-- dump date 20140620_080032 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1034809000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1034809000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1034809000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809000004 Walker A motif; other site 1034809000005 ATP binding site [chemical binding]; other site 1034809000006 Walker B motif; other site 1034809000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1034809000008 arginine finger; other site 1034809000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1034809000010 DnaA box-binding interface [nucleotide binding]; other site 1034809000015 DNA polymerase III subunit beta; Validated; Region: PRK05643 1034809000016 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1034809000017 putative DNA binding surface [nucleotide binding]; other site 1034809000018 dimer interface [polypeptide binding]; other site 1034809000019 beta-clamp/clamp loader binding surface; other site 1034809000020 beta-clamp/translesion DNA polymerase binding surface; other site 1034809000024 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1034809000025 recombination protein F; Reviewed; Region: recF; PRK00064 1034809000026 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1034809000027 Walker A/P-loop; other site 1034809000028 ATP binding site [chemical binding]; other site 1034809000029 Q-loop/lid; other site 1034809000030 ABC transporter signature motif; other site 1034809000031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809000032 ABC transporter signature motif; other site 1034809000033 Walker B; other site 1034809000034 D-loop; other site 1034809000035 H-loop/switch region; other site 1034809000040 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1034809000041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809000042 Mg2+ binding site [ion binding]; other site 1034809000043 G-X-G motif; other site 1034809000044 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1034809000045 anchoring element; other site 1034809000046 dimer interface [polypeptide binding]; other site 1034809000047 ATP binding site [chemical binding]; other site 1034809000048 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1034809000049 active site 1034809000050 putative metal-binding site [ion binding]; other site 1034809000051 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1034809000058 DNA gyrase subunit A; Validated; Region: PRK05560 1034809000059 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1034809000060 CAP-like domain; other site 1034809000061 active site 1034809000062 primary dimer interface [polypeptide binding]; other site 1034809000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034809000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034809000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034809000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034809000067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034809000068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034809000076 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1034809000077 putative substrate binding site [chemical binding]; other site 1034809000078 putative ATP binding site [chemical binding]; other site 1034809000081 seryl-tRNA synthetase; Provisional; Region: PRK05431 1034809000082 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1034809000083 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1034809000084 dimer interface [polypeptide binding]; other site 1034809000085 active site 1034809000086 motif 1; other site 1034809000087 motif 2; other site 1034809000088 motif 3; other site 1034809000092 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1034809000094 Predicted membrane protein [Function unknown]; Region: COG4392 1034809000096 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1034809000097 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1034809000098 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1034809000100 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1034809000101 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1034809000102 DHH family; Region: DHH; pfam01368 1034809000103 DHHA1 domain; Region: DHHA1; pfam02272 1034809000106 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1034809000107 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1034809000108 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1034809000112 replicative DNA helicase; Region: DnaB; TIGR00665 1034809000113 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1034809000114 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1034809000115 Walker A motif; other site 1034809000116 ATP binding site [chemical binding]; other site 1034809000117 Walker B motif; other site 1034809000118 DNA binding loops [nucleotide binding] 1034809000122 predicted helix-turn-helix motif with score1081.000,SD 2.87 at aa 346-367 1034809000123 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1034809000124 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1034809000125 GDP-binding site [chemical binding]; other site 1034809000126 ACT binding site; other site 1034809000127 IMP binding site; other site 1034809000132 predicted helix-turn-helix motif with score1007.000,SD 2.62 at aa 287-308 1034809000133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809000134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809000135 active site 1034809000136 phosphorylation site [posttranslational modification] 1034809000137 intermolecular recognition site; other site 1034809000138 dimerization interface [polypeptide binding]; other site 1034809000139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809000140 DNA binding site [nucleotide binding] 1034809000143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1034809000144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034809000145 dimerization interface [polypeptide binding]; other site 1034809000146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1034809000147 putative active site [active] 1034809000148 heme pocket [chemical binding]; other site 1034809000149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809000150 dimer interface [polypeptide binding]; other site 1034809000151 phosphorylation site [posttranslational modification] 1034809000152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809000153 ATP binding site [chemical binding]; other site 1034809000154 Mg2+ binding site [ion binding]; other site 1034809000155 G-X-G motif; other site 1034809000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1034809000161 YycH protein; Region: YycH; pfam07435 1034809000164 YycH protein; Region: YycI; cl02015 1034809000166 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1034809000167 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1034809000168 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 1034809000169 putative active site [active] 1034809000170 putative metal binding site [ion binding]; other site 1034809000172 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 1034809000174 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1034809000175 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1034809000176 DXD motif; other site 1034809000178 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1034809000179 active site 1034809000181 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1034809000183 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1034809000185 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1034809000186 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1034809000187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034809000188 putative DNA binding site [nucleotide binding]; other site 1034809000189 putative Zn2+ binding site [ion binding]; other site 1034809000190 AsnC family; Region: AsnC_trans_reg; pfam01037 1034809000192 predicted helix-turn-helix motif with score1418.000,SD 4.02 at aa 19-40 1034809000195 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1034809000196 putative catalytic site [active] 1034809000197 metal binding site A [ion binding]; metal-binding site 1034809000198 phosphate binding site [ion binding]; other site 1034809000199 metal binding site C [ion binding]; metal-binding site 1034809000200 metal binding site B [ion binding]; metal-binding site 1034809000202 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1034809000203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809000205 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1034809000206 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1034809000207 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1034809000208 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1034809000209 putative NAD(P) binding site [chemical binding]; other site 1034809000210 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1034809000211 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1034809000212 FMN binding site [chemical binding]; other site 1034809000213 active site 1034809000214 catalytic residues [active] 1034809000215 substrate binding site [chemical binding]; other site 1034809000219 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1034809000220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809000221 Walker A/P-loop; other site 1034809000222 ATP binding site [chemical binding]; other site 1034809000223 Q-loop/lid; other site 1034809000224 ABC transporter signature motif; other site 1034809000225 Walker B; other site 1034809000226 D-loop; other site 1034809000227 H-loop/switch region; other site 1034809000232 homology to SagB of S. pyogenes, contains a frameshift after aa 163 of the protein 1034809000233 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 1034809000234 YcaO-like family; Region: YcaO; pfam02624 1034809000235 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1034809000237 CAAX protease self-immunity; Region: Abi; cl00558 1034809000239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034809000240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809000241 phosphorylation site [posttranslational modification] 1034809000242 dimer interface [polypeptide binding]; other site 1034809000243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809000244 ATP binding site [chemical binding]; other site 1034809000245 Mg2+ binding site [ion binding]; other site 1034809000246 G-X-G motif; other site 1034809000248 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809000249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809000250 active site 1034809000251 phosphorylation site [posttranslational modification] 1034809000252 intermolecular recognition site; other site 1034809000253 dimerization interface [polypeptide binding]; other site 1034809000254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809000255 DNA binding site [nucleotide binding] 1034809000257 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034809000258 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1034809000259 Walker A/P-loop; other site 1034809000260 ATP binding site [chemical binding]; other site 1034809000261 Q-loop/lid; other site 1034809000262 ABC transporter signature motif; other site 1034809000263 Walker B; other site 1034809000264 D-loop; other site 1034809000265 H-loop/switch region; other site 1034809000268 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1034809000270 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1034809000272 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1034809000273 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 1034809000275 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1034809000277 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1034809000279 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 1034809000281 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 1034809000283 CDS contains a frameshift after residue 305 1034809000286 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1034809000288 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1034809000289 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1034809000291 predicted helix-turn-helix motif with score1383.000,SD 3.90 at aa 10-31 1034809000292 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1034809000293 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1034809000294 acyl-activating enzyme (AAE) consensus motif; other site 1034809000295 AMP binding site [chemical binding]; other site 1034809000296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809000297 Condensation domain; Region: Condensation; pfam00668 1034809000298 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034809000299 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034809000300 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1034809000301 acyl-activating enzyme (AAE) consensus motif; other site 1034809000302 AMP binding site [chemical binding]; other site 1034809000303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809000304 thioester reductase domain; Region: Thioester-redct; TIGR01746 1034809000305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809000306 NAD(P) binding site [chemical binding]; other site 1034809000307 active site 1034809000318 Protein of unknown function, DUF576; Region: DUF576; cl04553 1034809000320 Protein of unknown function, DUF576; Region: DUF576; cl04553 1034809000322 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1034809000325 Protein of unknown function, DUF576; Region: DUF576; cl04553 1034809000327 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1034809000328 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1034809000330 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1034809000332 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1034809000333 nucleophilic elbow; other site 1034809000334 catalytic triad; other site 1034809000335 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1034809000336 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1034809000337 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034809000338 NAD binding site [chemical binding]; other site 1034809000339 dimer interface [polypeptide binding]; other site 1034809000340 substrate binding site [chemical binding]; other site 1034809000344 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1034809000345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034809000346 DNA-binding site [nucleotide binding]; DNA binding site 1034809000347 UTRA domain; Region: UTRA; pfam07702 1034809000350 predicted helix-turn-helix motif with score1017.000,SD 2.65 at aa 32-53 1034809000352 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1034809000353 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1034809000354 dimer interface [polypeptide binding]; other site 1034809000355 active site 1034809000356 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1034809000358 Class I aldolases; Region: Aldolase_Class_I; cl17187 1034809000361 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1034809000362 active site 1034809000363 phosphorylation site [posttranslational modification] 1034809000365 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1034809000367 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1034809000370 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1034809000371 active pocket/dimerization site; other site 1034809000372 active site 1034809000373 phosphorylation site [posttranslational modification] 1034809000375 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809000376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809000377 active site 1034809000378 phosphorylation site [posttranslational modification] 1034809000379 intermolecular recognition site; other site 1034809000380 dimerization interface [polypeptide binding]; other site 1034809000381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809000382 DNA binding site [nucleotide binding] 1034809000385 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1034809000386 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1034809000387 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1034809000388 Ligand Binding Site [chemical binding]; other site 1034809000389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809000390 dimer interface [polypeptide binding]; other site 1034809000391 phosphorylation site [posttranslational modification] 1034809000392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809000393 ATP binding site [chemical binding]; other site 1034809000394 Mg2+ binding site [ion binding]; other site 1034809000395 G-X-G motif; other site 1034809000399 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1034809000402 potassium-transporting ATPase subunit B; Provisional; Region: PRK14010 1034809000403 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1034809000404 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1034809000408 potassium-transporting ATPase subunit C; Provisional; Region: PRK14000 1034809000410 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1034809000411 NEAr Transporter domain; Region: NEAT; smart00725 1034809000412 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1034809000413 heme-binding site [chemical binding]; other site 1034809000414 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1034809000418 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1034809000420 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1034809000422 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1034809000423 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1034809000424 Walker A/P-loop; other site 1034809000425 ATP binding site [chemical binding]; other site 1034809000426 Q-loop/lid; other site 1034809000427 ABC transporter signature motif; other site 1034809000428 Walker B; other site 1034809000429 D-loop; other site 1034809000430 H-loop/switch region; other site 1034809000431 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1034809000432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809000433 Walker A/P-loop; other site 1034809000434 ATP binding site [chemical binding]; other site 1034809000435 Q-loop/lid; other site 1034809000436 ABC transporter signature motif; other site 1034809000437 Walker B; other site 1034809000438 D-loop; other site 1034809000439 H-loop/switch region; other site 1034809000445 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1034809000446 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1034809000447 heme-binding site [chemical binding]; other site 1034809000448 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1034809000449 heme-binding site [chemical binding]; other site 1034809000454 heme uptake protein IsdC; Region: IsdC; TIGR03656 1034809000455 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1034809000456 heme-binding site [chemical binding]; other site 1034809000457 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1034809000459 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1034809000460 heme-binding site [chemical binding]; other site 1034809000462 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1034809000463 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1034809000464 intersubunit interface [polypeptide binding]; other site 1034809000467 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1034809000468 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809000469 ABC-ATPase subunit interface; other site 1034809000470 dimer interface [polypeptide binding]; other site 1034809000471 putative PBP binding regions; other site 1034809000473 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1034809000474 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1034809000475 Walker A/P-loop; other site 1034809000476 ATP binding site [chemical binding]; other site 1034809000477 Q-loop/lid; other site 1034809000478 ABC transporter signature motif; other site 1034809000479 Walker B; other site 1034809000480 D-loop; other site 1034809000481 H-loop/switch region; other site 1034809000485 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1034809000486 active site 1034809000487 catalytic site [active] 1034809000489 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1034809000491 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1034809000492 CHAP domain; Region: CHAP; pfam05257 1034809000495 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1034809000496 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809000497 ABC-ATPase subunit interface; other site 1034809000498 dimer interface [polypeptide binding]; other site 1034809000499 putative PBP binding regions; other site 1034809000501 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1034809000502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809000503 ABC-ATPase subunit interface; other site 1034809000504 dimer interface [polypeptide binding]; other site 1034809000505 putative PBP binding regions; other site 1034809000507 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1034809000508 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1034809000509 siderophore binding site; other site 1034809000512 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1034809000514 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1034809000515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809000516 Coenzyme A binding pocket [chemical binding]; other site 1034809000517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1034809000519 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1034809000520 MarR family; Region: MarR; pfam01047 1034809000522 predicted helix-turn-helix motif with score1596.000,SD 4.62 at aa 91-112 1034809000524 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1034809000525 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1034809000526 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1034809000529 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1034809000530 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1034809000531 Walker A/P-loop; other site 1034809000532 ATP binding site [chemical binding]; other site 1034809000533 Q-loop/lid; other site 1034809000534 ABC transporter signature motif; other site 1034809000535 Walker B; other site 1034809000536 D-loop; other site 1034809000537 H-loop/switch region; other site 1034809000538 TOBE domain; Region: TOBE_2; pfam08402 1034809000543 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1034809000544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809000545 dimer interface [polypeptide binding]; other site 1034809000546 conserved gate region; other site 1034809000547 ABC-ATPase subunit interface; other site 1034809000550 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1034809000551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1034809000554 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1034809000555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809000556 dimer interface [polypeptide binding]; other site 1034809000557 conserved gate region; other site 1034809000558 putative PBP binding loops; other site 1034809000559 ABC-ATPase subunit interface; other site 1034809000562 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1034809000563 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1034809000564 putative active site [active] 1034809000565 putative metal binding site [ion binding]; other site 1034809000566 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1034809000568 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1034809000569 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1034809000573 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1034809000574 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1034809000575 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1034809000578 predicted helix-turn-helix motif with score1080.000,SD 2.87 at aa 21-42 1034809000580 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1034809000581 catalytic core [active] 1034809000584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034809000585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1034809000586 dimerization interface [polypeptide binding]; other site 1034809000587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809000588 dimer interface [polypeptide binding]; other site 1034809000589 phosphorylation site [posttranslational modification] 1034809000590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809000591 ATP binding site [chemical binding]; other site 1034809000592 Mg2+ binding site [ion binding]; other site 1034809000593 G-X-G motif; other site 1034809000597 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809000598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809000599 active site 1034809000600 phosphorylation site [posttranslational modification] 1034809000601 intermolecular recognition site; other site 1034809000602 dimerization interface [polypeptide binding]; other site 1034809000603 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809000604 DNA binding site [nucleotide binding] 1034809000607 DoxX; Region: DoxX; pfam07681 1034809000609 Electron transfer DM13; Region: DM13; cl02735 1034809000613 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034809000614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1034809000615 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034809000616 dimerization interface [polypeptide binding]; other site 1034809000619 predicted helix-turn-helix motif with score1360.000,SD 3.82 at aa 16-37 1034809000620 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1034809000621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809000622 Walker A/P-loop; other site 1034809000623 ATP binding site [chemical binding]; other site 1034809000624 Q-loop/lid; other site 1034809000625 ABC transporter signature motif; other site 1034809000626 Walker B; other site 1034809000627 D-loop; other site 1034809000628 H-loop/switch region; other site 1034809000629 TOBE domain; Region: TOBE_2; pfam08402 1034809000635 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1034809000636 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1034809000639 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1034809000640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809000641 dimer interface [polypeptide binding]; other site 1034809000642 conserved gate region; other site 1034809000643 putative PBP binding loops; other site 1034809000644 ABC-ATPase subunit interface; other site 1034809000645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809000646 dimer interface [polypeptide binding]; other site 1034809000647 conserved gate region; other site 1034809000648 putative PBP binding loops; other site 1034809000649 ABC-ATPase subunit interface; other site 1034809000653 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1034809000654 active site 1034809000655 metal binding site [ion binding]; metal-binding site 1034809000657 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1034809000658 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1034809000659 Bacterial transcriptional regulator; Region: IclR; pfam01614 1034809000663 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1034809000664 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1034809000665 substrate binding site [chemical binding]; other site 1034809000666 ATP binding site [chemical binding]; other site 1034809000669 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1034809000670 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1034809000671 active site 1034809000672 intersubunit interface [polypeptide binding]; other site 1034809000673 catalytic residue [active] 1034809000675 galactonate dehydratase; Provisional; Region: PRK14017 1034809000676 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1034809000677 putative active site pocket [active] 1034809000678 putative metal binding site [ion binding]; other site 1034809000684 gluconate transporter; Region: gntP; TIGR00791 1034809000685 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1034809000687 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1034809000689 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1034809000690 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1034809000691 DNA binding residues [nucleotide binding] 1034809000693 predicted helix-turn-helix motif with score2155.000,SD 6.53 at aa 1-22 1034809000694 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1034809000695 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1034809000696 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1034809000697 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1034809000698 active site 1034809000699 dimer interface [polypeptide binding]; other site 1034809000700 motif 1; other site 1034809000701 motif 2; other site 1034809000702 motif 3; other site 1034809000703 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1034809000704 anticodon binding site; other site 1034809000712 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1034809000713 hypothetical protein; Provisional; Region: PRK06184 1034809000715 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1034809000719 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1034809000720 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1034809000721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809000722 Walker A motif; other site 1034809000723 ATP binding site [chemical binding]; other site 1034809000724 Walker B motif; other site 1034809000725 arginine finger; other site 1034809000726 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1034809000727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809000728 Walker A motif; other site 1034809000729 ATP binding site [chemical binding]; other site 1034809000730 Walker B motif; other site 1034809000731 arginine finger; other site 1034809000736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809000737 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034809000738 active site 1034809000739 motif I; other site 1034809000740 motif II; other site 1034809000741 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1034809000743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809000744 benzoate transport; Region: 2A0115; TIGR00895 1034809000745 putative substrate translocation pore; other site 1034809000746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809000751 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1034809000752 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1034809000753 substrate binding site [chemical binding]; other site 1034809000757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1034809000758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809000759 dimer interface [polypeptide binding]; other site 1034809000760 conserved gate region; other site 1034809000761 putative PBP binding loops; other site 1034809000762 ABC-ATPase subunit interface; other site 1034809000764 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1034809000765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809000766 dimer interface [polypeptide binding]; other site 1034809000767 conserved gate region; other site 1034809000768 putative PBP binding loops; other site 1034809000769 ABC-ATPase subunit interface; other site 1034809000771 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1034809000772 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1034809000773 Walker A/P-loop; other site 1034809000774 ATP binding site [chemical binding]; other site 1034809000775 Q-loop/lid; other site 1034809000776 ABC transporter signature motif; other site 1034809000777 Walker B; other site 1034809000778 D-loop; other site 1034809000779 H-loop/switch region; other site 1034809000780 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034809000784 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1034809000785 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1034809000786 Walker A/P-loop; other site 1034809000787 ATP binding site [chemical binding]; other site 1034809000788 Q-loop/lid; other site 1034809000789 ABC transporter signature motif; other site 1034809000790 Walker B; other site 1034809000791 D-loop; other site 1034809000792 H-loop/switch region; other site 1034809000796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809000797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809000798 putative substrate translocation pore; other site 1034809000800 Peptidase M30; Region: Peptidase_M30; pfam10460 1034809000801 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1034809000804 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1034809000805 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1034809000806 conserved cys residue [active] 1034809000808 amino acid transporter; Region: 2A0306; TIGR00909 1034809000810 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1034809000812 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1034809000813 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1034809000814 catalytic triad [active] 1034809000817 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1034809000818 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1034809000820 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1034809000821 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1034809000822 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034809000823 active site turn [active] 1034809000824 phosphorylation site [posttranslational modification] 1034809000825 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1034809000826 HPr interaction site; other site 1034809000827 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1034809000828 active site 1034809000829 phosphorylation site [posttranslational modification] 1034809000835 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1034809000836 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1034809000837 intersubunit interface [polypeptide binding]; other site 1034809000841 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1034809000843 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1034809000846 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1034809000847 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1034809000848 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1034809000851 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1034809000852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809000853 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1034809000855 predicted helix-turn-helix motif with score1601.000,SD 4.64 at aa 28-49 1034809000856 MMPL family; Region: MMPL; pfam03176 1034809000857 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1034809000859 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1034809000860 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1034809000861 NADP binding site [chemical binding]; other site 1034809000862 putative substrate binding site [chemical binding]; other site 1034809000863 active site 1034809000866 Predicted membrane protein [Function unknown]; Region: COG3212 1034809000867 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1034809000870 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1034809000871 Pyruvate formate lyase 1; Region: PFL1; cd01678 1034809000872 coenzyme A binding site [chemical binding]; other site 1034809000873 active site 1034809000874 catalytic residues [active] 1034809000875 glycine loop; other site 1034809000879 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1034809000880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034809000881 FeS/SAM binding site; other site 1034809000882 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1034809000885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034809000886 dimerization interface [polypeptide binding]; other site 1034809000887 putative DNA binding site [nucleotide binding]; other site 1034809000888 putative Zn2+ binding site [ion binding]; other site 1034809000890 predicted helix-turn-helix motif with score1073.000,SD 2.84 at aa 30-51 1034809000891 arsenical pump membrane protein; Provisional; Region: PRK15445 1034809000892 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1034809000893 transmembrane helices; other site 1034809000897 CDS contains a frameshift after residue 125 1034809000899 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1034809000900 acetoin reductases; Region: 23BDH; TIGR02415 1034809000901 NAD binding site [chemical binding]; other site 1034809000902 homotetramer interface [polypeptide binding]; other site 1034809000903 homodimer interface [polypeptide binding]; other site 1034809000904 active site 1034809000905 substrate binding site [chemical binding]; other site 1034809000907 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1034809000908 DNA-binding site [nucleotide binding]; DNA binding site 1034809000909 RNA-binding motif; other site 1034809000912 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1034809000913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809000914 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1034809000916 predicted helix-turn-helix motif with score1013.000,SD 2.64 at aa 30-51 1034809000917 Predicted acyl esterases [General function prediction only]; Region: COG2936 1034809000918 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1034809000921 Predicted membrane protein [Function unknown]; Region: COG2311 1034809000922 Protein of unknown function (DUF418); Region: DUF418; cl12135 1034809000923 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1034809000926 TspO/MBR family; Region: TspO_MBR; pfam03073 1034809000928 phytoene desaturase; Region: crtI_fam; TIGR02734 1034809000929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1034809000931 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034809000932 active site 1034809000933 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1034809000935 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1034809000936 active site lid residues [active] 1034809000937 substrate binding pocket [chemical binding]; other site 1034809000938 catalytic residues [active] 1034809000939 substrate-Mg2+ binding site; other site 1034809000940 aspartate-rich region 1; other site 1034809000941 aspartate-rich region 2; other site 1034809000944 phytoene desaturase; Region: crtI_fam; TIGR02734 1034809000945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1034809000948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809000949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809000950 putative substrate translocation pore; other site 1034809000955 MepB protein; Region: MepB; pfam08877 1034809000957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809000958 Walker A/P-loop; other site 1034809000959 ATP binding site [chemical binding]; other site 1034809000960 ABC transporter; Region: ABC_tran; pfam00005 1034809000961 Q-loop/lid; other site 1034809000962 ABC transporter signature motif; other site 1034809000963 Walker B; other site 1034809000964 D-loop; other site 1034809000965 H-loop/switch region; other site 1034809000969 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1034809000971 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1034809000972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809000973 S-adenosylmethionine binding site [chemical binding]; other site 1034809000976 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1034809000977 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1034809000981 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1034809000982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809000983 dimer interface [polypeptide binding]; other site 1034809000984 conserved gate region; other site 1034809000985 putative PBP binding loops; other site 1034809000986 ABC-ATPase subunit interface; other site 1034809000987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1034809000989 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1034809000990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809000991 dimer interface [polypeptide binding]; other site 1034809000992 conserved gate region; other site 1034809000993 putative PBP binding loops; other site 1034809000994 ABC-ATPase subunit interface; other site 1034809000996 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1034809000997 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1034809000998 Walker A/P-loop; other site 1034809000999 ATP binding site [chemical binding]; other site 1034809001000 Q-loop/lid; other site 1034809001001 ABC transporter signature motif; other site 1034809001002 Walker B; other site 1034809001003 D-loop; other site 1034809001004 H-loop/switch region; other site 1034809001008 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1034809001009 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034809001010 Walker A/P-loop; other site 1034809001011 ATP binding site [chemical binding]; other site 1034809001012 Q-loop/lid; other site 1034809001013 ABC transporter signature motif; other site 1034809001014 Walker B; other site 1034809001015 D-loop; other site 1034809001016 H-loop/switch region; other site 1034809001020 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1034809001021 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1034809001022 dimer interface [polypeptide binding]; other site 1034809001023 PYR/PP interface [polypeptide binding]; other site 1034809001024 TPP binding site [chemical binding]; other site 1034809001025 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1034809001026 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1034809001027 TPP-binding site [chemical binding]; other site 1034809001028 dimer interface [polypeptide binding]; other site 1034809001032 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1034809001033 MarR family; Region: MarR_2; pfam12802 1034809001034 predicted helix-turn-helix motif with score1010.000,SD 2.63 at aa 33-54 1034809001037 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1034809001038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809001039 Walker A/P-loop; other site 1034809001040 ATP binding site [chemical binding]; other site 1034809001041 Q-loop/lid; other site 1034809001042 ABC transporter signature motif; other site 1034809001043 Walker B; other site 1034809001044 D-loop; other site 1034809001045 H-loop/switch region; other site 1034809001049 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1034809001050 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1034809001052 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1034809001055 Predicted membrane protein [Function unknown]; Region: COG1288 1034809001057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809001058 putative substrate translocation pore; other site 1034809001059 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1034809001063 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1034809001065 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1034809001066 classical (c) SDRs; Region: SDR_c; cd05233 1034809001067 NAD(P) binding site [chemical binding]; other site 1034809001068 active site 1034809001070 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1034809001071 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1034809001072 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034809001073 active site turn [active] 1034809001074 phosphorylation site [posttranslational modification] 1034809001079 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 1034809001080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809001081 NAD(P) binding site [chemical binding]; other site 1034809001082 active site 1034809001084 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 1034809001085 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 1034809001086 putative catalytic cysteine [active] 1034809001088 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1034809001089 predicted helix-turn-helix motif with score1245.000,SD 3.43 at aa 38-59 1034809001090 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1034809001092 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1034809001093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809001096 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1034809001097 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1034809001098 putative active site [active] 1034809001099 putative FMN binding site [chemical binding]; other site 1034809001100 putative substrate binding site [chemical binding]; other site 1034809001101 putative catalytic residue [active] 1034809001102 FMN-binding domain; Region: FMN_bind; cl01081 1034809001103 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1034809001104 L-aspartate oxidase; Provisional; Region: PRK06175 1034809001106 predicted helix-turn-helix motif with score1054.000,SD 2.78 at aa 883-904 1034809001109 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1034809001110 ApbE family; Region: ApbE; pfam02424 1034809001112 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1034809001113 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1034809001114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034809001115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809001116 homodimer interface [polypeptide binding]; other site 1034809001117 catalytic residue [active] 1034809001119 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1034809001120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1034809001121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809001122 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034809001126 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1034809001127 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1034809001128 tetramer interface [polypeptide binding]; other site 1034809001129 TPP-binding site [chemical binding]; other site 1034809001130 heterodimer interface [polypeptide binding]; other site 1034809001131 phosphorylation loop region [posttranslational modification] 1034809001133 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1034809001134 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1034809001135 alpha subunit interface [polypeptide binding]; other site 1034809001136 TPP binding site [chemical binding]; other site 1034809001137 heterodimer interface [polypeptide binding]; other site 1034809001138 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1034809001141 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1034809001142 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1034809001143 E3 interaction surface; other site 1034809001144 lipoyl attachment site [posttranslational modification]; other site 1034809001145 e3 binding domain; Region: E3_binding; pfam02817 1034809001146 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1034809001150 Predicted transcriptional regulators [Transcription]; Region: COG1695 1034809001151 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1034809001153 hypothetical protein; Validated; Region: PRK07668 1034809001155 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1034809001156 HTH domain; Region: HTH_11; pfam08279 1034809001157 PRD domain; Region: PRD; pfam00874 1034809001158 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1034809001159 active site 1034809001160 P-loop; other site 1034809001161 phosphorylation site [posttranslational modification] 1034809001162 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034809001163 active site 1034809001164 phosphorylation site [posttranslational modification] 1034809001166 predicted helix-turn-helix motif with score1182.000,SD 3.21 at aa 20-41 1034809001169 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1034809001170 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1034809001171 active site 1034809001172 P-loop; other site 1034809001173 phosphorylation site [posttranslational modification] 1034809001174 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1034809001175 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034809001176 active site 1034809001177 phosphorylation site [posttranslational modification] 1034809001182 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1034809001183 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1034809001185 NMT1/THI5 like; Region: NMT1; pfam09084 1034809001187 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034809001188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809001189 non-specific DNA binding site [nucleotide binding]; other site 1034809001190 salt bridge; other site 1034809001191 sequence-specific DNA binding site [nucleotide binding]; other site 1034809001193 predicted helix-turn-helix motif with score2215.000,SD 6.73 at aa 17-38 1034809001194 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1034809001198 ornithine decarboxylase; Provisional; Region: PRK13578 1034809001199 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1034809001200 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034809001201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034809001202 catalytic residue [active] 1034809001203 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1034809001208 putrescine-ornithine antiporter; Region: antiport_PotE; TIGR04299 1034809001211 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1034809001212 Cation efflux family; Region: Cation_efflux; cl00316 1034809001215 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1034809001216 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034809001217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809001218 non-specific DNA binding site [nucleotide binding]; other site 1034809001219 salt bridge; other site 1034809001220 sequence-specific DNA binding site [nucleotide binding]; other site 1034809001222 predicted helix-turn-helix motif with score1699.000,SD 4.97 at aa 3-35 1034809001223 predicted helix-turn-helix motif with score1699.000,SD 4.97 at aa 14-35 1034809001224 predicted helix-turn-helix motif with score1230.000,SD 3.38 at aa 3-24 1034809001225 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1034809001226 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1034809001227 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1034809001230 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1034809001231 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1034809001232 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1034809001233 putative ADP-ribose binding site [chemical binding]; other site 1034809001236 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1034809001237 lipoyl attachment site [posttranslational modification]; other site 1034809001239 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1034809001240 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1034809001242 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1034809001243 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1034809001244 putative active site [active] 1034809001245 putative FMN binding site [chemical binding]; other site 1034809001246 putative substrate binding site [chemical binding]; other site 1034809001247 putative catalytic residue [active] 1034809001249 BCCT family transporter; Region: BCCT; pfam02028 1034809001251 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1034809001252 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1034809001253 active site 1034809001254 dimer interface [polypeptide binding]; other site 1034809001256 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1034809001257 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1034809001258 active site 1034809001259 trimer interface [polypeptide binding]; other site 1034809001260 allosteric site; other site 1034809001261 active site lid [active] 1034809001262 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1034809001264 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1034809001265 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1034809001266 putative active site cavity [active] 1034809001268 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1034809001269 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1034809001270 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1034809001271 putative active site [active] 1034809001273 predicted helix-turn-helix motif with score1183.000,SD 3.22 at aa 36-57 1034809001275 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1034809001276 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1034809001277 nucleotide binding site [chemical binding]; other site 1034809001279 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1034809001280 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1034809001281 inhibitor site; inhibition site 1034809001282 active site 1034809001283 dimer interface [polypeptide binding]; other site 1034809001284 catalytic residue [active] 1034809001286 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1034809001287 putative transporter; Provisional; Region: PRK10484 1034809001288 Na binding site [ion binding]; other site 1034809001291 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1034809001292 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1034809001293 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1034809001297 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1034809001299 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1034809001300 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1034809001301 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1034809001302 substrate binding site [chemical binding]; other site 1034809001303 ATP binding site [chemical binding]; other site 1034809001306 predicted helix-turn-helix motif with score1833.000,SD 5.43 at aa 18-39 1034809001307 CAAX protease self-immunity; Region: Abi; pfam02517 1034809001310 CAAX protease self-immunity; Region: Abi; pfam02517 1034809001312 CAAX protease self-immunity; Region: Abi; pfam02517 1034809001314 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1034809001315 putative substrate binding pocket [chemical binding]; other site 1034809001316 AC domain interface; other site 1034809001317 catalytic triad [active] 1034809001318 AB domain interface; other site 1034809001319 interchain disulfide; other site 1034809001322 Predicted membrane protein [Function unknown]; Region: COG3817 1034809001323 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1034809001325 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1034809001327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809001328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809001330 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1034809001331 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1034809001332 active site 1034809001334 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1034809001335 HTH domain; Region: HTH_11; cl17392 1034809001336 HTH domain; Region: HTH_11; pfam08279 1034809001337 PRD domain; Region: PRD; pfam00874 1034809001338 PRD domain; Region: PRD; pfam00874 1034809001339 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1034809001340 active site 1034809001341 P-loop; other site 1034809001342 phosphorylation site [posttranslational modification] 1034809001343 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034809001344 active site 1034809001345 phosphorylation site [posttranslational modification] 1034809001347 predicted helix-turn-helix motif with score1747.000,SD 5.14 at aa 20-41 1034809001349 predicted helix-turn-helix motif with score1397.000,SD 3.94 at aa 104-125 1034809001354 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034809001355 active site 1034809001356 phosphorylation site [posttranslational modification] 1034809001358 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1034809001359 active site 1034809001360 P-loop; other site 1034809001361 phosphorylation site [posttranslational modification] 1034809001363 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1034809001366 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1034809001367 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1034809001368 active site residue [active] 1034809001369 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1034809001371 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1034809001372 Strictosidine synthase; Region: Str_synth; pfam03088 1034809001374 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034809001375 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1034809001376 active site 1034809001377 metal binding site [ion binding]; metal-binding site 1034809001379 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1034809001380 hydrophobic ligand binding site; other site 1034809001382 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1034809001383 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1034809001384 substrate binding site [chemical binding]; other site 1034809001385 dimer interface [polypeptide binding]; other site 1034809001386 ATP binding site [chemical binding]; other site 1034809001391 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1034809001394 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1034809001395 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1034809001396 Walker A/P-loop; other site 1034809001397 ATP binding site [chemical binding]; other site 1034809001398 Q-loop/lid; other site 1034809001399 ABC transporter signature motif; other site 1034809001400 Walker B; other site 1034809001401 D-loop; other site 1034809001402 H-loop/switch region; other site 1034809001406 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1034809001407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809001408 non-specific DNA binding site [nucleotide binding]; other site 1034809001409 salt bridge; other site 1034809001410 sequence-specific DNA binding site [nucleotide binding]; other site 1034809001412 predicted helix-turn-helix motif with score2200.000,SD 6.68 at aa 14-35 1034809001413 Tic20-like protein; Region: Tic20; pfam09685 1034809001414 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1034809001415 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1034809001416 NADP binding site [chemical binding]; other site 1034809001419 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1034809001420 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1034809001423 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1034809001424 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1034809001425 CHAP domain; Region: CHAP; pfam05257 1034809001428 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1034809001429 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1034809001430 Predicted membrane protein [Function unknown]; Region: COG1511 1034809001431 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1034809001433 YolD-like protein; Region: YolD; pfam08863 1034809001435 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1034809001436 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1034809001437 