pfam02486
1076934004667	Antirestriction protein (ArdA); Region: ArdA; pfam07275
1076934004668	TcpE family; Region: TcpE; pfam12648
1076934004669	AAA-like domain; Region: AAA_10; pfam12846
1076934004670	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1076934004671	Haemolysin-III related; Region: HlyIII; cl03831
1076934004672	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1076934004673	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1076934004674	catalytic residue [active]
1076934004675	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1076934004676	NlpC/P60 family; Region: NLPC_P60; pfam00877
1076934004677	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1076934004678	tetracycline resistance determinant leader peptide; Provisional; Region: PRK14751
1076934004679	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
1076934004680	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
1076934004681	G1 box; other site
1076934004682	putative GEF interaction site [polypeptide binding]; other site
1076934004683	GTP/Mg2+ binding site [chemical binding]; other site
1076934004684	Switch I region; other site
1076934004685	G2 box; other site
1076934004686	G3 box; other site
1076934004687	Switch II region; other site
1076934004688	G4 box; other site
1076934004689	G5 box; other site
1076934004690	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
1076934004691	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
1076934004692	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
1076934004693	Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205
1076934004694	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934004695	non-specific DNA binding site [nucleotide binding]; other site
1076934004696	salt bridge; other site
1076934004697	sequence-specific DNA binding site [nucleotide binding]; other site
1076934004698	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1076934004699	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1076934004700	DNA binding residues [nucleotide binding]
1076934004701	Helix-turn-helix domain; Region: HTH_16; pfam12645
1076934004702	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
1076934004703	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
1076934004704	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
1076934004705	Int/Topo IB signature motif; other site
1076934004706	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1076934004707	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1076934004708	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1076934004709	Predicted methyltransferases [General function prediction only]; Region: COG0313
1076934004710	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1076934004711	putative SAM binding site [chemical binding]; other site
1076934004712	putative homodimer interface [polypeptide binding]; other site
1076934004713	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
1076934004714	PSP1 C-terminal conserved region; Region: PSP1; cl00770
1076934004715	DNA polymerase III subunit delta'; Validated; Region: PRK07276
1076934004716	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1076934004717	thymidylate kinase; Validated; Region: tmk; PRK00698
1076934004718	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1076934004719	TMP-binding site; other site
1076934004720	ATP-binding site [chemical binding]; other site
1076934004721	FOG: CBS domain [General function prediction only]; Region: COG0517
1076934004722	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
1076934004723	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
1076934004724	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1076934004725	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1076934004726	TM-ABC transporter signature motif; other site
1076934004727	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1076934004728	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1076934004729	TM-ABC transporter signature motif; other site
1076934004730	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1076934004731	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1076934004732	putative ligand binding site [chemical binding]; other site
1076934004733	hypothetical protein; Provisional; Region: PRK02302
1076934004734	Protein of unknown function (DUF964); Region: DUF964; pfam06133
1076934004735	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1076934004736	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1076934004737	oligomer interface [polypeptide binding]; other site
1076934004738	active site residues [active]
1076934004739	EamA-like transporter family; Region: EamA; pfam00892
1076934004740	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1076934004741	EamA-like transporter family; Region: EamA; pfam00892
1076934004742	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1076934004743	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1076934004744	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1076934004745	dimerization interface [polypeptide binding]; other site
1076934004746	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934004747	active site
1076934004748	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1076934004749	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1076934004750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934004751	homodimer interface [polypeptide binding]; other site
1076934004752	catalytic residue [active]
1076934004753	cystathionine gamma-synthase; Reviewed; Region: PRK07269
1076934004754	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1076934004755	homodimer interface [polypeptide binding]; other site
1076934004756	substrate-cofactor binding pocket; other site
1076934004757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934004758	catalytic residue [active]
1076934004759	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1076934004760	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1076934004761	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1076934004762	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1076934004763	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1076934004764	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1076934004765	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1076934004766	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1076934004767	Walker A/P-loop; other site
1076934004768	ATP binding site [chemical binding]; other site
1076934004769	Q-loop/lid; other site
1076934004770	ABC transporter signature motif; other site
1076934004771	Walker B; other site
1076934004772	D-loop; other site
1076934004773	H-loop/switch region; other site
1076934004774	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1076934004775	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1076934004776	intersubunit interface [polypeptide binding]; other site
1076934004777	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1076934004778	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1076934004779	ABC-ATPase subunit  interface; other site
1076934004780	dimer interface [polypeptide binding]; other site
1076934004781	putative PBP binding regions; other site
1076934004782	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1076934004783	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1076934004784	ABC-ATPase subunit  interface; other site
1076934004785	dimer interface [polypeptide binding]; other site
1076934004786	putative PBP binding regions; other site
1076934004787	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
1076934004788	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
1076934004789	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
1076934004790	hypothetical protein; Validated; Region: PRK02101
1076934004791	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
1076934004792	Bacterial SH3 domain; Region: SH3_3; cl17532
1076934004793	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1076934004794	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1076934004795	DHHA2 domain; Region: DHHA2; pfam02833
1076934004796	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1076934004797	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1076934004798	FeS/SAM binding site; other site
1076934004799	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1076934004800	Domain of unknown function DUF21; Region: DUF21; pfam01595
1076934004801	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1076934004802	Transporter associated domain; Region: CorC_HlyC; smart01091
1076934004803	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1076934004804	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1076934004805	Walker A/P-loop; other site
1076934004806	ATP binding site [chemical binding]; other site
1076934004807	Q-loop/lid; other site
1076934004808	ABC transporter signature motif; other site
1076934004809	Walker B; other site
1076934004810	D-loop; other site
1076934004811	H-loop/switch region; other site
1076934004812	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1076934004813	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1076934004814	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1076934004815	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1076934004816	active site
1076934004817	Predicted membrane protein [Function unknown]; Region: COG3601
1076934004818	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1076934004819	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1076934004820	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1076934004821	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1076934004822	TrkA-N domain; Region: TrkA_N; pfam02254
