-- dump date 20140620_080159 -- class Genbank::misc_feature -- table misc_feature_note -- id note 937773000001 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 937773000002 ribonuclease P; Reviewed; Region: rnpA; PRK00499 937773000003 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 937773000004 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 937773000005 trmE is a tRNA modification GTPase; Region: trmE; cd04164 937773000006 G1 box; other site 937773000007 GTP/Mg2+ binding site [chemical binding]; other site 937773000008 Switch I region; other site 937773000009 G2 box; other site 937773000010 Switch II region; other site 937773000011 G3 box; other site 937773000012 G4 box; other site 937773000013 G5 box; other site 937773000014 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 937773000015 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 937773000016 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 937773000017 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 937773000018 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 937773000019 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 937773000020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773000021 S-adenosylmethionine binding site [chemical binding]; other site 937773000022 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 937773000023 ParB-like nuclease domain; Region: ParBc; pfam02195 937773000024 Predicted esterase [General function prediction only]; Region: COG0400 937773000025 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 937773000026 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 937773000027 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 937773000028 Zn binding site [ion binding]; other site 937773000029 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 937773000030 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 937773000031 Zn binding site [ion binding]; other site 937773000032 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773000033 MarR family; Region: MarR; pfam01047 937773000034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 937773000035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773000036 Coenzyme A binding pocket [chemical binding]; other site 937773000037 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 937773000038 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 937773000039 dimer interface [polypeptide binding]; other site 937773000040 catalytic residues [active] 937773000041 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 937773000042 UreF; Region: UreF; pfam01730 937773000043 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 937773000044 UreD urease accessory protein; Region: UreD; cl00530 937773000045 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 937773000046 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 937773000047 THF binding site; other site 937773000048 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 937773000049 substrate binding site [chemical binding]; other site 937773000050 THF binding site; other site 937773000051 zinc-binding site [ion binding]; other site 937773000052 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 937773000053 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 937773000054 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 937773000055 FAD binding site [chemical binding]; other site 937773000056 cystathionine beta-lyase; Provisional; Region: PRK08064 937773000057 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 937773000058 homodimer interface [polypeptide binding]; other site 937773000059 substrate-cofactor binding pocket; other site 937773000060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000061 catalytic residue [active] 937773000062 cystathionine gamma-synthase; Reviewed; Region: PRK08247 937773000063 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773000064 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773000065 catalytic residue [active] 937773000066 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 937773000067 ParB-like nuclease domain; Region: ParB; smart00470 937773000068 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 937773000069 Mechanosensitive ion channel; Region: MS_channel; pfam00924 937773000070 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 937773000071 GTP-binding protein YchF; Reviewed; Region: PRK09601 937773000072 YchF GTPase; Region: YchF; cd01900 937773000073 G1 box; other site 937773000074 GTP/Mg2+ binding site [chemical binding]; other site 937773000075 Switch I region; other site 937773000076 G2 box; other site 937773000077 Switch II region; other site 937773000078 G3 box; other site 937773000079 G4 box; other site 937773000080 G5 box; other site 937773000081 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 937773000082 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 937773000083 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 937773000084 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 937773000085 Walker A/P-loop; other site 937773000086 ATP binding site [chemical binding]; other site 937773000087 Q-loop/lid; other site 937773000088 ABC transporter signature motif; other site 937773000089 Walker B; other site 937773000090 D-loop; other site 937773000091 H-loop/switch region; other site 937773000092 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 937773000093 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 937773000094 B domain; Region: B; pfam02216 937773000095 B domain; Region: B; pfam02216 937773000096 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 937773000097 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 937773000098 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 937773000099 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 937773000100 dimer interface [polypeptide binding]; other site 937773000101 ssDNA binding site [nucleotide binding]; other site 937773000102 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773000103 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 937773000104 Abi-like protein; Region: Abi_2; pfam07751 937773000105 hydroperoxidase II; Provisional; Region: katE; PRK11249 937773000106 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 937773000107 heme binding pocket [chemical binding]; other site 937773000108 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 937773000109 conserved cys residue [active] 937773000110 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 937773000111 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 937773000112 active site 937773000113 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 937773000114 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 937773000115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773000116 dimer interface [polypeptide binding]; other site 937773000117 conserved gate region; other site 937773000118 ABC-ATPase subunit interface; other site 937773000119 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 937773000120 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 937773000121 Walker A/P-loop; other site 937773000122 ATP binding site [chemical binding]; other site 937773000123 Q-loop/lid; other site 937773000124 ABC transporter signature motif; other site 937773000125 Walker B; other site 937773000126 D-loop; other site 937773000127 H-loop/switch region; other site 937773000128 NIL domain; Region: NIL; pfam09383 937773000129 Domain of unknown function (DU1801); Region: DUF1801; cl17490 937773000130 biotin synthase; Validated; Region: PRK06256 937773000131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773000132 FeS/SAM binding site; other site 937773000133 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 937773000134 Predicted secreted protein [Function unknown]; Region: COG4086 937773000135 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 937773000136 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 937773000137 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 937773000138 catalytic residue [active] 937773000139 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 937773000140 catalytic residues [active] 937773000141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 937773000142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773000143 peroxiredoxin; Region: AhpC; TIGR03137 937773000144 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 937773000145 dimer interface [polypeptide binding]; other site 937773000146 decamer (pentamer of dimers) interface [polypeptide binding]; other site 937773000147 catalytic triad [active] 937773000148 peroxidatic and resolving cysteines [active] 937773000149 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 937773000150 dimer interface [polypeptide binding]; other site 937773000151 FMN binding site [chemical binding]; other site 937773000152 NADPH bind site [chemical binding]; other site 937773000153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 937773000154 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 937773000155 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 937773000156 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 937773000157 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 937773000158 Walker A/P-loop; other site 937773000159 ATP binding site [chemical binding]; other site 937773000160 Q-loop/lid; other site 937773000161 ABC transporter signature motif; other site 937773000162 Walker B; other site 937773000163 D-loop; other site 937773000164 H-loop/switch region; other site 937773000165 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 937773000166 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 937773000167 hydroxyglutarate oxidase; Provisional; Region: PRK11728 937773000168 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 937773000169 Heat induced stress protein YflT; Region: YflT; pfam11181 937773000170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773000171 active site 937773000172 xanthine permease; Region: pbuX; TIGR03173 937773000173 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 937773000174 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 937773000175 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 937773000176 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 937773000177 active site 937773000178 GMP synthase; Reviewed; Region: guaA; PRK00074 937773000179 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 937773000180 AMP/PPi binding site [chemical binding]; other site 937773000181 candidate oxyanion hole; other site 937773000182 catalytic triad [active] 937773000183 potential glutamine specificity residues [chemical binding]; other site 937773000184 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 937773000185 ATP Binding subdomain [chemical binding]; other site 937773000186 Ligand Binding sites [chemical binding]; other site 937773000187 Dimerization subdomain; other site 937773000188 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 937773000189 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 937773000190 Int/Topo IB signature motif; other site 937773000191 Terminase small subunit; Region: Terminase_2; cl01513 937773000192 potential frameshift: common BLAST hit: gi|227811479|ref|YP_002811490.1| Abi-like protein 937773000193 Abi-like protein; Region: Abi_2; cl01988 937773000194 Abi-like protein; Region: Abi_2; cl01988 937773000195 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 937773000196 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 937773000197 gating phenylalanine in ion channel; other site 937773000198 Staphylococcal nuclease homologues; Region: SNc; smart00318 937773000199 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 937773000200 Catalytic site; other site 937773000201 Excalibur calcium-binding domain; Region: Excalibur; smart00894 937773000202 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773000203 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773000204 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 937773000205 PGAP1-like protein; Region: PGAP1; pfam07819 937773000206 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 937773000207 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 937773000208 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 937773000209 catalytic triad [active] 937773000210 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 937773000211 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 937773000212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 937773000213 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 937773000214 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 937773000215 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 937773000216 substrate binding site [chemical binding]; other site 937773000217 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 937773000218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773000219 dimer interface [polypeptide binding]; other site 937773000220 conserved gate region; other site 937773000221 putative PBP binding loops; other site 937773000222 ABC-ATPase subunit interface; other site 937773000223 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 937773000224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773000225 dimer interface [polypeptide binding]; other site 937773000226 conserved gate region; other site 937773000227 putative PBP binding loops; other site 937773000228 ABC-ATPase subunit interface; other site 937773000229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 937773000230 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 937773000231 Walker A/P-loop; other site 937773000232 ATP binding site [chemical binding]; other site 937773000233 Q-loop/lid; other site 937773000234 ABC transporter signature motif; other site 937773000235 Walker B; other site 937773000236 D-loop; other site 937773000237 H-loop/switch region; other site 937773000238 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 937773000239 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 937773000240 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 937773000241 Walker A/P-loop; other site 937773000242 ATP binding site [chemical binding]; other site 937773000243 Q-loop/lid; other site 937773000244 ABC transporter signature motif; other site 937773000245 Walker B; other site 937773000246 D-loop; other site 937773000247 H-loop/switch region; other site 937773000248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773000250 putative substrate translocation pore; other site 937773000251 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 937773000252 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 937773000253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000254 putative substrate translocation pore; other site 937773000255 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 937773000256 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 937773000257 putative homodimer interface [polypeptide binding]; other site 937773000258 putative homotetramer interface [polypeptide binding]; other site 937773000259 putative metal binding site [ion binding]; other site 937773000260 putative homodimer-homodimer interface [polypeptide binding]; other site 937773000261 putative allosteric switch controlling residues; other site 937773000262 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 937773000263 active site residue [active] 937773000264 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 937773000265 CPxP motif; other site 937773000266 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 937773000267 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 937773000268 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 937773000269 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 937773000270 active site residue [active] 937773000271 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 937773000272 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 937773000273 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 937773000274 putative active site [active] 937773000275 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 937773000276 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 937773000277 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773000278 active site turn [active] 937773000279 phosphorylation site [posttranslational modification] 937773000280 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 937773000281 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 937773000282 NAD binding site [chemical binding]; other site 937773000283 sugar binding site [chemical binding]; other site 937773000284 divalent metal binding site [ion binding]; other site 937773000285 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773000286 dimer interface [polypeptide binding]; other site 937773000287 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 937773000288 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 937773000289 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 937773000290 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 937773000291 oligomerization interface [polypeptide binding]; other site 937773000292 active site 937773000293 metal binding site [ion binding]; metal-binding site 937773000294 pantoate--beta-alanine ligase; Region: panC; TIGR00018 937773000295 Pantoate-beta-alanine ligase; Region: PanC; cd00560 937773000296 active site 937773000297 ATP-binding site [chemical binding]; other site 937773000298 pantoate-binding site; other site 937773000299 HXXH motif; other site 937773000300 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 937773000301 tetramerization interface [polypeptide binding]; other site 937773000302 active site 937773000303 superantigen-like protein; Reviewed; Region: PRK13036 937773000304 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 937773000305 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 937773000306 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 937773000307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000308 pyruvate phosphate dikinase; Provisional; Region: PRK09279 937773000309 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 937773000310 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 937773000311 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 937773000312 PEP synthetase regulatory protein; Provisional; Region: PRK05339 937773000313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 937773000314 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 937773000315 K+-transporting ATPase, c chain; Region: KdpC; cl00944 937773000316 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 937773000317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773000318 Soluble P-type ATPase [General function prediction only]; Region: COG4087 937773000319 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 937773000320 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 937773000321 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 937773000322 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 937773000323 Ligand Binding Site [chemical binding]; other site 937773000324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773000325 dimer interface [polypeptide binding]; other site 937773000326 phosphorylation site [posttranslational modification] 937773000327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773000328 ATP binding site [chemical binding]; other site 937773000329 Mg2+ binding site [ion binding]; other site 937773000330 G-X-G motif; other site 937773000331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773000332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773000333 active site 937773000334 phosphorylation site [posttranslational modification] 937773000335 intermolecular recognition site; other site 937773000336 dimerization interface [polypeptide binding]; other site 937773000337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773000338 DNA binding site [nucleotide binding] 937773000339 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 937773000340 Na2 binding site [ion binding]; other site 937773000341 putative substrate binding site 1 [chemical binding]; other site 937773000342 Na binding site 1 [ion binding]; other site 937773000343 putative substrate binding site 2 [chemical binding]; other site 937773000344 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 937773000345 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 937773000346 substrate binding pocket [chemical binding]; other site 937773000347 catalytic triad [active] 937773000348 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 937773000349 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 937773000350 dimer interface [polypeptide binding]; other site 937773000351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000352 catalytic residue [active] 937773000353 cystathionine beta-lyase; Provisional; Region: PRK07671 937773000354 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 937773000355 homodimer interface [polypeptide binding]; other site 937773000356 substrate-cofactor binding pocket; other site 937773000357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000358 catalytic residue [active] 937773000359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 937773000360 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 937773000361 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 937773000362 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 937773000363 Surface antigen [General function prediction only]; Region: COG3942 937773000364 CHAP domain; Region: CHAP; pfam05257 937773000365 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 937773000366 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 937773000367 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 937773000368 Protein with unknown function (DUF469); Region: DUF469; cl01237 937773000369 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 937773000370 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 937773000371 Walker A/P-loop; other site 937773000372 ATP binding site [chemical binding]; other site 937773000373 Q-loop/lid; other site 937773000374 ABC transporter signature motif; other site 937773000375 Walker B; other site 937773000376 D-loop; other site 937773000377 H-loop/switch region; other site 937773000378 potential frameshift: common BLAST hit: gi|311070255|ref|YP_003975178.1| antilisterial bacteriocin (subtilosin) production enzyme 937773000379 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 937773000380 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 937773000381 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 937773000382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773000383 FeS/SAM binding site; other site 937773000384 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 937773000385 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 937773000386 putative switch regulator; other site 937773000387 non-specific DNA interactions [nucleotide binding]; other site 937773000388 DNA binding site [nucleotide binding] 937773000389 sequence specific DNA binding site [nucleotide binding]; other site 937773000390 putative cAMP binding site [chemical binding]; other site 937773000391 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 937773000392 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 937773000393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773000394 Walker A/P-loop; other site 937773000395 ATP binding site [chemical binding]; other site 937773000396 Q-loop/lid; other site 937773000397 AAA domain; Region: AAA_21; pfam13304 937773000398 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 937773000399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773000400 Walker A/P-loop; other site 937773000401 ATP binding site [chemical binding]; other site 937773000402 Q-loop/lid; other site 937773000403 ABC transporter signature motif; other site 937773000404 Walker B; other site 937773000405 D-loop; other site 937773000406 H-loop/switch region; other site 937773000407 YibE/F-like protein; Region: YibE_F; cl02259 937773000408 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 937773000409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 937773000410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 937773000411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 937773000412 dimerization interface [polypeptide binding]; other site 937773000413 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 937773000414 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 937773000415 active site 937773000416 dimer interface [polypeptide binding]; other site 937773000417 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 937773000418 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 937773000419 active site 937773000420 FMN binding site [chemical binding]; other site 937773000421 substrate binding site [chemical binding]; other site 937773000422 3Fe-4S cluster binding site [ion binding]; other site 937773000423 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 937773000424 domain interface; other site 937773000425 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 937773000426 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 937773000427 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773000428 active site turn [active] 937773000429 phosphorylation site [posttranslational modification] 937773000430 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 937773000431 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 937773000432 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 937773000433 Ca binding site [ion binding]; other site 937773000434 active site 937773000435 catalytic site [active] 937773000436 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 937773000437 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 937773000438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773000439 DNA-binding site [nucleotide binding]; DNA binding site 937773000440 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 937773000441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773000442 Coenzyme A binding pocket [chemical binding]; other site 937773000443 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 937773000444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773000445 Walker A motif; other site 937773000446 ATP binding site [chemical binding]; other site 937773000447 Walker B motif; other site 937773000448 arginine finger; other site 937773000449 hypothetical protein; Validated; Region: PRK00153 937773000450 recombination protein RecR; Reviewed; Region: recR; PRK00076 937773000451 RecR protein; Region: RecR; pfam02132 937773000452 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 937773000453 putative active site [active] 937773000454 putative metal-binding site [ion binding]; other site 937773000455 tetramer interface [polypeptide binding]; other site 937773000456 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 937773000457 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773000458 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773000459 catalytic residue [active] 937773000460 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 937773000461 thymidylate kinase; Validated; Region: tmk; PRK00698 937773000462 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 937773000463 TMP-binding site; other site 937773000464 ATP-binding site [chemical binding]; other site 937773000465 Protein of unknown function (DUF970); Region: DUF970; pfam06153 937773000466 DNA polymerase III subunit delta'; Validated; Region: PRK08058 937773000467 DNA polymerase III subunit delta'; Validated; Region: PRK08485 937773000468 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 937773000469 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 937773000470 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 937773000471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773000472 S-adenosylmethionine binding site [chemical binding]; other site 937773000473 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 937773000474 GIY-YIG motif/motif A; other site 937773000475 putative active site [active] 937773000476 putative metal binding site [ion binding]; other site 937773000477 Predicted methyltransferases [General function prediction only]; Region: COG0313 937773000478 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 937773000479 putative SAM binding site [chemical binding]; other site 937773000480 putative homodimer interface [polypeptide binding]; other site 937773000481 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 937773000482 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 937773000483 active site 937773000484 HIGH motif; other site 937773000485 KMSKS motif; other site 937773000486 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 937773000487 tRNA binding surface [nucleotide binding]; other site 937773000488 anticodon binding site; other site 937773000489 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 937773000490 dimer interface [polypeptide binding]; other site 937773000491 putative tRNA-binding site [nucleotide binding]; other site 937773000492 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 937773000493 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 937773000494 active site 937773000495 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 937773000496 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 937773000497 putative active site [active] 937773000498 putative metal binding site [ion binding]; other site 937773000499 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 937773000500 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 937773000501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773000502 S-adenosylmethionine binding site [chemical binding]; other site 937773000503 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 937773000504 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 937773000505 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 937773000506 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 937773000507 pur operon repressor; Provisional; Region: PRK09213 937773000508 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 937773000509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773000510 active site 937773000511 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 937773000512 homotrimer interaction site [polypeptide binding]; other site 937773000513 putative active site [active] 937773000514 regulatory protein SpoVG; Reviewed; Region: PRK13259 937773000515 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 937773000516 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 937773000517 Substrate binding site; other site 937773000518 Mg++ binding site; other site 937773000519 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 937773000520 active site 937773000521 substrate binding site [chemical binding]; other site 937773000522 CoA binding site [chemical binding]; other site 937773000523 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 937773000524 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 937773000525 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773000526 active site 937773000527 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 937773000528 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 937773000529 5S rRNA interface [nucleotide binding]; other site 937773000530 CTC domain interface [polypeptide binding]; other site 937773000531 L16 interface [polypeptide binding]; other site 937773000532 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 937773000533 putative active site [active] 937773000534 catalytic residue [active] 937773000535 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 937773000536 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 937773000537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773000538 ATP binding site [chemical binding]; other site 937773000539 putative Mg++ binding site [ion binding]; other site 937773000540 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773000541 nucleotide binding region [chemical binding]; other site 937773000542 ATP-binding site [chemical binding]; other site 937773000543 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 937773000544 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 937773000545 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 937773000546 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 937773000547 putative SAM binding site [chemical binding]; other site 937773000548 putative homodimer interface [polypeptide binding]; other site 937773000549 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 937773000550 homodimer interface [polypeptide binding]; other site 937773000551 metal binding site [ion binding]; metal-binding site 937773000552 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773000553 RNA binding surface [nucleotide binding]; other site 937773000554 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 937773000555 Septum formation initiator; Region: DivIC; pfam04977 937773000556 hypothetical protein; Provisional; Region: PRK08582 937773000557 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 937773000558 RNA binding site [nucleotide binding]; other site 937773000559 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 937773000560 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 937773000561 Ligand Binding Site [chemical binding]; other site 937773000562 TilS substrate C-terminal domain; Region: TilS_C; smart00977 937773000563 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773000564 active site 937773000565 FtsH Extracellular; Region: FtsH_ext; pfam06480 937773000566 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 937773000567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773000568 Walker A motif; other site 937773000569 ATP binding site [chemical binding]; other site 937773000570 Walker B motif; other site 937773000571 arginine finger; other site 937773000572 Peptidase family M41; Region: Peptidase_M41; pfam01434 937773000573 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 937773000574 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 937773000575 dimerization interface [polypeptide binding]; other site 937773000576 domain crossover interface; other site 937773000577 redox-dependent activation switch; other site 937773000578 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 937773000579 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 937773000580 dimer interface [polypeptide binding]; other site 937773000581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000582 catalytic residue [active] 937773000583 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 937773000584 dihydropteroate synthase; Region: DHPS; TIGR01496 937773000585 substrate binding pocket [chemical binding]; other site 937773000586 dimer interface [polypeptide binding]; other site 937773000587 inhibitor binding site; inhibition site 937773000588 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 937773000589 homooctamer interface [polypeptide binding]; other site 937773000590 active site 937773000591 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 937773000592 catalytic center binding site [active] 937773000593 ATP binding site [chemical binding]; other site 937773000594 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 937773000595 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 937773000596 FMN binding site [chemical binding]; other site 937773000597 active site 937773000598 catalytic residues [active] 937773000599 substrate binding site [chemical binding]; other site 937773000600 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 937773000601 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 937773000602 dimer interface [polypeptide binding]; other site 937773000603 putative anticodon binding site; other site 937773000604 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 937773000605 motif 1; other site 937773000606 active site 937773000607 motif 2; other site 937773000608 motif 3; other site 937773000609 Predicted membrane protein [Function unknown]; Region: COG1289 937773000610 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 937773000611 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 937773000612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773000613 DNA-binding site [nucleotide binding]; DNA binding site 937773000614 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773000615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000616 homodimer interface [polypeptide binding]; other site 937773000617 catalytic residue [active] 937773000618 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 937773000619 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 937773000620 active site 937773000621 multimer interface [polypeptide binding]; other site 937773000622 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 937773000623 predicted active site [active] 937773000624 catalytic triad [active] 937773000625 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 937773000626 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 937773000627 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 937773000628 Nucleoside recognition; Region: Gate; pfam07670 937773000629 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 937773000630 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 937773000631 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 937773000632 UvrB/uvrC motif; Region: UVR; pfam02151 937773000633 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 937773000634 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 937773000635 ADP binding site [chemical binding]; other site 937773000636 phosphagen binding site; other site 937773000637 substrate specificity loop; other site 937773000638 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 937773000639 Clp amino terminal domain; Region: Clp_N; pfam02861 937773000640 Clp amino terminal domain; Region: Clp_N; pfam02861 937773000641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773000642 Walker A motif; other site 937773000643 ATP binding site [chemical binding]; other site 937773000644 Walker B motif; other site 937773000645 arginine finger; other site 937773000646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773000647 Walker A motif; other site 937773000648 ATP binding site [chemical binding]; other site 937773000649 Walker B motif; other site 937773000650 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 937773000651 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 937773000652 YcaO-like family; Region: YcaO; pfam02624 937773000653 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 937773000654 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 937773000655 putative FMN binding site [chemical binding]; other site 937773000656 NADPH bind site [chemical binding]; other site 937773000657 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 937773000658 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 937773000659 Walker A/P-loop; other site 937773000660 ATP binding site [chemical binding]; other site 937773000661 Q-loop/lid; other site 937773000662 ABC transporter signature motif; other site 937773000663 Walker B; other site 937773000664 D-loop; other site 937773000665 H-loop/switch region; other site 937773000666 DNA repair protein RadA; Provisional; Region: PRK11823 937773000667 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 937773000668 Walker A motif/ATP binding site; other site 937773000669 ATP binding site [chemical binding]; other site 937773000670 Walker B motif; other site 937773000671 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 937773000672 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 937773000673 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 937773000674 putative active site [active] 937773000675 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 937773000676 substrate binding site; other site 937773000677 dimer interface; other site 937773000678 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 937773000679 homotrimer interaction site [polypeptide binding]; other site 937773000680 zinc binding site [ion binding]; other site 937773000681 CDP-binding sites; other site 937773000682 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 937773000683 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 937773000684 active site 937773000685 HIGH motif; other site 937773000686 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 937773000687 active site 937773000688 KMSKS motif; other site 937773000689 serine O-acetyltransferase; Region: cysE; TIGR01172 937773000690 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 937773000691 trimer interface [polypeptide binding]; other site 937773000692 active site 937773000693 substrate binding site [chemical binding]; other site 937773000694 CoA binding site [chemical binding]; other site 937773000695 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 937773000696 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 937773000697 active site 937773000698 HIGH motif; other site 937773000699 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 937773000700 KMSKS motif; other site 937773000701 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 937773000702 tRNA binding surface [nucleotide binding]; other site 937773000703 anticodon binding site; other site 937773000704 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 937773000705 dimerization interface [polypeptide binding]; other site 937773000706 active site 937773000707 metal binding site [ion binding]; metal-binding site 937773000708 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 937773000709 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 937773000710 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 937773000711 YacP-like NYN domain; Region: NYN_YacP; cl01491 937773000712 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 937773000713 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 937773000714 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 937773000715 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 937773000716 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 937773000717 putative homodimer interface [polypeptide binding]; other site 937773000718 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 937773000719 heterodimer interface [polypeptide binding]; other site 937773000720 homodimer interface [polypeptide binding]; other site 937773000721 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 937773000722 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 937773000723 23S rRNA interface [nucleotide binding]; other site 937773000724 L7/L12 interface [polypeptide binding]; other site 937773000725 putative thiostrepton binding site; other site 937773000726 L25 interface [polypeptide binding]; other site 937773000727 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 937773000728 mRNA/rRNA interface [nucleotide binding]; other site 937773000729 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 937773000730 23S rRNA interface [nucleotide binding]; other site 937773000731 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 937773000732 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 937773000733 peripheral dimer interface [polypeptide binding]; other site 937773000734 core dimer interface [polypeptide binding]; other site 937773000735 L10 interface [polypeptide binding]; other site 937773000736 L11 interface [polypeptide binding]; other site 937773000737 putative EF-Tu interaction site [polypeptide binding]; other site 937773000738 putative EF-G interaction site [polypeptide binding]; other site 937773000739 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 937773000740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773000741 S-adenosylmethionine binding site [chemical binding]; other site 937773000742 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 937773000743 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 937773000744 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 937773000745 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 937773000746 RPB12 interaction site [polypeptide binding]; other site 937773000747 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 937773000748 RPB10 interaction site [polypeptide binding]; other site 937773000749 RPB1 interaction site [polypeptide binding]; other site 937773000750 RPB11 interaction site [polypeptide binding]; other site 937773000751 RPB3 interaction site [polypeptide binding]; other site 937773000752 RPB12 interaction site [polypeptide binding]; other site 937773000753 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 937773000754 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 937773000755 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 937773000756 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 937773000757 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 937773000758 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 937773000759 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 937773000760 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 937773000761 G-loop; other site 937773000762 DNA binding site [nucleotide binding] 937773000763 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 937773000764 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 937773000765 S17 interaction site [polypeptide binding]; other site 937773000766 S8 interaction site; other site 937773000767 16S rRNA interaction site [nucleotide binding]; other site 937773000768 streptomycin interaction site [chemical binding]; other site 937773000769 23S rRNA interaction site [nucleotide binding]; other site 937773000770 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 937773000771 30S ribosomal protein S7; Validated; Region: PRK05302 937773000772 elongation factor G; Reviewed; Region: PRK00007 937773000773 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 937773000774 G1 box; other site 937773000775 putative GEF interaction site [polypeptide binding]; other site 937773000776 GTP/Mg2+ binding site [chemical binding]; other site 937773000777 Switch I region; other site 937773000778 G2 box; other site 937773000779 G3 box; other site 937773000780 Switch II region; other site 937773000781 G4 box; other site 937773000782 G5 box; other site 937773000783 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 937773000784 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 937773000785 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 937773000786 elongation factor Tu; Reviewed; Region: PRK00049 937773000787 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 937773000788 G1 box; other site 937773000789 GEF interaction site [polypeptide binding]; other site 937773000790 GTP/Mg2+ binding site [chemical binding]; other site 937773000791 Switch I region; other site 937773000792 G2 box; other site 937773000793 G3 box; other site 937773000794 Switch II region; other site 937773000795 G4 box; other site 937773000796 G5 box; other site 937773000797 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 937773000798 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 937773000799 Antibiotic Binding Site [chemical binding]; other site 937773000800 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 937773000801 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 937773000802 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 937773000803 metal binding site [ion binding]; metal-binding site 937773000804 dimer interface [polypeptide binding]; other site 937773000805 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 937773000806 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 937773000807 substrate-cofactor binding pocket; other site 937773000808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773000809 catalytic residue [active] 937773000810 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 937773000811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773000812 NAD(P) binding site [chemical binding]; other site 937773000813 active site 937773000814 Transposase IS200 like; Region: Y1_Tnp; cl00848 937773000815 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 937773000816 potential frameshift: common BLAST hit: gi|289550013|ref|YP_003470917.1| ABC transporter (ATP-binding protein) 937773000817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773000818 Walker A/P-loop; other site 937773000819 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 937773000820 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773000821 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 937773000822 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 937773000823 homodimer interface [polypeptide binding]; other site 937773000824 substrate-cofactor binding pocket; other site 937773000825 catalytic residue [active] 937773000826 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 937773000827 putative catalytic site [active] 937773000828 metal binding site A [ion binding]; metal-binding site 937773000829 phosphate binding site [ion binding]; other site 937773000830 metal binding site C [ion binding]; metal-binding site 937773000831 metal binding site B [ion binding]; metal-binding site 937773000832 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 937773000833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773000834 motif II; other site 937773000835 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 937773000836 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 937773000837 Substrate-binding site [chemical binding]; other site 937773000838 Substrate specificity [chemical binding]; other site 937773000839 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 937773000840 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 937773000841 Substrate-binding site [chemical binding]; other site 937773000842 Substrate specificity [chemical binding]; other site 937773000843 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 937773000844 nucleoside/Zn binding site; other site 937773000845 dimer interface [polypeptide binding]; other site 937773000846 catalytic motif [active] 937773000847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773000848 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 937773000849 active site 937773000850 motif I; other site 937773000851 motif II; other site 937773000852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773000853 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 937773000854 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 937773000855 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 937773000856 Walker A/P-loop; other site 937773000857 ATP binding site [chemical binding]; other site 937773000858 Q-loop/lid; other site 937773000859 ABC transporter signature motif; other site 937773000860 Walker B; other site 937773000861 D-loop; other site 937773000862 H-loop/switch region; other site 937773000863 putative GTP cyclohydrolase; Provisional; Region: PRK13674 937773000864 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 937773000865 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 937773000866 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 937773000867 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 937773000868 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 937773000869 putative active site [active] 937773000870 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 937773000871 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 937773000872 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773000873 active site turn [active] 937773000874 phosphorylation site [posttranslational modification] 937773000875 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 937773000876 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 937773000877 putative active site cavity [active] 937773000878 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 937773000879 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 937773000880 active site 937773000881 trimer interface [polypeptide binding]; other site 937773000882 allosteric site; other site 937773000883 active site lid [active] 937773000884 hexamer (dimer of trimers) interface [polypeptide binding]; other site 937773000885 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 937773000886 active site 937773000887 dimer interface [polypeptide binding]; other site 937773000888 magnesium binding site [ion binding]; other site 937773000889 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 937773000890 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 937773000891 tetramer interface [polypeptide binding]; other site 937773000892 active site 937773000893 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 937773000894 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 937773000895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000896 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773000897 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 937773000898 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 937773000899 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 937773000900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000901 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 937773000902 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773000903 Adhesion protein FadA; Region: FadA; pfam09403 937773000904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773000905 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 937773000906 catalytic core [active] 937773000907 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 937773000908 acyl-CoA synthetase; Validated; Region: PRK07638 937773000909 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 937773000910 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 937773000911 acyl-activating enzyme (AAE) consensus motif; other site 937773000912 AMP binding site [chemical binding]; other site 937773000913 active site 937773000914 acyl-activating enzyme (AAE) consensus motif; other site 937773000915 CoA binding site [chemical binding]; other site 937773000916 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 937773000917 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 937773000918 dimer interface [polypeptide binding]; other site 937773000919 active site 937773000920 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 937773000921 dimer interface [polypeptide binding]; other site 937773000922 substrate binding site [chemical binding]; other site 937773000923 ATP binding site [chemical binding]; other site 937773000924 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 937773000925 ligand binding site [chemical binding]; other site 937773000926 active site 937773000927 UGI interface [polypeptide binding]; other site 937773000928 catalytic site [active] 937773000929 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 937773000930 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 937773000931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773000932 FeS/SAM binding site; other site 937773000933 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 937773000934 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 937773000935 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 937773000936 dimer interface [polypeptide binding]; other site 937773000937 N-terminal domain interface [polypeptide binding]; other site 937773000938 substrate binding pocket (H-site) [chemical binding]; other site 937773000939 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 937773000940 