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1034809001438 active site 1034809001439 DNA binding site [nucleotide binding] 1034809001440 Int/Topo IB signature motif; other site 1034809001444 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1034809001445 active site 1034809001446 DNA binding site [nucleotide binding] 1034809001447 Int/Topo IB signature motif; other site 1034809001449 predicted helix-turn-helix motif with score1305.000,SD 3.63 at aa 39-60 1034809001450 YolD-like protein; Region: YolD; pfam08863 1034809001452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034809001453 dimerization interface [polypeptide binding]; other site 1034809001454 putative DNA binding site [nucleotide binding]; other site 1034809001455 putative Zn2+ binding site [ion binding]; other site 1034809001457 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1034809001458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809001459 S-adenosylmethionine binding site [chemical binding]; other site 1034809001460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1034809001461 arginine deiminase; Provisional; Region: PRK01388 1034809001463 Predicted esterase [General function prediction only]; Region: COG0627 1034809001464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1034809001466 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1034809001467 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1034809001468 putative active site [active] 1034809001469 putative metal binding site [ion binding]; other site 1034809001472 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1034809001474 azoreductase; Reviewed; Region: PRK00170 1034809001475 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1034809001478 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 1034809001479 Chain length determinant protein; Region: Wzz; cl15801 1034809001481 predicted helix-turn-helix motif with score1165.000,SD 3.15 at aa 57-78 1034809001482 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1034809001483 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1034809001484 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1034809001486 CDS contains a frameshift after residue 141 1034809001488 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1034809001489 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1034809001490 NAD(P) binding site [chemical binding]; other site 1034809001491 homodimer interface [polypeptide binding]; other site 1034809001492 substrate binding site [chemical binding]; other site 1034809001493 active site 1034809001494 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1034809001497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809001498 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1034809001499 NAD(P) binding site [chemical binding]; other site 1034809001500 active site 1034809001501 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1034809001503 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1034809001504 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1034809001505 active site 1034809001506 homodimer interface [polypeptide binding]; other site 1034809001508 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1034809001509 trimer interface [polypeptide binding]; other site 1034809001510 active site 1034809001511 substrate binding site [chemical binding]; other site 1034809001512 CoA binding site [chemical binding]; other site 1034809001517 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1034809001518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034809001520 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 1034809001521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034809001522 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1034809001523 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1034809001526 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1034809001527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809001528 NAD(P) binding site [chemical binding]; other site 1034809001529 active site 1034809001531 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1034809001532 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1034809001533 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1034809001537 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1034809001538 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1034809001539 active site 1034809001540 homodimer interface [polypeptide binding]; other site 1034809001542 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1034809001543 dimer interface [polypeptide binding]; other site 1034809001544 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1034809001545 active site 1034809001546 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1034809001549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809001550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809001551 active site 1034809001552 phosphorylation site [posttranslational modification] 1034809001553 intermolecular recognition site; other site 1034809001554 dimerization interface [polypeptide binding]; other site 1034809001555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809001556 DNA binding site [nucleotide binding] 1034809001559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034809001560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809001561 ATP binding site [chemical binding]; other site 1034809001562 Mg2+ binding site [ion binding]; other site 1034809001563 G-X-G motif; other site 1034809001565 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034809001566 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1034809001567 Walker A/P-loop; other site 1034809001568 ATP binding site [chemical binding]; other site 1034809001569 Q-loop/lid; other site 1034809001570 ABC transporter signature motif; other site 1034809001571 Walker B; other site 1034809001572 D-loop; other site 1034809001573 H-loop/switch region; other site 1034809001576 FtsX-like permease family; Region: FtsX; pfam02687 1034809001579 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1034809001580 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1034809001581 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1034809001582 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1034809001583 active site 1034809001584 non-prolyl cis peptide bond; other site 1034809001586 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 1034809001587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809001588 NAD(P) binding site [chemical binding]; other site 1034809001589 active site 1034809001591 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1034809001592 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1034809001593 Putative Ig domain; Region: He_PIG; pfam05345 1034809001594 Putative Ig domain; Region: He_PIG; pfam05345 1034809001595 Putative Ig domain; Region: He_PIG; pfam05345 1034809001596 Putative Ig domain; Region: He_PIG; pfam05345 1034809001597 Putative Ig domain; Region: He_PIG; pfam05345 1034809001598 Putative Ig domain; Region: He_PIG; pfam05345 1034809001599 Cadherin repeat-like domain; Region: CA_like; cl15786 1034809001600 Ca2+ binding site [ion binding]; other site 1034809001611 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1034809001612 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1034809001613 Cna protein B-type domain; Region: Cna_B; pfam05738 1034809001614 Cna protein B-type domain; Region: Cna_B; pfam05738 1034809001615 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 1034809001623 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1034809001624 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1034809001625 Active Sites [active] 1034809001628 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1034809001629 Flavodoxin; Region: Flavodoxin_1; pfam00258 1034809001630 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1034809001631 FAD binding pocket [chemical binding]; other site 1034809001632 FAD binding motif [chemical binding]; other site 1034809001633 catalytic residues [active] 1034809001634 NAD binding pocket [chemical binding]; other site 1034809001635 phosphate binding motif [ion binding]; other site 1034809001636 beta-alpha-beta structure motif; other site 1034809001640 sulfite reductase subunit beta; Provisional; Region: PRK13504 1034809001641 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1034809001642 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1034809001647 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1034809001648 active site 1034809001649 SAM binding site [chemical binding]; other site 1034809001650 homodimer interface [polypeptide binding]; other site 1034809001653 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1034809001654 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1034809001655 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1034809001656 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 1034809001658 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1034809001659 ATP-sulfurylase; Region: ATPS; cd00517 1034809001660 active site 1034809001661 HXXH motif; other site 1034809001662 flexible loop; other site 1034809001664 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1034809001665 ligand-binding site [chemical binding]; other site 1034809001668 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1034809001669 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1034809001670 metal binding site [ion binding]; metal-binding site 1034809001671 dimer interface [polypeptide binding]; other site 1034809001675 CHAP domain; Region: CHAP; pfam05257 1034809001676 Surface antigen [General function prediction only]; Region: COG3942 1034809001679 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1034809001680 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1034809001681 effector binding site; other site 1034809001682 active site 1034809001683 Zn binding site [ion binding]; other site 1034809001684 glycine loop; other site 1034809001687 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1034809001688 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1034809001689 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1034809001690 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1034809001692 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1034809001696 Predicted transcriptional regulators [Transcription]; Region: COG1510 1034809001697 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1034809001698 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1034809001699 tetramerization interface [polypeptide binding]; other site 1034809001700 NAD(P) binding site [chemical binding]; other site 1034809001701 catalytic residues [active] 1034809001705 choline dehydrogenase; Validated; Region: PRK02106 1034809001706 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1034809001712 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1034809001713 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1034809001714 metal binding site [ion binding]; metal-binding site 1034809001715 dimer interface [polypeptide binding]; other site 1034809001718 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 1034809001720 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1034809001722 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1034809001723 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1034809001724 active site 1034809001725 acyl-activating enzyme (AAE) consensus motif; other site 1034809001726 putative CoA binding site [chemical binding]; other site 1034809001727 AMP binding site [chemical binding]; other site 1034809001730 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1034809001731 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1034809001732 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1034809001733 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1034809001738 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1034809001740 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1034809001741 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1034809001744 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1034809001745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034809001746 DNA-binding site [nucleotide binding]; DNA binding site 1034809001747 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1034809001750 predicted helix-turn-helix motif with score1063.000,SD 2.81 at aa 27-48 1034809001751 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034809001752 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1034809001753 active site turn [active] 1034809001754 phosphorylation site [posttranslational modification] 1034809001755 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1034809001756 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1034809001757 HPr interaction site; other site 1034809001758 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1034809001759 active site 1034809001760 phosphorylation site [posttranslational modification] 1034809001765 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1034809001766 beta-galactosidase; Region: BGL; TIGR03356 1034809001771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034809001772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1034809001773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034809001774 dimerization interface [polypeptide binding]; other site 1034809001777 predicted helix-turn-helix motif with score1123.000,SD 3.01 at aa 48-69 1034809001778 Predicted transcriptional regulators [Transcription]; Region: COG1695 1034809001779 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1034809001781 hypothetical protein; Provisional; Region: PRK07236 1034809001782 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1034809001783 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1034809001785 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1034809001786 catalytic residue [active] 1034809001789 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1034809001791 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1034809001792 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1034809001796 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1034809001797 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034809001798 inhibitor-cofactor binding pocket; inhibition site 1034809001799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809001800 catalytic residue [active] 1034809001803 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1034809001804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034809001805 active site 1034809001807 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1034809001808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034809001809 active site 1034809001811 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1034809001812 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1034809001814 amino acid transporter; Region: 2A0306; TIGR00909 1034809001815 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1034809001817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034809001818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1034809001819 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1034809001820 putative dimerization interface [polypeptide binding]; other site 1034809001822 predicted helix-turn-helix motif with score1578.000,SD 4.56 at aa 16-37 1034809001826 acetolactate synthase; Reviewed; Region: PRK08617 1034809001827 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1034809001828 PYR/PP interface [polypeptide binding]; other site 1034809001829 dimer interface [polypeptide binding]; other site 1034809001830 TPP binding site [chemical binding]; other site 1034809001831 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1034809001832 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1034809001833 TPP-binding site [chemical binding]; other site 1034809001838 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1034809001841 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1034809001842 L-lactate permease; Region: Lactate_perm; cl00701 1034809001844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1034809001846 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1034809001847 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1034809001848 quinone interaction residues [chemical binding]; other site 1034809001849 active site 1034809001850 catalytic residues [active] 1034809001851 FMN binding site [chemical binding]; other site 1034809001852 substrate binding site [chemical binding]; other site 1034809001856 Phosphotransferase enzyme family; Region: APH; pfam01636 1034809001857 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1034809001858 active site 1034809001859 ATP binding site [chemical binding]; other site 1034809001860 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1034809001862 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1034809001864 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1034809001866 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1034809001867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809001868 NAD(P) binding site [chemical binding]; other site 1034809001869 active site 1034809001872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034809001873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809001876 predicted helix-turn-helix motif with score1809.000,SD 5.35 at aa 28-49 1034809001877 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 1034809001879 predicted helix-turn-helix motif with score1380.000,SD 3.89 at aa 24-45 1034809001880 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1034809001881 NmrA-like family; Region: NmrA; pfam05368 1034809001882 NADP binding site [chemical binding]; other site 1034809001883 active site 1034809001884 regulatory binding site [polypeptide binding]; other site 1034809001886 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1034809001887 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034809001889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1034809001891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034809001892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809001894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809001895 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1034809001896 putative substrate translocation pore; other site 1034809001897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809001899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034809001900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809001902 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1034809001905 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1034809001906 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1034809001908 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1034809001910 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1034809001911 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1034809001912 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1034809001915 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1034809001916 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1034809001917 catalytic residue [active] 1034809001919 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1034809001920 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1034809001921 catalytic triad [active] 1034809001922 catalytic triad [active] 1034809001923 oxyanion hole [active] 1034809001925 transaminase; Reviewed; Region: PRK08068 1034809001926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034809001927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809001928 homodimer interface [polypeptide binding]; other site 1034809001929 catalytic residue [active] 1034809001932 D-lactate dehydrogenase; Validated; Region: PRK08605 1034809001933 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1034809001934 homodimer interface [polypeptide binding]; other site 1034809001935 ligand binding site [chemical binding]; other site 1034809001936 NAD binding site [chemical binding]; other site 1034809001937 catalytic site [active] 1034809001943 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1034809001944 metal-binding site [ion binding] 1034809001947 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1034809001948 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1034809001949 metal-binding site [ion binding] 1034809001950 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1034809001951 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1034809001952 metal-binding site [ion binding] 1034809001953 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1034809001954 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1034809001964 maltose O-acetyltransferase; Provisional; Region: PRK10092 1034809001965 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1034809001966 active site 1034809001967 substrate binding site [chemical binding]; other site 1034809001968 trimer interface [polypeptide binding]; other site 1034809001969 CoA binding site [chemical binding]; other site 1034809001973 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1034809001974 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1034809001975 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1034809001976 putative ADP-binding pocket [chemical binding]; other site 1034809001977 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034809001980 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1034809001981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809001982 NAD(P) binding site [chemical binding]; other site 1034809001983 active site 1034809001985 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1034809001986 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1034809001987 Glutamate binding site [chemical binding]; other site 1034809001988 homodimer interface [polypeptide binding]; other site 1034809001989 NAD binding site [chemical binding]; other site 1034809001990 catalytic residues [active] 1034809001994 MMPL family; Region: MMPL; pfam03176 1034809001995 MMPL family; Region: MMPL; pfam03176 1034809001996 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1034809001999 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1034809002000 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1034809002001 oligomer interface [polypeptide binding]; other site 1034809002002 metal binding site [ion binding]; metal-binding site 1034809002003 metal binding site [ion binding]; metal-binding site 1034809002004 putative Cl binding site [ion binding]; other site 1034809002005 aspartate ring; other site 1034809002006 basic sphincter; other site 1034809002007 hydrophobic gate; other site 1034809002008 periplasmic entrance; other site 1034809002010 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1034809002011 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1034809002012 DNA binding site [nucleotide binding] 1034809002013 active site 1034809002016 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1034809002018 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1034809002020 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1034809002022 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1034809002023 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1034809002025 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1034809002026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809002027 Walker A/P-loop; other site 1034809002028 ATP binding site [chemical binding]; other site 1034809002029 Q-loop/lid; other site 1034809002030 ABC transporter signature motif; other site 1034809002031 Walker B; other site 1034809002032 D-loop; other site 1034809002033 H-loop/switch region; other site 1034809002037 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1034809002038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809002040 predicted helix-turn-helix motif with score1158.000,SD 3.13 at aa 34-55 1034809002041 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1034809002042 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1034809002043 dimer interface [polypeptide binding]; other site 1034809002044 active site 1034809002047 putative acyltransferase; Provisional; Region: PRK05790 1034809002048 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1034809002049 dimer interface [polypeptide binding]; other site 1034809002050 active site 1034809002056 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1034809002057 homodimer interface [polypeptide binding]; other site 1034809002058 catalytic residues [active] 1034809002059 NAD binding site [chemical binding]; other site 1034809002060 substrate binding pocket [chemical binding]; other site 1034809002061 flexible flap; other site 1034809002065 Surface antigen [General function prediction only]; Region: COG3942 1034809002066 CHAP domain; Region: CHAP; pfam05257 1034809002068 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1034809002070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034809002071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1034809002072 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1034809002073 putative dimerization interface [polypeptide binding]; other site 1034809002075 predicted helix-turn-helix motif with score1291.000,SD 3.58 at aa 16-37 1034809002078 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1034809002080 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1034809002082 pyruvate oxidase; Provisional; Region: PRK08611 1034809002083 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1034809002084 PYR/PP interface [polypeptide binding]; other site 1034809002085 tetramer interface [polypeptide binding]; other site 1034809002086 dimer interface [polypeptide binding]; other site 1034809002087 TPP binding site [chemical binding]; other site 1034809002088 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1034809002089 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1034809002090 TPP-binding site [chemical binding]; other site 1034809002096 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1034809002097 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1034809002098 catalytic Zn binding site [ion binding]; other site 1034809002099 structural Zn binding site [ion binding]; other site 1034809002100 NAD(P) binding site [chemical binding]; other site 1034809002105 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1034809002106 active site 1034809002107 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034809002108 catalytic residues [active] 1034809002109 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1034809002110 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1034809002111 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034809002112 NAD binding site [chemical binding]; other site 1034809002113 dimer interface [polypeptide binding]; other site 1034809002114 substrate binding site [chemical binding]; other site 1034809002119 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1034809002120 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1034809002123 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1034809002124 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034809002126 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 1034809002128 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1034809002129 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1034809002130 putative active site [active] 1034809002131 putative metal binding site [ion binding]; other site 1034809002133 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1034809002134 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1034809002136 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1034809002137 N- and C-terminal domain interface [polypeptide binding]; other site 1034809002138 D-xylulose kinase; Region: XylB; TIGR01312 1034809002139 active site 1034809002140 MgATP binding site [chemical binding]; other site 1034809002141 catalytic site [active] 1034809002142 metal binding site [ion binding]; metal-binding site 1034809002143 xylulose binding site [chemical binding]; other site 1034809002144 homodimer interface [polypeptide binding]; other site 1034809002149 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1034809002150 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1034809002152 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1034809002153 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1034809002155 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1034809002156 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1034809002159 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1034809002160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809002161 Coenzyme A binding pocket [chemical binding]; other site 1034809002163 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1034809002164 active site 1034809002165 catalytic site [active] 1034809002167 CDS contains a frameshift after residue 1687 1034809002172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809002173 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034809002174 active site 1034809002175 motif I; other site 1034809002176 motif II; other site 1034809002179 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1034809002181 D-lactate dehydrogenase; Provisional; Region: PRK12480 1034809002182 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1034809002183 homodimer interface [polypeptide binding]; other site 1034809002184 ligand binding site [chemical binding]; other site 1034809002185 NAD binding site [chemical binding]; other site 1034809002186 catalytic site [active] 1034809002191 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1034809002192 dimer interface [polypeptide binding]; other site 1034809002193 FMN binding site [chemical binding]; other site 1034809002195 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1034809002196 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1034809002199 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1034809002200 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1034809002201 NAD(P) binding site [chemical binding]; other site 1034809002202 catalytic residues [active] 1034809002206 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1034809002207 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1034809002208 putative metal binding site [ion binding]; other site 1034809002209 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1034809002210 active site 1034809002213 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1034809002214 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1034809002218 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034809002219 MarR family; Region: MarR; pfam01047 1034809002221 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1034809002222 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034809002223 Zn binding site [ion binding]; other site 1034809002224 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1034809002225 Zn binding site [ion binding]; other site 1034809002228 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1034809002229 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034809002230 Zn binding site [ion binding]; other site 1034809002231 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1034809002232 Zn binding site [ion binding]; other site 1034809002234 Predicted esterase [General function prediction only]; Region: COG0400 1034809002236 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1034809002237 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1034809002238 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1034809002241 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1034809002243 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1034809002244 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1034809002246 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1034809002247 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1034809002248 ATP binding site [chemical binding]; other site 1034809002249 substrate interface [chemical binding]; other site 1034809002252 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1034809002253 ThiS interaction site; other site 1034809002254 putative active site [active] 1034809002255 tetramer interface [polypeptide binding]; other site 1034809002258 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1034809002259 thiS-thiF/thiG interaction site; other site 1034809002261 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1034809002262 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1034809002264 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1034809002265 thiamine phosphate binding site [chemical binding]; other site 1034809002266 active site 1034809002267 pyrophosphate binding site [ion binding]; other site 1034809002269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809002270 D-galactonate transporter; Region: 2A0114; TIGR00893 1034809002271 putative substrate translocation pore; other site 1034809002273 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1034809002275 Predicted membrane protein [Function unknown]; Region: COG1289 1034809002276 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1034809002278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1034809002280 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1034809002281 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1034809002282 synthetase active site [active] 1034809002283 NTP binding site [chemical binding]; other site 1034809002284 metal binding site [ion binding]; metal-binding site 1034809002286 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1034809002287 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1034809002289 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1034809002290 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1034809002291 DNA binding residues [nucleotide binding] 1034809002292 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1034809002293 predicted helix-turn-helix motif with score1749.000,SD 5.14 at aa 4-25 1034809002296 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1034809002297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034809002298 DNA-binding site [nucleotide binding]; DNA binding site 1034809002299 FCD domain; Region: FCD; pfam07729 1034809002302 predicted helix-turn-helix motif with score1606.000,SD 4.66 at aa 38-59 1034809002304 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1034809002305 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1034809002306 N- and C-terminal domain interface [polypeptide binding]; other site 1034809002307 active site 1034809002308 catalytic site [active] 1034809002309 metal binding site [ion binding]; metal-binding site 1034809002310 carbohydrate binding site [chemical binding]; other site 1034809002311 ATP binding site [chemical binding]; other site 1034809002315 GntP family permease; Region: GntP_permease; pfam02447 1034809002316 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1034809002318 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1034809002319 active site 1034809002320 tetramer interface; other site 1034809002325 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1034809002326 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1034809002327 active site 1034809002328 substrate binding site [chemical binding]; other site 1034809002329 metal binding site [ion binding]; metal-binding site 1034809002334 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1034809002335 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1034809002338 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1034809002339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1034809002340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809002341 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034809002344 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1034809002345 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1034809002346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809002347 NAD(P) binding site [chemical binding]; other site 1034809002348 active site 1034809002350 acetylornithine deacetylase; Validated; Region: PRK08596 1034809002351 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1034809002352 metal binding site [ion binding]; metal-binding site 1034809002355 polyphosphate kinase; Provisional; Region: PRK05443 1034809002356 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1034809002357 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1034809002358 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1034809002359 putative domain interface [polypeptide binding]; other site 1034809002360 putative active site [active] 1034809002361 catalytic site [active] 1034809002362 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1034809002363 putative domain interface [polypeptide binding]; other site 1034809002364 putative active site [active] 1034809002365 catalytic site [active] 1034809002367 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1034809002368 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1034809002369 nucleotide binding site [chemical binding]; other site 1034809002371 AbgT putative transporter family; Region: ABG_transport; pfam03806 1034809002372 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1034809002375 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1034809002376 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1034809002377 oligomer interface [polypeptide binding]; other site 1034809002378 active site 1034809002379 metal binding site [ion binding]; metal-binding site 1034809002381 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 1034809002384 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1034809002385 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1034809002386 homodimer interface [polypeptide binding]; other site 1034809002387 substrate-cofactor binding pocket; other site 1034809002388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809002389 catalytic residue [active] 1034809002392 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1034809002393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809002394 dimer interface [polypeptide binding]; other site 1034809002395 conserved gate region; other site 1034809002396 ABC-ATPase subunit interface; other site 1034809002398 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1034809002399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809002400 dimer interface [polypeptide binding]; other site 1034809002401 conserved gate region; other site 1034809002402 ABC-ATPase subunit interface; other site 1034809002404 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1034809002405 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1034809002406 Walker A/P-loop; other site 1034809002407 ATP binding site [chemical binding]; other site 1034809002408 Q-loop/lid; other site 1034809002409 ABC transporter signature motif; other site 1034809002410 Walker B; other site 1034809002411 D-loop; other site 1034809002412 H-loop/switch region; other site 1034809002416 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1034809002417 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034809002418 membrane-bound complex binding site; other site 1034809002421 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1034809002422 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1034809002423 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1034809002424 active site 1034809002425 metal binding site [ion binding]; metal-binding site 1034809002426 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1034809002430 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1034809002431 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1034809002432 active site 1034809002433 FMN binding site [chemical binding]; other site 1034809002434 substrate binding site [chemical binding]; other site 1034809002435 3Fe-4S cluster binding site [ion binding]; other site 1034809002438 CAAX protease self-immunity; Region: Abi; pfam02517 1034809002441 CAAX protease self-immunity; Region: Abi; pfam02517 1034809002443 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1034809002444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809002445 Walker A/P-loop; other site 1034809002446 ATP binding site [chemical binding]; other site 1034809002447 Q-loop/lid; other site 1034809002448 ABC transporter signature motif; other site 1034809002449 Walker B; other site 1034809002450 D-loop; other site 1034809002451 H-loop/switch region; other site 1034809002455 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1034809002457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034809002458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809002459 dimer interface [polypeptide binding]; other site 1034809002460 phosphorylation site [posttranslational modification] 1034809002461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809002462 ATP binding site [chemical binding]; other site 1034809002463 Mg2+ binding site [ion binding]; other site 1034809002464 G-X-G motif; other site 1034809002467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809002468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809002469 active site 1034809002470 phosphorylation site [posttranslational modification] 1034809002471 intermolecular recognition site; other site 1034809002472 dimerization interface [polypeptide binding]; other site 1034809002473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809002474 DNA binding site [nucleotide binding] 1034809002478 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034809002479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809002480 putative substrate translocation pore; other site 1034809002482 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1034809002483 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1034809002484 substrate binding pocket [chemical binding]; other site 1034809002485 catalytic triad [active] 1034809002489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1034809002490 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1034809002491 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1034809002493 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1034809002494 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1034809002495 putative NAD(P) binding site [chemical binding]; other site 1034809002496 catalytic Zn binding site [ion binding]; other site 1034809002500 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1034809002501 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1034809002502 Walker A/P-loop; other site 1034809002503 ATP binding site [chemical binding]; other site 1034809002504 Q-loop/lid; other site 1034809002505 ABC transporter signature motif; other site 1034809002506 Walker B; other site 1034809002507 D-loop; other site 1034809002508 H-loop/switch region; other site 1034809002509 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1034809002510 FOG: CBS domain [General function prediction only]; Region: COG0517 1034809002515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809002516 dimer interface [polypeptide binding]; other site 1034809002517 conserved gate region; other site 1034809002518 putative PBP binding loops; other site 1034809002519 ABC-ATPase subunit interface; other site 1034809002522 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1034809002523 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1034809002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809002527 dimer interface [polypeptide binding]; other site 1034809002528 conserved gate region; other site 1034809002529 ABC-ATPase subunit interface; other site 1034809002531 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1034809002532 LXG domain of WXG superfamily; Region: LXG; pfam04740 1034809002533 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1034809002535 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1034809002537 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1034809002538 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1034809002542 antiholin-like protein LrgB; Provisional; Region: PRK04288 1034809002544 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1034809002546 two-component response regulator; Provisional; Region: PRK14084 1034809002547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809002548 active site 1034809002549 phosphorylation site [posttranslational modification] 1034809002550 intermolecular recognition site; other site 1034809002551 dimerization interface [polypeptide binding]; other site 1034809002552 LytTr DNA-binding domain; Region: LytTR; pfam04397 1034809002555 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1034809002556 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1034809002557 GAF domain; Region: GAF; cl17456 1034809002558 Histidine kinase; Region: His_kinase; pfam06580 1034809002559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809002560 ATP binding site [chemical binding]; other site 1034809002561 Mg2+ binding site [ion binding]; other site 1034809002562 G-X-G motif; other site 1034809002566 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1034809002567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809002568 putative substrate translocation pore; other site 1034809002570 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1034809002571 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1034809002572 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1034809002575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1034809002576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809002577 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1034809002578 NAD(P) binding site [chemical binding]; other site 1034809002579 active site 1034809002581 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1034809002585 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1034809002586 Beta-lactamase; Region: Beta-lactamase; pfam00144 1034809002587 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 1034809002589 Amino acid permease; Region: AA_permease_2; pfam13520 1034809002593 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1034809002596 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1034809002598 putative phosphoesterase; Region: acc_ester; TIGR03729 1034809002599 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1034809002601 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1034809002602 putative active site [active] 1034809002604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1034809002606 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1034809002607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809002608 putative substrate translocation pore; other site 1034809002610 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1034809002613 Predicted membrane protein [Function unknown]; Region: COG2246 1034809002614 GtrA-like protein; Region: GtrA; pfam04138 1034809002616 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1034809002617 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1034809002619 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1034809002620 catalytic core [active] 1034809002621 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1034809002624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809002625 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809002626 putative substrate translocation pore; other site 1034809002629 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1034809002630 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034809002631 substrate binding pocket [chemical binding]; other site 1034809002632 membrane-bound complex binding site; other site 1034809002633 hinge residues; other site 1034809002636 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1034809002637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809002638 dimer interface [polypeptide binding]; other site 1034809002639 conserved gate region; other site 1034809002640 putative PBP binding loops; other site 1034809002641 ABC-ATPase subunit interface; other site 1034809002644 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1034809002645 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1034809002646 Walker A/P-loop; other site 1034809002647 ATP binding site [chemical binding]; other site 1034809002648 Q-loop/lid; other site 1034809002649 ABC transporter signature motif; other site 1034809002650 Walker B; other site 1034809002651 D-loop; other site 1034809002652 H-loop/switch region; other site 1034809002656 FemAB family; Region: FemAB; pfam02388 1034809002657 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1034809002661 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1034809002662 Thioredoxin; Region: Thioredoxin_4; cl17273 1034809002664 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1034809002665 putative hydrophobic ligand binding site [chemical binding]; other site 1034809002667 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1034809002668 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1034809002669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809002670 Walker A/P-loop; other site 1034809002671 ATP binding site [chemical binding]; other site 1034809002672 Q-loop/lid; other site 1034809002673 ABC transporter signature motif; other site 1034809002674 Walker B; other site 1034809002675 D-loop; other site 1034809002676 H-loop/switch region; other site 1034809002680 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1034809002681 putative active site [active] 1034809002684 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1034809002687 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1034809002688 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1034809002689 putative active site [active] 1034809002690 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1034809002691 active site 1034809002693 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1034809002694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1034809002695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809002696 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1034809002697 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1034809002698 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1034809002701 predicted helix-turn-helix motif with score1031.000,SD 2.70 at aa 64-85 1034809002706 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1034809002707 [2Fe-2S] cluster binding site [ion binding]; other site 1034809002709 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1034809002710 active site 1034809002711 SAM binding site [chemical binding]; other site 1034809002712 homodimer interface [polypeptide binding]; other site 1034809002715 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1034809002716 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1034809002717 [4Fe-4S] binding site [ion binding]; other site 1034809002718 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1034809002719 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1034809002720 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1034809002721 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1034809002722 molybdopterin cofactor binding site; other site 1034809002728 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1034809002729 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1034809002731 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1034809002735 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1034809002736 GAF domain; Region: GAF; pfam01590 1034809002737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1034809002738 Histidine kinase; Region: HisKA_3; pfam07730 1034809002739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809002740 ATP binding site [chemical binding]; other site 1034809002741 Mg2+ binding site [ion binding]; other site 1034809002742 G-X-G motif; other site 1034809002745 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034809002746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809002747 active site 1034809002748 phosphorylation site [posttranslational modification] 1034809002749 intermolecular recognition site; other site 1034809002750 dimerization interface [polypeptide binding]; other site 1034809002751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034809002752 DNA binding residues [nucleotide binding] 1034809002753 dimerization interface [polypeptide binding]; other site 1034809002757 predicted helix-turn-helix motif with score1054.000,SD 2.78 at aa 170-191 1034809002758 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1034809002759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809002760 putative substrate translocation pore; other site 1034809002762 MarR family; Region: MarR_2; cl17246 1034809002764 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1034809002765 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1034809002766 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1034809002772 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1034809002774 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1034809002775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034809002779 predicted helix-turn-helix motif with score2030.000,SD 6.10 at aa 164-185 1034809002780 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1034809002782 predicted helix-turn-helix motif with score1074.000,SD 2.84 at aa 101-122 1034809002783 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1034809002784 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034809002785 active site turn [active] 1034809002786 phosphorylation site [posttranslational modification] 1034809002787 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1034809002791 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1034809002792 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1034809002793 Cl binding site [ion binding]; other site 1034809002794 oligomer interface [polypeptide binding]; other site 1034809002796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809002797 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1034809002799 predicted helix-turn-helix motif with score1262.000,SD 3.49 at aa 30-51 1034809002800 Predicted membrane protein [Function unknown]; Region: COG1511 1034809002801 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1034809002802 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1034809002804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034809002805 MarR family; Region: MarR_2; pfam12802 1034809002807 predicted helix-turn-helix motif with score1067.000,SD 2.82 at aa 48-69 1034809002808 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1034809002809 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1034809002812 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1034809002813 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034809002814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1034809002815 Walker A/P-loop; other site 1034809002816 ATP binding site [chemical binding]; other site 1034809002817 Q-loop/lid; other site 1034809002818 ABC transporter signature motif; other site 1034809002819 Walker B; other site 1034809002820 D-loop; other site 1034809002821 H-loop/switch region; other site 1034809002825 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1034809002826 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1034809002827 Walker A/P-loop; other site 1034809002828 ATP binding site [chemical binding]; other site 1034809002829 Q-loop/lid; other site 1034809002830 ABC transporter signature motif; other site 1034809002831 Walker B; other site 1034809002832 D-loop; other site 1034809002833 H-loop/switch region; other site 1034809002834 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034809002839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809002840 putative PBP binding loops; other site 1034809002841 ABC-ATPase subunit interface; other site 1034809002844 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1034809002845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809002846 dimer interface [polypeptide binding]; other site 1034809002847 conserved gate region; other site 1034809002848 putative PBP binding loops; other site 1034809002849 ABC-ATPase subunit interface; other site 1034809002851 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1034809002852 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1034809002855 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1034809002857 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1034809002860 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1034809002861 UreF; Region: UreF; pfam01730 1034809002863 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1034809002864 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1034809002865 dimer interface [polypeptide binding]; other site 1034809002866 catalytic residues [active] 1034809002869 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1034809002870 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1034809002871 subunit interactions [polypeptide binding]; other site 1034809002872 active site 1034809002873 flap region; other site 1034809002879 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1034809002880 gamma-beta subunit interface [polypeptide binding]; other site 1034809002881 alpha-beta subunit interface [polypeptide binding]; other site 1034809002883 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1034809002884 alpha-gamma subunit interface [polypeptide binding]; other site 1034809002885 beta-gamma subunit interface [polypeptide binding]; other site 1034809002887 Urea transporter; Region: UT; cl01829 1034809002890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034809002891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809002893 predicted helix-turn-helix motif with score1944.000,SD 5.81 at aa 31-52 1034809002894 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1034809002897 ThiC-associated domain; Region: ThiC-associated; pfam13667 1034809002898 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1034809002899 ThiC family; Region: ThiC; pfam01964 1034809002901 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1034809002904 tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218 1034809002906 Integral membrane protein DUF95; Region: DUF95; pfam01944 1034809002908 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1034809002909 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809002910 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809002911 ABC transporter; Region: ABC_tran_2; pfam12848 1034809002912 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809002918 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1034809002920 