1076934004823	TrkA-C domain; Region: TrkA_C; pfam02080
1076934004824	TrkA-N domain; Region: TrkA_N; pfam02254
1076934004825	TrkA-C domain; Region: TrkA_C; pfam02080
1076934004826	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1076934004827	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1076934004828	hypothetical protein; Validated; Region: PRK00041
1076934004829	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1076934004830	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1076934004831	RNA binding surface [nucleotide binding]; other site
1076934004832	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1076934004833	active site
1076934004834	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1076934004835	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1076934004836	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
1076934004837	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1076934004838	active site
1076934004839	Int/Topo IB signature motif; other site
1076934004840	catalytic residues [active]
1076934004841	DNA binding site [nucleotide binding]
1076934004842	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1076934004843	FOG: CBS domain [General function prediction only]; Region: COG0517
1076934004844	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1076934004845	active site
1076934004846	metal binding site [ion binding]; metal-binding site
1076934004847	homotetramer interface [polypeptide binding]; other site
1076934004848	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
1076934004849	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1076934004850	active site
1076934004851	dimerization interface [polypeptide binding]; other site
1076934004852	glutamate racemase; Provisional; Region: PRK00865
1076934004853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1076934004854	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1076934004855	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1076934004856	active site
1076934004857	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1076934004858	substrate binding site [chemical binding]; other site
1076934004859	catalytic residues [active]
1076934004860	dimer interface [polypeptide binding]; other site
1076934004861	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1076934004862	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1076934004863	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1076934004864	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1076934004865	Zn2+ binding site [ion binding]; other site
1076934004866	Mg2+ binding site [ion binding]; other site
1076934004867	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1076934004868	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1076934004869	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1076934004870	galactoside permease; Reviewed; Region: lacY; PRK09528
1076934004871	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1076934004872	putative substrate translocation pore; other site
1076934004873	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1076934004874	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1076934004875	substrate binding [chemical binding]; other site
1076934004876	active site
1076934004877	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1076934004878	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1076934004879	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1076934004880	DNA binding site [nucleotide binding]
1076934004881	domain linker motif; other site
1076934004882	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1076934004883	dimerization interface [polypeptide binding]; other site
1076934004884	ligand binding site [chemical binding]; other site
1076934004885	sodium binding site [ion binding]; other site
1076934004886	acylphosphatase; Provisional; Region: PRK14434
1076934004887	OxaA-like protein precursor; Provisional; Region: PRK02463
1076934004888	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1076934004889	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1076934004890	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1076934004891	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1076934004892	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1076934004893	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1076934004894	dimerization interface [polypeptide binding]; other site
1076934004895	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1076934004896	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1076934004897	Coenzyme A binding pocket [chemical binding]; other site
1076934004898	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1076934004899	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1076934004900	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1076934004901	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1076934004902	SWIM zinc finger; Region: SWIM; pfam04434
1076934004903	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1076934004904	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1076934004905	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1076934004906	ATP binding site [chemical binding]; other site
1076934004907	putative Mg++ binding site [ion binding]; other site
1076934004908	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1076934004909	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934004910	nucleotide binding region [chemical binding]; other site
1076934004911	ATP-binding site [chemical binding]; other site
1076934004912	GTP-binding protein Der; Reviewed; Region: PRK00093
1076934004913	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1076934004914	G1 box; other site
1076934004915	GTP/Mg2+ binding site [chemical binding]; other site
1076934004916	Switch I region; other site
1076934004917	G2 box; other site
1076934004918	Switch II region; other site
1076934004919	G3 box; other site
1076934004920	G4 box; other site
1076934004921	G5 box; other site
1076934004922	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1076934004923	G1 box; other site
1076934004924	GTP/Mg2+ binding site [chemical binding]; other site
1076934004925	Switch I region; other site
1076934004926	G2 box; other site
1076934004927	G3 box; other site
1076934004928	Switch II region; other site
1076934004929	G4 box; other site
1076934004930	G5 box; other site
1076934004931	primosomal protein DnaI; Reviewed; Region: PRK08939
1076934004932	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1076934004933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934004934	Walker A motif; other site
1076934004935	ATP binding site [chemical binding]; other site
1076934004936	Walker B motif; other site
1076934004937	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1076934004938	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1076934004939	ATP cone domain; Region: ATP-cone; pfam03477
1076934004940	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1076934004941	HAMP domain; Region: HAMP; pfam00672
1076934004942	dimerization interface [polypeptide binding]; other site
1076934004943	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934004944	dimer interface [polypeptide binding]; other site
1076934004945	phosphorylation site [posttranslational modification]
1076934004946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934004947	ATP binding site [chemical binding]; other site
1076934004948	Mg2+ binding site [ion binding]; other site
1076934004949	G-X-G motif; other site
1076934004950	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934004951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934004952	active site
1076934004953	phosphorylation site [posttranslational modification]
1076934004954	intermolecular recognition site; other site
1076934004955	dimerization interface [polypeptide binding]; other site
1076934004956	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934004957	DNA binding site [nucleotide binding]
1076934004958	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1076934004959	heat shock protein HtpX; Provisional; Region: PRK04897
1076934004960	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1076934004961	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1076934004962	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934004963	S-adenosylmethionine binding site [chemical binding]; other site
1076934004964	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1076934004965	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1076934004966	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1076934004967	TrkA-N domain; Region: TrkA_N; pfam02254
1076934004968	TrkA-C domain; Region: TrkA_C; pfam02080
1076934004969	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1076934004970	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1076934004971	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1076934004972	Walker A/P-loop; other site
1076934004973	ATP binding site [chemical binding]; other site
1076934004974	Q-loop/lid; other site
1076934004975	ABC transporter signature motif; other site
1076934004976	Walker B; other site
1076934004977	D-loop; other site
1076934004978	H-loop/switch region; other site
1076934004979	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1076934004980	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1076934004981	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1076934004982	Walker A/P-loop; other site
1076934004983	ATP binding site [chemical binding]; other site
1076934004984	Q-loop/lid; other site
1076934004985	ABC transporter signature motif; other site
1076934004986	Walker B; other site
1076934004987	D-loop; other site
