-- dump date 20140620_075958 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698737000001 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 698737000002 Uncharacterized conserved protein [Function unknown]; Region: COG2128 698737000003 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 698737000004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737000005 putative DNA binding site [nucleotide binding]; other site 698737000006 putative Zn2+ binding site [ion binding]; other site 698737000007 AsnC family; Region: AsnC_trans_reg; pfam01037 698737000008 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 698737000009 putative catalytic site [active] 698737000010 metal binding site A [ion binding]; metal-binding site 698737000011 phosphate binding site [ion binding]; other site 698737000012 metal binding site C [ion binding]; metal-binding site 698737000013 metal binding site B [ion binding]; metal-binding site 698737000014 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737000015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737000016 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 698737000017 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698737000018 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 698737000019 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698737000020 putative NAD(P) binding site [chemical binding]; other site 698737000021 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 698737000022 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698737000023 FMN binding site [chemical binding]; other site 698737000024 active site 698737000025 catalytic residues [active] 698737000026 substrate binding site [chemical binding]; other site 698737000027 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737000029 Walker A/P-loop; other site 698737000030 ATP binding site [chemical binding]; other site 698737000031 Q-loop/lid; other site 698737000032 ABC transporter signature motif; other site 698737000033 Walker B; other site 698737000034 D-loop; other site 698737000035 H-loop/switch region; other site 698737000036 potential frameshift: common BLAST hit: gi|226223712|ref|YP_002757819.1| streptolysin S associated ORF sagB 698737000037 FMN binding site [chemical binding]; other site 698737000038 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698737000039 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 698737000040 putative FMN binding site [chemical binding]; other site 698737000041 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 698737000042 YcaO-like family; Region: YcaO; pfam02624 698737000043 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 698737000044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737000045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737000046 phosphorylation site [posttranslational modification] 698737000047 dimer interface [polypeptide binding]; other site 698737000048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737000049 ATP binding site [chemical binding]; other site 698737000050 Mg2+ binding site [ion binding]; other site 698737000051 G-X-G motif; other site 698737000052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737000053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737000054 active site 698737000055 phosphorylation site [posttranslational modification] 698737000056 intermolecular recognition site; other site 698737000057 dimerization interface [polypeptide binding]; other site 698737000058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737000059 DNA binding site [nucleotide binding] 698737000060 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737000061 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 698737000062 Walker A/P-loop; other site 698737000063 ATP binding site [chemical binding]; other site 698737000064 Q-loop/lid; other site 698737000065 ABC transporter signature motif; other site 698737000066 Walker B; other site 698737000067 D-loop; other site 698737000068 H-loop/switch region; other site 698737000069 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 698737000070 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 698737000071 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 698737000072 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 698737000073 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 698737000074 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 698737000075 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 698737000076 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 698737000077 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 698737000078 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 698737000079 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 698737000080 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 698737000081 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698737000082 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 698737000083 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698737000084 acyl-activating enzyme (AAE) consensus motif; other site 698737000085 AMP binding site [chemical binding]; other site 698737000086 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737000087 Condensation domain; Region: Condensation; pfam00668 698737000088 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737000089 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 698737000090 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 698737000091 acyl-activating enzyme (AAE) consensus motif; other site 698737000092 AMP binding site [chemical binding]; other site 698737000093 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737000094 thioester reductase domain; Region: Thioester-redct; TIGR01746 698737000095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000096 NAD(P) binding site [chemical binding]; other site 698737000097 active site 698737000098 Protein of unknown function, DUF576; Region: DUF576; cl04553 698737000099 Protein of unknown function, DUF576; Region: DUF576; cl04553 698737000100 Protein of unknown function, DUF576; Region: DUF576; pfam04507 698737000101 Protein of unknown function, DUF576; Region: DUF576; pfam04507 698737000102 Protein of unknown function, DUF576; Region: DUF576; pfam04507 698737000103 Protein of unknown function, DUF576; Region: DUF576; pfam04507 698737000104 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 698737000105 nucleophilic elbow; other site 698737000106 catalytic triad; other site 698737000107 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698737000108 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698737000109 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737000110 NAD binding site [chemical binding]; other site 698737000111 dimer interface [polypeptide binding]; other site 698737000112 substrate binding site [chemical binding]; other site 698737000113 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698737000114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737000115 DNA-binding site [nucleotide binding]; DNA binding site 698737000116 UTRA domain; Region: UTRA; pfam07702 698737000117 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 698737000118 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698737000119 dimer interface [polypeptide binding]; other site 698737000120 active site 698737000121 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 698737000122 Class I aldolases; Region: Aldolase_Class_I; cl17187 698737000123 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 698737000124 active site 698737000125 phosphorylation site [posttranslational modification] 698737000126 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 698737000127 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 698737000128 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 698737000129 active pocket/dimerization site; other site 698737000130 active site 698737000131 phosphorylation site [posttranslational modification] 698737000132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737000133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737000134 active site 698737000135 phosphorylation site [posttranslational modification] 698737000136 intermolecular recognition site; other site 698737000137 dimerization interface [polypeptide binding]; other site 698737000138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737000139 DNA binding site [nucleotide binding] 698737000140 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 698737000141 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 698737000142 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 698737000143 Ligand Binding Site [chemical binding]; other site 698737000144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737000145 dimer interface [polypeptide binding]; other site 698737000146 phosphorylation site [posttranslational modification] 698737000147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737000148 ATP binding site [chemical binding]; other site 698737000149 Mg2+ binding site [ion binding]; other site 698737000150 G-X-G motif; other site 698737000151 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 698737000152 potassium-transporting ATPase subunit B; Provisional; Region: PRK14010 698737000153 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698737000154 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698737000155 potassium-transporting ATPase subunit C; Provisional; Region: PRK14000 698737000156 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 698737000157 NEAr Transporter domain; Region: NEAT; smart00725 698737000158 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000159 heme-binding site [chemical binding]; other site 698737000160 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 698737000161 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 698737000162 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698737000163 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000164 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698737000165 Walker A/P-loop; other site 698737000166 ATP binding site [chemical binding]; other site 698737000167 Q-loop/lid; other site 698737000168 ABC transporter signature motif; other site 698737000169 Walker B; other site 698737000170 D-loop; other site 698737000171 H-loop/switch region; other site 698737000172 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737000174 Walker A/P-loop; other site 698737000175 ATP binding site [chemical binding]; other site 698737000176 Q-loop/lid; other site 698737000177 ABC transporter signature motif; other site 698737000178 Walker B; other site 698737000179 D-loop; other site 698737000180 H-loop/switch region; other site 698737000181 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 698737000182 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000183 heme-binding site [chemical binding]; other site 698737000184 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000185 heme-binding site [chemical binding]; other site 698737000186 heme uptake protein IsdC; Region: IsdC; TIGR03656 698737000187 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000188 heme-binding site [chemical binding]; other site 698737000189 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 698737000190 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000191 heme-binding site [chemical binding]; other site 698737000192 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 698737000193 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737000194 intersubunit interface [polypeptide binding]; other site 698737000195 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698737000196 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000197 ABC-ATPase subunit interface; other site 698737000198 dimer interface [polypeptide binding]; other site 698737000199 putative PBP binding regions; other site 698737000200 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698737000201 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737000202 Walker A/P-loop; other site 698737000203 ATP binding site [chemical binding]; other site 698737000204 Q-loop/lid; other site 698737000205 ABC transporter signature motif; other site 698737000206 Walker B; other site 698737000207 D-loop; other site 698737000208 H-loop/switch region; other site 698737000209 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 698737000210 active site 698737000211 catalytic site [active] 698737000212 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 698737000213 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 698737000214 CHAP domain; Region: CHAP; pfam05257 698737000215 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698737000216 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000217 ABC-ATPase subunit interface; other site 698737000218 dimer interface [polypeptide binding]; other site 698737000219 putative PBP binding regions; other site 698737000220 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698737000221 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000222 ABC-ATPase subunit interface; other site 698737000223 dimer interface [polypeptide binding]; other site 698737000224 putative PBP binding regions; other site 698737000225 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698737000226 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698737000227 siderophore binding site; other site 698737000228 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 698737000229 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 698737000230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737000231 Coenzyme A binding pocket [chemical binding]; other site 698737000232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698737000233 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698737000234 MarR family; Region: MarR; pfam01047 698737000235 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698737000236 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698737000237 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698737000238 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698737000239 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698737000240 Walker A/P-loop; other site 698737000241 ATP binding site [chemical binding]; other site 698737000242 Q-loop/lid; other site 698737000243 ABC transporter signature motif; other site 698737000244 Walker B; other site 698737000245 D-loop; other site 698737000246 H-loop/switch region; other site 698737000247 TOBE domain; Region: TOBE_2; pfam08402 698737000248 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698737000249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000250 dimer interface [polypeptide binding]; other site 698737000251 conserved gate region; other site 698737000252 ABC-ATPase subunit interface; other site 698737000253 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698737000254 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698737000255 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698737000256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000257 dimer interface [polypeptide binding]; other site 698737000258 conserved gate region; other site 698737000259 putative PBP binding loops; other site 698737000260 ABC-ATPase subunit interface; other site 698737000261 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 698737000262 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737000263 putative active site [active] 698737000264 putative metal binding site [ion binding]; other site 698737000265 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 698737000266 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 698737000267 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698737000268 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 698737000269 potassium-transporting ATPase subunit B; Provisional; Region: PRK14010 698737000270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698737000271 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698737000272 potassium-transporting ATPase subunit C; Provisional; Region: PRK14000 698737000273 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 698737000274 NEAr Transporter domain; Region: NEAT; smart00725 698737000275 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000276 heme-binding site [chemical binding]; other site 698737000277 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 698737000278 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 698737000279 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698737000280 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000281 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698737000282 Walker A/P-loop; other site 698737000283 ATP binding site [chemical binding]; other site 698737000284 Q-loop/lid; other site 698737000285 ABC transporter signature motif; other site 698737000286 Walker B; other site 698737000287 D-loop; other site 698737000288 H-loop/switch region; other site 698737000289 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737000290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737000291 Walker A/P-loop; other site 698737000292 ATP binding site [chemical binding]; other site 698737000293 Q-loop/lid; other site 698737000294 ABC transporter signature motif; other site 698737000295 Walker B; other site 698737000296 D-loop; other site 698737000297 H-loop/switch region; other site 698737000298 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 698737000299 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000300 heme-binding site [chemical binding]; other site 698737000301 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000302 heme-binding site [chemical binding]; other site 698737000303 heme uptake protein IsdC; Region: IsdC; TIGR03656 698737000304 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000305 heme-binding site [chemical binding]; other site 698737000306 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 698737000307 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 698737000308 heme-binding site [chemical binding]; other site 698737000309 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 698737000310 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737000311 intersubunit interface [polypeptide binding]; other site 698737000312 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698737000313 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000314 ABC-ATPase subunit interface; other site 698737000315 dimer interface [polypeptide binding]; other site 698737000316 putative PBP binding regions; other site 698737000317 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698737000318 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737000319 Walker A/P-loop; other site 698737000320 ATP binding site [chemical binding]; other site 698737000321 Q-loop/lid; other site 698737000322 ABC transporter signature motif; other site 698737000323 Walker B; other site 698737000324 D-loop; other site 698737000325 H-loop/switch region; other site 698737000326 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 698737000327 active site 698737000328 catalytic site [active] 698737000329 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 698737000330 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 698737000331 CHAP domain; Region: CHAP; pfam05257 698737000332 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698737000333 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000334 ABC-ATPase subunit interface; other site 698737000335 dimer interface [polypeptide binding]; other site 698737000336 putative PBP binding regions; other site 698737000337 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698737000338 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737000339 ABC-ATPase subunit interface; other site 698737000340 dimer interface [polypeptide binding]; other site 698737000341 putative PBP binding regions; other site 698737000342 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698737000343 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698737000344 siderophore binding site; other site 698737000345 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 698737000346 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 698737000347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737000348 Coenzyme A binding pocket [chemical binding]; other site 698737000349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698737000350 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698737000351 MarR family; Region: MarR; pfam01047 698737000352 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698737000353 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698737000354 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698737000355 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698737000356 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 698737000357 Walker A/P-loop; other site 698737000358 ATP binding site [chemical binding]; other site 698737000359 Q-loop/lid; other site 698737000360 ABC transporter signature motif; other site 698737000361 Walker B; other site 698737000362 D-loop; other site 698737000363 H-loop/switch region; other site 698737000364 TOBE domain; Region: TOBE_2; pfam08402 698737000365 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698737000366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000367 dimer interface [polypeptide binding]; other site 698737000368 conserved gate region; other site 698737000369 ABC-ATPase subunit interface; other site 698737000370 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 698737000371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 698737000372 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 698737000373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000374 dimer interface [polypeptide binding]; other site 698737000375 conserved gate region; other site 698737000376 putative PBP binding loops; other site 698737000377 ABC-ATPase subunit interface; other site 698737000378 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 698737000379 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737000380 putative active site [active] 698737000381 putative metal binding site [ion binding]; other site 698737000382 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 698737000383 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698737000384 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 698737000385 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698737000386 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 698737000387 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698737000388 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737000389 catalytic core [active] 698737000390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737000391 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698737000392 dimerization interface [polypeptide binding]; other site 698737000393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737000394 dimer interface [polypeptide binding]; other site 698737000395 phosphorylation site [posttranslational modification] 698737000396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737000397 ATP binding site [chemical binding]; other site 698737000398 Mg2+ binding site [ion binding]; other site 698737000399 G-X-G motif; other site 698737000400 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737000401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737000402 active site 698737000403 phosphorylation site [posttranslational modification] 698737000404 intermolecular recognition site; other site 698737000405 dimerization interface [polypeptide binding]; other site 698737000406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737000407 DNA binding site [nucleotide binding] 698737000408 DoxX; Region: DoxX; pfam07681 698737000409 Electron transfer DM13; Region: DM13; cl02735 698737000410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737000411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698737000412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698737000413 dimerization interface [polypeptide binding]; other site 698737000414 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698737000415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737000416 Walker A/P-loop; other site 698737000417 ATP binding site [chemical binding]; other site 698737000418 Q-loop/lid; other site 698737000419 ABC transporter signature motif; other site 698737000420 Walker B; other site 698737000421 D-loop; other site 698737000422 H-loop/switch region; other site 698737000423 TOBE domain; Region: TOBE_2; pfam08402 698737000424 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698737000425 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 698737000426 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 698737000427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000428 dimer interface [polypeptide binding]; other site 698737000429 conserved gate region; other site 698737000430 putative PBP binding loops; other site 698737000431 ABC-ATPase subunit interface; other site 698737000432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000433 dimer interface [polypeptide binding]; other site 698737000434 conserved gate region; other site 698737000435 putative PBP binding loops; other site 698737000436 ABC-ATPase subunit interface; other site 698737000437 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 698737000438 active site 698737000439 metal binding site [ion binding]; metal-binding site 698737000440 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698737000441 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 698737000442 Bacterial transcriptional regulator; Region: IclR; pfam01614 698737000443 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 698737000444 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698737000445 substrate binding site [chemical binding]; other site 698737000446 ATP binding site [chemical binding]; other site 698737000447 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 698737000448 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 698737000449 active site 698737000450 intersubunit interface [polypeptide binding]; other site 698737000451 catalytic residue [active] 698737000452 galactonate dehydratase; Provisional; Region: PRK14017 698737000453 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 698737000454 putative