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 937773000941 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 937773000942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 937773000943 Predicted membrane protein [Function unknown]; Region: COG2311 937773000944 Protein of unknown function (DUF418); Region: DUF418; cl12135 937773000945 Protein of unknown function (DUF418); Region: DUF418; pfam04235 937773000946 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 937773000947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 937773000948 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 937773000949 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 937773000950 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 937773000951 HlyD family secretion protein; Region: HlyD_3; pfam13437 937773000952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000953 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 937773000954 putative substrate translocation pore; other site 937773000955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773000956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 937773000957 dimerization interface [polypeptide binding]; other site 937773000958 putative DNA binding site [nucleotide binding]; other site 937773000959 putative Zn2+ binding site [ion binding]; other site 937773000960 arsenical pump membrane protein; Provisional; Region: PRK15445 937773000961 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 937773000962 transmembrane helices; other site 937773000963 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 937773000964 Low molecular weight phosphatase family; Region: LMWPc; cd00115 937773000965 active site 937773000966 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 937773000967 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 937773000968 putative heme peroxidase; Provisional; Region: PRK12276 937773000969 PemK-like protein; Region: PemK; pfam02452 937773000970 Uncharacterized conserved protein [Function unknown]; Region: COG2966 937773000971 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 937773000972 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 937773000973 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 937773000974 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 937773000975 transmembrane helices; other site 937773000976 Predicted transcriptional regulators [Transcription]; Region: COG1695 937773000977 Transcriptional regulator PadR-like family; Region: PadR; cl17335 937773000978 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 937773000979 cleavage site 937773000980 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 937773000981 active site 937773000982 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000983 active site 937773000984 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 937773000985 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 937773000986 active site 937773000987 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000988 active site 937773000989 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 937773000990 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 937773000991 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773000992 active site 937773000993 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 937773000994 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 937773000995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 937773000996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773000997 Coenzyme A binding pocket [chemical binding]; other site 937773000998 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 937773000999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 937773001000 Zn2+ binding site [ion binding]; other site 937773001001 Mg2+ binding site [ion binding]; other site 937773001002 YwhD family; Region: YwhD; pfam08741 937773001003 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 937773001004 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 937773001005 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 937773001006 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 937773001007 active site 937773001008 HIGH motif; other site 937773001009 KMSK motif region; other site 937773001010 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 937773001011 tRNA binding surface [nucleotide binding]; other site 937773001012 anticodon binding site; other site 937773001013 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 937773001014 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 937773001015 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 937773001016 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 937773001017 putative binding site residues; other site 937773001018 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 937773001019 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001020 ABC-ATPase subunit interface; other site 937773001021 dimer interface [polypeptide binding]; other site 937773001022 putative PBP binding regions; other site 937773001023 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 937773001024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773001025 motif II; other site 937773001026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 937773001027 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 937773001028 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 937773001029 Protein of unknown function, DUF606; Region: DUF606; pfam04657 937773001030 Protein of unknown function, DUF606; Region: DUF606; pfam04657 937773001031 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 937773001032 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 937773001033 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 937773001034 active site 937773001035 DNA binding site [nucleotide binding] 937773001036 Int/Topo IB signature motif; other site 937773001037 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 937773001038 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 937773001039 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 937773001040 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 937773001041 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 937773001042 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 937773001043 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 937773001044 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 937773001045 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 937773001046 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 937773001047 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 937773001048 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 937773001049 intersubunit interface [polypeptide binding]; other site 937773001050 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 937773001051 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001052 ABC-ATPase subunit interface; other site 937773001053 dimer interface [polypeptide binding]; other site 937773001054 putative PBP binding regions; other site 937773001055 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 937773001056 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 937773001057 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 937773001058 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 937773001059 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 937773001060 FeoA domain; Region: FeoA; pfam04023 937773001061 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 937773001062 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001063 ABC-ATPase subunit interface; other site 937773001064 dimer interface [polypeptide binding]; other site 937773001065 putative PBP binding regions; other site 937773001066 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 937773001067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001068 ABC-ATPase subunit interface; other site 937773001069 dimer interface [polypeptide binding]; other site 937773001070 putative PBP binding regions; other site 937773001071 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 937773001072 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 937773001073 siderophore binding site; other site 937773001074 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 937773001075 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 937773001076 dimer interface [polypeptide binding]; other site 937773001077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773001078 catalytic residue [active] 937773001079 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 937773001080 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 937773001081 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773001082 IucA / IucC family; Region: IucA_IucC; pfam04183 937773001083 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773001084 drug efflux system protein MdtG; Provisional; Region: PRK09874 937773001085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001086 putative substrate translocation pore; other site 937773001087 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773001088 IucA / IucC family; Region: IucA_IucC; pfam04183 937773001089 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773001090 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773001091 IucA / IucC family; Region: IucA_IucC; pfam04183 937773001092 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773001093 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 937773001094 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 937773001095 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 937773001096 dimer interface [polypeptide binding]; other site 937773001097 active site 937773001098 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773001099 catalytic residues [active] 937773001100 substrate binding site [chemical binding]; other site 937773001101 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 937773001102 ParB-like nuclease domain; Region: ParBc; pfam02195 937773001103 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 937773001104 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 937773001105 putative trimer interface [polypeptide binding]; other site 937773001106 putative CoA binding site [chemical binding]; other site 937773001107 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 937773001108 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 937773001109 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 937773001110 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 937773001111 Walker A/P-loop; other site 937773001112 ATP binding site [chemical binding]; other site 937773001113 Q-loop/lid; other site 937773001114 ABC transporter signature motif; other site 937773001115 Walker B; other site 937773001116 D-loop; other site 937773001117 H-loop/switch region; other site 937773001118 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 937773001119 ABC-2 type transporter; Region: ABC2_membrane; cl17235 937773001120 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 937773001121 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 937773001122 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 937773001123 active site 937773001124 nucleotide binding site [chemical binding]; other site 937773001125 HIGH motif; other site 937773001126 KMSKS motif; other site 937773001127 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773001128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001129 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 937773001130 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 937773001131 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 937773001132 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 937773001133 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 937773001134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773001135 Walker A/P-loop; other site 937773001136 ATP binding site [chemical binding]; other site 937773001137 Q-loop/lid; other site 937773001138 ABC transporter signature motif; other site 937773001139 Walker B; other site 937773001140 D-loop; other site 937773001141 H-loop/switch region; other site 937773001142 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 937773001143 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 937773001144 G1 box; other site 937773001145 GTP/Mg2+ binding site [chemical binding]; other site 937773001146 Switch I region; other site 937773001147 G2 box; other site 937773001148 G3 box; other site 937773001149 Switch II region; other site 937773001150 G4 box; other site 937773001151 G5 box; other site 937773001152 Nucleoside recognition; Region: Gate; pfam07670 937773001153 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 937773001154 Nucleoside recognition; Region: Gate; pfam07670 937773001155 FeoA domain; Region: FeoA; pfam04023 937773001156 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 937773001157 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 937773001158 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 937773001159 Uncharacterized conserved protein [Function unknown]; Region: COG1284 937773001160 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 937773001161 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 937773001162 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 937773001163 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 937773001164 Walker A/P-loop; other site 937773001165 ATP binding site [chemical binding]; other site 937773001166 Q-loop/lid; other site 937773001167 ABC transporter signature motif; other site 937773001168 Walker B; other site 937773001169 D-loop; other site 937773001170 H-loop/switch region; other site 937773001171 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 937773001172 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001173 ABC-ATPase subunit interface; other site 937773001174 dimer interface [polypeptide binding]; other site 937773001175 putative PBP binding regions; other site 937773001176 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 937773001177 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773001178 ABC-ATPase subunit interface; other site 937773001179 dimer interface [polypeptide binding]; other site 937773001180 putative PBP binding regions; other site 937773001181 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 937773001182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001183 putative substrate translocation pore; other site 937773001184 Uncharacterized membrane protein [Function unknown]; Region: COG3949 937773001185 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 937773001186 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 937773001187 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 937773001188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773001189 Coenzyme A binding pocket [chemical binding]; other site 937773001190 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 937773001191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001192 NAD(P) binding site [chemical binding]; other site 937773001193 active site 937773001194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773001195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773001196 active site 937773001197 phosphorylation site [posttranslational modification] 937773001198 intermolecular recognition site; other site 937773001199 dimerization interface [polypeptide binding]; other site 937773001200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773001201 DNA binding site [nucleotide binding] 937773001202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 937773001203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773001204 ATP binding site [chemical binding]; other site 937773001205 Mg2+ binding site [ion binding]; other site 937773001206 G-X-G motif; other site 937773001207 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 937773001208 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 937773001209 Walker A/P-loop; other site 937773001210 ATP binding site [chemical binding]; other site 937773001211 Q-loop/lid; other site 937773001212 ABC transporter signature motif; other site 937773001213 Walker B; other site 937773001214 D-loop; other site 937773001215 H-loop/switch region; other site 937773001216 FtsX-like permease family; Region: FtsX; pfam02687 937773001217 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 937773001218 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 937773001219 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 937773001220 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 937773001221 Surface antigen [General function prediction only]; Region: COG3942 937773001222 CHAP domain; Region: CHAP; pfam05257 937773001223 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 937773001224 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 937773001225 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 937773001226 thiamine phosphate binding site [chemical binding]; other site 937773001227 active site 937773001228 pyrophosphate binding site [ion binding]; other site 937773001229 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 937773001230 thiS-thiF/thiG interaction site; other site 937773001231 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 937773001232 ThiS interaction site; other site 937773001233 putative active site [active] 937773001234 tetramer interface [polypeptide binding]; other site 937773001235 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 937773001236 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 937773001237 ATP binding site [chemical binding]; other site 937773001238 substrate interface [chemical binding]; other site 937773001239 hypothetical protein; Provisional; Region: PRK12378 937773001240 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 937773001241 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 937773001242 Transcriptional regulator [Transcription]; Region: LysR; COG0583 937773001243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 937773001244 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 937773001245 dimerization interface [polypeptide binding]; other site 937773001246 sugar efflux transporter; Region: 2A0120; TIGR00899 937773001247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001248 putative substrate translocation pore; other site 937773001249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 937773001250 NADH dehydrogenase; Region: NADHdh; cl00469 937773001251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 937773001252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773001253 Coenzyme A binding pocket [chemical binding]; other site 937773001254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 937773001255 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 937773001256 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 937773001257 hypothetical protein; Validated; Region: PRK00124 937773001258 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 937773001259 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 937773001260 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 937773001261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773001262 Walker A/P-loop; other site 937773001263 ATP binding site [chemical binding]; other site 937773001264 Q-loop/lid; other site 937773001265 ABC transporter signature motif; other site 937773001266 Walker B; other site 937773001267 D-loop; other site 937773001268 H-loop/switch region; other site 937773001269 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 937773001270 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 937773001271 Walker A/P-loop; other site 937773001272 ATP binding site [chemical binding]; other site 937773001273 Q-loop/lid; other site 937773001274 ABC transporter signature motif; other site 937773001275 Walker B; other site 937773001276 D-loop; other site 937773001277 H-loop/switch region; other site 937773001278 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773001279 MarR family; Region: MarR; pfam01047 937773001280 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 937773001281 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 937773001282 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 937773001283 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 937773001284 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 937773001285 active site 937773001286 catalytic tetrad [active] 937773001287 potential frameshift: common BLAST hit: gi|29377686|ref|NP_816840.1| abortive phage resistance protein 937773001288 AAA domain; Region: AAA_21; pfam13304 937773001289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773001290 Walker A/P-loop; other site 937773001291 ATP binding site [chemical binding]; other site 937773001292 AAA domain; Region: AAA_21; pfam13304 937773001293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773001294 ABC transporter signature motif; other site 937773001295 Walker B; other site 937773001296 D-loop; other site 937773001297 H-loop/switch region; other site 937773001298 malate dehydrogenase; Reviewed; Region: PRK06223 937773001299 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 937773001300 NAD(P) binding site [chemical binding]; other site 937773001301 dimer interface [polypeptide binding]; other site 937773001302 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773001303 substrate binding site [chemical binding]; other site 937773001304 CAAX protease self-immunity; Region: Abi; pfam02517 937773001305 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 937773001306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773001307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001308 putative substrate translocation pore; other site 937773001309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 937773001310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 937773001311 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 937773001312 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 937773001313 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 937773001314 putative deacylase active site [active] 937773001315 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 937773001316 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 937773001317 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 937773001318 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 937773001319 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 937773001320 putative substrate binding site [chemical binding]; other site 937773001321 putative ATP binding site [chemical binding]; other site 937773001322 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 937773001323 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773001324 active site 937773001325 phosphorylation site [posttranslational modification] 937773001326 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 937773001327 active site 937773001328 P-loop; other site 937773001329 phosphorylation site [posttranslational modification] 937773001330 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 937773001331 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 937773001332 Domain of unknown function DUF21; Region: DUF21; pfam01595 937773001333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 937773001334 Transporter associated domain; Region: CorC_HlyC; smart01091 937773001335 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 937773001336 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 937773001337 Ligand binding site; other site 937773001338 Putative Catalytic site; other site 937773001339 DXD motif; other site 937773001340 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 937773001341 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 937773001342 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773001343 FeS/SAM binding site; other site 937773001344 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 937773001345 active site 937773001346 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 937773001347 Ligand Binding Site [chemical binding]; other site 937773001348 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 937773001349 Glutamine amidotransferase class-I; Region: GATase; pfam00117 937773001350 glutamine binding [chemical binding]; other site 937773001351 catalytic triad [active] 937773001352 aminodeoxychorismate synthase; Provisional; Region: PRK07508 937773001353 chorismate binding enzyme; Region: Chorismate_bind; cl10555 937773001354 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 937773001355 substrate-cofactor binding pocket; other site 937773001356 Aminotransferase class IV; Region: Aminotran_4; pfam01063 937773001357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773001358 catalytic residue [active] 937773001359 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 937773001360 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 937773001361 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 937773001362 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 937773001363 Sulfatase; Region: Sulfatase; pfam00884 937773001364 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 937773001365 active site 937773001366 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 937773001367 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 937773001368 putative active site [active] 937773001369 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 937773001370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773001371 Walker A/P-loop; other site 937773001372 ATP binding site [chemical binding]; other site 937773001373 Q-loop/lid; other site 937773001374 ABC transporter signature motif; other site 937773001375 Walker B; other site 937773001376 D-loop; other site 937773001377 H-loop/switch region; other site 937773001378 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 937773001379 ZIP Zinc transporter; Region: Zip; pfam02535 937773001380 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 937773001381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773001382 Walker A/P-loop; other site 937773001383 ATP binding site [chemical binding]; other site 937773001384 Q-loop/lid; other site 937773001385 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773001386 ABC transporter signature motif; other site 937773001387 Walker B; other site 937773001388 D-loop; other site 937773001389 ABC transporter; Region: ABC_tran_2; pfam12848 937773001390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773001391 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 937773001392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773001393 ATP binding site [chemical binding]; other site 937773001394 putative Mg++ binding site [ion binding]; other site 937773001395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773001396 nucleotide binding region [chemical binding]; other site 937773001397 ATP-binding site [chemical binding]; other site 937773001398 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 937773001399 HRDC domain; Region: HRDC; pfam00570 937773001400 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 937773001401 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 937773001402 Walker A/P-loop; other site 937773001403 ATP binding site [chemical binding]; other site 937773001404 Q-loop/lid; other site 937773001405 ABC transporter signature motif; other site 937773001406 Walker B; other site 937773001407 D-loop; other site 937773001408 H-loop/switch region; other site 937773001409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773001410 dimer interface [polypeptide binding]; other site 937773001411 conserved gate region; other site 937773001412 ABC-ATPase subunit interface; other site 937773001413 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 937773001414 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 937773001415 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 937773001416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773001417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773001418 homodimer interface [polypeptide binding]; other site 937773001419 catalytic residue [active] 937773001420 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 937773001421 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 937773001422 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 937773001423 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 937773001424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001425 putative substrate translocation pore; other site 937773001426 POT family; Region: PTR2; cl17359 937773001427 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 937773001428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773001429 putative substrate translocation pore; other site 937773001430 POT family; Region: PTR2; cl17359 937773001431 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773001432 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 937773001433 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 937773001434 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 937773001435 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 937773001436 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 937773001437 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 937773001438 Class I ribonucleotide reductase; Region: RNR_I; cd01679 937773001439 active site 937773001440 dimer interface [polypeptide binding]; other site 937773001441 catalytic residues [active] 937773001442 effector binding site; other site 937773001443 R2 peptide binding site; other site 937773001444 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 937773001445 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 937773001446 dimer interface [polypeptide binding]; other site 937773001447 putative radical transfer pathway; other site 937773001448 diiron center [ion binding]; other site 937773001449 tyrosyl radical; other site 937773001450 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 937773001451 CHY zinc finger; Region: zf-CHY; pfam05495 937773001452 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 937773001453 FAD binding domain; Region: FAD_binding_4; pfam01565 937773001454 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 937773001455 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 937773001456 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 937773001457 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 937773001458 peptidase T; Region: peptidase-T; TIGR01882 937773001459 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 937773001460 metal binding site [ion binding]; metal-binding site 937773001461 dimer interface [polypeptide binding]; other site 937773001462 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 937773001463 Uncharacterized conserved protein [Function unknown]; Region: COG2966 937773001464 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 937773001465 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 937773001466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 937773001467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 937773001468 metal binding site [ion binding]; metal-binding site 937773001469 active site 937773001470 I-site; other site 937773001471 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 937773001472 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 937773001473 Mg++ binding site [ion binding]; other site 937773001474 putative catalytic motif [active] 937773001475 substrate binding site [chemical binding]; other site 937773001476 Uncharacterized conserved protein [Function unknown]; Region: COG1739 937773001477 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 937773001478 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 937773001479 EDD domain protein, DegV family; Region: DegV; TIGR00762 937773001480 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 937773001481 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 937773001482 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773001483 ATP binding site [chemical binding]; other site 937773001484 putative Mg++ binding site [ion binding]; other site 937773001485 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773001486 nucleotide binding region [chemical binding]; other site 937773001487 ATP-binding site [chemical binding]; other site 937773001488 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 937773001489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773001490 active site 937773001491 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 937773001492 30S subunit binding site; other site 937773001493 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 937773001494 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 937773001495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773001496 nucleotide binding region [chemical binding]; other site 937773001497 ATP-binding site [chemical binding]; other site 937773001498 SEC-C motif; Region: SEC-C; pfam02810 937773001499 peptide chain release factor 2; Provisional; Region: PRK06746 937773001500 This domain is found in peptide chain release factors; Region: PCRF; smart00937 937773001501 RF-1 domain; Region: RF-1; pfam00472 937773001502 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 937773001503 Zn2+ binding site [ion binding]; other site 937773001504 Mg2+ binding site [ion binding]; other site 937773001505 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 937773001506 excinuclease ABC subunit B; Provisional; Region: PRK05298 937773001507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773001508 ATP binding site [chemical binding]; other site 937773001509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773001510 nucleotide binding region [chemical binding]; other site 937773001511 ATP-binding site [chemical binding]; other site 937773001512 Ultra-violet resistance protein B; Region: UvrB; pfam12344 937773001513 UvrB/uvrC motif; Region: UVR; pfam02151 937773001514 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 937773001515 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 937773001516 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 937773001517 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 937773001518 HPr kinase/phosphorylase; Provisional; Region: PRK05428 937773001519 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 937773001520 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 937773001521 Hpr binding site; other site 937773001522 active site 937773001523 homohexamer subunit interaction site [polypeptide binding]; other site 937773001524 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 937773001525 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 937773001526 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 937773001527 trimer interface [polypeptide binding]; other site 937773001528 active site 937773001529 substrate binding site [chemical binding]; other site 937773001530 CoA binding site [chemical binding]; other site 937773001531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773001532 binding surface 937773001533 TPR motif; other site 937773001534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 937773001535 TPR motif; other site 937773001536 binding surface 937773001537 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 937773001538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 937773001539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773001540 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 937773001541 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 937773001542 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 937773001543 phosphate binding site [ion binding]; other site 937773001544 putative substrate binding pocket [chemical binding]; other site 937773001545 dimer interface [polypeptide binding]; other site 937773001546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 937773001547 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 937773001548 Clp protease; Region: CLP_protease; pfam00574 937773001549 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 937773001550 oligomer interface [polypeptide binding]; other site 937773001551 active site residues [active] 937773001552 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 937773001553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773001554 Coenzyme A binding pocket [chemical binding]; other site 937773001555 potential frameshift: common BLAST hit: gi|289551369|ref|YP_003472273.1| cell division inhibitor 937773001556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773001558 NAD(P) binding site [chemical binding]; other site 937773001559 active site 937773001560 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 937773001561 Predicted transcriptional regulator [Transcription]; Region: COG3388 937773001562 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 937773001563 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 937773001564 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 937773001565 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 937773001566 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 937773001567 Phosphoglycerate kinase; Region: PGK; pfam00162 937773001568 substrate binding site [chemical binding]; other site 937773001569 hinge regions; other site 937773001570 ADP binding site [chemical binding]; other site 937773001571 catalytic site [active] 937773001572 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 937773001573 triosephosphate isomerase; Provisional; Region: PRK14565 937773001574 substrate binding site [chemical binding]; other site 937773001575 dimer interface [polypeptide binding]; other site 937773001576 catalytic triad [active] 937773001577 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 937773001578 phosphoglyceromutase; Provisional; Region: PRK05434 937773001579 enolase; Provisional; Region: eno; PRK00077 937773001580 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 937773001581 dimer interface [polypeptide binding]; other site 937773001582 metal binding site [ion binding]; metal-binding site 937773001583 substrate binding pocket [chemical binding]; other site 937773001584 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 937773001585 Esterase/lipase [General function prediction only]; Region: COG1647 937773001586 ribonuclease R; Region: RNase_R; TIGR02063 937773001587 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 937773001588 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 937773001589 RNB domain; Region: RNB; pfam00773 937773001590 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 937773001591 RNA binding site [nucleotide binding]; other site 937773001592 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 937773001593 SmpB-tmRNA interface; other site 937773001594 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 937773001595 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 937773001596 Int/Topo IB signature motif; other site 937773001597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773001598 non-specific DNA binding site [nucleotide binding]; other site 937773001599 salt bridge; other site 937773001600 sequence-specific DNA binding site [nucleotide binding]; other site 937773001601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773001602 salt bridge; other site 937773001603 non-specific DNA binding site [nucleotide binding]; other site 937773001604 sequence-specific DNA binding site [nucleotide binding]; other site 937773001605 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 937773001606 Uncharacterized conserved protein [Function unknown]; Region: COG4983 937773001607 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 937773001608 nucleotide binding site [chemical binding]; other site 937773001609 D5 N terminal like; Region: D5_N; smart00885 937773001610 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 937773001611 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 937773001612 Phage-related protein [Function unknown]; Region: COG4695; cl01923 937773001613 Phage portal protein; Region: Phage_portal; pfam04860 937773001614 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 937773001615 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 937773001616 Phage capsid family; Region: Phage_capsid; pfam05065 937773001617 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 937773001618 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 937773001619 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 937773001620 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 937773001621 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 937773001622 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 937773001623 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 937773001624 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773001625 active site 937773001626 metal binding site [ion binding]; metal-binding site 937773001627 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 937773001628 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 937773001629 Beta-lactamase; Region: Beta-lactamase; pfam00144 937773001630 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 937773001631 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 937773001632 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 937773001633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773001634 Coenzyme A binding pocket [chemical binding]; other site 937773001635 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 937773001636 D-lactate dehydrogenase; Validated; Region: PRK08605 937773001637 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 937773001638 homodimer interface [polypeptide binding]; other site 937773001639 ligand binding site [chemical binding]; other site 937773001640 NAD binding site [chemical binding]; other site 937773001641 catalytic site [active] 937773001642 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 937773001643 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 937773001644 active site 937773001645 catalytic residue [active] 937773001646 dimer interface [polypeptide binding]; other site 937773001647 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 937773001648 putative FMN binding site [chemical binding]; other site 937773001649 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773001650 catalytic residues [active] 937773001651 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 937773001652 ArsC family; Region: ArsC; pfam03960 937773001653 putative ArsC-like catalytic residues; other site 937773001654 putative TRX-like catalytic residues [active] 937773001655 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 937773001656 lipoyl attachment site [posttranslational modification]; other site 937773001657 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 937773001658 putative active site [active] 937773001659 putative metal binding site [ion binding]; other site 937773001660 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773001661 catalytic residues [active] 937773001662 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 937773001663 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 937773001664 Walker A/P-loop; other site 937773001665 ATP binding site [chemical binding]; other site 937773001666 Q-loop/lid; other site 937773001667 ABC transporter signature motif; other site 937773001668 Walker B; other site 937773001669 D-loop; other site 937773001670 H-loop/switch region; other site 937773001671 NIL domain; Region: NIL; pfam09383 937773001672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773001673 dimer interface [polypeptide binding]; other site 937773001674 conserved gate region; other site 937773001675 ABC-ATPase subunit interface; other site 937773001676 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 937773001677 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 937773001678 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 937773001679 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 937773001680 Domain of unknown function (DUF368); Region: DUF368; pfam04018 937773001681 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 937773001682 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 937773001683 Walker A/P-loop; other site 937773001684 ATP binding site [chemical binding]; other site 937773001685 Q-loop/lid; other site 937773001686 ABC transporter signature motif; other site 937773001687 Walker B; other site 937773001688 D-loop; other site 937773001689 H-loop/switch region; other site 937773001690 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 937773001691 FeS assembly protein SufD; Region: sufD; TIGR01981 937773001692 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 937773001693 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 937773001694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773001695 catalytic residue [active] 937773001696 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 937773001697 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 937773001698 trimerization site [polypeptide binding]; other site 937773001699 active site 937773001700 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 937773001701 FeS assembly protein SufB; Region: sufB; TIGR01980 937773001702 integrase; Provisional; Region: int; PHA02601 937773001703 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 937773001704 Int/Topo IB signature motif; other site 937773001705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773001706 non-specific DNA binding site [nucleotide binding]; other site 937773001707 salt bridge; other site 937773001708 sequence-specific DNA binding site [nucleotide binding]; other site 937773001709 Predicted transcriptional regulator [Transcription]; Region: COG2932 937773001710 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 937773001711 Catalytic site [active] 937773001712 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 937773001713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773001714 non-specific DNA binding site [nucleotide binding]; other site 937773001715 salt bridge; other site 937773001716 sequence-specific DNA binding site [nucleotide binding]; other site 937773001717 Phage anti-repressor protein [Transcription]; Region: COG3561 937773001718 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 937773001719 ORF6C domain; Region: ORF6C; pfam10552 937773001720 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 937773001721 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 937773001722 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 937773001723 ERF superfamily; Region: ERF; pfam04404 937773001724 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 937773001725 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 937773001726 dimer interface [polypeptide binding]; other site 937773001727 ssDNA binding site [nucleotide binding]; other site 937773001728 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773001729 Protein of unknown function (DUF968); Region: DUF968; pfam06147 937773001730 Helix-turn-helix domain; Region: HTH_36; pfam13730 937773001731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773001732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 937773001733 Walker A motif; other site 937773001734 ATP binding site [chemical binding]; other site 937773001735 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 937773001736 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 937773001737 YopX protein; Region: YopX; pfam09643 937773001738 dUTPase; Region: dUTPase_2; pfam08761 937773001739 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 937773001740 active site 937773001741 homodimer interface [polypeptide binding]; other site 937773001742 metal binding site [ion binding]; metal-binding site 937773001743 Terminase small subunit; Region: Terminase_2; pfam03592 937773001744 Phage terminase large subunit; Region: Terminase_3; cl12054 937773001745 Terminase-like family; Region: Terminase_6; pfam03237 937773001746 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 937773001747 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 937773001748 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 937773001749 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 937773001750 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 937773001751 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 937773001752 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 937773001753 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 937773001754 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 937773001755 Phage protein; Region: DUF3647; pfam12363 937773001756 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 937773001757 Phage-related protein [Function unknown]; Region: COG5412 937773001758 Phage tail protein; Region: Sipho_tail; pfam05709 937773001759 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 937773001760 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 937773001761 active site 937773001762 catalytic triad [active] 937773001763 oxyanion hole [active] 937773001764 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 937773001765 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 937773001766 CHAP domain; Region: CHAP; pfam05257 937773001767 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 937773001768 Lysozyme subfamily 2; Region: LYZ2; smart00047 937773001769 Small integral membrane protein [Function unknown]; Region: COG5546 937773001770 CHAP domain; Region: CHAP; pfam05257 937773001771 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 937773001772 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 937773001773 Domain of unknown function DUF21; Region: DUF21; pfam01595 937773001774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 937773001775 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 937773001776 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 937773001777 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 937773001778 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 937773001779 Protein of unknown function DUF72; Region: DUF72; pfam01904 937773001780 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 937773001781 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 937773001782 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 937773001783 active site 937773001784 metal binding site [ion binding]; metal-binding site 937773001785 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 937773001786 lipoyl synthase; Provisional; Region: PRK05481 937773001787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773001788 FeS/SAM binding site; other site 937773001789 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 937773001790 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 937773001791 Uncharacterized conserved protein [Function unknown]; Region: COG2445 937773001792 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 937773001793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773001794 active site 937773001795 motif I; other site 937773001796 motif II; other site 937773001797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773001798 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 937773001799 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 937773001800 dimerization interface [polypeptide binding]; other site 937773001801 ligand binding site [chemical binding]; other site 937773001802 NADP binding site [chemical binding]; other site 937773001803 catalytic site [active] 937773001804 NifU-like domain; Region: NifU; pfam01106 937773001805 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 937773001806 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 937773001807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773001808 hypothetical protein; Provisional; Region: PRK13669 937773001809 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 937773001810 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 937773001811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773001812 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 937773001813 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 937773001814 interface (dimer of trimers) [polypeptide binding]; other site 937773001815 Substrate-binding/catalytic site; other site 937773001816 Zn-binding sites [ion binding]; other site 937773001817 Predicted permease [General function prediction only]; Region: COG2056 937773001818 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 937773001819 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 937773001820 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 937773001821 CoenzymeA binding site [chemical binding]; other site 937773001822 subunit interaction site [polypeptide binding]; other site 937773001823 PHB binding site; other site 937773001824 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 937773001825 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 937773001826 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 937773001827 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 937773001828 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 937773001829 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 937773001830 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 937773001831 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 937773001832 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 937773001833 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 937773001834 Kinase associated protein B; Region: KapB; pfam08810 937773001835 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 937773001836 active site 937773001837 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 937773001838 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 937773001839 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 937773001840 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 937773001841 DNA-binding site [nucleotide binding]; DNA binding site 937773001842 RNA-binding motif; other site 937773001843 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 937773001844 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 937773001845 RNA binding site [nucleotide binding]; other site 937773001846 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 937773001847 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 937773001848 Glutamate binding site [chemical binding]; other site 937773001849 homodimer interface [polypeptide binding]; other site 937773001850 NAD binding site [chemical binding]; other site 937773001851 catalytic residues [active] 937773001852 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 937773001853 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 937773001854 inhibitor-cofactor binding pocket; inhibition site 937773001855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773001856 catalytic residue [active] 937773001857 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 937773001858 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 937773001859 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 937773001860 NAD(P) binding site [chemical binding]; other site 937773001861 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 937773001862 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 937773001863 active site 937773001864 catalytic site [active] 937773001865 metal binding site [ion binding]; metal-binding site 937773001866 argininosuccinate lyase; Provisional; Region: PRK00855 937773001867 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 937773001868 active sites [active] 937773001869 tetramer interface [polypeptide binding]; other site 937773001870 argininosuccinate synthase; Provisional; Region: PRK13820 937773001871 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 937773001872 ANP binding site [chemical binding]; other site 937773001873 Substrate Binding Site II [chemical binding]; other site 937773001874 Substrate Binding Site I [chemical binding]; other site 937773001875 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 937773001876 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 937773001877 active site 937773001878 dimer interface [polypeptide binding]; other site 937773001879 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 937773001880 dimer interface [polypeptide binding]; other site 937773001881 active site 937773001882 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 937773001883 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 937773001884 Catalytic site [active] 937773001885 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 937773001886 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 937773001887 Catalytic site [active] 937773001888 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 937773001889 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 937773001890 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 937773001891 Part of AAA domain; Region: AAA_19; pfam13245 937773001892 Family description; Region: UvrD_C_2; pfam13538 937773001893 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 937773001894 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 937773001895 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 937773001896 hypothetical protein; Provisional; Region: PRK13673 937773001897 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 937773001898 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 937773001899 putative active site [active] 937773001900 putative NTP binding site [chemical binding]; other site 937773001901 putative nucleic acid binding site [nucleotide binding]; other site 937773001902 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 937773001903 coenzyme A disulfide reductase; Provisional; Region: PRK13512 937773001904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773001905 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 937773001906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773001907 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 937773001908 active site 937773001909 motif I; other site 937773001910 motif II; other site 937773001911 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 937773001912 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 937773001913 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 937773001914 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 937773001915 catalytic triad [active] 937773001916 catalytic triad [active] 937773001917 oxyanion hole [active] 937773001918 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 937773001919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773001920 Walker A motif; other site 937773001921 ATP binding site [chemical binding]; other site 937773001922 Walker B motif; other site 937773001923 arginine finger; other site 937773001924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773001925 Walker A motif; other site 937773001926 ATP binding site [chemical binding]; other site 937773001927 Walker B motif; other site 937773001928 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 937773001929 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 937773001930 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 937773001931 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 937773001932 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 937773001933 dimer interface [polypeptide binding]; other site 937773001934 active site 937773001935 CoA binding pocket [chemical binding]; other site 937773001936 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 937773001937 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 937773001938 dimer interface [polypeptide binding]; other site 937773001939 active site 937773001940 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 937773001941 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 937773001942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773001943 dimer interface [polypeptide binding]; other site 937773001944 conserved gate region; other site 937773001945 putative PBP binding loops; other site 937773001946 ABC-ATPase subunit interface; other site 937773001947 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 937773001948 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 937773001949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773001950 dimer interface [polypeptide binding]; other site 937773001951 conserved gate region; other site 937773001952 putative PBP binding loops; other site 937773001953 ABC-ATPase subunit interface; other site 937773001954 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 937773001955 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 937773001956 Walker A/P-loop; other site 937773001957 ATP binding site [chemical binding]; other site 937773001958 Q-loop/lid; other site 937773001959 ABC transporter signature motif; other site 937773001960 Walker B; other site 937773001961 D-loop; other site 937773001962 H-loop/switch region; other site 937773001963 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 937773001964 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 937773001965 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 937773001966 Walker A/P-loop; other site 937773001967 ATP binding site [chemical binding]; other site 937773001968 Q-loop/lid; other site 937773001969 ABC transporter signature motif; other site 937773001970 Walker B; other site 937773001971 D-loop; other site 937773001972 H-loop/switch region; other site 937773001973 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 937773001974 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 937773001975 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 937773001976 peptide binding site [polypeptide binding]; other site 937773001977 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 937773001978 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 937773001979 active site 937773001980 HIGH motif; other site 937773001981 dimer interface [polypeptide binding]; other site 937773001982 KMSKS motif; other site 937773001983 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 937773001984 ArsC family; Region: ArsC; pfam03960 937773001985 putative catalytic residues [active] 937773001986 thiol/disulfide switch; other site 937773001987 adaptor protein; Provisional; Region: PRK02315 937773001988 potential frameshift: common BLAST hit: gi|150395106|ref|YP_001317781.1| peptidase S1 and S6 chymotrypsin/Hap 937773001989 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 937773001990 Competence protein CoiA-like family; Region: CoiA; cl11541 937773001991 oligoendopeptidase F; Region: pepF; TIGR00181 937773001992 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 937773001993 active site 937773001994 Zn binding site [ion binding]; other site 937773001995 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 937773001996 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 937773001997 Thioredoxin; Region: Thioredoxin_5; pfam13743 937773001998 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 937773001999 apolar tunnel; other site 937773002000 heme binding site [chemical binding]; other site 937773002001 dimerization interface [polypeptide binding]; other site 937773002002 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 937773002003 putative active site [active] 937773002004 putative metal binding residues [ion binding]; other site 937773002005 signature motif; other site 937773002006 putative triphosphate binding site [ion binding]; other site 937773002007 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 937773002008 synthetase active site [active] 937773002009 NTP binding site [chemical binding]; other site 937773002010 metal binding site [ion binding]; metal-binding site 937773002011 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 937773002012 ATP-NAD kinase; Region: NAD_kinase; pfam01513 937773002013 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 937773002014 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 937773002015 active site 937773002016 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 937773002017 MgtE intracellular N domain; Region: MgtE_N; smart00924 937773002018 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 937773002019 Divalent cation transporter; Region: MgtE; pfam01769 937773002020 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 937773002021 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 937773002022 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 937773002023 TrkA-N domain; Region: TrkA_N; pfam02254 937773002024 TrkA-C domain; Region: TrkA_C; pfam02080 937773002025 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 937773002026 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 937773002027 NAD binding site [chemical binding]; other site 937773002028 homotetramer interface [polypeptide binding]; other site 937773002029 homodimer interface [polypeptide binding]; other site 937773002030 substrate binding site [chemical binding]; other site 937773002031 active site 937773002032 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 937773002033 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 937773002034 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 937773002035 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 937773002036 MFS/sugar transport protein; Region: MFS_2; pfam13347 937773002037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773002038 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 937773002039 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 937773002040 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 937773002041 Asp-box motif; other site 937773002042 catalytic site [active] 937773002043 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 937773002044 Domain of unknown function DUF20; Region: UPF0118; pfam01594 937773002045 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 937773002046 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 937773002047 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 937773002048 Putative esterase; Region: Esterase; pfam00756 937773002049 hypothetical protein; Provisional; Region: PRK13679 937773002050 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 937773002051 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 937773002052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773002053 Walker A/P-loop; other site 937773002054 ATP binding site [chemical binding]; other site 937773002055 Q-loop/lid; other site 937773002056 ABC transporter signature motif; other site 937773002057 Walker B; other site 937773002058 D-loop; other site 937773002059 H-loop/switch region; other site 937773002060 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 937773002061 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 937773002062 putative active site [active] 937773002063 putative NTP binding site [chemical binding]; other site 937773002064 putative nucleic acid binding site [nucleotide binding]; other site 937773002065 CAAX protease self-immunity; Region: Abi; pfam02517 937773002066 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 937773002067 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 937773002068 Sulfatase; Region: Sulfatase; cl17466 937773002069 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 937773002070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773002071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773002072 putative substrate translocation pore; other site 937773002073 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 937773002074 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 937773002075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 937773002076 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 937773002077 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 937773002078 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773002079 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773002080 YueH-like protein; Region: YueH; pfam14166 937773002081 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 937773002082 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 937773002083 G1 box; other site 937773002084 putative GEF interaction site [polypeptide binding]; other site 937773002085 GTP/Mg2+ binding site [chemical binding]; other site 937773002086 Switch I region; other site 937773002087 G2 box; other site 937773002088 G3 box; other site 937773002089 Switch II region; other site 937773002090 G4 box; other site 937773002091 G5 box; other site 937773002092 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 937773002093 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 937773002094 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 937773002095 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 937773002096 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 937773002097 protein binding site [polypeptide binding]; other site 937773002098 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 937773002099 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 937773002100 potential frameshift: common BLAST hit: gi|73663149|ref|YP_301930.1| poly D-alanine transfer protein 937773002101 DltD central region; Region: DltD_M; pfam04918 937773002102 DltD C-terminal region; Region: DltD_C; pfam04914 937773002103 DltD N-terminal region; Region: DltD_N; pfam04915 937773002104 DltD central region; Region: DltD_M; pfam04918 937773002105 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 937773002106 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 937773002107 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 937773002108 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 937773002109 acyl-activating enzyme (AAE) consensus motif; other site 937773002110 AMP binding site [chemical binding]; other site 937773002111 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 937773002112 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 937773002113 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 937773002114 active site 937773002115 metal binding site [ion binding]; metal-binding site 937773002116 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 937773002117 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 937773002118 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 937773002119 Cna protein B-type domain; Region: Cna_B; pfam05738 937773002120 Cna protein B-type domain; Region: Cna_B; pfam05738 937773002121 Cna protein B-type domain; Region: Cna_B; pfam05738 937773002122 Cna protein B-type domain; Region: Cna_B; pfam05738 937773002123 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 937773002124 ComK protein; Region: ComK; cl11560 937773002125 A short protein domain of unknown function; Region: IDEAL; smart00914 937773002126 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 937773002127 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 937773002128 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 937773002129 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 937773002130 YolD-like protein; Region: YolD; pfam08863 937773002131 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 937773002132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773002133 Coenzyme A binding pocket [chemical binding]; other site 937773002134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 937773002135 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 937773002136 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 937773002137 Walker A/P-loop; other site 937773002138 ATP binding site [chemical binding]; other site 937773002139 Q-loop/lid; other site 937773002140 ABC transporter signature motif; other site 937773002141 Walker B; other site 937773002142 D-loop; other site 937773002143 H-loop/switch region; other site 937773002144 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 937773002145 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 937773002146 UbiA prenyltransferase family; Region: UbiA; pfam01040 937773002147 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 937773002148 chorismate binding enzyme; Region: Chorismate_bind; cl10555 937773002149 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 937773002150 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 937773002151 dimer interface [polypeptide binding]; other site 937773002152 tetramer interface [polypeptide binding]; other site 937773002153 PYR/PP interface [polypeptide binding]; other site 937773002154 TPP binding site [chemical binding]; other site 937773002155 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 937773002156 TPP-binding site; other site 937773002157 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 937773002158 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 937773002159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 937773002160 substrate binding site [chemical binding]; other site 937773002161 oxyanion hole (OAH) forming residues; other site 937773002162 trimer interface [polypeptide binding]; other site 937773002163 aminotransferase A; Validated; Region: PRK07683 937773002164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773002165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773002166 homodimer interface [polypeptide binding]; other site 937773002167 catalytic residue [active] 937773002168 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 937773002169 Acyltransferase family; Region: Acyl_transf_3; pfam01757 937773002170 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 937773002171 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 937773002172 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 937773002173 active site 937773002174 catalytic triad [active] 937773002175 oxyanion hole [active] 937773002176 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 937773002177 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 937773002178 amidase catalytic site [active] 937773002179 Zn binding residues [ion binding]; other site 937773002180 substrate binding site [chemical binding]; other site 937773002181 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 937773002182 Lysozyme subfamily 2; Region: LYZ2; smart00047 937773002183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773002184 Coenzyme A binding pocket [chemical binding]; other site 937773002185 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 937773002186 Transcriptional regulator [Transcription]; Region: LytR; COG1316 937773002187 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 937773002188 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 937773002189 active site 937773002190 substrate binding site [chemical binding]; other site 937773002191 metal binding site [ion binding]; metal-binding site 937773002192 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 937773002193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773002194 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 937773002195 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 937773002196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 937773002197 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 937773002198 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 937773002199 active site 937773002200 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 937773002201 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 937773002202 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 937773002203 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 937773002204 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 937773002205 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 937773002206 Walker A/P-loop; other site 937773002207 ATP binding site [chemical binding]; other site 937773002208 Q-loop/lid; other site 937773002209 ABC transporter signature motif; other site 937773002210 Walker B; other site 937773002211 D-loop; other site 937773002212 H-loop/switch region; other site 937773002213 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 937773002214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 937773002215 Predicted membrane protein [Function unknown]; Region: COG3212 937773002216 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 937773002217 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 937773002218 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 937773002219 active site 937773002220 tetramer interface [polypeptide binding]; other site 937773002221 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 937773002222 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 937773002223 Subunit I/III interface [polypeptide binding]; other site 937773002224 Subunit III/IV interface [polypeptide binding]; other site 937773002225 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 937773002226 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 937773002227 D-pathway; other site 937773002228 Putative ubiquinol binding site [chemical binding]; other site 937773002229 Low-spin heme (heme b) binding site [chemical binding]; other site 937773002230 Putative water exit pathway; other site 937773002231 Binuclear center (heme o3/CuB) [ion binding]; other site 937773002232 K-pathway; other site 937773002233 Putative proton exit pathway; other site 937773002234 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 937773002235 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 937773002236 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 937773002237 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 937773002238 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 937773002239 heme-binding site [chemical binding]; other site 937773002240 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 937773002241 FAD binding pocket [chemical binding]; other site 937773002242 FAD binding motif [chemical binding]; other site 937773002243 phosphate binding motif [ion binding]; other site 937773002244 beta-alpha-beta structure motif; other site 937773002245 NAD binding pocket [chemical binding]; other site 937773002246 Heme binding pocket [chemical binding]; other site 937773002247 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 937773002248 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 937773002249 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 937773002250 homodimer interface [polypeptide binding]; other site 937773002251 NADP binding site [chemical binding]; other site 937773002252 substrate binding site [chemical binding]; other site 937773002253 AIR carboxylase; Region: AIRC; pfam00731 937773002254 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 937773002255 ATP-grasp domain; Region: ATP-grasp; pfam02222 937773002256 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 937773002257 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 937773002258 ATP binding site [chemical binding]; other site 937773002259 active site 937773002260 substrate binding site [chemical binding]; other site 937773002261 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 937773002262 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 937773002263 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 937773002264 putative active site [active] 937773002265 catalytic triad [active] 937773002266 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 937773002267 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 937773002268 dimerization interface [polypeptide binding]; other site 937773002269 ATP binding site [chemical binding]; other site 937773002270 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 937773002271 dimerization interface [polypeptide binding]; other site 937773002272 ATP binding site [chemical binding]; other site 937773002273 amidophosphoribosyltransferase; Provisional; Region: PRK07272 937773002274 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 937773002275 active site 937773002276 tetramer interface [polypeptide binding]; other site 937773002277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773002278 active site 937773002279 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 937773002280 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 937773002281 dimerization interface [polypeptide binding]; other site 937773002282 putative ATP binding site [chemical binding]; other site 937773002283 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 937773002284 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 937773002285 active site 937773002286 substrate binding site [chemical binding]; other site 937773002287 cosubstrate binding site; other site 937773002288 catalytic site [active] 937773002289 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 937773002290 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 937773002291 purine monophosphate binding site [chemical binding]; other site 937773002292 dimer interface [polypeptide binding]; other site 937773002293 putative catalytic residues [active] 937773002294 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 937773002295 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 937773002296 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 937773002297 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 937773002298 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 937773002299 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 937773002300 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 937773002301 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 937773002302 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 937773002303 Walker A/P-loop; other site 937773002304 ATP binding site [chemical binding]; other site 937773002305 Q-loop/lid; other site 937773002306 ABC transporter signature motif; other site 937773002307 Walker B; other site 937773002308 D-loop; other site 937773002309 H-loop/switch region; other site 937773002310 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 937773002311 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 937773002312 Walker A/P-loop; other site 937773002313 ATP binding site [chemical binding]; other site 937773002314 Q-loop/lid; other site 937773002315 ABC transporter signature motif; other site 937773002316 Walker B; other site 937773002317 D-loop; other site 937773002318 H-loop/switch region; other site 937773002319 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 937773002320 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 937773002321 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 937773002322 putative RNA binding site [nucleotide binding]; other site 937773002323 Methyltransferase domain; Region: Methyltransf_26; pfam13659 937773002324 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 937773002325 dimerization domain swap beta strand [polypeptide binding]; other site 937773002326 regulatory protein interface [polypeptide binding]; other site 937773002327 active site 937773002328 regulatory phosphorylation site [posttranslational modification]; other site 937773002329 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 937773002330 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 937773002331 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 937773002332 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 937773002333 Transposase; Region: DEDD_Tnp_IS110; pfam01548 937773002334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 937773002335 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 937773002336 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 937773002337 catalytic residues [active] 937773002338 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 937773002339 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 937773002340 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 937773002341 TrkA-N domain; Region: TrkA_N; pfam02254 937773002342 TrkA-C domain; Region: TrkA_C; pfam02080 937773002343 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 937773002344 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 937773002345 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 937773002346 hypothetical protein; Provisional; Region: PRK13667 937773002347 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 937773002348 active site 937773002349 catalytic residues [active] 937773002350 metal binding site [ion binding]; metal-binding site 937773002351 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 937773002352 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 937773002353 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 937773002354 TPP-binding site [chemical binding]; other site 937773002355 tetramer interface [polypeptide binding]; other site 937773002356 heterodimer interface [polypeptide binding]; other site 937773002357 phosphorylation loop region [posttranslational modification] 937773002358 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 937773002359 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 937773002360 alpha subunit interface [polypeptide binding]; other site 937773002361 TPP binding site [chemical binding]; other site 937773002362 heterodimer interface [polypeptide binding]; other site 937773002363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 937773002364 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 937773002365 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 937773002366 E3 interaction surface; other site 937773002367 lipoyl attachment site [posttranslational modification]; other site 937773002368 e3 binding domain; Region: E3_binding; pfam02817 937773002369 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 937773002370 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 937773002371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 937773002372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773002373 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 937773002374 hypothetical protein; Provisional; Region: PRK04387 937773002375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 937773002376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773002377 non-specific DNA binding site [nucleotide binding]; other site 937773002378 salt bridge; other site 937773002379 sequence-specific DNA binding site [nucleotide binding]; other site 937773002380 Cupin domain; Region: Cupin_2; pfam07883 937773002381 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 937773002382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773002383 Walker A/P-loop; other site 937773002384 ATP binding site [chemical binding]; other site 937773002385 Q-loop/lid; other site 937773002386 ABC transporter signature motif; other site 937773002387 Walker B; other site 937773002388 D-loop; other site 937773002389 H-loop/switch region; other site 937773002390 TOBE domain; Region: TOBE_2; pfam08402 937773002391 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 937773002392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773002393 dimer interface [polypeptide binding]; other site 937773002394 conserved gate region; other site 937773002395 putative PBP binding loops; other site 937773002396 ABC-ATPase subunit interface; other site 937773002397 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 937773002398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773002399 ABC-ATPase subunit interface; other site 937773002400 putative PBP binding loops; other site 937773002401 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 937773002402 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 937773002403 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 937773002404 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 937773002405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 937773002406 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 937773002407 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 937773002408 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 937773002409 active site 937773002410 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 937773002411 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 937773002412 G1 box; other site 937773002413 putative GEF interaction site [polypeptide binding]; other site 937773002414 GTP/Mg2+ binding site [chemical binding]; other site 937773002415 Switch I region; other site 937773002416 G2 box; other site 937773002417 G3 box; other site 937773002418 Switch II region; other site 937773002419 G4 box; other site 937773002420 G5 box; other site 937773002421 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 937773002422 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 937773002423 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 937773002424 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 937773002425 putative active site [active] 937773002426 putative FMN binding site [chemical binding]; other site 937773002427 putative substrate binding site [chemical binding]; other site 937773002428 putative catalytic residue [active] 937773002429 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 937773002430 hypothetical protein; Provisional; Region: PRK13666 937773002431 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 937773002432 pyruvate carboxylase; Reviewed; Region: PRK12999 937773002433 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773002434 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 937773002435 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 937773002436 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 937773002437 active site 937773002438 catalytic residues [active] 937773002439 metal binding site [ion binding]; metal-binding site 937773002440 homodimer binding site [polypeptide binding]; other site 937773002441 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 937773002442 carboxyltransferase (CT) interaction site; other site 937773002443 biotinylation site [posttranslational modification]; other site 937773002444 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 937773002445 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 937773002446 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 937773002447 UbiA prenyltransferase family; Region: UbiA; pfam01040 937773002448 Protein of unknown function (DUF420); Region: DUF420; pfam04238 937773002449 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 937773002450 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 937773002451 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 937773002452 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 937773002453 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 937773002454 putative active site [active] 937773002455 catalytic site [active] 937773002456 putative metal binding site [ion binding]; other site 937773002457 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 937773002458 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 937773002459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773002460 S-adenosylmethionine binding site [chemical binding]; other site 937773002461 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 937773002462 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 937773002463 active site 937773002464 (T/H)XGH motif; other site 937773002465 hypothetical protein; Provisional; Region: PRK13670 937773002466 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 937773002467 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 937773002468 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 937773002469 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 937773002470 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 937773002471 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 937773002472 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 937773002473 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 937773002474 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 937773002475 dimer interface [polypeptide binding]; other site 937773002476 motif 1; other site 937773002477 active site 937773002478 motif 2; other site 937773002479 motif 3; other site 937773002480 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 937773002481 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 937773002482 putative tRNA-binding site [nucleotide binding]; other site 937773002483 B3/4 domain; Region: B3_4; pfam03483 937773002484 tRNA synthetase B5 domain; Region: B5; smart00874 937773002485 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 937773002486 dimer interface [polypeptide binding]; other site 937773002487 motif 1; other site 937773002488 motif 3; other site 937773002489 motif 2; other site 937773002490 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 937773002491 Alkylmercury lyase; Region: MerB; pfam03243 937773002492 ribonuclease HIII; Provisional; Region: PRK00996 937773002493 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 937773002494 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 937773002495 RNA/DNA hybrid binding site [nucleotide binding]; other site 937773002496 active site 937773002497 Cell division protein ZapA; Region: ZapA; cl01146 937773002498 Colicin V production protein; Region: Colicin_V; pfam02674 937773002499 hypothetical protein; Provisional; Region: PRK08609 937773002500 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 937773002501 active site 937773002502 primer binding site [nucleotide binding]; other site 937773002503 NTP binding site [chemical binding]; other site 937773002504 metal binding triad [ion binding]; metal-binding site 937773002505 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 937773002506 active site 937773002507 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 937773002508 MutS domain III; Region: MutS_III; pfam05192 937773002509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773002510 Walker A/P-loop; other site 937773002511 ATP binding site [chemical binding]; other site 937773002512 Q-loop/lid; other site 937773002513 ABC transporter signature motif; other site 937773002514 Walker B; other site 937773002515 D-loop; other site 937773002516 H-loop/switch region; other site 937773002517 Smr domain; Region: Smr; pfam01713 937773002518 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773002519 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 937773002520 catalytic residues [active] 937773002521 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 937773002522 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 937773002523 GIY-YIG motif/motif A; other site 937773002524 active site 937773002525 catalytic site [active] 937773002526 putative DNA binding site [nucleotide binding]; other site 937773002527 metal binding site [ion binding]; metal-binding site 937773002528 UvrB/uvrC motif; Region: UVR; pfam02151 937773002529 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 937773002530 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 937773002531 putative Iron-sulfur protein interface [polypeptide binding]; other site 937773002532 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 937773002533 proximal heme binding site [chemical binding]; other site 937773002534 distal heme binding site [chemical binding]; other site 937773002535 putative dimer interface [polypeptide binding]; other site 937773002536 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 937773002537 L-aspartate oxidase; Provisional; Region: PRK06175 937773002538 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 937773002539 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 937773002540 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 937773002541 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 937773002542 glutamate racemase; Provisional; Region: PRK00865 937773002543 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 937773002544 active site 937773002545 dimerization interface [polypeptide binding]; other site 937773002546 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 937773002547 active site 937773002548 metal binding site [ion binding]; metal-binding site 937773002549 homotetramer interface [polypeptide binding]; other site 937773002550 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 937773002551 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 937773002552 catalytic residues [active] 937773002553 catalytic nucleophile [active] 937773002554 Presynaptic Site I dimer interface [polypeptide binding]; other site 937773002555 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 937773002556 Synaptic Flat tetramer interface [polypeptide binding]; other site 937773002557 Synaptic Site I dimer interface [polypeptide binding]; other site 937773002558 DNA binding site [nucleotide binding] 937773002559 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 937773002560 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773002561 Soluble P-type ATPase [General function prediction only]; Region: COG4087 937773002562 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 937773002563 metal-binding site [ion binding] 937773002564 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 937773002565 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 937773002566 dimerization interface [polypeptide binding]; other site 937773002567 DPS ferroxidase diiron center [ion binding]; other site 937773002568 ion pore; other site 937773002569 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 937773002570 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 937773002571 ligand binding site [chemical binding]; other site 937773002572 flexible hinge region; other site 937773002573 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 937773002574 putative switch regulator; other site 937773002575 non-specific DNA interactions [nucleotide binding]; other site 937773002576 DNA binding site [nucleotide binding] 937773002577 sequence specific DNA binding site [nucleotide binding]; other site 937773002578 putative cAMP binding site [chemical binding]; other site 937773002579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 937773002580 Integrase core domain; Region: rve; pfam00665 937773002581 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 937773002582 dimer interface [polypeptide binding]; other site 937773002583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 937773002584 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 937773002585 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 937773002586 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 937773002587 dUMP phosphatase; Provisional; Region: PRK09449 937773002588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773002589 motif II; other site 937773002590 hypothetical protein; Provisional; Region: PRK13688 937773002591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773002592 Coenzyme A binding pocket [chemical binding]; other site 937773002593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 937773002594 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 937773002595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 937773002596 MraZ protein; Region: MraZ; pfam02381 937773002597 MraZ protein; Region: MraZ; pfam02381 937773002598 MraW methylase family; Region: Methyltransf_5; pfam01795 937773002599 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 937773002600 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 937773002601 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 937773002602 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 937773002603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 937773002604 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 937773002605 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 937773002606 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 937773002607 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 937773002608 Mg++ binding site [ion binding]; other site 937773002609 putative catalytic motif [active] 937773002610 putative substrate binding site [chemical binding]; other site 937773002611 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 937773002612 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 937773002613 NAD binding site [chemical binding]; other site 937773002614 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773002615 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773002616 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 937773002617 Cell division protein FtsQ; Region: FtsQ; pfam03799 937773002618 cell division protein FtsA; Region: ftsA; TIGR01174 937773002619 Cell division protein FtsA; Region: FtsA; smart00842 937773002620 Cell division protein FtsA; Region: FtsA; pfam14450 937773002621 cell division protein FtsZ; Validated; Region: PRK09330 937773002622 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 937773002623 nucleotide binding site [chemical binding]; other site 937773002624 SulA interaction site; other site 937773002625 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 937773002626 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 937773002627 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 937773002628 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773002629 catalytic residue [active] 937773002630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 937773002631 YGGT family; Region: YGGT; pfam02325 937773002632 D-ribose pyranase; Provisional; Region: PRK11797 937773002633 Sugar transport protein; Region: Sugar_transport; pfam06800 937773002634 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 937773002635 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 937773002636 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 937773002637 putative active site [active] 937773002638 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 937773002639 Class I aldolases; Region: Aldolase_Class_I; cl17187 937773002640 catalytic residue [active] 937773002641 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 937773002642 Na binding site [ion binding]; other site 937773002643 Domain of unknown function (DUF386); Region: DUF386; cl01047 937773002644 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 937773002645 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773002646 RNA binding surface [nucleotide binding]; other site 937773002647 DivIVA protein; Region: DivIVA; pfam05103 937773002648 DivIVA domain; Region: DivI1A_domain; TIGR03544 937773002649 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 937773002650 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 937773002651 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 937773002652 HIGH motif; other site 937773002653 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 937773002654 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 937773002655 active site 937773002656 KMSKS motif; other site 937773002657 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 937773002658 tRNA binding surface [nucleotide binding]; other site 937773002659 anticodon binding site; other site 937773002660 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 937773002661 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 937773002662 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 937773002663 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773002664 RNA binding surface [nucleotide binding]; other site 937773002665 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 937773002666 active site 937773002667 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 937773002668 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773002669 active site 937773002670 uracil transporter; Provisional; Region: PRK10720 937773002671 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 937773002672 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 937773002673 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 937773002674 dihydroorotase; Validated; Region: pyrC; PRK09357 937773002675 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 937773002676 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 937773002677 active site 937773002678 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 937773002679 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 937773002680 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 937773002681 catalytic site [active] 937773002682 subunit interface [polypeptide binding]; other site 937773002683 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 937773002684 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773002685 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 937773002686 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 937773002687 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773002688 ATP-grasp domain; Region: ATP-grasp_4; cl17255 937773002689 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 937773002690 IMP binding site; other site 937773002691 dimer interface [polypeptide binding]; other site 937773002692 interdomain contacts; other site 937773002693 partial ornithine binding site; other site 937773002694 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 937773002695 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 937773002696 FAD binding pocket [chemical binding]; other site 937773002697 FAD binding motif [chemical binding]; other site 937773002698 phosphate binding motif [ion binding]; other site 937773002699 beta-alpha-beta structure motif; other site 937773002700 NAD binding pocket [chemical binding]; other site 937773002701 Iron coordination center [ion binding]; other site 937773002702 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 937773002703 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 937773002704 heterodimer interface [polypeptide binding]; other site 937773002705 active site 937773002706 FMN binding site [chemical binding]; other site 937773002707 homodimer interface [polypeptide binding]; other site 937773002708 substrate binding site [chemical binding]; other site 937773002709 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 937773002710 active site 937773002711 dimer interface [polypeptide binding]; other site 937773002712 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773002713 active site 937773002714 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 937773002715 dimer interface [polypeptide binding]; other site 937773002716 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 937773002717 Domain of unknown function (DUF814); Region: DUF814; pfam05670 937773002718 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 937773002719 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 937773002720 catalytic site [active] 937773002721 G-X2-G-X-G-K; other site 937773002722 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 937773002723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773002724 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 937773002725 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 937773002726 active site 937773002727 ATP binding site [chemical binding]; other site 937773002728 substrate binding site [chemical binding]; other site 937773002729 activation loop (A-loop); other site 937773002730 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 937773002731 Flavoprotein; Region: Flavoprotein; pfam02441 937773002732 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 937773002733 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 937773002734 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773002735 ATP binding site [chemical binding]; other site 937773002736 putative Mg++ binding site [ion binding]; other site 937773002737 helicase superfamily c-terminal domain; Region: HELICc; smart00490 937773002738 nucleotide binding region [chemical binding]; other site 937773002739 ATP-binding site [chemical binding]; other site 937773002740 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 937773002741 active site 937773002742 catalytic residues [active] 937773002743 metal binding site [ion binding]; metal-binding site 937773002744 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 937773002745 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 937773002746 putative active site [active] 937773002747 substrate binding site [chemical binding]; other site 937773002748 putative cosubstrate binding site; other site 937773002749 catalytic site [active] 937773002750 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 937773002751 substrate binding site [chemical binding]; other site 937773002752 16S rRNA methyltransferase B; Provisional; Region: PRK14902 937773002753 NusB family; Region: NusB; pfam01029 937773002754 putative RNA binding site [nucleotide binding]; other site 937773002755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773002756 S-adenosylmethionine binding site [chemical binding]; other site 937773002757 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 937773002758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773002759 FeS/SAM binding site; other site 937773002760 Protein phosphatase 2C; Region: PP2C; pfam00481 937773002761 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 937773002762 active site 937773002763 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 937773002764 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 937773002765 active site 937773002766 ATP binding site [chemical binding]; other site 937773002767 substrate binding site [chemical binding]; other site 937773002768 activation loop (A-loop); other site 937773002769 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 937773002770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 937773002771 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 937773002772 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 937773002773 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 937773002774 Cytochrome P450; Region: p450; cl12078 937773002775 Transposase; Region: DEDD_Tnp_IS110; pfam01548 937773002776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 937773002777 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 937773002778 GTPase RsgA; Reviewed; Region: PRK00098 937773002779 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 937773002780 RNA binding site [nucleotide binding]; other site 937773002781 homodimer interface [polypeptide binding]; other site 937773002782 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 937773002783 GTPase/Zn-binding domain interface [polypeptide binding]; other site 937773002784 GTP/Mg2+ binding site [chemical binding]; other site 937773002785 G4 box; other site 937773002786 G5 box; other site 937773002787 G1 box; other site 937773002788 Switch I region; other site 937773002789 G2 box; other site 937773002790 G3 box; other site 937773002791 Switch II region; other site 937773002792 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 937773002793 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 937773002794 substrate binding site [chemical binding]; other site 937773002795 hexamer interface [polypeptide binding]; other site 937773002796 metal binding site [ion binding]; metal-binding site 937773002797 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 937773002798 Thiamine pyrophosphokinase; Region: TPK; cd07995 937773002799 active site 937773002800 dimerization interface [polypeptide binding]; other site 937773002801 thiamine binding site [chemical binding]; other site 937773002802 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 937773002803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 937773002804 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 937773002805 DAK2 domain; Region: Dak2; pfam02734 937773002806 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 