1076934004988	H-loop/switch region; other site
1076934004989	hypothetical protein; Provisional; Region: PRK13661
1076934004990	serine/threonine transporter SstT; Provisional; Region: PRK13628
1076934004991	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1076934004992	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1076934004993	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1076934004994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934004995	dimer interface [polypeptide binding]; other site
1076934004996	conserved gate region; other site
1076934004997	ABC-ATPase subunit interface; other site
1076934004998	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1076934004999	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1076934005000	Walker A/P-loop; other site
1076934005001	ATP binding site [chemical binding]; other site
1076934005002	Q-loop/lid; other site
1076934005003	ABC transporter signature motif; other site
1076934005004	Walker B; other site
1076934005005	D-loop; other site
1076934005006	H-loop/switch region; other site
1076934005007	NIL domain; Region: NIL; pfam09383
1076934005008	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1076934005009	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1076934005010	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1076934005011	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1076934005012	substrate binding pocket [chemical binding]; other site
1076934005013	membrane-bound complex binding site; other site
1076934005014	hinge residues; other site
1076934005015	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1076934005016	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1076934005017	metal binding site [ion binding]; metal-binding site
1076934005018	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1076934005019	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1076934005020	catalytic triad [active]
1076934005021	hypothetical protein; Provisional; Region: PRK12378
1076934005022	hypothetical protein; Provisional; Region: PRK13670
1076934005023	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1076934005024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934005025	S-adenosylmethionine binding site [chemical binding]; other site
1076934005026	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1076934005027	Isochorismatase family; Region: Isochorismatase; pfam00857
1076934005028	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1076934005029	catalytic triad [active]
1076934005030	conserved cis-peptide bond; other site
1076934005031	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1076934005032	Zn2+ binding site [ion binding]; other site
1076934005033	Mg2+ binding site [ion binding]; other site
1076934005034	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1076934005035	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1076934005036	active site
1076934005037	(T/H)XGH motif; other site
1076934005038	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1076934005039	GTPase YqeH; Provisional; Region: PRK13796
1076934005040	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1076934005041	GTP/Mg2+ binding site [chemical binding]; other site
1076934005042	G4 box; other site
1076934005043	G5 box; other site
1076934005044	G1 box; other site
1076934005045	Switch I region; other site
1076934005046	G2 box; other site
1076934005047	G3 box; other site
1076934005048	Switch II region; other site
1076934005049	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1076934005050	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934005051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1076934005052	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1076934005053	putative substrate translocation pore; other site
1076934005054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1076934005055	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1076934005056	MarR family; Region: MarR_2; pfam12802
1076934005057	EamA-like transporter family; Region: EamA; pfam00892
1076934005058	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1076934005059	EamA-like transporter family; Region: EamA; pfam00892
1076934005060	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1076934005061	EamA-like transporter family; Region: EamA; pfam00892
1076934005062	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1076934005063	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1076934005064	GatB domain; Region: GatB_Yqey; pfam02637
1076934005065	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1076934005066	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1076934005067	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1076934005068	Isochorismatase family; Region: Isochorismatase; pfam00857
1076934005069	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1076934005070	catalytic triad [active]
1076934005071	conserved cis-peptide bond; other site
1076934005072	transcriptional repressor CodY; Validated; Region: PRK04158
1076934005073	CodY GAF-like domain; Region: CodY; pfam06018
1076934005074	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1076934005075	dimerization interface [polypeptide binding]; other site
1076934005076	putative Zn2+ binding site [ion binding]; other site
1076934005077	putative DNA binding site [nucleotide binding]; other site
1076934005078	aminotransferase AlaT; Validated; Region: PRK09265
1076934005079	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1076934005080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1076934005081	homodimer interface [polypeptide binding]; other site
1076934005082	catalytic residue [active]
1076934005083	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
1076934005084	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1076934005085	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1076934005086	putative active site [active]
1076934005087	catalytic site [active]
1076934005088	putative metal binding site [ion binding]; other site
1076934005089	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1076934005090	Ligand Binding Site [chemical binding]; other site
1076934005091	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1076934005092	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934005093	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696
1076934005094	metal binding site [ion binding]; metal-binding site
1076934005095	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1076934005096	active site
1076934005097	homotetramer interface [polypeptide binding]; other site
1076934005098	homodimer interface [polypeptide binding]; other site
1076934005099	Predicted transcriptional regulator [Transcription]; Region: COG3655
1076934005100	sequence-specific DNA binding site [nucleotide binding]; other site
1076934005101	salt bridge; other site
1076934005102	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1076934005103	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1076934005104	generic binding surface II; other site
1076934005105	ssDNA binding site; other site
1076934005106	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1076934005107	ATP binding site [chemical binding]; other site
1076934005108	putative Mg++ binding site [ion binding]; other site
1076934005109	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934005110	nucleotide binding region [chemical binding]; other site
1076934005111	ATP-binding site [chemical binding]; other site
1076934005112	alanine racemase; Reviewed; Region: alr; PRK00053
1076934005113	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1076934005114	active site
1076934005115	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1076934005116	dimer interface [polypeptide binding]; other site
1076934005117	substrate binding site [chemical binding]; other site
1076934005118	catalytic residues [active]
1076934005119	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1076934005120	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
1076934005121	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1076934005122	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
1076934005123	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1076934005124	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1076934005125	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1076934005126	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1076934005127	nucleotide binding region [chemical binding]; other site
1076934005128	ATP-binding site [chemical binding]; other site
1076934005129	SEC-C motif; Region: SEC-C; pfam02810
1076934005130	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1076934005131	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1076934005132	nucleotide binding site [chemical binding]; other site
1076934005133	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1076934005134	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1076934005135	active site turn [active]
1076934005136	phosphorylation site [posttranslational modification]
1076934005137	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1076934005138	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1076934005139	HPr interaction site; other site
1076934005140	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1076934005141	active site
1076934005142	phosphorylation site [posttranslational modification]
1076934005143	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1076934005144	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1076934005145	substrate binding [chemical binding]; other site
1076934005146	active site