active site pocket [active] 698737000455 putative metal binding site [ion binding]; other site 698737000456 gluconate transporter; Region: gntP; TIGR00791 698737000457 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698737000458 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 698737000459 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698737000460 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698737000461 DNA binding residues [nucleotide binding] 698737000462 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 698737000463 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 698737000464 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698737000465 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698737000466 active site 698737000467 dimer interface [polypeptide binding]; other site 698737000468 motif 1; other site 698737000469 motif 2; other site 698737000470 motif 3; other site 698737000471 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698737000472 anticodon binding site; other site 698737000473 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698737000474 hypothetical protein; Provisional; Region: PRK06184 698737000475 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 698737000476 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 698737000477 stage V sporulation protein K; Region: spore_V_K; TIGR02881 698737000478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737000479 Walker A motif; other site 698737000480 ATP binding site [chemical binding]; other site 698737000481 Walker B motif; other site 698737000482 arginine finger; other site 698737000483 stage V sporulation protein K; Region: spore_V_K; TIGR02881 698737000484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737000485 Walker A motif; other site 698737000486 ATP binding site [chemical binding]; other site 698737000487 Walker B motif; other site 698737000488 arginine finger; other site 698737000489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737000490 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737000491 active site 698737000492 motif I; other site 698737000493 motif II; other site 698737000494 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698737000495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000496 benzoate transport; Region: 2A0115; TIGR00895 698737000497 putative substrate translocation pore; other site 698737000498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000499 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698737000500 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 698737000501 substrate binding site [chemical binding]; other site 698737000502 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698737000503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000504 dimer interface [polypeptide binding]; other site 698737000505 conserved gate region; other site 698737000506 putative PBP binding loops; other site 698737000507 ABC-ATPase subunit interface; other site 698737000508 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698737000509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000510 dimer interface [polypeptide binding]; other site 698737000511 conserved gate region; other site 698737000512 putative PBP binding loops; other site 698737000513 ABC-ATPase subunit interface; other site 698737000514 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698737000515 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698737000516 Walker A/P-loop; other site 698737000517 ATP binding site [chemical binding]; other site 698737000518 Q-loop/lid; other site 698737000519 ABC transporter signature motif; other site 698737000520 Walker B; other site 698737000521 D-loop; other site 698737000522 H-loop/switch region; other site 698737000523 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698737000524 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698737000525 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698737000526 Walker A/P-loop; other site 698737000527 ATP binding site [chemical binding]; other site 698737000528 Q-loop/lid; other site 698737000529 ABC transporter signature motif; other site 698737000530 Walker B; other site 698737000531 D-loop; other site 698737000532 H-loop/switch region; other site 698737000533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737000534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000535 putative substrate translocation pore; other site 698737000536 Peptidase M30; Region: Peptidase_M30; pfam10460 698737000537 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 698737000538 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 698737000539 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 698737000540 conserved cys residue [active] 698737000541 amino acid transporter; Region: 2A0306; TIGR00909 698737000542 methionine sulfoxide reductase A; Provisional; Region: PRK05528 698737000543 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698737000544 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698737000545 catalytic triad [active] 698737000546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698737000547 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698737000548 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698737000549 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 698737000550 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737000551 active site turn [active] 698737000552 phosphorylation site [posttranslational modification] 698737000553 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 698737000554 HPr interaction site; other site 698737000555 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698737000556 active site 698737000557 phosphorylation site [posttranslational modification] 698737000558 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737000559 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698737000560 intersubunit interface [polypeptide binding]; other site 698737000561 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 698737000562 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 698737000563 potential frameshift: common BLAST hit: gi|224477927|ref|YP_002635533.1| penicillin binding protein 4 698737000564 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 698737000565 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698737000566 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698737000567 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 698737000568 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698737000569 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 698737000570 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737000571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737000572 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 698737000573 MMPL family; Region: MMPL; pfam03176 698737000574 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698737000575 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698737000576 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 698737000577 NADP binding site [chemical binding]; other site 698737000578 putative substrate binding site [chemical binding]; other site 698737000579 active site 698737000580 Predicted membrane protein [Function unknown]; Region: COG3212 698737000581 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 698737000582 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698737000583 Pyruvate formate lyase 1; Region: PFL1; cd01678 698737000584 coenzyme A binding site [chemical binding]; other site 698737000585 active site 698737000586 catalytic residues [active] 698737000587 glycine loop; other site 698737000588 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698737000589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737000590 FeS/SAM binding site; other site 698737000591 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698737000592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737000593 dimerization interface [polypeptide binding]; other site 698737000594 putative DNA binding site [nucleotide binding]; other site 698737000595 putative Zn2+ binding site [ion binding]; other site 698737000596 arsenical pump membrane protein; Provisional; Region: PRK15445 698737000597 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 698737000598 transmembrane helices; other site 698737000599 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 698737000600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737000601 Walker A/P-loop; other site 698737000602 ATP binding site [chemical binding]; other site 698737000603 Q-loop/lid; other site 698737000604 ABC transporter signature motif; other site 698737000605 Walker B; other site 698737000606 D-loop; other site 698737000607 H-loop/switch region; other site 698737000608 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 698737000609 acetoin reductases; Region: 23BDH; TIGR02415 698737000610 NAD binding site [chemical binding]; other site 698737000611 homotetramer interface [polypeptide binding]; other site 698737000612 homodimer interface [polypeptide binding]; other site 698737000613 active site 698737000614 substrate binding site [chemical binding]; other site 698737000615 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698737000616 DNA-binding site [nucleotide binding]; DNA binding site 698737000617 RNA-binding motif; other site 698737000618 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737000619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737000620 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 698737000621 Predicted acyl esterases [General function prediction only]; Region: COG2936 698737000622 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 698737000623 Predicted membrane protein [Function unknown]; Region: COG2311 698737000624 Protein of unknown function (DUF418); Region: DUF418; cl12135 698737000625 Protein of unknown function (DUF418); Region: DUF418; pfam04235 698737000626 TspO/MBR family; Region: TspO_MBR; pfam03073 698737000627 phytoene desaturase; Region: crtI_fam; TIGR02734 698737000628 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698737000629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737000630 active site 698737000631 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 698737000632 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698737000633 active site lid residues [active] 698737000634 substrate binding pocket [chemical binding]; other site 698737000635 catalytic residues [active] 698737000636 substrate-Mg2+ binding site; other site 698737000637 aspartate-rich region 1; other site 698737000638 aspartate-rich region 2; other site 698737000639 phytoene desaturase; Region: crtI_fam; TIGR02734 698737000640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698737000641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737000643 putative substrate translocation pore; other site 698737000644 MepB protein; Region: MepB; pfam08877 698737000645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737000646 Walker A/P-loop; other site 698737000647 ATP binding site [chemical binding]; other site 698737000648 ABC transporter; Region: ABC_tran; pfam00005 698737000649 Q-loop/lid; other site 698737000650 ABC transporter signature motif; other site 698737000651 Walker B; other site 698737000652 D-loop; other site 698737000653 H-loop/switch region; other site 698737000654 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 698737000655 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698737000656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737000657 S-adenosylmethionine binding site [chemical binding]; other site 698737000658 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698737000659 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698737000660 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698737000661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000662 dimer interface [polypeptide binding]; other site 698737000663 conserved gate region; other site 698737000664 putative PBP binding loops; other site 698737000665 ABC-ATPase subunit interface; other site 698737000666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698737000667 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698737000668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737000669 dimer interface [polypeptide binding]; other site 698737000670 conserved gate region; other site 698737000671 putative PBP binding loops; other site 698737000672 ABC-ATPase subunit interface; other site 698737000673 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698737000674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698737000675 Q-loop/lid; other site 698737000676 ABC transporter signature motif; other site 698737000677 Walker B; other site 698737000678 D-loop; other site 698737000679 H-loop/switch region; other site 698737000680 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698737000681 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737000682 Walker A/P-loop; other site 698737000683 ATP binding site [chemical binding]; other site 698737000684 Q-loop/lid; other site 698737000685 ABC transporter signature motif; other site 698737000686 Walker B; other site 698737000687 D-loop; other site 698737000688 H-loop/switch region; other site 698737000689 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 698737000690 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 698737000691 dimer interface [polypeptide binding]; other site 698737000692 PYR/PP interface [polypeptide binding]; other site 698737000693 TPP binding site [chemical binding]; other site 698737000694 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698737000695 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 698737000696 TPP-binding site [chemical binding]; other site 698737000697 dimer interface [polypeptide binding]; other site 698737000698 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698737000699 MarR family; Region: MarR_2; pfam12802 698737000700 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698737000701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737000702 Walker A/P-loop; other site 698737000703 ATP binding site [chemical binding]; other site 698737000704 Q-loop/lid; other site 698737000705 ABC transporter signature motif; other site 698737000706 Walker B; other site 698737000707 D-loop; other site 698737000708 H-loop/switch region; other site 698737000709 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 698737000710 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698737000711 Uncharacterized conserved protein [Function unknown]; Region: COG2353 698737000712 Predicted membrane protein [Function unknown]; Region: COG1288 698737000713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000714 putative substrate translocation pore; other site 698737000715 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 698737000716 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 698737000717 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 698737000718 classical (c) SDRs; Region: SDR_c; cd05233 698737000719 NAD(P) binding site [chemical binding]; other site 698737000720 active site 698737000721 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 698737000722 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698737000723 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737000724 active site turn [active] 698737000725 phosphorylation site [posttranslational modification] 698737000726 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 698737000727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737000728 NAD(P) binding site [chemical binding]; other site 698737000729 active site 698737000730 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 698737000731 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 698737000732 putative catalytic cysteine [active] 698737000733 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 698737000734 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 698737000735 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737000736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000737 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 698737000738 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698737000739 putative active site [active] 698737000740 putative FMN binding site [chemical binding]; other site 698737000741 putative substrate binding site [chemical binding]; other site 698737000742 putative catalytic residue [active] 698737000743 FMN-binding domain; Region: FMN_bind; cl01081 698737000744 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 698737000745 L-aspartate oxidase; Provisional; Region: PRK06175 698737000746 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 698737000747 ApbE family; Region: ApbE; pfam02424 698737000748 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 698737000749 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698737000750 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737000751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737000752 homodimer interface [polypeptide binding]; other site 698737000753 catalytic residue [active] 698737000754 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 698737000755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698737000756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737000757 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737000758 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 698737000759 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698737000760 tetramer interface [polypeptide binding]; other site 698737000761 TPP-binding site [chemical binding]; other site 698737000762 heterodimer interface [polypeptide binding]; other site 698737000763 phosphorylation loop region [posttranslational modification] 698737000764 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698737000765 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698737000766 alpha subunit interface [polypeptide binding]; other site 698737000767 TPP binding site [chemical binding]; other site 698737000768 heterodimer interface [polypeptide binding]; other site 698737000769 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698737000770 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 698737000771 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737000772 E3 interaction surface; other site 698737000773 lipoyl attachment site [posttranslational modification]; other site 698737000774 e3 binding domain; Region: E3_binding; pfam02817 698737000775 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698737000776 Predicted transcriptional regulators [Transcription]; Region: COG1695 698737000777 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 698737000778 hypothetical protein; Validated; Region: PRK07668 698737000779 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 698737000780 HTH domain; Region: HTH_11; pfam08279 698737000781 PRD domain; Region: PRD; pfam00874 698737000782 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 698737000783 active site 698737000784 P-loop; other site 698737000785 phosphorylation site [posttranslational modification] 698737000786 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737000787 active site 698737000788 phosphorylation site [posttranslational modification] 698737000789 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 698737000790 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 698737000791 active site 698737000792 P-loop; other site 698737000793 phosphorylation site [posttranslational modification] 698737000794 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 698737000795 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737000796 active site 698737000797 phosphorylation site [posttranslational modification] 698737000798 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 698737000799 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 698737000800 NMT1/THI5 like; Region: NMT1; pfam09084 698737000801 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737000802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737000803 non-specific DNA binding site [nucleotide binding]; other site 698737000804 salt bridge; other site 698737000805 sequence-specific DNA binding site [nucleotide binding]; other site 698737000806 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 698737000807 ornithine decarboxylase; Provisional; Region: PRK13578 698737000808 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 698737000809 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737000810 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737000811 catalytic residue [active] 698737000812 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 698737000813 putrescine-ornithine antiporter; Region: antiport_PotE; TIGR04299 698737000814 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698737000815 Cation efflux family; Region: Cation_efflux; cl00316 698737000816 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 698737000817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737000818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737000819 non-specific DNA binding site [nucleotide binding]; other site 698737000820 salt bridge; other site 698737000821 sequence-specific DNA binding site [nucleotide binding]; other site 698737000822 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 698737000823 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 698737000824 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 698737000825 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 698737000826 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 698737000827 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 698737000828 putative ADP-ribose binding site [chemical binding]; other site 698737000829 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 698737000830 lipoyl attachment site [posttranslational modification]; other site 698737000831 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698737000832 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698737000833 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698737000834 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 698737000835 putative active site [active] 698737000836 putative FMN binding site [chemical binding]; other site 698737000837 putative substrate binding site [chemical binding]; other site 698737000838 putative catalytic residue [active] 698737000839 BCCT family transporter; Region: BCCT; pfam02028 698737000840 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698737000841 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698737000842 active site 698737000843 dimer interface [polypeptide binding]; other site 698737000844 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698737000845 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698737000846 active site 698737000847 trimer interface [polypeptide binding]; other site 698737000848 allosteric site; other site 698737000849 active site lid [active] 698737000850 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698737000851 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698737000852 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698737000853 putative active site cavity [active] 698737000854 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698737000855 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698737000856 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698737000857 putative active site [active] 698737000858 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698737000859 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698737000860 nucleotide binding site [chemical binding]; other site 698737000861 N-acetylneuraminate lyase; Provisional; Region: PRK04147 698737000862 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 698737000863 inhibitor site; inhibition site 698737000864 active site 698737000865 dimer interface [polypeptide binding]; other site 698737000866 catalytic residue [active] 698737000867 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 698737000868 putative transporter; Provisional; Region: PRK10484 698737000869 Na binding site [ion binding]; other site 698737000870 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 698737000871 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698737000872 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698737000873 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698737000874 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 698737000875 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 698737000876 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698737000877 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 698737000878 substrate binding site [chemical binding]; other site 698737000879 ATP binding site [chemical binding]; other site 698737000880 CAAX protease self-immunity; Region: Abi; pfam02517 698737000881 CAAX protease self-immunity; Region: Abi; pfam02517 698737000882 CAAX protease self-immunity; Region: Abi; pfam02517 698737000883 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 698737000884 putative substrate binding pocket [chemical binding]; other site 698737000885 AC domain interface; other site 698737000886 catalytic triad [active] 698737000887 AB domain interface; other site 698737000888 interchain disulfide; other site 698737000889 Predicted membrane protein [Function unknown]; Region: COG3817 698737000890 Protein of unknown function (DUF979); Region: DUF979; pfam06166 698737000891 Protein of unknown function (DUF969); Region: DUF969; pfam06149 698737000892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737000893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737000894 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 698737000895 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 698737000896 active site 698737000897 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 698737000898 HTH domain; Region: HTH_11; cl17392 698737000899 HTH domain; Region: HTH_11; pfam08279 698737000900 PRD domain; Region: PRD; pfam00874 698737000901 PRD domain; Region: PRD; pfam00874 698737000902 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 698737000903 active site 698737000904 P-loop; other site 698737000905 phosphorylation site [posttranslational modification] 698737000906 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737000907 active site 