937773002807 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 937773002808 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 937773002809 putative L-serine binding site [chemical binding]; other site 937773002810 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 937773002811 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 937773002812 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 937773002813 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 937773002814 generic binding surface II; other site 937773002815 ssDNA binding site; other site 937773002816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773002817 ATP binding site [chemical binding]; other site 937773002818 putative Mg++ binding site [ion binding]; other site 937773002819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773002820 nucleotide binding region [chemical binding]; other site 937773002821 ATP-binding site [chemical binding]; other site 937773002822 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 937773002823 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 937773002824 active site 2 [active] 937773002825 active site 1 [active] 937773002826 putative phosphate acyltransferase; Provisional; Region: PRK05331 937773002827 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 937773002828 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 937773002829 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 937773002830 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 937773002831 NAD(P) binding site [chemical binding]; other site 937773002832 homotetramer interface [polypeptide binding]; other site 937773002833 homodimer interface [polypeptide binding]; other site 937773002834 active site 937773002835 acyl carrier protein; Provisional; Region: acpP; PRK00982 937773002836 ribonuclease III; Reviewed; Region: rnc; PRK00102 937773002837 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 937773002838 dimerization interface [polypeptide binding]; other site 937773002839 active site 937773002840 metal binding site [ion binding]; metal-binding site 937773002841 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 937773002842 dsRNA binding site [nucleotide binding]; other site 937773002843 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 937773002844 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 937773002845 Walker A/P-loop; other site 937773002846 ATP binding site [chemical binding]; other site 937773002847 Q-loop/lid; other site 937773002848 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 937773002849 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 937773002850 ABC transporter signature motif; other site 937773002851 Walker B; other site 937773002852 D-loop; other site 937773002853 H-loop/switch region; other site 937773002854 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 937773002855 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 937773002856 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 937773002857 P loop; other site 937773002858 GTP binding site [chemical binding]; other site 937773002859 putative DNA-binding protein; Validated; Region: PRK00118 937773002860 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 937773002861 signal recognition particle protein; Provisional; Region: PRK10867 937773002862 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 937773002863 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 937773002864 P loop; other site 937773002865 GTP binding site [chemical binding]; other site 937773002866 Signal peptide binding domain; Region: SRP_SPB; pfam02978 937773002867 putative transposase OrfB; Reviewed; Region: PHA02517 937773002868 HTH-like domain; Region: HTH_21; pfam13276 937773002869 Integrase core domain; Region: rve; pfam00665 937773002870 Integrase core domain; Region: rve_3; pfam13683 937773002871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 937773002872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773002873 non-specific DNA binding site [nucleotide binding]; other site 937773002874 salt bridge; other site 937773002875 sequence-specific DNA binding site [nucleotide binding]; other site 937773002876 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 937773002877 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 937773002878 putative active site; other site 937773002879 putative metal binding residues [ion binding]; other site 937773002880 signature motif; other site 937773002881 putative triphosphate binding site [ion binding]; other site 937773002882 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 937773002883 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 937773002884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773002885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773002886 putative substrate translocation pore; other site 937773002887 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773002888 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 937773002889 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 937773002890 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 937773002891 RimM N-terminal domain; Region: RimM; pfam01782 937773002892 PRC-barrel domain; Region: PRC; pfam05239 937773002893 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 937773002894 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 937773002895 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 937773002896 Predicted membrane protein [Function unknown]; Region: COG4485 937773002897 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 937773002898 Predicted membrane protein [Function unknown]; Region: COG2246 937773002899 GtrA-like protein; Region: GtrA; pfam04138 937773002900 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 937773002901 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 937773002902 GTP/Mg2+ binding site [chemical binding]; other site 937773002903 G4 box; other site 937773002904 G5 box; other site 937773002905 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 937773002906 G1 box; other site 937773002907 G1 box; other site 937773002908 GTP/Mg2+ binding site [chemical binding]; other site 937773002909 Switch I region; other site 937773002910 G2 box; other site 937773002911 G2 box; other site 937773002912 G3 box; other site 937773002913 G3 box; other site 937773002914 Switch II region; other site 937773002915 Switch II region; other site 937773002916 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 937773002917 RNA/DNA hybrid binding site [nucleotide binding]; other site 937773002918 active site 937773002919 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 937773002920 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 937773002921 CoA-ligase; Region: Ligase_CoA; pfam00549 937773002922 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 937773002923 CoA binding domain; Region: CoA_binding; smart00881 937773002924 CoA-ligase; Region: Ligase_CoA; pfam00549 937773002925 DNA protecting protein DprA; Region: dprA; TIGR00732 937773002926 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 937773002927 DNA topoisomerase I; Validated; Region: PRK05582 937773002928 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 937773002929 active site 937773002930 interdomain interaction site; other site 937773002931 putative metal-binding site [ion binding]; other site 937773002932 nucleotide binding site [chemical binding]; other site 937773002933 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 937773002934 domain I; other site 937773002935 DNA binding groove [nucleotide binding] 937773002936 phosphate binding site [ion binding]; other site 937773002937 domain II; other site 937773002938 domain III; other site 937773002939 nucleotide binding site [chemical binding]; other site 937773002940 catalytic site [active] 937773002941 domain IV; other site 937773002942 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 937773002943 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 937773002944 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 937773002945 Glucose inhibited division protein A; Region: GIDA; pfam01134 937773002946 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 937773002947 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 937773002948 active site 937773002949 DNA binding site [nucleotide binding] 937773002950 Int/Topo IB signature motif; other site 937773002951 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 937773002952 active site 937773002953 HslU subunit interaction site [polypeptide binding]; other site 937773002954 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 937773002955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773002956 Walker A motif; other site 937773002957 ATP binding site [chemical binding]; other site 937773002958 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 937773002959 Walker B motif; other site 937773002960 arginine finger; other site 937773002961 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 937773002962 transcriptional repressor CodY; Validated; Region: PRK04158 937773002963 CodY GAF-like domain; Region: CodY; pfam06018 937773002964 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 937773002965 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 937773002966 rRNA interaction site [nucleotide binding]; other site 937773002967 S8 interaction site; other site 937773002968 putative laminin-1 binding site; other site 937773002969 elongation factor Ts; Provisional; Region: tsf; PRK09377 937773002970 UBA/TS-N domain; Region: UBA; pfam00627 937773002971 Elongation factor TS; Region: EF_TS; pfam00889 937773002972 Elongation factor TS; Region: EF_TS; pfam00889 937773002973 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 937773002974 putative nucleotide binding site [chemical binding]; other site 937773002975 uridine monophosphate binding site [chemical binding]; other site 937773002976 homohexameric interface [polypeptide binding]; other site 937773002977 ribosome recycling factor; Reviewed; Region: frr; PRK00083 937773002978 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 937773002979 hinge region; other site 937773002980 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 937773002981 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 937773002982 catalytic residue [active] 937773002983 putative FPP diphosphate binding site; other site 937773002984 putative FPP binding hydrophobic cleft; other site 937773002985 dimer interface [polypeptide binding]; other site 937773002986 putative IPP diphosphate binding site; other site 937773002987 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 937773002988 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 937773002989 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 937773002990 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 937773002991 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 937773002992 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 937773002993 RIP metalloprotease RseP; Region: TIGR00054 937773002994 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 937773002995 active site 937773002996 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 937773002997 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 937773002998 protein binding site [polypeptide binding]; other site 937773002999 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 937773003000 putative substrate binding region [chemical binding]; other site 937773003001 prolyl-tRNA synthetase; Provisional; Region: PRK09194 937773003002 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 937773003003 dimer interface [polypeptide binding]; other site 937773003004 motif 1; other site 937773003005 active site 937773003006 motif 2; other site 937773003007 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 937773003008 putative deacylase active site [active] 937773003009 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 937773003010 active site 937773003011 motif 3; other site 937773003012 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 937773003013 anticodon binding site; other site 937773003014 DNA polymerase III PolC; Validated; Region: polC; PRK00448 937773003015 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 937773003016 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 937773003017 generic binding surface II; other site 937773003018 generic binding surface I; other site 937773003019 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 937773003020 active site 937773003021 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 937773003022 active site 937773003023 catalytic site [active] 937773003024 substrate binding site [chemical binding]; other site 937773003025 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 937773003026 ribosome maturation protein RimP; Reviewed; Region: PRK00092 937773003027 Sm and related proteins; Region: Sm_like; cl00259 937773003028 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 937773003029 putative oligomer interface [polypeptide binding]; other site 937773003030 putative RNA binding site [nucleotide binding]; other site 937773003031 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 937773003032 NusA N-terminal domain; Region: NusA_N; pfam08529 937773003033 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 937773003034 RNA binding site [nucleotide binding]; other site 937773003035 homodimer interface [polypeptide binding]; other site 937773003036 NusA-like KH domain; Region: KH_5; pfam13184 937773003037 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 937773003038 G-X-X-G motif; other site 937773003039 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 937773003040 putative RNA binding cleft [nucleotide binding]; other site 937773003041 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 937773003042 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 937773003043 translation initiation factor IF-2; Region: IF-2; TIGR00487 937773003044 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 937773003045 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 937773003046 G1 box; other site 937773003047 putative GEF interaction site [polypeptide binding]; other site 937773003048 GTP/Mg2+ binding site [chemical binding]; other site 937773003049 Switch I region; other site 937773003050 G2 box; other site 937773003051 G3 box; other site 937773003052 Switch II region; other site 937773003053 G4 box; other site 937773003054 G5 box; other site 937773003055 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 937773003056 Translation-initiation factor 2; Region: IF-2; pfam11987 937773003057 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 937773003058 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 937773003059 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 937773003060 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 937773003061 RNA binding site [nucleotide binding]; other site 937773003062 active site 937773003063 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 937773003064 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 937773003065 active site 937773003066 Riboflavin kinase; Region: Flavokinase; smart00904 937773003067 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 937773003068 16S/18S rRNA binding site [nucleotide binding]; other site 937773003069 S13e-L30e interaction site [polypeptide binding]; other site 937773003070 25S rRNA binding site [nucleotide binding]; other site 937773003071 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 937773003072 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 937773003073 RNase E interface [polypeptide binding]; other site 937773003074 trimer interface [polypeptide binding]; other site 937773003075 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 937773003076 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 937773003077 RNase E interface [polypeptide binding]; other site 937773003078 trimer interface [polypeptide binding]; other site 937773003079 active site 937773003080 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 937773003081 putative nucleic acid binding region [nucleotide binding]; other site 937773003082 G-X-X-G motif; other site 937773003083 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 937773003084 RNA binding site [nucleotide binding]; other site 937773003085 domain interface; other site 937773003086 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 937773003087 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 937773003088 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 937773003089 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 937773003090 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 937773003091 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 937773003092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 937773003093 DNA-binding site [nucleotide binding]; DNA binding site 937773003094 UTRA domain; Region: UTRA; pfam07702 937773003095 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 937773003096 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 937773003097 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 937773003098 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 937773003099 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 937773003100 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 937773003101 classical (c) SDRs; Region: SDR_c; cd05233 937773003102 NAD(P) binding site [chemical binding]; other site 937773003103 active site 937773003104 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 937773003105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773003106 non-specific DNA binding site [nucleotide binding]; other site 937773003107 salt bridge; other site 937773003108 sequence-specific DNA binding site [nucleotide binding]; other site 937773003109 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 937773003110 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 937773003111 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 937773003112 putative MPT binding site; other site 937773003113 recombinase A; Provisional; Region: recA; PRK09354 937773003114 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 937773003115 hexamer interface [polypeptide binding]; other site 937773003116 Walker A motif; other site 937773003117 ATP binding site [chemical binding]; other site 937773003118 Walker B motif; other site 937773003119 phosphodiesterase; Provisional; Region: PRK12704 937773003120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 937773003121 Zn2+ binding site [ion binding]; other site 937773003122 Mg2+ binding site [ion binding]; other site 937773003123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 937773003124 dimerization interface [polypeptide binding]; other site 937773003125 putative DNA binding site [nucleotide binding]; other site 937773003126 putative Zn2+ binding site [ion binding]; other site 937773003127 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 937773003128 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 937773003129 metal-binding site [ion binding] 937773003130 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773003131 Soluble P-type ATPase [General function prediction only]; Region: COG4087 937773003132 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 937773003133 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 937773003134 putative active site [active] 937773003135 metal binding site [ion binding]; metal-binding site 937773003136 homodimer binding site [polypeptide binding]; other site 937773003137 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 937773003138 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 937773003139 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 937773003140 dimer interface [polypeptide binding]; other site 937773003141 PYR/PP interface [polypeptide binding]; other site 937773003142 TPP binding site [chemical binding]; other site 937773003143 substrate binding site [chemical binding]; other site 937773003144 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 937773003145 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 937773003146 TPP-binding site [chemical binding]; other site 937773003147 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 937773003148 Uncharacterized conserved protein [Function unknown]; Region: COG0011 937773003149 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 937773003150 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 937773003151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773003152 FeS/SAM binding site; other site 937773003153 TRAM domain; Region: TRAM; pfam01938 937773003154 Predicted membrane protein [Function unknown]; Region: COG4550 937773003155 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 937773003156 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 937773003157 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 937773003158 MutS domain I; Region: MutS_I; pfam01624 937773003159 MutS domain II; Region: MutS_II; pfam05188 937773003160 MutS domain III; Region: MutS_III; pfam05192 937773003161 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 937773003162 Walker A/P-loop; other site 937773003163 ATP binding site [chemical binding]; other site 937773003164 Q-loop/lid; other site 937773003165 ABC transporter signature motif; other site 937773003166 Walker B; other site 937773003167 D-loop; other site 937773003168 H-loop/switch region; other site 937773003169 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 937773003170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773003171 ATP binding site [chemical binding]; other site 937773003172 Mg2+ binding site [ion binding]; other site 937773003173 G-X-G motif; other site 937773003174 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 937773003175 ATP binding site [chemical binding]; other site 937773003176 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 937773003177 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 937773003178 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 937773003179 putative dimer interface [polypeptide binding]; other site 937773003180 catalytic triad [active] 937773003181 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 937773003182 amphipathic channel; other site 937773003183 Asn-Pro-Ala signature motifs; other site 937773003184 glycerol kinase; Provisional; Region: glpK; PRK00047 937773003185 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 937773003186 N- and C-terminal domain interface [polypeptide binding]; other site 937773003187 active site 937773003188 MgATP binding site [chemical binding]; other site 937773003189 catalytic site [active] 937773003190 metal binding site [ion binding]; metal-binding site 937773003191 glycerol binding site [chemical binding]; other site 937773003192 homotetramer interface [polypeptide binding]; other site 937773003193 homodimer interface [polypeptide binding]; other site 937773003194 FBP binding site [chemical binding]; other site 937773003195 protein IIAGlc interface [polypeptide binding]; other site 937773003196 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 937773003197 bacterial Hfq-like; Region: Hfq; cd01716 937773003198 hexamer interface [polypeptide binding]; other site 937773003199 Sm1 motif; other site 937773003200 RNA binding site [nucleotide binding]; other site 937773003201 Sm2 motif; other site 937773003202 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 937773003203 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 937773003204 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 937773003205 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 937773003206 PGAP1-like protein; Region: PGAP1; pfam07819 937773003207 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 937773003208 catalytic residues [active] 937773003209 dimer interface [polypeptide binding]; other site 937773003210 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 937773003211 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 937773003212 HflX GTPase family; Region: HflX; cd01878 937773003213 G1 box; other site 937773003214 GTP/Mg2+ binding site [chemical binding]; other site 937773003215 Switch I region; other site 937773003216 G2 box; other site 937773003217 G3 box; other site 937773003218 Switch II region; other site 937773003219 G4 box; other site 937773003220 G5 box; other site 937773003221 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 937773003222 Aluminium resistance protein; Region: Alum_res; pfam06838 937773003223 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 937773003224 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 937773003225 DNA binding residues [nucleotide binding] 937773003226 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 937773003227 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 937773003228 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 937773003229 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 937773003230 Int/Topo IB signature motif; other site 937773003231 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 937773003232 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 937773003233 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 937773003234 active site 937773003235 catalytic site [active] 937773003236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773003237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773003238 putative substrate translocation pore; other site 937773003239 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 937773003240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773003241 motif II; other site 937773003242 Staphylococcal nuclease homologues; Region: SNc; smart00318 937773003243 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 937773003244 Catalytic site; other site 937773003245 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 937773003246 Catalytic site; other site 937773003247 MarR family; Region: MarR_2; cl17246 937773003248 aspartate kinase; Reviewed; Region: PRK09034 937773003249 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 937773003250 putative catalytic residues [active] 937773003251 putative nucleotide binding site [chemical binding]; other site 937773003252 putative aspartate binding site [chemical binding]; other site 937773003253 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 937773003254 allosteric regulatory residue; other site 937773003255 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 937773003256 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 937773003257 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 937773003258 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 937773003259 threonine synthase; Reviewed; Region: PRK06721 937773003260 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 937773003261 homodimer interface [polypeptide binding]; other site 937773003262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773003263 catalytic residue [active] 937773003264 homoserine kinase; Provisional; Region: PRK01212 937773003265 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 937773003266 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 937773003267 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 937773003268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773003269 motif II; other site 937773003270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773003271 lysine transporter; Provisional; Region: PRK10836 937773003272 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 937773003273 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 937773003274 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 937773003275 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 937773003276 active site 937773003277 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 937773003278 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 937773003279 LexA repressor; Validated; Region: PRK00215 937773003280 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 937773003281 putative DNA binding site [nucleotide binding]; other site 937773003282 putative Zn2+ binding site [ion binding]; other site 937773003283 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 937773003284 Catalytic site [active] 937773003285 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 937773003286 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 937773003287 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 937773003288 TPP-binding site [chemical binding]; other site 937773003289 dimer interface [polypeptide binding]; other site 937773003290 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 937773003291 PYR/PP interface [polypeptide binding]; other site 937773003292 dimer interface [polypeptide binding]; other site 937773003293 TPP binding site [chemical binding]; other site 937773003294 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 937773003295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 937773003296 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 937773003297 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 937773003298 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 937773003299 active site 937773003300 metal binding site [ion binding]; metal-binding site 937773003301 DNA binding site [nucleotide binding] 937773003302 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 937773003303 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 937773003304 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 937773003305 Walker A/P-loop; other site 937773003306 ATP binding site [chemical binding]; other site 937773003307 Q-loop/lid; other site 937773003308 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 937773003309 ABC transporter signature motif; other site 937773003310 Walker B; other site 937773003311 D-loop; other site 937773003312 H-loop/switch region; other site 937773003313 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 937773003314 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 937773003315 BCCT family transporter; Region: BCCT; pfam02028 937773003316 aconitate hydratase; Validated; Region: PRK09277 937773003317 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 937773003318 substrate binding site [chemical binding]; other site 937773003319 ligand binding site [chemical binding]; other site 937773003320 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 937773003321 substrate binding site [chemical binding]; other site 937773003322 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 937773003323 active site 937773003324 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 937773003325 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 937773003326 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 937773003327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773003328 ATP binding site [chemical binding]; other site 937773003329 Mg2+ binding site [ion binding]; other site 937773003330 G-X-G motif; other site 937773003331 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 937773003332 anchoring element; other site 937773003333 dimer interface [polypeptide binding]; other site 937773003334 ATP binding site [chemical binding]; other site 937773003335 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 937773003336 active site 937773003337 putative metal-binding site [ion binding]; other site 937773003338 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 937773003339 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 937773003340 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 937773003341 CAP-like domain; other site 937773003342 active site 937773003343 primary dimer interface [polypeptide binding]; other site 937773003344 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773003345 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773003346 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 937773003347 amino acid carrier protein; Region: agcS; TIGR00835 937773003348 CAT RNA binding domain; Region: CAT_RBD; pfam03123 937773003349 transcriptional antiterminator BglG; Provisional; Region: PRK09772 937773003350 PRD domain; Region: PRD; pfam00874 937773003351 PRD domain; Region: PRD; pfam00874 937773003352 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 937773003353 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 937773003354 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773003355 active site turn [active] 937773003356 phosphorylation site [posttranslational modification] 937773003357 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 937773003358 HPr interaction site; other site 937773003359 glycerol kinase (GK) interaction site [polypeptide binding]; other site 937773003360 active site 937773003361 phosphorylation site [posttranslational modification] 937773003362 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 937773003363 Domain of unknown function DUF20; Region: UPF0118; pfam01594 937773003364 Predicted integral membrane protein [Function unknown]; Region: COG0392 937773003365 Uncharacterized conserved protein [Function unknown]; Region: COG2898 937773003366 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 937773003367 methionine sulfoxide reductase A; Provisional; Region: PRK14054 937773003368 Transcriptional regulator [Transcription]; Region: LytR; COG1316 937773003369 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 937773003370 active site 1 [active] 937773003371 dimer interface [polypeptide binding]; other site 937773003372 hexamer interface [polypeptide binding]; other site 937773003373 active site 2 [active] 937773003374 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 937773003375 DNA polymerase IV; Reviewed; Region: PRK03103 937773003376 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 937773003377 active site 937773003378 DNA binding site [nucleotide binding] 937773003379 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 937773003380 prephenate dehydrogenase; Validated; Region: PRK06545 937773003381 prephenate dehydrogenase; Validated; Region: PRK08507 937773003382 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 937773003383 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 937773003384 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 937773003385 putative oligomer interface [polypeptide binding]; other site 937773003386 putative active site [active] 937773003387 metal binding site [ion binding]; metal-binding site 937773003388 FemAB family; Region: FemAB; pfam02388 937773003389 FemAB family; Region: FemAB; pfam02388 937773003390 oligoendopeptidase F; Region: pepF; TIGR00181 937773003391 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 937773003392 active site 937773003393 Zn binding site [ion binding]; other site 937773003394 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 937773003395 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 937773003396 Cna protein B-type domain; Region: Cna_B; pfam05738 937773003397 Cna protein B-type domain; Region: Cna_B; pfam05738 937773003398 Cna protein B-type domain; Region: Cna_B; pfam05738 937773003399 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 937773003400 S1 domain; Region: S1_2; pfam13509 937773003401 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 937773003402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773003403 Walker A/P-loop; other site 937773003404 ATP binding site [chemical binding]; other site 937773003405 Q-loop/lid; other site 937773003406 ABC transporter signature motif; other site 937773003407 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773003408 Walker B; other site 937773003409 D-loop; other site 937773003410 H-loop/switch region; other site 937773003411 ABC transporter; Region: ABC_tran_2; pfam12848 937773003412 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773003413 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 937773003414 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 937773003415 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 937773003416 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 937773003417 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 937773003418 dimer interface [polypeptide binding]; other site 937773003419 active site 937773003420 catalytic residue [active] 937773003421 dihydrodipicolinate reductase; Provisional; Region: PRK00048 937773003422 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 937773003423 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 937773003424 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 937773003425 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 937773003426 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 937773003427 trimer interface [polypeptide binding]; other site 937773003428 active site 937773003429 substrate binding site [chemical binding]; other site 937773003430 CoA binding site [chemical binding]; other site 937773003431 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 937773003432 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 937773003433 metal binding site [ion binding]; metal-binding site 937773003434 dimer interface [polypeptide binding]; other site 937773003435 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 937773003436 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 937773003437 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773003438 catalytic residue [active] 937773003439 diaminopimelate decarboxylase; Region: lysA; TIGR01048 937773003440 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 937773003441 active site 937773003442 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773003443 substrate binding site [chemical binding]; other site 937773003444 catalytic residues [active] 937773003445 dimer interface [polypeptide binding]; other site 937773003446 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 937773003447 DNA-binding site [nucleotide binding]; DNA binding site 937773003448 RNA-binding motif; other site 937773003449 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 937773003450 Acylphosphatase; Region: Acylphosphatase; cl00551 937773003451 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 937773003452 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 937773003453 BCCT family transporter; Region: BCCT; cl00569 937773003454 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 937773003455 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 937773003456 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 937773003457 metal ion-dependent adhesion site (MIDAS); other site 937773003458 MoxR-like ATPases [General function prediction only]; Region: COG0714 937773003459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773003460 Walker A motif; other site 937773003461 ATP binding site [chemical binding]; other site 937773003462 Walker B motif; other site 937773003463 arginine finger; other site 937773003464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773003465 active site 937773003466 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 937773003467 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 937773003468 E3 interaction surface; other site 937773003469 lipoyl attachment site [posttranslational modification]; other site 937773003470 e3 binding domain; Region: E3_binding; pfam02817 937773003471 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 937773003472 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 937773003473 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 937773003474 TPP-binding site [chemical binding]; other site 937773003475 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 937773003476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 937773003477 HAMP domain; Region: HAMP; pfam00672 937773003478 dimerization interface [polypeptide binding]; other site 937773003479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773003480 dimer interface [polypeptide binding]; other site 937773003481 phosphorylation site [posttranslational modification] 937773003482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773003483 ATP binding site [chemical binding]; other site 937773003484 Mg2+ binding site [ion binding]; other site 937773003485 G-X-G motif; other site 937773003486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773003487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773003488 active site 937773003489 phosphorylation site [posttranslational modification] 937773003490 intermolecular recognition site; other site 937773003491 dimerization interface [polypeptide binding]; other site 937773003492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773003493 DNA binding site [nucleotide binding] 937773003494 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 937773003495 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 937773003496 active site 937773003497 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 937773003498 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 937773003499 active site 937773003500 homodimer interface [polypeptide binding]; other site 937773003501 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 937773003502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773003503 Coenzyme A binding pocket [chemical binding]; other site 937773003504 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 937773003505 C-terminal peptidase (prc); Region: prc; TIGR00225 937773003506 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 937773003507 protein binding site [polypeptide binding]; other site 937773003508 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 937773003509 Catalytic dyad [active] 937773003510 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 937773003511 hypothetical protein; Provisional; Region: PRK13672 937773003512 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 937773003513 HPr interaction site; other site 937773003514 glycerol kinase (GK) interaction site [polypeptide binding]; other site 937773003515 active site 937773003516 phosphorylation site [posttranslational modification] 937773003517 methionine sulfoxide reductase B; Provisional; Region: PRK00222 937773003518 SelR domain; Region: SelR; pfam01641 937773003519 methionine sulfoxide reductase A; Provisional; Region: PRK13014 937773003520 EDD domain protein, DegV family; Region: DegV; TIGR00762 937773003521 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 937773003522 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 937773003523 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 937773003524 folate binding site [chemical binding]; other site 937773003525 NADP+ binding site [chemical binding]; other site 937773003526 thymidylate synthase; Region: thym_sym; TIGR03284 937773003527 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 937773003528 dimerization interface [polypeptide binding]; other site 937773003529 active site 937773003530 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 937773003531 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 937773003532 Virulence factor; Region: Virulence_fact; pfam13769 937773003533 HEAT repeats; Region: HEAT_2; pfam13646 937773003534 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 937773003535 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 937773003536 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 937773003537 RNA/DNA hybrid binding site [nucleotide binding]; other site 937773003538 active site 937773003539 5'-3' exonuclease; Region: 53EXOc; smart00475 937773003540 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 937773003541 active site 937773003542 metal binding site 1 [ion binding]; metal-binding site 937773003543 putative 5' ssDNA interaction site; other site 937773003544 metal binding site 3; metal-binding site 937773003545 metal binding site 2 [ion binding]; metal-binding site 937773003546 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 937773003547 putative DNA binding site [nucleotide binding]; other site 937773003548 putative metal binding site [ion binding]; other site 937773003549 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 937773003550 Dynamin family; Region: Dynamin_N; pfam00350 937773003551 G1 box; other site 937773003552 GTP/Mg2+ binding site [chemical binding]; other site 937773003553 G2 box; other site 937773003554 Switch I region; other site 937773003555 G3 box; other site 937773003556 Switch II region; other site 937773003557 G4 box; other site 937773003558 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 937773003559 GTP/Mg2+ binding site [chemical binding]; other site 937773003560 G5 box; other site 937773003561 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 937773003562 Dynamin family; Region: Dynamin_N; pfam00350 937773003563 G1 box; other site 937773003564 G1 box; other site 937773003565 GTP/Mg2+ binding site [chemical binding]; other site 937773003566 G2 box; other site 937773003567 Switch I region; other site 937773003568 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 937773003569 G3 box; other site 937773003570 Switch II region; other site 937773003571 GTP/Mg2+ binding site [chemical binding]; other site 937773003572 G4 box; other site 937773003573 G5 box; other site 937773003574 Predicted permeases [General function prediction only]; Region: RarD; COG2962 937773003575 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 937773003576 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 937773003577 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 937773003578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 937773003579 cell division protein GpsB; Provisional; Region: PRK14127 937773003580 DivIVA domain; Region: DivI1A_domain; TIGR03544 937773003581 hypothetical protein; Provisional; Region: PRK13660 937773003582 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 937773003583 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 937773003584 Transglycosylase; Region: Transgly; pfam00912 937773003585 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 937773003586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 937773003587 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 937773003588 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 937773003589 minor groove reading motif; other site 937773003590 helix-hairpin-helix signature motif; other site 937773003591 substrate binding pocket [chemical binding]; other site 937773003592 active site 937773003593 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 937773003594 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 937773003595 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 937773003596 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 937773003597 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 937773003598 putative dimer interface [polypeptide binding]; other site 937773003599 putative anticodon binding site; other site 937773003600 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 937773003601 homodimer interface [polypeptide binding]; other site 937773003602 motif 1; other site 937773003603 motif 2; other site 937773003604 active site 937773003605 motif 3; other site 937773003606 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 937773003607 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 937773003608 active site 937773003609 catalytic site [active] 937773003610 substrate binding site [chemical binding]; other site 937773003611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 937773003612 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 937773003613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773003614 DNA-binding site [nucleotide binding]; DNA binding site 937773003615 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 937773003616 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 937773003617 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 937773003618 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 937773003619 active site 937773003620 NTP binding site [chemical binding]; other site 937773003621 metal binding triad [ion binding]; metal-binding site 937773003622 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 937773003623 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 937773003624 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 937773003625 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 937773003626 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 937773003627 homodimer interface [polypeptide binding]; other site 937773003628 metal binding site [ion binding]; metal-binding site 937773003629 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 937773003630 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 937773003631 Uncharacterized conserved protein [Function unknown]; Region: COG5582 937773003632 UPF0302 domain; Region: UPF0302; pfam08864 937773003633 TPR repeat; Region: TPR_11; pfam13414 937773003634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773003635 binding surface 937773003636 TPR motif; other site 937773003637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773003638 TPR motif; other site 937773003639 binding surface 937773003640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 937773003641 binding surface 937773003642 TPR motif; other site 937773003643 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 937773003644 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 937773003645 hinge; other site 937773003646 active site 937773003647 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 937773003648 active site 937773003649 dimer interface [polypeptide binding]; other site 937773003650 metal binding site [ion binding]; metal-binding site 937773003651 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 937773003652 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 937773003653 Tetramer interface [polypeptide binding]; other site 937773003654 active site 937773003655 FMN-binding site [chemical binding]; other site 937773003656 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 937773003657 active site 937773003658 multimer interface [polypeptide binding]; other site 937773003659 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 937773003660 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 937773003661 substrate binding pocket [chemical binding]; other site 937773003662 chain length determination region; other site 937773003663 substrate-Mg2+ binding site; other site 937773003664 catalytic residues [active] 937773003665 aspartate-rich region 1; other site 937773003666 active site lid residues [active] 937773003667 aspartate-rich region 2; other site 937773003668 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 937773003669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773003670 S-adenosylmethionine binding site [chemical binding]; other site 937773003671 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 937773003672 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 937773003673 IHF dimer interface [polypeptide binding]; other site 937773003674 IHF - DNA interface [nucleotide binding]; other site 937773003675 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 937773003676 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 937773003677 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 937773003678 GTP-binding protein Der; Reviewed; Region: PRK00093 937773003679 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 937773003680 G1 box; other site 937773003681 GTP/Mg2+ binding site [chemical binding]; other site 937773003682 Switch I region; other site 937773003683 G2 box; other site 937773003684 Switch II region; other site 937773003685 G3 box; other site 937773003686 G4 box; other site 937773003687 G5 box; other site 937773003688 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 937773003689 G1 box; other site 937773003690 GTP/Mg2+ binding site [chemical binding]; other site 937773003691 Switch I region; other site 937773003692 G2 box; other site 937773003693 G3 box; other site 937773003694 Switch II region; other site 937773003695 G4 box; other site 937773003696 G5 box; other site 937773003697 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 937773003698 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 937773003699 RNA binding site [nucleotide binding]; other site 937773003700 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 937773003701 RNA binding site [nucleotide binding]; other site 937773003702 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 937773003703 RNA binding site [nucleotide binding]; other site 937773003704 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 937773003705 RNA binding site [nucleotide binding]; other site 937773003706 cytidylate kinase; Provisional; Region: cmk; PRK00023 937773003707 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 937773003708 CMP-binding site; other site 937773003709 The sites determining sugar specificity; other site 937773003710 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 937773003711 active site 937773003712 homotetramer interface [polypeptide binding]; other site 937773003713 homodimer interface [polypeptide binding]; other site 937773003714 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 937773003715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 937773003716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773003717 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 937773003718 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 937773003719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773003720 ATP binding site [chemical binding]; other site 937773003721 putative Mg++ binding site [ion binding]; other site 937773003722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773003723 nucleotide binding region [chemical binding]; other site 937773003724 ATP-binding site [chemical binding]; other site 937773003725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 937773003726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 937773003727 DNA binding residues [nucleotide binding] 937773003728 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 937773003729 Predicted membrane protein [Function unknown]; Region: COG3601 937773003730 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 937773003731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 937773003732 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 937773003733 dimerization interface [polypeptide binding]; other site 937773003734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773003735 dimer interface [polypeptide binding]; other site 937773003736 phosphorylation site [posttranslational modification] 937773003737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773003738 ATP binding site [chemical binding]; other site 937773003739 Mg2+ binding site [ion binding]; other site 937773003740 G-X-G motif; other site 937773003741 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773003742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773003743 active site 937773003744 phosphorylation site [posttranslational modification] 937773003745 intermolecular recognition site; other site 937773003746 dimerization interface [polypeptide binding]; other site 937773003747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773003748 DNA binding site [nucleotide binding] 937773003749 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 937773003750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773003751 RNA binding surface [nucleotide binding]; other site 937773003752 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 937773003753 active site 937773003754 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 937773003755 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 937773003756 Domain of unknown function (DUF309); Region: DUF309; cl00667 937773003757 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 937773003758 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 937773003759 active site 937773003760 Int/Topo IB signature motif; other site 937773003761 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 937773003762 metal binding site 2 [ion binding]; metal-binding site 937773003763 putative DNA binding helix; other site 937773003764 metal binding site 1 [ion binding]; metal-binding site 937773003765 dimer interface [polypeptide binding]; other site 937773003766 structural Zn2+ binding site [ion binding]; other site 937773003767 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 937773003768 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 937773003769 dimer interface [polypeptide binding]; other site 937773003770 ADP-ribose binding site [chemical binding]; other site 937773003771 active site 937773003772 nudix motif; other site 937773003773 metal binding site [ion binding]; metal-binding site 937773003774 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 937773003775 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 937773003776 active site 937773003777 catalytic tetrad [active] 937773003778 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 937773003779 classical (c) SDRs; Region: SDR_c; cd05233 937773003780 NAD(P) binding site [chemical binding]; other site 937773003781 active site 937773003782 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 937773003783 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 937773003784 ribonuclease Z; Region: RNase_Z; TIGR02651 937773003785 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 937773003786 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 937773003787 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 937773003788 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 937773003789 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 937773003790 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773003791 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 937773003792 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 937773003793 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 937773003794 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 937773003795 peptidase T-like protein; Region: PepT-like; TIGR01883 937773003796 metal binding site [ion binding]; metal-binding site 937773003797 putative dimer interface [polypeptide binding]; other site 937773003798 Predicted membrane protein [Function unknown]; Region: COG4129 937773003799 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 937773003800 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 937773003801 Disulphide isomerase; Region: Disulph_isomer; pfam06491 937773003802 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 937773003803 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 937773003804 E3 interaction surface; other site 937773003805 lipoyl attachment site [posttranslational modification]; other site 937773003806 e3 binding domain; Region: E3_binding; pfam02817 937773003807 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 937773003808 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 937773003809 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 937773003810 alpha subunit interface [polypeptide binding]; other site 937773003811 TPP binding site [chemical binding]; other site 937773003812 heterodimer interface [polypeptide binding]; other site 937773003813 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 937773003814 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 937773003815 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 937773003816 tetramer interface [polypeptide binding]; other site 937773003817 TPP-binding site [chemical binding]; other site 937773003818 heterodimer interface [polypeptide binding]; other site 937773003819 phosphorylation loop region [posttranslational modification] 937773003820 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 937773003821 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 937773003822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773003823 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 937773003824 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 937773003825 nucleotide binding site [chemical binding]; other site 937773003826 Acetokinase family; Region: Acetate_kinase; cl17229 937773003827 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 937773003828 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 937773003829 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 937773003830 Walker A/P-loop; other site 937773003831 ATP binding site [chemical binding]; other site 937773003832 Q-loop/lid; other site 937773003833 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 937773003834 ABC transporter signature motif; other site 937773003835 Walker B; other site 937773003836 D-loop; other site 937773003837 H-loop/switch region; other site 937773003838 arginine repressor; Provisional; Region: PRK04280 937773003839 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 937773003840 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 937773003841 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 937773003842 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 937773003843 TPP-binding site; other site 937773003844 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 937773003845 PYR/PP interface [polypeptide binding]; other site 937773003846 dimer interface [polypeptide binding]; other site 937773003847 TPP binding site [chemical binding]; other site 937773003848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 937773003849 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 937773003850 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 937773003851 substrate binding pocket [chemical binding]; other site 937773003852 chain length determination region; other site 937773003853 substrate-Mg2+ binding site; other site 937773003854 catalytic residues [active] 937773003855 aspartate-rich region 1; other site 937773003856 active site lid residues [active] 937773003857 aspartate-rich region 2; other site 937773003858 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 937773003859 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 937773003860 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 937773003861 generic binding surface II; other site 937773003862 generic binding surface I; other site 937773003863 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 937773003864 putative RNA binding site [nucleotide binding]; other site 937773003865 Asp23 family; Region: Asp23; pfam03780 937773003866 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 937773003867 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773003868 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 937773003869 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 937773003870 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 937773003871 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 937773003872 carboxyltransferase (CT) interaction site; other site 937773003873 biotinylation site [posttranslational modification]; other site 937773003874 elongation factor P; Validated; Region: PRK00529 937773003875 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 937773003876 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 937773003877 RNA binding site [nucleotide binding]; other site 937773003878 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 937773003879 RNA binding site [nucleotide binding]; other site 937773003880 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 937773003881 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 937773003882 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 937773003883 active site 937773003884 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 937773003885 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 937773003886 active site residue [active] 937773003887 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 937773003888 tetramer interface [polypeptide binding]; other site 937773003889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773003890 catalytic residue [active] 937773003891 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 937773003892 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 937773003893 tetramer interface [polypeptide binding]; other site 937773003894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773003895 catalytic residue [active] 937773003896 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 937773003897 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 937773003898 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 937773003899 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 937773003900 ADP binding site [chemical binding]; other site 937773003901 magnesium binding site [ion binding]; other site 937773003902 putative shikimate binding site; other site 937773003903 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 937773003904 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 937773003905 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 937773003906 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 937773003907 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 937773003908 ATP binding site [chemical binding]; other site 937773003909 Walker B motif; other site 937773003910 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 937773003911 ParB-like nuclease domain; Region: ParBc; pfam02195 937773003912 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 937773003913 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 937773003914 Active Sites [active] 937773003915 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 937773003916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 937773003917 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 937773003918 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 937773003919 amidase catalytic site [active] 937773003920 Zn binding residues [ion binding]; other site 937773003921 substrate binding site [chemical binding]; other site 937773003922 Holin family; Region: Phage_holin_4; pfam05105 937773003923 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 937773003924 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 937773003925 active site 937773003926 catalytic triad [active] 937773003927 oxyanion hole [active] 937773003928 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 937773003929 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 937773003930 active site 937773003931 oxyanion hole [active] 937773003932 catalytic triad [active] 937773003933 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 937773003934 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 937773003935 Phage tail protein; Region: Sipho_tail; pfam05709 937773003936 Phage-related minor tail protein [Function unknown]; Region: COG5280 937773003937 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 937773003938 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 937773003939 Peptidase family M23; Region: Peptidase_M23; pfam01551 937773003940 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 937773003941 N-acetyl-D-glucosamine binding site [chemical binding]; other site 937773003942 catalytic residue [active] 937773003943 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 937773003944 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 937773003945 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 937773003946 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 937773003947 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 937773003948 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 937773003949 oligomer interface [polypeptide binding]; other site 937773003950 active site residues [active] 937773003951 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 937773003952 Phage-related protein [Function unknown]; Region: COG4695; cl01923 937773003953 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 937773003954 Phage terminase, small subunit; Region: Terminase_4; cl01525 937773003955 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 937773003956 active site 937773003957 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 937773003958 putative metal binding site [ion binding]; other site 937773003959 YopX protein; Region: YopX; pfam09643 937773003960 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 937773003961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773003962 Walker A motif; other site 937773003963 ATP binding site [chemical binding]; other site 937773003964 Walker B motif; other site 937773003965 arginine finger; other site 937773003966 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 937773003967 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 937773003968 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 937773003969 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 937773003970 dimer interface [polypeptide binding]; other site 937773003971 ssDNA binding site [nucleotide binding]; other site 937773003972 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773003973 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 937773003974 RecT family; Region: RecT; pfam03837 937773003975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773003976 non-specific DNA binding site [nucleotide binding]; other site 937773003977 salt bridge; other site 937773003978 sequence-specific DNA binding site [nucleotide binding]; other site 937773003979 AAA domain; Region: AAA_23; pfam13476 937773003980 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 937773003981 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 937773003982 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 937773003983 DNA-binding interface [nucleotide binding]; DNA binding site 937773003984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 937773003985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773003986 non-specific DNA binding site [nucleotide binding]; other site 937773003987 salt bridge; other site 937773003988 sequence-specific DNA binding site [nucleotide binding]; other site 937773003989 Domain of unknown function (DUF955); Region: DUF955; pfam06114 937773003990 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 937773003991 active site 937773003992 DNA binding site [nucleotide binding] 937773003993 Int/Topo IB signature motif; other site 937773003994 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 937773003995 Walker A motif; other site 937773003996 ATP binding site [chemical binding]; other site 937773003997 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 937773003998 Uncharacterized conserved protein [Function unknown]; Region: COG0011 937773003999 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 937773004000 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 937773004001 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 937773004002 Rhomboid family; Region: Rhomboid; pfam01694 937773004003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773004004 binding surface 937773004005 TPR motif; other site 937773004006 TPR repeat; Region: TPR_11; pfam13414 937773004007 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 937773004008 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 937773004009 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 937773004010 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 937773004011 PhoU domain; Region: PhoU; pfam01895 937773004012 PhoU domain; Region: PhoU; pfam01895 937773004013 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 937773004014 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 937773004015 Walker A/P-loop; other site 937773004016 ATP binding site [chemical binding]; other site 937773004017 Q-loop/lid; other site 937773004018 ABC transporter signature motif; other site 937773004019 Walker B; other site 937773004020 D-loop; other site 937773004021 H-loop/switch region; other site 937773004022 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 937773004023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773004024 dimer interface [polypeptide binding]; other site 937773004025 conserved gate region; other site 937773004026 putative PBP binding loops; other site 937773004027 ABC-ATPase subunit interface; other site 937773004028 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 937773004029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773004030 dimer interface [polypeptide binding]; other site 937773004031 conserved gate region; other site 937773004032 putative PBP binding loops; other site 937773004033 ABC-ATPase subunit interface; other site 937773004034 PBP superfamily domain; Region: PBP_like_2; cl17296 937773004035 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 937773004036 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 937773004037 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 937773004038 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 937773004039 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 937773004040 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 937773004041 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 937773004042 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 937773004043 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 937773004044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 937773004045 Transposase; Region: DDE_Tnp_ISL3; pfam01610 937773004046 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 937773004047 metal binding site 2 [ion binding]; metal-binding site 937773004048 putative DNA binding helix; other site 937773004049 metal binding site 1 [ion binding]; metal-binding site 937773004050 dimer interface [polypeptide binding]; other site 937773004051 structural Zn2+ binding site [ion binding]; other site 937773004052 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 937773004053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773004054 ABC-ATPase subunit interface; other site 937773004055 dimer interface [polypeptide binding]; other site 937773004056 putative PBP binding regions; other site 937773004057 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 937773004058 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 937773004059 endonuclease IV; Provisional; Region: PRK01060 937773004060 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 937773004061 AP (apurinic/apyrimidinic) site pocket; other site 937773004062 DNA interaction; other site 937773004063 Metal-binding active site; metal-binding site 937773004064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 937773004065 DEAD-like helicases superfamily; Region: DEXDc; smart00487 937773004066 ATP binding site [chemical binding]; other site 937773004067 putative Mg++ binding site [ion binding]; other site 937773004068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773004069 nucleotide binding region [chemical binding]; other site 937773004070 ATP-binding site [chemical binding]; other site 937773004071 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 937773004072 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 937773004073 Uncharacterized conserved protein [Function unknown]; Region: COG0327 937773004074 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 937773004075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 937773004076 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 937773004077 Uncharacterized conserved protein [Function unknown]; Region: COG0327 937773004078 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 937773004079 Family of unknown function (DUF633); Region: DUF633; pfam04816 937773004080 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 937773004081 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 937773004082 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 937773004083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 937773004084 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 937773004085 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 937773004086 DNA binding residues [nucleotide binding] 937773004087 DNA primase, catalytic core; Region: dnaG; TIGR01391 937773004088 CHC2 zinc finger; Region: zf-CHC2; pfam01807 937773004089 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 937773004090 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 937773004091 active site 937773004092 metal binding site [ion binding]; metal-binding site 937773004093 interdomain interaction site; other site 937773004094 PEP synthetase regulatory protein; Provisional; Region: PRK05339 937773004095 FOG: CBS domain [General function prediction only]; Region: COG0517 937773004096 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 937773004097 glycyl-tRNA synthetase; Provisional; Region: PRK04173 937773004098 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 937773004099 motif 1; other site 937773004100 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 937773004101 active site 937773004102 motif 2; other site 937773004103 motif 3; other site 937773004104 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 937773004105 anticodon binding site; other site 937773004106 Recombination protein O N terminal; Region: RecO_N; pfam11967 937773004107 DNA repair protein RecO; Region: reco; TIGR00613 937773004108 Recombination protein O C terminal; Region: RecO_C; pfam02565 937773004109 GTPase Era; Reviewed; Region: era; PRK00089 937773004110 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 937773004111 G1 box; other site 937773004112 GTP/Mg2+ binding site [chemical binding]; other site 937773004113 Switch I region; other site 937773004114 G2 box; other site 937773004115 Switch II region; other site 937773004116 G3 box; other site 937773004117 G4 box; other site 937773004118 G5 box; other site 937773004119 KH domain; Region: KH_2; pfam07650 937773004120 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 937773004121 active site 937773004122 catalytic motif [active] 937773004123 Zn binding site [ion binding]; other site 937773004124 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 937773004125 metal-binding heat shock protein; Provisional; Region: PRK00016 937773004126 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 937773004127 PhoH-like protein; Region: PhoH; pfam02562 937773004128 peptide chain release factor 1; Region: prfA; TIGR00019 937773004129 hypothetical protein; Provisional; Region: PRK13665 937773004130 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 937773004131 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 937773004132 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 937773004133 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 937773004134 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773004135 FeS/SAM binding site; other site 937773004136 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 937773004137 RNA methyltransferase, RsmE family; Region: TIGR00046 937773004138 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 937773004139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004140 S-adenosylmethionine binding site [chemical binding]; other site 937773004141 chaperone protein DnaJ; Provisional; Region: PRK14280 937773004142 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 937773004143 HSP70 interaction site [polypeptide binding]; other site 937773004144 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 937773004145 substrate binding site [polypeptide binding]; other site 937773004146 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 937773004147 Zn binding sites [ion binding]; other site 937773004148 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 937773004149 dimer interface [polypeptide binding]; other site 937773004150 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 937773004151 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 937773004152 nucleotide binding site [chemical binding]; other site 937773004153 NEF interaction site [polypeptide binding]; other site 937773004154 SBD interface [polypeptide binding]; other site 937773004155 GrpE; Region: GrpE; pfam01025 937773004156 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 937773004157 dimer interface [polypeptide binding]; other site 937773004158 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 937773004159 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 937773004160 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 937773004161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773004162 FeS/SAM binding site; other site 937773004163 HemN C-terminal domain; Region: HemN_C; pfam06969 937773004164 GTP-binding protein LepA; Provisional; Region: PRK05433 937773004165 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 937773004166 G1 box; other site 937773004167 putative GEF interaction site [polypeptide binding]; other site 937773004168 GTP/Mg2+ binding site [chemical binding]; other site 937773004169 Switch I region; other site 937773004170 G2 box; other site 937773004171 G3 box; other site 937773004172 Switch II region; other site 937773004173 G4 box; other site 937773004174 G5 box; other site 937773004175 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 937773004176 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 937773004177 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 937773004178 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 937773004179 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 937773004180 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 937773004181 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 937773004182 Competence protein; Region: Competence; pfam03772 937773004183 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 937773004184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 937773004185 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 937773004186 catalytic motif [active] 937773004187 Zn binding site [ion binding]; other site 937773004188 SLBB domain; Region: SLBB; pfam10531 937773004189 comEA protein; Region: comE; TIGR01259 937773004190 Helix-hairpin-helix motif; Region: HHH; pfam00633 937773004191 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 937773004192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004193 S-adenosylmethionine binding site [chemical binding]; other site 937773004194 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 937773004195 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 937773004196 Zn2+ binding site [ion binding]; other site 937773004197 Mg2+ binding site [ion binding]; other site 937773004198 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 937773004199 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 937773004200 active site 937773004201 (T/H)XGH motif; other site 937773004202 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 937773004203 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 937773004204 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 937773004205 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 937773004206 shikimate binding site; other site 937773004207 NAD(P) binding site [chemical binding]; other site 937773004208 GTPase YqeH; Provisional; Region: PRK13796 937773004209 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 937773004210 GTP/Mg2+ binding site [chemical binding]; other site 937773004211 G4 box; other site 937773004212 G5 box; other site 937773004213 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 937773004214 G1 box; other site 937773004215 Switch I region; other site 937773004216 G2 box; other site 937773004217 G3 box; other site 937773004218 Switch II region; other site 937773004219 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 937773004220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773004221 active site 937773004222 motif I; other site 937773004223 motif II; other site 937773004224 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 937773004225 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 937773004226 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 937773004227 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 937773004228 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 937773004229 putative active site [active] 937773004230 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 937773004231 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 937773004232 ATP-grasp domain; Region: ATP-grasp_4; cl17255 937773004233 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 937773004234 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 937773004235 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 937773004236 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 937773004237 carboxyltransferase (CT) interaction site; other site 937773004238 biotinylation site [posttranslational modification]; other site 937773004239 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 937773004240 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 937773004241 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 937773004242 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 937773004243 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 937773004244 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 937773004245 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 937773004246 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 937773004247 Sugar specificity; other site 937773004248 Pyrimidine base specificity; other site 937773004249 ATP-binding site [chemical binding]; other site 937773004250 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 937773004251 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 937773004252 Peptidase family U32; Region: Peptidase_U32; pfam01136 937773004253 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 937773004254 Peptidase family U32; Region: Peptidase_U32; pfam01136 937773004255 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 937773004256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004257 S-adenosylmethionine binding site [chemical binding]; other site 937773004258 hypothetical protein; Provisional; Region: PRK13678 937773004259 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 937773004260 hypothetical protein; Provisional; Region: PRK05473 937773004261 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 937773004262 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 937773004263 motif 1; other site 937773004264 active site 937773004265 motif 2; other site 937773004266 motif 3; other site 937773004267 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 937773004268 DHHA1 domain; Region: DHHA1; pfam02272 937773004269 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 937773004270 AAA domain; Region: AAA_30; pfam13604 937773004271 Family description; Region: UvrD_C_2; pfam13538 937773004272 TPR repeat; Region: TPR_11; pfam13414 937773004273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 937773004274 binding surface 937773004275 TPR motif; other site 937773004276 TPR repeat; Region: TPR_11; pfam13414 937773004277 TPR repeat; Region: TPR_11; pfam13414 937773004278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 937773004279 TPR motif; other site 937773004280 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 937773004281 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 937773004282 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 937773004283 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 937773004284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773004285 catalytic residue [active] 937773004286 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 937773004287 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 937773004288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 937773004289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 937773004290 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 937773004291 active site 937773004292 catalytic tetrad [active] 937773004293 Predicted transcriptional regulator [Transcription]; Region: COG1959 937773004294 Transcriptional regulator; Region: Rrf2; pfam02082 937773004295 recombination factor protein RarA; Reviewed; Region: PRK13342 937773004296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773004297 Walker A motif; other site 937773004298 ATP binding site [chemical binding]; other site 937773004299 Walker B motif; other site 937773004300 arginine finger; other site 937773004301 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 937773004302 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 937773004303 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 937773004304 putative ATP binding site [chemical binding]; other site 937773004305 putative substrate interface [chemical binding]; other site 937773004306 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 937773004307 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 937773004308 dimer interface [polypeptide binding]; other site 937773004309 anticodon binding site; other site 937773004310 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 937773004311 homodimer interface [polypeptide binding]; other site 937773004312 motif 1; other site 937773004313 active site 937773004314 motif 2; other site 937773004315 GAD domain; Region: GAD; pfam02938 937773004316 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 937773004317 motif 3; other site 937773004318 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 937773004319 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 937773004320 dimer interface [polypeptide binding]; other site 937773004321 motif 1; other site 937773004322 active site 937773004323 motif 2; other site 937773004324 motif 3; other site 937773004325 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 937773004326 anticodon binding site; other site 937773004327 Bacterial SH3 domain homologues; Region: SH3b; smart00287 937773004328 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 937773004329 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 937773004330 active site 937773004331 metal binding site [ion binding]; metal-binding site 937773004332 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 937773004333 putative active site [active] 937773004334 dimerization interface [polypeptide binding]; other site 937773004335 putative tRNAtyr binding site [nucleotide binding]; other site 937773004336 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 937773004337 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 937773004338 Zn2+ binding site [ion binding]; other site 937773004339 Mg2+ binding site [ion binding]; other site 937773004340 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 937773004341 synthetase active site [active] 937773004342 NTP binding site [chemical binding]; other site 937773004343 metal binding site [ion binding]; metal-binding site 937773004344 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 937773004345 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 937773004346 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773004347 active site 937773004348 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 937773004349 DHH family; Region: DHH; pfam01368 937773004350 DHHA1 domain; Region: DHHA1; pfam02272 937773004351 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 937773004352 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 937773004353 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 937773004354 Protein export membrane protein; Region: SecD_SecF; cl14618 937773004355 Protein export membrane protein; Region: SecD_SecF; pfam02355 937773004356 Preprotein translocase subunit; Region: YajC; pfam02699 937773004357 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 937773004358 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 937773004359 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 937773004360 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 937773004361 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 937773004362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773004363 Walker A motif; other site 937773004364 ATP binding site [chemical binding]; other site 937773004365 Walker B motif; other site 937773004366 arginine finger; other site 937773004367 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 937773004368 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 937773004369 RuvA N terminal domain; Region: RuvA_N; pfam01330 937773004370 hypothetical protein; Provisional; Region: PRK04435 937773004371 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 937773004372 GTPase CgtA; Reviewed; Region: obgE; PRK12297 937773004373 GTP1/OBG; Region: GTP1_OBG; pfam01018 937773004374 Obg GTPase; Region: Obg; cd01898 937773004375 G1 box; other site 937773004376 GTP/Mg2+ binding site [chemical binding]; other site 937773004377 Switch I region; other site 937773004378 G2 box; other site 937773004379 G3 box; other site 937773004380 Switch II region; other site 937773004381 G4 box; other site 937773004382 G5 box; other site 937773004383 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 937773004384 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 937773004385 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 937773004386 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 937773004387 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 937773004388 rod shape-determining protein MreD; Region: MreD; cl01087 937773004389 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 937773004390 rod shape-determining protein MreC; Region: MreC; pfam04085 937773004391 hypothetical protein; Reviewed; Region: PRK00024 937773004392 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 937773004393 MPN+ (JAMM) motif; other site 937773004394 Zinc-binding site [ion binding]; other site 937773004395 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 937773004396 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 937773004397 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 937773004398 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773004399 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773004400 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 937773004401 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 937773004402 active site 937773004403 HIGH motif; other site 937773004404 nucleotide binding site [chemical binding]; other site 937773004405 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 937773004406 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 937773004407 active site 937773004408 KMSKS motif; other site 937773004409 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 937773004410 tRNA binding surface [nucleotide binding]; other site 937773004411 anticodon binding site; other site 937773004412 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 937773004413 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 937773004414 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 937773004415 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 937773004416 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 937773004417 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 937773004418 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 937773004419 inhibitor-cofactor binding pocket; inhibition site 937773004420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773004421 catalytic residue [active] 937773004422 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 937773004423 dimer interface [polypeptide binding]; other site 937773004424 active site 937773004425 Schiff base residues; other site 937773004426 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 937773004427 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 937773004428 active site 937773004429 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 937773004430 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 937773004431 domain interfaces; other site 937773004432 active site 937773004433 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 937773004434 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 937773004435 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 937773004436 tRNA; other site 937773004437 putative tRNA binding site [nucleotide binding]; other site 937773004438 putative NADP binding site [chemical binding]; other site 937773004439 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 937773004440 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 937773004441 G1 box; other site 937773004442 GTP/Mg2+ binding site [chemical binding]; other site 937773004443 Switch I region; other site 937773004444 G2 box; other site 937773004445 G3 box; other site 937773004446 Switch II region; other site 937773004447 G4 box; other site 937773004448 G5 box; other site 937773004449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 937773004450 Transposase; Region: DDE_Tnp_ISL3; pfam01610 937773004451 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 937773004452 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 937773004453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773004454 Walker A motif; other site 937773004455 ATP binding site [chemical binding]; other site 937773004456 Walker B motif; other site 937773004457 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 937773004458 trigger factor; Provisional; Region: tig; PRK01490 937773004459 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 937773004460 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 937773004461 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 937773004462 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 937773004463 23S rRNA binding site [nucleotide binding]; other site 937773004464 L21 binding site [polypeptide binding]; other site 937773004465 L13 binding site [polypeptide binding]; other site 937773004466 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 937773004467 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 937773004468 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 937773004469 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 937773004470 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 937773004471 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 937773004472 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 937773004473 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 937773004474 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 937773004475 active site 937773004476 dimer interface [polypeptide binding]; other site 937773004477 motif 1; other site 937773004478 motif 2; other site 937773004479 motif 3; other site 937773004480 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 937773004481 anticodon binding site; other site 937773004482 primosomal protein DnaI; Reviewed; Region: PRK08939 937773004483 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 937773004484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773004485 Walker A motif; other site 937773004486 ATP binding site [chemical binding]; other site 937773004487 Walker B motif; other site 937773004488 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 937773004489 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 937773004490 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 937773004491 ATP cone domain; Region: ATP-cone; pfam03477 937773004492 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 937773004493 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 937773004494 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 937773004495 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 937773004496 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 937773004497 CoA-binding site [chemical binding]; other site 937773004498 ATP-binding [chemical binding]; other site 937773004499 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 937773004500 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 937773004501 DNA binding site [nucleotide binding] 937773004502 catalytic residue [active] 937773004503 H2TH interface [polypeptide binding]; other site 937773004504 putative catalytic residues [active] 937773004505 turnover-facilitating residue; other site 937773004506 intercalation triad [nucleotide binding]; other site 937773004507 8OG recognition residue [nucleotide binding]; other site 937773004508 putative reading head residues; other site 937773004509 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 937773004510 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 937773004511 DNA polymerase I; Provisional; Region: PRK05755 937773004512 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 937773004513 active site 937773004514 metal binding site 1 [ion binding]; metal-binding site 937773004515 putative 5' ssDNA interaction site; other site 937773004516 metal binding site 3; metal-binding site 937773004517 metal binding site 2 [ion binding]; metal-binding site 937773004518 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 937773004519 putative DNA binding site [nucleotide binding]; other site 937773004520 putative metal binding site [ion binding]; other site 937773004521 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 937773004522 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 937773004523 active site 937773004524 DNA binding site [nucleotide binding] 937773004525 catalytic site [active] 937773004526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 937773004527 dimerization interface [polypeptide binding]; other site 937773004528 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 937773004529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 937773004530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773004531 dimer interface [polypeptide binding]; other site 937773004532 phosphorylation site [posttranslational modification] 937773004533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773004534 ATP binding site [chemical binding]; other site 937773004535 Mg2+ binding site [ion binding]; other site 937773004536 G-X-G motif; other site 937773004537 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773004538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773004539 active site 937773004540 phosphorylation site [posttranslational modification] 937773004541 intermolecular recognition site; other site 937773004542 dimerization interface [polypeptide binding]; other site 937773004543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773004544 DNA binding site [nucleotide binding] 937773004545 isocitrate dehydrogenase; Reviewed; Region: PRK07006 937773004546 isocitrate dehydrogenase; Validated; Region: PRK07362 937773004547 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 937773004548 dimer interface [polypeptide binding]; other site 937773004549 Citrate synthase; Region: Citrate_synt; pfam00285 937773004550 active site 937773004551 citrylCoA binding site [chemical binding]; other site 937773004552 oxalacetate/citrate binding site [chemical binding]; other site 937773004553 coenzyme A binding site [chemical binding]; other site 937773004554 catalytic triad [active] 937773004555 pyruvate kinase; Provisional; Region: PRK06354 937773004556 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 937773004557 domain interfaces; other site 937773004558 active site 937773004559 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 937773004560 6-phosphofructokinase; Provisional; Region: PRK03202 937773004561 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 937773004562 active site 937773004563 ADP/pyrophosphate binding site [chemical binding]; other site 937773004564 dimerization interface [polypeptide binding]; other site 937773004565 allosteric effector site; other site 937773004566 fructose-1,6-bisphosphate binding site; other site 937773004567 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 937773004568 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 937773004569 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 937773004570 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 937773004571 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 937773004572 Malic enzyme, N-terminal domain; Region: malic; pfam00390 937773004573 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 937773004574 putative NAD(P) binding site [chemical binding]; other site 937773004575 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 937773004576 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 937773004577 active site 937773004578 PHP Thumb interface [polypeptide binding]; other site 937773004579 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 937773004580 generic binding surface I; other site 937773004581 generic binding surface II; other site 937773004582 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 937773004583 DHH family; Region: DHH; pfam01368 937773004584 DHHA1 domain; Region: DHHA1; pfam02272 937773004585 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 937773004586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 937773004587 DNA-binding site [nucleotide binding]; DNA binding site 937773004588 DRTGG domain; Region: DRTGG; pfam07085 937773004589 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 937773004590 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 937773004591 Ligand Binding Site [chemical binding]; other site 937773004592 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 937773004593 metal-dependent hydrolase; Provisional; Region: PRK00685 937773004594 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 937773004595 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 937773004596 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 937773004597 active site 937773004598 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 937773004599 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 937773004600 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 937773004601 hexamer interface [polypeptide binding]; other site 937773004602 ligand binding site [chemical binding]; other site 937773004603 putative active site [active] 937773004604 NAD(P) binding site [chemical binding]; other site 937773004605 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 937773004606 Ligand Binding Site [chemical binding]; other site 937773004607 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 937773004608 propionate/acetate kinase; Provisional; Region: PRK12379 937773004609 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 937773004610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004611 S-adenosylmethionine binding site [chemical binding]; other site 937773004612 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 937773004613 dimer interface [polypeptide binding]; other site 937773004614 catalytic triad [active] 937773004615 peroxidatic and resolving cysteines [active] 937773004616 RDD family; Region: RDD; pfam06271 937773004617 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 937773004618 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 937773004619 tandem repeat interface [polypeptide binding]; other site 937773004620 oligomer interface [polypeptide binding]; other site 937773004621 active site residues [active] 937773004622 hypothetical protein; Provisional; Region: PRK10621 937773004623 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 937773004624 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 937773004625 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 937773004626 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 937773004627 Ligand Binding Site [chemical binding]; other site 937773004628 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 937773004629 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 937773004630 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773004631 catalytic residue [active] 937773004632 septation ring formation regulator EzrA; Provisional; Region: PRK04778 937773004633 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 937773004634 GAF domain; Region: GAF_2; pfam13185 937773004635 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 937773004636 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 937773004637 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773004638 RNA binding surface [nucleotide binding]; other site 937773004639 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 937773004640 Sm and related proteins; Region: Sm_like; cl00259 937773004641 Sm1 motif; other site 937773004642 aldose dehydrogenase; Validated; Region: PRK06398 937773004643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 937773004644 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 937773004645 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 937773004646 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 937773004647 Phosphotransferase enzyme family; Region: APH; pfam01636 937773004648 active site 937773004649 ATP binding site [chemical binding]; other site 937773004650 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 937773004651 substrate binding site [chemical binding]; other site 937773004652 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 937773004653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773004654 Coenzyme A binding pocket [chemical binding]; other site 937773004655 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 937773004656 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 937773004657 MAP domain; Region: MAP; pfam03642 937773004658 MAP domain; Region: MAP; pfam03642 937773004659 ornithine cyclodeaminase; Validated; Region: PRK08618 937773004660 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 937773004661 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 937773004662 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 937773004663 active site 937773004664 catalytic site [active] 937773004665 OsmC-like protein; Region: OsmC; cl00767 937773004666 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 937773004667 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773004668 catalytic residue [active] 937773004669 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 937773004670 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 937773004671 ligand binding site [chemical binding]; other site 937773004672 NAD binding site [chemical binding]; other site 937773004673 dimerization interface [polypeptide binding]; other site 937773004674 catalytic site [active] 937773004675 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 937773004676 putative L-serine binding site [chemical binding]; other site 937773004677 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 937773004678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773004679 motif II; other site 937773004680 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 937773004681 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 937773004682 putative acyl-acceptor binding pocket; other site 937773004683 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 937773004684 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 937773004685 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 937773004686 protein binding site [polypeptide binding]; other site 937773004687 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 937773004688 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 937773004689 active site 937773004690 HIGH motif; other site 937773004691 dimer interface [polypeptide binding]; other site 937773004692 KMSKS motif; other site 937773004693 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773004694 RNA binding surface [nucleotide binding]; other site 937773004695 glycosyltransferase; Provisional; Region: PRK13481 937773004696 Transglycosylase; Region: Transgly; pfam00912 937773004697 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 