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1034809002921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809002923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034809002924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1034809002925 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034809002926 dimerization interface [polypeptide binding]; other site 1034809002928 predicted helix-turn-helix motif with score1384.000,SD 3.90 at aa 16-37 1034809002930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809002931 Coenzyme A binding pocket [chemical binding]; other site 1034809002933 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034809002934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809002935 non-specific DNA binding site [nucleotide binding]; other site 1034809002936 salt bridge; other site 1034809002937 sequence-specific DNA binding site [nucleotide binding]; other site 1034809002939 predicted helix-turn-helix motif with score1957.000,SD 5.85 at aa 15-36 1034809002940 CAAX protease self-immunity; Region: Abi; pfam02517 1034809002942 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1034809002943 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1034809002944 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1034809002949 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1034809002950 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1034809002951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809002952 S-adenosylmethionine binding site [chemical binding]; other site 1034809002953 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1034809002956 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1034809002957 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1034809002958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034809002959 ATP binding site [chemical binding]; other site 1034809002960 putative Mg++ binding site [ion binding]; other site 1034809002963 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034809002964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809002965 non-specific DNA binding site [nucleotide binding]; other site 1034809002966 salt bridge; other site 1034809002967 sequence-specific DNA binding site [nucleotide binding]; other site 1034809002969 predicted helix-turn-helix motif with score2276.000,SD 6.94 at aa 16-37 1034809002970 CAAX protease self-immunity; Region: Abi; pfam02517 1034809002973 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034809002974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809002975 non-specific DNA binding site [nucleotide binding]; other site 1034809002976 salt bridge; other site 1034809002977 sequence-specific DNA binding site [nucleotide binding]; other site 1034809002978 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1034809002980 predicted helix-turn-helix motif with score2556.000,SD 7.89 at aa 19-40 1034809002982 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1034809002983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1034809002984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809002988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809002989 Coenzyme A binding pocket [chemical binding]; other site 1034809002990 Poxvirus proteins of unknown function; Region: DUF230; cl17785 1034809002992 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1034809002993 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1034809002994 NAD(P) binding site [chemical binding]; other site 1034809002997 Imelysin; Region: Peptidase_M75; pfam09375 1034809003001 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1034809003002 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1034809003005 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1034809003006 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1034809003008 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1034809003010 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1034809003011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809003012 Coenzyme A binding pocket [chemical binding]; other site 1034809003015 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1034809003017 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1034809003018 L-lactate permease; Region: Lactate_perm; cl00701 1034809003020 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034809003021 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1034809003022 putative ADP-binding pocket [chemical binding]; other site 1034809003024 malate:quinone oxidoreductase; Validated; Region: PRK05257 1034809003025 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1034809003027 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1034809003028 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1034809003029 LytTr DNA-binding domain; Region: LytTR; smart00850 1034809003031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034809003032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034809003033 dimerization interface [polypeptide binding]; other site 1034809003034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809003035 dimer interface [polypeptide binding]; other site 1034809003036 phosphorylation site [posttranslational modification] 1034809003037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809003038 ATP binding site [chemical binding]; other site 1034809003039 Mg2+ binding site [ion binding]; other site 1034809003040 G-X-G motif; other site 1034809003044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809003045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809003046 active site 1034809003047 phosphorylation site [posttranslational modification] 1034809003048 intermolecular recognition site; other site 1034809003049 dimerization interface [polypeptide binding]; other site 1034809003050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809003051 DNA binding site [nucleotide binding] 1034809003054 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1034809003055 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1034809003056 FtsX-like permease family; Region: FtsX; pfam02687 1034809003058 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1034809003059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034809003060 Walker A/P-loop; other site 1034809003061 ATP binding site [chemical binding]; other site 1034809003062 Q-loop/lid; other site 1034809003063 ABC transporter signature motif; other site 1034809003064 Walker B; other site 1034809003065 D-loop; other site 1034809003066 H-loop/switch region; other site 1034809003069 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1034809003070 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1034809003071 putative active site [active] 1034809003073 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034809003074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034809003075 putative DNA binding site [nucleotide binding]; other site 1034809003076 putative Zn2+ binding site [ion binding]; other site 1034809003078 predicted helix-turn-helix motif with score1707.000,SD 5.00 at aa 53-74 1034809003079 Predicted membrane protein [Function unknown]; Region: COG4640 1034809003080 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1034809003081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809003082 putative substrate translocation pore; other site 1034809003085 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1034809003086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809003088 predicted helix-turn-helix motif with score1036.000,SD 2.72 at aa 25-46 1034809003089 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1034809003090 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1034809003091 E3 interaction surface; other site 1034809003092 lipoyl attachment site [posttranslational modification]; other site 1034809003093 HlyD family secretion protein; Region: HlyD_3; pfam13437 1034809003094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809003095 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1034809003096 putative substrate translocation pore; other site 1034809003098 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1034809003099 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1034809003101 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1034809003102 active site 1034809003103 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1034809003104 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1034809003105 oligomer interface [polypeptide binding]; other site 1034809003106 metal binding site [ion binding]; metal-binding site 1034809003107 metal binding site [ion binding]; metal-binding site 1034809003108 putative Cl binding site [ion binding]; other site 1034809003109 aspartate ring; other site 1034809003110 basic sphincter; other site 1034809003111 hydrophobic gate; other site 1034809003112 periplasmic entrance; other site 1034809003114 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1034809003115 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1034809003116 homotetramer interface [polypeptide binding]; other site 1034809003117 FMN binding site [chemical binding]; other site 1034809003118 homodimer contacts [polypeptide binding]; other site 1034809003119 putative active site [active] 1034809003120 putative substrate binding site [chemical binding]; other site 1034809003122 predicted helix-turn-helix motif with score1204.000,SD 3.29 at aa 271-292 1034809003123 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1034809003124 active site 1034809003125 DNA binding site [nucleotide binding] 1034809003127 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034809003128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809003129 non-specific DNA binding site [nucleotide binding]; other site 1034809003130 salt bridge; other site 1034809003131 sequence-specific DNA binding site [nucleotide binding]; other site 1034809003133 predicted helix-turn-helix motif with score2094.000,SD 6.32 at aa 20-41 1034809003134 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1034809003135 active site 1034809003136 catalytic residues [active] 1034809003139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1034809003140 MOSC domain; Region: MOSC; pfam03473 1034809003141 3-alpha domain; Region: 3-alpha; pfam03475 1034809003144 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1034809003145 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034809003146 active site 1034809003147 dimer interface [polypeptide binding]; other site 1034809003149 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1034809003151 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1034809003152 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1034809003153 metal binding site [ion binding]; metal-binding site 1034809003156 oxidoreductase; Provisional; Region: PRK07985 1034809003157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809003158 NAD(P) binding site [chemical binding]; other site 1034809003159 active site 1034809003163 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1034809003165 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1034809003166 putative hydrophobic ligand binding site [chemical binding]; other site 1034809003168 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1034809003169 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1034809003170 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1034809003171 putative active site [active] 1034809003174 predicted helix-turn-helix motif with score1209.000,SD 3.30 at aa 35-56 1034809003175 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1034809003176 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1034809003177 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034809003178 active site turn [active] 1034809003179 phosphorylation site [posttranslational modification] 1034809003183 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1034809003184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809003185 active site 1034809003186 motif I; other site 1034809003187 motif II; other site 1034809003189 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1034809003193 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1034809003194 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1034809003195 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1034809003196 putative active site [active] 1034809003199 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1034809003200 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034809003201 active site turn [active] 1034809003202 phosphorylation site [posttranslational modification] 1034809003203 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1034809003206 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1034809003207 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1034809003208 putative active site [active] 1034809003211 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1034809003212 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1034809003214 Predicted transcriptional regulator [Transcription]; Region: COG2378 1034809003215 HTH domain; Region: HTH_11; pfam08279 1034809003217 predicted helix-turn-helix motif with score2031.000,SD 6.10 at aa 20-41 1034809003218 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1034809003219 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1034809003220 active site 1034809003222 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1034809003224 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1034809003225 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1034809003226 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1034809003227 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1034809003228 4Fe-4S binding domain; Region: Fer4; pfam00037 1034809003229 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1034809003230 [4Fe-4S] binding site [ion binding]; other site 1034809003231 molybdopterin cofactor binding site; other site 1034809003232 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1034809003233 molybdopterin cofactor binding site; other site 1034809003243 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1034809003245 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1034809003246 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1034809003249 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1034809003250 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1034809003251 putative ligand binding site [chemical binding]; other site 1034809003252 putative NAD binding site [chemical binding]; other site 1034809003253 catalytic site [active] 1034809003258 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1034809003261 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1034809003263 CHAP domain; Region: CHAP; pfam05257 1034809003264 Surface antigen [General function prediction only]; Region: COG3942 1034809003266 Tic20-like protein; Region: Tic20; pfam09685 1034809003267 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1034809003268 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1034809003271 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1034809003273 Surface antigen [General function prediction only]; Region: COG3942 1034809003274 CHAP domain; Region: CHAP; pfam05257 1034809003276 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1034809003277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034809003278 predicted helix-turn-helix motif with score1510.000,SD 4.33 at aa 165-186 1034809003281 MarR family; Region: MarR_2; cl17246 1034809003282 MarR family; Region: MarR_2; cl17246 1034809003284 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1034809003285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809003286 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1034809003287 Walker A motif; other site 1034809003288 ATP binding site [chemical binding]; other site 1034809003289 Walker B motif; other site 1034809003290 arginine finger; other site 1034809003291 UvrB/uvrC motif; Region: UVR; pfam02151 1034809003292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809003293 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1034809003294 Walker A motif; other site 1034809003295 ATP binding site [chemical binding]; other site 1034809003296 Walker B motif; other site 1034809003297 arginine finger; other site 1034809003298 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1034809003305 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1034809003306 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1034809003307 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1034809003310 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1034809003311 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1034809003312 intersubunit interface [polypeptide binding]; other site 1034809003315 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1034809003316 active site 1034809003317 dimerization interface [polypeptide binding]; other site 1034809003319 predicted helix-turn-helix motif with score1141.000,SD 3.07 at aa 128-149 1034809003320 BioY family; Region: BioY; pfam02632 1034809003322 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1034809003323 Coenzyme A binding pocket [chemical binding]; other site 1034809003325 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1034809003327 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1034809003328 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1034809003331 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1034809003332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809003333 dimer interface [polypeptide binding]; other site 1034809003334 conserved gate region; other site 1034809003335 putative PBP binding loops; other site 1034809003336 ABC-ATPase subunit interface; other site 1034809003338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809003339 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034809003340 Walker A/P-loop; other site 1034809003341 ATP binding site [chemical binding]; other site 1034809003342 Q-loop/lid; other site 1034809003343 ABC transporter signature motif; other site 1034809003344 Walker B; other site 1034809003345 D-loop; other site 1034809003346 H-loop/switch region; other site 1034809003350 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1034809003351 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1034809003352 ATP binding site [chemical binding]; other site 1034809003353 substrate interface [chemical binding]; other site 1034809003357 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1034809003358 MPT binding site; other site 1034809003359 trimer interface [polypeptide binding]; other site 1034809003362 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1034809003363 trimer interface [polypeptide binding]; other site 1034809003364 dimer interface [polypeptide binding]; other site 1034809003365 putative active site [active] 1034809003367 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1034809003368 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1034809003369 dimer interface [polypeptide binding]; other site 1034809003370 putative functional site; other site 1034809003371 putative MPT binding site; other site 1034809003376 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1034809003379 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1034809003380 MoaE homodimer interface [polypeptide binding]; other site 1034809003381 MoaD interaction [polypeptide binding]; other site 1034809003382 active site residues [active] 1034809003384 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1034809003385 MoaE interaction surface [polypeptide binding]; other site 1034809003386 MoeB interaction surface [polypeptide binding]; other site 1034809003387 thiocarboxylated glycine; other site 1034809003389 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1034809003390 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1034809003391 GTP binding site; other site 1034809003392 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1034809003393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034809003394 FeS/SAM binding site; other site 1034809003395 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1034809003399 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1034809003400 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1034809003401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809003402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809003403 putative substrate translocation pore; other site 1034809003406 MarR family; Region: MarR_2; cl17246 1034809003407 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034809003409 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1034809003410 FemAB family; Region: FemAB; pfam02388 1034809003411 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1034809003414 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1034809003415 Protein export membrane protein; Region: SecD_SecF; cl14618 1034809003417 Predicted permeases [General function prediction only]; Region: COG0679 1034809003419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809003420 Coenzyme A binding pocket [chemical binding]; other site 1034809003422 DNA topoisomerase III; Provisional; Region: PRK07726 1034809003423 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1034809003424 active site 1034809003425 putative interdomain interaction site [polypeptide binding]; other site 1034809003426 putative metal-binding site [ion binding]; other site 1034809003427 putative nucleotide binding site [chemical binding]; other site 1034809003428 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1034809003429 domain I; other site 1034809003430 DNA binding groove [nucleotide binding] 1034809003431 phosphate binding site [ion binding]; other site 1034809003432 domain II; other site 1034809003433 domain III; other site 1034809003434 nucleotide binding site [chemical binding]; other site 1034809003435 catalytic site [active] 1034809003436 domain IV; other site 1034809003437 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1034809003441 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1034809003445 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1034809003448 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1034809003451 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1034809003453 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1034809003455 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1034809003456 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1034809003457 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1034809003461 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1034809003464 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1034809003465 putative translocon binding site; other site 1034809003466 protein-rRNA interface [nucleotide binding]; other site 1034809003469 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1034809003470 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1034809003471 G-X-X-G motif; other site 1034809003472 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1034809003477 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1034809003478 23S rRNA interface [nucleotide binding]; other site 1034809003479 5S rRNA interface [nucleotide binding]; other site 1034809003480 putative antibiotic binding site [chemical binding]; other site 1034809003481 L25 interface [polypeptide binding]; other site 1034809003482 L27 interface [polypeptide binding]; other site 1034809003486 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1034809003487 23S rRNA interface [nucleotide binding]; other site 1034809003488 putative translocon interaction site; other site 1034809003489 signal recognition particle (SRP54) interaction site; other site 1034809003490 L23 interface [polypeptide binding]; other site 1034809003491 trigger factor interaction site; other site 1034809003493 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1034809003496 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1034809003499 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1034809003500 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1034809003501 RNA binding site [nucleotide binding]; other site 1034809003504 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1034809003505 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1034809003506 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1034809003510 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1034809003513 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1034809003517 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1034809003518 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1034809003519 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1034809003523 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1034809003524 5S rRNA interface [nucleotide binding]; other site 1034809003525 L27 interface [polypeptide binding]; other site 1034809003526 23S rRNA interface [nucleotide binding]; other site 1034809003527 L5 interface [polypeptide binding]; other site 1034809003529 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1034809003530 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1034809003531 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1034809003535 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1034809003536 23S rRNA binding site [nucleotide binding]; other site 1034809003538 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1034809003543 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1034809003544 SecY translocase; Region: SecY; pfam00344 1034809003549 adenylate kinase; Reviewed; Region: adk; PRK00279 1034809003550 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1034809003551 AMP-binding site [chemical binding]; other site 1034809003552 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1034809003556 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1034809003557 rRNA binding site [nucleotide binding]; other site 1034809003558 predicted 30S ribosome binding site; other site 1034809003560 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1034809003563 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1034809003564 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1034809003567 30S ribosomal protein S11; Validated; Region: PRK05309 1034809003570 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1034809003571 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1034809003572 alphaNTD homodimer interface [polypeptide binding]; other site 1034809003573 alphaNTD - beta interaction site [polypeptide binding]; other site 1034809003574 alphaNTD - beta' interaction site [polypeptide binding]; other site 1034809003575 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1034809003579 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1034809003582 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1034809003583 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1034809003584 Walker A/P-loop; other site 1034809003585 ATP binding site [chemical binding]; other site 1034809003586 Q-loop/lid; other site 1034809003587 ABC transporter signature motif; other site 1034809003588 Walker B; other site 1034809003589 D-loop; other site 1034809003590 H-loop/switch region; other site 1034809003594 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1034809003595 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1034809003596 Walker A/P-loop; other site 1034809003597 ATP binding site [chemical binding]; other site 1034809003598 Q-loop/lid; other site 1034809003599 ABC transporter signature motif; other site 1034809003600 Walker B; other site 1034809003601 D-loop; other site 1034809003602 H-loop/switch region; other site 1034809003606 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1034809003608 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1034809003609 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1034809003610 dimerization interface 3.5A [polypeptide binding]; other site 1034809003611 active site 1034809003615 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1034809003616 23S rRNA interface [nucleotide binding]; other site 1034809003617 L3 interface [polypeptide binding]; other site 1034809003620 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1034809003623 hypothetical protein; Provisional; Region: PRK06474 1034809003624 dimerization interface [polypeptide binding]; other site 1034809003625 putative DNA binding site [nucleotide binding]; other site 1034809003626 putative Zn2+ binding site [ion binding]; other site 1034809003627 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1034809003628 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034809003629 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1034809003630 Walker A/P-loop; other site 1034809003631 ATP binding site [chemical binding]; other site 1034809003632 Q-loop/lid; other site 1034809003633 ABC transporter signature motif; other site 1034809003634 Walker B; other site 1034809003635 D-loop; other site 1034809003636 H-loop/switch region; other site 1034809003640 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1034809003641 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1034809003642 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1034809003643 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1034809003644 Walker A/P-loop; other site 1034809003645 ATP binding site [chemical binding]; other site 1034809003646 Q-loop/lid; other site 1034809003647 ABC transporter signature motif; other site 1034809003648 Walker B; other site 1034809003649 D-loop; other site 1034809003650 H-loop/switch region; other site 1034809003655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034809003656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1034809003658 Condensation domain; Region: Condensation; pfam00668 1034809003659 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1034809003660 AMP-binding enzyme; Region: AMP-binding; pfam00501 1034809003661 acyl-activating enzyme (AAE) consensus motif; other site 1034809003662 AMP binding site [chemical binding]; other site 1034809003663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809003664 Condensation domain; Region: Condensation; pfam00668 1034809003665 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1034809003666 Condensation domain; Region: Condensation; pfam00668 1034809003667 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034809003668 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1034809003669 acyl-activating enzyme (AAE) consensus motif; other site 1034809003670 AMP binding site [chemical binding]; other site 1034809003671 active site 1034809003672 CoA binding site [chemical binding]; other site 1034809003673 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809003680 predicted helix-turn-helix motif with score974.000,SD 2.50 at aa 1090-1111 1034809003688 Condensation domain; Region: Condensation; pfam00668 1034809003690 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1034809003691 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1034809003692 acyl-activating enzyme (AAE) consensus motif; other site 1034809003693 AMP binding site [chemical binding]; other site 1034809003694 active site 1034809003695 CoA binding site [chemical binding]; other site 1034809003696 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809003697 Condensation domain; Region: Condensation; pfam00668 1034809003701 Condensation domain; Region: Condensation; pfam00668 1034809003702 AMP-binding enzyme; Region: AMP-binding; pfam00501 1034809003703 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1034809003704 acyl-activating enzyme (AAE) consensus motif; other site 1034809003705 AMP binding site [chemical binding]; other site 1034809003706 active site 1034809003707 CoA binding site [chemical binding]; other site 1034809003708 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809003709 Condensation domain; Region: Condensation; pfam00668 1034809003710 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034809003711 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1034809003712 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809003713 Condensation domain; Region: Condensation; pfam00668 1034809003714 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034809003715 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809003716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809003717 NAD(P) binding site [chemical binding]; other site 1034809003718 active site 1034809003731 Thioesterase domain; Region: Thioesterase; pfam00975 1034809003733 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1034809003734 AMP-binding enzyme; Region: AMP-binding; pfam00501 1034809003735 acyl-activating enzyme (AAE) consensus motif; other site 1034809003736 AMP binding site [chemical binding]; other site 1034809003737 active site 1034809003738 CoA binding site [chemical binding]; other site 1034809003739 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809003743 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1034809003744 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1034809003745 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1034809003746 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1034809003749 NAD-dependent deacetylase; Provisional; Region: PRK00481 1034809003750 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1034809003752 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1034809003753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034809003754 DNA-binding site [nucleotide binding]; DNA binding site 1034809003755 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1034809003759 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1034809003761 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1034809003763 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1034809003764 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1034809003765 putative substrate binding site [chemical binding]; other site 1034809003766 putative ATP binding site [chemical binding]; other site 1034809003770 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1034809003772 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1034809003773 methionine cluster; other site 1034809003774 active site 1034809003775 phosphorylation site [posttranslational modification] 1034809003776 metal binding site [ion binding]; metal-binding site 1034809003778 CDS is disrupted by a phage insertion after residue 293 1034809003780 prophage ?SL1 1034809003781 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1034809003782 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1034809003783 catalytic residues [active] 1034809003784 catalytic nucleophile [active] 1034809003785 Presynaptic Site I dimer interface [polypeptide binding]; other site 1034809003786 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1034809003787 Synaptic Flat tetramer interface [polypeptide binding]; other site 1034809003788 Synaptic Site I dimer interface [polypeptide binding]; other site 1034809003789 DNA binding site [nucleotide binding] 1034809003790 Recombinase; Region: Recombinase; pfam07508 1034809003791 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1034809003795 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1034809003797 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034809003798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809003799 non-specific DNA binding site [nucleotide binding]; other site 1034809003800 salt bridge; other site 1034809003801 sequence-specific DNA binding site [nucleotide binding]; other site 1034809003803 predicted helix-turn-helix motif with score2347.000,SD 7.18 at aa 20-41 1034809003804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809003805 non-specific DNA binding site [nucleotide binding]; other site 1034809003806 salt bridge; other site 1034809003807 sequence-specific DNA binding site [nucleotide binding]; other site 1034809003809 predicted helix-turn-helix motif with score1919.000,SD 5.72 at aa 33-54 1034809003810 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 1034809003811 ORF6C domain; Region: ORF6C; pfam10552 1034809003812 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 1034809003813 Phage anti-repressor protein [Transcription]; Region: COG3561 1034809003814 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1034809003817 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1034809003818 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1034809003820 ERF superfamily; Region: ERF; pfam04404 1034809003822 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1034809003823 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1034809003824 dimer interface [polypeptide binding]; other site 1034809003825 ssDNA binding site [nucleotide binding]; other site 1034809003826 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034809003828 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1034809003830 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1034809003832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809003833 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1034809003834 Walker A motif; other site 1034809003835 ATP binding site [chemical binding]; other site 1034809003836 Walker B motif; other site 1034809003837 arginine finger; other site 1034809003839 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1034809003842 predicted helix-turn-helix motif with score1047.000,SD 2.75 at aa 62-83 1034809003843 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 1034809003844 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1034809003846 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1034809003847 trimer interface [polypeptide binding]; other site 1034809003848 active site 1034809003850 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1034809003853 predicted helix-turn-helix motif with score1290.000,SD 3.58 at aa 31-52 1034809003854 Phage terminase large subunit; Region: Terminase_3; cl12054 1034809003859 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1034809003860 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1034809003862 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1034809003864 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1034809003865 Phage capsid family; Region: Phage_capsid; pfam05065 1034809003866 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 1034809003868 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1034809003870 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1034809003872 Phage protein; Region: DUF3647; pfam12363 1034809003873 Phage-related protein [Function unknown]; Region: COG5412 1034809003874 Phage-related protein [Function unknown]; Region: COG5412 1034809003875 membrane protein P6; Region: PHA01399 1034809003877 Phage tail protein; Region: Sipho_tail; pfam05709 1034809003879 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1034809003880 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 1034809003881 active site 1034809003882 Zn binding site [ion binding]; other site 1034809003884 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1034809003886 CHAP domain; Region: CHAP; pfam05257 1034809003887 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1034809003888 Lysozyme subfamily 2; Region: LYZ2; smart00047 1034809003891 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1034809003892 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1034809003893 active site 1034809003894 oxyanion hole [active] 1034809003895 catalytic triad [active] 1034809003898 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1034809003900 CHAP domain; Region: CHAP; pfam05257 1034809003901 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1034809003902 active site 1034809003903 metal binding site [ion binding]; metal-binding site 1034809003904 Bacterial SH3 domain; Region: SH3_5; pfam08460 1034809003909 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1034809003910 beta-galactosidase; Region: BGL; TIGR03356 1034809003915 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1034809003918 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1034809003919 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1034809003920 NAD(P) binding site [chemical binding]; other site 1034809003921 substrate binding site [chemical binding]; other site 1034809003922 dimer interface [polypeptide binding]; other site 1034809003924 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1034809003925 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1034809003926 putative NAD(P) binding site [chemical binding]; other site 1034809003927 dimer interface [polypeptide binding]; other site 1034809003930 Small integral membrane protein [Function unknown]; Region: COG5547 1034809003932 Asp23 family; Region: Asp23; pfam03780 1034809003934 IucA / IucC family; Region: IucA_IucC; pfam04183 1034809003935 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1034809003937 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1034809003938 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1034809003939 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1034809003940 catalytic residue [active] 1034809003942 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1034809003943 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1034809003944 siderophore binding site; other site 1034809003947 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1034809003948 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809003949 ABC-ATPase subunit interface; other site 1034809003950 dimer interface [polypeptide binding]; other site 1034809003951 putative PBP binding regions; other site 1034809003953 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1034809003954 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809003955 ABC-ATPase subunit interface; other site 1034809003956 dimer interface [polypeptide binding]; other site 1034809003957 putative PBP binding regions; other site 1034809003959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1034809003960 Nucleoside recognition; Region: Gate; pfam07670 1034809003963 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1034809003966 CDS contains a frameshift after residue 205 1034809003968 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1034809003969 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1034809003971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809003972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809003973 putative substrate translocation pore; other site 1034809003974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809003976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809003977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809003978 putative substrate translocation pore; other site 1034809003981 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 1034809003982 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1034809003983 Walker A motif; other site 1034809003987 TIGR00159 family protein; Region: TIGR00159 1034809003988 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1034809003990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1034809003991 YbbR-like protein; Region: YbbR; pfam07949 1034809003992 YbbR-like protein; Region: YbbR; pfam07949 1034809003996 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1034809003997 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1034809003998 active site 1034809003999 substrate binding site [chemical binding]; other site 1034809004000 metal binding site [ion binding]; metal-binding site 1034809004006 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1034809004007 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1034809004008 glutaminase active site [active] 1034809004009 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1034809004010 dimer interface [polypeptide binding]; other site 1034809004011 active site 1034809004012 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1034809004013 dimer interface [polypeptide binding]; other site 1034809004014 active site 1034809004018 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1034809004019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809004020 active site 1034809004021 motif I; other site 1034809004022 motif II; other site 1034809004023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809004026 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1034809004027 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1034809004028 active site 1034809004029 metal binding site [ion binding]; metal-binding site 1034809004031 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1034809004032 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1034809004034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034809004035 dimerization interface [polypeptide binding]; other site 1034809004036 putative DNA binding site [nucleotide binding]; other site 1034809004037 putative Zn2+ binding site [ion binding]; other site 1034809004039 predicted helix-turn-helix motif with score1273.000,SD 3.52 at aa 38-59 1034809004040 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1034809004041 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1034809004042 NAD(P) binding site [chemical binding]; other site 1034809004043 putative active site [active] 1034809004045 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1034809004046 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1034809004050 EVE domain; Region: EVE; cl00728 1034809004051 Protein of unknown function, DUF393; Region: DUF393; cl01136 1034809004053 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1034809004054 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1034809004055 dimerization interface [polypeptide binding]; other site 1034809004056 DPS ferroxidase diiron center [ion binding]; other site 1034809004057 ion pore; other site 1034809004060 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1034809004061 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1034809004064 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1034809004065 intersubunit interface [polypeptide binding]; other site 1034809004066 active site 1034809004067 catalytic residue [active] 1034809004069 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1034809004070 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1034809004071 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1034809004072 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1034809004077 phosphopentomutase; Provisional; Region: PRK05362 1034809004078 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1034809004081 Predicted membrane protein [Function unknown]; Region: COG4270 1034809004082 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1034809004083 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1034809004084 G1 box; other site 1034809004085 GTP/Mg2+ binding site [chemical binding]; other site 1034809004086 Switch I region; other site 1034809004087 G2 box; other site 1034809004088 G3 box; other site 1034809004089 Switch II region; other site 1034809004090 G4 box; other site 1034809004091 G5 box; other site 1034809004092 Nucleoside recognition; Region: Gate; pfam07670 1034809004093 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1034809004094 Nucleoside recognition; Region: Gate; pfam07670 1034809004102 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1034809004104 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1034809004105 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1034809004106 metal binding site [ion binding]; metal-binding site 1034809004109 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1034809004110 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1034809004111 pantothenate kinase; Provisional; Region: PRK13317 1034809004112 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1034809004114 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1034809004115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809004116 Coenzyme A binding pocket [chemical binding]; other site 1034809004118 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1034809004120 CTP synthetase; Validated; Region: pyrG; PRK05380 1034809004121 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1034809004122 Catalytic site [active] 1034809004123 active site 1034809004124 UTP binding site [chemical binding]; other site 1034809004125 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1034809004126 active site 1034809004127 putative oxyanion hole; other site 1034809004128 catalytic triad [active] 1034809004132 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1034809004134 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1034809004135 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1034809004136 intersubunit interface [polypeptide binding]; other site 1034809004137 active site 1034809004138 zinc binding site [ion binding]; other site 1034809004139 Na+ binding site [ion binding]; other site 1034809004142 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1034809004143 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1034809004144 hinge; other site 1034809004145 active site 1034809004148 Predicted transcriptional regulators [Transcription]; Region: COG1733 1034809004149 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1034809004151 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1034809004152 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1034809004153 NAD binding site [chemical binding]; other site 1034809004154 catalytic residues [active] 1034809004158 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1034809004159 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1034809004160 RNA binding site [nucleotide binding]; other site 1034809004161 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1034809004162 multimer interface [polypeptide binding]; other site 1034809004163 Walker A motif; other site 1034809004164 ATP binding site [chemical binding]; other site 1034809004165 Walker B motif; other site 1034809004170 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1034809004173 thymidine kinase; Provisional; Region: PRK04296 1034809004177 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1034809004178 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1034809004179 RF-1 domain; Region: RF-1; pfam00472 1034809004183 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1034809004184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809004185 S-adenosylmethionine binding site [chemical binding]; other site 1034809004188 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1034809004189 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1034809004193 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1034809004194 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1034809004195 active site 1034809004197 hypothetical protein; Provisional; Region: PRK13690 1034809004199 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1034809004200 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1034809004201 dimer interface [polypeptide binding]; other site 1034809004202 active site 1034809004203 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1034809004204 folate binding site [chemical binding]; other site 1034809004207 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809004208 active site 1034809004212 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1034809004213 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1034809004216 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1034809004219 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1034809004220 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1034809004222 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1034809004223 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1034809004226 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1034809004227 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1034809004228 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1034809004229 beta subunit interaction interface [polypeptide binding]; other site 1034809004230 Walker A motif; other site 1034809004231 ATP binding site [chemical binding]; other site 1034809004232 Walker B motif; other site 1034809004233 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1034809004239 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1034809004240 core domain interface [polypeptide binding]; other site 1034809004241 delta subunit interface [polypeptide binding]; other site 1034809004242 epsilon subunit interface [polypeptide binding]; other site 1034809004244 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1034809004245 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1034809004246 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1034809004247 alpha subunit interaction interface [polypeptide binding]; other site 1034809004248 Walker A motif; other site 1034809004249 ATP binding site [chemical binding]; other site 1034809004250 Walker B motif; other site 1034809004251 inhibitor binding site; inhibition site 1034809004252 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1034809004258 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1034809004259 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1034809004260 gamma subunit interface [polypeptide binding]; other site 1034809004261 epsilon subunit interface [polypeptide binding]; other site 1034809004262 LBP interface [polypeptide binding]; other site 1034809004265 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1034809004267 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1034809004268 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1034809004269 hinge; other site 1034809004270 active site 1034809004273 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1034809004275 YwpF-like protein; Region: YwpF; pfam14183 1034809004276 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1034809004277 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1034809004278 dimer interface [polypeptide binding]; other site 1034809004279 ssDNA binding site [nucleotide binding]; other site 1034809004280 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034809004283 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1034809004284 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1034809004285 catalytic residue [active] 1034809004287 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1034809004289 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1034809004290 dimer interface [polypeptide binding]; other site 1034809004291 substrate binding site [chemical binding]; other site 1034809004292 ATP binding site [chemical binding]; other site 1034809004294 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1034809004295 substrate binding site [chemical binding]; other site 1034809004296 multimerization interface [polypeptide binding]; other site 1034809004297 ATP binding site [chemical binding]; other site 1034809004299 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1034809004300 thiamine phosphate binding site [chemical binding]; other site 1034809004301 active site 1034809004302 pyrophosphate binding site [ion binding]; other site 1034809004304 OxaA-like protein precursor; Provisional; Region: PRK02463 1034809004305 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1034809004308 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1034809004309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034809004310 Zn2+ binding site [ion binding]; other site 1034809004311 Mg2+ binding site [ion binding]; other site 1034809004313 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1034809004314 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1034809004315 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1034809004316 putative active site [active] 1034809004317 catalytic site [active] 1034809004318 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1034809004319 putative active site [active] 1034809004320 catalytic site [active] 1034809004323 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1034809004324 putative homodimer interface [polypeptide binding]; other site 1034809004325 putative homotetramer interface [polypeptide binding]; other site 1034809004326 allosteric switch controlling residues; other site 1034809004327 putative metal binding site [ion binding]; other site 1034809004328 putative homodimer-homodimer interface [polypeptide binding]; other site 1034809004330 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1034809004331 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1034809004336 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1034809004337 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1034809004338 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1034809004342 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1034809004343 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1034809004344 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034809004345 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034809004349 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1034809004350 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1034809004351 ATP binding site [chemical binding]; other site 1034809004352 Mg++ binding site [ion binding]; other site 1034809004353 motif III; other site 1034809004354 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034809004355 nucleotide binding region [chemical binding]; other site 1034809004356 ATP-binding site [chemical binding]; other site 1034809004361 Bacterial PH domain; Region: DUF304; cl01348 1034809004363 Predicted membrane protein [Function unknown]; Region: COG3428 1034809004364 Bacterial PH domain; Region: DUF304; pfam03703 1034809004365 Bacterial PH domain; Region: DUF304; pfam03703 1034809004368 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1034809004370 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1034809004372 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1034809004373 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1034809004374 active site 1034809004375 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1034809004376 dimer interface [polypeptide binding]; other site 1034809004377 substrate binding site [chemical binding]; other site 1034809004378 catalytic residues [active] 1034809004381 PemK-like protein; Region: PemK; pfam02452 1034809004383 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1034809004384 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1034809004385 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1034809004388 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1034809004389 anti sigma factor interaction site; other site 1034809004390 regulatory phosphorylation site [posttranslational modification]; other site 