698737000908 phosphorylation site [posttranslational modification] 698737000909 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737000910 active site 698737000911 phosphorylation site [posttranslational modification] 698737000912 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698737000913 active site 698737000914 P-loop; other site 698737000915 phosphorylation site [posttranslational modification] 698737000916 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 698737000917 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698737000918 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698737000919 active site residue [active] 698737000920 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 698737000921 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 698737000922 Strictosidine synthase; Region: Str_synth; pfam03088 698737000923 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737000924 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698737000925 active site 698737000926 metal binding site [ion binding]; metal-binding site 698737000927 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698737000928 hydrophobic ligand binding site; other site 698737000929 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698737000930 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698737000931 substrate binding site [chemical binding]; other site 698737000932 dimer interface [polypeptide binding]; other site 698737000933 ATP binding site [chemical binding]; other site 698737000934 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 698737000935 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698737000936 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698737000937 Walker A/P-loop; other site 698737000938 ATP binding site [chemical binding]; other site 698737000939 Q-loop/lid; other site 698737000940 ABC transporter signature motif; other site 698737000941 Walker B; other site 698737000942 D-loop; other site 698737000943 H-loop/switch region; other site 698737000944 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 698737000945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737000946 non-specific DNA binding site [nucleotide binding]; other site 698737000947 salt bridge; other site 698737000948 sequence-specific DNA binding site [nucleotide binding]; other site 698737000949 Tic20-like protein; Region: Tic20; pfam09685 698737000950 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698737000951 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 698737000952 NADP binding site [chemical binding]; other site 698737000953 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 698737000954 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 698737000955 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 698737000956 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 698737000957 CHAP domain; Region: CHAP; pfam05257 698737000958 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698737000959 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 698737000960 Predicted membrane protein [Function unknown]; Region: COG1511 698737000961 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698737000962 YolD-like protein; Region: YolD; pfam08863 698737000963 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 698737000964 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 698737000965 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698737000966 active site 698737000967 DNA binding site [nucleotide binding] 698737000968 Int/Topo IB signature motif; other site 698737000969 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698737000970 active site 698737000971 DNA binding site [nucleotide binding] 698737000972 Int/Topo IB signature motif; other site 698737000973 YolD-like protein; Region: YolD; pfam08863 698737000974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737000975 dimerization interface [polypeptide binding]; other site 698737000976 putative DNA binding site [nucleotide binding]; other site 698737000977 putative Zn2+ binding site [ion binding]; other site 698737000978 Predicted permeases [General function prediction only]; Region: COG0701 698737000979 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698737000980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737000981 S-adenosylmethionine binding site [chemical binding]; other site 698737000982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698737000983 arginine deiminase; Provisional; Region: PRK01388 698737000984 Predicted esterase [General function prediction only]; Region: COG0627 698737000985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 698737000986 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 698737000987 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 698737000988 putative active site [active] 698737000989 putative metal binding site [ion binding]; other site 698737000990 Protein of unknown function (DUF867); Region: DUF867; pfam05908 698737000991 azoreductase; Reviewed; Region: PRK00170 698737000992 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698737000993 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 698737000994 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 698737000995 Chain length determinant protein; Region: Wzz; cl15801 698737000996 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 698737000997 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698737000998 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 698737000999 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 698737001000 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 698737001001 NAD(P) binding site [chemical binding]; other site 698737001002 homodimer interface [polypeptide binding]; other site 698737001003 substrate binding site [chemical binding]; other site 698737001004 active site 698737001005 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 698737001006 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 698737001007 NAD(P) binding site [chemical binding]; other site 698737001008 homodimer interface [polypeptide binding]; other site 698737001009 substrate binding site [chemical binding]; other site 698737001010 active site 698737001011 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 698737001012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001013 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698737001014 NAD(P) binding site [chemical binding]; other site 698737001015 active site 698737001016 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 698737001017 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 698737001018 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 698737001019 active site 698737001020 homodimer interface [polypeptide binding]; other site 698737001021 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 698737001022 trimer interface [polypeptide binding]; other site 698737001023 active site 698737001024 substrate binding site [chemical binding]; other site 698737001025 CoA binding site [chemical binding]; other site 698737001026 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698737001027 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698737001028 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 698737001029 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698737001030 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 698737001031 Bacterial sugar transferase; Region: Bac_transf; pfam02397 698737001032 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698737001033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001034 NAD(P) binding site [chemical binding]; other site 698737001035 active site 698737001036 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 698737001037 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698737001038 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 698737001039 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 698737001040 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 698737001041 active site 698737001042 homodimer interface [polypeptide binding]; other site 698737001043 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 698737001044 dimer interface [polypeptide binding]; other site 698737001045 Alkaline phosphatase homologues; Region: alkPPc; smart00098 698737001046 active site 698737001047 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 698737001048 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737001049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737001050 active site 698737001051 phosphorylation site [posttranslational modification] 698737001052 intermolecular recognition site; other site 698737001053 dimerization interface [polypeptide binding]; other site 698737001054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737001055 DNA binding site [nucleotide binding] 698737001056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737001057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001058 ATP binding site [chemical binding]; other site 698737001059 Mg2+ binding site [ion binding]; other site 698737001060 G-X-G motif; other site 698737001061 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737001062 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698737001063 Walker A/P-loop; other site 698737001064 ATP binding site [chemical binding]; other site 698737001065 Q-loop/lid; other site 698737001066 ABC transporter signature motif; other site 698737001067 Walker B; other site 698737001068 D-loop; other site 698737001069 H-loop/switch region; other site 698737001070 FtsX-like permease family; Region: FtsX; pfam02687 698737001071 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 698737001072 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 698737001073 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 698737001074 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 698737001075 active site 698737001076 non-prolyl cis peptide bond; other site 698737001077 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 698737001078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001079 NAD(P) binding site [chemical binding]; other site 698737001080 active site 698737001081 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 698737001082 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 698737001083 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001084 Ca2+ binding site [ion binding]; other site 698737001085 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001086 Ca2+ binding site [ion binding]; other site 698737001087 Cadherin repeat-like domain; Region: CA_like; cl15786 698737001088 Ca2+ binding site [ion binding]; other site 698737001089 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 698737001090 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 698737001091 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 698737001092 Cna protein B-type domain; Region: Cna_B; pfam05738 698737001093 Cna protein B-type domain; Region: Cna_B; pfam05738 698737001094 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 698737001095 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 698737001096 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 698737001097 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 698737001098 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 698737001099 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 698737001100 Active Sites [active] 698737001101 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 698737001102 Flavodoxin; Region: Flavodoxin_1; pfam00258 698737001103 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 698737001104 FAD binding pocket [chemical binding]; other site 698737001105 FAD binding motif [chemical binding]; other site 698737001106 catalytic residues [active] 698737001107 NAD binding pocket [chemical binding]; other site 698737001108 phosphate binding motif [ion binding]; other site 698737001109 beta-alpha-beta structure motif; other site 698737001110 sulfite reductase subunit beta; Provisional; Region: PRK13504 698737001111 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698737001112 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698737001113 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698737001114 active site 698737001115 SAM binding site [chemical binding]; other site 698737001116 homodimer interface [polypeptide binding]; other site 698737001117 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 698737001118 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 698737001119 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698737001120 Rifin/stevor family; Region: Rifin_STEVOR; cl14106 698737001121 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 698737001122 ATP-sulfurylase; Region: ATPS; cd00517 698737001123 active site 698737001124 HXXH motif; other site 698737001125 flexible loop; other site 698737001126 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 698737001127 ligand-binding site [chemical binding]; other site 698737001128 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 698737001129 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 698737001130 metal binding site [ion binding]; metal-binding site 698737001131 dimer interface [polypeptide binding]; other site 698737001132 CHAP domain; Region: CHAP; pfam05257 698737001133 Surface antigen [General function prediction only]; Region: COG3942 698737001134 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 698737001135 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698737001136 effector binding site; other site 698737001137 active site 698737001138 Zn binding site [ion binding]; other site 698737001139 glycine loop; other site 698737001140 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 698737001141 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 698737001142 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 698737001143 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 698737001144 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 698737001145 Predicted transcriptional regulators [Transcription]; Region: COG1510 698737001146 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 698737001147 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 698737001148 tetramerization interface [polypeptide binding]; other site 698737001149 NAD(P) binding site [chemical binding]; other site 698737001150 catalytic residues [active] 698737001151 choline dehydrogenase; Validated; Region: PRK02106 698737001152 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698737001153 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698737001154 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 698737001155 metal binding site [ion binding]; metal-binding site 698737001156 dimer interface [polypeptide binding]; other site 698737001157 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 698737001158 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 698737001159 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 698737001160 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 698737001161 active site 698737001162 acyl-activating enzyme (AAE) consensus motif; other site 698737001163 putative CoA binding site [chemical binding]; other site 698737001164 AMP binding site [chemical binding]; other site 698737001165 pyruvate phosphate dikinase; Provisional; Region: PRK09279 698737001166 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 698737001167 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698737001168 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698737001169 PEP synthetase regulatory protein; Provisional; Region: PRK05339 698737001170 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 698737001171 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698737001172 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698737001173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737001174 DNA-binding site [nucleotide binding]; DNA binding site 698737001175 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 698737001176 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737001177 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698737001178 active site turn [active] 698737001179 phosphorylation site [posttranslational modification] 698737001180 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698737001181 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698737001182 HPr interaction site; other site 698737001183 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698737001184 active site 698737001185 phosphorylation site [posttranslational modification] 698737001186 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 698737001187 beta-galactosidase; Region: BGL; TIGR03356 698737001188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737001189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698737001190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698737001191 dimerization interface [polypeptide binding]; other site 698737001192 Predicted transcriptional regulators [Transcription]; Region: COG1695 698737001193 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 698737001194 hypothetical protein; Provisional; Region: PRK07236 698737001195 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 698737001196 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698737001197 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 698737001198 catalytic residue [active] 698737001199 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 698737001200 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698737001201 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698737001202 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 698737001203 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698737001204 inhibitor-cofactor binding pocket; inhibition site 698737001205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737001206 catalytic residue [active] 698737001207 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698737001208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737001209 active site 698737001210 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698737001211 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737001212 active site 698737001213 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698737001214 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737001215 amino acid transporter; Region: 2A0306; TIGR00909 698737001216 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 698737001217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737001218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698737001219 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 698737001220 putative dimerization interface [polypeptide binding]; other site 698737001221 acetolactate synthase; Reviewed; Region: PRK08617 698737001222 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698737001223 PYR/PP interface [polypeptide binding]; other site 698737001224 dimer interface [polypeptide binding]; other site 698737001225 TPP binding site [chemical binding]; other site 698737001226 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698737001227 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 698737001228 TPP-binding site [chemical binding]; other site 698737001229 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 698737001230 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698737001231 L-lactate permease; Region: Lactate_perm; cl00701 698737001232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 698737001233 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 698737001234 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698737001235 quinone interaction residues [chemical binding]; other site 698737001236 active site 698737001237 catalytic residues [active] 698737001238 FMN binding site [chemical binding]; other site 698737001239 substrate binding site [chemical binding]; other site 698737001240 Phosphotransferase enzyme family; Region: APH; pfam01636 698737001241 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 698737001242 active site 698737001243 ATP binding site [chemical binding]; other site 698737001244 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 698737001245 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698737001246 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 698737001247 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 698737001248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001249 NAD(P) binding site [chemical binding]; other site 698737001250 active site 698737001251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737001252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737001253 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 698737001254 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 698737001255 NmrA-like family; Region: NmrA; pfam05368 698737001256 NADP binding site [chemical binding]; other site 698737001257 active site 698737001258 regulatory binding site [polypeptide binding]; other site 698737001259 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 698737001260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737001261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 698737001262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737001263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737001264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001265 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737001266 putative substrate translocation pore; other site 698737001267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737001269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737001270 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698737001271 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 698737001272 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 698737001273 Uncharacterized conserved protein [Function unknown]; Region: COG3189 698737001274 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 698737001275 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 698737001276 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 698737001277 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698737001278 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698737001279 catalytic residue [active] 698737001280 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 698737001281 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698737001282 catalytic triad [active] 698737001283 catalytic triad [active] 698737001284 oxyanion hole [active] 698737001285 transaminase; Reviewed; Region: PRK08068 698737001286 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737001287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737001288 homodimer interface [polypeptide binding]; other site 698737001289 catalytic residue [active] 698737001290 D-lactate dehydrogenase; Validated; Region: PRK08605 698737001291 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 698737001292 homodimer interface [polypeptide binding]; other site 698737001293 ligand binding site [chemical binding]; other site 698737001294 NAD binding site [chemical binding]; other site 698737001295 catalytic site [active] 698737001296 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698737001297 metal-binding site [ion binding] 698737001298 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698737001299 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698737001300 metal-binding site [ion binding] 698737001301 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698737001302 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698737001303 metal-binding site [ion binding] 698737001304 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698737001305 Soluble P-type ATPase [General function prediction only]; Region: COG4087 698737001306 maltose O-acetyltransferase; Provisional; Region: PRK10092 698737001307 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698737001308 active site 698737001309 substrate binding site [chemical binding]; other site 698737001310 trimer interface [polypeptide binding]; other site 698737001311 CoA binding site [chemical binding]; other site 698737001312 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698737001313 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737001314 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 698737001315 putative ADP-binding pocket [chemical binding]; other site 698737001316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698737001317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698737001318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001319 NAD(P) binding site [chemical binding]; other site 698737001320 active site 698737001321 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 698737001322 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 698737001323 Glutamate binding site [chemical binding]; other site 698737001324 homodimer interface [polypeptide binding]; other site 698737001325 NAD binding site [chemical binding]; other site 698737001326 catalytic residues [active] 698737001327 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737001328 MMPL family; Region: MMPL; pfam03176 698737001329 MMPL family; Region: MMPL; pfam03176 698737001330 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 698737001331 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 698737001332 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 698737001333 oligomer interface [polypeptide binding]; other site 698737001334 metal binding site [ion binding]; metal-binding site 698737001335 metal binding site [ion binding]; metal-binding site 698737001336 putative Cl binding site [ion binding]; other site 698737001337 aspartate ring; other site 698737001338 basic sphincter; other site 698737001339 hydrophobic gate; other site 698737001340 periplasmic entrance; other site 698737001341 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 698737001342 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 698737001343 DNA binding site [nucleotide binding] 698737001344 active site 698737001345 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 698737001346 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 698737001347 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698737001348 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 698737001349 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698737001350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737001351 