937773004698 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 937773004699 Potassium binding sites [ion binding]; other site 937773004700 Cesium cation binding sites [ion binding]; other site 937773004701 acetyl-CoA synthetase; Provisional; Region: PRK04319 937773004702 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 937773004703 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 937773004704 active site 937773004705 acyl-activating enzyme (AAE) consensus motif; other site 937773004706 putative CoA binding site [chemical binding]; other site 937773004707 AMP binding site [chemical binding]; other site 937773004708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773004709 Coenzyme A binding pocket [chemical binding]; other site 937773004710 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 937773004711 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 937773004712 active site 937773004713 Zn binding site [ion binding]; other site 937773004714 catabolite control protein A; Region: ccpA; TIGR01481 937773004715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773004716 DNA binding site [nucleotide binding] 937773004717 domain linker motif; other site 937773004718 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 937773004719 dimerization interface [polypeptide binding]; other site 937773004720 effector binding site; other site 937773004721 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 937773004722 Chorismate mutase type II; Region: CM_2; cl00693 937773004723 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 937773004724 YtxH-like protein; Region: YtxH; pfam12732 937773004725 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 937773004726 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 937773004727 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 937773004728 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773004729 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773004730 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 937773004731 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 937773004732 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 937773004733 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 937773004734 putative tRNA-binding site [nucleotide binding]; other site 937773004735 hypothetical protein; Provisional; Region: PRK13668 937773004736 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773004737 catalytic residues [active] 937773004738 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 937773004739 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 937773004740 oligomer interface [polypeptide binding]; other site 937773004741 active site 937773004742 metal binding site [ion binding]; metal-binding site 937773004743 Predicted small secreted protein [Function unknown]; Region: COG5584 937773004744 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 937773004745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004746 S-adenosylmethionine binding site [chemical binding]; other site 937773004747 Phosphotransferase enzyme family; Region: APH; pfam01636 937773004748 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 937773004749 active site 937773004750 substrate binding site [chemical binding]; other site 937773004751 ATP binding site [chemical binding]; other site 937773004752 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 937773004753 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 937773004754 homodimer interface [polypeptide binding]; other site 937773004755 substrate-cofactor binding pocket; other site 937773004756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773004757 catalytic residue [active] 937773004758 dipeptidase PepV; Reviewed; Region: PRK07318 937773004759 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 937773004760 active site 937773004761 metal binding site [ion binding]; metal-binding site 937773004762 YtxH-like protein; Region: YtxH; cl02079 937773004763 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 937773004764 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 937773004765 RNA binding surface [nucleotide binding]; other site 937773004766 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 937773004767 active site 937773004768 uracil binding [chemical binding]; other site 937773004769 stage V sporulation protein B; Region: spore_V_B; TIGR02900 937773004770 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 937773004771 HI0933-like protein; Region: HI0933_like; pfam03486 937773004772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 937773004773 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 937773004774 active site residue [active] 937773004775 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 937773004776 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 937773004777 HIGH motif; other site 937773004778 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 937773004779 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 937773004780 active site 937773004781 KMSKS motif; other site 937773004782 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 937773004783 tRNA binding surface [nucleotide binding]; other site 937773004784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773004785 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773004786 putative substrate translocation pore; other site 937773004787 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 937773004788 Methyltransferase domain; Region: Methyltransf_31; pfam13847 937773004789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773004790 S-adenosylmethionine binding site [chemical binding]; other site 937773004791 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 937773004792 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 937773004793 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 937773004794 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773004795 NAD binding site [chemical binding]; other site 937773004796 dimer interface [polypeptide binding]; other site 937773004797 substrate binding site [chemical binding]; other site 937773004798 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 937773004799 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 937773004800 Proline dehydrogenase; Region: Pro_dh; cl03282 937773004801 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 937773004802 homopentamer interface [polypeptide binding]; other site 937773004803 active site 937773004804 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 937773004805 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 937773004806 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 937773004807 dimerization interface [polypeptide binding]; other site 937773004808 active site 937773004809 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 937773004810 Lumazine binding domain; Region: Lum_binding; pfam00677 937773004811 Lumazine binding domain; Region: Lum_binding; pfam00677 937773004812 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 937773004813 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 937773004814 catalytic motif [active] 937773004815 Zn binding site [ion binding]; other site 937773004816 RibD C-terminal domain; Region: RibD_C; pfam01872 937773004817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 937773004818 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 937773004819 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 937773004820 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 937773004821 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 937773004822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 937773004823 DNA binding residues [nucleotide binding] 937773004824 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 937773004825 active site 937773004826 intersubunit interactions; other site 937773004827 catalytic residue [active] 937773004828 CrcB-like protein; Region: CRCB; cl09114 937773004829 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 937773004830 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 937773004831 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 937773004832 active site 937773004833 catalytic tetrad [active] 937773004834 S-adenosylmethionine synthetase; Validated; Region: PRK05250 937773004835 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 937773004836 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 937773004837 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 937773004838 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 937773004839 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 937773004840 active site 937773004841 substrate-binding site [chemical binding]; other site 937773004842 metal-binding site [ion binding] 937773004843 ATP binding site [chemical binding]; other site 937773004844 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 937773004845 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 937773004846 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 937773004847 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 937773004848 nudix motif; other site 937773004849 Haemolytic domain; Region: Haemolytic; pfam01809 937773004850 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 937773004851 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 937773004852 metal binding site [ion binding]; metal-binding site 937773004853 substrate binding pocket [chemical binding]; other site 937773004854 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 937773004855 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 937773004856 acyl-activating enzyme (AAE) consensus motif; other site 937773004857 putative AMP binding site [chemical binding]; other site 937773004858 putative active site [active] 937773004859 putative CoA binding site [chemical binding]; other site 937773004860 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 937773004861 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 937773004862 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 937773004863 intersubunit interface [polypeptide binding]; other site 937773004864 active site 937773004865 Zn2+ binding site [ion binding]; other site 937773004866 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 937773004867 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 937773004868 AP (apurinic/apyrimidinic) site pocket; other site 937773004869 DNA interaction; other site 937773004870 Metal-binding active site; metal-binding site 937773004871 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 937773004872 active site 937773004873 dimer interface [polypeptide binding]; other site 937773004874 magnesium binding site [ion binding]; other site 937773004875 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773004876 active site 937773004877 phosphorylation site [posttranslational modification] 937773004878 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 937773004879 active site 937773004880 P-loop; other site 937773004881 phosphorylation site [posttranslational modification] 937773004882 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 937773004883 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 937773004884 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 937773004885 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 937773004886 catalytic core [active] 937773004887 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 937773004888 beta-channel forming cytolysin; Region: hlyII; TIGR01002 937773004889 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 937773004890 Sm and related proteins; Region: Sm_like; cl00259 937773004891 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 937773004892 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 937773004893 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 937773004894 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 937773004895 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 937773004896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 937773004897 ferrochelatase; Provisional; Region: PRK12435 937773004898 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 937773004899 C-terminal domain interface [polypeptide binding]; other site 937773004900 active site 937773004901 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 937773004902 active site 937773004903 N-terminal domain interface [polypeptide binding]; other site 937773004904 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 937773004905 substrate binding site [chemical binding]; other site 937773004906 active site 937773004907 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 937773004908 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 937773004909 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 937773004910 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 937773004911 Walker A/P-loop; other site 937773004912 ATP binding site [chemical binding]; other site 937773004913 Q-loop/lid; other site 937773004914 ABC transporter signature motif; other site 937773004915 Walker B; other site 937773004916 D-loop; other site 937773004917 H-loop/switch region; other site 937773004918 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 937773004919 HIT family signature motif; other site 937773004920 catalytic residue [active] 937773004921 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 937773004922 transcriptional regulator Hpr; Provisional; Region: PRK13777 937773004923 MarR family; Region: MarR; pfam01047 937773004924 MarR family; Region: MarR_2; cl17246 937773004925 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 937773004926 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 937773004927 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 937773004928 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 937773004929 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 937773004930 generic binding surface II; other site 937773004931 generic binding surface I; other site 937773004932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 937773004933 Zn2+ binding site [ion binding]; other site 937773004934 Mg2+ binding site [ion binding]; other site 937773004935 Uncharacterized conserved protein [Function unknown]; Region: COG4717 937773004936 P-loop containing region of AAA domain; Region: AAA_29; cl17516 937773004937 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 937773004938 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 937773004939 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 937773004940 active site 937773004941 metal binding site [ion binding]; metal-binding site 937773004942 DNA binding site [nucleotide binding] 937773004943 hypothetical protein; Provisional; Region: PRK13676 937773004944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 937773004945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773004946 non-specific DNA binding site [nucleotide binding]; other site 937773004947 salt bridge; other site 937773004948 sequence-specific DNA binding site [nucleotide binding]; other site 937773004949 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 937773004950 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 937773004951 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 937773004952 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 937773004953 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 937773004954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773004955 active site 937773004956 phosphorylation site [posttranslational modification] 937773004957 intermolecular recognition site; other site 937773004958 dimerization interface [polypeptide binding]; other site 937773004959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 937773004960 DNA binding residues [nucleotide binding] 937773004961 dimerization interface [polypeptide binding]; other site 937773004962 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 937773004963 GAF domain; Region: GAF; pfam01590 937773004964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 937773004965 Histidine kinase; Region: HisKA_3; pfam07730 937773004966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773004967 ATP binding site [chemical binding]; other site 937773004968 Mg2+ binding site [ion binding]; other site 937773004969 G-X-G motif; other site 937773004970 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 937773004971 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 937773004972 active site 937773004973 polyphosphate kinase; Provisional; Region: PRK05443 937773004974 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 937773004975 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 937773004976 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 937773004977 putative domain interface [polypeptide binding]; other site 937773004978 putative active site [active] 937773004979 catalytic site [active] 937773004980 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 937773004981 putative domain interface [polypeptide binding]; other site 937773004982 putative active site [active] 937773004983 catalytic site [active] 937773004984 exopolyphosphatase; Region: exo_poly_only; TIGR03706 937773004985 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 937773004986 nucleotide binding site [chemical binding]; other site 937773004987 fumarate hydratase; Reviewed; Region: fumC; PRK00485 937773004988 Class II fumarases; Region: Fumarase_classII; cd01362 937773004989 active site 937773004990 tetramer interface [polypeptide binding]; other site 937773004991 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 937773004992 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 937773004993 active site 937773004994 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 937773004995 epoxyqueuosine reductase; Region: TIGR00276 937773004996 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 937773004997 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 937773004998 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 937773004999 Walker A/P-loop; other site 937773005000 ATP binding site [chemical binding]; other site 937773005001 Q-loop/lid; other site 937773005002 ABC transporter signature motif; other site 937773005003 Walker B; other site 937773005004 D-loop; other site 937773005005 H-loop/switch region; other site 937773005006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 937773005007 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 937773005008 substrate binding pocket [chemical binding]; other site 937773005009 membrane-bound complex binding site; other site 937773005010 hinge residues; other site 937773005011 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 937773005012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773005013 dimer interface [polypeptide binding]; other site 937773005014 conserved gate region; other site 937773005015 ABC-ATPase subunit interface; other site 937773005016 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 937773005017 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 937773005018 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 937773005019 ferric uptake regulator; Provisional; Region: fur; PRK09462 937773005020 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 937773005021 metal binding site 2 [ion binding]; metal-binding site 937773005022 putative DNA binding helix; other site 937773005023 metal binding site 1 [ion binding]; metal-binding site 937773005024 dimer interface [polypeptide binding]; other site 937773005025 structural Zn2+ binding site [ion binding]; other site 937773005026 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 937773005027 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 937773005028 putative ligand binding site [chemical binding]; other site 937773005029 NAD binding site [chemical binding]; other site 937773005030 catalytic site [active] 937773005031 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 937773005032 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 937773005033 catalytic triad [active] 937773005034 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 937773005035 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 937773005036 inhibitor-cofactor binding pocket; inhibition site 937773005037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773005038 catalytic residue [active] 937773005039 Predicted membrane protein [Function unknown]; Region: COG4129 937773005040 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 937773005041 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 937773005042 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 937773005043 active site 937773005044 FMN binding site [chemical binding]; other site 937773005045 substrate binding site [chemical binding]; other site 937773005046 3Fe-4S cluster binding site [ion binding]; other site 937773005047 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 937773005048 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 937773005049 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 937773005050 Walker A/P-loop; other site 937773005051 ATP binding site [chemical binding]; other site 937773005052 Q-loop/lid; other site 937773005053 ABC transporter signature motif; other site 937773005054 Walker B; other site 937773005055 D-loop; other site 937773005056 H-loop/switch region; other site 937773005057 hypothetical protein; Provisional; Region: PRK13662 937773005058 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 937773005059 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 937773005060 minor groove reading motif; other site 937773005061 helix-hairpin-helix signature motif; other site 937773005062 substrate binding pocket [chemical binding]; other site 937773005063 active site 937773005064 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 937773005065 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 937773005066 DNA binding and oxoG recognition site [nucleotide binding] 937773005067 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 937773005068 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 937773005069 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 937773005070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773005071 Walker A/P-loop; other site 937773005072 ATP binding site [chemical binding]; other site 937773005073 ABC transporter signature motif; other site 937773005074 Walker B; other site 937773005075 D-loop; other site 937773005076 H-loop/switch region; other site 937773005077 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 937773005078 RecX family; Region: RecX; cl00936 937773005079 glycosyltransferase; Provisional; Region: PRK13481 937773005080 Transglycosylase; Region: Transgly; pfam00912 937773005081 pyruvate oxidase; Provisional; Region: PRK08611 937773005082 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 937773005083 PYR/PP interface [polypeptide binding]; other site 937773005084 tetramer interface [polypeptide binding]; other site 937773005085 dimer interface [polypeptide binding]; other site 937773005086 TPP binding site [chemical binding]; other site 937773005087 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 937773005088 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 937773005089 TPP-binding site [chemical binding]; other site 937773005090 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 937773005091 intracellular protease, PfpI family; Region: PfpI; TIGR01382 937773005092 proposed catalytic triad [active] 937773005093 conserved cys residue [active] 937773005094 Radical SAM superfamily; Region: Radical_SAM; pfam04055 937773005095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773005096 FeS/SAM binding site; other site 937773005097 YfkB-like domain; Region: YfkB; pfam08756 937773005098 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 937773005099 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 937773005100 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 937773005101 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 937773005102 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 937773005103 Low molecular weight phosphatase family; Region: LMWPc; cd00115 937773005104 active site 937773005105 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 937773005106 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 937773005107 active site clefts [active] 937773005108 zinc binding site [ion binding]; other site 937773005109 dimer interface [polypeptide binding]; other site 937773005110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 937773005111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773005112 active site 937773005113 phosphorylation site [posttranslational modification] 937773005114 intermolecular recognition site; other site 937773005115 dimerization interface [polypeptide binding]; other site 937773005116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 937773005117 DNA binding residues [nucleotide binding] 937773005118 dimerization interface [polypeptide binding]; other site 937773005119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 937773005120 Histidine kinase; Region: HisKA_3; pfam07730 937773005121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773005122 ATP binding site [chemical binding]; other site 937773005123 Mg2+ binding site [ion binding]; other site 937773005124 G-X-G motif; other site 937773005125 Predicted membrane protein [Function unknown]; Region: COG4758 937773005126 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 937773005127 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 937773005128 active site 937773005129 Predicted membrane protein [Function unknown]; Region: COG4129 937773005130 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 937773005131 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 937773005132 catalytic triad [active] 937773005133 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 937773005134 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773005135 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 937773005136 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 937773005137 Ferritin-like domain; Region: Ferritin; pfam00210 937773005138 ferroxidase diiron center [ion binding]; other site 937773005139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 937773005140 Transposase; Region: DDE_Tnp_ISL3; pfam01610 937773005141 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 937773005142 active site 937773005143 catalytic site [active] 937773005144 substrate binding site [chemical binding]; other site 937773005145 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 937773005146 active site 937773005147 DNA polymerase IV; Validated; Region: PRK02406 937773005148 DNA binding site [nucleotide binding] 937773005149 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 937773005150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773005151 Radical SAM superfamily; Region: Radical_SAM; pfam04055 937773005152 FeS/SAM binding site; other site 937773005153 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 937773005154 TRAM domain; Region: TRAM; cl01282 937773005155 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 937773005156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773005157 S-adenosylmethionine binding site [chemical binding]; other site 937773005158 putative lipid kinase; Reviewed; Region: PRK13337 937773005159 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 937773005160 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 937773005161 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 937773005162 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 937773005163 GatB domain; Region: GatB_Yqey; pfam02637 937773005164 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 937773005165 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 937773005166 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 937773005167 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 937773005168 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 937773005169 Na binding site [ion binding]; other site 937773005170 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 937773005171 putative dimer interface [polypeptide binding]; other site 937773005172 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 937773005173 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 937773005174 putative dimer interface [polypeptide binding]; other site 937773005175 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 937773005176 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 937773005177 nucleotide binding pocket [chemical binding]; other site 937773005178 K-X-D-G motif; other site 937773005179 catalytic site [active] 937773005180 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 937773005181 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 937773005182 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 937773005183 Dimer interface [polypeptide binding]; other site 937773005184 BRCT sequence motif; other site 937773005185 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 937773005186 Part of AAA domain; Region: AAA_19; pfam13245 937773005187 Family description; Region: UvrD_C_2; pfam13538 937773005188 PcrB family; Region: PcrB; pfam01884 937773005189 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 937773005190 substrate binding site [chemical binding]; other site 937773005191 putative active site [active] 937773005192 dimer interface [polypeptide binding]; other site 937773005193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 937773005194 adenylosuccinate lyase; Provisional; Region: PRK07492 937773005195 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 937773005196 tetramer interface [polypeptide binding]; other site 937773005197 active site 937773005198 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 937773005199 NETI protein; Region: NETI; pfam14044 937773005200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 937773005201 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 937773005202 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 937773005203 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 937773005204 homodimer interface [polypeptide binding]; other site 937773005205 NAD binding pocket [chemical binding]; other site 937773005206 ATP binding pocket [chemical binding]; other site 937773005207 Mg binding site [ion binding]; other site 937773005208 active-site loop [active] 937773005209 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 937773005210 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 937773005211 active site 937773005212 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 937773005213 active site 937773005214 dimer interface [polypeptide binding]; other site 937773005215 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 937773005216 Prephenate dehydratase; Region: PDT; pfam00800 937773005217 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 937773005218 putative L-Phe binding site [chemical binding]; other site 937773005219 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 937773005220 Isochorismatase family; Region: Isochorismatase; pfam00857 937773005221 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 937773005222 catalytic triad [active] 937773005223 conserved cis-peptide bond; other site 937773005224 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 937773005225 DHH family; Region: DHH; pfam01368 937773005226 DHHA2 domain; Region: DHHA2; pfam02833 937773005227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773005228 Coenzyme A binding pocket [chemical binding]; other site 937773005229 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 937773005230 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 937773005231 NAD(P) binding site [chemical binding]; other site 937773005232 catalytic residues [active] 937773005233 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 937773005234 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 937773005235 active site 937773005236 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 937773005237 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 937773005238 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 937773005239 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 937773005240 fructuronate transporter; Provisional; Region: PRK10034; cl15264 937773005241 gluconate transporter; Region: gntP; TIGR00791 937773005242 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 937773005243 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 937773005244 N- and C-terminal domain interface [polypeptide binding]; other site 937773005245 active site 937773005246 catalytic site [active] 937773005247 metal binding site [ion binding]; metal-binding site 937773005248 carbohydrate binding site [chemical binding]; other site 937773005249 ATP binding site [chemical binding]; other site 937773005250 Transcriptional regulators [Transcription]; Region: GntR; COG1802 937773005251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773005252 DNA-binding site [nucleotide binding]; DNA binding site 937773005253 FCD domain; Region: FCD; pfam07729 937773005254 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 937773005255 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 937773005256 Walker A/P-loop; other site 937773005257 ATP binding site [chemical binding]; other site 937773005258 Q-loop/lid; other site 937773005259 ABC transporter signature motif; other site 937773005260 Walker B; other site 937773005261 D-loop; other site 937773005262 H-loop/switch region; other site 937773005263 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 937773005264 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773005265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773005266 homodimer interface [polypeptide binding]; other site 937773005267 catalytic residue [active] 937773005268 Radical SAM superfamily; Region: Radical_SAM; pfam04055 937773005269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773005270 FeS/SAM binding site; other site 937773005271 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 937773005272 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 937773005273 active site 937773005274 DNA binding site [nucleotide binding] 937773005275 acetylornithine deacetylase; Validated; Region: PRK08596 937773005276 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 937773005277 metal binding site [ion binding]; metal-binding site 937773005278 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 937773005279 active site 937773005280 catalytic residues [active] 937773005281 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 937773005282 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 937773005283 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 937773005284 ring oligomerisation interface [polypeptide binding]; other site 937773005285 ATP/Mg binding site [chemical binding]; other site 937773005286 stacking interactions; other site 937773005287 hinge regions; other site 937773005288 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 937773005289 oligomerisation interface [polypeptide binding]; other site 937773005290 mobile loop; other site 937773005291 roof hairpin; other site 937773005292 CAAX protease self-immunity; Region: Abi; pfam02517 937773005293 sporozoite surface protein 2 (SSP2); Provisional; Region: PTZ00441 937773005294 Predicted amidohydrolase [General function prediction only]; Region: COG0388 937773005295 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 937773005296 putative active site [active] 937773005297 catalytic triad [active] 937773005298 putative dimer interface [polypeptide binding]; other site 937773005299 Accessory gene regulator B; Region: AgrB; smart00793 937773005300 Staphylococcal AgrD protein; Region: AgrD; smart00794 937773005301 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 937773005302 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 937773005303 ATP binding site [chemical binding]; other site 937773005304 Mg2+ binding site [ion binding]; other site 937773005305 G-X-G motif; other site 937773005306 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 937773005307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773005308 active site 937773005309 phosphorylation site [posttranslational modification] 937773005310 intermolecular recognition site; other site 937773005311 dimerization interface [polypeptide binding]; other site 937773005312 LytTr DNA-binding domain; Region: LytTR; pfam04397 937773005313 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 937773005314 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 937773005315 putative substrate binding site [chemical binding]; other site 937773005316 putative ATP binding site [chemical binding]; other site 937773005317 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 937773005318 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 937773005319 substrate binding [chemical binding]; other site 937773005320 active site 937773005321 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 937773005322 Transcriptional regulators [Transcription]; Region: PurR; COG1609 937773005323 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773005324 DNA binding site [nucleotide binding] 937773005325 domain linker motif; other site 937773005326 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 937773005327 dimerization interface [polypeptide binding]; other site 937773005328 ligand binding site [chemical binding]; other site 937773005329 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 937773005330 Cytochrome P450; Region: p450; cl12078 937773005331 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773005332 MarR family; Region: MarR; pfam01047 937773005333 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 937773005334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005335 putative substrate translocation pore; other site 937773005336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005337 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 937773005338 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 937773005339 CoA binding domain; Region: CoA_binding; pfam02629 937773005340 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 937773005341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773005342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773005343 ABC transporter; Region: ABC_tran_2; pfam12848 937773005344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773005345 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 937773005346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773005347 Walker A/P-loop; other site 937773005348 ATP binding site [chemical binding]; other site 937773005349 Q-loop/lid; other site 937773005350 ABC transporter signature motif; other site 937773005351 Walker B; other site 937773005352 D-loop; other site 937773005353 H-loop/switch region; other site 937773005354 UGMP family protein; Validated; Region: PRK09604 937773005355 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 937773005356 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 937773005357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773005358 Coenzyme A binding pocket [chemical binding]; other site 937773005359 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 937773005360 Glycoprotease family; Region: Peptidase_M22; pfam00814 937773005361 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 937773005362 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 937773005363 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 937773005364 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 937773005365 PYR/PP interface [polypeptide binding]; other site 937773005366 dimer interface [polypeptide binding]; other site 937773005367 TPP binding site [chemical binding]; other site 937773005368 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 937773005369 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 937773005370 TPP-binding site [chemical binding]; other site 937773005371 dimer interface [polypeptide binding]; other site 937773005372 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 937773005373 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 937773005374 ketol-acid reductoisomerase; Provisional; Region: PRK05479 937773005375 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 937773005376 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 937773005377 2-isopropylmalate synthase; Validated; Region: PRK00915 937773005378 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 937773005379 active site 937773005380 catalytic residues [active] 937773005381 metal binding site [ion binding]; metal-binding site 937773005382 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 937773005383 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 937773005384 tartrate dehydrogenase; Region: TTC; TIGR02089 937773005385 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 937773005386 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 937773005387 substrate binding site [chemical binding]; other site 937773005388 ligand binding site [chemical binding]; other site 937773005389 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 937773005390 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 937773005391 substrate binding site [chemical binding]; other site 937773005392 threonine dehydratase; Validated; Region: PRK08639 937773005393 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 937773005394 tetramer interface [polypeptide binding]; other site 937773005395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773005396 catalytic residue [active] 937773005397 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 937773005398 putative Ile/Val binding site [chemical binding]; other site 937773005399 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773005400 hypothetical protein; Provisional; Region: PRK04351 937773005401 SprT homologues; Region: SprT; cl01182 937773005402 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 937773005403 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 937773005404 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 937773005405 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 937773005406 RNA binding site [nucleotide binding]; other site 937773005407 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 937773005408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 937773005409 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 937773005410 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 937773005411 DNA binding residues [nucleotide binding] 937773005412 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 937773005413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773005414 ATP binding site [chemical binding]; other site 937773005415 Mg2+ binding site [ion binding]; other site 937773005416 G-X-G motif; other site 937773005417 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 937773005418 anti sigma factor interaction site; other site 937773005419 regulatory phosphorylation site [posttranslational modification]; other site 937773005420 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 937773005421 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 937773005422 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 937773005423 PemK-like protein; Region: PemK; pfam02452 937773005424 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 937773005425 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 937773005426 active site 937773005427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773005428 dimer interface [polypeptide binding]; other site 937773005429 substrate binding site [chemical binding]; other site 937773005430 catalytic residues [active] 937773005431 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 937773005432 Bacterial PH domain; Region: DUF304; pfam03703 937773005433 Predicted membrane protein [Function unknown]; Region: COG3428 937773005434 Bacterial PH domain; Region: DUF304; pfam03703 937773005435 Bacterial PH domain; Region: DUF304; pfam03703 937773005436 Bacterial PH domain; Region: DUF304; cl01348 937773005437 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 937773005438 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 937773005439 ATP binding site [chemical binding]; other site 937773005440 Mg++ binding site [ion binding]; other site 937773005441 motif III; other site 937773005442 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 937773005443 nucleotide binding region [chemical binding]; other site 937773005444 ATP-binding site [chemical binding]; other site 937773005445 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 937773005446 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 937773005447 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 937773005448 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 937773005449 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 937773005450 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 937773005451 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 937773005452 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 937773005453 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 937773005454 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 937773005455 metal-binding site [ion binding] 937773005456 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773005457 Soluble P-type ATPase [General function prediction only]; Region: COG4087 937773005458 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 937773005459 metal-binding site [ion binding] 937773005460 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 937773005461 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 937773005462 putative homodimer interface [polypeptide binding]; other site 937773005463 putative homotetramer interface [polypeptide binding]; other site 937773005464 allosteric switch controlling residues; other site 937773005465 putative metal binding site [ion binding]; other site 937773005466 putative homodimer-homodimer interface [polypeptide binding]; other site 937773005467 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 937773005468 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 937773005469 putative active site [active] 937773005470 catalytic site [active] 937773005471 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 937773005472 putative active site [active] 937773005473 catalytic site [active] 937773005474 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 937773005475 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 937773005476 Zn2+ binding site [ion binding]; other site 937773005477 Mg2+ binding site [ion binding]; other site 937773005478 OxaA-like protein precursor; Provisional; Region: PRK02463 937773005479 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 937773005480 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 937773005481 thiamine phosphate binding site [chemical binding]; other site 937773005482 active site 937773005483 pyrophosphate binding site [ion binding]; other site 937773005484 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 937773005485 substrate binding site [chemical binding]; other site 937773005486 multimerization interface [polypeptide binding]; other site 937773005487 ATP binding site [chemical binding]; other site 937773005488 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 937773005489 dimer interface [polypeptide binding]; other site 937773005490 substrate binding site [chemical binding]; other site 937773005491 ATP binding site [chemical binding]; other site 937773005492 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 937773005493 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 937773005494 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 937773005495 dimer interface [polypeptide binding]; other site 937773005496 ssDNA binding site [nucleotide binding]; other site 937773005497 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773005498 YwpF-like protein; Region: YwpF; pfam14183 937773005499 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 937773005500 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 937773005501 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 937773005502 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 937773005503 hinge; other site 937773005504 active site 937773005505 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 937773005506 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 937773005507 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 937773005508 gamma subunit interface [polypeptide binding]; other site 937773005509 epsilon subunit interface [polypeptide binding]; other site 937773005510 LBP interface [polypeptide binding]; other site 937773005511 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 937773005512 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 937773005513 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 937773005514 alpha subunit interaction interface [polypeptide binding]; other site 937773005515 Walker A motif; other site 937773005516 ATP binding site [chemical binding]; other site 937773005517 Walker B motif; other site 937773005518 inhibitor binding site; inhibition site 937773005519 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 937773005520 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 937773005521 core domain interface [polypeptide binding]; other site 937773005522 delta subunit interface [polypeptide binding]; other site 937773005523 epsilon subunit interface [polypeptide binding]; other site 937773005524 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 937773005525 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 937773005526 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 937773005527 beta subunit interaction interface [polypeptide binding]; other site 937773005528 Walker A motif; other site 937773005529 ATP binding site [chemical binding]; other site 937773005530 Walker B motif; other site 937773005531 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 937773005532 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 937773005533 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 937773005534 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 937773005535 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 937773005536 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 937773005537 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 937773005538 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 937773005539 ATP synthase I chain; Region: ATP_synt_I; pfam03899 937773005540 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 937773005541 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 937773005542 active site 937773005543 homodimer interface [polypeptide binding]; other site 937773005544 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 937773005545 active site 937773005546 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 937773005547 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 937773005548 dimer interface [polypeptide binding]; other site 937773005549 active site 937773005550 glycine-pyridoxal phosphate binding site [chemical binding]; other site 937773005551 folate binding site [chemical binding]; other site 937773005552 hypothetical protein; Provisional; Region: PRK13690 937773005553 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 937773005554 Low molecular weight phosphatase family; Region: LMWPc; cd00115 937773005555 active site 937773005556 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 937773005557 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 937773005558 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 937773005559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773005560 S-adenosylmethionine binding site [chemical binding]; other site 937773005561 peptide chain release factor 1; Validated; Region: prfA; PRK00591 937773005562 This domain is found in peptide chain release factors; Region: PCRF; smart00937 937773005563 RF-1 domain; Region: RF-1; pfam00472 937773005564 thymidine kinase; Provisional; Region: PRK04296 937773005565 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 937773005566 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 937773005567 transcription termination factor Rho; Provisional; Region: rho; PRK09376 937773005568 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 937773005569 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 937773005570 RNA binding site [nucleotide binding]; other site 937773005571 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 937773005572 Walker A motif; other site 937773005573 ATP binding site [chemical binding]; other site 937773005574 Walker B motif; other site 937773005575 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 937773005576 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 937773005577 NAD binding site [chemical binding]; other site 937773005578 catalytic residues [active] 937773005579 Predicted transcriptional regulators [Transcription]; Region: COG1733 937773005580 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 937773005581 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 937773005582 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 937773005583 hinge; other site 937773005584 active site 937773005585 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 937773005586 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 937773005587 intersubunit interface [polypeptide binding]; other site 937773005588 active site 937773005589 zinc binding site [ion binding]; other site 937773005590 Na+ binding site [ion binding]; other site 937773005591 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 937773005592 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 937773005593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005594 putative substrate translocation pore; other site 937773005595 CTP synthetase; Validated; Region: pyrG; PRK05380 937773005596 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 937773005597 Catalytic site [active] 937773005598 active site 937773005599 UTP binding site [chemical binding]; other site 937773005600 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 937773005601 active site 937773005602 putative oxyanion hole; other site 937773005603 catalytic triad [active] 937773005604 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 937773005605 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 937773005606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773005607 Coenzyme A binding pocket [chemical binding]; other site 937773005608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 937773005609 BCCT family transporter; Region: BCCT; pfam02028 937773005610 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773005611 pantothenate kinase; Provisional; Region: PRK13317 937773005612 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 937773005613 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 937773005614 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 937773005615 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 937773005616 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 937773005617 metal binding site [ion binding]; metal-binding site 937773005618 S-ribosylhomocysteinase; Provisional; Region: PRK02260 937773005619 Predicted membrane protein [Function unknown]; Region: COG4270 937773005620 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 937773005621 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 937773005622 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 937773005623 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 937773005624 