1034809004392 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1034809004393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809004394 ATP binding site [chemical binding]; other site 1034809004395 Mg2+ binding site [ion binding]; other site 1034809004396 G-X-G motif; other site 1034809004398 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1034809004399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034809004400 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1034809004401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034809004402 DNA binding residues [nucleotide binding] 1034809004407 predicted helix-turn-helix motif with score1939.000,SD 5.79 at aa 223-244 1034809004408 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1034809004409 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1034809004410 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1034809004411 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1034809004412 RNA binding site [nucleotide binding]; other site 1034809004415 hypothetical protein; Provisional; Region: PRK04351 1034809004416 SprT homologues; Region: SprT; cl01182 1034809004418 LysE type translocator; Region: LysE; cl00565 1034809004420 threonine dehydratase; Validated; Region: PRK08639 1034809004421 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1034809004422 tetramer interface [polypeptide binding]; other site 1034809004423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809004424 catalytic residue [active] 1034809004425 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1034809004426 putative Ile/Val binding site [chemical binding]; other site 1034809004430 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1034809004431 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1034809004432 substrate binding site [chemical binding]; other site 1034809004434 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1034809004435 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1034809004436 substrate binding site [chemical binding]; other site 1034809004437 ligand binding site [chemical binding]; other site 1034809004442 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1034809004443 tartrate dehydrogenase; Region: TTC; TIGR02089 1034809004447 2-isopropylmalate synthase; Validated; Region: PRK00915 1034809004448 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1034809004449 active site 1034809004450 catalytic residues [active] 1034809004451 metal binding site [ion binding]; metal-binding site 1034809004452 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1034809004455 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1034809004456 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1034809004457 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1034809004461 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1034809004462 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1034809004463 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1034809004464 PYR/PP interface [polypeptide binding]; other site 1034809004465 dimer interface [polypeptide binding]; other site 1034809004466 TPP binding site [chemical binding]; other site 1034809004467 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1034809004468 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1034809004469 TPP-binding site [chemical binding]; other site 1034809004470 dimer interface [polypeptide binding]; other site 1034809004475 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1034809004476 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1034809004480 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1034809004483 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1034809004484 Glycoprotease family; Region: Peptidase_M22; pfam00814 1034809004486 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1034809004487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809004488 Coenzyme A binding pocket [chemical binding]; other site 1034809004490 UGMP family protein; Validated; Region: PRK09604 1034809004491 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1034809004494 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1034809004495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809004496 Walker A/P-loop; other site 1034809004497 ATP binding site [chemical binding]; other site 1034809004498 Q-loop/lid; other site 1034809004499 ABC transporter signature motif; other site 1034809004500 Walker B; other site 1034809004501 D-loop; other site 1034809004502 H-loop/switch region; other site 1034809004505 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1034809004506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809004507 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809004508 ABC transporter; Region: ABC_tran_2; pfam12848 1034809004509 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809004516 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1034809004517 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1034809004518 CoA binding domain; Region: CoA_binding; pfam02629 1034809004521 Predicted transporter component [General function prediction only]; Region: COG2391 1034809004522 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1034809004527 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1034809004528 CPxP motif; other site 1034809004530 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1034809004532 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034809004533 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034809004534 DNA binding site [nucleotide binding] 1034809004535 domain linker motif; other site 1034809004536 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1034809004538 predicted helix-turn-helix motif with score2503.000,SD 7.71 at aa 2-23 1034809004541 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1034809004542 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1034809004543 substrate binding [chemical binding]; other site 1034809004544 active site 1034809004545 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1034809004550 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1034809004551 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1034809004552 putative substrate binding site [chemical binding]; other site 1034809004553 putative ATP binding site [chemical binding]; other site 1034809004557 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1034809004558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809004559 active site 1034809004560 phosphorylation site [posttranslational modification] 1034809004561 intermolecular recognition site; other site 1034809004562 dimerization interface [polypeptide binding]; other site 1034809004563 LytTr DNA-binding domain; Region: LytTR; pfam04397 1034809004566 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1034809004567 ATP binding site [chemical binding]; other site 1034809004568 Mg2+ binding site [ion binding]; other site 1034809004569 G-X-G motif; other site 1034809004571 Staphylococcal AgrD protein; Region: AgrD; pfam05931 1034809004573 Accessory gene regulator B; Region: AgrB; smart00793 1034809004575 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1034809004576 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1034809004577 putative active site [active] 1034809004578 catalytic triad [active] 1034809004579 putative dimer interface [polypeptide binding]; other site 1034809004583 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1034809004584 dimer interface [polypeptide binding]; other site 1034809004585 FMN binding site [chemical binding]; other site 1034809004587 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1034809004588 CAAX protease self-immunity; Region: Abi; pfam02517 1034809004590 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1034809004591 oligomerisation interface [polypeptide binding]; other site 1034809004592 mobile loop; other site 1034809004593 roof hairpin; other site 1034809004596 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1034809004597 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1034809004598 ring oligomerisation interface [polypeptide binding]; other site 1034809004599 ATP/Mg binding site [chemical binding]; other site 1034809004600 stacking interactions; other site 1034809004601 hinge regions; other site 1034809004605 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1034809004606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034809004607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809004608 homodimer interface [polypeptide binding]; other site 1034809004609 catalytic residue [active] 1034809004611 Predicted transcriptional regulators [Transcription]; Region: COG1725 1034809004612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034809004613 DNA-binding site [nucleotide binding]; DNA binding site 1034809004615 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034809004616 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1034809004617 Walker A/P-loop; other site 1034809004618 ATP binding site [chemical binding]; other site 1034809004619 Q-loop/lid; other site 1034809004620 ABC transporter signature motif; other site 1034809004621 Walker B; other site 1034809004622 D-loop; other site 1034809004623 H-loop/switch region; other site 1034809004627 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1034809004629 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034809004630 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1034809004631 Walker A/P-loop; other site 1034809004632 ATP binding site [chemical binding]; other site 1034809004633 Q-loop/lid; other site 1034809004634 ABC transporter signature motif; other site 1034809004635 Walker B; other site 1034809004636 D-loop; other site 1034809004637 H-loop/switch region; other site 1034809004638 KIF-1 binding protein C terminal; Region: KBP_C; pfam12309 1034809004641 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034809004642 catalytic residues [active] 1034809004643 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1034809004647 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1034809004648 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1034809004649 active site 1034809004650 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1034809004652 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1034809004654 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1034809004655 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1034809004656 NAD(P) binding site [chemical binding]; other site 1034809004657 catalytic residues [active] 1034809004661 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1034809004662 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1034809004663 DHHA2 domain; Region: DHHA2; pfam02833 1034809004666 Isochorismatase family; Region: Isochorismatase; pfam00857 1034809004667 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1034809004668 catalytic triad [active] 1034809004669 conserved cis-peptide bond; other site 1034809004671 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1034809004672 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1034809004673 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1034809004674 transmembrane helices; other site 1034809004676 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1034809004677 Prephenate dehydratase; Region: PDT; pfam00800 1034809004678 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1034809004679 putative L-Phe binding site [chemical binding]; other site 1034809004682 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1034809004683 active site 1034809004684 dimer interface [polypeptide binding]; other site 1034809004686 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1034809004687 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1034809004688 active site 1034809004690 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1034809004691 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1034809004692 homodimer interface [polypeptide binding]; other site 1034809004693 NAD binding pocket [chemical binding]; other site 1034809004694 ATP binding pocket [chemical binding]; other site 1034809004695 Mg binding site [ion binding]; other site 1034809004696 active-site loop [active] 1034809004698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1034809004699 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1034809004701 NETI protein; Region: NETI; pfam14044 1034809004702 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1034809004703 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1034809004704 tetramer interface [polypeptide binding]; other site 1034809004705 active site 1034809004706 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1034809004710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1034809004712 predicted helix-turn-helix motif with score1037.000,SD 2.72 at aa 57-78 1034809004713 PcrB family; Region: PcrB; pfam01884 1034809004714 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1034809004715 substrate binding site [chemical binding]; other site 1034809004716 putative active site [active] 1034809004717 dimer interface [polypeptide binding]; other site 1034809004720 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1034809004721 Part of AAA domain; Region: AAA_19; pfam13245 1034809004722 Family description; Region: UvrD_C_2; pfam13538 1034809004725 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1034809004726 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1034809004727 nucleotide binding pocket [chemical binding]; other site 1034809004728 K-X-D-G motif; other site 1034809004729 catalytic site [active] 1034809004730 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1034809004731 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1034809004732 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1034809004733 Dimer interface [polypeptide binding]; other site 1034809004740 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1034809004741 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1034809004742 putative dimer interface [polypeptide binding]; other site 1034809004743 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1034809004744 putative dimer interface [polypeptide binding]; other site 1034809004747 predicted helix-turn-helix motif with score998.000,SD 2.59 at aa 146-167 1034809004748 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034809004749 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1034809004750 active site 1034809004751 metal binding site [ion binding]; metal-binding site 1034809004753 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1034809004754 Na binding site [ion binding]; other site 1034809004756 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1034809004758 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1034809004759 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1034809004762 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1034809004763 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1034809004764 GatB domain; Region: GatB_Yqey; pfam02637 1034809004769 putative lipid kinase; Reviewed; Region: PRK13337 1034809004770 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1034809004772 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1034809004773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809004774 S-adenosylmethionine binding site [chemical binding]; other site 1034809004778 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1034809004779 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1034809004781 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1034809004782 active site 1034809004783 DNA polymerase IV; Validated; Region: PRK02406 1034809004784 DNA binding site [nucleotide binding] 1034809004786 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1034809004787 active site 1034809004788 catalytic site [active] 1034809004789 substrate binding site [chemical binding]; other site 1034809004791 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1034809004792 Ferritin-like domain; Region: Ferritin; pfam00210 1034809004793 ferroxidase diiron center [ion binding]; other site 1034809004795 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1034809004796 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034809004797 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1034809004800 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1034809004801 catalytic triad [active] 1034809004803 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1034809004804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809004805 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034809004808 Predicted membrane protein [Function unknown]; Region: COG4129 1034809004809 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1034809004811 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1034809004812 active site 1034809004814 Predicted membrane protein [Function unknown]; Region: COG4758 1034809004815 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1034809004818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1034809004819 Histidine kinase; Region: HisKA_3; pfam07730 1034809004820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809004821 ATP binding site [chemical binding]; other site 1034809004822 Mg2+ binding site [ion binding]; other site 1034809004823 G-X-G motif; other site 1034809004826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034809004827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809004828 active site 1034809004829 phosphorylation site [posttranslational modification] 1034809004830 intermolecular recognition site; other site 1034809004831 dimerization interface [polypeptide binding]; other site 1034809004832 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034809004833 DNA binding residues [nucleotide binding] 1034809004834 dimerization interface [polypeptide binding]; other site 1034809004837 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1034809004839 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1034809004840 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1034809004841 active site 1034809004843 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1034809004845 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1034809004846 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1034809004849 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1034809004851 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1034809004852 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034809004853 FeS/SAM binding site; other site 1034809004854 YfkB-like domain; Region: YfkB; pfam08756 1034809004857 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1034809004858 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1034809004859 proposed catalytic triad [active] 1034809004860 conserved cys residue [active] 1034809004862 glycosyltransferase; Provisional; Region: PRK13481 1034809004863 Transglycosylase; Region: Transgly; pfam00912 1034809004865 recombination regulator RecX; Provisional; Region: recX; PRK14135 1034809004867 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1034809004869 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1034809004870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809004871 Walker A/P-loop; other site 1034809004872 ATP binding site [chemical binding]; other site 1034809004873 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1034809004875 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1034809004877 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1034809004878 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1034809004879 minor groove reading motif; other site 1034809004880 helix-hairpin-helix signature motif; other site 1034809004881 substrate binding pocket [chemical binding]; other site 1034809004882 active site 1034809004883 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1034809004884 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1034809004885 DNA binding and oxoG recognition site [nucleotide binding] 1034809004888 hypothetical protein; Provisional; Region: PRK13662 1034809004890 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034809004891 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1034809004892 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1034809004893 Walker A/P-loop; other site 1034809004894 ATP binding site [chemical binding]; other site 1034809004895 Q-loop/lid; other site 1034809004896 ABC transporter signature motif; other site 1034809004897 Walker B; other site 1034809004898 D-loop; other site 1034809004899 H-loop/switch region; other site 1034809004904 Predicted membrane protein [Function unknown]; Region: COG4129 1034809004905 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1034809004907 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1034809004908 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034809004909 inhibitor-cofactor binding pocket; inhibition site 1034809004910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809004911 catalytic residue [active] 1034809004913 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1034809004914 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1034809004915 catalytic triad [active] 1034809004917 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1034809004918 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1034809004919 putative ligand binding site [chemical binding]; other site 1034809004920 NAD binding site [chemical binding]; other site 1034809004921 catalytic site [active] 1034809004924 ferric uptake regulator; Provisional; Region: fur; PRK09462 1034809004925 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1034809004926 metal binding site 2 [ion binding]; metal-binding site 1034809004927 putative DNA binding helix; other site 1034809004928 metal binding site 1 [ion binding]; metal-binding site 1034809004929 dimer interface [polypeptide binding]; other site 1034809004930 structural Zn2+ binding site [ion binding]; other site 1034809004932 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1034809004933 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1034809004937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1034809004938 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1034809004939 substrate binding pocket [chemical binding]; other site 1034809004940 membrane-bound complex binding site; other site 1034809004941 hinge residues; other site 1034809004942 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1034809004943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809004944 dimer interface [polypeptide binding]; other site 1034809004945 conserved gate region; other site 1034809004946 putative PBP binding loops; other site 1034809004947 ABC-ATPase subunit interface; other site 1034809004951 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1034809004952 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1034809004953 Walker A/P-loop; other site 1034809004954 ATP binding site [chemical binding]; other site 1034809004955 Q-loop/lid; other site 1034809004956 ABC transporter signature motif; other site 1034809004957 Walker B; other site 1034809004958 D-loop; other site 1034809004959 H-loop/switch region; other site 1034809004963 epoxyqueuosine reductase; Region: TIGR00276 1034809004964 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1034809004968 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1034809004970 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1034809004971 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1034809004972 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1034809004973 Class II fumarases; Region: Fumarase_classII; cd01362 1034809004974 active site 1034809004975 tetramer interface [polypeptide binding]; other site 1034809004979 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1034809004980 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1034809004981 active site 1034809004983 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1034809004984 GAF domain; Region: GAF; pfam01590 1034809004985 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1034809004986 Histidine kinase; Region: HisKA_3; pfam07730 1034809004987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809004988 ATP binding site [chemical binding]; other site 1034809004989 Mg2+ binding site [ion binding]; other site 1034809004990 G-X-G motif; other site 1034809004994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034809004995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809004996 active site 1034809004997 phosphorylation site [posttranslational modification] 1034809004998 intermolecular recognition site; other site 1034809004999 dimerization interface [polypeptide binding]; other site 1034809005000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034809005001 DNA binding residues [nucleotide binding] 1034809005002 dimerization interface [polypeptide binding]; other site 1034809005006 predicted helix-turn-helix motif with score1214.000,SD 3.32 at aa 162-183 1034809005007 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034809005008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809005009 non-specific DNA binding site [nucleotide binding]; other site 1034809005010 salt bridge; other site 1034809005011 sequence-specific DNA binding site [nucleotide binding]; other site 1034809005012 predicted helix-turn-helix motif with score983.000,SD 2.53 at aa 23-44 1034809005013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1034809005015 hypothetical protein; Provisional; Region: PRK13676 1034809005017 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1034809005018 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1034809005019 active site 1034809005020 metal binding site [ion binding]; metal-binding site 1034809005021 DNA binding site [nucleotide binding] 1034809005023 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1034809005024 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1034809005025 SdpI/YhfL protein family; Region: SdpI; pfam13630 1034809005027 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1034809005028 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1034809005029 generic binding surface II; other site 1034809005030 generic binding surface I; other site 1034809005031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034809005032 Zn2+ binding site [ion binding]; other site 1034809005033 Mg2+ binding site [ion binding]; other site 1034809005036 Amidohydrolase; Region: Amidohydro_2; pfam04909 1034809005038 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1034809005039 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1034809005042 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1034809005043 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1034809005044 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1034809005045 HIT family signature motif; other site 1034809005046 catalytic residue [active] 1034809005049 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1034809005050 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1034809005051 Walker A/P-loop; other site 1034809005052 ATP binding site [chemical binding]; other site 1034809005053 Q-loop/lid; other site 1034809005054 ABC transporter signature motif; other site 1034809005055 Walker B; other site 1034809005056 D-loop; other site 1034809005057 H-loop/switch region; other site 1034809005061 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1034809005064 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1034809005065 substrate binding site [chemical binding]; other site 1034809005066 active site 1034809005070 ferrochelatase; Provisional; Region: PRK12435 1034809005071 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1034809005072 C-terminal domain interface [polypeptide binding]; other site 1034809005073 active site 1034809005074 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1034809005075 active site 1034809005076 N-terminal domain interface [polypeptide binding]; other site 1034809005079 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1034809005080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1034809005082 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1034809005083 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1034809005085 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1034809005086 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1034809005087 acyl-activating enzyme (AAE) consensus motif; other site 1034809005088 putative AMP binding site [chemical binding]; other site 1034809005089 putative active site [active] 1034809005090 putative CoA binding site [chemical binding]; other site 1034809005092 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1034809005093 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1034809005094 metal binding site [ion binding]; metal-binding site 1034809005095 substrate binding pocket [chemical binding]; other site 1034809005096 hypothetical protein; Validated; Region: PRK00041 1034809005098 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1034809005099 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1034809005100 nudix motif; other site 1034809005103 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1034809005104 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1034809005105 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1034809005106 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1034809005107 active site 1034809005108 substrate-binding site [chemical binding]; other site 1034809005109 metal-binding site [ion binding] 1034809005110 ATP binding site [chemical binding]; other site 1034809005113 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1034809005114 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1034809005115 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1034809005116 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1034809005122 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034809005123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1034809005124 active site 1034809005125 catalytic tetrad [active] 1034809005128 predicted helix-turn-helix motif with score1120.000,SD 3.00 at aa 202-223 1034809005130 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1034809005133 camphor resistance protein CrcB; Provisional; Region: PRK14201 1034809005137 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1034809005138 active site 1034809005139 intersubunit interactions; other site 1034809005140 catalytic residue [active] 1034809005142 RNA polymerase factor sigma-70; Validated; Region: PRK06759 1034809005143 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1034809005144 DNA binding residues [nucleotide binding] 1034809005146 predicted helix-turn-helix motif with score1717.000,SD 5.03 at aa 124-145 1034809005147 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1034809005148 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1034809005150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1034809005151 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1034809005152 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1034809005153 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1034809005154 catalytic motif [active] 1034809005155 Zn binding site [ion binding]; other site 1034809005156 RibD C-terminal domain; Region: RibD_C; cl17279 1034809005160 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1034809005161 Lumazine binding domain; Region: Lum_binding; pfam00677 1034809005162 Lumazine binding domain; Region: Lum_binding; pfam00677 1034809005166 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1034809005167 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1034809005168 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1034809005169 dimerization interface [polypeptide binding]; other site 1034809005170 active site 1034809005173 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1034809005174 homopentamer interface [polypeptide binding]; other site 1034809005175 active site 1034809005177 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1034809005179 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1034809005180 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1034809005182 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1034809005185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809005186 S-adenosylmethionine binding site [chemical binding]; other site 1034809005188 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1034809005190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809005191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809005192 putative substrate translocation pore; other site 1034809005195 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1034809005196 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1034809005197 HIGH motif; other site 1034809005198 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1034809005199 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1034809005200 active site 1034809005201 KMSKS motif; other site 1034809005202 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1034809005203 tRNA binding surface [nucleotide binding]; other site 1034809005208 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1034809005209 active site residue [active] 1034809005211 HI0933-like protein; Region: HI0933_like; pfam03486 1034809005212 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1034809005214 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1034809005215 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1034809005217 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1034809005218 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034809005219 RNA binding surface [nucleotide binding]; other site 1034809005220 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1034809005221 active site 1034809005222 uracil binding [chemical binding]; other site 1034809005226 YtxH-like protein; Region: YtxH; pfam12732 1034809005227 dipeptidase PepV; Reviewed; Region: PRK07318 1034809005228 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1034809005229 active site 1034809005230 metal binding site [ion binding]; metal-binding site 1034809005233 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1034809005234 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1034809005235 homodimer interface [polypeptide binding]; other site 1034809005236 substrate-cofactor binding pocket; other site 1034809005237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809005238 catalytic residue [active] 1034809005241 Phosphotransferase enzyme family; Region: APH; pfam01636 1034809005242 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1034809005243 active site 1034809005244 substrate binding site [chemical binding]; other site 1034809005245 ATP binding site [chemical binding]; other site 1034809005247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809005248 S-adenosylmethionine binding site [chemical binding]; other site 1034809005250 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1034809005251 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1034809005253 Predicted small secreted protein [Function unknown]; Region: COG5584 1034809005254 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1034809005255 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1034809005256 oligomer interface [polypeptide binding]; other site 1034809005257 active site 1034809005258 metal binding site [ion binding]; metal-binding site 1034809005260 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034809005261 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1034809005262 catalytic residues [active] 1034809005264 hypothetical protein; Provisional; Region: PRK13668 1034809005266 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1034809005267 putative tRNA-binding site [nucleotide binding]; other site 1034809005269 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1034809005270 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1034809005271 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1034809005275 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1034809005276 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1034809005277 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034809005278 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034809005283 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1034809005285 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1034809005286 Chorismate mutase type II; Region: CM_2; cl00693 1034809005287 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1034809005290 catabolite control protein A; Region: ccpA; TIGR01481 1034809005291 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034809005292 DNA binding site [nucleotide binding] 1034809005293 domain linker motif; other site 1034809005294 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1034809005295 dimerization interface [polypeptide binding]; other site 1034809005296 effector binding site; other site 1034809005298 predicted helix-turn-helix motif with score1741.000,SD 5.12 at aa 3-24 1034809005302 acetoin reductase; Validated; Region: PRK08643 1034809005303 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1034809005304 NAD binding site [chemical binding]; other site 1034809005305 homotetramer interface [polypeptide binding]; other site 1034809005306 homodimer interface [polypeptide binding]; other site 1034809005307 active site 1034809005308 substrate binding site [chemical binding]; other site 1034809005311 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1034809005312 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1034809005313 active site 1034809005314 Zn binding site [ion binding]; other site 1034809005316 acetyl-CoA synthetase; Provisional; Region: PRK04319 1034809005317 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1034809005318 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1034809005319 active site 1034809005320 acyl-activating enzyme (AAE) consensus motif; other site 1034809005321 putative CoA binding site [chemical binding]; other site 1034809005322 AMP binding site [chemical binding]; other site 1034809005325 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1034809005326 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1034809005327 Potassium binding sites [ion binding]; other site 1034809005328 Cesium cation binding sites [ion binding]; other site 1034809005330 predicted helix-turn-helix motif with score1111.000,SD 2.97 at aa 16-37 1034809005332 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1034809005333 Transglycosylase; Region: Transgly; pfam00912 1034809005336 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1034809005337 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1034809005338 active site 1034809005339 HIGH motif; other site 1034809005340 dimer interface [polypeptide binding]; other site 1034809005341 KMSKS motif; other site 1034809005342 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034809005343 RNA binding surface [nucleotide binding]; other site 1034809005347 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1034809005348 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1034809005349 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1034809005350 protein binding site [polypeptide binding]; other site 1034809005353 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1034809005354 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1034809005355 putative acyl-acceptor binding pocket; other site 1034809005357 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1034809005358 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1034809005359 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034809005360 active site turn [active] 1034809005361 phosphorylation site [posttranslational modification] 1034809005367 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1034809005368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809005369 motif II; other site 1034809005370 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1034809005371 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1034809005372 ligand binding site [chemical binding]; other site 1034809005373 NAD binding site [chemical binding]; other site 1034809005374 dimerization interface [polypeptide binding]; other site 1034809005375 catalytic site [active] 1034809005376 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1034809005377 putative L-serine binding site [chemical binding]; other site 1034809005382 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1034809005383 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034809005384 catalytic residue [active] 1034809005387 OsmC-like protein; Region: OsmC; cl00767 1034809005389 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1034809005390 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1034809005391 active site 1034809005392 catalytic site [active] 1034809005394 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1034809005395 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1034809005396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034809005397 RNA binding surface [nucleotide binding]; other site 1034809005400 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1034809005401 GAF domain; Region: GAF_2; pfam13185 1034809005404 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1034809005406 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1034809005407 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1034809005408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034809005409 catalytic residue [active] 1034809005411 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1034809005412 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1034809005413 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1034809005414 Ligand Binding Site [chemical binding]; other site 1034809005417 hypothetical protein; Provisional; Region: PRK10621 1034809005418 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1034809005422 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1034809005423 dimer interface [polypeptide binding]; other site 1034809005424 catalytic triad [active] 1034809005425 peroxidatic and resolving cysteines [active] 1034809005428 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1034809005429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809005430 S-adenosylmethionine binding site [chemical binding]; other site 1034809005431 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1034809005432 propionate/acetate kinase; Provisional; Region: PRK12379 1034809005436 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1034809005437 Ligand Binding Site [chemical binding]; other site 1034809005439 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1034809005440 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1034809005441 hexamer interface [polypeptide binding]; other site 1034809005442 ligand binding site [chemical binding]; other site 1034809005443 putative active site [active] 1034809005444 NAD(P) binding site [chemical binding]; other site 1034809005448 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1034809005449 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1034809005450 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1034809005451 active site 1034809005453 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1034809005454 metal-dependent hydrolase; Provisional; Region: PRK00685 1034809005456 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1034809005457 Ligand Binding Site [chemical binding]; other site 1034809005459 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1034809005460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1034809005461 DNA-binding site [nucleotide binding]; DNA binding site 1034809005462 DRTGG domain; Region: DRTGG; pfam07085 1034809005463 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1034809005465 predicted helix-turn-helix motif with score1632.000,SD 4.75 at aa 20-41 1034809005469 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1034809005470 DHH family; Region: DHH; pfam01368 1034809005471 DHHA1 domain; Region: DHHA1; pfam02272 1034809005474 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1034809005475 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1034809005476 active site 1034809005477 PHP Thumb interface [polypeptide binding]; other site 1034809005478 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1034809005479 generic binding surface I; other site 1034809005480 generic binding surface II; other site 1034809005484 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1034809005485 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1034809005486 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1034809005487 putative NAD(P) binding site [chemical binding]; other site 1034809005491 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1034809005492 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1034809005494 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1034809005495 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1034809005497 6-phosphofructokinase; Provisional; Region: PRK03202 1034809005498 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1034809005499 active site 1034809005500 ADP/pyrophosphate binding site [chemical binding]; other site 1034809005501 dimerization interface [polypeptide binding]; other site 1034809005502 allosteric effector site; other site 1034809005503 fructose-1,6-bisphosphate binding site; other site 1034809005506 pyruvate kinase; Provisional; Region: PRK06354 1034809005507 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1034809005508 domain interfaces; other site 1034809005509 active site 1034809005510 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1034809005514 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1034809005517 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1034809005518 dimer interface [polypeptide binding]; other site 1034809005519 Citrate synthase; Region: Citrate_synt; pfam00285 1034809005520 active site 1034809005521 citrylCoA binding site [chemical binding]; other site 1034809005522 oxalacetate/citrate binding site [chemical binding]; other site 1034809005523 coenzyme A binding site [chemical binding]; other site 1034809005524 catalytic triad [active] 1034809005527 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1034809005528 isocitrate dehydrogenase; Validated; Region: PRK07362 1034809005531 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809005532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809005533 active site 1034809005534 phosphorylation site [posttranslational modification] 1034809005535 intermolecular recognition site; other site 1034809005536 dimerization interface [polypeptide binding]; other site 1034809005537 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809005538 DNA binding site [nucleotide binding] 1034809005541 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1034809005542 PAS domain; Region: PAS; smart00091 1034809005543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809005544 dimer interface [polypeptide binding]; other site 1034809005545 phosphorylation site [posttranslational modification] 1034809005546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809005547 ATP binding site [chemical binding]; other site 1034809005548 Mg2+ binding site [ion binding]; other site 1034809005549 G-X-G motif; other site 1034809005554 DNA polymerase I; Provisional; Region: PRK05755 1034809005555 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1034809005556 active site 1034809005557 metal binding site 1 [ion binding]; metal-binding site 1034809005558 putative 5' ssDNA interaction site; other site 1034809005559 metal binding site 3; metal-binding site 1034809005560 metal binding site 2 [ion binding]; metal-binding site 1034809005561 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1034809005562 putative DNA binding site [nucleotide binding]; other site 1034809005563 putative metal binding site [ion binding]; other site 1034809005564 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1034809005565 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1034809005566 active site 1034809005567 DNA binding site [nucleotide binding] 1034809005568 catalytic site [active] 1034809005573 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1034809005574 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1034809005575 DNA binding site [nucleotide binding] 1034809005576 catalytic residue [active] 1034809005577 H2TH interface [polypeptide binding]; other site 1034809005578 putative catalytic residues [active] 1034809005579 turnover-facilitating residue; other site 1034809005580 intercalation triad [nucleotide binding]; other site 1034809005581 8OG recognition residue [nucleotide binding]; other site 1034809005582 putative reading head residues; other site 1034809005583 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1034809005584 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1034809005587 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1034809005588 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1034809005589 CoA-binding site [chemical binding]; other site 1034809005590 ATP-binding [chemical binding]; other site 1034809005593 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1034809005594 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1034809005595 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1034809005599 biotin synthase; Validated; Region: PRK06256 1034809005600 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034809005601 FeS/SAM binding site; other site 1034809005602 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1034809005605 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1034809005606 ATP cone domain; Region: ATP-cone; pfam03477 1034809005608 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1034809005609 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1034809005611 primosomal protein DnaI; Reviewed; Region: PRK08939 1034809005612 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1034809005613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809005614 Walker A motif; other site 1034809005615 ATP binding site [chemical binding]; other site 1034809005616 Walker B motif; other site 1034809005619 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1034809005620 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1034809005621 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1034809005622 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1034809005623 active site 1034809005624 dimer interface [polypeptide binding]; other site 1034809005625 motif 1; other site 1034809005626 motif 2; other site 1034809005627 motif 3; other site 1034809005628 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1034809005629 anticodon binding site; other site 1034809005636 lysine transporter; Provisional; Region: PRK10836 1034809005640 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1034809005641 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1034809005642 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1034809005646 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1034809005649 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1034809005650 23S rRNA binding site [nucleotide binding]; other site 1034809005651 L21 binding site [polypeptide binding]; other site 1034809005652 L13 binding site [polypeptide binding]; other site 1034809005655 predicted helix-turn-helix motif with score1000.000,SD 2.59 at aa 63-84 1034809005656 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1034809005658 trigger factor; Provisional; Region: tig; PRK01490 1034809005659 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1034809005660 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1034809005664 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1034809005665 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1034809005666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809005667 Walker A motif; other site 1034809005668 ATP binding site [chemical binding]; other site 1034809005669 Walker B motif; other site 1034809005670 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1034809005675 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1034809005676 G1 box; other site 1034809005677 GTP/Mg2+ binding site [chemical binding]; other site 1034809005678 Switch I region; other site 1034809005679 G2 box; other site 1034809005680 G3 box; other site 1034809005681 Switch II region; other site 1034809005682 G4 box; other site 1034809005683 G5 box; other site 1034809005686 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1034809005687 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1034809005688 tRNA; other site 1034809005689 putative tRNA binding site [nucleotide binding]; other site 1034809005690 putative NADP binding site [chemical binding]; other site 1034809005691 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1034809005696 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1034809005699 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1034809005700 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1034809005701 domain interfaces; other site 1034809005702 active site 1034809005706 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1034809005707 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1034809005708 active site 1034809005710 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1034809005711 dimer interface [polypeptide binding]; other site 1034809005712 active site 1034809005713 Schiff base residues; other site 1034809005716 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1034809005717 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1034809005718 inhibitor-cofactor binding pocket; inhibition site 1034809005719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809005720 catalytic residue [active] 1034809005723 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1034809005724 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1034809005725 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1034809005727 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1034809005729 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1034809005730 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1034809005731 active site 1034809005732 HIGH motif; other site 1034809005733 nucleotide binding site [chemical binding]; other site 1034809005734 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1034809005735 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1034809005736 active site 1034809005737 KMSKS motif; other site 1034809005738 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1034809005739 tRNA binding surface [nucleotide binding]; other site 1034809005740 anticodon binding site; other site 1034809005741 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1034809005746 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1034809005747 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034809005748 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034809005751 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1034809005752 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1034809005755 hypothetical protein; Reviewed; Region: PRK00024 1034809005756 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1034809005757 MPN+ (JAMM) motif; other site 1034809005758 Zinc-binding site [ion binding]; other site 1034809005760 predicted helix-turn-helix motif with score1057.000,SD 2.79 at aa 66-87 1034809005761 rod shape-determining protein MreC; Provisional; Region: PRK13922 1034809005762 rod shape-determining protein MreC; Region: MreC; pfam04085 1034809005764 rod shape-determining protein MreD; Region: MreD; cl01087 1034809005766 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1034809005767 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1034809005769 Protein of unknown function (DUF464); Region: DUF464; cl01080 1034809005771 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1034809005774 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1034809005775 GTP1/OBG; Region: GTP1_OBG; pfam01018 1034809005776 Obg GTPase; Region: Obg; cd01898 1034809005777 G1 box; other site 1034809005778 GTP/Mg2+ binding site [chemical binding]; other site 1034809005779 Switch I region; other site 1034809005780 G2 box; other site 1034809005781 G3 box; other site 1034809005782 Switch II region; other site 1034809005783 G4 box; other site 1034809005784 G5 box; other site 1034809005785 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1034809005791 hypothetical protein; Provisional; Region: PRK04435 1034809005792 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1034809005793 predicted helix-turn-helix motif with score1053.000,SD 2.77 at aa 37-58 1034809005795 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1034809005796 RuvA N terminal domain; Region: RuvA_N; pfam01330 1034809005799 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1034809005800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809005801 Walker A motif; other site 1034809005802 ATP binding site [chemical binding]; other site 1034809005803 Walker B motif; other site 1034809005804 arginine finger; other site 1034809005805 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1034809005810 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1034809005811 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1034809005813 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1034809005814 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1034809005816 Preprotein translocase subunit; Region: YajC; pfam02699 1034809005818 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1034809005819 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1034809005820 Protein export membrane protein; Region: SecD_SecF; cl14618 1034809005821 Protein export membrane protein; Region: SecD_SecF; pfam02355 1034809005825 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1034809005826 DHH family; Region: DHH; pfam01368 1034809005827 DHHA1 domain; Region: DHHA1; pfam02272 1034809005828 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1034809005832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809005833 active site 1034809005835 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1034809005836 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034809005837 Zn2+ binding site [ion binding]; other site 1034809005838 Mg2+ binding site [ion binding]; other site 1034809005839 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1034809005840 synthetase active site [active] 1034809005841 NTP binding site [chemical binding]; other site 1034809005842 metal binding site [ion binding]; metal-binding site 1034809005843 