Walker A/P-loop; other site 698737001352 ATP binding site [chemical binding]; other site 698737001353 Q-loop/lid; other site 698737001354 ABC transporter signature motif; other site 698737001355 Walker B; other site 698737001356 D-loop; other site 698737001357 H-loop/switch region; other site 698737001358 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737001359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737001360 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 698737001361 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 698737001362 dimer interface [polypeptide binding]; other site 698737001363 active site 698737001364 putative acyltransferase; Provisional; Region: PRK05790 698737001365 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698737001366 dimer interface [polypeptide binding]; other site 698737001367 active site 698737001368 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 698737001369 homodimer interface [polypeptide binding]; other site 698737001370 catalytic residues [active] 698737001371 NAD binding site [chemical binding]; other site 698737001372 substrate binding pocket [chemical binding]; other site 698737001373 flexible flap; other site 698737001374 Surface antigen [General function prediction only]; Region: COG3942 698737001375 CHAP domain; Region: CHAP; pfam05257 698737001376 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 698737001377 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737001378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698737001379 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 698737001380 putative dimerization interface [polypeptide binding]; other site 698737001381 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 698737001382 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 698737001383 pyruvate oxidase; Provisional; Region: PRK08611 698737001384 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698737001385 PYR/PP interface [polypeptide binding]; other site 698737001386 tetramer interface [polypeptide binding]; other site 698737001387 dimer interface [polypeptide binding]; other site 698737001388 TPP binding site [chemical binding]; other site 698737001389 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698737001390 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698737001391 TPP-binding site [chemical binding]; other site 698737001392 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 698737001393 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698737001394 catalytic Zn binding site [ion binding]; other site 698737001395 structural Zn binding site [ion binding]; other site 698737001396 NAD(P) binding site [chemical binding]; other site 698737001397 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698737001398 active site 698737001399 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737001400 catalytic residues [active] 698737001401 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698737001402 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698737001403 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737001404 NAD binding site [chemical binding]; other site 698737001405 dimer interface [polypeptide binding]; other site 698737001406 substrate binding site [chemical binding]; other site 698737001407 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698737001408 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 698737001409 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 698737001410 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737001411 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 698737001412 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 698737001413 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 698737001414 putative active site [active] 698737001415 putative metal binding site [ion binding]; other site 698737001416 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 698737001417 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 698737001418 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 698737001419 N- and C-terminal domain interface [polypeptide binding]; other site 698737001420 D-xylulose kinase; Region: XylB; TIGR01312 698737001421 active site 698737001422 MgATP binding site [chemical binding]; other site 698737001423 catalytic site [active] 698737001424 metal binding site [ion binding]; metal-binding site 698737001425 xylulose binding site [chemical binding]; other site 698737001426 homodimer interface [polypeptide binding]; other site 698737001427 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 698737001428 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 698737001429 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 698737001430 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698737001431 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 698737001432 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 698737001433 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698737001434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737001435 Coenzyme A binding pocket [chemical binding]; other site 698737001436 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 698737001437 active site 698737001438 catalytic site [active] 698737001439 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 698737001440 G5 domain; Region: G5; pfam07501 698737001441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737001442 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737001443 active site 698737001444 motif I; other site 698737001445 motif II; other site 698737001446 Transposase IS200 like; Region: Y1_Tnp; pfam01797 698737001447 D-lactate dehydrogenase; Provisional; Region: PRK12480 698737001448 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 698737001449 homodimer interface [polypeptide binding]; other site 698737001450 ligand binding site [chemical binding]; other site 698737001451 NAD binding site [chemical binding]; other site 698737001452 catalytic site [active] 698737001453 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 698737001454 dimer interface [polypeptide binding]; other site 698737001455 FMN binding site [chemical binding]; other site 698737001456 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 698737001457 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 698737001458 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698737001459 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698737001460 NAD(P) binding site [chemical binding]; other site 698737001461 catalytic residues [active] 698737001462 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 698737001463 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 698737001464 putative metal binding site [ion binding]; other site 698737001465 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737001466 active site 698737001467 Predicted acetyltransferase [General function prediction only]; Region: COG2388 698737001468 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 698737001469 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737001470 MarR family; Region: MarR; pfam01047 698737001471 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698737001472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737001473 Zn binding site [ion binding]; other site 698737001474 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698737001475 Zn binding site [ion binding]; other site 698737001476 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 698737001477 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737001478 Zn binding site [ion binding]; other site 698737001479 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 698737001480 Zn binding site [ion binding]; other site 698737001481 Predicted esterase [General function prediction only]; Region: COG0400 698737001482 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698737001483 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698737001484 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698737001485 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 698737001486 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698737001487 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698737001488 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 698737001489 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698737001490 ATP binding site [chemical binding]; other site 698737001491 substrate interface [chemical binding]; other site 698737001492 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698737001493 ThiS interaction site; other site 698737001494 putative active site [active] 698737001495 tetramer interface [polypeptide binding]; other site 698737001496 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 698737001497 thiS-thiF/thiG interaction site; other site 698737001498 hydroxyglutarate oxidase; Provisional; Region: PRK11728 698737001499 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698737001500 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698737001501 thiamine phosphate binding site [chemical binding]; other site 698737001502 active site 698737001503 pyrophosphate binding site [ion binding]; other site 698737001504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001505 D-galactonate transporter; Region: 2A0114; TIGR00893 698737001506 putative substrate translocation pore; other site 698737001507 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698737001508 Predicted membrane protein [Function unknown]; Region: COG1289 698737001509 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 698737001510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 698737001511 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698737001512 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698737001513 synthetase active site [active] 698737001514 NTP binding site [chemical binding]; other site 698737001515 metal binding site [ion binding]; metal-binding site 698737001516 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698737001517 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 698737001518 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 698737001519 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 698737001520 DNA binding residues [nucleotide binding] 698737001521 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 698737001522 Transcriptional regulators [Transcription]; Region: GntR; COG1802 698737001523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737001524 DNA-binding site [nucleotide binding]; DNA binding site 698737001525 FCD domain; Region: FCD; pfam07729 698737001526 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 698737001527 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 698737001528 N- and C-terminal domain interface [polypeptide binding]; other site 698737001529 active site 698737001530 catalytic site [active] 698737001531 metal binding site [ion binding]; metal-binding site 698737001532 carbohydrate binding site [chemical binding]; other site 698737001533 ATP binding site [chemical binding]; other site 698737001534 GntP family permease; Region: GntP_permease; pfam02447 698737001535 fructuronate transporter; Provisional; Region: PRK10034; cl15264 698737001536 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698737001537 active site 698737001538 tetramer interface; other site 698737001539 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 698737001540 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698737001541 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698737001542 active site 698737001543 substrate binding site [chemical binding]; other site 698737001544 metal binding site [ion binding]; metal-binding site 698737001545 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 698737001546 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698737001547 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 698737001548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698737001549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737001550 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737001551 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 698737001552 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698737001553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001554 NAD(P) binding site [chemical binding]; other site 698737001555 active site 698737001556 acetylornithine deacetylase; Validated; Region: PRK08596 698737001557 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698737001558 metal binding site [ion binding]; metal-binding site 698737001559 polyphosphate kinase; Provisional; Region: PRK05443 698737001560 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 698737001561 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 698737001562 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 698737001563 putative domain interface [polypeptide binding]; other site 698737001564 putative active site [active] 698737001565 catalytic site [active] 698737001566 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 698737001567 putative domain interface [polypeptide binding]; other site 698737001568 putative active site [active] 698737001569 catalytic site [active] 698737001570 exopolyphosphatase; Region: exo_poly_only; TIGR03706 698737001571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698737001572 nucleotide binding site [chemical binding]; other site 698737001573 AbgT putative transporter family; Region: ABG_transport; pfam03806 698737001574 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 698737001575 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 698737001576 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 698737001577 oligomer interface [polypeptide binding]; other site 698737001578 active site 698737001579 metal binding site [ion binding]; metal-binding site 698737001580 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 698737001581 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 698737001582 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698737001583 homodimer interface [polypeptide binding]; other site 698737001584 substrate-cofactor binding pocket; other site 698737001585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737001586 catalytic residue [active] 698737001587 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 698737001588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001589 dimer interface [polypeptide binding]; other site 698737001590 conserved gate region; other site 698737001591 ABC-ATPase subunit interface; other site 698737001592 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 698737001593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001594 dimer interface [polypeptide binding]; other site 698737001595 conserved gate region; other site 698737001596 ABC-ATPase subunit interface; other site 698737001597 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 698737001598 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 698737001599 Walker A/P-loop; other site 698737001600 ATP binding site [chemical binding]; other site 698737001601 Q-loop/lid; other site 698737001602 ABC transporter signature motif; other site 698737001603 Walker B; other site 698737001604 D-loop; other site 698737001605 H-loop/switch region; other site 698737001606 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 698737001607 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698737001608 membrane-bound complex binding site; other site 698737001609 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 698737001610 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 698737001611 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 698737001612 active site 698737001613 metal binding site [ion binding]; metal-binding site 698737001614 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698737001615 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 698737001616 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 698737001617 active site 698737001618 FMN binding site [chemical binding]; other site 698737001619 substrate binding site [chemical binding]; other site 698737001620 3Fe-4S cluster binding site [ion binding]; other site 698737001621 CAAX protease self-immunity; Region: Abi; pfam02517 698737001622 CAAX protease self-immunity; Region: Abi; pfam02517 698737001623 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 698737001624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737001625 Walker A/P-loop; other site 698737001626 ATP binding site [chemical binding]; other site 698737001627 Q-loop/lid; other site 698737001628 ABC transporter signature motif; other site 698737001629 Walker B; other site 698737001630 D-loop; other site 698737001631 H-loop/switch region; other site 698737001632 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 698737001633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737001634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737001635 dimer interface [polypeptide binding]; other site 698737001636 phosphorylation site [posttranslational modification] 698737001637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001638 ATP binding site [chemical binding]; other site 698737001639 Mg2+ binding site [ion binding]; other site 698737001640 G-X-G motif; other site 698737001641 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737001642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737001643 active site 698737001644 phosphorylation site [posttranslational modification] 698737001645 intermolecular recognition site; other site 698737001646 dimerization interface [polypeptide binding]; other site 698737001647 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737001648 DNA binding site [nucleotide binding] 698737001649 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698737001650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001651 putative substrate translocation pore; other site 698737001652 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698737001653 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698737001654 substrate binding pocket [chemical binding]; other site 698737001655 catalytic triad [active] 698737001656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 698737001657 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 698737001658 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 698737001659 potential frameshift: common BLAST hit: gi|224477817|ref|YP_002635423.1| alcohol dehydrogenase, zinc-containing 698737001660 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698737001661 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698737001662 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698737001663 putative NAD(P) binding site [chemical binding]; other site 698737001664 catalytic Zn binding site [ion binding]; other site 698737001665 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 698737001666 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698737001667 Walker A/P-loop; other site 698737001668 ATP binding site [chemical binding]; other site 698737001669 Q-loop/lid; other site 698737001670 ABC transporter signature motif; other site 698737001671 Walker B; other site 698737001672 D-loop; other site 698737001673 H-loop/switch region; other site 698737001674 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 698737001675 FOG: CBS domain [General function prediction only]; Region: COG0517 698737001676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001677 dimer interface [polypeptide binding]; other site 698737001678 conserved gate region; other site 698737001679 putative PBP binding loops; other site 698737001680 ABC-ATPase subunit interface; other site 698737001681 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 698737001682 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 698737001683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001684 dimer interface [polypeptide binding]; other site 698737001685 conserved gate region; other site 698737001686 ABC-ATPase subunit interface; other site 698737001687 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 698737001688 Protein of unknown function (DUF443); Region: DUF443; pfam04276 698737001689 Protein of unknown function (DUF443); Region: DUF443; pfam04276 698737001690 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 698737001691 Protein of unknown function (DUF443); Region: DUF443; pfam04276 698737001692 antiholin-like protein LrgB; Provisional; Region: PRK04288 698737001693 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 698737001694 two-component response regulator; Provisional; Region: PRK14084 698737001695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737001696 active site 698737001697 phosphorylation site [posttranslational modification] 698737001698 intermolecular recognition site; other site 698737001699 dimerization interface [polypeptide binding]; other site 698737001700 LytTr DNA-binding domain; Region: LytTR; pfam04397 698737001701 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 698737001702 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 698737001703 GAF domain; Region: GAF; cl17456 698737001704 Histidine kinase; Region: His_kinase; pfam06580 698737001705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001706 ATP binding site [chemical binding]; other site 698737001707 Mg2+ binding site [ion binding]; other site 698737001708 G-X-G motif; other site 698737001709 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737001710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001711 putative substrate translocation pore; other site 698737001712 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698737001713 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 698737001714 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698737001715 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 698737001716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737001717 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 698737001718 NAD(P) binding site [chemical binding]; other site 698737001719 active site 698737001720 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698737001721 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698737001722 Beta-lactamase; Region: Beta-lactamase; pfam00144 698737001723 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 698737001724 Amino acid permease; Region: AA_permease_2; pfam13520 698737001725 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698737001726 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698737001727 putative phosphoesterase; Region: acc_ester; TIGR03729 698737001728 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737001729 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 698737001730 putative active site [active] 698737001731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 698737001732 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 698737001733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001734 putative substrate translocation pore; other site 698737001735 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698737001736 Predicted membrane protein [Function unknown]; Region: COG2246 698737001737 GtrA-like protein; Region: GtrA; pfam04138 698737001738 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698737001739 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 698737001740 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737001741 catalytic core [active] 698737001742 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737001743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737001745 putative substrate translocation pore; other site 698737001746 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698737001747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698737001748 substrate binding pocket [chemical binding]; other site 698737001749 membrane-bound complex binding site; other site 698737001750 hinge residues; other site 698737001751 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698737001752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001753 dimer interface [polypeptide binding]; other site 698737001754 conserved gate region; other site 698737001755 putative PBP binding loops; other site 698737001756 ABC-ATPase subunit interface; other site 698737001757 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698737001758 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698737001759 Walker A/P-loop; other site 698737001760 ATP binding site [chemical binding]; other site 698737001761 Q-loop/lid; other site 698737001762 ABC transporter signature motif; other site 698737001763 Walker B; other site 698737001764 D-loop; other site 698737001765 H-loop/switch region; other site 698737001766 FemAB family; Region: FemAB; pfam02388 698737001767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 698737001768 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698737001769 Thioredoxin; Region: Thioredoxin_4; cl17273 698737001770 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 698737001771 putative hydrophobic ligand binding site [chemical binding]; other site 698737001772 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 698737001773 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698737001774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737001775 Walker A/P-loop; other site 698737001776 ATP binding site [chemical binding]; other site 698737001777 Q-loop/lid; other site 698737001778 ABC transporter signature motif; other site 698737001779 Walker B; other site 698737001780 D-loop; other site 698737001781 H-loop/switch region; other site 698737001782 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698737001783 putative active site [active] 698737001784 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 698737001785 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 698737001786 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 698737001787 putative active site [active] 698737001788 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 698737001789 active site 698737001790 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 698737001791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698737001792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737001793 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698737001794 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 698737001795 