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 937773005625 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 937773005626 Protein of unknown function, DUF393; Region: DUF393; cl01136 937773005627 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 937773005628 EVE domain; Region: EVE; cl00728 937773005629 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 937773005630 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 937773005631 Transcriptional regulators [Transcription]; Region: FadR; COG2186 937773005632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773005633 DNA-binding site [nucleotide binding]; DNA binding site 937773005634 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 937773005635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773005636 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 937773005637 active site 937773005638 motif I; other site 937773005639 motif II; other site 937773005640 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 937773005641 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 937773005642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773005643 Walker A/P-loop; other site 937773005644 ATP binding site [chemical binding]; other site 937773005645 Q-loop/lid; other site 937773005646 ABC transporter signature motif; other site 937773005647 Walker B; other site 937773005648 D-loop; other site 937773005649 H-loop/switch region; other site 937773005650 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 937773005651 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 937773005652 glutaminase active site [active] 937773005653 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 937773005654 dimer interface [polypeptide binding]; other site 937773005655 active site 937773005656 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 937773005657 dimer interface [polypeptide binding]; other site 937773005658 active site 937773005659 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 937773005660 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 937773005661 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 937773005662 active site 937773005663 P-loop; other site 937773005664 phosphorylation site [posttranslational modification] 937773005665 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 937773005666 PRD domain; Region: PRD; pfam00874 937773005667 PRD domain; Region: PRD; pfam00874 937773005668 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 937773005669 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 937773005670 active site 937773005671 phosphorylation site [posttranslational modification] 937773005672 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773005673 active site 937773005674 phosphorylation site [posttranslational modification] 937773005675 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 937773005676 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 937773005677 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 937773005678 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 937773005679 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 937773005680 active site 937773005681 substrate binding site [chemical binding]; other site 937773005682 metal binding site [ion binding]; metal-binding site 937773005683 YbbR-like protein; Region: YbbR; pfam07949 937773005684 YbbR-like protein; Region: YbbR; pfam07949 937773005685 TIGR00159 family protein; Region: TIGR00159 937773005686 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 937773005687 Arginase family; Region: Arginase; cd09989 937773005688 active site 937773005689 Mn binding site [ion binding]; other site 937773005690 oligomer interface [polypeptide binding]; other site 937773005691 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 937773005692 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 937773005693 Walker A motif; other site 937773005694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773005696 putative substrate translocation pore; other site 937773005697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773005698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005699 putative substrate translocation pore; other site 937773005700 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 937773005701 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 937773005702 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 937773005703 active site 937773005704 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 937773005705 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 937773005706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 937773005707 Nucleoside recognition; Region: Gate; pfam07670 937773005708 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 937773005709 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773005710 ABC-ATPase subunit interface; other site 937773005711 dimer interface [polypeptide binding]; other site 937773005712 putative PBP binding regions; other site 937773005713 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 937773005714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 937773005715 ABC-ATPase subunit interface; other site 937773005716 dimer interface [polypeptide binding]; other site 937773005717 putative PBP binding regions; other site 937773005718 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 937773005719 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 937773005720 siderophore binding site; other site 937773005721 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 937773005722 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 937773005723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 937773005724 catalytic residue [active] 937773005725 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773005726 IucA / IucC family; Region: IucA_IucC; pfam04183 937773005727 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773005728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005729 putative substrate translocation pore; other site 937773005730 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 937773005731 IucA / IucC family; Region: IucA_IucC; pfam04183 937773005732 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 937773005733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773005734 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773005735 putative substrate translocation pore; other site 937773005736 Asp23 family; Region: Asp23; pfam03780 937773005737 Asp23 family; Region: Asp23; cl00574 937773005738 BCCT family transporter; Region: BCCT; pfam02028 937773005739 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 937773005740 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 937773005741 putative NAD(P) binding site [chemical binding]; other site 937773005742 dimer interface [polypeptide binding]; other site 937773005743 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 937773005744 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 937773005745 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 937773005746 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773005747 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773005748 ABC transporter; Region: ABC_tran_2; pfam12848 937773005749 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 937773005750 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 937773005751 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 937773005752 beta-galactosidase; Region: BGL; TIGR03356 937773005753 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 937773005754 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 937773005755 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 937773005756 active site 937773005757 P-loop; other site 937773005758 phosphorylation site [posttranslational modification] 937773005759 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 937773005760 active site 937773005761 methionine cluster; other site 937773005762 phosphorylation site [posttranslational modification] 937773005763 metal binding site [ion binding]; metal-binding site 937773005764 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 937773005765 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 937773005766 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 937773005767 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 937773005768 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 937773005769 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 937773005770 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 937773005771 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 937773005772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 937773005773 ATP binding site [chemical binding]; other site 937773005774 putative Mg++ binding site [ion binding]; other site 937773005775 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 937773005776 putative active site [active] 937773005777 catalytic site [active] 937773005778 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 937773005779 beta-lactamase TEM; Provisional; Region: PRK15442 937773005780 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 937773005781 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 937773005782 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 937773005783 Predicted transcriptional regulator [Transcription]; Region: COG3682 937773005784 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 937773005785 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 937773005786 catalytic residues [active] 937773005787 catalytic nucleophile [active] 937773005788 Presynaptic Site I dimer interface [polypeptide binding]; other site 937773005789 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 937773005790 Synaptic Flat tetramer interface [polypeptide binding]; other site 937773005791 Synaptic Site I dimer interface [polypeptide binding]; other site 937773005792 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 937773005793 DNA-binding interface [nucleotide binding]; DNA binding site 937773005794 Winged helix-turn helix; Region: HTH_29; pfam13551 937773005795 Helix-turn-helix domain; Region: HTH_28; pfam13518 937773005796 Homeodomain-like domain; Region: HTH_32; pfam13565 937773005797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 937773005798 Integrase core domain; Region: rve; pfam00665 937773005799 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 937773005800 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 937773005801 RES domain; Region: RES; pfam08808 937773005802 Isochorismatase family; Region: Isochorismatase; pfam00857 937773005803 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 937773005804 catalytic triad [active] 937773005805 conserved cis-peptide bond; other site 937773005806 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 937773005807 Divergent AAA domain; Region: AAA_4; pfam04326 937773005808 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 937773005809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 937773005810 putative DNA binding site [nucleotide binding]; other site 937773005811 putative Zn2+ binding site [ion binding]; other site 937773005812 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 937773005813 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 937773005814 23S rRNA interface [nucleotide binding]; other site 937773005815 L3 interface [polypeptide binding]; other site 937773005816 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 937773005817 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 937773005818 dimerization interface 3.5A [polypeptide binding]; other site 937773005819 active site 937773005820 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 937773005821 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 937773005822 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 937773005823 Walker A/P-loop; other site 937773005824 ATP binding site [chemical binding]; other site 937773005825 Q-loop/lid; other site 937773005826 ABC transporter signature motif; other site 937773005827 Walker B; other site 937773005828 D-loop; other site 937773005829 H-loop/switch region; other site 937773005830 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 937773005831 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 937773005832 Walker A/P-loop; other site 937773005833 ATP binding site [chemical binding]; other site 937773005834 Q-loop/lid; other site 937773005835 ABC transporter signature motif; other site 937773005836 Walker B; other site 937773005837 D-loop; other site 937773005838 H-loop/switch region; other site 937773005839 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 937773005840 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 937773005841 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 937773005842 alphaNTD homodimer interface [polypeptide binding]; other site 937773005843 alphaNTD - beta interaction site [polypeptide binding]; other site 937773005844 alphaNTD - beta' interaction site [polypeptide binding]; other site 937773005845 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 937773005846 30S ribosomal protein S11; Validated; Region: PRK05309 937773005847 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 937773005848 30S ribosomal protein S13; Region: bact_S13; TIGR03631 937773005849 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 937773005850 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 937773005851 rRNA binding site [nucleotide binding]; other site 937773005852 predicted 30S ribosome binding site; other site 937773005853 adenylate kinase; Reviewed; Region: adk; PRK00279 937773005854 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 937773005855 AMP-binding site [chemical binding]; other site 937773005856 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 937773005857 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 937773005858 SecY translocase; Region: SecY; pfam00344 937773005859 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 937773005860 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 937773005861 23S rRNA binding site [nucleotide binding]; other site 937773005862 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 937773005863 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 937773005864 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 937773005865 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 937773005866 5S rRNA interface [nucleotide binding]; other site 937773005867 L27 interface [polypeptide binding]; other site 937773005868 23S rRNA interface [nucleotide binding]; other site 937773005869 L5 interface [polypeptide binding]; other site 937773005870 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 937773005871 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 937773005872 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 937773005873 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 937773005874 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 937773005875 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 937773005876 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 937773005877 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 937773005878 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 937773005879 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 937773005880 RNA binding site [nucleotide binding]; other site 937773005881 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 937773005882 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 937773005883 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 937773005884 23S rRNA interface [nucleotide binding]; other site 937773005885 putative translocon interaction site; other site 937773005886 signal recognition particle (SRP54) interaction site; other site 937773005887 L23 interface [polypeptide binding]; other site 937773005888 trigger factor interaction site; other site 937773005889 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 937773005890 23S rRNA interface [nucleotide binding]; other site 937773005891 5S rRNA interface [nucleotide binding]; other site 937773005892 putative antibiotic binding site [chemical binding]; other site 937773005893 L25 interface [polypeptide binding]; other site 937773005894 L27 interface [polypeptide binding]; other site 937773005895 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 937773005896 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 937773005897 G-X-X-G motif; other site 937773005898 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 937773005899 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 937773005900 putative translocon binding site; other site 937773005901 protein-rRNA interface [nucleotide binding]; other site 937773005902 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 937773005903 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 937773005904 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 937773005905 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 937773005906 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 937773005907 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 937773005908 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 937773005909 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 937773005910 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 937773005911 DNA topoisomerase III; Provisional; Region: PRK07726 937773005912 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 937773005913 active site 937773005914 putative interdomain interaction site [polypeptide binding]; other site 937773005915 putative metal-binding site [ion binding]; other site 937773005916 putative nucleotide binding site [chemical binding]; other site 937773005917 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 937773005918 domain I; other site 937773005919 DNA binding groove [nucleotide binding] 937773005920 phosphate binding site [ion binding]; other site 937773005921 domain II; other site 937773005922 domain III; other site 937773005923 nucleotide binding site [chemical binding]; other site 937773005924 catalytic site [active] 937773005925 domain IV; other site 937773005926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773005927 Coenzyme A binding pocket [chemical binding]; other site 937773005928 Predicted permeases [General function prediction only]; Region: COG0679 937773005929 transaminase; Reviewed; Region: PRK08068 937773005930 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773005931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773005932 homodimer interface [polypeptide binding]; other site 937773005933 catalytic residue [active] 937773005934 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 937773005935 Protein export membrane protein; Region: SecD_SecF; cl14618 937773005936 Protein export membrane protein; Region: SecD_SecF; cl14618 937773005937 FemAB family; Region: FemAB; pfam02388 937773005938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 937773005939 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 937773005940 MarR family; Region: MarR_2; pfam12802 937773005941 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 937773005942 generic binding surface II; other site 937773005943 generic binding surface I; other site 937773005944 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 937773005945 putative catalytic site [active] 937773005946 putative metal binding site [ion binding]; other site 937773005947 putative phosphate binding site [ion binding]; other site 937773005948 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 937773005949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773005950 FeS/SAM binding site; other site 937773005951 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 937773005952 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 937773005953 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 937773005954 GTP binding site; other site 937773005955 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 937773005956 MoaE interaction surface [polypeptide binding]; other site 937773005957 MoeB interaction surface [polypeptide binding]; other site 937773005958 thiocarboxylated glycine; other site 937773005959 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 937773005960 MoaE homodimer interface [polypeptide binding]; other site 937773005961 MoaD interaction [polypeptide binding]; other site 937773005962 active site residues [active] 937773005963 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 937773005964 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 937773005965 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 937773005966 dimer interface [polypeptide binding]; other site 937773005967 putative functional site; other site 937773005968 putative MPT binding site; other site 937773005969 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 937773005970 trimer interface [polypeptide binding]; other site 937773005971 dimer interface [polypeptide binding]; other site 937773005972 putative active site [active] 937773005973 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 937773005974 MPT binding site; other site 937773005975 trimer interface [polypeptide binding]; other site 937773005976 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 937773005977 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 937773005978 ATP binding site [chemical binding]; other site 937773005979 substrate interface [chemical binding]; other site 937773005980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773005981 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 937773005982 Walker A/P-loop; other site 937773005983 ATP binding site [chemical binding]; other site 937773005984 Q-loop/lid; other site 937773005985 ABC transporter signature motif; other site 937773005986 Walker B; other site 937773005987 D-loop; other site 937773005988 H-loop/switch region; other site 937773005989 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 937773005990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773005991 dimer interface [polypeptide binding]; other site 937773005992 conserved gate region; other site 937773005993 putative PBP binding loops; other site 937773005994 ABC-ATPase subunit interface; other site 937773005995 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 937773005996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 937773005997 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 937773005998 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 937773005999 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 937773006000 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 937773006001 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 937773006002 NAD binding site [chemical binding]; other site 937773006003 homodimer interface [polypeptide binding]; other site 937773006004 active site 937773006005 substrate binding site [chemical binding]; other site 937773006006 galactokinase; Provisional; Region: PRK05322 937773006007 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 937773006008 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 937773006009 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 937773006010 Transcriptional regulators [Transcription]; Region: PurR; COG1609 937773006011 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773006012 DNA binding site [nucleotide binding] 937773006013 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 937773006014 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 937773006015 BioY family; Region: BioY; pfam02632 937773006016 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 937773006017 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 937773006018 nucleotide binding site [chemical binding]; other site 937773006019 Transcriptional regulators [Transcription]; Region: FadR; COG2186 937773006020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773006021 DNA-binding site [nucleotide binding]; DNA binding site 937773006022 FCD domain; Region: FCD; pfam07729 937773006023 N-acetylneuraminate lyase; Provisional; Region: PRK04147 937773006024 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 937773006025 inhibitor site; inhibition site 937773006026 active site 937773006027 dimer interface [polypeptide binding]; other site 937773006028 catalytic residue [active] 937773006029 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 937773006030 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 937773006031 Na binding site [ion binding]; other site 937773006032 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 937773006033 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 937773006034 intersubunit interface [polypeptide binding]; other site 937773006035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 937773006036 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 937773006037 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 937773006038 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 937773006039 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 937773006040 DoxX-like family; Region: DoxX_2; pfam13564 937773006041 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 937773006042 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 937773006043 Surface antigen [General function prediction only]; Region: COG3942 937773006044 CHAP domain; Region: CHAP; pfam05257 937773006045 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 937773006046 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 937773006047 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 937773006048 Surface antigen [General function prediction only]; Region: COG3942 937773006049 CHAP domain; Region: CHAP; pfam05257 937773006050 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 937773006051 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 937773006052 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 937773006053 putative ligand binding site [chemical binding]; other site 937773006054 putative NAD binding site [chemical binding]; other site 937773006055 catalytic site [active] 937773006056 hypothetical protein; Provisional; Region: PRK06753 937773006057 hypothetical protein; Provisional; Region: PRK07236 937773006058 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 937773006059 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 937773006060 Uncharacterized conserved protein [Function unknown]; Region: COG2427 937773006061 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 937773006062 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 937773006063 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 937773006064 4Fe-4S binding domain; Region: Fer4_6; pfam12837 937773006065 4Fe-4S binding domain; Region: Fer4; pfam00037 937773006066 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 937773006067 [4Fe-4S] binding site [ion binding]; other site 937773006068 molybdopterin cofactor binding site; other site 937773006069 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 937773006070 molybdopterin cofactor binding site; other site 937773006071 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 937773006072 putative substrate binding pocket [chemical binding]; other site 937773006073 AC domain interface; other site 937773006074 catalytic triad [active] 937773006075 AB domain interface; other site 937773006076 interchain disulfide; other site 937773006077 Predicted membrane protein [Function unknown]; Region: COG3817 937773006078 Protein of unknown function (DUF979); Region: DUF979; pfam06166 937773006079 Protein of unknown function (DUF969); Region: DUF969; pfam06149 937773006080 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 937773006081 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 937773006082 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 937773006083 active site 937773006084 Predicted transcriptional regulator [Transcription]; Region: COG2378 937773006085 HTH domain; Region: HTH_11; pfam08279 937773006086 CAAX protease self-immunity; Region: Abi; pfam02517 937773006087 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 937773006088 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 937773006089 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 937773006090 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 937773006091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773006092 motif II; other site 937773006093 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 937773006094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 937773006095 Zn binding site [ion binding]; other site 937773006096 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773006097 active site 937773006098 metal binding site [ion binding]; metal-binding site 937773006099 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 937773006100 Sodium Bile acid symporter family; Region: SBF; pfam01758 937773006101 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 937773006102 putative hydrophobic ligand binding site [chemical binding]; other site 937773006103 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 937773006104 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 937773006105 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 937773006106 metal binding site [ion binding]; metal-binding site 937773006107 dimer interface [polypeptide binding]; other site 937773006108 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 937773006109 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 937773006110 Sulfate transporter family; Region: Sulfate_transp; pfam00916 937773006111 imidazolonepropionase; Validated; Region: PRK09356 937773006112 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 937773006113 active site 937773006114 urocanate hydratase; Provisional; Region: PRK05414 937773006115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 937773006116 Nucleoside recognition; Region: Gate; pfam07670 937773006117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 937773006118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 937773006119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 937773006120 dimerization interface [polypeptide binding]; other site 937773006121 CAAX protease self-immunity; Region: Abi; pfam02517 937773006122 formimidoylglutamase; Provisional; Region: PRK13775 937773006123 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 937773006124 putative active site [active] 937773006125 putative metal binding site [ion binding]; other site 937773006126 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 937773006127 tetramer (dimer of dimers) interface [polypeptide binding]; other site 937773006128 active site 937773006129 dimer interface [polypeptide binding]; other site 937773006130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 937773006131 MOSC domain; Region: MOSC; pfam03473 937773006132 3-alpha domain; Region: 3-alpha; pfam03475 937773006133 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 937773006134 active site 937773006135 catalytic residues [active] 937773006136 hypothetical protein; Provisional; Region: PRK02237 937773006137 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 937773006138 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 937773006139 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 937773006140 Walker A/P-loop; other site 937773006141 ATP binding site [chemical binding]; other site 937773006142 Q-loop/lid; other site 937773006143 ABC transporter signature motif; other site 937773006144 Walker B; other site 937773006145 D-loop; other site 937773006146 H-loop/switch region; other site 937773006147 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 937773006148 Predicted membrane protein [Function unknown]; Region: COG3152 937773006149 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 937773006150 active site 937773006151 DNA binding site [nucleotide binding] 937773006152 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 937773006153 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 937773006154 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 937773006155 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 937773006156 Predicted transcriptional regulators [Transcription]; Region: COG1695 937773006157 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 937773006158 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 937773006159 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 937773006160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 937773006161 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 937773006162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 937773006163 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 937773006164 Transposase, Mutator family; Region: Transposase_mut; pfam00872 937773006165 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 937773006166 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 937773006167 putative active site [active] 937773006168 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 937773006169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773006170 Walker A/P-loop; other site 937773006171 ATP binding site [chemical binding]; other site 937773006172 Q-loop/lid; other site 937773006173 ABC transporter signature motif; other site 937773006174 Walker B; other site 937773006175 D-loop; other site 937773006176 H-loop/switch region; other site 937773006177 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 937773006178 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 937773006179 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 937773006180 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 937773006181 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 937773006182 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 937773006183 homotetramer interface [polypeptide binding]; other site 937773006184 FMN binding site [chemical binding]; other site 937773006185 homodimer contacts [polypeptide binding]; other site 937773006186 putative active site [active] 937773006187 putative substrate binding site [chemical binding]; other site 937773006188 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 937773006189 active site 937773006190 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 937773006191 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 937773006192 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 937773006193 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 937773006194 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 937773006195 catalytic residues [active] 937773006196 Putative transcription activator [Transcription]; Region: TenA; COG0819 937773006197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 937773006198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 937773006199 Predicted membrane protein [Function unknown]; Region: COG4640 937773006200 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773006201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 937773006202 putative DNA binding site [nucleotide binding]; other site 937773006203 putative Zn2+ binding site [ion binding]; other site 937773006204 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 937773006205 putative active site [active] 937773006206 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 937773006207 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 937773006208 Walker A/P-loop; other site 937773006209 ATP binding site [chemical binding]; other site 937773006210 Q-loop/lid; other site 937773006211 ABC transporter signature motif; other site 937773006212 Walker B; other site 937773006213 D-loop; other site 937773006214 H-loop/switch region; other site 937773006215 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 937773006216 FtsX-like permease family; Region: FtsX; pfam02687 937773006217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773006218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006219 active site 937773006220 phosphorylation site [posttranslational modification] 937773006221 intermolecular recognition site; other site 937773006222 dimerization interface [polypeptide binding]; other site 937773006223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773006224 DNA binding site [nucleotide binding] 937773006225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 937773006226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 937773006227 dimerization interface [polypeptide binding]; other site 937773006228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773006229 ATP binding site [chemical binding]; other site 937773006230 Mg2+ binding site [ion binding]; other site 937773006231 G-X-G motif; other site 937773006232 malate:quinone oxidoreductase; Validated; Region: PRK05257 937773006233 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 937773006234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 937773006235 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 937773006236 putative ADP-binding pocket [chemical binding]; other site 937773006237 L-lactate permease; Region: Lactate_perm; cl00701 937773006238 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 937773006239 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 937773006240 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 937773006241 folate binding site [chemical binding]; other site 937773006242 NADP+ binding site [chemical binding]; other site 937773006243 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 937773006244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773006245 Coenzyme A binding pocket [chemical binding]; other site 937773006246 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 937773006247 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 937773006248 NAD(P) binding site [chemical binding]; other site 937773006249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006250 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 937773006251 putative substrate translocation pore; other site 937773006252 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 937773006253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 937773006254 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 937773006255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773006256 Coenzyme A binding pocket [chemical binding]; other site 937773006257 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 937773006258 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 937773006259 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 937773006260 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 937773006261 PhoU domain; Region: PhoU; pfam01895 937773006262 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 937773006263 MarR family; Region: MarR_2; pfam12802 937773006264 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 937773006265 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 937773006266 Cl binding site [ion binding]; other site 937773006267 oligomer interface [polypeptide binding]; other site 937773006268 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 937773006269 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773006270 active site turn [active] 937773006271 phosphorylation site [posttranslational modification] 937773006272 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 937773006273 Helix-turn-helix domain; Region: HTH_18; pfam12833 937773006274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 937773006275 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 937773006276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006277 putative substrate translocation pore; other site 937773006278 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 937773006279 EamA-like transporter family; Region: EamA; pfam00892 937773006280 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 937773006281 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 937773006282 oligomer interface [polypeptide binding]; other site 937773006283 active site 937773006284 metal binding site [ion binding]; metal-binding site 937773006285 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 937773006286 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 937773006287 NAD(P) binding site [chemical binding]; other site 937773006288 LDH/MDH dimer interface [polypeptide binding]; other site 937773006289 substrate binding site [chemical binding]; other site 937773006290 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 937773006291 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 937773006292 putative metal binding site [ion binding]; other site 937773006293 putative dimer interface [polypeptide binding]; other site 937773006294 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 937773006295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006296 putative substrate translocation pore; other site 937773006297 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 937773006298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006299 active site 937773006300 phosphorylation site [posttranslational modification] 937773006301 intermolecular recognition site; other site 937773006302 dimerization interface [polypeptide binding]; other site 937773006303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 937773006304 DNA binding residues [nucleotide binding] 937773006305 dimerization interface [polypeptide binding]; other site 937773006306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 937773006307 Histidine kinase; Region: HisKA_3; pfam07730 937773006308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773006309 ATP binding site [chemical binding]; other site 937773006310 Mg2+ binding site [ion binding]; other site 937773006311 G-X-G motif; other site 937773006312 GAF domain; Region: GAF; pfam01590 937773006313 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 937773006314 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 937773006315 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 937773006316 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 937773006317 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 937773006318 [4Fe-4S] binding site [ion binding]; other site 937773006319 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 937773006320 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 937773006321 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 937773006322 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 937773006323 molybdopterin cofactor binding site; other site 937773006324 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 937773006325 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 937773006326 active site 937773006327 metal binding site [ion binding]; metal-binding site 937773006328 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 937773006329 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 937773006330 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 937773006331 active site 937773006332 SAM binding site [chemical binding]; other site 937773006333 homodimer interface [polypeptide binding]; other site 937773006334 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 937773006335 [2Fe-2S] cluster binding site [ion binding]; other site 937773006336 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 937773006337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 937773006338 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773006339 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 937773006340 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 937773006341 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 937773006342 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 937773006343 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 937773006344 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 937773006345 putative active site [active] 937773006346 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 937773006347 active site 937773006348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 937773006349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 937773006350 Coenzyme A binding pocket [chemical binding]; other site 937773006351 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 937773006352 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 937773006353 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 937773006354 transmembrane helices; other site 937773006355 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 937773006356 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 937773006357 Replication initiation factor; Region: Rep_trans; pfam02486 937773006358 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 937773006359 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 937773006360 NAD(P) binding site [chemical binding]; other site 937773006361 catalytic residues [active] 937773006362 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 937773006363 putative phosphoesterase; Region: acc_ester; TIGR03729 937773006364 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 937773006365 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 937773006366 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 937773006367 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 937773006368 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 937773006369 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 937773006370 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 937773006371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773006372 dimer interface [polypeptide binding]; other site 937773006373 conserved gate region; other site 937773006374 putative PBP binding loops; other site 937773006375 ABC-ATPase subunit interface; other site 937773006376 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 937773006377 NADH(P)-binding; Region: NAD_binding_10; pfam13460 937773006378 NAD(P) binding site [chemical binding]; other site 937773006379 putative active site [active] 937773006380 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 937773006381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 937773006382 FeS/SAM binding site; other site 937773006383 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 937773006384 Pyruvate formate lyase 1; Region: PFL1; cd01678 937773006385 coenzyme A binding site [chemical binding]; other site 937773006386 active site 937773006387 catalytic residues [active] 937773006388 glycine loop; other site 937773006389 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 937773006390 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 937773006391 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 937773006392 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 937773006393 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 937773006394 NAD binding site [chemical binding]; other site 937773006395 Phe binding site; other site 937773006396 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 937773006397 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 937773006398 Hemerythrin-like domain; Region: Hr-like; cd12108 937773006399 Fe binding site [ion binding]; other site 937773006400 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 937773006401 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 937773006402 active site 937773006403 catalytic site [active] 937773006404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006405 D-galactonate transporter; Region: 2A0114; TIGR00893 937773006406 putative substrate translocation pore; other site 937773006407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773006409 putative substrate translocation pore; other site 937773006410 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 937773006411 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 937773006412 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 937773006413 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 937773006414 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 937773006415 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 937773006416 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 937773006417 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 937773006418 DNA binding residues [nucleotide binding] 937773006419 dimer interface [polypeptide binding]; other site 937773006420 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 937773006421 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 937773006422 Int/Topo IB signature motif; other site 937773006423 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 937773006424 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 937773006425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 937773006426 DNA binding residues [nucleotide binding] 937773006427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006428 non-specific DNA binding site [nucleotide binding]; other site 937773006429 salt bridge; other site 937773006430 sequence-specific DNA binding site [nucleotide binding]; other site 937773006431 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 937773006432 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 937773006433 G1 box; other site 937773006434 putative GEF interaction site [polypeptide binding]; other site 937773006435 GTP/Mg2+ binding site [chemical binding]; other site 937773006436 Switch I region; other site 937773006437 G2 box; other site 937773006438 G3 box; other site 937773006439 Switch II region; other site 937773006440 G4 box; other site 937773006441 G5 box; other site 937773006442 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 937773006443 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 937773006444 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 937773006445 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 937773006446 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 937773006447 N-acetyl-D-glucosamine binding site [chemical binding]; other site 937773006448 catalytic residue [active] 937773006449 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 937773006450 NlpC/P60 family; Region: NLPC_P60; pfam00877 937773006451 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 937773006452 Haemolysin-III related; Region: HlyIII; cl03831 937773006453 AAA-like domain; Region: AAA_10; pfam12846 937773006454 TcpE family; Region: TcpE; pfam12648 937773006455 Antirestriction protein (ArdA); Region: ArdA; pfam07275 937773006456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006457 non-specific DNA binding site [nucleotide binding]; other site 937773006458 salt bridge; other site 937773006459 sequence-specific DNA binding site [nucleotide binding]; other site 937773006460 Replication initiation factor; Region: Rep_trans; pfam02486 937773006461 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 937773006462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773006463 Walker A motif; other site 937773006464 ATP binding site [chemical binding]; other site 937773006465 Walker B motif; other site 937773006466 arginine finger; other site 937773006467 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 937773006468 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 937773006469 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 937773006470 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 937773006471 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 937773006472 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 937773006473 Walker A/P-loop; other site 937773006474 ATP binding site [chemical binding]; other site 937773006475 Q-loop/lid; other site 937773006476 ABC transporter signature motif; other site 937773006477 Walker B; other site 937773006478 D-loop; other site 937773006479 H-loop/switch region; other site 937773006480 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 937773006481 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 937773006482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773006483 Walker A/P-loop; other site 937773006484 ATP binding site [chemical binding]; other site 937773006485 Q-loop/lid; other site 937773006486 ABC transporter signature motif; other site 937773006487 Walker B; other site 937773006488 D-loop; other site 937773006489 H-loop/switch region; other site 937773006490 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 937773006491 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 937773006492 Cysteine-rich domain; Region: CCG; pfam02754 937773006493 Cysteine-rich domain; Region: CCG; pfam02754 937773006494 FAD binding domain; Region: FAD_binding_4; pfam01565 937773006495 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 937773006496 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 937773006497 active site 937773006498 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 937773006499 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 937773006500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 937773006501 motif II; other site 937773006502 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 937773006503 substrate binding site [chemical binding]; other site 937773006504 active site 937773006505 catalytic residues [active] 937773006506 heterodimer interface [polypeptide binding]; other site 937773006507 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 937773006508 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 937773006509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773006510 catalytic residue [active] 937773006511 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 937773006512 active site 937773006513 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 937773006514 active site 937773006515 ribulose/triose binding site [chemical binding]; other site 937773006516 phosphate binding site [ion binding]; other site 937773006517 substrate (anthranilate) binding pocket [chemical binding]; other site 937773006518 product (indole) binding pocket [chemical binding]; other site 937773006519 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 937773006520 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 937773006521 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 937773006522 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 937773006523 Glutamine amidotransferase class-I; Region: GATase; pfam00117 937773006524 glutamine binding [chemical binding]; other site 937773006525 catalytic triad [active] 937773006526 anthranilate synthase component I; Provisional; Region: PRK13567 937773006527 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 937773006528 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 937773006529 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 937773006530 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 937773006531 dimer interface [polypeptide binding]; other site 937773006532 PYR/PP interface [polypeptide binding]; other site 937773006533 TPP binding site [chemical binding]; other site 937773006534 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 937773006535 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 937773006536 TPP-binding site [chemical binding]; other site 937773006537 dimer interface [polypeptide binding]; other site 937773006538 Predicted membrane protein [Function unknown]; Region: COG2855 937773006539 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 937773006540 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 937773006541 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 937773006542 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 937773006543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 937773006544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 937773006545 oxidoreductase; Provisional; Region: PRK07985 937773006546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 937773006547 NAD(P) binding site [chemical binding]; other site 937773006548 active site 937773006549 