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1034809005844 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1034809005848 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1034809005849 putative active site [active] 1034809005850 dimerization interface [polypeptide binding]; other site 1034809005851 putative tRNAtyr binding site [nucleotide binding]; other site 1034809005853 Bacterial SH3 domain; Region: SH3_3; pfam08239 1034809005854 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1034809005855 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1034809005856 active site 1034809005857 metal binding site [ion binding]; metal-binding site 1034809005860 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1034809005861 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1034809005862 dimer interface [polypeptide binding]; other site 1034809005863 motif 1; other site 1034809005864 active site 1034809005865 motif 2; other site 1034809005866 motif 3; other site 1034809005867 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1034809005868 anticodon binding site; other site 1034809005872 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1034809005873 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1034809005874 dimer interface [polypeptide binding]; other site 1034809005875 anticodon binding site; other site 1034809005876 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1034809005877 homodimer interface [polypeptide binding]; other site 1034809005878 motif 1; other site 1034809005879 active site 1034809005880 motif 2; other site 1034809005881 GAD domain; Region: GAD; pfam02938 1034809005882 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1034809005883 motif 3; other site 1034809005889 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1034809005890 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1034809005891 putative ATP binding site [chemical binding]; other site 1034809005892 putative substrate interface [chemical binding]; other site 1034809005894 recombination factor protein RarA; Reviewed; Region: PRK13342 1034809005895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809005896 Walker A motif; other site 1034809005897 ATP binding site [chemical binding]; other site 1034809005898 Walker B motif; other site 1034809005899 arginine finger; other site 1034809005900 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1034809005903 Predicted transcriptional regulator [Transcription]; Region: COG1959 1034809005904 Transcriptional regulator; Region: Rrf2; pfam02082 1034809005907 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1034809005908 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1034809005910 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1034809005911 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1034809005912 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034809005913 catalytic residue [active] 1034809005916 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1034809005917 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1034809005920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034809005921 TPR motif; other site 1034809005922 binding surface 1034809005923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034809005924 binding surface 1034809005925 TPR motif; other site 1034809005926 TPR repeat; Region: TPR_11; pfam13414 1034809005932 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1034809005933 AAA domain; Region: AAA_30; pfam13604 1034809005934 Family description; Region: UvrD_C_2; pfam13538 1034809005936 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1034809005937 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1034809005938 motif 1; other site 1034809005939 active site 1034809005940 motif 2; other site 1034809005941 motif 3; other site 1034809005942 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1034809005943 DHHA1 domain; Region: DHHA1; pfam02272 1034809005948 hypothetical protein; Provisional; Region: PRK05473 1034809005950 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1034809005952 hypothetical protein; Provisional; Region: PRK13678 1034809005954 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1034809005955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809005956 S-adenosylmethionine binding site [chemical binding]; other site 1034809005958 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1034809005959 Peptidase family U32; Region: Peptidase_U32; pfam01136 1034809005962 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1034809005963 Peptidase family U32; Region: Peptidase_U32; pfam01136 1034809005966 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1034809005967 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1034809005968 Sugar specificity; other site 1034809005969 Pyrimidine base specificity; other site 1034809005970 ATP-binding site [chemical binding]; other site 1034809005973 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1034809005974 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1034809005975 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1034809005979 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1034809005980 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1034809005982 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1034809005984 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 1034809005985 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1034809005986 carboxyltransferase (CT) interaction site; other site 1034809005987 biotinylation site [posttranslational modification]; other site 1034809005989 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034809005990 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1034809005991 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1034809005992 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1034809005998 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1034809005999 putative active site [active] 1034809006001 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1034809006003 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1034809006004 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1034809006006 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1034809006007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809006008 active site 1034809006009 motif I; other site 1034809006010 motif II; other site 1034809006012 GTPase YqeH; Provisional; Region: PRK13796 1034809006013 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1034809006014 GTP/Mg2+ binding site [chemical binding]; other site 1034809006015 G4 box; other site 1034809006016 G5 box; other site 1034809006017 G1 box; other site 1034809006018 Switch I region; other site 1034809006019 G2 box; other site 1034809006020 G3 box; other site 1034809006021 Switch II region; other site 1034809006024 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1034809006025 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1034809006026 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1034809006027 shikimate binding site; other site 1034809006028 NAD(P) binding site [chemical binding]; other site 1034809006031 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1034809006033 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1034809006034 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1034809006035 active site 1034809006036 (T/H)XGH motif; other site 1034809006038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034809006039 Zn2+ binding site [ion binding]; other site 1034809006040 Mg2+ binding site [ion binding]; other site 1034809006042 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1034809006044 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1034809006045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809006046 S-adenosylmethionine binding site [chemical binding]; other site 1034809006048 SLBB domain; Region: SLBB; pfam10531 1034809006049 comEA protein; Region: comE; TIGR01259 1034809006050 Helix-hairpin-helix motif; Region: HHH; pfam00633 1034809006051 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1034809006055 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1034809006056 catalytic motif [active] 1034809006057 Zn binding site [ion binding]; other site 1034809006060 Competence protein; Region: Competence; pfam03772 1034809006061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1034809006063 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1034809006064 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1034809006066 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1034809006068 GTP-binding protein LepA; Provisional; Region: PRK05433 1034809006069 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1034809006070 G1 box; other site 1034809006071 putative GEF interaction site [polypeptide binding]; other site 1034809006072 GTP/Mg2+ binding site [chemical binding]; other site 1034809006073 Switch I region; other site 1034809006074 G2 box; other site 1034809006075 G3 box; other site 1034809006076 Switch II region; other site 1034809006077 G4 box; other site 1034809006078 G5 box; other site 1034809006079 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1034809006080 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1034809006081 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1034809006088 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1034809006089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034809006090 FeS/SAM binding site; other site 1034809006091 HemN C-terminal domain; Region: HemN_C; pfam06969 1034809006094 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1034809006096 heat shock protein GrpE; Provisional; Region: PRK14140 1034809006097 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1034809006098 dimer interface [polypeptide binding]; other site 1034809006099 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1034809006102 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1034809006103 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1034809006104 nucleotide binding site [chemical binding]; other site 1034809006105 NEF interaction site [polypeptide binding]; other site 1034809006106 SBD interface [polypeptide binding]; other site 1034809006112 chaperone protein DnaJ; Provisional; Region: PRK14280 1034809006113 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1034809006114 HSP70 interaction site [polypeptide binding]; other site 1034809006115 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1034809006116 substrate binding site [polypeptide binding]; other site 1034809006117 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1034809006118 Zn binding sites [ion binding]; other site 1034809006119 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1034809006120 dimer interface [polypeptide binding]; other site 1034809006126 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1034809006127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809006128 S-adenosylmethionine binding site [chemical binding]; other site 1034809006131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1034809006133 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1034809006134 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1034809006135 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034809006136 FeS/SAM binding site; other site 1034809006140 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1034809006143 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1034809006145 hypothetical protein; Provisional; Region: PRK13665 1034809006146 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1034809006147 PhoH-like protein; Region: PhoH; pfam02562 1034809006150 metal-binding heat shock protein; Provisional; Region: PRK00016 1034809006153 CDS lacks an appropriate translational start site 1034809006155 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1034809006156 active site 1034809006157 catalytic motif [active] 1034809006158 Zn binding site [ion binding]; other site 1034809006160 GTPase Era; Reviewed; Region: era; PRK00089 1034809006161 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1034809006162 G1 box; other site 1034809006163 GTP/Mg2+ binding site [chemical binding]; other site 1034809006164 Switch I region; other site 1034809006165 G2 box; other site 1034809006166 Switch II region; other site 1034809006167 G3 box; other site 1034809006168 G4 box; other site 1034809006169 G5 box; other site 1034809006170 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1034809006174 DNA repair protein RecO; Region: reco; TIGR00613 1034809006175 Recombination protein O N terminal; Region: RecO_N; pfam11967 1034809006176 Recombination protein O C terminal; Region: RecO_C; pfam02565 1034809006178 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1034809006179 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1034809006180 motif 1; other site 1034809006181 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1034809006182 active site 1034809006183 motif 2; other site 1034809006184 motif 3; other site 1034809006185 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1034809006186 anticodon binding site; other site 1034809006191 HTH domain; Region: HTH_11; pfam08279 1034809006192 FOG: CBS domain [General function prediction only]; Region: COG0517 1034809006193 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1034809006196 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1034809006198 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1034809006199 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1034809006200 active site 1034809006201 metal binding site [ion binding]; metal-binding site 1034809006202 interdomain interaction site; other site 1034809006205 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1034809006206 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1034809006207 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1034809006208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034809006209 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1034809006210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1034809006211 DNA binding residues [nucleotide binding] 1034809006218 predicted helix-turn-helix motif with score1909.000,SD 5.69 at aa 292-313 1034809006220 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1034809006221 Family of unknown function (DUF633); Region: DUF633; pfam04816 1034809006223 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1034809006224 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1034809006225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1034809006226 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1034809006227 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1034809006229 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1034809006230 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1034809006231 ATP binding site [chemical binding]; other site 1034809006232 Mg++ binding site [ion binding]; other site 1034809006233 motif III; other site 1034809006234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034809006235 nucleotide binding region [chemical binding]; other site 1034809006236 ATP-binding site [chemical binding]; other site 1034809006239 endonuclease IV; Provisional; Region: PRK01060 1034809006240 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1034809006241 AP (apurinic/apyrimidinic) site pocket; other site 1034809006242 DNA interaction; other site 1034809006243 Metal-binding active site; metal-binding site 1034809006247 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1034809006248 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1034809006252 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1034809006253 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809006254 ABC-ATPase subunit interface; other site 1034809006255 dimer interface [polypeptide binding]; other site 1034809006256 putative PBP binding regions; other site 1034809006258 ferric uptake regulator; Provisional; Region: fur; PRK09462 1034809006259 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1034809006260 metal binding site 2 [ion binding]; metal-binding site 1034809006261 putative DNA binding helix; other site 1034809006262 metal binding site 1 [ion binding]; metal-binding site 1034809006263 dimer interface [polypeptide binding]; other site 1034809006264 structural Zn2+ binding site [ion binding]; other site 1034809006266 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1034809006267 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1034809006268 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1034809006272 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1034809006273 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034809006274 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034809006275 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1034809006279 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1034809006282 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1034809006283 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1034809006285 Rhomboid family; Region: Rhomboid; pfam01694 1034809006286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1034809006287 binding surface 1034809006288 TPR motif; other site 1034809006289 TPR repeat; Region: TPR_11; pfam13414 1034809006292 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1034809006294 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1034809006295 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1034809006296 nucleotide binding site [chemical binding]; other site 1034809006300 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1034809006302 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1034809006304 Type II/IV secretion system protein; Region: T2SE; pfam00437 1034809006305 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1034809006306 Walker A motif; other site 1034809006307 ATP binding site [chemical binding]; other site 1034809006308 Walker B motif; other site 1034809006312 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1034809006313 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1034809006314 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1034809006318 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1034809006320 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1034809006321 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1034809006322 ADP binding site [chemical binding]; other site 1034809006323 magnesium binding site [ion binding]; other site 1034809006324 putative shikimate binding site; other site 1034809006328 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1034809006329 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1034809006332 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1034809006333 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1034809006334 tetramer interface [polypeptide binding]; other site 1034809006335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809006336 catalytic residue [active] 1034809006338 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1034809006339 tetramer interface [polypeptide binding]; other site 1034809006340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809006341 catalytic residue [active] 1034809006342 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1034809006343 active site residue [active] 1034809006345 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1034809006347 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1034809006349 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1034809006350 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1034809006351 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1034809006352 active site 1034809006356 elongation factor P; Validated; Region: PRK00529 1034809006357 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1034809006358 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1034809006359 RNA binding site [nucleotide binding]; other site 1034809006360 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1034809006361 RNA binding site [nucleotide binding]; other site 1034809006366 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1034809006367 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1034809006368 carboxyltransferase (CT) interaction site; other site 1034809006369 biotinylation site [posttranslational modification]; other site 1034809006371 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1034809006372 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034809006373 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1034809006374 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1034809006381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1034809006383 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1034809006384 putative RNA binding site [nucleotide binding]; other site 1034809006386 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1034809006387 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1034809006388 generic binding surface II; other site 1034809006389 generic binding surface I; other site 1034809006392 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1034809006394 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1034809006395 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1034809006396 substrate binding pocket [chemical binding]; other site 1034809006397 chain length determination region; other site 1034809006398 substrate-Mg2+ binding site; other site 1034809006399 catalytic residues [active] 1034809006400 aspartate-rich region 1; other site 1034809006401 active site lid residues [active] 1034809006402 aspartate-rich region 2; other site 1034809006406 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1034809006407 arginine repressor; Provisional; Region: PRK04280 1034809006408 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1034809006411 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1034809006412 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1034809006413 Walker A/P-loop; other site 1034809006414 ATP binding site [chemical binding]; other site 1034809006415 Q-loop/lid; other site 1034809006416 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1034809006417 ABC transporter signature motif; other site 1034809006418 Walker B; other site 1034809006419 D-loop; other site 1034809006420 H-loop/switch region; other site 1034809006423 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1034809006425 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1034809006426 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1034809006427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809006428 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034809006433 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1034809006434 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1034809006435 tetramer interface [polypeptide binding]; other site 1034809006436 TPP-binding site [chemical binding]; other site 1034809006437 heterodimer interface [polypeptide binding]; other site 1034809006438 phosphorylation loop region [posttranslational modification] 1034809006440 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1034809006441 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1034809006442 alpha subunit interface [polypeptide binding]; other site 1034809006443 TPP binding site [chemical binding]; other site 1034809006444 heterodimer interface [polypeptide binding]; other site 1034809006445 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1034809006448 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1034809006449 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1034809006450 E3 interaction surface; other site 1034809006451 lipoyl attachment site [posttranslational modification]; other site 1034809006452 e3 binding domain; Region: E3_binding; pfam02817 1034809006453 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1034809006458 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1034809006461 Predicted membrane protein [Function unknown]; Region: COG4129 1034809006462 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1034809006463 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1034809006466 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1034809006467 peptidase T-like protein; Region: PepT-like; TIGR01883 1034809006468 metal binding site [ion binding]; metal-binding site 1034809006473 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1034809006474 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1034809006475 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1034809006478 predicted helix-turn-helix motif with score1117.000,SD 2.99 at aa 198-219 1034809006480 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034809006481 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034809006482 DNA binding site [nucleotide binding] 1034809006483 domain linker motif; other site 1034809006484 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1034809006487 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1034809006488 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1034809006489 Ca binding site [ion binding]; other site 1034809006490 active site 1034809006491 catalytic site [active] 1034809006493 Helix-turn-helix domain; Region: HTH_18; pfam12833 1034809006494 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1034809006499 predicted helix-turn-helix motif with score1352.000,SD 3.79 at aa 22-43 1034809006500 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1034809006501 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1034809006502 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1034809006505 ribonuclease Z; Region: RNase_Z; TIGR02651 1034809006507 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1034809006508 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1034809006510 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1034809006511 classical (c) SDRs; Region: SDR_c; cd05233 1034809006512 NAD(P) binding site [chemical binding]; other site 1034809006513 active site 1034809006515 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034809006516 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1034809006517 active site 1034809006518 catalytic tetrad [active] 1034809006520 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1034809006521 dimer interface [polypeptide binding]; other site 1034809006522 ADP-ribose binding site [chemical binding]; other site 1034809006523 active site 1034809006524 nudix motif; other site 1034809006525 metal binding site [ion binding]; metal-binding site 1034809006528 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1034809006529 metal binding site 2 [ion binding]; metal-binding site 1034809006530 putative DNA binding helix; other site 1034809006531 metal binding site 1 [ion binding]; metal-binding site 1034809006532 dimer interface [polypeptide binding]; other site 1034809006533 structural Zn2+ binding site [ion binding]; other site 1034809006535 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1034809006536 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1034809006537 active site 1034809006538 Int/Topo IB signature motif; other site 1034809006541 Domain of unknown function (DUF309); Region: DUF309; cl00667 1034809006543 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1034809006545 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1034809006547 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1034809006548 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034809006549 RNA binding surface [nucleotide binding]; other site 1034809006550 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1034809006551 active site 1034809006555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809006556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809006557 active site 1034809006558 phosphorylation site [posttranslational modification] 1034809006559 intermolecular recognition site; other site 1034809006560 dimerization interface [polypeptide binding]; other site 1034809006561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809006562 DNA binding site [nucleotide binding] 1034809006565 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1034809006566 dimerization interface [polypeptide binding]; other site 1034809006567 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1034809006568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809006569 dimer interface [polypeptide binding]; other site 1034809006570 phosphorylation site [posttranslational modification] 1034809006571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809006572 ATP binding site [chemical binding]; other site 1034809006573 Mg2+ binding site [ion binding]; other site 1034809006574 G-X-G motif; other site 1034809006578 Predicted membrane protein [Function unknown]; Region: COG3601 1034809006579 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1034809006580 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1034809006581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1034809006583 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1034809006584 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034809006585 ATP binding site [chemical binding]; other site 1034809006586 putative Mg++ binding site [ion binding]; other site 1034809006587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034809006588 nucleotide binding region [chemical binding]; other site 1034809006589 ATP-binding site [chemical binding]; other site 1034809006593 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034809006595 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1034809006596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1034809006597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809006600 Amidohydrolase; Region: Amidohydro_2; pfam04909 1034809006602 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1034809006603 active site 1034809006604 homotetramer interface [polypeptide binding]; other site 1034809006605 homodimer interface [polypeptide binding]; other site 1034809006609 cytidylate kinase; Provisional; Region: cmk; PRK00023 1034809006610 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1034809006611 CMP-binding site; other site 1034809006612 The sites determining sugar specificity; other site 1034809006615 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1034809006616 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1034809006617 RNA binding site [nucleotide binding]; other site 1034809006618 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1034809006619 RNA binding site [nucleotide binding]; other site 1034809006620 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1034809006621 RNA binding site [nucleotide binding]; other site 1034809006622 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1034809006623 RNA binding site [nucleotide binding]; other site 1034809006628 GTP-binding protein Der; Reviewed; Region: PRK00093 1034809006629 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1034809006630 G1 box; other site 1034809006631 GTP/Mg2+ binding site [chemical binding]; other site 1034809006632 Switch I region; other site 1034809006633 G2 box; other site 1034809006634 Switch II region; other site 1034809006635 G3 box; other site 1034809006636 G4 box; other site 1034809006637 G5 box; other site 1034809006638 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1034809006639 G1 box; other site 1034809006640 GTP/Mg2+ binding site [chemical binding]; other site 1034809006641 Switch I region; other site 1034809006642 G2 box; other site 1034809006643 G3 box; other site 1034809006644 Switch II region; other site 1034809006645 G4 box; other site 1034809006646 G5 box; other site 1034809006651 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1034809006652 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1034809006653 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1034809006656 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1034809006657 IHF dimer interface [polypeptide binding]; other site 1034809006658 IHF - DNA interface [nucleotide binding]; other site 1034809006661 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1034809006662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809006663 S-adenosylmethionine binding site [chemical binding]; other site 1034809006666 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1034809006667 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1034809006668 substrate binding pocket [chemical binding]; other site 1034809006669 chain length determination region; other site 1034809006670 substrate-Mg2+ binding site; other site 1034809006671 catalytic residues [active] 1034809006672 aspartate-rich region 1; other site 1034809006673 active site lid residues [active] 1034809006674 aspartate-rich region 2; other site 1034809006678 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1034809006679 active site 1034809006680 multimer interface [polypeptide binding]; other site 1034809006683 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1034809006684 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1034809006685 Tetramer interface [polypeptide binding]; other site 1034809006686 active site 1034809006687 FMN-binding site [chemical binding]; other site 1034809006692 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1034809006693 active site 1034809006694 dimer interface [polypeptide binding]; other site 1034809006695 metal binding site [ion binding]; metal-binding site 1034809006697 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1034809006698 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1034809006699 hinge; other site 1034809006700 active site 1034809006704 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 1034809006705 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1034809006706 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1034809006707 UPF0302 domain; Region: UPF0302; pfam08864 1034809006708 IDEAL domain; Region: IDEAL; cl07452 1034809006710 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 1034809006712 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1034809006716 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1034809006717 homodimer interface [polypeptide binding]; other site 1034809006718 metal binding site [ion binding]; metal-binding site 1034809006720 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1034809006721 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1034809006723 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1034809006724 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1034809006725 active site 1034809006726 NTP binding site [chemical binding]; other site 1034809006727 metal binding triad [ion binding]; metal-binding site 1034809006728 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1034809006729 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1034809006731 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1034809006732 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1034809006733 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1034809006734 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1034809006736 predicted helix-turn-helix motif with score1405.000,SD 3.97 at aa 20-41 1034809006739 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1034809006740 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1034809006741 active site 1034809006742 catalytic site [active] 1034809006743 substrate binding site [chemical binding]; other site 1034809006744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1034809006745 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1034809006748 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1034809006749 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1034809006750 putative dimer interface [polypeptide binding]; other site 1034809006751 putative anticodon binding site; other site 1034809006752 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1034809006753 homodimer interface [polypeptide binding]; other site 1034809006754 motif 1; other site 1034809006755 motif 2; other site 1034809006756 active site 1034809006757 motif 3; other site 1034809006761 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1034809006762 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1034809006764 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1034809006765 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1034809006766 minor groove reading motif; other site 1034809006767 helix-hairpin-helix signature motif; other site 1034809006768 substrate binding pocket [chemical binding]; other site 1034809006769 active site 1034809006770 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1034809006774 Transglycosylase; Region: Transgly; pfam00912 1034809006775 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1034809006776 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1034809006779 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1034809006781 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1034809006783 hypothetical protein; Provisional; Region: PRK13660 1034809006785 cell division protein GpsB; Provisional; Region: PRK14127 1034809006786 DivIVA domain; Region: DivI1A_domain; TIGR03544 1034809006788 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1034809006789 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1034809006790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1034809006795 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1034809006796 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1034809006797 putative NAD(P) binding site [chemical binding]; other site 1034809006798 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1034809006799 Dynamin family; Region: Dynamin_N; pfam00350 1034809006800 G1 box; other site 1034809006801 GTP/Mg2+ binding site [chemical binding]; other site 1034809006802 G2 box; other site 1034809006803 Switch I region; other site 1034809006804 G3 box; other site 1034809006805 Switch II region; other site 1034809006806 G4 box; other site 1034809006807 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1034809006808 Dynamin family; Region: Dynamin_N; pfam00350 1034809006809 G1 box; other site 1034809006810 GTP/Mg2+ binding site [chemical binding]; other site 1034809006811 G2 box; other site 1034809006812 Switch I region; other site 1034809006813 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1034809006814 G3 box; other site 1034809006815 Switch II region; other site 1034809006816 GTP/Mg2+ binding site [chemical binding]; other site 1034809006817 G4 box; other site 1034809006818 G5 box; other site 1034809006823 5'-3' exonuclease; Region: 53EXOc; smart00475 1034809006824 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1034809006825 active site 1034809006826 metal binding site 1 [ion binding]; metal-binding site 1034809006827 putative 5' ssDNA interaction site; other site 1034809006828 metal binding site 3; metal-binding site 1034809006829 metal binding site 2 [ion binding]; metal-binding site 1034809006830 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1034809006831 putative DNA binding site [nucleotide binding]; other site 1034809006832 putative metal binding site [ion binding]; other site 1034809006835 anthranilate synthase component I; Provisional; Region: PRK13567 1034809006836 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1034809006837 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1034809006841 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1034809006842 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1034809006843 glutamine binding [chemical binding]; other site 1034809006844 catalytic triad [active] 1034809006847 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1034809006848 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1034809006850 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1034809006851 active site 1034809006852 ribulose/triose binding site [chemical binding]; other site 1034809006853 phosphate binding site [ion binding]; other site 1034809006854 substrate (anthranilate) binding pocket [chemical binding]; other site 1034809006855 product (indole) binding pocket [chemical binding]; other site 1034809006857 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1034809006858 active site 1034809006860 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1034809006861 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1034809006862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809006863 catalytic residue [active] 1034809006866 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1034809006867 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1034809006868 substrate binding site [chemical binding]; other site 1034809006869 active site 1034809006870 catalytic residues [active] 1034809006871 heterodimer interface [polypeptide binding]; other site 1034809006874 FemAB family; Region: FemAB; pfam02388 1034809006876 FemAB family; Region: FemAB; pfam02388 1034809006878 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1034809006879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809006880 active site 1034809006881 motif I; other site 1034809006882 motif II; other site 1034809006884 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1034809006885 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1034809006886 intersubunit interface [polypeptide binding]; other site 1034809006890 oligoendopeptidase F; Region: pepF; TIGR00181 1034809006891 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1034809006892 active site 1034809006893 Zn binding site [ion binding]; other site 1034809006897 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1034809006898 PhoU domain; Region: PhoU; pfam01895 1034809006899 PhoU domain; Region: PhoU; pfam01895 1034809006902 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1034809006903 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1034809006904 Walker A/P-loop; other site 1034809006905 ATP binding site [chemical binding]; other site 1034809006906 Q-loop/lid; other site 1034809006907 ABC transporter signature motif; other site 1034809006908 Walker B; other site 1034809006909 D-loop; other site 1034809006910 H-loop/switch region; other site 1034809006914 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1034809006915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809006916 dimer interface [polypeptide binding]; other site 1034809006917 conserved gate region; other site 1034809006918 ABC-ATPase subunit interface; other site 1034809006921 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1034809006922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809006923 dimer interface [polypeptide binding]; other site 1034809006924 conserved gate region; other site 1034809006925 putative PBP binding loops; other site 1034809006926 ABC-ATPase subunit interface; other site 1034809006929 PBP superfamily domain; Region: PBP_like_2; cl17296 1034809006931 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1034809006932 S1 domain; Region: S1_2; pfam13509 1034809006933 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1034809006934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809006935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809006936 ABC transporter; Region: ABC_tran_2; pfam12848 1034809006937 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809006940 aspartate kinase; Reviewed; Region: PRK06635 1034809006941 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1034809006942 putative nucleotide binding site [chemical binding]; other site 1034809006943 putative catalytic residues [active] 1034809006944 putative Mg ion binding site [ion binding]; other site 1034809006945 putative aspartate binding site [chemical binding]; other site 1034809006946 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1034809006947 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1034809006950 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1034809006951 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1034809006952 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1034809006955 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1034809006956 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1034809006957 dimer interface [polypeptide binding]; other site 1034809006958 active site 1034809006959 catalytic residue [active] 1034809006962 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1034809006963 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1034809006964 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1034809006967 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1034809006968 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1034809006969 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1034809006970 active site 1034809006971 trimer interface [polypeptide binding]; other site 1034809006972 substrate binding site [chemical binding]; other site 1034809006973 CoA binding site [chemical binding]; other site 1034809006981 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1034809006982 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1034809006983 metal binding site [ion binding]; metal-binding site 1034809006984 dimer interface [polypeptide binding]; other site 1034809006986 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1034809006987 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1034809006988 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1034809006989 catalytic residue [active] 1034809006992 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1034809006993 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1034809006994 active site 1034809006995 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1034809006996 substrate binding site [chemical binding]; other site 1034809006997 catalytic residues [active] 1034809006998 dimer interface [polypeptide binding]; other site 1034809007003 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1034809007004 DNA-binding site [nucleotide binding]; DNA binding site 1034809007005 RNA-binding motif; other site 1034809007008 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1034809007010 acylphosphatase; Provisional; Region: PRK14431 1034809007013 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1034809007017 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1034809007019 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1034809007023 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1034809007024 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1034809007025 metal ion-dependent adhesion site (MIDAS); other site 1034809007026 MoxR-like ATPases [General function prediction only]; Region: COG0714 1034809007027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809007028 Walker A motif; other site 1034809007029 ATP binding site [chemical binding]; other site 1034809007030 Walker B motif; other site 1034809007031 arginine finger; other site 1034809007032 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1034809007035 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1034809007036 active site 1034809007037 metal binding site [ion binding]; metal-binding site 1034809007038 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1034809007039 active site 1034809007040 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1034809007041 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1034809007042 E3 interaction surface; other site 1034809007043 lipoyl attachment site [posttranslational modification]; other site 1034809007044 e3 binding domain; Region: E3_binding; pfam02817 1034809007045 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1034809007051 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1034809007052 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1034809007053 TPP-binding site [chemical binding]; other site 1034809007054 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1034809007058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034809007059 HAMP domain; Region: HAMP; pfam00672 1034809007060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809007061 dimer interface [polypeptide binding]; other site 1034809007062 phosphorylation site [posttranslational modification] 1034809007063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809007064 ATP binding site [chemical binding]; other site 1034809007065 Mg2+ binding site [ion binding]; other site 1034809007066 G-X-G motif; other site 1034809007070 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809007071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809007072 active site 1034809007073 phosphorylation site [posttranslational modification] 1034809007074 intermolecular recognition site; other site 1034809007075 dimerization interface [polypeptide binding]; other site 1034809007076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809007077 DNA binding site [nucleotide binding] 1034809007081 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1034809007082 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1034809007083 active site 1034809007085 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1034809007086 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1034809007087 active site 1034809007088 homodimer interface [polypeptide binding]; other site 1034809007091 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1034809007092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809007093 Coenzyme A binding pocket [chemical binding]; other site 1034809007095 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1034809007096 C-terminal peptidase (prc); Region: prc; TIGR00225 1034809007097 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1034809007098 protein binding site [polypeptide binding]; other site 1034809007099 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1034809007100 Catalytic dyad [active] 1034809007101 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1034809007105 hypothetical protein; Provisional; Region: PRK13672 1034809007107 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1034809007108 HPr interaction site; other site 1034809007109 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1034809007110 active site 1034809007111 phosphorylation site [posttranslational modification] 1034809007114 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1034809007115 SelR domain; Region: SelR; pfam01641 1034809007117 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1034809007119 EDD domain protein, DegV family; Region: DegV; TIGR00762 1034809007120 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1034809007122 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1034809007123 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1034809007124 folate binding site [chemical binding]; other site 1034809007125 NADP+ binding site [chemical binding]; other site 1034809007128 thymidylate synthase; Region: thym_sym; TIGR03284 1034809007129 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1034809007130 dimerization interface [polypeptide binding]; other site 1034809007131 active site 1034809007134 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 1034809007137 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1034809007139 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1034809007141 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1034809007143 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1034809007144 RNA/DNA hybrid binding site [nucleotide binding]; other site 1034809007145 active site 1034809007146 predicted helix-turn-helix motif with score1065.000,SD 2.81 at aa 19-40 1034809007147 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1034809007149 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1034809007151 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1034809007152 active site 1034809007153 P-loop; other site 1034809007154 phosphorylation site [posttranslational modification] 1034809007156 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034809007157 active site 1034809007158 phosphorylation site [posttranslational modification] 1034809007160 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1034809007161 active site 1034809007162 dimer interface [polypeptide binding]; other site 1034809007163 magnesium binding site [ion binding]; other site 1034809007165 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1034809007166 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1034809007167 AP (apurinic/apyrimidinic) site pocket; other site 1034809007168 DNA interaction; other site 1034809007169 Metal-binding active site; metal-binding site 1034809007171 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1034809007172 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1034809007173 intersubunit interface [polypeptide binding]; other site 1034809007174 active site 1034809007175 Zn2+ binding site [ion binding]; other site 1034809007177 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1034809007178 PRD domain; Region: PRD; pfam00874 1034809007179 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1034809007180 active site 1034809007181 P-loop; other site 1034809007182 phosphorylation site [posttranslational modification] 1034809007183 predicted helix-turn-helix motif with score1619.000,SD 4.70 at aa 23-44 1034809007185 predicted helix-turn-helix motif with score1216.000,SD 3.33 at aa 109-130 1034809007188 CDS contains a nonsense mutation after residue 41 1034809007189 prephenate dehydrogenase; Validated; Region: PRK06545 1034809007190 prephenate dehydrogenase; Validated; Region: PRK08507 1034809007191 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1034809007194 DNA polymerase IV; Reviewed; Region: PRK03103 1034809007195 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1034809007196 active site 1034809007197 DNA binding site [nucleotide binding] 1034809007198 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1034809007200 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1034809007201 active site 1 [active] 1034809007202 dimer interface [polypeptide binding]; other site 1034809007203 hexamer interface [polypeptide binding]; other site 1034809007204 active site 2 [active] 1034809007206 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1034809007208 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1034809007213 Predicted integral membrane protein [Function unknown]; Region: COG0392 1034809007214 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1034809007215 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1034809007219 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1034809007220 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1034809007222 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1034809007223 amino acid carrier protein; Region: agcS; TIGR00835 1034809007226 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1034809007227 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1034809007228 CAP-like domain; other site 1034809007229 active site 1034809007230 primary dimer interface [polypeptide binding]; other site 1034809007231 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1034809007238 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1034809007239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809007240 ATP binding site [chemical binding]; other site 1034809007241 Mg2+ binding site [ion binding]; other site 1034809007242 G-X-G motif; other site 1034809007243 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1034809007244 anchoring element; other site 1034809007245 dimer interface [polypeptide binding]; other site 1034809007246 ATP binding site [chemical binding]; other site 1034809007247 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1034809007248 active site 1034809007249 putative metal-binding site [ion binding]; other site 1034809007250 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1034809007257 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1034809007260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1034809007262 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1034809007263 active site 1034809007265 aconitate hydratase; Validated; Region: PRK09277 1034809007266 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1034809007267 substrate binding site [chemical binding]; other site 1034809007268 ligand binding site [chemical binding]; other site 1034809007269 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1034809007270 substrate binding site [chemical binding]; other site 1034809007275 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1034809007278 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1034809007279 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1034809007282 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1034809007283 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1034809007284 Walker A/P-loop; other site 1034809007285 ATP binding site [chemical binding]; other site 1034809007286 Q-loop/lid; other site 1034809007287 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1034809007288 ABC transporter signature motif; other site 1034809007289 Walker B; other site 1034809007290 D-loop; other site 1034809007291 H-loop/switch region; other site 1034809007293 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1034809007294 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1034809007295 active site 1034809007296 metal binding site [ion binding]; metal-binding site 1034809007297 DNA binding site [nucleotide binding] 1034809007298 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1034809007301 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1034809007303 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 1034809007305 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1034809007306 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1034809007307 TPP-binding site [chemical binding]; other site 1034809007308 dimer interface [polypeptide binding]; other site 1034809007309 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1034809007310 PYR/PP interface [polypeptide binding]; other site 1034809007311 dimer interface [polypeptide binding]; other site 1034809007312 TPP binding site [chemical binding]; other site 1034809007313 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1034809007320 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1034809007322 LexA repressor; Validated; Region: PRK00215 1034809007323 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034809007324 putative DNA binding site [nucleotide binding]; other site 1034809007325 putative Zn2+ binding site [ion binding]; other site 1034809007326 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1034809007327 Catalytic site [active] 1034809007330 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1034809007331 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1034809007333 