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698737001796 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 698737001797 [2Fe-2S] cluster binding site [ion binding]; other site 698737001798 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 698737001799 active site 698737001800 SAM binding site [chemical binding]; other site 698737001801 homodimer interface [polypeptide binding]; other site 698737001802 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698737001803 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698737001804 [4Fe-4S] binding site [ion binding]; other site 698737001805 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698737001806 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698737001807 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698737001808 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698737001809 molybdopterin cofactor binding site; other site 698737001810 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698737001811 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 698737001812 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 698737001813 potential frameshift: common BLAST hit: gi|269204025|ref|YP_003283294.1| NreA 698737001814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698737001815 Histidine kinase; Region: HisKA_3; pfam07730 698737001816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001817 ATP binding site [chemical binding]; other site 698737001818 Mg2+ binding site [ion binding]; other site 698737001819 G-X-G motif; other site 698737001820 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698737001821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737001822 active site 698737001823 phosphorylation site [posttranslational modification] 698737001824 intermolecular recognition site; other site 698737001825 dimerization interface [polypeptide binding]; other site 698737001826 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698737001827 DNA binding residues [nucleotide binding] 698737001828 dimerization interface [polypeptide binding]; other site 698737001829 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698737001830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001831 putative substrate translocation pore; other site 698737001832 MarR family; Region: MarR_2; cl17246 698737001833 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 698737001834 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698737001835 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 698737001836 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 698737001837 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698737001838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698737001839 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 698737001840 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 698737001841 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737001842 active site turn [active] 698737001843 phosphorylation site [posttranslational modification] 698737001844 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698737001845 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698737001846 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 698737001847 Cl binding site [ion binding]; other site 698737001848 oligomer interface [polypeptide binding]; other site 698737001849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737001850 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 698737001851 Predicted membrane protein [Function unknown]; Region: COG1511 698737001852 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698737001853 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698737001854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737001855 MarR family; Region: MarR_2; pfam12802 698737001856 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698737001857 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 698737001858 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698737001859 potential frameshift: common BLAST hit: gi|87162114|ref|YP_492795.1| ABC transporter ATP-binding protein 698737001860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737001861 ABC transporter signature motif; other site 698737001862 Walker B; other site 698737001863 D-loop; other site 698737001864 H-loop/switch region; other site 698737001865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 698737001866 Walker A/P-loop; other site 698737001867 ATP binding site [chemical binding]; other site 698737001868 Q-loop/lid; other site 698737001869 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698737001870 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698737001871 Walker A/P-loop; other site 698737001872 ATP binding site [chemical binding]; other site 698737001873 Q-loop/lid; other site 698737001874 ABC transporter signature motif; other site 698737001875 Walker B; other site 698737001876 D-loop; other site 698737001877 H-loop/switch region; other site 698737001878 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698737001879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001880 putative PBP binding loops; other site 698737001881 ABC-ATPase subunit interface; other site 698737001882 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698737001883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737001884 dimer interface [polypeptide binding]; other site 698737001885 conserved gate region; other site 698737001886 putative PBP binding loops; other site 698737001887 ABC-ATPase subunit interface; other site 698737001888 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 698737001889 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698737001890 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 698737001891 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698737001892 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 698737001893 UreF; Region: UreF; pfam01730 698737001894 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 698737001895 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 698737001896 dimer interface [polypeptide binding]; other site 698737001897 catalytic residues [active] 698737001898 urease subunit alpha; Reviewed; Region: ureC; PRK13207 698737001899 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 698737001900 subunit interactions [polypeptide binding]; other site 698737001901 active site 698737001902 flap region; other site 698737001903 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 698737001904 gamma-beta subunit interface [polypeptide binding]; other site 698737001905 alpha-beta subunit interface [polypeptide binding]; other site 698737001906 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 698737001907 alpha-gamma subunit interface [polypeptide binding]; other site 698737001908 beta-gamma subunit interface [polypeptide binding]; other site 698737001909 Urea transporter; Region: UT; cl01829 698737001910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737001911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737001912 myosin-cross-reactive antigen; Provisional; Region: PRK13977 698737001913 ThiC-associated domain; Region: ThiC-associated; pfam13667 698737001914 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698737001915 ThiC family; Region: ThiC; pfam01964 698737001916 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698737001917 tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218 698737001918 Integral membrane protein DUF95; Region: DUF95; pfam01944 698737001919 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698737001920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737001921 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737001922 ABC transporter; Region: ABC_tran_2; pfam12848 698737001923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737001924 Protein of unknown function (DUF443); Region: DUF443; pfam04276 698737001925 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698737001926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737001927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737001928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698737001929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698737001930 dimerization interface [polypeptide binding]; other site 698737001931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737001932 Coenzyme A binding pocket [chemical binding]; other site 698737001933 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737001934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737001935 non-specific DNA binding site [nucleotide binding]; other site 698737001936 salt bridge; other site 698737001937 sequence-specific DNA binding site [nucleotide binding]; other site 698737001938 CAAX protease self-immunity; Region: Abi; pfam02517 698737001939 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698737001940 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698737001941 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 698737001942 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 698737001943 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698737001944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737001945 S-adenosylmethionine binding site [chemical binding]; other site 698737001946 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 698737001947 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698737001948 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 698737001949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737001950 ATP binding site [chemical binding]; other site 698737001951 putative Mg++ binding site [ion binding]; other site 698737001952 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737001953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737001954 non-specific DNA binding site [nucleotide binding]; other site 698737001955 salt bridge; other site 698737001956 sequence-specific DNA binding site [nucleotide binding]; other site 698737001957 CAAX protease self-immunity; Region: Abi; pfam02517 698737001958 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737001959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737001960 sequence-specific DNA binding site [nucleotide binding]; other site 698737001961 salt bridge; other site 698737001962 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 698737001963 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 698737001964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698737001965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737001966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737001967 Coenzyme A binding pocket [chemical binding]; other site 698737001968 Poxvirus proteins of unknown function; Region: DUF230; cl17785 698737001969 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698737001970 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698737001971 NAD(P) binding site [chemical binding]; other site 698737001972 Imelysin; Region: Peptidase_M75; pfam09375 698737001973 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 698737001974 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 698737001975 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 698737001976 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 698737001977 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698737001978 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698737001979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737001980 Coenzyme A binding pocket [chemical binding]; other site 698737001981 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698737001982 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 698737001983 L-lactate permease; Region: Lactate_perm; cl00701 698737001984 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698737001985 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 698737001986 putative ADP-binding pocket [chemical binding]; other site 698737001987 malate:quinone oxidoreductase; Validated; Region: PRK05257 698737001988 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 698737001989 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 698737001990 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 698737001991 LytTr DNA-binding domain; Region: LytTR; smart00850 698737001992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737001993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698737001994 dimerization interface [polypeptide binding]; other site 698737001995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737001996 dimer interface [polypeptide binding]; other site 698737001997 phosphorylation site [posttranslational modification] 698737001998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737001999 ATP binding site [chemical binding]; other site 698737002000 Mg2+ binding site [ion binding]; other site 698737002001 G-X-G motif; other site 698737002002 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737002003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737002004 active site 698737002005 phosphorylation site [posttranslational modification] 698737002006 intermolecular recognition site; other site 698737002007 dimerization interface [polypeptide binding]; other site 698737002008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737002009 DNA binding site [nucleotide binding] 698737002010 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698737002011 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698737002012 FtsX-like permease family; Region: FtsX; pfam02687 698737002013 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698737002014 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737002015 Walker A/P-loop; other site 698737002016 ATP binding site [chemical binding]; other site 698737002017 Q-loop/lid; other site 698737002018 ABC transporter signature motif; other site 698737002019 Walker B; other site 698737002020 D-loop; other site 698737002021 H-loop/switch region; other site 698737002022 Uncharacterized conserved protein [Function unknown]; Region: COG1434 698737002023 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698737002024 putative active site [active] 698737002025 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737002026 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737002027 putative DNA binding site [nucleotide binding]; other site 698737002028 putative Zn2+ binding site [ion binding]; other site 698737002029 Predicted membrane protein [Function unknown]; Region: COG4640 698737002030 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 698737002031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002032 putative substrate translocation pore; other site 698737002033 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 698737002034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737002035 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 698737002036 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737002037 E3 interaction surface; other site 698737002038 lipoyl attachment site [posttranslational modification]; other site 698737002039 HlyD family secretion protein; Region: HlyD_3; pfam13437 698737002040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002041 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698737002042 putative substrate translocation pore; other site 698737002043 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 698737002044 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698737002045 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698737002046 active site 698737002047 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 698737002048 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 698737002049 oligomer interface [polypeptide binding]; other site 698737002050 metal binding site [ion binding]; metal-binding site 698737002051 metal binding site [ion binding]; metal-binding site 698737002052 putative Cl binding site [ion binding]; other site 698737002053 aspartate ring; other site 698737002054 basic sphincter; other site 698737002055 hydrophobic gate; other site 698737002056 periplasmic entrance; other site 698737002057 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 698737002058 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 698737002059 homotetramer interface [polypeptide binding]; other site 698737002060 FMN binding site [chemical binding]; other site 698737002061 homodimer contacts [polypeptide binding]; other site 698737002062 putative active site [active] 698737002063 putative substrate binding site [chemical binding]; other site 698737002064 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 698737002065 active site 698737002066 DNA binding site [nucleotide binding] 698737002067 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737002068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737002069 non-specific DNA binding site [nucleotide binding]; other site 698737002070 salt bridge; other site 698737002071 sequence-specific DNA binding site [nucleotide binding]; other site 698737002072 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698737002073 active site 698737002074 catalytic residues [active] 698737002075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 698737002076 MOSC domain; Region: MOSC; pfam03473 698737002077 3-alpha domain; Region: 3-alpha; pfam03475 698737002078 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 698737002079 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737002080 active site 698737002081 dimer interface [polypeptide binding]; other site 698737002082 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 698737002083 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698737002084 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698737002085 metal binding site [ion binding]; metal-binding site 698737002086 oxidoreductase; Provisional; Region: PRK07985 698737002087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737002088 NAD(P) binding site [chemical binding]; other site 698737002089 active site 698737002090 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 698737002091 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 698737002092 putative hydrophobic ligand binding site [chemical binding]; other site 698737002093 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698737002094 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698737002095 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698737002096 putative active site [active] 698737002097 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 698737002098 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698737002099 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737002100 active site turn [active] 698737002101 phosphorylation site [posttranslational modification] 698737002102 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 698737002103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737002104 active site 698737002105 motif I; other site 698737002106 motif II; other site 698737002107 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698737002108 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698737002109 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 698737002110 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 698737002111 putative active site [active] 698737002112 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 698737002113 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737002114 active site turn [active] 698737002115 phosphorylation site [posttranslational modification] 698737002116 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698737002117 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 698737002118 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 698737002119 putative active site [active] 698737002120 Uncharacterized conserved protein [Function unknown]; Region: COG3589 698737002121 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 698737002122 Predicted transcriptional regulator [Transcription]; Region: COG2378 698737002123 HTH domain; Region: HTH_11; pfam08279 698737002124 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698737002125 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698737002126 active site 698737002127 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 698737002128 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 698737002129 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 698737002130 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 698737002131 4Fe-4S binding domain; Region: Fer4_6; pfam12837 698737002132 4Fe-4S binding domain; Region: Fer4; pfam00037 698737002133 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 698737002134 [4Fe-4S] binding site [ion binding]; other site 698737002135 molybdopterin cofactor binding site; other site 698737002136 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 698737002137 molybdopterin cofactor binding site; other site 698737002138 Uncharacterized conserved protein [Function unknown]; Region: COG2427 698737002139 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 698737002140 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 698737002141 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698737002142 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 698737002143 putative ligand binding site [chemical binding]; other site 698737002144 putative NAD binding site [chemical binding]; other site 698737002145 catalytic site [active] 698737002146 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 698737002147 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 698737002148 CHAP domain; Region: CHAP; pfam05257 698737002149 Surface antigen [General function prediction only]; Region: COG3942 698737002150 Tic20-like protein; Region: Tic20; pfam09685 698737002151 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698737002152 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 698737002153 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 698737002154 Surface antigen [General function prediction only]; Region: COG3942 698737002155 CHAP domain; Region: CHAP; pfam05257 698737002156 potential frameshift: common BLAST hit: gi|27468789|ref|NP_765426.1| transcription regulator 698737002157 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 698737002158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698737002159 MarR family; Region: MarR_2; cl17246 698737002160 MarR family; Region: MarR_2; cl17246 698737002161 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 698737002162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737002163 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 698737002164 Walker A motif; other site 698737002165 ATP binding site [chemical binding]; other site 698737002166 Walker B motif; other site 698737002167 arginine finger; other site 698737002168 UvrB/uvrC motif; Region: UVR; pfam02151 698737002169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737002170 Walker A motif; other site 698737002171 ATP binding site [chemical binding]; other site 698737002172 Walker B motif; other site 698737002173 arginine finger; other site 698737002174 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698737002175 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 698737002176 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698737002177 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 698737002178 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698737002179 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737002180 intersubunit interface [polypeptide binding]; other site 698737002181 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 698737002182 active site 698737002183 dimerization interface [polypeptide binding]; other site 698737002184 BioY family; Region: BioY; pfam02632 698737002185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737002186 Coenzyme A binding pocket [chemical binding]; other site 698737002187 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 698737002188 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698737002189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698737002190 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 698737002191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737002192 dimer interface [polypeptide binding]; other site 698737002193 conserved gate region; other site 698737002194 putative PBP binding loops; other site 698737002195 ABC-ATPase subunit interface; other site 698737002196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737002197 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737002198 Walker A/P-loop; other site 698737002199 ATP binding site [chemical binding]; other site 698737002200 Q-loop/lid; other site 698737002201 ABC transporter signature motif; other site 698737002202 Walker B; other site 698737002203 D-loop; other site 698737002204 H-loop/switch region; other site 698737002205 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 698737002206 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698737002207 ATP binding site [chemical binding]; other site 698737002208 substrate interface [chemical binding]; other site 698737002209 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698737002210 MPT binding site; other site 698737002211 trimer interface [polypeptide binding]; other site 698737002212 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698737002213 trimer interface [polypeptide binding]; other site 698737002214 dimer interface [polypeptide binding]; other site 698737002215 putative active site [active] 698737002216 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698737002217 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698737002218 dimer interface [polypeptide binding]; other site 698737002219 putative functional site; other site 698737002220 putative MPT binding site; other site 698737002221 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698737002222 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698737002223 MoaE homodimer interface [polypeptide binding]; other site 698737002224 MoaD interaction [polypeptide binding]; other site 698737002225 active site residues [active] 698737002226 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 698737002227 MoaE interaction surface [polypeptide binding]; other site 698737002228 MoeB interaction surface [polypeptide binding]; other site 698737002229 thiocarboxylated glycine; other site 698737002230 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 698737002231 