1076934005147	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1076934005148	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1076934005149	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1076934005150	DNA binding site [nucleotide binding]
1076934005151	domain linker motif; other site
1076934005152	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1076934005153	dimerization interface [polypeptide binding]; other site
1076934005154	ligand binding site [chemical binding]; other site
1076934005155	sodium binding site [ion binding]; other site
1076934005156	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1076934005157	putative RNA binding site [nucleotide binding]; other site
1076934005158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1076934005159	elongation factor P; Validated; Region: PRK00529
1076934005160	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1076934005161	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1076934005162	RNA binding site [nucleotide binding]; other site
1076934005163	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1076934005164	RNA binding site [nucleotide binding]; other site
1076934005165	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1076934005166	catalytic motif [active]
1076934005167	Zn binding site [ion binding]; other site
1076934005168	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1076934005169	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1076934005170	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1076934005171	active site
1076934005172	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1076934005173	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1076934005174	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1076934005175	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1076934005176	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1076934005177	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1076934005178	Cl binding site [ion binding]; other site
1076934005179	oligomer interface [polypeptide binding]; other site
1076934005180	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
1076934005181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934005182	non-specific DNA binding site [nucleotide binding]; other site
1076934005183	salt bridge; other site
1076934005184	sequence-specific DNA binding site [nucleotide binding]; other site
1076934005185	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1076934005186	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1076934005187	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1076934005188	dimer interface [polypeptide binding]; other site
1076934005189	ssDNA binding site [nucleotide binding]; other site
1076934005190	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1076934005191	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1076934005192	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
1076934005193	catalytic site [active]
1076934005194	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1076934005195	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1076934005196	minor groove reading motif; other site
1076934005197	helix-hairpin-helix signature motif; other site
1076934005198	substrate binding pocket [chemical binding]; other site
1076934005199	active site
1076934005200	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1076934005201	DNA binding and oxoG recognition site [nucleotide binding]
1076934005202	Predicted membrane protein [Function unknown]; Region: COG2323
1076934005203	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
1076934005204	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1076934005205	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1076934005206	catalytic residues [active]
1076934005207	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1076934005208	active site
1076934005209	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1076934005210	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
1076934005211	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1076934005212	dimerization interface [polypeptide binding]; other site
1076934005213	active site
1076934005214	L-aspartate oxidase; Provisional; Region: PRK06175
1076934005215	FAD binding domain; Region: FAD_binding_2; pfam00890
1076934005216	Quinolinate synthetase A protein; Region: NadA; pfam02445
1076934005217	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1076934005218	MutS domain III; Region: MutS_III; pfam05192
1076934005219	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1076934005220	Walker A/P-loop; other site
1076934005221	ATP binding site [chemical binding]; other site
1076934005222	Q-loop/lid; other site
1076934005223	ABC transporter signature motif; other site
1076934005224	Walker B; other site
1076934005225	D-loop; other site
1076934005226	H-loop/switch region; other site
1076934005227	Smr domain; Region: Smr; pfam01713
1076934005228	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1076934005229	Colicin V production protein; Region: Colicin_V; pfam02674
1076934005230	ribonuclease HIII; Provisional; Region: PRK00996
1076934005231	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1076934005232	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1076934005233	RNA/DNA hybrid binding site [nucleotide binding]; other site
1076934005234	active site
1076934005235	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1076934005236	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1076934005237	Catalytic site [active]
1076934005238	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1076934005239	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1076934005240	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1076934005241	AAA domain; Region: AAA_30; pfam13604
1076934005242	Family description; Region: UvrD_C_2; pfam13538
1076934005243	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1076934005244	active site
1076934005245	DNA polymerase IV; Validated; Region: PRK02406
1076934005246	DNA binding site [nucleotide binding]
1076934005247	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1076934005248	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1076934005249	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1076934005250	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1076934005251	Coenzyme A binding pocket [chemical binding]; other site
1076934005252	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1076934005253	Beta-lactamase; Region: Beta-lactamase; pfam00144
1076934005254	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1076934005255	amphipathic channel; other site
1076934005256	Asn-Pro-Ala signature motifs; other site
1076934005257	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
1076934005258	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
1076934005259	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1076934005260	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1076934005261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934005262	dimer interface [polypeptide binding]; other site
1076934005263	phosphorylation site [posttranslational modification]
1076934005264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934005265	ATP binding site [chemical binding]; other site
1076934005266	Mg2+ binding site [ion binding]; other site
1076934005267	G-X-G motif; other site
1076934005268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934005269	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934005270	active site
1076934005271	phosphorylation site [posttranslational modification]
1076934005272	intermolecular recognition site; other site
1076934005273	dimerization interface [polypeptide binding]; other site
1076934005274	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934005275	DNA binding site [nucleotide binding]
1076934005276	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1076934005277	PhoU domain; Region: PhoU; pfam01895
1076934005278	PhoU domain; Region: PhoU; pfam01895
1076934005279	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
1076934005280	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1076934005281	Walker A/P-loop; other site
1076934005282	ATP binding site [chemical binding]; other site
1076934005283	Q-loop/lid; other site
1076934005284	ABC transporter signature motif; other site
1076934005285	Walker B; other site
1076934005286	D-loop; other site
1076934005287	H-loop/switch region; other site
1076934005288	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1076934005289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934005290	dimer interface [polypeptide binding]; other site
1076934005291	conserved gate region; other site
1076934005292	putative PBP binding loops; other site
1076934005293	ABC-ATPase subunit interface; other site
1076934005294	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1076934005295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934005296	dimer interface [polypeptide binding]; other site
1076934005297	conserved gate region; other site
1076934005298	putative PBP binding loops; other site
1076934005299	ABC-ATPase subunit interface; other site
1076934005300	PBP superfamily domain; Region: PBP_like_2; cl17296
1076934005301	PBP superfamily domain; Region: PBP_like_2; cl17296
1076934005302	hypothetical protein; Validated; Region: PRK00153
1076934005303	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1076934005304	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1076934005305	DNA binding residues [nucleotide binding]
1076934005306	dimer interface [polypeptide binding]; other site
1076934005307	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1076934005308	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1076934005309	active site