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1034809007334 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1034809007335 active site 1034809007337 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1034809007340 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1034809007343 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1034809007344 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1034809007345 tetramer interface [polypeptide binding]; other site 1034809007346 heme binding pocket [chemical binding]; other site 1034809007347 NADPH binding site [chemical binding]; other site 1034809007352 lysine transporter; Provisional; Region: PRK10836 1034809007355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809007356 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034809007357 active site 1034809007358 motif I; other site 1034809007359 motif II; other site 1034809007360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809007362 homoserine kinase; Provisional; Region: PRK01212 1034809007363 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1034809007364 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1034809007368 threonine synthase; Reviewed; Region: PRK06721 1034809007369 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1034809007370 homodimer interface [polypeptide binding]; other site 1034809007371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809007372 catalytic residue [active] 1034809007375 homoserine dehydrogenase; Provisional; Region: PRK06349 1034809007376 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1034809007377 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1034809007381 aspartate kinase; Reviewed; Region: PRK09034 1034809007382 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1034809007383 nucleotide binding site [chemical binding]; other site 1034809007384 substrate binding site [chemical binding]; other site 1034809007385 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1034809007386 allosteric regulatory residue; other site 1034809007387 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1034809007394 Staphylococcal nuclease homologues; Region: SNc; smart00318 1034809007395 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1034809007396 Catalytic site; other site 1034809007399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1034809007400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809007401 active site 1034809007402 phosphorylation site [posttranslational modification] 1034809007403 intermolecular recognition site; other site 1034809007404 dimerization interface [polypeptide binding]; other site 1034809007405 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1034809007406 DNA binding residues [nucleotide binding] 1034809007407 dimerization interface [polypeptide binding]; other site 1034809007410 predicted helix-turn-helix motif with score1498.000,SD 4.29 at aa 155-176 1034809007412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1034809007413 Histidine kinase; Region: HisKA_3; pfam07730 1034809007414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809007415 ATP binding site [chemical binding]; other site 1034809007416 Mg2+ binding site [ion binding]; other site 1034809007417 G-X-G motif; other site 1034809007421 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1034809007422 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1034809007424 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034809007425 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1034809007426 Walker A/P-loop; other site 1034809007427 ATP binding site [chemical binding]; other site 1034809007428 Q-loop/lid; other site 1034809007429 ABC transporter signature motif; other site 1034809007430 Walker B; other site 1034809007431 D-loop; other site 1034809007432 H-loop/switch region; other site 1034809007436 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1034809007437 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1034809007438 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1034809007439 putative active site [active] 1034809007440 catalytic site [active] 1034809007441 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1034809007442 putative active site [active] 1034809007443 catalytic site [active] 1034809007447 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1034809007448 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034809007449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034809007450 catalytic residue [active] 1034809007452 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1034809007453 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1034809007454 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1034809007459 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1034809007460 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1034809007461 DNA binding residues [nucleotide binding] 1034809007462 putative dimer interface [polypeptide binding]; other site 1034809007463 predicted helix-turn-helix motif with score1076.000,SD 2.85 at aa 100-121 1034809007465 predicted helix-turn-helix motif with score1030.000,SD 2.70 at aa 13-34 1034809007466 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1034809007467 Aluminium resistance protein; Region: Alum_res; pfam06838 1034809007469 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1034809007470 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1034809007471 HflX GTPase family; Region: HflX; cd01878 1034809007472 G1 box; other site 1034809007473 GTP/Mg2+ binding site [chemical binding]; other site 1034809007474 Switch I region; other site 1034809007475 G2 box; other site 1034809007476 G3 box; other site 1034809007477 Switch II region; other site 1034809007478 G4 box; other site 1034809007479 G5 box; other site 1034809007483 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1034809007484 catalytic residues [active] 1034809007485 dimer interface [polypeptide binding]; other site 1034809007488 bacterial Hfq-like; Region: Hfq; cd01716 1034809007489 hexamer interface [polypeptide binding]; other site 1034809007490 Sm1 motif; other site 1034809007491 RNA binding site [nucleotide binding]; other site 1034809007492 Sm2 motif; other site 1034809007494 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1034809007495 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1034809007498 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1034809007499 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1034809007500 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1034809007505 glycerol kinase; Provisional; Region: glpK; PRK00047 1034809007506 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1034809007507 N- and C-terminal domain interface [polypeptide binding]; other site 1034809007508 active site 1034809007509 MgATP binding site [chemical binding]; other site 1034809007510 catalytic site [active] 1034809007511 metal binding site [ion binding]; metal-binding site 1034809007512 glycerol binding site [chemical binding]; other site 1034809007513 homotetramer interface [polypeptide binding]; other site 1034809007514 homodimer interface [polypeptide binding]; other site 1034809007515 FBP binding site [chemical binding]; other site 1034809007516 protein IIAGlc interface [polypeptide binding]; other site 1034809007521 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1034809007522 amphipathic channel; other site 1034809007523 Asn-Pro-Ala signature motifs; other site 1034809007524 Asn-Pro-Ala signature motifs; other site 1034809007527 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1034809007529 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1034809007530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809007531 ATP binding site [chemical binding]; other site 1034809007532 Mg2+ binding site [ion binding]; other site 1034809007533 G-X-G motif; other site 1034809007534 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1034809007535 ATP binding site [chemical binding]; other site 1034809007536 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1034809007541 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1034809007542 MutS domain I; Region: MutS_I; pfam01624 1034809007543 MutS domain II; Region: MutS_II; pfam05188 1034809007544 MutS domain III; Region: MutS_III; pfam05192 1034809007545 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1034809007546 Walker A/P-loop; other site 1034809007547 ATP binding site [chemical binding]; other site 1034809007548 Q-loop/lid; other site 1034809007549 ABC transporter signature motif; other site 1034809007550 Walker B; other site 1034809007551 D-loop; other site 1034809007552 H-loop/switch region; other site 1034809007560 thiW protein; Region: thiW; TIGR02359 1034809007562 Predicted membrane protein [Function unknown]; Region: COG4550 1034809007563 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1034809007564 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1034809007565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034809007566 FeS/SAM binding site; other site 1034809007567 TRAM domain; Region: TRAM; pfam01938 1034809007572 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1034809007574 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1034809007576 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1034809007577 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1034809007578 TPP-binding site [chemical binding]; other site 1034809007579 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1034809007581 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1034809007582 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1034809007583 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1034809007584 dimer interface [polypeptide binding]; other site 1034809007585 PYR/PP interface [polypeptide binding]; other site 1034809007586 TPP binding site [chemical binding]; other site 1034809007587 substrate binding site [chemical binding]; other site 1034809007590 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1034809007591 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1034809007592 putative active site [active] 1034809007593 metal binding site [ion binding]; metal-binding site 1034809007594 homodimer binding site [polypeptide binding]; other site 1034809007596 phosphodiesterase; Provisional; Region: PRK12704 1034809007597 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034809007598 Zn2+ binding site [ion binding]; other site 1034809007599 Mg2+ binding site [ion binding]; other site 1034809007602 recombinase A; Provisional; Region: recA; PRK09354 1034809007603 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1034809007604 hexamer interface [polypeptide binding]; other site 1034809007605 Walker A motif; other site 1034809007606 ATP binding site [chemical binding]; other site 1034809007607 Walker B motif; other site 1034809007611 competence damage-inducible protein A; Provisional; Region: PRK00549 1034809007612 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1034809007613 putative MPT binding site; other site 1034809007615 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1034809007618 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1034809007619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809007620 non-specific DNA binding site [nucleotide binding]; other site 1034809007621 salt bridge; other site 1034809007622 sequence-specific DNA binding site [nucleotide binding]; other site 1034809007624 predicted helix-turn-helix motif with score993.000,SD 2.57 at aa 17-38 1034809007625 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1034809007626 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1034809007629 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1034809007630 classical (c) SDRs; Region: SDR_c; cd05233 1034809007631 NAD(P) binding site [chemical binding]; other site 1034809007632 active site 1034809007634 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1034809007635 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1034809007636 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1034809007639 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1034809007640 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1034809007642 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1034809007643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034809007644 DNA-binding site [nucleotide binding]; DNA binding site 1034809007645 UTRA domain; Region: UTRA; pfam07702 1034809007648 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1034809007649 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1034809007650 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1034809007654 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1034809007655 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1034809007656 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1034809007659 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1034809007660 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1034809007661 RNase E interface [polypeptide binding]; other site 1034809007662 trimer interface [polypeptide binding]; other site 1034809007663 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1034809007664 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1034809007665 RNase E interface [polypeptide binding]; other site 1034809007666 trimer interface [polypeptide binding]; other site 1034809007667 active site 1034809007668 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1034809007669 putative nucleic acid binding region [nucleotide binding]; other site 1034809007670 G-X-X-G motif; other site 1034809007671 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1034809007672 RNA binding site [nucleotide binding]; other site 1034809007673 domain interface; other site 1034809007681 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1034809007682 16S/18S rRNA binding site [nucleotide binding]; other site 1034809007683 S13e-L30e interaction site [polypeptide binding]; other site 1034809007684 25S rRNA binding site [nucleotide binding]; other site 1034809007687 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1034809007688 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1034809007689 active site 1034809007690 Riboflavin kinase; Region: Flavokinase; pfam01687 1034809007693 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1034809007694 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1034809007695 RNA binding site [nucleotide binding]; other site 1034809007696 active site 1034809007698 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1034809007700 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1034809007701 translation initiation factor IF-2; Region: IF-2; TIGR00487 1034809007702 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1034809007703 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1034809007704 G1 box; other site 1034809007705 putative GEF interaction site [polypeptide binding]; other site 1034809007706 GTP/Mg2+ binding site [chemical binding]; other site 1034809007707 Switch I region; other site 1034809007708 G2 box; other site 1034809007709 G3 box; other site 1034809007710 Switch II region; other site 1034809007711 G4 box; other site 1034809007712 G5 box; other site 1034809007713 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1034809007714 Translation-initiation factor 2; Region: IF-2; pfam11987 1034809007715 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1034809007723 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1034809007725 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1034809007726 putative RNA binding cleft [nucleotide binding]; other site 1034809007728 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1034809007729 NusA N-terminal domain; Region: NusA_N; pfam08529 1034809007730 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1034809007731 RNA binding site [nucleotide binding]; other site 1034809007732 homodimer interface [polypeptide binding]; other site 1034809007733 NusA-like KH domain; Region: KH_5; pfam13184 1034809007734 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1034809007735 G-X-X-G motif; other site 1034809007738 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1034809007739 Sm and related proteins; Region: Sm_like; cl00259 1034809007740 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1034809007741 putative oligomer interface [polypeptide binding]; other site 1034809007742 putative RNA binding site [nucleotide binding]; other site 1034809007744 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1034809007745 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1034809007746 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1034809007747 generic binding surface II; other site 1034809007748 generic binding surface I; other site 1034809007749 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1034809007750 active site 1034809007751 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1034809007752 active site 1034809007753 catalytic site [active] 1034809007754 substrate binding site [chemical binding]; other site 1034809007755 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1034809007760 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1034809007761 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1034809007762 dimer interface [polypeptide binding]; other site 1034809007763 motif 1; other site 1034809007764 active site 1034809007765 motif 2; other site 1034809007766 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1034809007767 putative deacylase active site [active] 1034809007768 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1034809007769 active site 1034809007770 motif 3; other site 1034809007771 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1034809007772 anticodon binding site; other site 1034809007777 RIP metalloprotease RseP; Region: TIGR00054 1034809007778 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1034809007779 active site 1034809007780 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1034809007781 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1034809007782 protein binding site [polypeptide binding]; other site 1034809007783 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1034809007784 putative substrate binding region [chemical binding]; other site 1034809007788 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1034809007789 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1034809007793 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1034809007794 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1034809007797 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1034809007798 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1034809007799 catalytic residue [active] 1034809007800 putative FPP diphosphate binding site; other site 1034809007801 putative FPP binding hydrophobic cleft; other site 1034809007802 dimer interface [polypeptide binding]; other site 1034809007803 putative IPP diphosphate binding site; other site 1034809007806 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1034809007807 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1034809007808 hinge region; other site 1034809007810 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1034809007811 putative nucleotide binding site [chemical binding]; other site 1034809007812 uridine monophosphate binding site [chemical binding]; other site 1034809007813 homohexameric interface [polypeptide binding]; other site 1034809007816 elongation factor Ts; Provisional; Region: tsf; PRK09377 1034809007817 UBA/TS-N domain; Region: UBA; pfam00627 1034809007818 Elongation factor TS; Region: EF_TS; pfam00889 1034809007819 Elongation factor TS; Region: EF_TS; pfam00889 1034809007824 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1034809007825 rRNA interaction site [nucleotide binding]; other site 1034809007826 S8 interaction site; other site 1034809007827 putative laminin-1 binding site; other site 1034809007832 transcriptional repressor CodY; Validated; Region: PRK04158 1034809007833 CodY GAF-like domain; Region: CodY; pfam06018 1034809007834 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1034809007836 predicted helix-turn-helix motif with score1382.000,SD 3.89 at aa 201-222 1034809007838 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1034809007839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809007840 Walker A motif; other site 1034809007841 ATP binding site [chemical binding]; other site 1034809007842 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1034809007843 Walker B motif; other site 1034809007844 arginine finger; other site 1034809007845 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1034809007849 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1034809007850 active site 1034809007851 HslU subunit interaction site [polypeptide binding]; other site 1034809007853 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1034809007854 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1034809007855 active site 1034809007856 DNA binding site [nucleotide binding] 1034809007857 Int/Topo IB signature motif; other site 1034809007860 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1034809007861 Glucose inhibited division protein A; Region: GIDA; pfam01134 1034809007863 DNA topoisomerase I; Validated; Region: PRK05582 1034809007864 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1034809007865 active site 1034809007866 interdomain interaction site; other site 1034809007867 putative metal-binding site [ion binding]; other site 1034809007868 nucleotide binding site [chemical binding]; other site 1034809007869 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1034809007870 domain I; other site 1034809007871 DNA binding groove [nucleotide binding] 1034809007872 phosphate binding site [ion binding]; other site 1034809007873 domain II; other site 1034809007874 domain III; other site 1034809007875 nucleotide binding site [chemical binding]; other site 1034809007876 catalytic site [active] 1034809007877 domain IV; other site 1034809007878 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1034809007879 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1034809007886 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1034809007887 DNA protecting protein DprA; Region: dprA; TIGR00732 1034809007890 FemAB family; Region: FemAB; pfam02388 1034809007892 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1034809007893 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034809007894 CHAP domain; Region: CHAP; pfam05257 1034809007897 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1034809007898 CoA binding domain; Region: CoA_binding; pfam02629 1034809007899 CoA-ligase; Region: Ligase_CoA; pfam00549 1034809007904 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1034809007905 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1034809007906 CoA-ligase; Region: Ligase_CoA; pfam00549 1034809007910 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1034809007911 RNA/DNA hybrid binding site [nucleotide binding]; other site 1034809007912 active site 1034809007914 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1034809007915 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1034809007916 GTP/Mg2+ binding site [chemical binding]; other site 1034809007917 G4 box; other site 1034809007918 G5 box; other site 1034809007919 G1 box; other site 1034809007920 Switch I region; other site 1034809007921 G2 box; other site 1034809007922 G3 box; other site 1034809007923 Switch II region; other site 1034809007926 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1034809007929 Predicted membrane protein [Function unknown]; Region: COG4485 1034809007931 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1034809007934 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1034809007936 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1034809007937 RimM N-terminal domain; Region: RimM; pfam01782 1034809007938 PRC-barrel domain; Region: PRC; pfam05239 1034809007941 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1034809007943 predicted helix-turn-helix motif with score1298.000,SD 3.61 at aa 73-94 1034809007944 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1034809007945 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1034809007946 dimer interface [polypeptide binding]; other site 1034809007947 active site 1034809007952 acyl-CoA synthetase; Validated; Region: PRK07638 1034809007953 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1034809007954 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1034809007955 acyl-activating enzyme (AAE) consensus motif; other site 1034809007956 acyl-activating enzyme (AAE) consensus motif; other site 1034809007957 AMP binding site [chemical binding]; other site 1034809007958 active site 1034809007959 CoA binding site [chemical binding]; other site 1034809007963 signal recognition particle protein; Provisional; Region: PRK10867 1034809007964 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1034809007965 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1034809007966 P loop; other site 1034809007967 GTP binding site [chemical binding]; other site 1034809007968 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1034809007974 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1034809007975 putative DNA-binding protein; Validated; Region: PRK00118 1034809007977 predicted helix-turn-helix motif with score1606.000,SD 4.66 at aa 39-60 1034809007978 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1034809007979 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1034809007980 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1034809007981 P loop; other site 1034809007982 GTP binding site [chemical binding]; other site 1034809007988 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1034809007989 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1034809007990 Walker A/P-loop; other site 1034809007991 ATP binding site [chemical binding]; other site 1034809007992 Q-loop/lid; other site 1034809007993 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1034809007994 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1034809007995 ABC transporter signature motif; other site 1034809007996 Walker B; other site 1034809007997 D-loop; other site 1034809007998 H-loop/switch region; other site 1034809008002 ribonuclease III; Reviewed; Region: rnc; PRK00102 1034809008003 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1034809008004 dimerization interface [polypeptide binding]; other site 1034809008005 active site 1034809008006 metal binding site [ion binding]; metal-binding site 1034809008007 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1034809008008 dsRNA binding site [nucleotide binding]; other site 1034809008012 acyl carrier protein; Provisional; Region: acpP; PRK00982 1034809008016 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1034809008017 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1034809008018 NAD(P) binding site [chemical binding]; other site 1034809008019 homotetramer interface [polypeptide binding]; other site 1034809008020 homodimer interface [polypeptide binding]; other site 1034809008021 active site 1034809008024 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1034809008025 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1034809008027 putative phosphate acyltransferase; Provisional; Region: PRK05331 1034809008030 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1034809008031 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1034809008032 active site 2 [active] 1034809008033 active site 1 [active] 1034809008034 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1034809008035 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1034809008036 generic binding surface II; other site 1034809008037 ssDNA binding site; other site 1034809008038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034809008039 ATP binding site [chemical binding]; other site 1034809008040 putative Mg++ binding site [ion binding]; other site 1034809008041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034809008042 nucleotide binding region [chemical binding]; other site 1034809008043 ATP-binding site [chemical binding]; other site 1034809008049 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1034809008050 DAK2 domain; Region: Dak2; pfam02734 1034809008052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1034809008054 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1034809008056 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1034809008057 Thiamine pyrophosphokinase; Region: TPK; cd07995 1034809008058 active site 1034809008059 dimerization interface [polypeptide binding]; other site 1034809008060 thiamine binding site [chemical binding]; other site 1034809008063 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1034809008064 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1034809008065 substrate binding site [chemical binding]; other site 1034809008066 hexamer interface [polypeptide binding]; other site 1034809008067 metal binding site [ion binding]; metal-binding site 1034809008072 GTPase RsgA; Reviewed; Region: PRK00098 1034809008073 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1034809008074 RNA binding site [nucleotide binding]; other site 1034809008075 homodimer interface [polypeptide binding]; other site 1034809008076 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1034809008077 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1034809008078 GTP/Mg2+ binding site [chemical binding]; other site 1034809008079 G4 box; other site 1034809008080 G5 box; other site 1034809008081 G1 box; other site 1034809008082 Switch I region; other site 1034809008083 G2 box; other site 1034809008084 G3 box; other site 1034809008085 Switch II region; other site 1034809008089 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1034809008090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1034809008091 active site 1034809008092 ATP binding site [chemical binding]; other site 1034809008093 substrate binding site [chemical binding]; other site 1034809008094 activation loop (A-loop); other site 1034809008095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1034809008096 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1034809008097 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1034809008098 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1034809008105 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1034809008106 Protein phosphatase 2C; Region: PP2C; pfam00481 1034809008107 active site 1034809008109 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1034809008110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034809008111 FeS/SAM binding site; other site 1034809008113 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1034809008114 NusB family; Region: NusB; pfam01029 1034809008115 putative RNA binding site [nucleotide binding]; other site 1034809008116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809008117 S-adenosylmethionine binding site [chemical binding]; other site 1034809008120 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1034809008121 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1034809008122 putative active site [active] 1034809008123 substrate binding site [chemical binding]; other site 1034809008124 putative cosubstrate binding site; other site 1034809008125 catalytic site [active] 1034809008126 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1034809008127 substrate binding site [chemical binding]; other site 1034809008131 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1034809008132 active site 1034809008133 catalytic residues [active] 1034809008134 metal binding site [ion binding]; metal-binding site 1034809008136 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1034809008137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034809008138 ATP binding site [chemical binding]; other site 1034809008139 putative Mg++ binding site [ion binding]; other site 1034809008140 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1034809008141 nucleotide binding region [chemical binding]; other site 1034809008142 ATP-binding site [chemical binding]; other site 1034809008146 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1034809008147 Flavoprotein; Region: Flavoprotein; pfam02441 1034809008148 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1034809008151 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1034809008153 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1034809008154 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1034809008155 catalytic site [active] 1034809008156 G-X2-G-X-G-K; other site 1034809008159 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1034809008160 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1034809008163 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1034809008164 dimer interface [polypeptide binding]; other site 1034809008166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809008167 active site 1034809008172 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1034809008173 active site 1034809008174 dimer interface [polypeptide binding]; other site 1034809008177 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1034809008178 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034809008179 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1034809008180 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1034809008181 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034809008182 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1034809008183 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1034809008184 IMP binding site; other site 1034809008185 dimer interface [polypeptide binding]; other site 1034809008186 interdomain contacts; other site 1034809008187 partial ornithine binding site; other site 1034809008199 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1034809008200 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1034809008201 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1034809008202 catalytic site [active] 1034809008203 subunit interface [polypeptide binding]; other site 1034809008207 dihydroorotase; Validated; Region: pyrC; PRK09357 1034809008208 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1034809008209 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1034809008210 active site 1034809008214 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1034809008215 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1034809008216 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1034809008220 uracil transporter; Provisional; Region: PRK10720 1034809008223 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1034809008224 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809008225 active site 1034809008227 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1034809008228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034809008229 RNA binding surface [nucleotide binding]; other site 1034809008230 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1034809008231 active site 1034809008235 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1034809008236 lipoprotein signal peptidase; Provisional; Region: PRK14787 1034809008239 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1034809008240 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1034809008241 active site 1034809008243 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1034809008244 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1034809008245 HIGH motif; other site 1034809008246 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1034809008247 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1034809008248 active site 1034809008249 KMSKS motif; other site 1034809008250 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1034809008251 tRNA binding surface [nucleotide binding]; other site 1034809008252 anticodon binding site; other site 1034809008253 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1034809008258 DivIVA protein; Region: DivIVA; pfam05103 1034809008259 DivIVA domain; Region: DivI1A_domain; TIGR03544 1034809008261 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1034809008262 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034809008263 RNA binding surface [nucleotide binding]; other site 1034809008265 YGGT family; Region: YGGT; pfam02325 1034809008267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1034809008269 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1034809008270 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1034809008271 catalytic residue [active] 1034809008273 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1034809008274 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1034809008276 cell division protein FtsZ; Validated; Region: PRK09330 1034809008277 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1034809008278 nucleotide binding site [chemical binding]; other site 1034809008279 SulA interaction site; other site 1034809008284 cell division protein FtsA; Region: ftsA; TIGR01174 1034809008285 Cell division protein FtsA; Region: FtsA; smart00842 1034809008286 Cell division protein FtsA; Region: FtsA; pfam14450 1034809008289 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1034809008290 Cell division protein FtsQ; Region: FtsQ; pfam03799 1034809008294 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1034809008295 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1034809008296 NAD binding site [chemical binding]; other site 1034809008297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034809008298 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034809008301 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1034809008302 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1034809008303 Mg++ binding site [ion binding]; other site 1034809008304 putative catalytic motif [active] 1034809008305 putative substrate binding site [chemical binding]; other site 1034809008308 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1034809008309 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1034809008310 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1034809008311 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1034809008312 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1034809008319 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1034809008321 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1034809008322 MraW methylase family; Region: Methyltransf_5; pfam01795 1034809008324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1034809008325 MraZ protein; Region: MraZ; pfam02381 1034809008326 MraZ protein; Region: MraZ; pfam02381 1034809008329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1034809008330 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1034809008332 hypothetical protein; Provisional; Region: PRK13688 1034809008333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809008334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1034809008335 Coenzyme A binding pocket [chemical binding]; other site 1034809008337 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1034809008338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809008339 motif II; other site 1034809008341 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1034809008342 active site 1034809008343 metal binding site [ion binding]; metal-binding site 1034809008344 homotetramer interface [polypeptide binding]; other site 1034809008346 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1034809008347 active site 1034809008348 dimerization interface [polypeptide binding]; other site 1034809008350 glutamate racemase; Provisional; Region: PRK00865 1034809008354 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1034809008355 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1034809008358 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1034809008359 L-aspartate oxidase; Provisional; Region: PRK06175 1034809008360 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1034809008364 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1034809008365 putative Iron-sulfur protein interface [polypeptide binding]; other site 1034809008366 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1034809008367 proximal heme binding site [chemical binding]; other site 1034809008368 distal heme binding site [chemical binding]; other site 1034809008369 putative dimer interface [polypeptide binding]; other site 1034809008371 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1034809008372 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1034809008373 GIY-YIG motif/motif A; other site 1034809008374 active site 1034809008375 catalytic site [active] 1034809008376 putative DNA binding site [nucleotide binding]; other site 1034809008377 metal binding site [ion binding]; metal-binding site 1034809008378 UvrB/uvrC motif; Region: UVR; pfam02151 1034809008379 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1034809008383 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034809008384 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1034809008385 catalytic residues [active] 1034809008388 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1034809008389 MutS domain III; Region: MutS_III; pfam05192 1034809008390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809008391 Walker A/P-loop; other site 1034809008392 ATP binding site [chemical binding]; other site 1034809008393 Q-loop/lid; other site 1034809008394 ABC transporter signature motif; other site 1034809008395 Walker B; other site 1034809008396 D-loop; other site 1034809008397 H-loop/switch region; other site 1034809008398 Smr domain; Region: Smr; pfam01713 1034809008402 hypothetical protein; Provisional; Region: PRK08609 1034809008403 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1034809008404 active site 1034809008405 primer binding site [nucleotide binding]; other site 1034809008406 NTP binding site [chemical binding]; other site 1034809008407 metal binding triad [ion binding]; metal-binding site 1034809008408 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1034809008409 active site 1034809008411 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1034809008412 Colicin V production protein; Region: Colicin_V; pfam02674 1034809008414 Cell division protein ZapA; Region: ZapA; cl01146 1034809008416 ribonuclease HIII; Provisional; Region: PRK00996 1034809008417 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1034809008418 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1034809008419 RNA/DNA hybrid binding site [nucleotide binding]; other site 1034809008420 active site 1034809008422 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1034809008423 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1034809008424 putative tRNA-binding site [nucleotide binding]; other site 1034809008425 B3/4 domain; Region: B3_4; pfam03483 1034809008426 tRNA synthetase B5 domain; Region: B5; smart00874 1034809008427 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1034809008428 dimer interface [polypeptide binding]; other site 1034809008429 motif 1; other site 1034809008430 motif 3; other site 1034809008431 motif 2; other site 1034809008432 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1034809008437 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1034809008438 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1034809008439 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1034809008440 dimer interface [polypeptide binding]; other site 1034809008441 motif 1; other site 1034809008442 active site 1034809008443 motif 2; other site 1034809008444 motif 3; other site 1034809008449 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1034809008450 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1034809008451 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1034809008454 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1034809008456 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1034809008458 hypothetical protein; Provisional; Region: PRK13670 1034809008459 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1034809008463 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1034809008464 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1034809008465 active site 1034809008466 (T/H)XGH motif; other site 1034809008469 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1034809008470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809008471 S-adenosylmethionine binding site [chemical binding]; other site 1034809008474 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1034809008476 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1034809008477 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1034809008478 putative active site [active] 1034809008479 catalytic site [active] 1034809008480 putative metal binding site [ion binding]; other site 1034809008482 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1034809008484 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1034809008485 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1034809008487 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1034809008490 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1034809008491 UbiA prenyltransferase family; Region: UbiA; pfam01040 1034809008494 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1034809008495 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1034809008498 pyruvate carboxylase; Reviewed; Region: PRK12999 1034809008499 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1034809008500 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1034809008501 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1034809008502 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1034809008503 active site 1034809008504 catalytic residues [active] 1034809008505 metal binding site [ion binding]; metal-binding site 1034809008506 homodimer binding site [polypeptide binding]; other site 1034809008507 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1034809008508 carboxyltransferase (CT) interaction site; other site 1034809008509 biotinylation site [posttranslational modification]; other site 1034809008518 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1034809008520 hypothetical protein; Provisional; Region: PRK13666 1034809008522 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1034809008524 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1034809008525 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1034809008526 G1 box; other site 1034809008527 putative GEF interaction site [polypeptide binding]; other site 1034809008528 GTP/Mg2+ binding site [chemical binding]; other site 1034809008529 Switch I region; other site 1034809008530 G2 box; other site 1034809008531 G3 box; other site 1034809008532 Switch II region; other site 1034809008533 G4 box; other site 1034809008534 G5 box; other site 1034809008535 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1034809008536 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1034809008542 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1034809008543 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1034809008544 active site 1034809008548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1034809008549 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1034809008551 manganese transport protein MntH; Reviewed; Region: PRK00701 1034809008552 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1034809008554 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1034809008555 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1034809008556 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1034809008557 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1034809008558 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1034809008560 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1034809008561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809008562 dimer interface [polypeptide binding]; other site 1034809008563 conserved gate region; other site 1034809008564 putative PBP binding loops; other site 1034809008565 ABC-ATPase subunit interface; other site 1034809008567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809008568 dimer interface [polypeptide binding]; other site 1034809008569 conserved gate region; other site 1034809008570 putative PBP binding loops; other site 1034809008571 ABC-ATPase subunit interface; other site 1034809008573 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1034809008574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809008575 Walker A/P-loop; other site 1034809008576 ATP binding site [chemical binding]; other site 1034809008577 Q-loop/lid; other site 1034809008578 ABC transporter signature motif; other site 1034809008579 Walker B; other site 1034809008580 D-loop; other site 1034809008581 H-loop/switch region; other site 1034809008582 TOBE domain; Region: TOBE_2; pfam08402 1034809008587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809008588 sequence-specific DNA binding site [nucleotide binding]; other site 1034809008589 salt bridge; other site 1034809008590 Cupin domain; Region: Cupin_2; pfam07883 1034809008593 predicted helix-turn-helix motif with score1918.000,SD 5.72 at aa 16-37 1034809008594 hypothetical protein; Provisional; Region: PRK04387 1034809008596 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1034809008597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1034809008598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809008599 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034809008603 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1034809008604 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1034809008605 E3 interaction surface; other site 1034809008606 lipoyl attachment site [posttranslational modification]; other site 1034809008607 e3 binding domain; Region: E3_binding; pfam02817 1034809008608 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1034809008613 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1034809008614 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1034809008615 alpha subunit interface [polypeptide binding]; other site 1034809008616 TPP binding site [chemical binding]; other site 1034809008617 heterodimer interface [polypeptide binding]; other site 1034809008618 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1034809008621 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1034809008622 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1034809008623 TPP-binding site [chemical binding]; other site 1034809008624 tetramer interface [polypeptide binding]; other site 1034809008625 heterodimer interface [polypeptide binding]; other site 1034809008626 phosphorylation loop region [posttranslational modification] 1034809008628 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1034809008631 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1034809008632 active site 1034809008633 catalytic residues [active] 1034809008634 metal binding site [ion binding]; metal-binding site 1034809008636 hypothetical protein; Provisional; Region: PRK13667 1034809008638 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1034809008639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1034809008640 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1034809008646 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1034809008647 TrkA-N domain; Region: TrkA_N; pfam02254 1034809008648 TrkA-C domain; Region: TrkA_C; pfam02080 1034809008651 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1034809008653 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1034809008654 catalytic residues [active] 1034809008656 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1034809008657 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1034809008658 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1034809008659 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1034809008665 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1034809008666 dimerization domain swap beta strand [polypeptide binding]; other site 1034809008667 regulatory protein interface [polypeptide binding]; other site 1034809008668 active site 1034809008669 regulatory phosphorylation site [posttranslational modification]; other site 1034809008673 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1034809008674 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 1034809008675 putative RNA binding site [nucleotide binding]; other site 1034809008676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809008677 S-adenosylmethionine binding site [chemical binding]; other site 1034809008678 predicted helix-turn-helix motif with score975.000,SD 2.51 at aa 222-243 1034809008679 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1034809008681 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1034809008682 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1034809008683 Walker A/P-loop; other site 1034809008684 ATP binding site [chemical binding]; other site 1034809008685 Q-loop/lid; other site 1034809008686 ABC transporter signature motif; other site 1034809008687 Walker B; other site 1034809008688 D-loop; other site 1034809008689 H-loop/switch region; other site 1034809008690 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1034809008691 Walker A/P-loop; other site 1034809008692 ATP binding site [chemical binding]; other site 1034809008693 ABC transporter; Region: ABC_tran; pfam00005 1034809008694 Q-loop/lid; other site 1034809008695 ABC transporter signature motif; other site 1034809008696 Walker B; other site 1034809008697 D-loop; other site 1034809008698 H-loop/switch region; other site 1034809008704 CDS contains a frameshift after residue 141 1034809008705 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1034809008706 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1034809008707 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1034809008708 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1034809008713 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1034809008714 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1034809008715 purine monophosphate binding site [chemical binding]; other site 1034809008716 dimer interface [polypeptide binding]; other site 1034809008717 putative catalytic residues [active] 1034809008718 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1034809008719 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1034809008722 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1034809008723 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1034809008724 active site 1034809008725 substrate binding site [chemical binding]; other site 1034809008726 cosubstrate binding site; other site 1034809008727 catalytic site [active] 1034809008729 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1034809008730 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1034809008731 dimerization interface [polypeptide binding]; other site 1034809008732 putative ATP binding site [chemical binding]; other site 1034809008735 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1034809008736 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1034809008737 active site 1034809008738 tetramer interface [polypeptide binding]; other site 1034809008739 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809008740 active site 1034809008741 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1034809008746 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1034809008747 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1034809008748 dimerization interface [polypeptide binding]; other site 1034809008749 ATP binding site [chemical binding]; other site 1034809008750 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1034809008751 dimerization interface [polypeptide binding]; other site 1034809008752 ATP binding site [chemical binding]; other site 1034809008757 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1034809008758 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1034809008759 putative active site [active] 1034809008760 catalytic triad [active] 1034809008762 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1034809008764 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1034809008765 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1034809008766 ATP binding site [chemical binding]; other site 1034809008767 active site 1034809008768 substrate binding site [chemical binding]; other site 1034809008772 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1034809008773 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1034809008774 ATP-grasp domain; Region: ATP-grasp; pfam02222 1034809008776 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1034809008779 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1034809008780 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1034809008781 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1034809008782 homodimer interface [polypeptide binding]; other site 1034809008783 NADP binding site [chemical binding]; other site 1034809008784 substrate binding site [chemical binding]; other site 1034809008787 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1034809008788 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1034809008789 heme-binding site [chemical binding]; other site 1034809008790 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1034809008791 FAD binding pocket [chemical binding]; other site 1034809008792 conserved FAD binding motif [chemical binding]; other site 1034809008793 phosphate binding motif [ion binding]; other site 1034809008794 beta-alpha-beta structure motif; other site 1034809008795 NAD binding pocket [chemical binding]; other site 1034809008798 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1034809008799 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1034809008800 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1034809008801 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1034809008802 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1034809008807 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1034809008808 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1034809008809 D-pathway; other site 1034809008810 Putative ubiquinol binding site [chemical binding]; other site 1034809008811 Low-spin heme (heme b) binding site [chemical binding]; other site 1034809008812 Putative water exit pathway; other site 1034809008813 Binuclear center (heme o3/CuB) [ion binding]; other site 1034809008814 K-pathway; other site 1034809008815 Putative proton exit pathway; other site 1034809008819 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1034809008820 Subunit I/III interface [polypeptide binding]; other site 1034809008821 Subunit III/IV interface [polypeptide binding]; other site 1034809008823 