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698737002232 GTP binding site; other site 698737002233 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 698737002234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737002235 FeS/SAM binding site; other site 698737002236 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698737002237 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 698737002238 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698737002239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737002240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002241 putative substrate translocation pore; other site 698737002242 MarR family; Region: MarR_2; cl17246 698737002243 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737002244 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 698737002245 FemAB family; Region: FemAB; pfam02388 698737002246 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 698737002247 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 698737002248 Protein export membrane protein; Region: SecD_SecF; cl14618 698737002249 Predicted permeases [General function prediction only]; Region: COG0679 698737002250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737002251 Coenzyme A binding pocket [chemical binding]; other site 698737002252 DNA topoisomerase III; Provisional; Region: PRK07726 698737002253 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 698737002254 active site 698737002255 putative interdomain interaction site [polypeptide binding]; other site 698737002256 putative metal-binding site [ion binding]; other site 698737002257 putative nucleotide binding site [chemical binding]; other site 698737002258 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698737002259 domain I; other site 698737002260 DNA binding groove [nucleotide binding] 698737002261 phosphate binding site [ion binding]; other site 698737002262 domain II; other site 698737002263 domain III; other site 698737002264 nucleotide binding site [chemical binding]; other site 698737002265 catalytic site [active] 698737002266 domain IV; other site 698737002267 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 698737002268 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698737002269 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 698737002270 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 698737002271 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 698737002272 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 698737002273 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698737002274 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698737002275 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698737002276 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 698737002277 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698737002278 putative translocon binding site; other site 698737002279 protein-rRNA interface [nucleotide binding]; other site 698737002280 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698737002281 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698737002282 G-X-X-G motif; other site 698737002283 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698737002284 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698737002285 23S rRNA interface [nucleotide binding]; other site 698737002286 5S rRNA interface [nucleotide binding]; other site 698737002287 putative antibiotic binding site [chemical binding]; other site 698737002288 L25 interface [polypeptide binding]; other site 698737002289 L27 interface [polypeptide binding]; other site 698737002290 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698737002291 23S rRNA interface [nucleotide binding]; other site 698737002292 putative translocon interaction site; other site 698737002293 signal recognition particle (SRP54) interaction site; other site 698737002294 L23 interface [polypeptide binding]; other site 698737002295 trigger factor interaction site; other site 698737002296 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 698737002297 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 698737002298 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698737002299 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 698737002300 RNA binding site [nucleotide binding]; other site 698737002301 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698737002302 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698737002303 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698737002304 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 698737002305 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 698737002306 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698737002307 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698737002308 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698737002309 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698737002310 5S rRNA interface [nucleotide binding]; other site 698737002311 L27 interface [polypeptide binding]; other site 698737002312 23S rRNA interface [nucleotide binding]; other site 698737002313 L5 interface [polypeptide binding]; other site 698737002314 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 698737002315 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698737002316 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698737002317 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698737002318 23S rRNA binding site [nucleotide binding]; other site 698737002319 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 698737002320 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698737002321 SecY translocase; Region: SecY; pfam00344 698737002322 adenylate kinase; Reviewed; Region: adk; PRK00279 698737002323 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698737002324 AMP-binding site [chemical binding]; other site 698737002325 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698737002326 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698737002327 rRNA binding site [nucleotide binding]; other site 698737002328 predicted 30S ribosome binding site; other site 698737002329 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 698737002330 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 698737002331 30S ribosomal protein S13; Region: bact_S13; TIGR03631 698737002332 30S ribosomal protein S11; Validated; Region: PRK05309 698737002333 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698737002334 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698737002335 alphaNTD homodimer interface [polypeptide binding]; other site 698737002336 alphaNTD - beta interaction site [polypeptide binding]; other site 698737002337 alphaNTD - beta' interaction site [polypeptide binding]; other site 698737002338 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 698737002339 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 698737002340 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 698737002341 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698737002342 Walker A/P-loop; other site 698737002343 ATP binding site [chemical binding]; other site 698737002344 Q-loop/lid; other site 698737002345 ABC transporter signature motif; other site 698737002346 Walker B; other site 698737002347 D-loop; other site 698737002348 H-loop/switch region; other site 698737002349 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 698737002350 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698737002351 Walker A/P-loop; other site 698737002352 ATP binding site [chemical binding]; other site 698737002353 Q-loop/lid; other site 698737002354 ABC transporter signature motif; other site 698737002355 Walker B; other site 698737002356 D-loop; other site 698737002357 H-loop/switch region; other site 698737002358 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698737002359 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698737002360 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698737002361 dimerization interface 3.5A [polypeptide binding]; other site 698737002362 active site 698737002363 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698737002364 23S rRNA interface [nucleotide binding]; other site 698737002365 L3 interface [polypeptide binding]; other site 698737002366 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 698737002367 hypothetical protein; Provisional; Region: PRK06474 698737002368 dimerization interface [polypeptide binding]; other site 698737002369 putative DNA binding site [nucleotide binding]; other site 698737002370 putative Zn2+ binding site [ion binding]; other site 698737002371 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698737002372 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737002373 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698737002374 Walker A/P-loop; other site 698737002375 ATP binding site [chemical binding]; other site 698737002376 Q-loop/lid; other site 698737002377 ABC transporter signature motif; other site 698737002378 Walker B; other site 698737002379 D-loop; other site 698737002380 H-loop/switch region; other site 698737002381 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 698737002382 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 698737002383 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698737002384 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698737002385 Walker A/P-loop; other site 698737002386 ATP binding site [chemical binding]; other site 698737002387 Q-loop/lid; other site 698737002388 ABC transporter signature motif; other site 698737002389 Walker B; other site 698737002390 D-loop; other site 698737002391 H-loop/switch region; other site 698737002392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737002393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 698737002394 Condensation domain; Region: Condensation; pfam00668 698737002395 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 698737002396 AMP-binding enzyme; Region: AMP-binding; pfam00501 698737002397 acyl-activating enzyme (AAE) consensus motif; other site 698737002398 AMP binding site [chemical binding]; other site 698737002399 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737002400 Condensation domain; Region: Condensation; pfam00668 698737002401 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 698737002402 Condensation domain; Region: Condensation; pfam00668 698737002403 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737002404 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698737002405 acyl-activating enzyme (AAE) consensus motif; other site 698737002406 AMP binding site [chemical binding]; other site 698737002407 active site 698737002408 CoA binding site [chemical binding]; other site 698737002409 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737002410 Condensation domain; Region: Condensation; pfam00668 698737002411 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698737002412 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 698737002413 acyl-activating enzyme (AAE) consensus motif; other site 698737002414 active site 698737002415 AMP binding site [chemical binding]; other site 698737002416 CoA binding site [chemical binding]; other site 698737002417 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698737002418 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737002419 Condensation domain; Region: Condensation; pfam00668 698737002420 Condensation domain; Region: Condensation; pfam00668 698737002421 AMP-binding enzyme; Region: AMP-binding; pfam00501 698737002422 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698737002423 acyl-activating enzyme (AAE) consensus motif; other site 698737002424 AMP binding site [chemical binding]; other site 698737002425 active site 698737002426 CoA binding site [chemical binding]; other site 698737002427 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737002428 Condensation domain; Region: Condensation; pfam00668 698737002429 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737002430 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 698737002431 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737002432 Condensation domain; Region: Condensation; pfam00668 698737002433 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737002434 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737002435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737002436 NAD(P) binding site [chemical binding]; other site 698737002437 active site 698737002438 Thioesterase domain; Region: Thioesterase; pfam00975 698737002439 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698737002440 AMP-binding enzyme; Region: AMP-binding; pfam00501 698737002441 acyl-activating enzyme (AAE) consensus motif; other site 698737002442 AMP binding site [chemical binding]; other site 698737002443 active site 698737002444 CoA binding site [chemical binding]; other site 698737002445 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737002446 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 698737002447 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698737002448 Uncharacterized conserved protein [Function unknown]; Region: COG1359 698737002449 NAD-dependent deacetylase; Provisional; Region: PRK00481 698737002450 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 698737002451 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698737002452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737002453 DNA-binding site [nucleotide binding]; DNA binding site 698737002454 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698737002455 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 698737002456 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 698737002457 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698737002458 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 698737002459 putative substrate binding site [chemical binding]; other site 698737002460 putative ATP binding site [chemical binding]; other site 698737002461 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 698737002462 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 698737002463 methionine cluster; other site 698737002464 active site 698737002465 phosphorylation site [posttranslational modification] 698737002466 metal binding site [ion binding]; metal-binding site 698737002467 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 698737002468 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 698737002469 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 698737002470 active site 698737002471 P-loop; other site 698737002472 phosphorylation site [posttranslational modification] 698737002473 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 698737002474 beta-galactosidase; Region: BGL; TIGR03356 698737002475 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 698737002476 Prostaglandin dehydrogenases; Region: PGDH; cd05288 698737002477 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 698737002478 NAD(P) binding site [chemical binding]; other site 698737002479 substrate binding site [chemical binding]; other site 698737002480 dimer interface [polypeptide binding]; other site 698737002481 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 698737002482 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 698737002483 putative NAD(P) binding site [chemical binding]; other site 698737002484 dimer interface [polypeptide binding]; other site 698737002485 Small integral membrane protein [Function unknown]; Region: COG5547 698737002486 Asp23 family; Region: Asp23; pfam03780 698737002487 IucA / IucC family; Region: IucA_IucC; pfam04183 698737002488 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698737002489 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 698737002490 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 698737002491 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737002492 catalytic residue [active] 698737002493 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 698737002494 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698737002495 siderophore binding site; other site 698737002496 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698737002497 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737002498 ABC-ATPase subunit interface; other site 698737002499 dimer interface [polypeptide binding]; other site 698737002500 putative PBP binding regions; other site 698737002501 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698737002502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737002503 ABC-ATPase subunit interface; other site 698737002504 dimer interface [polypeptide binding]; other site 698737002505 putative PBP binding regions; other site 698737002506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 698737002507 Nucleoside recognition; Region: Gate; pfam07670 698737002508 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 698737002509 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 698737002510 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 698737002511 substrate binding site; other site 698737002512 dimerization interface; other site 698737002513 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 698737002514 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 698737002515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737002517 putative substrate translocation pore; other site 698737002518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737002520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737002521 putative substrate translocation pore; other site 698737002522 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 698737002523 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698737002524 Walker A motif; other site 698737002525 TIGR00159 family protein; Region: TIGR00159 698737002526 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 698737002527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 698737002528 YbbR-like protein; Region: YbbR; pfam07949 698737002529 YbbR-like protein; Region: YbbR; pfam07949 698737002530 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 698737002531 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698737002532 active site 698737002533 substrate binding site [chemical binding]; other site 698737002534 metal binding site [ion binding]; metal-binding site 698737002535 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698737002536 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698737002537 glutaminase active site [active] 698737002538 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698737002539 dimer interface [polypeptide binding]; other site 698737002540 active site 698737002541 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698737002542 dimer interface [polypeptide binding]; other site 698737002543 active site 698737002544 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 698737002545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737002546 active site 698737002547 motif I; other site 698737002548 motif II; other site 698737002549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737002550 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 698737002551 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737002552 active site 698737002553 metal binding site [ion binding]; metal-binding site 698737002554 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698737002555 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698737002556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737002557 dimerization interface [polypeptide binding]; other site 698737002558 putative DNA binding site [nucleotide binding]; other site 698737002559 putative Zn2+ binding site [ion binding]; other site 698737002560 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 698737002561 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698737002562 NAD(P) binding site [chemical binding]; other site 698737002563 putative active site [active] 698737002564 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 698737002565 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 698737002566 EVE domain; Region: EVE; cl00728 698737002567 Protein of unknown function, DUF393; Region: DUF393; cl01136 698737002568 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698737002569 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698737002570 dimerization interface [polypeptide binding]; other site 698737002571 DPS ferroxidase diiron center [ion binding]; other site 698737002572 ion pore; other site 698737002573 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 698737002574 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 698737002575 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698737002576 intersubunit interface [polypeptide binding]; other site 698737002577 active site 698737002578 catalytic residue [active] 698737002579 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 698737002580 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698737002581 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698737002582 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 698737002583 phosphopentomutase; Provisional; Region: PRK05362 698737002584 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 698737002585 Predicted membrane protein [Function unknown]; Region: COG4270 698737002586 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 698737002587 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 698737002588 G1 box; other site 698737002589 GTP/Mg2+ binding site [chemical binding]; other site 698737002590 Switch I region; other site 698737002591 G2 box; other site 698737002592 G3 box; other site 698737002593 Switch II region; other site 698737002594 G4 box; other site 698737002595 G5 box; other site 698737002596 Nucleoside recognition; Region: Gate; pfam07670 698737002597 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 698737002598 Nucleoside recognition; Region: Gate; pfam07670 698737002599 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 698737002600 Helix-turn-helix domain; Region: HTH_28; pfam13518 698737002601 Homeodomain-like domain; Region: HTH_32; pfam13565 698737002602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698737002603 Integrase core domain; Region: rve; pfam00665 698737002604 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 698737002605 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698737002606 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698737002607 catalytic residues [active] 698737002608 catalytic nucleophile [active] 698737002609 Presynaptic Site I dimer interface [polypeptide binding]; other site 698737002610 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698737002611 Synaptic Flat tetramer interface [polypeptide binding]; other site 698737002612 Synaptic Site I dimer interface [polypeptide binding]; other site 698737002613 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698737002614 DNA-binding interface [nucleotide binding]; DNA binding site 698737002615 Predicted transcriptional regulator [Transcription]; Region: COG3682 698737002616 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 698737002617 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 698737002618 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 698737002619 beta-lactamase TEM; Provisional; Region: PRK15442 698737002620 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 698737002621 S-ribosylhomocysteinase; Provisional; Region: PRK02260 698737002622 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698737002623 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 698737002624 metal binding site [ion binding]; metal-binding site 698737002625 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698737002626 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 698737002627 pantothenate kinase; Provisional; Region: PRK13317 698737002628 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 698737002629 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698737002630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737002631 Coenzyme A binding pocket [chemical binding]; other site 698737002632 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 698737002633 CTP synthetase; Validated; Region: pyrG; PRK05380 698737002634 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 698737002635 Catalytic site [active] 698737002636 active site 698737002637 UTP binding site [chemical binding]; other site 698737002638 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 698737002639 active site 698737002640 putative oxyanion hole; other site 698737002641 catalytic triad [active] 698737002642 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 698737002643 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698737002644 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 698737002645 intersubunit interface [polypeptide binding]; other site 698737002646 active site 698737002647 zinc binding site [ion binding]; other site 698737002648 Na+ binding site [ion binding]; other site 698737002649 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698737002650 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698737002651 hinge; other site 698737002652 active site 698737002653 Predicted transcriptional regulators [Transcription]; Region: COG1733 698737002654 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 698737002655 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 698737002656 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698737002657 NAD binding site [chemical binding]; other site 698737002658 catalytic residues [active] 698737002659 transcription termination factor Rho; Provisional; Region: rho; PRK09376 698737002660 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 698737002661 RNA binding site [nucleotide binding]; other site 698737002662 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698737002663 multimer interface [polypeptide binding]; other site 698737002664 Walker A motif; other site 698737002665 ATP binding site [chemical binding]; other site 698737002666 Walker B motif; other site 698737002667 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 698737002668 thymidine kinase; Provisional; Region: PRK04296 698737002669 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698737002670 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698737002671 RF-1 domain; Region: RF-1; pfam00472 698737002672 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 