1076934005310	catalytic site [active]
1076934005311	substrate binding site [chemical binding]; other site
1076934005312	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1076934005313	HI0933-like protein; Region: HI0933_like; pfam03486
1076934005314	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1076934005315	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1076934005316	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1076934005317	UGMP family protein; Validated; Region: PRK09604
1076934005318	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1076934005319	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1076934005320	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1076934005321	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1076934005322	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1076934005323	Coenzyme A binding pocket [chemical binding]; other site
1076934005324	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1076934005325	Glycoprotease family; Region: Peptidase_M22; pfam00814
1076934005326	hypothetical protein; Provisional; Region: PRK13667
1076934005327	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1076934005328	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1076934005329	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1076934005330	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1076934005331	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1076934005332	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1076934005333	NAD binding site [chemical binding]; other site
1076934005334	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1076934005335	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1076934005336	active site
1076934005337	dimer interface [polypeptide binding]; other site
1076934005338	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1076934005339	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1076934005340	active site
1076934005341	FMN binding site [chemical binding]; other site
1076934005342	substrate binding site [chemical binding]; other site
1076934005343	3Fe-4S cluster binding site [ion binding]; other site
1076934005344	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1076934005345	domain interface; other site
1076934005346	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1076934005347	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1076934005348	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1076934005349	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1076934005350	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1076934005351	DNA binding residues [nucleotide binding]
1076934005352	putative dimer interface [polypeptide binding]; other site
1076934005353	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1076934005354	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1076934005355	Phosphoglycerate kinase; Region: PGK; pfam00162
1076934005356	substrate binding site [chemical binding]; other site
1076934005357	hinge regions; other site
1076934005358	ADP binding site [chemical binding]; other site
1076934005359	catalytic site [active]
1076934005360	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1076934005361	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1076934005362	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1076934005363	elongation factor G; Reviewed; Region: PRK00007
1076934005364	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1076934005365	G1 box; other site
1076934005366	putative GEF interaction site [polypeptide binding]; other site
1076934005367	GTP/Mg2+ binding site [chemical binding]; other site
1076934005368	Switch I region; other site
1076934005369	G2 box; other site
1076934005370	G3 box; other site
1076934005371	Switch II region; other site
1076934005372	G4 box; other site
1076934005373	G5 box; other site
1076934005374	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1076934005375	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1076934005376	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1076934005377	30S ribosomal protein S7; Validated; Region: PRK05302
1076934005378	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1076934005379	S17 interaction site [polypeptide binding]; other site
1076934005380	S8 interaction site; other site
1076934005381	16S rRNA interaction site [nucleotide binding]; other site
1076934005382	streptomycin interaction site [chemical binding]; other site
1076934005383	23S rRNA interaction site [nucleotide binding]; other site
1076934005384	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1076934005385	pur operon repressor; Provisional; Region: PRK09213
1076934005386	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1076934005387	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1076934005388	active site
1076934005389	Bacterial lipoprotein; Region: DUF3642; pfam12182
1076934005390	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
1076934005391	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1076934005392	generic binding surface II; other site
1076934005393	generic binding surface I; other site
1076934005394	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1076934005395	Zn2+ binding site [ion binding]; other site
1076934005396	Mg2+ binding site [ion binding]; other site
1076934005397	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
1076934005398	RmuC family; Region: RmuC; pfam02646
1076934005399	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1076934005400	Thiamine pyrophosphokinase; Region: TPK; cd07995
1076934005401	active site
1076934005402	dimerization interface [polypeptide binding]; other site
1076934005403	thiamine binding site [chemical binding]; other site
1076934005404	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1076934005405	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1076934005406	substrate binding site [chemical binding]; other site
1076934005407	hexamer interface [polypeptide binding]; other site
1076934005408	metal binding site [ion binding]; metal-binding site
1076934005409	GTPase RsgA; Reviewed; Region: PRK00098
1076934005410	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1076934005411	RNA binding site [nucleotide binding]; other site
1076934005412	homodimer interface [polypeptide binding]; other site
1076934005413	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1076934005414	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1076934005415	GTP/Mg2+ binding site [chemical binding]; other site
1076934005416	G4 box; other site
1076934005417	G5 box; other site
1076934005418	G1 box; other site
1076934005419	Switch I region; other site
1076934005420	G2 box; other site
1076934005421	G3 box; other site
1076934005422	Switch II region; other site
1076934005423	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1076934005424	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1076934005425	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1076934005426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1076934005427	S-adenosylmethionine binding site [chemical binding]; other site
1076934005428	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1076934005429	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1076934005430	putative active site [active]
1076934005431	putative metal binding site [ion binding]; other site
1076934005432	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1076934005433	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1076934005434	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1076934005435	active site
1076934005436	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1076934005437	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1076934005438	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1076934005439	NAD binding site [chemical binding]; other site
1076934005440	dimer interface [polypeptide binding]; other site
1076934005441	substrate binding site [chemical binding]; other site
1076934005442	CAAX protease self-immunity; Region: Abi; pfam02517
1076934005443	putative transposase OrfB; Reviewed; Region: PHA02517
1076934005444	Integrase core domain; Region: rve; pfam00665
1076934005445	Integrase core domain; Region: rve_3; pfam13683
1076934005446	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1076934005447	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1076934005448	ABC-ATPase subunit  interface; other site
1076934005449	dimer interface [polypeptide binding]; other site
1076934005450	putative PBP binding regions; other site
1076934005451	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1076934005452	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1076934005453	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1076934005454	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1076934005455	metal binding site [ion binding]; metal-binding site
1076934005456	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1076934005457	malate dehydrogenase; Provisional; Region: PRK13529
1076934005458	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1076934005459	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1076934005460	NAD(P) binding site [chemical binding]; other site
1076934005461	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1076934005462	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1076934005463	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1076934005464	dimerization interface [polypeptide binding]; other site
1076934005465	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1076934005466	DltD N-terminal region; Region: DltD_N; pfam04915
1076934005467	DltD central region; Region: DltD_M; pfam04918