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1034809008825 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1034809008826 active site 1034809008827 tetramer interface [polypeptide binding]; other site 1034809008829 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1034809008830 Beta-lactamase; Region: Beta-lactamase; pfam00144 1034809008832 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1034809008834 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1034809008835 Autoinducer synthetase; Region: Autoind_synth; cl17404 1034809008836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809008837 Coenzyme A binding pocket [chemical binding]; other site 1034809008839 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1034809008840 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1034809008841 amidase catalytic site [active] 1034809008842 Zn binding residues [ion binding]; other site 1034809008843 substrate binding site [chemical binding]; other site 1034809008844 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1034809008845 Lysozyme subfamily 2; Region: LYZ2; smart00047 1034809008848 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034809008849 MarR family; Region: MarR; pfam01047 1034809008851 predicted helix-turn-helix motif with score1295.000,SD 3.60 at aa 46-67 1034809008852 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1034809008853 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1034809008855 aminotransferase A; Validated; Region: PRK07683 1034809008856 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034809008857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809008858 homodimer interface [polypeptide binding]; other site 1034809008859 catalytic residue [active] 1034809008862 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1034809008863 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1034809008864 substrate binding site [chemical binding]; other site 1034809008865 oxyanion hole (OAH) forming residues; other site 1034809008866 trimer interface [polypeptide binding]; other site 1034809008869 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1034809008872 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1034809008873 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1034809008874 dimer interface [polypeptide binding]; other site 1034809008875 tetramer interface [polypeptide binding]; other site 1034809008876 PYR/PP interface [polypeptide binding]; other site 1034809008877 TPP binding site [chemical binding]; other site 1034809008878 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1034809008879 TPP-binding site; other site 1034809008881 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1034809008882 isochorismate synthases; Region: isochor_syn; TIGR00543 1034809008884 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1034809008885 UbiA prenyltransferase family; Region: UbiA; pfam01040 1034809008889 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1034809008891 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1034809008892 ComK protein; Region: ComK; cl11560 1034809008894 IDEAL domain; Region: IDEAL; pfam08858 1034809008895 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1034809008896 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1034809008897 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1034809008900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1034809008902 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1034809008903 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1034809008904 active site 1034809008905 metal binding site [ion binding]; metal-binding site 1034809008906 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1034809008908 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1034809008909 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1034809008911 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1034809008912 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1034809008913 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1034809008914 protein binding site [polypeptide binding]; other site 1034809008916 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1034809008918 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1034809008919 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1034809008920 G1 box; other site 1034809008921 putative GEF interaction site [polypeptide binding]; other site 1034809008922 GTP/Mg2+ binding site [chemical binding]; other site 1034809008923 Switch I region; other site 1034809008924 G2 box; other site 1034809008925 G3 box; other site 1034809008926 Switch II region; other site 1034809008927 G4 box; other site 1034809008928 G5 box; other site 1034809008929 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1034809008933 YueH-like protein; Region: YueH; pfam14166 1034809008934 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1034809008935 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1034809008936 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1034809008937 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1034809008941 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1034809008942 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1034809008943 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1034809008946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809008947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809008948 putative substrate translocation pore; other site 1034809008951 hypothetical protein; Provisional; Region: PRK13679 1034809008952 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1034809008954 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1034809008955 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1034809008956 DNA binding residues [nucleotide binding] 1034809008957 predicted helix-turn-helix motif with score1760.000,SD 5.18 at aa 2-23 1034809008959 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1034809008960 classical (c) SDRs; Region: SDR_c; cd05233 1034809008961 NAD(P) binding site [chemical binding]; other site 1034809008962 active site 1034809008964 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1034809008965 Putative esterase; Region: Esterase; pfam00756 1034809008967 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1034809008968 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1034809008970 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1034809008971 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1034809008972 NAD binding site [chemical binding]; other site 1034809008973 homotetramer interface [polypeptide binding]; other site 1034809008974 homodimer interface [polypeptide binding]; other site 1034809008975 substrate binding site [chemical binding]; other site 1034809008976 active site 1034809008977 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1034809008978 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1034809008979 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1034809008980 TrkA-N domain; Region: TrkA_N; pfam02254 1034809008981 TrkA-C domain; Region: TrkA_C; pfam02080 1034809008986 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1034809008987 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1034809008988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1034809008989 Divalent cation transporter; Region: MgtE; cl00786 1034809008990 Divalent cation transporter; Region: MgtE; cl00786 1034809008993 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1034809008994 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034809008995 RNA binding surface [nucleotide binding]; other site 1034809008996 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1034809008997 active site 1034809009000 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1034809009001 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1034809009003 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1034809009004 synthetase active site [active] 1034809009005 NTP binding site [chemical binding]; other site 1034809009006 metal binding site [ion binding]; metal-binding site 1034809009008 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1034809009009 putative active site [active] 1034809009010 putative metal binding residues [ion binding]; other site 1034809009011 signature motif; other site 1034809009012 putative triphosphate binding site [ion binding]; other site 1034809009014 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1034809009015 apolar tunnel; other site 1034809009016 heme binding site [chemical binding]; other site 1034809009017 dimerization interface [polypeptide binding]; other site 1034809009019 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1034809009020 Thioredoxin; Region: Thioredoxin_5; pfam13743 1034809009021 oligoendopeptidase F; Region: pepF; TIGR00181 1034809009022 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1034809009023 active site 1034809009024 Zn binding site [ion binding]; other site 1034809009027 Competence protein CoiA-like family; Region: CoiA; pfam06054 1034809009029 adaptor protein; Provisional; Region: PRK02315 1034809009031 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1034809009032 ArsC family; Region: ArsC; pfam03960 1034809009033 putative catalytic residues [active] 1034809009034 thiol/disulfide switch; other site 1034809009036 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1034809009037 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1034809009038 active site 1034809009039 HIGH motif; other site 1034809009040 dimer interface [polypeptide binding]; other site 1034809009041 KMSKS motif; other site 1034809009044 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1034809009045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809009046 S-adenosylmethionine binding site [chemical binding]; other site 1034809009048 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1034809009049 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1034809009050 peptide binding site [polypeptide binding]; other site 1034809009053 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1034809009054 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1034809009055 Walker A/P-loop; other site 1034809009056 ATP binding site [chemical binding]; other site 1034809009057 Q-loop/lid; other site 1034809009058 ABC transporter signature motif; other site 1034809009059 Walker B; other site 1034809009060 D-loop; other site 1034809009061 H-loop/switch region; other site 1034809009062 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034809009067 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1034809009068 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1034809009069 Walker A/P-loop; other site 1034809009070 ATP binding site [chemical binding]; other site 1034809009071 Q-loop/lid; other site 1034809009072 ABC transporter signature motif; other site 1034809009073 Walker B; other site 1034809009074 D-loop; other site 1034809009075 H-loop/switch region; other site 1034809009076 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1034809009081 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1034809009082 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1034809009083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809009084 dimer interface [polypeptide binding]; other site 1034809009085 conserved gate region; other site 1034809009086 putative PBP binding loops; other site 1034809009087 ABC-ATPase subunit interface; other site 1034809009089 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1034809009090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809009091 dimer interface [polypeptide binding]; other site 1034809009092 ABC-ATPase subunit interface; other site 1034809009093 putative PBP binding loops; other site 1034809009095 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1034809009096 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1034809009097 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1034809009098 dimer interface [polypeptide binding]; other site 1034809009099 active site 1034809009102 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1034809009103 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1034809009104 dimer interface [polypeptide binding]; other site 1034809009105 active site 1034809009106 CoA binding pocket [chemical binding]; other site 1034809009109 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1034809009110 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1034809009111 Clp amino terminal domain; Region: Clp_N; pfam02861 1034809009112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809009113 Walker A motif; other site 1034809009114 ATP binding site [chemical binding]; other site 1034809009115 Walker B motif; other site 1034809009116 arginine finger; other site 1034809009117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809009118 Walker A motif; other site 1034809009119 ATP binding site [chemical binding]; other site 1034809009120 Walker B motif; other site 1034809009121 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1034809009131 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1034809009134 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034809009135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809009136 motif II; other site 1034809009137 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1034809009140 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1034809009141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809009142 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034809009145 hypothetical protein; Provisional; Region: PRK13673 1034809009147 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1034809009148 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1034809009150 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1034809009151 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1034809009152 Family description; Region: UvrD_C_2; pfam13538 1034809009153 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1034809009156 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1034809009157 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1034809009159 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1034809009160 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1034809009161 Catalytic site [active] 1034809009167 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1034809009168 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1034809009170 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1034809009171 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1034809009172 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1034809009173 active site 1034809009174 dimer interface [polypeptide binding]; other site 1034809009175 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1034809009176 dimer interface [polypeptide binding]; other site 1034809009177 active site 1034809009180 argininosuccinate synthase; Provisional; Region: PRK13820 1034809009181 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1034809009182 ANP binding site [chemical binding]; other site 1034809009183 Substrate Binding Site II [chemical binding]; other site 1034809009184 Substrate Binding Site I [chemical binding]; other site 1034809009189 argininosuccinate lyase; Provisional; Region: PRK00855 1034809009190 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1034809009191 active sites [active] 1034809009192 tetramer interface [polypeptide binding]; other site 1034809009195 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1034809009196 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1034809009197 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1034809009198 NAD(P) binding site [chemical binding]; other site 1034809009202 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1034809009203 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1034809009204 putative active site [active] 1034809009205 putative FMN binding site [chemical binding]; other site 1034809009206 putative substrate binding site [chemical binding]; other site 1034809009207 putative catalytic residue [active] 1034809009209 general stress protein 13; Validated; Region: PRK08059 1034809009210 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1034809009211 RNA binding site [nucleotide binding]; other site 1034809009213 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1034809009214 active site 1034809009217 Kinase associated protein B; Region: KapB; pfam08810 1034809009219 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1034809009220 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1034809009221 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1034809009222 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1034809009226 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1034809009228 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1034809009230 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1034809009231 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1034809009234 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1034809009236 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1034809009238 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1034809009240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1034809009241 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1034809009242 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1034809009243 CoenzymeA binding site [chemical binding]; other site 1034809009244 subunit interaction site [polypeptide binding]; other site 1034809009245 PHB binding site; other site 1034809009247 Predicted permease [General function prediction only]; Region: COG2056 1034809009248 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1034809009249 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1034809009251 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1034809009252 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1034809009253 interface (dimer of trimers) [polypeptide binding]; other site 1034809009254 Substrate-binding/catalytic site; other site 1034809009255 Zn-binding sites [ion binding]; other site 1034809009257 predicted helix-turn-helix motif with score1087.000,SD 2.89 at aa 420-441 1034809009259 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1034809009260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809009262 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1034809009264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034809009265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1034809009266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809009267 Walker A/P-loop; other site 1034809009268 ATP binding site [chemical binding]; other site 1034809009269 Q-loop/lid; other site 1034809009270 ABC transporter signature motif; other site 1034809009271 Walker B; other site 1034809009272 D-loop; other site 1034809009273 H-loop/switch region; other site 1034809009278 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034809009279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1034809009280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809009281 Walker A/P-loop; other site 1034809009282 ATP binding site [chemical binding]; other site 1034809009283 Q-loop/lid; other site 1034809009284 ABC transporter signature motif; other site 1034809009285 Walker B; other site 1034809009286 D-loop; other site 1034809009287 H-loop/switch region; other site 1034809009293 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1034809009294 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1034809009295 Walker A/P-loop; other site 1034809009296 ATP binding site [chemical binding]; other site 1034809009297 Q-loop/lid; other site 1034809009298 ABC transporter signature motif; other site 1034809009299 Walker B; other site 1034809009300 D-loop; other site 1034809009301 H-loop/switch region; other site 1034809009302 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1034809009303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809009304 Walker A/P-loop; other site 1034809009305 ATP binding site [chemical binding]; other site 1034809009306 Q-loop/lid; other site 1034809009307 ABC transporter signature motif; other site 1034809009308 Walker B; other site 1034809009309 D-loop; other site 1034809009310 H-loop/switch region; other site 1034809009316 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1034809009319 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 1034809009321 Condensation domain; Region: Condensation; pfam00668 1034809009322 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034809009323 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1034809009327 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1034809009328 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1034809009329 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 1034809009330 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1034809009333 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1034809009334 Condensation domain; Region: Condensation; pfam00668 1034809009335 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034809009336 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1034809009337 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1034809009338 acyl-activating enzyme (AAE) consensus motif; other site 1034809009339 AMP binding site [chemical binding]; other site 1034809009340 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1034809009341 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809009342 Condensation domain; Region: Condensation; pfam00668 1034809009343 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1034809009344 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1034809009345 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1034809009358 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1034809009359 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1034809009360 acyl-activating enzyme (AAE) consensus motif; other site 1034809009361 active site 1034809009362 AMP binding site [chemical binding]; other site 1034809009363 substrate binding site [chemical binding]; other site 1034809009366 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1034809009367 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1034809009369 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1034809009371 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1034809009374 hypothetical protein; Provisional; Region: PRK13669 1034809009376 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1034809009377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809009379 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1034809009381 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1034809009383 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1034809009384 DltD N-terminal region; Region: DltD_N; pfam04915 1034809009385 DltD central region; Region: DltD_M; pfam04918 1034809009386 DltD C-terminal region; Region: DltD_C; pfam04914 1034809009390 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1034809009391 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1034809009393 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1034809009394 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1034809009395 acyl-activating enzyme (AAE) consensus motif; other site 1034809009396 AMP binding site [chemical binding]; other site 1034809009399 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1034809009400 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1034809009401 dimerization interface [polypeptide binding]; other site 1034809009402 ligand binding site [chemical binding]; other site 1034809009403 NADP binding site [chemical binding]; other site 1034809009404 catalytic site [active] 1034809009409 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1034809009410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809009411 active site 1034809009412 motif I; other site 1034809009413 motif II; other site 1034809009414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809009416 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1034809009418 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1034809009419 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1034809009421 lipoyl synthase; Provisional; Region: PRK05481 1034809009422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1034809009423 FeS/SAM binding site; other site 1034809009425 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1034809009426 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1034809009427 active site 1034809009428 metal binding site [ion binding]; metal-binding site 1034809009429 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1034809009431 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1034809009433 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1034809009435 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1034809009436 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1034809009437 FMN binding site [chemical binding]; other site 1034809009438 substrate binding site [chemical binding]; other site 1034809009439 putative catalytic residue [active] 1034809009441 Domain of unknown function DUF21; Region: DUF21; pfam01595 1034809009442 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1034809009449 Protein of unknown function, DUF600; Region: DUF600; cl04640 1034809009451 CDS contains a frameshift after residue 137 1034809009452 Protein of unknown function, DUF600; Region: DUF600; cl04640 1034809009453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034809009454 dimerization interface [polypeptide binding]; other site 1034809009455 putative DNA binding site [nucleotide binding]; other site 1034809009456 putative Zn2+ binding site [ion binding]; other site 1034809009457 CDS contains a frameshift after residue 109 1034809009458 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1034809009459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809009460 S-adenosylmethionine binding site [chemical binding]; other site 1034809009461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1034809009462 Protein of unknown function, DUF600; Region: DUF600; cl04640 1034809009463 Protein of unknown function, DUF600; Region: DUF600; cl04640 1034809009466 LXG domain of WXG superfamily; Region: LXG; pfam04740 1034809009467 CDS contains a frameshift after residue 1373 1034809009471 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1034809009472 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1034809009474 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1034809009476 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 1034809009478 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1034809009479 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1034809009480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1034809009482 Surface antigen [General function prediction only]; Region: COG3942 1034809009483 CHAP domain; Region: CHAP; pfam05257 1034809009487 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1034809009488 FeS assembly protein SufB; Region: sufB; TIGR01980 1034809009490 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1034809009491 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1034809009492 trimerization site [polypeptide binding]; other site 1034809009493 active site 1034809009495 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1034809009496 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1034809009497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034809009498 catalytic residue [active] 1034809009501 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1034809009502 FeS assembly protein SufD; Region: sufD; TIGR01981 1034809009504 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1034809009505 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1034809009506 Walker A/P-loop; other site 1034809009507 ATP binding site [chemical binding]; other site 1034809009508 Q-loop/lid; other site 1034809009509 ABC transporter signature motif; other site 1034809009510 Walker B; other site 1034809009511 D-loop; other site 1034809009512 H-loop/switch region; other site 1034809009516 Predicted membrane protein [Function unknown]; Region: COG2035 1034809009518 CsbD-like; Region: CsbD; pfam05532 1034809009520 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1034809009521 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1034809009522 intersubunit interface [polypeptide binding]; other site 1034809009525 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1034809009526 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1034809009529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809009530 dimer interface [polypeptide binding]; other site 1034809009531 conserved gate region; other site 1034809009532 ABC-ATPase subunit interface; other site 1034809009535 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1034809009536 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1034809009537 Walker A/P-loop; other site 1034809009538 ATP binding site [chemical binding]; other site 1034809009539 Q-loop/lid; other site 1034809009540 ABC transporter signature motif; other site 1034809009541 Walker B; other site 1034809009542 D-loop; other site 1034809009543 H-loop/switch region; other site 1034809009544 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1034809009549 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034809009550 catalytic residues [active] 1034809009551 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1034809009552 putative active site [active] 1034809009553 putative metal binding site [ion binding]; other site 1034809009555 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1034809009556 lipoyl attachment site [posttranslational modification]; other site 1034809009558 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1034809009559 ArsC family; Region: ArsC; pfam03960 1034809009560 putative ArsC-like catalytic residues; other site 1034809009561 putative TRX-like catalytic residues [active] 1034809009563 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1034809009564 catalytic residues [active] 1034809009566 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1034809009567 putative FMN binding site [chemical binding]; other site 1034809009569 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1034809009570 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1034809009571 active site 1034809009572 catalytic residue [active] 1034809009573 dimer interface [polypeptide binding]; other site 1034809009576 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1034809009578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1034809009579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809009580 Coenzyme A binding pocket [chemical binding]; other site 1034809009582 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1034809009583 catalytic core [active] 1034809009586 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 1034809009588 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1034809009589 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1034809009591 DoxX; Region: DoxX; pfam07681 1034809009593 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1034809009594 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1034809009595 active site 1034809009596 metal binding site [ion binding]; metal-binding site 1034809009598 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1034809009599 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1034809009602 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1034809009603 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1034809009604 active site 1034809009605 metal binding site [ion binding]; metal-binding site 1034809009607 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1034809009609 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1034809009610 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1034809009612 H+ Antiporter protein; Region: 2A0121; TIGR00900 1034809009613 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1034809009614 active site residue [active] 1034809009615 MarR family; Region: MarR_2; cl17246 1034809009616 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034809009619 predicted helix-turn-helix motif with score1040.000,SD 2.73 at aa 75-96 1034809009620 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1034809009622 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1034809009623 SmpB-tmRNA interface; other site 1034809009626 ribonuclease R; Region: RNase_R; TIGR02063 1034809009627 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1034809009628 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1034809009629 RNB domain; Region: RNB; pfam00773 1034809009630 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1034809009631 RNA binding site [nucleotide binding]; other site 1034809009637 Esterase/lipase [General function prediction only]; Region: COG1647 1034809009638 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1034809009640 enolase; Provisional; Region: eno; PRK00077 1034809009641 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1034809009642 dimer interface [polypeptide binding]; other site 1034809009643 metal binding site [ion binding]; metal-binding site 1034809009644 substrate binding pocket [chemical binding]; other site 1034809009648 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1034809009649 phosphoglyceromutase; Provisional; Region: PRK05434 1034809009653 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1034809009654 triosephosphate isomerase; Provisional; Region: PRK14565 1034809009655 substrate binding site [chemical binding]; other site 1034809009656 dimer interface [polypeptide binding]; other site 1034809009657 catalytic triad [active] 1034809009660 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1034809009661 Phosphoglycerate kinase; Region: PGK; pfam00162 1034809009662 substrate binding site [chemical binding]; other site 1034809009663 hinge regions; other site 1034809009664 ADP binding site [chemical binding]; other site 1034809009665 catalytic site [active] 1034809009667 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1034809009668 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1034809009669 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1034809009674 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1034809009675 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1034809009677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809009678 TIGR01777 family protein; Region: yfcH 1034809009679 NAD(P) binding site [chemical binding]; other site 1034809009680 active site 1034809009683 Clp protease; Region: CLP_protease; pfam00574 1034809009684 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1034809009685 oligomer interface [polypeptide binding]; other site 1034809009686 active site residues [active] 1034809009690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1034809009691 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1034809009694 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1034809009695 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1034809009696 phosphate binding site [ion binding]; other site 1034809009697 putative substrate binding pocket [chemical binding]; other site 1034809009698 dimer interface [polypeptide binding]; other site 1034809009700 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1034809009704 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1034809009705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1034809009706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809009709 TPR repeat; Region: TPR_11; pfam13414 1034809009710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1034809009711 binding surface 1034809009712 TPR motif; other site 1034809009713 predicted helix-turn-helix motif with score999.000,SD 2.59 at aa 453-474 1034809009714 putative acyl transferase; Provisional; Region: PRK10191 1034809009715 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1034809009716 trimer interface [polypeptide binding]; other site 1034809009717 active site 1034809009718 substrate binding site [chemical binding]; other site 1034809009719 CoA binding site [chemical binding]; other site 1034809009724 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1034809009728 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1034809009729 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1034809009730 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1034809009731 Hpr binding site; other site 1034809009732 active site 1034809009733 homohexamer subunit interaction site [polypeptide binding]; other site 1034809009737 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1034809009738 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1034809009739 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1034809009740 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1034809009746 excinuclease ABC subunit B; Provisional; Region: PRK05298 1034809009747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034809009748 ATP binding site [chemical binding]; other site 1034809009749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034809009750 nucleotide binding region [chemical binding]; other site 1034809009751 ATP-binding site [chemical binding]; other site 1034809009752 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1034809009753 UvrB/uvrC motif; Region: UVR; pfam02151 1034809009755 predicted helix-turn-helix motif with score1219.000,SD 3.34 at aa 574-595 1034809009759 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1034809009761 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034809009762 Zn2+ binding site [ion binding]; other site 1034809009763 Mg2+ binding site [ion binding]; other site 1034809009764 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1034809009765 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034809009766 Surface antigen [General function prediction only]; Region: COG3942 1034809009767 CHAP domain; Region: CHAP; pfam05257 1034809009770 peptide chain release factor 2; Provisional; Region: PRK06746 1034809009771 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1034809009772 RF-1 domain; Region: RF-1; pfam00472 1034809009775 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1034809009776 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1034809009777 SEC-C motif; Region: SEC-C; pfam02810 1034809009784 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1034809009785 amidase catalytic site [active] 1034809009786 Zn binding residues [ion binding]; other site 1034809009787 substrate binding site [chemical binding]; other site 1034809009789 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1034809009790 30S subunit binding site; other site 1034809009792 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1034809009793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809009794 active site 1034809009795 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1034809009796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034809009797 ATP binding site [chemical binding]; other site 1034809009798 putative Mg++ binding site [ion binding]; other site 1034809009799 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034809009800 nucleotide binding region [chemical binding]; other site 1034809009801 ATP-binding site [chemical binding]; other site 1034809009805 EDD domain protein, DegV family; Region: DegV; TIGR00762 1034809009806 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1034809009809 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1034809009810 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1034809009811 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1034809009815 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1034809009816 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1034809009817 Mg++ binding site [ion binding]; other site 1034809009818 putative catalytic motif [active] 1034809009819 substrate binding site [chemical binding]; other site 1034809009821 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1034809009822 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1034809009823 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1034809009824 metal binding site [ion binding]; metal-binding site 1034809009825 active site 1034809009826 I-site; other site 1034809009830 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1034809009831 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1034809009834 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1034809009835 peptidase T; Region: peptidase-T; TIGR01882 1034809009836 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1034809009837 metal binding site [ion binding]; metal-binding site 1034809009838 dimer interface [polypeptide binding]; other site 1034809009844 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1034809009846 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1034809009848 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1034809009850 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1034809009851 FAD binding domain; Region: FAD_binding_4; pfam01565 1034809009852 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1034809009855 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1034809009856 CHY zinc finger; Region: zf-CHY; pfam05495 1034809009858 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1034809009859 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1034809009860 putative ligand binding residues [chemical binding]; other site 1034809009865 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1034809009866 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1034809009867 Walker A/P-loop; other site 1034809009868 ATP binding site [chemical binding]; other site 1034809009869 Q-loop/lid; other site 1034809009870 ABC transporter signature motif; other site 1034809009871 Walker B; other site 1034809009872 D-loop; other site 1034809009873 H-loop/switch region; other site 1034809009876 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1034809009877 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809009878 ABC-ATPase subunit interface; other site 1034809009879 dimer interface [polypeptide binding]; other site 1034809009880 putative PBP binding regions; other site 1034809009882 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809009883 ABC-ATPase subunit interface; other site 1034809009884 dimer interface [polypeptide binding]; other site 1034809009885 putative PBP binding regions; other site 1034809009888 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1034809009889 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1034809009890 intersubunit interface [polypeptide binding]; other site 1034809009894 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1034809009895 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1034809009896 Walker A/P-loop; other site 1034809009897 ATP binding site [chemical binding]; other site 1034809009898 Q-loop/lid; other site 1034809009899 ABC transporter signature motif; other site 1034809009900 Walker B; other site 1034809009901 D-loop; other site 1034809009902 H-loop/switch region; other site 1034809009905 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809009906 ABC-ATPase subunit interface; other site 1034809009907 dimer interface [polypeptide binding]; other site 1034809009908 putative PBP binding regions; other site 1034809009910 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1034809009911 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809009912 ABC-ATPase subunit interface; other site 1034809009913 dimer interface [polypeptide binding]; other site 1034809009914 putative PBP binding regions; other site 1034809009917 predicted helix-turn-helix motif with score1010.000,SD 2.63 at aa 26-47 1034809009918 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1034809009919 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1034809009920 dimer interface [polypeptide binding]; other site 1034809009921 putative radical transfer pathway; other site 1034809009922 diiron center [ion binding]; other site 1034809009923 tyrosyl radical; other site 1034809009925 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1034809009926 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1034809009927 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1034809009928 active site 1034809009929 dimer interface [polypeptide binding]; other site 1034809009930 catalytic residues [active] 1034809009931 effector binding site; other site 1034809009932 R2 peptide binding site; other site 1034809009938 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1034809009940 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1034809009943 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1034809009945 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1034809009946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809009947 putative substrate translocation pore; other site 1034809009948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809009951 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1034809009952 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1034809009954 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1034809009956 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1034809009957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034809009958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809009959 homodimer interface [polypeptide binding]; other site 1034809009960 catalytic residue [active] 1034809009963 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1034809009964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809009965 putative substrate translocation pore; other site 1034809009966 POT family; Region: PTR2; cl17359 1034809009970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809009971 dimer interface [polypeptide binding]; other site 1034809009972 conserved gate region; other site 1034809009973 ABC-ATPase subunit interface; other site 1034809009974 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1034809009975 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1034809009979 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1034809009980 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1034809009981 Walker A/P-loop; other site 1034809009982 ATP binding site [chemical binding]; other site 1034809009983 Q-loop/lid; other site 1034809009984 ABC transporter signature motif; other site 1034809009985 Walker B; other site 1034809009986 D-loop; other site 1034809009987 H-loop/switch region; other site 1034809009992 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1034809009993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034809009994 ATP binding site [chemical binding]; other site 1034809009995 putative Mg++ binding site [ion binding]; other site 1034809009996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034809009997 nucleotide binding region [chemical binding]; other site 1034809009998 ATP-binding site [chemical binding]; other site 1034809009999 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1034809010000 HRDC domain; Region: HRDC; pfam00570 1034809010005 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1034809010006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809010007 Walker A/P-loop; other site 1034809010008 ATP binding site [chemical binding]; other site 1034809010009 Q-loop/lid; other site 1034809010010 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809010011 ABC transporter; Region: ABC_tran_2; pfam12848 1034809010012 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1034809010018 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1034809010020 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1034809010021 Predicted integral membrane protein [Function unknown]; Region: COG5650 1034809010022 Sulfatase; Region: Sulfatase; pfam00884 1034809010024 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1034809010026 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1034809010027 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1034809010029 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1034809010030 substrate-cofactor binding pocket; other site 1034809010031 homodimer interface [polypeptide binding]; other site 1034809010032 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1034809010033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809010034 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1034809010035 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1034809010037 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1034809010038 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1034809010039 glutamine binding [chemical binding]; other site 1034809010040 catalytic triad [active] 1034809010043 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1034809010044 Ligand Binding Site [chemical binding]; other site 1034809010046 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1034809010047 active site 1034809010049 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1034809010050 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1034809010052 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1034809010053 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1034809010054 Ligand binding site; other site 1034809010055 Putative Catalytic site; other site 1034809010056 DXD motif; other site 1034809010058 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034809010059 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1034809010060 active site 1034809010061 catalytic tetrad [active] 1034809010067 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1034809010068 Domain of unknown function DUF21; Region: DUF21; pfam01595 1034809010069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1034809010070 Transporter associated domain; Region: CorC_HlyC; smart01091 1034809010074 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1034809010075 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1034809010076 active site 1034809010077 phosphorylation site [posttranslational modification] 1034809010078 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1034809010079 active site 1034809010080 P-loop; other site 1034809010081 phosphorylation site [posttranslational modification] 1034809010082 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1034809010087 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1034809010088 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1034809010089 putative substrate binding site [chemical binding]; other site 1034809010090 putative ATP binding site [chemical binding]; other site 1034809010093 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1034809010094 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1034809010095 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1034809010098 predicted helix-turn-helix motif with score1454.000,SD 4.14 at aa 20-41 1034809010100 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1034809010101 putative deacylase active site [active] 1034809010103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809010104 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1034809010105 putative substrate translocation pore; other site 1034809010107 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1034809010109 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1034809010110 DNA photolyase; Region: DNA_photolyase; pfam00875 1034809010112 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1034809010113 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1034809010114 transmembrane helices; other site 1034809010116 malate dehydrogenase; Reviewed; Region: PRK06223 1034809010117 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1034809010118 NAD(P) binding site [chemical binding]; other site 1034809010119 dimer interface [polypeptide binding]; other site 1034809010120 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034809010121 substrate binding site [chemical binding]; other site 1034809010125 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1034809010126 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1034809010127 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1034809010132 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034809010133 MarR family; Region: MarR; pfam01047 1034809010135 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1034809010137 hypothetical protein; Validated; Region: PRK00124 1034809010139 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1034809010141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1034809010142 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1034809010143 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1034809010146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809010147 sugar efflux transporter; Region: 2A0120; TIGR00899 1034809010148 putative substrate translocation pore; other site 1034809010150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034809010151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1034809010152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1034809010153 dimerization interface [polypeptide binding]; other site 1034809010157 predicted helix-turn-helix motif with score1725.000,SD 5.06 at aa 16-37 1034809010158 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1034809010160 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1034809010162 hypothetical protein; Provisional; Region: PRK12378 1034809010164 MarR family; Region: MarR_2; cl17246 1034809010165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1034809010166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1034809010169 predicted helix-turn-helix motif with score1127.000,SD 3.03 at aa 167-188 1034809010170 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1034809010171 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 1034809010173 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034809010174 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034809010175 Surface antigen [General function prediction only]; Region: COG3942 1034809010176 CHAP domain; Region: CHAP; pfam05257 1034809010180 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1034809010182 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1034809010184 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1034809010185 FtsX-like permease family; Region: FtsX; pfam02687 1034809010188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034809010189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1034809010190 Walker A/P-loop; other site 1034809010191 ATP binding site [chemical binding]; other site 1034809010192 Q-loop/lid; other site 1034809010193 ABC transporter signature motif; other site 1034809010194 Walker B; other site 1034809010195 D-loop; other site 1034809010196 H-loop/switch region; other site 1034809010199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034809010200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1034809010201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809010202 ATP binding site [chemical binding]; other site 1034809010203 Mg2+ binding site [ion binding]; other site 1034809010204 G-X-G motif; other site 1034809010206 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809010207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809010208 active site 1034809010209 phosphorylation site [posttranslational modification] 1034809010210 intermolecular recognition site; other site 1034809010211 dimerization interface [polypeptide binding]; other site 1034809010212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809010213 DNA binding site [nucleotide binding] 1034809010216 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1034809010217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809010218 NAD(P) binding site [chemical binding]; other site 1034809010219 active site 1034809010220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1034809010221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809010222 Coenzyme A binding pocket [chemical binding]; other site 1034809010224 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1034809010225 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1034809010226 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1034809010228 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1034809010229 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1034809010230 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 1034809010231 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1034809010233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1034809010234 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1034809010235 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809010236 ABC-ATPase subunit interface; other site 1034809010237 dimer interface [polypeptide binding]; other site 1034809010238 putative PBP binding regions; other site 1034809010241 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1034809010242 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809010243 ABC-ATPase subunit interface; other site 1034809010244 dimer interface [polypeptide binding]; other site 1034809010245 putative PBP binding regions; other site 1034809010247 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1034809010248 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1034809010249 Walker A/P-loop; other site 1034809010250 ATP binding site [chemical binding]; other site 1034809010251 Q-loop/lid; other site 1034809010252 ABC transporter signature motif; other site 1034809010253 Walker B; other site 1034809010254 D-loop; other site 1034809010255 H-loop/switch region; other site 1034809010258 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1034809010259 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1034809010260 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1034809010264 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1034809010265 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1034809010266 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1034809010270 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1034809010271 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034809010272 active site 1034809010273 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1034809010274 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1034809010277 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1034809010278 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1034809010279 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1034809010282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034809010283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1034809010284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809010285 Walker A/P-loop; other site 1034809010286 ATP