698737002673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737002674 S-adenosylmethionine binding site [chemical binding]; other site 698737002675 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 698737002676 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 698737002677 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698737002678 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698737002679 active site 698737002680 hypothetical protein; Provisional; Region: PRK13690 698737002681 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698737002682 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698737002683 dimer interface [polypeptide binding]; other site 698737002684 active site 698737002685 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698737002686 folate binding site [chemical binding]; other site 698737002687 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737002688 active site 698737002689 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 698737002690 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 698737002691 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 698737002692 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 698737002693 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698737002694 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 698737002695 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698737002696 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698737002697 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698737002698 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698737002699 beta subunit interaction interface [polypeptide binding]; other site 698737002700 Walker A motif; other site 698737002701 ATP binding site [chemical binding]; other site 698737002702 Walker B motif; other site 698737002703 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698737002704 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 698737002705 core domain interface [polypeptide binding]; other site 698737002706 delta subunit interface [polypeptide binding]; other site 698737002707 epsilon subunit interface [polypeptide binding]; other site 698737002708 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698737002709 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 698737002710 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698737002711 alpha subunit interaction interface [polypeptide binding]; other site 698737002712 Walker A motif; other site 698737002713 ATP binding site [chemical binding]; other site 698737002714 Walker B motif; other site 698737002715 inhibitor binding site; inhibition site 698737002716 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698737002717 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698737002718 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 698737002719 gamma subunit interface [polypeptide binding]; other site 698737002720 epsilon subunit interface [polypeptide binding]; other site 698737002721 LBP interface [polypeptide binding]; other site 698737002722 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 698737002723 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698737002724 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698737002725 hinge; other site 698737002726 active site 698737002727 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 698737002728 YwpF-like protein; Region: YwpF; pfam14183 698737002729 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698737002730 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698737002731 dimer interface [polypeptide binding]; other site 698737002732 ssDNA binding site [nucleotide binding]; other site 698737002733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737002734 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 698737002735 N-acetyl-D-glucosamine binding site [chemical binding]; other site 698737002736 catalytic residue [active] 698737002737 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 698737002738 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698737002739 dimer interface [polypeptide binding]; other site 698737002740 substrate binding site [chemical binding]; other site 698737002741 ATP binding site [chemical binding]; other site 698737002742 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 698737002743 substrate binding site [chemical binding]; other site 698737002744 multimerization interface [polypeptide binding]; other site 698737002745 ATP binding site [chemical binding]; other site 698737002746 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698737002747 thiamine phosphate binding site [chemical binding]; other site 698737002748 active site 698737002749 pyrophosphate binding site [ion binding]; other site 698737002750 OxaA-like protein precursor; Provisional; Region: PRK02463 698737002751 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698737002752 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 698737002753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737002754 Zn2+ binding site [ion binding]; other site 698737002755 Mg2+ binding site [ion binding]; other site 698737002756 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 698737002757 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698737002758 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 698737002759 putative active site [active] 698737002760 catalytic site [active] 698737002761 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 698737002762 putative active site [active] 698737002763 catalytic site [active] 698737002764 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 698737002765 putative homodimer interface [polypeptide binding]; other site 698737002766 putative homotetramer interface [polypeptide binding]; other site 698737002767 allosteric switch controlling residues; other site 698737002768 putative metal binding site [ion binding]; other site 698737002769 putative homodimer-homodimer interface [polypeptide binding]; other site 698737002770 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 698737002771 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 698737002772 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698737002773 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698737002774 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 698737002775 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 698737002776 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698737002777 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737002778 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737002779 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698737002780 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698737002781 ATP binding site [chemical binding]; other site 698737002782 Mg++ binding site [ion binding]; other site 698737002783 motif III; other site 698737002784 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737002785 nucleotide binding region [chemical binding]; other site 698737002786 ATP-binding site [chemical binding]; other site 698737002787 Bacterial PH domain; Region: DUF304; cl01348 698737002788 Predicted membrane protein [Function unknown]; Region: COG3428 698737002789 Bacterial PH domain; Region: DUF304; pfam03703 698737002790 Bacterial PH domain; Region: DUF304; pfam03703 698737002791 Uncharacterized conserved protein [Function unknown]; Region: COG3402 698737002792 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 698737002793 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 698737002794 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698737002795 active site 698737002796 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737002797 dimer interface [polypeptide binding]; other site 698737002798 substrate binding site [chemical binding]; other site 698737002799 catalytic residues [active] 698737002800 PemK-like protein; Region: PemK; pfam02452 698737002801 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 698737002802 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 698737002803 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 698737002804 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 698737002805 anti sigma factor interaction site; other site 698737002806 regulatory phosphorylation site [posttranslational modification]; other site 698737002807 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 698737002808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737002809 ATP binding site [chemical binding]; other site 698737002810 Mg2+ binding site [ion binding]; other site 698737002811 G-X-G motif; other site 698737002812 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 698737002813 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698737002814 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698737002815 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698737002816 DNA binding residues [nucleotide binding] 698737002817 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698737002818 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698737002819 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 698737002820 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 698737002821 RNA binding site [nucleotide binding]; other site 698737002822 hypothetical protein; Provisional; Region: PRK04351 698737002823 SprT homologues; Region: SprT; cl01182 698737002824 LysE type translocator; Region: LysE; cl00565 698737002825 threonine dehydratase; Validated; Region: PRK08639 698737002826 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698737002827 tetramer interface [polypeptide binding]; other site 698737002828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737002829 catalytic residue [active] 698737002830 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698737002831 putative Ile/Val binding site [chemical binding]; other site 698737002832 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 698737002833 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698737002834 substrate binding site [chemical binding]; other site 698737002835 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698737002836 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698737002837 substrate binding site [chemical binding]; other site 698737002838 ligand binding site [chemical binding]; other site 698737002839 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 698737002840 tartrate dehydrogenase; Region: TTC; TIGR02089 698737002841 2-isopropylmalate synthase; Validated; Region: PRK00915 698737002842 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 698737002843 active site 698737002844 catalytic residues [active] 698737002845 metal binding site [ion binding]; metal-binding site 698737002846 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 698737002847 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698737002848 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 698737002849 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698737002850 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 698737002851 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 698737002852 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698737002853 PYR/PP interface [polypeptide binding]; other site 698737002854 dimer interface [polypeptide binding]; other site 698737002855 TPP binding site [chemical binding]; other site 698737002856 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 698737002857 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698737002858 TPP-binding site [chemical binding]; other site 698737002859 dimer interface [polypeptide binding]; other site 698737002860 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 698737002861 6-phosphogluconate dehydratase; Region: edd; TIGR01196 698737002862 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 698737002863 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 698737002864 Glycoprotease family; Region: Peptidase_M22; pfam00814 698737002865 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 698737002866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737002867 Coenzyme A binding pocket [chemical binding]; other site 698737002868 UGMP family protein; Validated; Region: PRK09604 698737002869 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 698737002870 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 698737002871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737002872 Walker A/P-loop; other site 698737002873 ATP binding site [chemical binding]; other site 698737002874 Q-loop/lid; other site 698737002875 ABC transporter signature motif; other site 698737002876 Walker B; other site 698737002877 D-loop; other site 698737002878 H-loop/switch region; other site 698737002879 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698737002880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737002881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737002882 ABC transporter; Region: ABC_tran_2; pfam12848 698737002883 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737002884 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 698737002885 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 698737002886 CoA binding domain; Region: CoA_binding; pfam02629 698737002887 Predicted transporter component [General function prediction only]; Region: COG2391 698737002888 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 698737002889 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 698737002890 CPxP motif; other site 698737002891 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 698737002892 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698737002893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698737002894 DNA binding site [nucleotide binding] 698737002895 domain linker motif; other site 698737002896 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698737002897 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 698737002898 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 698737002899 substrate binding [chemical binding]; other site 698737002900 active site 698737002901 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698737002902 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698737002903 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 698737002904 putative substrate binding site [chemical binding]; other site 698737002905 putative ATP binding site [chemical binding]; other site 698737002906 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 698737002907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737002908 active site 698737002909 phosphorylation site [posttranslational modification] 698737002910 intermolecular recognition site; other site 698737002911 dimerization interface [polypeptide binding]; other site 698737002912 LytTr DNA-binding domain; Region: LytTR; pfam04397 698737002913 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 698737002914 ATP binding site [chemical binding]; other site 698737002915 Mg2+ binding site [ion binding]; other site 698737002916 G-X-G motif; other site 698737002917 Staphylococcal AgrD protein; Region: AgrD; pfam05931 698737002918 Accessory gene regulator B; Region: AgrB; smart00793 698737002919 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698737002920 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 698737002921 putative active site [active] 698737002922 catalytic triad [active] 698737002923 putative dimer interface [polypeptide binding]; other site 698737002924 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 698737002925 dimer interface [polypeptide binding]; other site 698737002926 FMN binding site [chemical binding]; other site 698737002927 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 698737002928 CAAX protease self-immunity; Region: Abi; pfam02517 698737002929 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698737002930 oligomerisation interface [polypeptide binding]; other site 698737002931 mobile loop; other site 698737002932 roof hairpin; other site 698737002933 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698737002934 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698737002935 ring oligomerisation interface [polypeptide binding]; other site 698737002936 ATP/Mg binding site [chemical binding]; other site 698737002937 stacking interactions; other site 698737002938 hinge regions; other site 698737002939 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 698737002940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737002941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737002942 homodimer interface [polypeptide binding]; other site 698737002943 catalytic residue [active] 698737002944 Predicted transcriptional regulators [Transcription]; Region: COG1725 698737002945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737002946 DNA-binding site [nucleotide binding]; DNA binding site 698737002947 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737002948 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698737002949 Walker A/P-loop; other site 698737002950 ATP binding site [chemical binding]; other site 698737002951 Q-loop/lid; other site 698737002952 ABC transporter signature motif; other site 698737002953 Walker B; other site 698737002954 D-loop; other site 698737002955 H-loop/switch region; other site 698737002956 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 698737002957 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737002958 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698737002959 Walker A/P-loop; other site 698737002960 ATP binding site [chemical binding]; other site 698737002961 Q-loop/lid; other site 698737002962 ABC transporter signature motif; other site 698737002963 Walker B; other site 698737002964 D-loop; other site 698737002965 H-loop/switch region; other site 698737002966 KIF-1 binding protein C terminal; Region: KBP_C; pfam12309 698737002967 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737002968 catalytic residues [active] 698737002969 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 698737002970 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 698737002971 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 698737002972 active site 698737002973 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 698737002974 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 698737002975 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 698737002976 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 698737002977 NAD(P) binding site [chemical binding]; other site 698737002978 catalytic residues [active] 698737002979 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 698737002980 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 698737002981 DHHA2 domain; Region: DHHA2; pfam02833 698737002982 Isochorismatase family; Region: Isochorismatase; pfam00857 698737002983 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 698737002984 catalytic triad [active] 698737002985 conserved cis-peptide bond; other site 698737002986 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 698737002987 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698737002988 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698737002989 transmembrane helices; other site 698737002990 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 698737002991 Prephenate dehydratase; Region: PDT; pfam00800 698737002992 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698737002993 putative L-Phe binding site [chemical binding]; other site 698737002994 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 698737002995 active site 698737002996 dimer interface [polypeptide binding]; other site 698737002997 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698737002998 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698737002999 active site 698737003000 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698737003001 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698737003002 homodimer interface [polypeptide binding]; other site 698737003003 NAD binding pocket [chemical binding]; other site 698737003004 ATP binding pocket [chemical binding]; other site 698737003005 Mg binding site [ion binding]; other site 698737003006 active-site loop [active] 698737003007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 698737003008 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 698737003009 NETI protein; Region: NETI; pfam14044 698737003010 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 698737003011 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 698737003012 tetramer interface [polypeptide binding]; other site 698737003013 active site 698737003014 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 698737003015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 698737003016 PcrB family; Region: PcrB; pfam01884 698737003017 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 698737003018 substrate binding site [chemical binding]; other site 698737003019 putative active site [active] 698737003020 dimer interface [polypeptide binding]; other site 698737003021 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698737003022 Part of AAA domain; Region: AAA_19; pfam13245 698737003023 Family description; Region: UvrD_C_2; pfam13538 698737003024 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698737003025 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698737003026 nucleotide binding pocket [chemical binding]; other site 698737003027 K-X-D-G motif; other site 698737003028 catalytic site [active] 698737003029 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698737003030 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698737003031 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698737003032 Dimer interface [polypeptide binding]; other site 698737003033 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 698737003034 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 698737003035 putative dimer interface [polypeptide binding]; other site 698737003036 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 698737003037 putative dimer interface [polypeptide binding]; other site 698737003038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737003039 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698737003040 active site 698737003041 metal binding site [ion binding]; metal-binding site 698737003042 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698737003043 Na binding site [ion binding]; other site 698737003044 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 698737003045 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698737003046 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 698737003047 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698737003048 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698737003049 GatB domain; Region: GatB_Yqey; pfam02637 698737003050 putative lipid kinase; Reviewed; Region: PRK13337 698737003051 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698737003052 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698737003053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737003054 S-adenosylmethionine binding site [chemical binding]; other site 698737003055 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 698737003056 TfoX N-terminal domain; Region: TfoX_N; pfam04993 698737003057 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698737003058 active site 698737003059 DNA polymerase IV; Validated; Region: PRK02406 698737003060 DNA binding site [nucleotide binding] 698737003061 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698737003062 active site 698737003063 catalytic site [active] 698737003064 substrate binding site [chemical binding]; other site 698737003065 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698737003066 Ferritin-like domain; Region: Ferritin; pfam00210 698737003067 ferroxidase diiron center [ion binding]; other site 698737003068 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 698737003069 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737003070 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698737003071 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698737003072 catalytic triad [active] 698737003073 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 698737003074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737003075 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737003076 Predicted membrane protein [Function unknown]; Region: COG4129 698737003077 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 698737003078 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698737003079 active site 698737003080 Predicted membrane protein [Function unknown]; Region: COG4758 698737003081 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 698737003082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698737003083 Histidine kinase; Region: HisKA_3; pfam07730 698737003084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737003085 ATP binding site [chemical binding]; other site 698737003086 Mg2+ binding site [ion binding]; other site 698737003087 G-X-G motif; other site 698737003088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698737003089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737003090 active site 698737003091 phosphorylation site [posttranslational modification] 698737003092 intermolecular recognition site; other site 698737003093 dimerization interface [polypeptide binding]; other site 698737003094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698737003095 DNA binding residues [nucleotide binding] 698737003096 dimerization interface [polypeptide binding]; other site 698737003097 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 698737003098 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 698737003099 Low molecular weight phosphatase family; Region: LMWPc; cd00115 698737003100 active site 698737003101 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 698737003102 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 698737003103 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 698737003104 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 698737003105 Radical SAM superfamily; Region: Radical_SAM; pfam04055 698737003106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737003107 FeS/SAM binding site; other site 698737003108 YfkB-like domain; Region: YfkB; pfam08756 698737003109 intracellular protease, PfpI family; Region: PfpI; TIGR01382 698737003110 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 