1076934005468	DltD C-terminal region; Region: DltD_C; pfam04914
1076934005469	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1076934005470	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1076934005471	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1076934005472	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1076934005473	acyl-activating enzyme (AAE) consensus motif; other site
1076934005474	AMP binding site [chemical binding]; other site
1076934005475	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
1076934005476	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1076934005477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1076934005478	dimer interface [polypeptide binding]; other site
1076934005479	phosphorylation site [posttranslational modification]
1076934005480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934005481	ATP binding site [chemical binding]; other site
1076934005482	Mg2+ binding site [ion binding]; other site
1076934005483	G-X-G motif; other site
1076934005484	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1076934005485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1076934005486	intermolecular recognition site; other site
1076934005487	active site
1076934005488	dimerization interface [polypeptide binding]; other site
1076934005489	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1076934005490	DNA binding site [nucleotide binding]
1076934005491	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1076934005492	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1076934005493	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
1076934005494	active site
1076934005495	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1076934005496	active site
1076934005497	catalytic residues [active]
1076934005498	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1076934005499	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934005500	dimer interface [polypeptide binding]; other site
1076934005501	conserved gate region; other site
1076934005502	putative PBP binding loops; other site
1076934005503	ABC-ATPase subunit interface; other site
1076934005504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1076934005505	dimer interface [polypeptide binding]; other site
1076934005506	conserved gate region; other site
1076934005507	putative PBP binding loops; other site
1076934005508	ABC-ATPase subunit interface; other site
1076934005509	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1076934005510	N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749
1076934005511	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
1076934005512	catalytic domain interface [polypeptide binding]; other site
1076934005513	putative homodimer interface [polypeptide binding]; other site
1076934005514	Protein of unknown function, DUF608; Region: DUF608; pfam04685
1076934005515	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
1076934005516	active site
1076934005517	catalytic residues [active]
1076934005518	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
1076934005519	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1076934005520	LytTr DNA-binding domain; Region: LytTR; smart00850
1076934005521	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1076934005522	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1076934005523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934005524	Walker A/P-loop; other site
1076934005525	ATP binding site [chemical binding]; other site
1076934005526	Q-loop/lid; other site
1076934005527	ABC transporter signature motif; other site
1076934005528	Walker B; other site
1076934005529	D-loop; other site
1076934005530	H-loop/switch region; other site
1076934005531	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1076934005532	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1076934005533	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1076934005534	G-X-X-G motif; other site
1076934005535	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1076934005536	RxxxH motif; other site
1076934005537	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1076934005538	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1076934005539	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1076934005540	argininosuccinate lyase; Provisional; Region: PRK00855
1076934005541	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1076934005542	active sites [active]
1076934005543	tetramer interface [polypeptide binding]; other site
1076934005544	argininosuccinate synthase; Provisional; Region: PRK13820
1076934005545	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1076934005546	ANP binding site [chemical binding]; other site
1076934005547	Substrate Binding Site II [chemical binding]; other site
1076934005548	Substrate Binding Site I [chemical binding]; other site
1076934005549	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1076934005550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1076934005551	putative substrate translocation pore; other site
1076934005552	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1076934005553	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1076934005554	active site
1076934005555	HIGH motif; other site
1076934005556	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1076934005557	active site
1076934005558	KMSKS motif; other site
1076934005559	Tubby C 2; Region: Tub_2; cl02043
1076934005560	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1076934005561	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1076934005562	active site
1076934005563	catalytic tetrad [active]
1076934005564	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1076934005565	active site clefts [active]
1076934005566	zinc binding site [ion binding]; other site
1076934005567	dimer interface [polypeptide binding]; other site
1076934005568	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1076934005569	Walker A motif; other site
1076934005570	ATP binding site [chemical binding]; other site
1076934005571	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1076934005572	Walker B motif; other site
1076934005573	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1076934005574	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1076934005575	trimer interface [polypeptide binding]; other site
1076934005576	active site
1076934005577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1076934005578	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1076934005579	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1076934005580	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1076934005581	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1076934005582	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1076934005583	active site
1076934005584	tetramer interface; other site
1076934005585	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1076934005586	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1076934005587	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1076934005588	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1076934005589	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1076934005590	metal binding site [ion binding]; metal-binding site
1076934005591	putative dimer interface [polypeptide binding]; other site
1076934005592	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1076934005593	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1076934005594	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1076934005595	trimer interface [polypeptide binding]; other site
1076934005596	active site
1076934005597	substrate binding site [chemical binding]; other site
1076934005598	CoA binding site [chemical binding]; other site
1076934005599	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1076934005600	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1076934005601	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1076934005602	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1076934005603	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1076934005604	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1076934005605	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1076934005606	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1076934005607	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1076934005608	active site
1076934005609	dimer interface [polypeptide binding]; other site
1076934005610	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1076934005611	dimer interface [polypeptide binding]; other site
1076934005612	active site
1076934005613	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1076934005614	nucleoside/Zn binding site; other site
1076934005615	dimer interface [polypeptide binding]; other site
1076934005616	catalytic motif [active]
1076934005617	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1076934005618	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
1076934005619	CHY zinc finger; Region: zf-CHY; pfam05495
1076934005620	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1076934005621	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1076934005622	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1076934005623	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1076934005624	Protein of unknown function (DUF975); Region: DUF975; pfam06161
1076934005625	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1076934005626	metal binding site 2 [ion binding]; metal-binding site
1076934005627	putative DNA binding helix; other site
1076934005628	metal binding site 1 [ion binding]; metal-binding site
1076934005629	dimer interface [polypeptide binding]; other site
1076934005630	structural Zn2+ binding site [ion binding]; other site