binding site [chemical binding]; other site 1034809010287 Q-loop/lid; other site 1034809010288 ABC transporter signature motif; other site 1034809010289 Walker B; other site 1034809010290 D-loop; other site 1034809010291 H-loop/switch region; other site 1034809010296 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1034809010297 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1034809010298 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1034809010301 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1034809010302 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1034809010303 active site 1034809010304 nucleotide binding site [chemical binding]; other site 1034809010305 HIGH motif; other site 1034809010306 KMSKS motif; other site 1034809010308 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1034809010309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034809010310 active site 1034809010312 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1034809010314 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1034809010315 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1034809010318 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1034809010319 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1034809010320 Walker A/P-loop; other site 1034809010321 ATP binding site [chemical binding]; other site 1034809010322 Q-loop/lid; other site 1034809010323 ABC transporter signature motif; other site 1034809010324 Walker B; other site 1034809010325 D-loop; other site 1034809010326 H-loop/switch region; other site 1034809010330 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1034809010331 formate dehydrogenase; Provisional; Region: PRK07574 1034809010332 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1034809010333 NAD binding site [chemical binding]; other site 1034809010339 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1034809010340 putative myristoylated protein; Provisional; Region: PHA03056 1034809010341 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1034809010343 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1034809010345 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1034809010346 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1034809010347 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1034809010348 FeoA domain; Region: FeoA; pfam04023 1034809010352 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1034809010353 ABC transporter; Region: ABC_tran; pfam00005 1034809010357 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1034809010358 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809010359 ABC-ATPase subunit interface; other site 1034809010360 dimer interface [polypeptide binding]; other site 1034809010361 putative PBP binding regions; other site 1034809010364 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1034809010365 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1034809010366 metal binding site [ion binding]; metal-binding site 1034809010370 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1034809010371 predicted helix-turn-helix motif with score1228.000,SD 3.37 at aa 505-526 1034809010373 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1034809010375 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1034809010377 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1034809010379 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1034809010380 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1034809010383 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1034809010385 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1034809010387 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1034809010388 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1034809010389 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1034809010390 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1034809010393 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1034809010394 active site 1034809010395 DNA binding site [nucleotide binding] 1034809010396 Int/Topo IB signature motif; other site 1034809010398 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1034809010399 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1034809010400 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1034809010403 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1034809010404 HlyD family secretion protein; Region: HlyD_3; pfam13437 1034809010405 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1034809010406 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1034809010407 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1034809010408 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1034809010409 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1034809010412 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1034809010413 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1034809010415 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1034809010416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809010417 motif II; other site 1034809010420 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1034809010421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1034809010422 ABC-ATPase subunit interface; other site 1034809010423 dimer interface [polypeptide binding]; other site 1034809010424 putative PBP binding regions; other site 1034809010426 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1034809010427 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1034809010428 putative binding site residues; other site 1034809010431 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1034809010433 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1034809010434 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1034809010435 DNA binding residues [nucleotide binding] 1034809010436 dimer interface [polypeptide binding]; other site 1034809010437 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1034809010440 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1034809010441 minor groove reading motif; other site 1034809010442 helix-hairpin-helix signature motif; other site 1034809010443 active site 1034809010445 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1034809010446 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1034809010447 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1034809010448 active site 1034809010449 HIGH motif; other site 1034809010450 KMSK motif region; other site 1034809010451 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1034809010452 tRNA binding surface [nucleotide binding]; other site 1034809010453 anticodon binding site; other site 1034809010458 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1034809010460 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1034809010462 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1034809010463 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1034809010464 NAD binding site [chemical binding]; other site 1034809010465 substrate binding site [chemical binding]; other site 1034809010466 catalytic Zn binding site [ion binding]; other site 1034809010467 tetramer interface [polypeptide binding]; other site 1034809010468 structural Zn binding site [ion binding]; other site 1034809010473 YwhD family; Region: YwhD; pfam08741 1034809010476 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1034809010477 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1034809010478 Zn2+ binding site [ion binding]; other site 1034809010479 Mg2+ binding site [ion binding]; other site 1034809010481 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1034809010482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809010483 Coenzyme A binding pocket [chemical binding]; other site 1034809010485 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1034809010486 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1034809010488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1034809010489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1034809010490 active site 1034809010491 catalytic tetrad [active] 1034809010494 Predicted transcriptional regulator [Transcription]; Region: COG1959 1034809010495 Transcriptional regulator; Region: Rrf2; pfam02082 1034809010497 predicted helix-turn-helix motif with score1380.000,SD 3.89 at aa 24-45 1034809010498 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1034809010499 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1034809010500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809010501 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1034809010507 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1034809010508 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1034809010512 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1034809010513 diphosphomevalonate decarboxylase; Region: PLN02407 1034809010517 mevalonate kinase; Region: mevalon_kin; TIGR00549 1034809010518 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1034809010519 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1034809010521 predicted helix-turn-helix motif with score1009.000,SD 2.62 at aa 223-244 1034809010524 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1034809010526 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1034809010528 putative heme peroxidase; Provisional; Region: PRK12276 1034809010531 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1034809010533 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1034809010534 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1034809010536 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1034809010538 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1034809010540 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1034809010542 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1034809010543 ligand binding site [chemical binding]; other site 1034809010544 active site 1034809010545 UGI interface [polypeptide binding]; other site 1034809010546 catalytic site [active] 1034809010549 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1034809010550 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1034809010551 active site 1034809010553 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1034809010554 dimer interface [polypeptide binding]; other site 1034809010555 substrate binding site [chemical binding]; other site 1034809010556 ATP binding site [chemical binding]; other site 1034809010559 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1034809010560 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1034809010562 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1034809010563 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1034809010564 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1034809010568 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1034809010569 proline/glycine betaine transporter; Provisional; Region: PRK10642 1034809010570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809010571 putative substrate translocation pore; other site 1034809010574 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1034809010575 tetramer interface [polypeptide binding]; other site 1034809010576 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1034809010577 active site 1034809010579 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1034809010580 active site 1034809010581 dimer interface [polypeptide binding]; other site 1034809010582 magnesium binding site [ion binding]; other site 1034809010584 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1034809010586 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1034809010588 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1034809010590 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1034809010591 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1034809010592 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1034809010593 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1034809010596 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1034809010597 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1034809010598 active site 1034809010600 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1034809010601 Rib/alpha-like repeat; Region: Rib; cl07159 1034809010602 Rib/alpha-like repeat; Region: Rib; cl07159 1034809010603 Rib/alpha-like repeat; Region: Rib; cl07159 1034809010604 Rib/alpha-like repeat; Region: Rib; cl07159 1034809010605 Rib/alpha-like repeat; Region: Rib; cl07159 1034809010606 Rib/alpha-like repeat; Region: Rib; cl07159 1034809010613 Predicted flavoprotein [General function prediction only]; Region: COG0431 1034809010614 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1034809010616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809010617 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1034809010618 active site 1034809010619 motif I; other site 1034809010620 motif II; other site 1034809010621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809010625 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1034809010626 nucleoside/Zn binding site; other site 1034809010627 dimer interface [polypeptide binding]; other site 1034809010628 catalytic motif [active] 1034809010631 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1034809010632 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1034809010633 Substrate-binding site [chemical binding]; other site 1034809010634 Substrate specificity [chemical binding]; other site 1034809010637 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1034809010638 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1034809010639 Substrate-binding site [chemical binding]; other site 1034809010640 Substrate specificity [chemical binding]; other site 1034809010643 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1034809010644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1034809010645 motif II; other site 1034809010647 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1034809010648 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1034809010649 hexamer interface [polypeptide binding]; other site 1034809010650 ligand binding site [chemical binding]; other site 1034809010651 putative active site [active] 1034809010652 NAD(P) binding site [chemical binding]; other site 1034809010655 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1034809010656 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1034809010657 tetramer interface [polypeptide binding]; other site 1034809010658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809010659 catalytic residue [active] 1034809010661 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1034809010664 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1034809010665 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1034809010666 homodimer interface [polypeptide binding]; other site 1034809010667 substrate-cofactor binding pocket; other site 1034809010668 catalytic residue [active] 1034809010671 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1034809010672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809010673 NAD(P) binding site [chemical binding]; other site 1034809010674 active site 1034809010676 CDS contains a frameshift after residue 107 1034809010680 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1034809010681 nudix motif; other site 1034809010684 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1034809010685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809010686 Coenzyme A binding pocket [chemical binding]; other site 1034809010688 ornithine cyclodeaminase; Validated; Region: PRK08618 1034809010689 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1034809010691 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1034809010692 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1034809010693 substrate-cofactor binding pocket; other site 1034809010694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809010695 catalytic residue [active] 1034809010698 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1034809010699 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1034809010700 metal binding site [ion binding]; metal-binding site 1034809010701 dimer interface [polypeptide binding]; other site 1034809010704 elongation factor Tu; Reviewed; Region: PRK00049 1034809010705 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1034809010706 G1 box; other site 1034809010707 GEF interaction site [polypeptide binding]; other site 1034809010708 GTP/Mg2+ binding site [chemical binding]; other site 1034809010709 Switch I region; other site 1034809010710 G2 box; other site 1034809010711 G3 box; other site 1034809010712 Switch II region; other site 1034809010713 G4 box; other site 1034809010714 G5 box; other site 1034809010715 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1034809010716 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1034809010717 Antibiotic Binding Site [chemical binding]; other site 1034809010723 elongation factor G; Reviewed; Region: PRK00007 1034809010724 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1034809010725 G1 box; other site 1034809010726 putative GEF interaction site [polypeptide binding]; other site 1034809010727 GTP/Mg2+ binding site [chemical binding]; other site 1034809010728 Switch I region; other site 1034809010729 G2 box; other site 1034809010730 G3 box; other site 1034809010731 Switch II region; other site 1034809010732 G4 box; other site 1034809010733 G5 box; other site 1034809010734 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1034809010735 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1034809010736 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1034809010743 30S ribosomal protein S7; Validated; Region: PRK05302 1034809010746 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1034809010747 S17 interaction site [polypeptide binding]; other site 1034809010748 S8 interaction site; other site 1034809010749 16S rRNA interaction site [nucleotide binding]; other site 1034809010750 streptomycin interaction site [chemical binding]; other site 1034809010751 23S rRNA interaction site [nucleotide binding]; other site 1034809010752 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1034809010755 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1034809010757 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1034809010758 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1034809010759 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1034809010760 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1034809010761 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1034809010762 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1034809010763 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1034809010764 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1034809010765 G-loop; other site 1034809010766 DNA binding site [nucleotide binding] 1034809010773 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1034809010774 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1034809010775 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1034809010776 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1034809010777 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1034809010778 RPB12 interaction site [polypeptide binding]; other site 1034809010779 RPB10 interaction site [polypeptide binding]; other site 1034809010780 RPB1 interaction site [polypeptide binding]; other site 1034809010781 RPB11 interaction site [polypeptide binding]; other site 1034809010782 RPB3 interaction site [polypeptide binding]; other site 1034809010783 RPB12 interaction site [polypeptide binding]; other site 1034809010793 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1034809010794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809010795 S-adenosylmethionine binding site [chemical binding]; other site 1034809010797 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1034809010798 peripheral dimer interface [polypeptide binding]; other site 1034809010799 core dimer interface [polypeptide binding]; other site 1034809010800 L10 interface [polypeptide binding]; other site 1034809010801 L11 interface [polypeptide binding]; other site 1034809010802 putative EF-Tu interaction site [polypeptide binding]; other site 1034809010803 putative EF-G interaction site [polypeptide binding]; other site 1034809010805 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1034809010806 23S rRNA interface [nucleotide binding]; other site 1034809010807 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1034809010810 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1034809010811 mRNA/rRNA interface [nucleotide binding]; other site 1034809010814 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1034809010815 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1034809010816 23S rRNA interface [nucleotide binding]; other site 1034809010817 L7/L12 interface [polypeptide binding]; other site 1034809010818 putative thiostrepton binding site; other site 1034809010819 L25 interface [polypeptide binding]; other site 1034809010823 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1034809010824 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1034809010825 putative homodimer interface [polypeptide binding]; other site 1034809010826 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1034809010827 heterodimer interface [polypeptide binding]; other site 1034809010828 homodimer interface [polypeptide binding]; other site 1034809010832 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1034809010835 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1034809010836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1034809010838 YacP-like NYN domain; Region: NYN_YacP; cl01491 1034809010840 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1034809010841 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1034809010842 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1034809010845 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1034809010846 active site 1034809010847 metal binding site [ion binding]; metal-binding site 1034809010848 dimerization interface [polypeptide binding]; other site 1034809010850 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1034809010851 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1034809010852 active site 1034809010853 HIGH motif; other site 1034809010854 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1034809010855 KMSKS motif; other site 1034809010856 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1034809010857 tRNA binding surface [nucleotide binding]; other site 1034809010858 anticodon binding site; other site 1034809010862 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1034809010863 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1034809010864 trimer interface [polypeptide binding]; other site 1034809010865 active site 1034809010866 substrate binding site [chemical binding]; other site 1034809010867 CoA binding site [chemical binding]; other site 1034809010873 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1034809010874 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1034809010875 active site 1034809010876 HIGH motif; other site 1034809010877 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1034809010878 active site 1034809010879 KMSKS motif; other site 1034809010882 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1034809010883 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1034809010884 putative active site [active] 1034809010887 DNA repair protein RadA; Provisional; Region: PRK11823 1034809010888 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1034809010889 Walker A motif/ATP binding site; other site 1034809010890 ATP binding site [chemical binding]; other site 1034809010891 Walker B motif; other site 1034809010892 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1034809010894 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1034809010895 Clp amino terminal domain; Region: Clp_N; pfam02861 1034809010896 Clp amino terminal domain; Region: Clp_N; pfam02861 1034809010897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809010898 Walker A motif; other site 1034809010899 ATP binding site [chemical binding]; other site 1034809010900 Walker B motif; other site 1034809010901 arginine finger; other site 1034809010902 UvrB/uvrC motif; Region: UVR; pfam02151 1034809010903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809010904 Walker A motif; other site 1034809010905 ATP binding site [chemical binding]; other site 1034809010906 Walker B motif; other site 1034809010907 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1034809010918 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1034809010919 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1034809010920 ADP binding site [chemical binding]; other site 1034809010921 phosphagen binding site; other site 1034809010922 substrate specificity loop; other site 1034809010925 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1034809010926 UvrB/uvrC motif; Region: UVR; pfam02151 1034809010928 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1034809010930 predicted helix-turn-helix motif with score1132.000,SD 3.04 at aa 26-47 1034809010931 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1034809010932 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1034809010933 Nucleoside recognition; Region: Gate; pfam07670 1034809010934 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1034809010937 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1034809010938 predicted active site [active] 1034809010939 catalytic triad [active] 1034809010942 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1034809010943 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1034809010944 active site 1034809010945 multimer interface [polypeptide binding]; other site 1034809010948 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1034809010949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034809010950 DNA-binding site [nucleotide binding]; DNA binding site 1034809010951 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1034809010952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809010953 homodimer interface [polypeptide binding]; other site 1034809010954 catalytic residue [active] 1034809010956 predicted helix-turn-helix motif with score1130.000,SD 3.04 at aa 31-52 1034809010957 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1034809010958 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1034809010959 dimer interface [polypeptide binding]; other site 1034809010960 putative anticodon binding site; other site 1034809010961 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1034809010962 motif 1; other site 1034809010963 active site 1034809010964 motif 2; other site 1034809010965 motif 3; other site 1034809010970 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1034809010971 catalytic center binding site [active] 1034809010972 ATP binding site [chemical binding]; other site 1034809010975 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1034809010976 homooctamer interface [polypeptide binding]; other site 1034809010977 active site 1034809010979 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1034809010980 dihydropteroate synthase; Region: DHPS; TIGR01496 1034809010981 substrate binding pocket [chemical binding]; other site 1034809010982 dimer interface [polypeptide binding]; other site 1034809010983 inhibitor binding site; inhibition site 1034809010986 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1034809010987 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1034809010988 dimer interface [polypeptide binding]; other site 1034809010989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809010990 catalytic residue [active] 1034809010993 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1034809010994 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1034809010995 dimerization interface [polypeptide binding]; other site 1034809010996 domain crossover interface; other site 1034809010997 redox-dependent activation switch; other site 1034809010999 FtsH Extracellular; Region: FtsH_ext; pfam06480 1034809011000 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1034809011001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809011002 Walker A motif; other site 1034809011003 ATP binding site [chemical binding]; other site 1034809011004 Walker B motif; other site 1034809011005 arginine finger; other site 1034809011006 Peptidase family M41; Region: Peptidase_M41; pfam01434 1034809011012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809011013 active site 1034809011015 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1034809011016 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1034809011017 Ligand Binding Site [chemical binding]; other site 1034809011018 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1034809011020 hypothetical protein; Provisional; Region: PRK08582 1034809011021 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1034809011022 RNA binding site [nucleotide binding]; other site 1034809011024 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1034809011025 Septum formation initiator; Region: DivIC; pfam04977 1034809011027 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1034809011028 RNA binding surface [nucleotide binding]; other site 1034809011030 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1034809011031 putative SAM binding site [chemical binding]; other site 1034809011032 putative homodimer interface [polypeptide binding]; other site 1034809011033 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1034809011034 homodimer interface [polypeptide binding]; other site 1034809011035 metal binding site [ion binding]; metal-binding site 1034809011039 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1034809011040 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1034809011043 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1034809011044 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1034809011045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1034809011046 ATP binding site [chemical binding]; other site 1034809011047 putative Mg++ binding site [ion binding]; other site 1034809011048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1034809011049 nucleotide binding region [chemical binding]; other site 1034809011050 ATP-binding site [chemical binding]; other site 1034809011051 TRCF domain; Region: TRCF; pfam03461 1034809011057 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1034809011058 putative active site [active] 1034809011059 catalytic residue [active] 1034809011063 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1034809011064 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1034809011065 5S rRNA interface [nucleotide binding]; other site 1034809011066 CTC domain interface [polypeptide binding]; other site 1034809011067 L16 interface [polypeptide binding]; other site 1034809011069 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1034809011070 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1034809011071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809011072 active site 1034809011076 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1034809011077 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1034809011078 Substrate binding site; other site 1034809011079 Mg++ binding site; other site 1034809011080 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1034809011081 active site 1034809011082 substrate binding site [chemical binding]; other site 1034809011083 CoA binding site [chemical binding]; other site 1034809011093 regulatory protein SpoVG; Reviewed; Region: PRK13259 1034809011095 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1034809011096 homotrimer interaction site [polypeptide binding]; other site 1034809011097 putative active site [active] 1034809011100 pur operon repressor; Provisional; Region: PRK09213 1034809011101 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1034809011102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809011103 active site 1034809011106 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1034809011107 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1034809011108 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1034809011111 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1034809011113 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1034809011114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809011115 S-adenosylmethionine binding site [chemical binding]; other site 1034809011118 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1034809011119 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1034809011120 putative active site [active] 1034809011121 putative metal binding site [ion binding]; other site 1034809011122 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1034809011123 predicted helix-turn-helix motif with score986.000,SD 2.55 at aa 138-159 1034809011125 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1034809011126 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1034809011127 active site 1034809011129 predicted helix-turn-helix motif with score980.000,SD 2.52 at aa 225-246 1034809011132 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1034809011133 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1034809011134 active site 1034809011135 HIGH motif; other site 1034809011136 KMSKS motif; other site 1034809011137 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1034809011138 tRNA binding surface [nucleotide binding]; other site 1034809011139 anticodon binding site; other site 1034809011140 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1034809011141 dimer interface [polypeptide binding]; other site 1034809011142 putative tRNA-binding site [nucleotide binding]; other site 1034809011149 Predicted methyltransferases [General function prediction only]; Region: COG0313 1034809011150 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1034809011151 putative SAM binding site [chemical binding]; other site 1034809011152 putative homodimer interface [polypeptide binding]; other site 1034809011155 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1034809011156 GIY-YIG motif/motif A; other site 1034809011157 putative active site [active] 1034809011158 putative metal binding site [ion binding]; other site 1034809011160 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1034809011161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809011162 S-adenosylmethionine binding site [chemical binding]; other site 1034809011164 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1034809011166 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1034809011168 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1034809011169 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1034809011170 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1034809011172 thymidylate kinase; Validated; Region: tmk; PRK00698 1034809011173 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1034809011174 TMP-binding site; other site 1034809011175 ATP-binding site [chemical binding]; other site 1034809011179 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1034809011180 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034809011181 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034809011182 catalytic residue [active] 1034809011183 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1034809011186 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1034809011187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809011188 Coenzyme A binding pocket [chemical binding]; other site 1034809011190 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1034809011191 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1034809011192 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 1034809011193 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 1034809011194 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 1034809011195 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 1034809011196 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 1034809011197 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 1034809011200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1034809011201 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1034809011202 predicted helix-turn-helix motif with score1073.000,SD 2.84 at aa 248-269 1034809011204 predicted helix-turn-helix motif with score1570.000,SD 4.53 at aa 125-146 1034809011205 recombination protein RecR; Reviewed; Region: recR; PRK00076 1034809011206 RecR protein; Region: RecR; pfam02132 1034809011207 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1034809011208 putative active site [active] 1034809011209 putative metal-binding site [ion binding]; other site 1034809011210 tetramer interface [polypeptide binding]; other site 1034809011214 hypothetical protein; Validated; Region: PRK00153 1034809011216 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1034809011217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1034809011218 Walker A motif; other site 1034809011219 ATP binding site [chemical binding]; other site 1034809011220 Walker B motif; other site 1034809011221 arginine finger; other site 1034809011225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1034809011226 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1034809011227 Coenzyme A binding pocket [chemical binding]; other site 1034809011229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1034809011230 DNA-binding site [nucleotide binding]; DNA binding site 1034809011231 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1034809011232 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1034809011236 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1034809011237 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1034809011238 Ca binding site [ion binding]; other site 1034809011239 active site 1034809011240 catalytic site [active] 1034809011241 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1034809011243 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1034809011244 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1034809011245 active site turn [active] 1034809011246 phosphorylation site [posttranslational modification] 1034809011247 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1034809011251 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1034809011252 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1034809011254 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1034809011255 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1034809011256 active site 1034809011257 dimer interface [polypeptide binding]; other site 1034809011258 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1034809011259 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1034809011260 active site 1034809011261 FMN binding site [chemical binding]; other site 1034809011262 substrate binding site [chemical binding]; other site 1034809011263 3Fe-4S cluster binding site [ion binding]; other site 1034809011264 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1034809011265 domain interface; other site 1034809011269 predicted helix-turn-helix motif with score1096.000,SD 2.92 at aa 720-741 1034809011271 predicted helix-turn-helix motif with score973.000,SD 2.50 at aa 452-473 1034809011273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1034809011274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1034809011275 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1034809011276 dimerization interface [polypeptide binding]; other site 1034809011278 predicted helix-turn-helix motif with score1623.000,SD 4.71 at aa 16-37 1034809011281 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1034809011283 YibE/F-like protein; Region: YibE_F; cl02259 1034809011286 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1034809011287 nudix motif; other site 1034809011290 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034809011291 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1034809011292 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034809011293 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1034809011294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1034809011295 CHAP domain; Region: CHAP; pfam05257 1034809011296 Surface antigen [General function prediction only]; Region: COG3942 1034809011301 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1034809011302 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1034809011306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1034809011307 dimer interface [polypeptide binding]; other site 1034809011308 conserved gate region; other site 1034809011309 ABC-ATPase subunit interface; other site 1034809011312 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1034809011313 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1034809011314 Walker A/P-loop; other site 1034809011315 ATP binding site [chemical binding]; other site 1034809011316 Q-loop/lid; other site 1034809011317 ABC transporter signature motif; other site 1034809011318 Walker B; other site 1034809011319 D-loop; other site 1034809011320 H-loop/switch region; other site 1034809011321 NIL domain; Region: NIL; pfam09383 1034809011326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1034809011327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809011328 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1034809011329 Walker A/P-loop; other site 1034809011330 ATP binding site [chemical binding]; other site 1034809011331 Q-loop/lid; other site 1034809011332 ABC transporter signature motif; other site 1034809011333 Walker B; other site 1034809011334 D-loop; other site 1034809011335 H-loop/switch region; other site 1034809011340 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1034809011341 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1034809011342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809011343 Walker A/P-loop; other site 1034809011344 ATP binding site [chemical binding]; other site 1034809011345 Q-loop/lid; other site 1034809011346 ABC transporter signature motif; other site 1034809011347 Walker B; other site 1034809011348 D-loop; other site 1034809011349 H-loop/switch region; other site 1034809011354 cystathionine beta-lyase; Provisional; Region: PRK07671 1034809011355 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1034809011356 homodimer interface [polypeptide binding]; other site 1034809011357 substrate-cofactor binding pocket; other site 1034809011358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809011359 catalytic residue [active] 1034809011362 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1034809011363 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1034809011364 dimer interface [polypeptide binding]; other site 1034809011365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809011366 catalytic residue [active] 1034809011369 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1034809011370 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1034809011371 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1034809011372 Na2 binding site [ion binding]; other site 1034809011373 putative substrate binding site 1 [chemical binding]; other site 1034809011374 Na binding site 1 [ion binding]; other site 1034809011375 putative substrate binding site 2 [chemical binding]; other site 1034809011377 Esterase/lipase [General function prediction only]; Region: COG1647 1034809011378 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1034809011381 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1034809011382 active site 1034809011385 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1034809011387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1034809011388 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1034809011391 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1034809011392 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1034809011394 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1034809011395 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1034809011396 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1034809011400 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1034809011403 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1034809011404 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1034809011405 putative DNA binding site [nucleotide binding]; other site 1034809011406 putative Zn2+ binding site [ion binding]; other site 1034809011408 predicted helix-turn-helix motif with score1379.000,SD 3.88 at aa 51-72 1034809011409 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1034809011410 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1034809011411 active site 1034809011412 nucleophile elbow; other site 1034809011414 GMP synthase; Reviewed; Region: guaA; PRK00074 1034809011415 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1034809011416 AMP/PPi binding site [chemical binding]; other site 1034809011417 candidate oxyanion hole; other site 1034809011418 catalytic triad [active] 1034809011419 potential glutamine specificity residues [chemical binding]; other site 1034809011420 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1034809011421 ATP Binding subdomain [chemical binding]; other site 1034809011422 Ligand Binding sites [chemical binding]; other site 1034809011423 Dimerization subdomain; other site 1034809011427 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1034809011428 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1034809011429 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1034809011430 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1034809011431 active site 1034809011435 xanthine permease; Region: pbuX; TIGR03173 1034809011441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1034809011442 active site 1034809011444 Heat induced stress protein YflT; Region: YflT; pfam11181 1034809011445 predicted helix-turn-helix motif with score1266.000,SD 3.50 at aa 1-22 1034809011446 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1034809011447 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1034809011450 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1034809011451 dimer interface [polypeptide binding]; other site 1034809011452 FMN binding site [chemical binding]; other site 1034809011453 NADPH bind site [chemical binding]; other site 1034809011455 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1034809011456 peroxiredoxin; Region: AhpC; TIGR03137 1034809011457 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1034809011458 dimer interface [polypeptide binding]; other site 1034809011459 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1034809011460 catalytic triad [active] 1034809011461 peroxidatic and resolving cysteines [active] 1034809011463 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1034809011464 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1034809011465 catalytic residue [active] 1034809011466 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1034809011467 catalytic residues [active] 1034809011468 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1034809011469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1034809011473 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1034809011474 catalytic core [active] 1034809011476 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1034809011478 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1034809011481 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1034809011482 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1034809011483 dimer interface [polypeptide binding]; other site 1034809011484 ssDNA binding site [nucleotide binding]; other site 1034809011485 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1034809011488 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1034809011490 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1034809011491 active site 1034809011492 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1034809011494 GTP-binding protein YchF; Reviewed; Region: PRK09601 1034809011495 YchF GTPase; Region: YchF; cd01900 1034809011496 G1 box; other site 1034809011497 GTP/Mg2+ binding site [chemical binding]; other site 1034809011498 Switch I region; other site 1034809011499 G2 box; other site 1034809011500 Switch II region; other site 1034809011501 G3 box; other site 1034809011502 G4 box; other site 1034809011503 G5 box; other site 1034809011504 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1034809011508 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1034809011510 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1034809011511 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1034809011513 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1034809011514 ParB-like nuclease domain; Region: ParB; smart00470 1034809011515 predicted helix-turn-helix motif with score1963.000,SD 5.87 at aa 130-151 1034809011517 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1034809011518 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1034809011519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1034809011520 catalytic residue [active] 1034809011523 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1034809011524 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1034809011525 homodimer interface [polypeptide binding]; other site 1034809011526 substrate-cofactor binding pocket; other site 1034809011527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1034809011528 catalytic residue [active] 1034809011531 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1034809011532 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1034809011533 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1034809011534 FAD binding site [chemical binding]; other site 1034809011537 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1034809011538 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1034809011539 THF binding site; other site 1034809011540 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1034809011541 substrate binding site [chemical binding]; other site 1034809011542 THF binding site; other site 1034809011543 zinc-binding site [ion binding]; other site 1034809011546 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1034809011548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1034809011549 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1034809011551 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1034809011552 Nucleoside recognition; Region: Gate; pfam07670 1034809011553 Nucleoside recognition; Region: Gate; pfam07670 1034809011558 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1034809011559 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1034809011560 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1034809011564 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1034809011565 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1034809011566 FtsX-like permease family; Region: FtsX; pfam02687 1034809011568 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034809011569 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1034809011570 Walker A/P-loop; other site 1034809011571 ATP binding site [chemical binding]; other site 1034809011572 Q-loop/lid; other site 1034809011573 ABC transporter signature motif; other site 1034809011574 Walker B; other site 1034809011575 D-loop; other site 1034809011576 H-loop/switch region; other site 1034809011580 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1034809011581 HlyD family secretion protein; Region: HlyD_3; pfam13437 1034809011582 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1034809011583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1034809011584 active site 1034809011586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1034809011587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1034809011588 dimer interface [polypeptide binding]; other site 1034809011589 phosphorylation site [posttranslational modification] 1034809011590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1034809011591 ATP binding site [chemical binding]; other site 1034809011592 Mg2+ binding site [ion binding]; other site 1034809011593 G-X-G motif; other site 1034809011596 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1034809011597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1034809011598 Walker A/P-loop; other site 1034809011599 ATP binding site [chemical binding]; other site 1034809011600 Q-loop/lid; other site 1034809011601 ABC transporter signature motif; other site 1034809011602 Walker B; other site 1034809011603 D-loop; other site 1034809011604 H-loop/switch region; other site 1034809011608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1034809011609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1034809011610 active site 1034809011611 phosphorylation site [posttranslational modification] 1034809011612 intermolecular recognition site; other site 1034809011613 dimerization interface [polypeptide binding]; other site 1034809011614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1034809011615 DNA binding site [nucleotide binding] 1034809011618 galactoside permease; Reviewed; Region: lacY; PRK09528 1034809011621 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1034809011622 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1034809011623 substrate binding [chemical binding]; other site 1034809011624 active site 1034809011625 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1034809011629 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1034809011630 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1034809011631 DNA binding site [nucleotide binding] 1034809011632 domain linker motif; other site 1034809011633 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1034809011634 dimerization interface [polypeptide binding]; other site 1034809011635 ligand binding site [chemical binding]; other site 1034809011636 sodium binding site [ion binding]; other site 1034809011638 predicted helix-turn-helix motif with score1634.000,SD 4.75 at aa 3-24 1034809011640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1034809011643 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1034809011644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1034809011646 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1034809011647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809011648 putative substrate translocation pore; other site 1034809011649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809011653 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1034809011654 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1034809011655 Catalytic site [active] 1034809011660 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1034809011661 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1034809011662 Walker A/P-loop; other site 1034809011663 ATP binding site [chemical binding]; other site 1034809011664 Q-loop/lid; other site 1034809011665 ABC transporter signature motif; other site 1034809011666 Walker B; other site 1034809011667 D-loop; other site 1034809011668 H-loop/switch region; other site 1034809011674 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1034809011675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1034809011676 non-specific DNA binding site [nucleotide binding]; other site 1034809011677 salt bridge; other site 1034809011678 sequence-specific DNA binding site [nucleotide binding]; other site 1034809011680 predicted helix-turn-helix motif with score2447.000,SD 7.52 at aa 17-38 1034809011681 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1034809011683 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1034809011684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1034809011685 NAD(P) binding site [chemical binding]; other site 1034809011686 active site 1034809011689 polyol permease family; Region: 2A0118; TIGR00897 1034809011690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1034809011691 putative substrate translocation pore; other site 1034809011693 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1034809011694 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1034809011695 putative N- and C-terminal domain interface [polypeptide binding]; other site 1034809011696 putative active site [active] 1034809011697 MgATP binding site [chemical binding]; other site 1034809011698 catalytic site [active] 1034809011699 metal binding site [ion binding]; metal-binding site 1034809011700 putative carbohydrate binding site [chemical binding]; other site 1034809011702 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1034809011703 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1034809011704 inhibitor binding site; inhibition site 1034809011705 catalytic Zn binding site [ion binding]; other site 1034809011706 structural Zn binding site [ion binding]; other site 1034809011707 NADP binding site [chemical binding]; other site 1034809011708 tetramer interface [polypeptide binding]; other site 1034809011712 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1034809011713 DNA-binding interface [nucleotide binding]; DNA binding site 1034809011714 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1034809011716 predicted helix-turn-helix motif with score2103.000,SD 6.35 at aa 30-51 1034809011717 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1034809011718 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1034809011720 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1034809011721 ParB-like nuclease domain; Region: ParBc; pfam02195 1034809011723 predicted helix-turn-helix motif with score1898.000,SD 5.65 at aa 143-164 1034809011725 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1034809011726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1034809011727 S-adenosylmethionine binding site [chemical binding]; other site 1034809011729 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1034809011730 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1034809011731 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1034809011732 predicted helix-turn-helix motif with score1116.000,SD 2.99 at aa 592-613 1034809011735 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1034809011736 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1034809011737 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1034809011738 G1 box; other site 1034809011739 GTP/Mg2+ binding site [chemical binding]; other site 1034809011740 Switch I region; other site 1034809011741 G2 box; other site 1034809011742 Switch II region; other site 1034809011743 G3 box; other site 1034809011744 G4 box; other site 1034809011745 G5 box; other site 1034809011746 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1034809011750 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1034809011753 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399