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 937773006550 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 937773006551 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 937773006552 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 937773006553 active site 937773006554 Zn binding site [ion binding]; other site 937773006555 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 937773006556 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 937773006557 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 937773006558 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 937773006559 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 937773006560 Peptidase family M23; Region: Peptidase_M23; pfam01551 937773006561 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 937773006562 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 937773006563 synthetase active site [active] 937773006564 NTP binding site [chemical binding]; other site 937773006565 metal binding site [ion binding]; metal-binding site 937773006566 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 937773006567 dimer interface [polypeptide binding]; other site 937773006568 FMN binding site [chemical binding]; other site 937773006569 Transcriptional regulators [Transcription]; Region: MarR; COG1846 937773006570 MarR family; Region: MarR; pfam01047 937773006571 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 937773006572 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 937773006573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 937773006574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 937773006575 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 937773006576 putative dimerization interface [polypeptide binding]; other site 937773006577 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 937773006578 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 937773006579 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 937773006580 Ligand Binding Site [chemical binding]; other site 937773006581 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 937773006582 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 937773006583 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 937773006584 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 937773006585 trimer interface [polypeptide binding]; other site 937773006586 active site 937773006587 urease subunit alpha; Reviewed; Region: ureC; PRK13207 937773006588 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 937773006589 subunit interactions [polypeptide binding]; other site 937773006590 active site 937773006591 flap region; other site 937773006592 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 937773006593 gamma-beta subunit interface [polypeptide binding]; other site 937773006594 alpha-beta subunit interface [polypeptide binding]; other site 937773006595 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 937773006596 alpha-gamma subunit interface [polypeptide binding]; other site 937773006597 beta-gamma subunit interface [polypeptide binding]; other site 937773006598 Urea transporter; Region: UT; cl01829 937773006599 Urea transporter; Region: UT; cl01829 937773006600 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 937773006601 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 937773006602 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 937773006603 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 937773006604 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 937773006605 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 937773006606 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 937773006607 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 937773006608 FtsX-like permease family; Region: FtsX; pfam02687 937773006609 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 937773006610 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 937773006611 Walker A/P-loop; other site 937773006612 ATP binding site [chemical binding]; other site 937773006613 Q-loop/lid; other site 937773006614 ABC transporter signature motif; other site 937773006615 Walker B; other site 937773006616 D-loop; other site 937773006617 H-loop/switch region; other site 937773006618 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 937773006619 HlyD family secretion protein; Region: HlyD_3; pfam13437 937773006620 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 937773006621 Phosphotransferase enzyme family; Region: APH; pfam01636 937773006622 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 937773006623 active site 937773006624 ATP binding site [chemical binding]; other site 937773006625 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 937773006626 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 937773006627 dimer interface [polypeptide binding]; other site 937773006628 FMN binding site [chemical binding]; other site 937773006629 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 937773006630 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 937773006631 active site 937773006632 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 937773006633 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 937773006634 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 937773006635 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 937773006636 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 937773006637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 937773006638 active site 937773006639 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 937773006640 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 937773006641 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 937773006642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 937773006643 Walker A/P-loop; other site 937773006644 ATP binding site [chemical binding]; other site 937773006645 Q-loop/lid; other site 937773006646 ABC transporter signature motif; other site 937773006647 Walker B; other site 937773006648 D-loop; other site 937773006649 H-loop/switch region; other site 937773006650 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 937773006651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 937773006652 Walker A/P-loop; other site 937773006653 ATP binding site [chemical binding]; other site 937773006654 Q-loop/lid; other site 937773006655 ABC transporter signature motif; other site 937773006656 Walker B; other site 937773006657 D-loop; other site 937773006658 H-loop/switch region; other site 937773006659 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 937773006660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773006661 dimer interface [polypeptide binding]; other site 937773006662 conserved gate region; other site 937773006663 putative PBP binding loops; other site 937773006664 ABC-ATPase subunit interface; other site 937773006665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 937773006666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773006667 dimer interface [polypeptide binding]; other site 937773006668 conserved gate region; other site 937773006669 putative PBP binding loops; other site 937773006670 ABC-ATPase subunit interface; other site 937773006671 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 937773006672 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 937773006673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 937773006674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 937773006675 S-adenosylmethionine binding site [chemical binding]; other site 937773006676 Predicted membrane protein [Function unknown]; Region: COG1511 937773006677 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 937773006678 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 937773006679 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 937773006680 CHAP domain; Region: CHAP; pfam05257 937773006681 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 937773006682 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 937773006683 active site 937773006684 P-loop; other site 937773006685 phosphorylation site [posttranslational modification] 937773006686 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 937773006687 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773006688 active site 937773006689 phosphorylation site [posttranslational modification] 937773006690 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 937773006691 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 937773006692 DNA binding residues [nucleotide binding] 937773006693 dimer interface [polypeptide binding]; other site 937773006694 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 937773006695 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 937773006696 succinic semialdehyde dehydrogenase; Region: PLN02278 937773006697 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 937773006698 tetramerization interface [polypeptide binding]; other site 937773006699 NAD(P) binding site [chemical binding]; other site 937773006700 catalytic residues [active] 937773006701 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 937773006702 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 937773006703 PhnA protein; Region: PhnA; pfam03831 937773006704 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 937773006705 DAK2 domain; Region: Dak2; cl03685 937773006706 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 937773006707 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 937773006708 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 937773006709 antiholin-like protein LrgB; Provisional; Region: PRK04288 937773006710 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 937773006711 two-component response regulator; Provisional; Region: PRK14084 937773006712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006713 active site 937773006714 phosphorylation site [posttranslational modification] 937773006715 intermolecular recognition site; other site 937773006716 dimerization interface [polypeptide binding]; other site 937773006717 LytTr DNA-binding domain; Region: LytTR; pfam04397 937773006718 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 937773006719 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 937773006720 GAF domain; Region: GAF_3; pfam13492 937773006721 Histidine kinase; Region: His_kinase; pfam06580 937773006722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773006723 ATP binding site [chemical binding]; other site 937773006724 Mg2+ binding site [ion binding]; other site 937773006725 G-X-G motif; other site 937773006726 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 937773006727 Rib/alpha-like repeat; Region: Rib; cl07159 937773006728 phosphopentomutase; Provisional; Region: PRK05362 937773006729 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 937773006730 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 937773006731 intersubunit interface [polypeptide binding]; other site 937773006732 active site 937773006733 catalytic residue [active] 937773006734 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 937773006735 ATP phosphoribosyltransferase; Region: HisG; cl15266 937773006736 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 937773006737 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 937773006738 histidinol dehydrogenase; Region: hisD; TIGR00069 937773006739 NAD binding site [chemical binding]; other site 937773006740 dimerization interface [polypeptide binding]; other site 937773006741 product binding site; other site 937773006742 substrate binding site [chemical binding]; other site 937773006743 zinc binding site [ion binding]; other site 937773006744 catalytic residues [active] 937773006745 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 937773006746 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773006747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773006748 homodimer interface [polypeptide binding]; other site 937773006749 catalytic residue [active] 937773006750 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 937773006751 putative active site pocket [active] 937773006752 4-fold oligomerization interface [polypeptide binding]; other site 937773006753 metal binding residues [ion binding]; metal-binding site 937773006754 3-fold/trimer interface [polypeptide binding]; other site 937773006755 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 937773006756 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 937773006757 putative active site [active] 937773006758 oxyanion strand; other site 937773006759 catalytic triad [active] 937773006760 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 937773006761 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 937773006762 catalytic residues [active] 937773006763 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 937773006764 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 937773006765 substrate binding site [chemical binding]; other site 937773006766 glutamase interaction surface [polypeptide binding]; other site 937773006767 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 937773006768 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 937773006769 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 937773006770 metal binding site [ion binding]; metal-binding site 937773006771 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 937773006772 EamA-like transporter family; Region: EamA; pfam00892 937773006773 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773006774 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773006775 ornithine carbamoyltransferase; Validated; Region: PRK02102 937773006776 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 937773006777 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 937773006778 choline dehydrogenase; Validated; Region: PRK02106 937773006779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 937773006780 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 937773006781 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 937773006782 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 937773006783 tetramerization interface [polypeptide binding]; other site 937773006784 NAD(P) binding site [chemical binding]; other site 937773006785 catalytic residues [active] 937773006786 Predicted transcriptional regulators [Transcription]; Region: COG1510 937773006787 BCCT family transporter; Region: BCCT; pfam02028 937773006788 manganese transport protein MntH; Reviewed; Region: PRK00701 937773006789 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 937773006790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006791 non-specific DNA binding site [nucleotide binding]; other site 937773006792 salt bridge; other site 937773006793 sequence-specific DNA binding site [nucleotide binding]; other site 937773006794 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 937773006795 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 937773006796 cofactor binding site; other site 937773006797 DNA binding site [nucleotide binding] 937773006798 substrate interaction site [chemical binding]; other site 937773006799 EcoRII C terminal; Region: EcoRII-C; pfam09019 937773006800 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 937773006801 dimer interface [polypeptide binding]; other site 937773006802 Alkaline phosphatase homologues; Region: alkPPc; smart00098 937773006803 active site 937773006804 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 937773006805 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 937773006806 Catalytic site [active] 937773006807 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 937773006808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773006809 non-specific DNA binding site [nucleotide binding]; other site 937773006810 salt bridge; other site 937773006811 sequence-specific DNA binding site [nucleotide binding]; other site 937773006812 Cupin domain; Region: Cupin_2; pfam07883 937773006813 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 937773006814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006815 putative substrate translocation pore; other site 937773006816 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 937773006817 ThiC-associated domain; Region: ThiC-associated; pfam13667 937773006818 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 937773006819 ThiC family; Region: ThiC; pfam01964 937773006820 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 937773006821 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 937773006822 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 937773006823 putative active site [active] 937773006824 catalytic site [active] 937773006825 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 937773006826 putative active site [active] 937773006827 catalytic site [active] 937773006828 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 937773006829 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 937773006830 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 937773006831 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 937773006832 active site 937773006833 dimerization interface [polypeptide binding]; other site 937773006834 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 937773006835 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 937773006836 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 937773006837 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 937773006838 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 937773006839 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 937773006840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773006843 putative substrate translocation pore; other site 937773006844 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 937773006845 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 937773006846 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 937773006847 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 937773006848 active site 937773006849 tetramer interface; other site 937773006850 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 937773006851 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 937773006852 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 937773006853 Histidine kinase; Region: His_kinase; pfam06580 937773006854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773006855 ATP binding site [chemical binding]; other site 937773006856 Mg2+ binding site [ion binding]; other site 937773006857 G-X-G motif; other site 937773006858 Response regulator receiver domain; Region: Response_reg; pfam00072 937773006859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006860 active site 937773006861 phosphorylation site [posttranslational modification] 937773006862 intermolecular recognition site; other site 937773006863 dimerization interface [polypeptide binding]; other site 937773006864 Helix-turn-helix domain; Region: HTH_18; pfam12833 937773006865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 937773006866 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 937773006867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006868 putative substrate translocation pore; other site 937773006869 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 937773006870 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 937773006871 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 937773006872 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 937773006873 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 937773006874 catalytic residue [active] 937773006875 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 937773006876 intersubunit interface [polypeptide binding]; other site 937773006877 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 937773006878 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 937773006879 YodA lipocalin-like domain; Region: YodA; pfam09223 937773006880 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 937773006881 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 937773006882 potential catalytic triad [active] 937773006883 conserved cys residue [active] 937773006884 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 937773006885 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 937773006886 Na binding site [ion binding]; other site 937773006887 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 937773006888 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 937773006889 active site 937773006890 non-prolyl cis peptide bond; other site 937773006891 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 937773006892 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 937773006893 homodimer interface [polypeptide binding]; other site 937773006894 substrate-cofactor binding pocket; other site 937773006895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773006896 catalytic residue [active] 937773006897 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 937773006898 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 937773006899 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 937773006900 Class III ribonucleotide reductase; Region: RNR_III; cd01675 937773006901 effector binding site; other site 937773006902 active site 937773006903 Zn binding site [ion binding]; other site 937773006904 glycine loop; other site 937773006905 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 937773006906 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 937773006907 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773006908 active site 937773006909 phosphorylation site [posttranslational modification] 937773006910 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 937773006911 HTH domain; Region: HTH_11; pfam08279 937773006912 HTH domain; Region: HTH_11; pfam08279 937773006913 PRD domain; Region: PRD; pfam00874 937773006914 PRD domain; Region: PRD; pfam00874 937773006915 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 937773006916 active site 937773006917 P-loop; other site 937773006918 phosphorylation site [posttranslational modification] 937773006919 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 937773006920 active site 937773006921 phosphorylation site [posttranslational modification] 937773006922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 937773006923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 937773006924 dimerization interface [polypeptide binding]; other site 937773006925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773006926 dimer interface [polypeptide binding]; other site 937773006927 phosphorylation site [posttranslational modification] 937773006928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773006929 ATP binding site [chemical binding]; other site 937773006930 Mg2+ binding site [ion binding]; other site 937773006931 G-X-G motif; other site 937773006932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773006933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773006934 active site 937773006935 phosphorylation site [posttranslational modification] 937773006936 intermolecular recognition site; other site 937773006937 dimerization interface [polypeptide binding]; other site 937773006938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773006939 DNA binding site [nucleotide binding] 937773006940 Electron transfer DM13; Region: DM13; pfam10517 937773006941 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 937773006942 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 937773006943 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 937773006944 substrate binding site [chemical binding]; other site 937773006945 dimer interface [polypeptide binding]; other site 937773006946 ATP binding site [chemical binding]; other site 937773006947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 937773006948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773006949 DNA binding site [nucleotide binding] 937773006950 domain linker motif; other site 937773006951 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 937773006952 dimerization interface [polypeptide binding]; other site 937773006953 ligand binding site [chemical binding]; other site 937773006954 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 937773006955 putative catalytic residues [active] 937773006956 AAA domain; Region: AAA_17; pfam13207 937773006957 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 937773006958 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 937773006959 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 937773006960 Walker A/P-loop; other site 937773006961 ATP binding site [chemical binding]; other site 937773006962 Q-loop/lid; other site 937773006963 ABC transporter signature motif; other site 937773006964 Walker B; other site 937773006965 D-loop; other site 937773006966 H-loop/switch region; other site 937773006967 NMT1-like family; Region: NMT1_2; pfam13379 937773006968 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 937773006969 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 937773006970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773006971 dimer interface [polypeptide binding]; other site 937773006972 conserved gate region; other site 937773006973 putative PBP binding loops; other site 937773006974 ABC-ATPase subunit interface; other site 937773006975 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 937773006976 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 937773006977 active site 937773006978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 937773006979 Major Facilitator Superfamily; Region: MFS_1; pfam07690 937773006980 putative substrate translocation pore; other site 937773006981 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 937773006982 Coenzyme A transferase; Region: CoA_trans; smart00882 937773006983 Coenzyme A transferase; Region: CoA_trans; cl17247 937773006984 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 937773006985 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 937773006986 acyl-activating enzyme (AAE) consensus motif; other site 937773006987 AMP binding site [chemical binding]; other site 937773006988 active site 937773006989 CoA binding site [chemical binding]; other site 937773006990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 937773006991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 937773006992 active site 937773006993 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 937773006994 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 937773006995 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 937773006996 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 937773006997 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 937773006998 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 937773006999 substrate binding site [chemical binding]; other site 937773007000 oxyanion hole (OAH) forming residues; other site 937773007001 trimer interface [polypeptide binding]; other site 937773007002 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 937773007003 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 937773007004 dimer interface [polypeptide binding]; other site 937773007005 active site 937773007006 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 937773007007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 937773007008 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 937773007009 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 937773007010 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 937773007011 DEAD/DEAH box helicase; Region: DEAD; pfam00270 937773007012 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 937773007013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 937773007014 nucleotide binding region [chemical binding]; other site 937773007015 ATP-binding site [chemical binding]; other site 937773007016 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 937773007017 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 937773007018 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 937773007019 accessory Sec system translocase SecY2; Region: acc_sec_Y2; TIGR02920 937773007020 SecY translocase; Region: SecY; pfam00344 937773007021 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 937773007022 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 937773007023 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 937773007024 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 937773007025 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 937773007026 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 937773007027 Phospholipid methyltransferase; Region: PEMT; cl17370 937773007028 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 937773007029 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 937773007030 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 937773007031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 937773007032 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 937773007033 Transcriptional regulator; Region: Rrf2; pfam02082 937773007034 Rrf2 family protein; Region: rrf2_super; TIGR00738 937773007035 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 937773007036 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 937773007037 Walker A/P-loop; other site 937773007038 ATP binding site [chemical binding]; other site 937773007039 Q-loop/lid; other site 937773007040 ABC transporter signature motif; other site 937773007041 Walker B; other site 937773007042 D-loop; other site 937773007043 H-loop/switch region; other site 937773007044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 937773007045 FtsX-like permease family; Region: FtsX; pfam02687 937773007046 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 937773007047 Nucleoside recognition; Region: Gate; pfam07670 937773007048 Nucleoside recognition; Region: Gate; pfam07670 937773007049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 937773007050 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 937773007051 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 937773007052 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 937773007053 nucleotide binding site [chemical binding]; other site 937773007054 aminotransferase A; Validated; Region: PRK07683 937773007055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 937773007056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773007057 homodimer interface [polypeptide binding]; other site 937773007058 catalytic residue [active] 937773007059 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 937773007060 Na binding site [ion binding]; other site 937773007061 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 937773007062 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 937773007063 dimerization interface [polypeptide binding]; other site 937773007064 DPS ferroxidase diiron center [ion binding]; other site 937773007065 ion pore; other site 937773007066 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 937773007067 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 937773007068 tetramer interface [polypeptide binding]; other site 937773007069 heme binding pocket [chemical binding]; other site 937773007070 NADPH binding site [chemical binding]; other site 937773007071 metal-dependent hydrolase; Provisional; Region: PRK13291 937773007072 DinB superfamily; Region: DinB_2; pfam12867 937773007073 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 937773007074 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 937773007075 putative dimer interface [polypeptide binding]; other site 937773007076 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 937773007077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773007078 catalytic residue [active] 937773007079 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 937773007080 AsnC family; Region: AsnC_trans_reg; pfam01037 937773007081 CAAX protease self-immunity; Region: Abi; pfam02517 937773007082 azoreductase; Reviewed; Region: PRK00170 937773007083 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 937773007084 Predicted membrane protein [Function unknown]; Region: COG2259 937773007085 Predicted transcriptional regulator [Transcription]; Region: COG2378 937773007086 HTH domain; Region: HTH_11; cl17392 937773007087 WYL domain; Region: WYL; pfam13280 937773007088 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 937773007089 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 937773007090 DXD motif; other site 937773007091 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 937773007092 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 937773007093 Acyltransferase family; Region: Acyl_transf_3; pfam01757 937773007094 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 937773007095 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 937773007096 active site 937773007097 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 937773007098 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 937773007099 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 937773007100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 937773007101 catalytic residue [active] 937773007102 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 937773007103 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 937773007104 inhibitor-cofactor binding pocket; inhibition site 937773007105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773007106 catalytic residue [active] 937773007107 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 937773007108 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 937773007109 L-lactate permease; Region: Lactate_perm; cl00701 937773007110 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 937773007111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773007112 non-specific DNA binding site [nucleotide binding]; other site 937773007113 salt bridge; other site 937773007114 sequence-specific DNA binding site [nucleotide binding]; other site 937773007115 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 937773007116 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 937773007117 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 937773007118 catalytic Zn binding site [ion binding]; other site 937773007119 structural Zn binding site [ion binding]; other site 937773007120 NAD(P) binding site [chemical binding]; other site 937773007121 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 937773007122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 937773007123 non-specific DNA binding site [nucleotide binding]; other site 937773007124 salt bridge; other site 937773007125 sequence-specific DNA binding site [nucleotide binding]; other site 937773007126 Transcriptional regulator [Transcription]; Region: IclR; COG1414 937773007127 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 937773007128 putative DNA binding site [nucleotide binding]; other site 937773007129 putative Zn2+ binding site [ion binding]; other site 937773007130 Bacterial transcriptional regulator; Region: IclR; pfam01614 937773007131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 937773007132 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 937773007133 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 937773007134 NAD(P) binding site [chemical binding]; other site 937773007135 LDH/MDH dimer interface [polypeptide binding]; other site 937773007136 substrate binding site [chemical binding]; other site 937773007137 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 937773007138 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 937773007139 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 937773007140 active site turn [active] 937773007141 phosphorylation site [posttranslational modification] 937773007142 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 937773007143 HPr interaction site; other site 937773007144 glycerol kinase (GK) interaction site [polypeptide binding]; other site 937773007145 active site 937773007146 phosphorylation site [posttranslational modification] 937773007147 Uncharacterized conserved protein [Function unknown]; Region: COG2353 937773007148 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 937773007149 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 937773007150 active site 937773007151 dimer interface [polypeptide binding]; other site 937773007152 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 937773007153 active pocket/dimerization site; other site 937773007154 active site 937773007155 phosphorylation site [posttranslational modification] 937773007156 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 937773007157 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 937773007158 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 937773007159 active site 937773007160 phosphorylation site [posttranslational modification] 937773007161 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 937773007162 Class I aldolases; Region: Aldolase_Class_I; cl17187 937773007163 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 937773007164 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 937773007165 putative substrate binding site [chemical binding]; other site 937773007166 putative ATP binding site [chemical binding]; other site 937773007167 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 937773007168 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 937773007169 dimer interface [polypeptide binding]; other site 937773007170 active site 937773007171 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 937773007172 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 937773007173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773007174 DNA-binding site [nucleotide binding]; DNA binding site 937773007175 UTRA domain; Region: UTRA; pfam07702 937773007176 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 937773007177 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 937773007178 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 937773007179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 937773007180 Walker A/P-loop; other site 937773007181 ATP binding site [chemical binding]; other site 937773007182 Q-loop/lid; other site 937773007183 ABC transporter signature motif; other site 937773007184 Walker B; other site 937773007185 D-loop; other site 937773007186 H-loop/switch region; other site 937773007187 EamA-like transporter family; Region: EamA; pfam00892 937773007188 H+ Antiporter protein; Region: 2A0121; TIGR00900 937773007189 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 937773007190 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 937773007191 Zn binding site [ion binding]; other site 937773007192 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 937773007193 Zn binding site [ion binding]; other site 937773007194 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 937773007195 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 937773007196 TrkA-C domain; Region: TrkA_C; pfam02080 937773007197 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 937773007198 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 937773007199 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 937773007200 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 937773007201 Walker A/P-loop; other site 937773007202 ATP binding site [chemical binding]; other site 937773007203 Q-loop/lid; other site 937773007204 ABC transporter signature motif; other site 937773007205 Walker B; other site 937773007206 D-loop; other site 937773007207 H-loop/switch region; other site 937773007208 TOBE domain; Region: TOBE; pfam03459 937773007209 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 937773007210 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 937773007211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773007212 dimer interface [polypeptide binding]; other site 937773007213 conserved gate region; other site 937773007214 putative PBP binding loops; other site 937773007215 ABC-ATPase subunit interface; other site 937773007216 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 937773007217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 937773007218 dimer interface [polypeptide binding]; other site 937773007219 conserved gate region; other site 937773007220 putative PBP binding loops; other site 937773007221 ABC-ATPase subunit interface; other site 937773007222 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 937773007223 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 937773007224 Ca binding site [ion binding]; other site 937773007225 active site 937773007226 catalytic site [active] 937773007227 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 937773007228 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 937773007229 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 937773007230 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 937773007231 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 937773007232 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 937773007233 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 937773007234 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 937773007235 Transcriptional regulators [Transcription]; Region: PurR; COG1609 937773007236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 937773007237 DNA binding site [nucleotide binding] 937773007238 domain linker motif; other site 937773007239 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 937773007240 dimerization interface [polypeptide binding]; other site 937773007241 ligand binding site [chemical binding]; other site 937773007242 FemAB family; Region: FemAB; pfam02388 937773007243 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 937773007244 Rib/alpha-like repeat; Region: Rib; cl07159 937773007245 Rib/alpha-like repeat; Region: Rib; cl07159 937773007246 Rib/alpha-like repeat; Region: Rib; cl07159 937773007247 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 937773007248 Predicted flavoprotein [General function prediction only]; Region: COG0431 937773007249 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 937773007250 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 937773007251 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 937773007252 amidase catalytic site [active] 937773007253 Zn binding residues [ion binding]; other site 937773007254 substrate binding site [chemical binding]; other site 937773007255 Tic20-like protein; Region: Tic20; pfam09685 937773007256 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 937773007257 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 937773007258 Walker A/P-loop; other site 937773007259 ATP binding site [chemical binding]; other site 937773007260 Q-loop/lid; other site 937773007261 ABC transporter signature motif; other site 937773007262 Walker B; other site 937773007263 D-loop; other site 937773007264 H-loop/switch region; other site 937773007265 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 937773007266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 937773007267 Histidine kinase; Region: HisKA_3; pfam07730 937773007268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773007269 ATP binding site [chemical binding]; other site 937773007270 Mg2+ binding site [ion binding]; other site 937773007271 G-X-G motif; other site 937773007272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 937773007273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773007274 active site 937773007275 phosphorylation site [posttranslational modification] 937773007276 intermolecular recognition site; other site 937773007277 dimerization interface [polypeptide binding]; other site 937773007278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 937773007279 DNA binding residues [nucleotide binding] 937773007280 dimerization interface [polypeptide binding]; other site 937773007281 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 937773007282 Arginine repressor [Transcription]; Region: ArgR; COG1438 937773007283 Winged helix-turn helix; Region: HTH_33; pfam13592 937773007284 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 937773007285 arginine deiminase; Provisional; Region: PRK01388 937773007286 ornithine carbamoyltransferase; Validated; Region: PRK02102 937773007287 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 937773007288 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 937773007289 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 937773007290 Spore germination protein; Region: Spore_permease; cl17796 937773007291 carbamate kinase; Reviewed; Region: PRK12686 937773007292 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 937773007293 putative substrate binding site [chemical binding]; other site 937773007294 nucleotide binding site [chemical binding]; other site 937773007295 nucleotide binding site [chemical binding]; other site 937773007296 homodimer interface [polypeptide binding]; other site 937773007297 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 937773007298 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 937773007299 ligand binding site [chemical binding]; other site 937773007300 flexible hinge region; other site 937773007301 NAD-dependent deacetylase; Provisional; Region: PRK00481 937773007302 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 937773007303 methionine sulfoxide reductase A; Provisional; Region: PRK05528 937773007304 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 937773007305 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 937773007306 metal binding site [ion binding]; metal-binding site 937773007307 dimer interface [polypeptide binding]; other site 937773007308 Fic family protein [Function unknown]; Region: COG3177 937773007309 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 937773007310 Fic/DOC family; Region: Fic; pfam02661 937773007311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 937773007312 putative DNA binding site [nucleotide binding]; other site 937773007313 Predicted membrane protein [Function unknown]; Region: COG4270 937773007314 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 937773007315 Prostaglandin dehydrogenases; Region: PGDH; cd05288 937773007316 NAD(P) binding site [chemical binding]; other site 937773007317 substrate binding site [chemical binding]; other site 937773007318 dimer interface [polypeptide binding]; other site 937773007319 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 937773007320 NADH(P)-binding; Region: NAD_binding_10; pfam13460 937773007321 NAD(P) binding site [chemical binding]; other site 937773007322 putative active site [active] 937773007323 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 937773007324 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 937773007325 potential catalytic triad [active] 937773007326 conserved cys residue [active] 937773007327 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 937773007328 DNA binding residues [nucleotide binding] 937773007329 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 937773007330 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 937773007331 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 937773007332 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 937773007333 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 937773007334 beta-galactosidase; Region: BGL; TIGR03356 937773007335 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 937773007336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 937773007337 DNA-binding site [nucleotide binding]; DNA binding site 937773007338 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 937773007339 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 937773007340 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 937773007341 Soluble P-type ATPase [General function prediction only]; Region: COG4087 937773007342 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 937773007343 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 937773007344 tetramer interface [polypeptide binding]; other site 937773007345 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 937773007346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 937773007347 catalytic residue [active] 937773007348 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 937773007349 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 937773007350 hexamer interface [polypeptide binding]; other site 937773007351 ligand binding site [chemical binding]; other site 937773007352 putative active site [active] 937773007353 NAD(P) binding site [chemical binding]; other site 937773007354 Predicted membrane protein [Function unknown]; Region: COG2311 937773007355 Protein of unknown function (DUF418); Region: DUF418; cl12135 937773007356 Protein of unknown function (DUF418); Region: DUF418; pfam04235 937773007357 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 937773007358 active site 937773007359 NTP binding site [chemical binding]; other site 937773007360 nucleic acid binding site [nucleotide binding]; other site 937773007361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 937773007362 Transposase; Region: DDE_Tnp_ISL3; pfam01610 937773007363 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 937773007364 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 937773007365 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 937773007366 Abortive infection C-terminus; Region: Abi_C; pfam14355 937773007367 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 937773007368 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 937773007369 YycH protein; Region: YycI; cl02015 937773007370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 937773007371 YycH protein; Region: YycH; pfam07435 937773007372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 937773007373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 937773007374 dimerization interface [polypeptide binding]; other site 937773007375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 937773007376 putative active site [active] 937773007377 heme pocket [chemical binding]; other site 937773007378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 937773007379 dimer interface [polypeptide binding]; other site 937773007380 phosphorylation site [posttranslational modification] 937773007381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773007382 ATP binding site [chemical binding]; other site 937773007383 Mg2+ binding site [ion binding]; other site 937773007384 G-X-G motif; other site 937773007385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 937773007386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 937773007387 active site 937773007388 phosphorylation site [posttranslational modification] 937773007389 intermolecular recognition site; other site 937773007390 dimerization interface [polypeptide binding]; other site 937773007391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 937773007392 DNA binding site [nucleotide binding] 937773007393 SdpI/YhfL protein family; Region: SdpI; pfam13630 937773007394 Uncharacterized conserved protein [Function unknown]; Region: COG1284 937773007395 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 937773007396 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 937773007397 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 937773007398 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 937773007399 GDP-binding site [chemical binding]; other site 937773007400 ACT binding site; other site 937773007401 IMP binding site; other site 937773007402 replicative DNA helicase; Region: DnaB; TIGR00665 937773007403 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 937773007404 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 937773007405 Walker A motif; other site 937773007406 ATP binding site [chemical binding]; other site 937773007407 Walker B motif; other site 937773007408 DNA binding loops [nucleotide binding] 937773007409 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 937773007410 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 937773007411 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 937773007412 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 937773007413 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 937773007414 DHH family; Region: DHH; pfam01368 937773007415 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 937773007416 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 937773007417 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 937773007418 Predicted membrane protein [Function unknown]; Region: COG4392 937773007419 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 937773007420 seryl-tRNA synthetase; Provisional; Region: PRK05431 937773007421 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 937773007422 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 937773007423 dimer interface [polypeptide binding]; other site 937773007424 active site 937773007425 motif 1; other site 937773007426 motif 2; other site 937773007427 motif 3; other site 937773007428 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 937773007429 active sites [active] 937773007430 tetramer interface [polypeptide binding]; other site 937773007431 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 937773007432 putative substrate binding site [chemical binding]; other site 937773007433 putative ATP binding site [chemical binding]; other site 937773007434 DNA gyrase subunit A; Validated; Region: PRK05560 937773007435 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 937773007436 CAP-like domain; other site 937773007437 active site 937773007438 primary dimer interface [polypeptide binding]; other site 937773007439 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007440 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007441 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007442 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007443 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007444 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 937773007445 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 937773007446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 937773007447 Mg2+ binding site [ion binding]; other site 937773007448 G-X-G motif; other site 937773007449 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 937773007450 anchoring element; other site 937773007451 dimer interface [polypeptide binding]; other site 937773007452 ATP binding site [chemical binding]; other site 937773007453 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 937773007454 active site 937773007455 putative metal-binding site [ion binding]; other site 937773007456 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 937773007457 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 937773007458 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 937773007459 Thioredoxin; Region: Thioredoxin_4; pfam13462 937773007460 DNA polymerase III subunit beta; Validated; Region: PRK05643 937773007461 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 937773007462 putative DNA binding surface [nucleotide binding]; other site 937773007463 dimer interface [polypeptide binding]; other site 937773007464 beta-clamp/clamp loader binding surface; other site 937773007465 beta-clamp/translesion DNA polymerase binding surface; other site 937773007466 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 937773007467 DnaA N-terminal domain; Region: DnaA_N; pfam11638 937773007468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 937773007469 Walker A motif; other site 937773007470 ATP binding site [chemical binding]; other site 937773007471 Walker B motif; other site 937773007472 arginine finger; other site 937773007473 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 937773007474 DnaA box-binding interface [nucleotide binding]; other site