1076934005631	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1076934005632	DNA polymerase I; Provisional; Region: PRK05755
1076934005633	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1076934005634	active site
1076934005635	metal binding site 1 [ion binding]; metal-binding site
1076934005636	putative 5' ssDNA interaction site; other site
1076934005637	metal binding site 3; metal-binding site
1076934005638	metal binding site 2 [ion binding]; metal-binding site
1076934005639	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1076934005640	putative DNA binding site [nucleotide binding]; other site
1076934005641	putative metal binding site [ion binding]; other site
1076934005642	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1076934005643	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1076934005644	active site
1076934005645	DNA binding site [nucleotide binding]
1076934005646	catalytic site [active]
1076934005647	Membrane transport protein; Region: Mem_trans; pfam03547
1076934005648	Uncharacterized membrane protein [Function unknown]; Region: COG3949
1076934005649	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1076934005650	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1076934005651	GDP-binding site [chemical binding]; other site
1076934005652	ACT binding site; other site
1076934005653	IMP binding site; other site
1076934005654	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
1076934005655	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
1076934005656	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1076934005657	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
1076934005658	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1076934005659	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1076934005660	dimerization interface [polypeptide binding]; other site
1076934005661	domain crossover interface; other site
1076934005662	redox-dependent activation switch; other site
1076934005663	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1076934005664	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1076934005665	FMN binding site [chemical binding]; other site
1076934005666	active site
1076934005667	catalytic residues [active]
1076934005668	substrate binding site [chemical binding]; other site
1076934005669	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1076934005670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934005671	Walker A motif; other site
1076934005672	ATP binding site [chemical binding]; other site
1076934005673	Walker B motif; other site
1076934005674	arginine finger; other site
1076934005675	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1076934005676	Walker A motif; other site
1076934005677	ATP binding site [chemical binding]; other site
1076934005678	Walker B motif; other site
1076934005679	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1076934005680	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1076934005681	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
1076934005682	elongation factor Ts; Provisional; Region: tsf; PRK09377
1076934005683	UBA/TS-N domain; Region: UBA; pfam00627
1076934005684	Elongation factor TS; Region: EF_TS; pfam00889
1076934005685	Elongation factor TS; Region: EF_TS; pfam00889
1076934005686	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1076934005687	rRNA interaction site [nucleotide binding]; other site
1076934005688	S8 interaction site; other site
1076934005689	putative laminin-1 binding site; other site
1076934005690	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1076934005691	putative dimer interface [polypeptide binding]; other site
1076934005692	catalytic triad [active]
1076934005693	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934005694	non-specific DNA binding site [nucleotide binding]; other site
1076934005695	salt bridge; other site
1076934005696	sequence-specific DNA binding site [nucleotide binding]; other site
1076934005697	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1076934005698	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1076934005699	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1076934005700	active site
1076934005701	Zn binding site [ion binding]; other site
1076934005702	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1076934005703	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1076934005704	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1076934005705	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1076934005706	FeS/SAM binding site; other site
1076934005707	Predicted acetyltransferase [General function prediction only]; Region: COG3981
1076934005708	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1076934005709	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1076934005710	ATP cone domain; Region: ATP-cone; pfam03477
1076934005711	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1076934005712	effector binding site; other site
1076934005713	active site
1076934005714	Zn binding site [ion binding]; other site
1076934005715	glycine loop; other site
1076934005716	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
1076934005717	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1076934005718	hypothetical protein; Provisional; Region: PRK13678
1076934005719	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1076934005720	hypothetical protein; Provisional; Region: PRK05473
1076934005721	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1076934005722	ArsC family; Region: ArsC; pfam03960
1076934005723	putative catalytic residues [active]
1076934005724	thiol/disulfide switch; other site
1076934005725	recombinase A; Provisional; Region: recA; PRK09354
1076934005726	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1076934005727	hexamer interface [polypeptide binding]; other site
1076934005728	Walker A motif; other site
1076934005729	ATP binding site [chemical binding]; other site
1076934005730	Walker B motif; other site
1076934005731	competence damage-inducible protein A; Provisional; Region: PRK00549
1076934005732	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1076934005733	putative MPT binding site; other site
1076934005734	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1076934005735	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1076934005736	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1076934005737	RuvA N terminal domain; Region: RuvA_N; pfam01330
1076934005738	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1076934005739	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1076934005740	ATP binding site [chemical binding]; other site
1076934005741	Mg2+ binding site [ion binding]; other site
1076934005742	G-X-G motif; other site
1076934005743	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1076934005744	ATP binding site [chemical binding]; other site
1076934005745	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1076934005746	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1076934005747	MutS domain I; Region: MutS_I; pfam01624
1076934005748	MutS domain II; Region: MutS_II; pfam05188
1076934005749	MutS domain III; Region: MutS_III; pfam05192
1076934005750	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1076934005751	Walker A/P-loop; other site
1076934005752	ATP binding site [chemical binding]; other site
1076934005753	Q-loop/lid; other site
1076934005754	ABC transporter signature motif; other site
1076934005755	Walker B; other site
1076934005756	D-loop; other site
1076934005757	H-loop/switch region; other site
1076934005758	Protein of unknown function (DUF964); Region: DUF964; cl01483
1076934005759	Arginine repressor [Transcription]; Region: ArgR; COG1438
1076934005760	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1076934005761	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1076934005762	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1076934005763	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1076934005764	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1076934005765	active site
1076934005766	HIGH motif; other site
1076934005767	KMSK motif region; other site
1076934005768	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1076934005769	tRNA binding surface [nucleotide binding]; other site
1076934005770	anticodon binding site; other site
1076934005771	Predicted peptidase [General function prediction only]; Region: COG4099
1076934005772	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1076934005773	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1076934005774	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1076934005775	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1076934005776	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1076934005777	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1076934005778	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1076934005779	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1076934005780	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1076934005781	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1076934005782	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1076934005783	dimer interface [polypeptide binding]; other site
1076934005784	anticodon binding site; other site
1076934005785	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1076934005786	homodimer interface [polypeptide binding]; other site
1076934005787	motif 1; other site
1076934005788	active site
1076934005789	motif 2; other site
1076934005790	GAD domain; Region: GAD; pfam02938
1076934005791	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1076934005792	motif 3; other site
1076934005793	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1076934005794	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1076934005795	dimer interface [polypeptide binding]; other site
1076934005796	motif 1; other site
1076934005797	active site
1076934005798	motif 2; other site
1076934005799	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1076934005800	anticodon binding site; other site
1076934005801	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1076934005802	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1076934005803	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
1076934005804	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
1076934005805	Int/Topo IB signature motif; other site
1076934005806	Replication initiation factor; Region: Rep_trans; pfam02486
1076934005807	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1076934005808	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934005809	non-specific DNA binding site [nucleotide binding]; other site
1076934005810	salt bridge; other site
1076934005811	sequence-specific DNA binding site [nucleotide binding]; other site
1076934005812	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1076934005813	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1076934005814	Predicted membrane protein [Function unknown]; Region: COG1808
1076934005815	Predicted membrane protein [Function unknown]; Region: COG2261
1076934005816	Small integral membrane protein [Function unknown]; Region: COG5547
1076934005817	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1076934005818	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1076934005819	Predicted membrane protein [Function unknown]; Region: COG1511
1076934005820	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1076934005821	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1076934005822	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1076934005823	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1076934005824	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934005825	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934005826	Integrase core domain; Region: rve; pfam00665
1076934005827	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1076934005828	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1076934005829	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1076934005830	RNA binding surface [nucleotide binding]; other site
1076934005831	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
1076934005832	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1076934005833	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
1076934005834	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1076934005835	Walker A motif; other site
1076934005836	ATP binding site [chemical binding]; other site
1076934005837	Walker B motif; other site
1076934005838	DNA binding loops [nucleotide binding]
1076934005839	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1076934005840	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1076934005841	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1076934005842	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1076934005843	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1076934005844	DHH family; Region: DHH; pfam01368
1076934005845	DHHA1 domain; Region: DHHA1; pfam02272
1076934005846	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1076934005847	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1076934005848	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1076934005849	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1076934005850	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1076934005851	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1076934005852	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1076934005853	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1076934005854	putative L-serine binding site [chemical binding]; other site
1076934005855	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1076934005856	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1076934005857	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1076934005858	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1076934005859	motif II; other site
1076934005860	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1076934005861	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1076934005862	catalytic residue [active]
1076934005863	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1076934005864	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1076934005865	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1076934005866	Int/Topo IB signature motif; other site
1076934005867	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1076934005868	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1076934005869	non-specific DNA binding site [nucleotide binding]; other site
1076934005870	salt bridge; other site
1076934005871	sequence-specific DNA binding site [nucleotide binding]; other site
1076934005872	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1076934005873	BRO family, N-terminal domain; Region: Bro-N; cl10591
1076934005874	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
1076934005875	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1076934005876	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
1076934005877	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934005878	Integrase core domain; Region: rve; pfam00665
1076934005879	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934005880	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1076934005881	Helix-turn-helix domain; Region: HTH_38; pfam13936
1076934005882	Integrase core domain; Region: rve; pfam00665
1076934005883	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1076934005884	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1076934005885	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
1076934005886	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1076934005887	Walker A/P-loop; other site
1076934005888	ATP binding site [chemical binding]; other site
1076934005889	Q-loop/lid; other site
1076934005890	ABC transporter signature motif; other site
1076934005891	Walker B; other site
1076934005892	D-loop; other site
1076934005893	H-loop/switch region; other site
1076934005894	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
1076934005895	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1076934005896	Walker A/P-loop; other site
1076934005897	ATP binding site [chemical binding]; other site
1076934005898	Q-loop/lid; other site
1076934005899	ABC transporter signature motif; other site
1076934005900	Walker B; other site
1076934005901	D-loop; other site
1076934005902	H-loop/switch region; other site
1076934005903	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1076934005904	Helix-turn-helix domain; Region: HTH_25; pfam13413
1076934005905	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1076934005906	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1076934005907	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1076934005908	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1076934005909	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1076934005910	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1076934005911	recombination protein F; Reviewed; Region: recF; PRK00064
1076934005912	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1076934005913	Walker A/P-loop; other site
1076934005914	ATP binding site [chemical binding]; other site
1076934005915	Q-loop/lid; other site
1076934005916	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1076934005917	ABC transporter signature motif; other site
1076934005918	Walker B; other site
1076934005919	D-loop; other site
1076934005920	H-loop/switch region; other site
1076934005921	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
1076934005922	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1076934005923	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1076934005924	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1076934005925	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1076934005926	active site
1076934005927	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1076934005928	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1076934005929	active site
1076934005930	HIGH motif; other site
1076934005931	dimer interface [polypeptide binding]; other site
1076934005932	KMSKS motif; other site
1076934005933	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1076934005934	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1076934005935	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1076934005936	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1076934005937	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1076934005938	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934005939	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934005940	ABC transporter; Region: ABC_tran_2; pfam12848
1076934005941	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1076934005942	Predicted membrane protein [Function unknown]; Region: COG4485
1076934005943	HTH-like domain; Region: HTH_21; pfam13276
1076934005944	Integrase core domain; Region: rve; pfam00665
1076934005945	Integrase core domain; Region: rve_2; pfam13333
1076934005946	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1076934005947	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1076934005948	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1076934005949	protein binding site [polypeptide binding]; other site
1076934005950	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1076934005951	ParB-like nuclease domain; Region: ParBc; pfam02195