698737003111 proposed catalytic triad [active] 698737003112 conserved cys residue [active] 698737003113 glycosyltransferase; Provisional; Region: PRK13481 698737003114 Transglycosylase; Region: Transgly; pfam00912 698737003115 recombination regulator RecX; Provisional; Region: recX; PRK14135 698737003116 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 698737003117 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698737003118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737003119 Walker A/P-loop; other site 698737003120 ATP binding site [chemical binding]; other site 698737003121 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698737003122 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 698737003123 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 698737003124 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698737003125 minor groove reading motif; other site 698737003126 helix-hairpin-helix signature motif; other site 698737003127 substrate binding pocket [chemical binding]; other site 698737003128 active site 698737003129 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 698737003130 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 698737003131 DNA binding and oxoG recognition site [nucleotide binding] 698737003132 hypothetical protein; Provisional; Region: PRK13662 698737003133 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737003134 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698737003135 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 698737003136 Walker A/P-loop; other site 698737003137 ATP binding site [chemical binding]; other site 698737003138 Q-loop/lid; other site 698737003139 ABC transporter signature motif; other site 698737003140 Walker B; other site 698737003141 D-loop; other site 698737003142 H-loop/switch region; other site 698737003143 Predicted membrane protein [Function unknown]; Region: COG4129 698737003144 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 698737003145 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 698737003146 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698737003147 inhibitor-cofactor binding pocket; inhibition site 698737003148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737003149 catalytic residue [active] 698737003150 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698737003151 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698737003152 catalytic triad [active] 698737003153 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 698737003154 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698737003155 putative ligand binding site [chemical binding]; other site 698737003156 NAD binding site [chemical binding]; other site 698737003157 catalytic site [active] 698737003158 ferric uptake regulator; Provisional; Region: fur; PRK09462 698737003159 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698737003160 metal binding site 2 [ion binding]; metal-binding site 698737003161 putative DNA binding helix; other site 698737003162 metal binding site 1 [ion binding]; metal-binding site 698737003163 dimer interface [polypeptide binding]; other site 698737003164 structural Zn2+ binding site [ion binding]; other site 698737003165 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 698737003166 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 698737003167 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698737003168 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698737003169 substrate binding pocket [chemical binding]; other site 698737003170 membrane-bound complex binding site; other site 698737003171 hinge residues; other site 698737003172 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698737003173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737003174 dimer interface [polypeptide binding]; other site 698737003175 conserved gate region; other site 698737003176 putative PBP binding loops; other site 698737003177 ABC-ATPase subunit interface; other site 698737003178 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698737003179 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 698737003180 Walker A/P-loop; other site 698737003181 ATP binding site [chemical binding]; other site 698737003182 Q-loop/lid; other site 698737003183 ABC transporter signature motif; other site 698737003184 Walker B; other site 698737003185 D-loop; other site 698737003186 H-loop/switch region; other site 698737003187 epoxyqueuosine reductase; Region: TIGR00276 698737003188 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 698737003189 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 698737003190 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 698737003191 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 698737003192 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698737003193 Class II fumarases; Region: Fumarase_classII; cd01362 698737003194 active site 698737003195 tetramer interface [polypeptide binding]; other site 698737003196 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698737003197 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698737003198 active site 698737003199 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 698737003200 GAF domain; Region: GAF; pfam01590 698737003201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698737003202 Histidine kinase; Region: HisKA_3; pfam07730 698737003203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737003204 ATP binding site [chemical binding]; other site 698737003205 Mg2+ binding site [ion binding]; other site 698737003206 G-X-G motif; other site 698737003207 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698737003208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737003209 active site 698737003210 phosphorylation site [posttranslational modification] 698737003211 intermolecular recognition site; other site 698737003212 dimerization interface [polypeptide binding]; other site 698737003213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698737003214 DNA binding residues [nucleotide binding] 698737003215 dimerization interface [polypeptide binding]; other site 698737003216 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737003217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737003218 non-specific DNA binding site [nucleotide binding]; other site 698737003219 salt bridge; other site 698737003220 sequence-specific DNA binding site [nucleotide binding]; other site 698737003221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 698737003222 hypothetical protein; Provisional; Region: PRK13676 698737003223 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698737003224 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698737003225 active site 698737003226 metal binding site [ion binding]; metal-binding site 698737003227 DNA binding site [nucleotide binding] 698737003228 Uncharacterized conserved protein [Function unknown]; Region: COG4717 698737003229 P-loop containing region of AAA domain; Region: AAA_29; cl17516 698737003230 SdpI/YhfL protein family; Region: SdpI; pfam13630 698737003231 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 698737003232 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 698737003233 generic binding surface II; other site 698737003234 generic binding surface I; other site 698737003235 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737003236 Zn2+ binding site [ion binding]; other site 698737003237 Mg2+ binding site [ion binding]; other site 698737003238 Amidohydrolase; Region: Amidohydro_2; pfam04909 698737003239 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 698737003240 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 698737003241 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 698737003242 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 698737003243 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 698737003244 HIT family signature motif; other site 698737003245 catalytic residue [active] 698737003246 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698737003247 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698737003248 Walker A/P-loop; other site 698737003249 ATP binding site [chemical binding]; other site 698737003250 Q-loop/lid; other site 698737003251 ABC transporter signature motif; other site 698737003252 Walker B; other site 698737003253 D-loop; other site 698737003254 H-loop/switch region; other site 698737003255 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 698737003256 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698737003257 substrate binding site [chemical binding]; other site 698737003258 active site 698737003259 ferrochelatase; Provisional; Region: PRK12435 698737003260 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698737003261 C-terminal domain interface [polypeptide binding]; other site 698737003262 active site 698737003263 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698737003264 active site 698737003265 N-terminal domain interface [polypeptide binding]; other site 698737003266 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698737003267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698737003268 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 698737003269 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698737003270 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 698737003271 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 698737003272 acyl-activating enzyme (AAE) consensus motif; other site 698737003273 putative AMP binding site [chemical binding]; other site 698737003274 putative active site [active] 698737003275 putative CoA binding site [chemical binding]; other site 698737003276 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 698737003277 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 698737003278 metal binding site [ion binding]; metal-binding site 698737003279 substrate binding pocket [chemical binding]; other site 698737003280 hypothetical protein; Validated; Region: PRK00041 698737003281 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 698737003282 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 698737003283 nudix motif; other site 698737003284 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 698737003285 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698737003286 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 698737003287 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 698737003288 active site 698737003289 substrate-binding site [chemical binding]; other site 698737003290 metal-binding site [ion binding] 698737003291 ATP binding site [chemical binding]; other site 698737003292 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698737003293 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698737003294 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698737003295 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698737003296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698737003297 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698737003298 active site 698737003299 catalytic tetrad [active] 698737003300 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 698737003301 camphor resistance protein CrcB; Provisional; Region: PRK14201 698737003302 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 698737003303 active site 698737003304 intersubunit interactions; other site 698737003305 catalytic residue [active] 698737003306 RNA polymerase factor sigma-70; Validated; Region: PRK06759 698737003307 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 698737003308 DNA binding residues [nucleotide binding] 698737003309 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 698737003310 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 698737003311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 698737003312 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 698737003313 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 698737003314 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698737003315 catalytic motif [active] 698737003316 Zn binding site [ion binding]; other site 698737003317 RibD C-terminal domain; Region: RibD_C; cl17279 698737003318 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698737003319 Lumazine binding domain; Region: Lum_binding; pfam00677 698737003320 Lumazine binding domain; Region: Lum_binding; pfam00677 698737003321 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698737003322 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 698737003323 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698737003324 dimerization interface [polypeptide binding]; other site 698737003325 active site 698737003326 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698737003327 homopentamer interface [polypeptide binding]; other site 698737003328 active site 698737003329 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 698737003330 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698737003331 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698737003332 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 698737003333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737003334 S-adenosylmethionine binding site [chemical binding]; other site 698737003335 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 698737003336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737003337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737003338 putative substrate translocation pore; other site 698737003339 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698737003340 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 698737003341 HIGH motif; other site 698737003342 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698737003343 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 698737003344 active site 698737003345 KMSKS motif; other site 698737003346 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698737003347 tRNA binding surface [nucleotide binding]; other site 698737003348 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698737003349 active site residue [active] 698737003350 HI0933-like protein; Region: HI0933_like; pfam03486 698737003351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698737003352 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 698737003353 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698737003354 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698737003355 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737003356 RNA binding surface [nucleotide binding]; other site 698737003357 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 698737003358 active site 698737003359 uracil binding [chemical binding]; other site 698737003360 YtxH-like protein; Region: YtxH; pfam12732 698737003361 dipeptidase PepV; Reviewed; Region: PRK07318 698737003362 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 698737003363 active site 698737003364 metal binding site [ion binding]; metal-binding site 698737003365 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698737003366 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 698737003367 homodimer interface [polypeptide binding]; other site 698737003368 substrate-cofactor binding pocket; other site 698737003369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737003370 catalytic residue [active] 698737003371 Phosphotransferase enzyme family; Region: APH; pfam01636 698737003372 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 698737003373 active site 698737003374 substrate binding site [chemical binding]; other site 698737003375 ATP binding site [chemical binding]; other site 698737003376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737003377 S-adenosylmethionine binding site [chemical binding]; other site 698737003378 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 698737003379 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698737003380 Predicted small secreted protein [Function unknown]; Region: COG5584 698737003381 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 698737003382 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 698737003383 oligomer interface [polypeptide binding]; other site 698737003384 active site 698737003385 metal binding site [ion binding]; metal-binding site 698737003386 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737003387 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698737003388 catalytic residues [active] 698737003389 hypothetical protein; Provisional; Region: PRK13668 698737003390 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698737003391 putative tRNA-binding site [nucleotide binding]; other site 698737003392 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698737003393 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698737003394 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 698737003395 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698737003396 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698737003397 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737003398 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737003399 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 698737003400 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 698737003401 Chorismate mutase type II; Region: CM_2; cl00693 698737003402 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 698737003403 catabolite control protein A; Region: ccpA; TIGR01481 698737003404 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698737003405 DNA binding site [nucleotide binding] 698737003406 domain linker motif; other site 698737003407 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 698737003408 dimerization interface [polypeptide binding]; other site 698737003409 effector binding site; other site 698737003410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 698737003411 acetoin reductase; Validated; Region: PRK08643 698737003412 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 698737003413 NAD binding site [chemical binding]; other site 698737003414 homotetramer interface [polypeptide binding]; other site 698737003415 homodimer interface [polypeptide binding]; other site 698737003416 active site 698737003417 substrate binding site [chemical binding]; other site 698737003418 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 698737003419 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 698737003420 active site 698737003421 Zn binding site [ion binding]; other site 698737003422 acetyl-CoA synthetase; Provisional; Region: PRK04319 698737003423 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 698737003424 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 698737003425 active site 698737003426 acyl-activating enzyme (AAE) consensus motif; other site 698737003427 putative CoA binding site [chemical binding]; other site 698737003428 AMP binding site [chemical binding]; other site 698737003429 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698737003430 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698737003431 Potassium binding sites [ion binding]; other site 698737003432 Cesium cation binding sites [ion binding]; other site 698737003433 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698737003434 Transglycosylase; Region: Transgly; pfam00912 698737003435 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698737003436 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 698737003437 active site 698737003438 HIGH motif; other site 698737003439 dimer interface [polypeptide binding]; other site 698737003440 KMSKS motif; other site 698737003441 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737003442 RNA binding surface [nucleotide binding]; other site 698737003443 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 698737003444 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698737003445 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698737003446 protein binding site [polypeptide binding]; other site 698737003447 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 698737003448 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698737003449 putative acyl-acceptor binding pocket; other site 698737003450 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 698737003451 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698737003452 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737003453 active site turn [active] 698737003454 phosphorylation site [posttranslational modification] 698737003455 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698737003456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737003457 motif II; other site 698737003458 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698737003459 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 698737003460 ligand binding site [chemical binding]; other site 698737003461 NAD binding site [chemical binding]; other site 698737003462 dimerization interface [polypeptide binding]; other site 698737003463 catalytic site [active] 698737003464 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698737003465 putative L-serine binding site [chemical binding]; other site 698737003466 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 698737003467 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737003468 catalytic residue [active] 698737003469 OsmC-like protein; Region: OsmC; cl00767 698737003470 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698737003471 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 698737003472 active site 698737003473 catalytic site [active] 698737003474 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698737003475 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698737003476 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737003477 RNA binding surface [nucleotide binding]; other site 698737003478 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 698737003479 GAF domain; Region: GAF_2; pfam13185 698737003480 septation ring formation regulator EzrA; Provisional; Region: PRK04778 698737003481 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698737003482 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 698737003483 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737003484 catalytic residue [active] 698737003485 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 698737003486 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 698737003487 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 698737003488 Ligand Binding Site [chemical binding]; other site 698737003489 hypothetical protein; Provisional; Region: PRK10621 698737003490 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698737003491 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698737003492 dimer interface [polypeptide binding]; other site 698737003493 catalytic triad [active] 698737003494 peroxidatic and resolving cysteines [active] 698737003495 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 698737003496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737003497 S-adenosylmethionine binding site [chemical binding]; other site 698737003498 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 698737003499 propionate/acetate kinase; Provisional; Region: PRK12379 698737003500 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698737003501 Ligand Binding Site [chemical binding]; other site 698737003502 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 698737003503 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 698737003504 hexamer interface [polypeptide binding]; other site 698737003505 ligand binding site [chemical binding]; other site 698737003506 putative active site [active] 698737003507 NAD(P) binding site [chemical binding]; other site 698737003508 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698737003509 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698737003510 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698737003511 active site 698737003512 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698737003513 metal-dependent hydrolase; Provisional; Region: PRK00685 698737003514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698737003515 Ligand Binding Site [chemical binding]; other site 698737003516 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 698737003517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 698737003518 DNA-binding site [nucleotide binding]; DNA binding site 698737003519 DRTGG domain; Region: DRTGG; pfam07085 698737003520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 698737003521 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698737003522 DHH family; Region: DHH; pfam01368 698737003523 DHHA1 domain; Region: DHHA1; pfam02272 698737003524 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 698737003525 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 698737003526 active site 698737003527 PHP Thumb interface [polypeptide binding]; other site 698737003528 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698737003529 generic binding surface I; other site 698737003530 generic binding surface II; other site 698737003531 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 698737003532 Malic enzyme, N-terminal domain; Region: malic; pfam00390 698737003533 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 698737003534 putative NAD(P) binding site [chemical binding]; other site 698737003535 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 698737003536 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 698737003537 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 698737003538 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 698737003539 6-phosphofructokinase; Provisional; Region: PRK03202 698737003540 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 698737003541 active site 698737003542 ADP/pyrophosphate binding site [chemical binding]; other site 698737003543 dimerization interface [polypeptide binding]; other site 698737003544 allosteric effector site; other site 698737003545 fructose-1,6-bisphosphate binding site; other site 698737003546 pyruvate kinase; Provisional; Region: PRK06354 698737003547 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 698737003548 domain interfaces; other site 698737003549 active site 698737003550 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 698737003551 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698737003552 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 698737003553 dimer interface [polypeptide binding]; other site 698737003554 Citrate synthase; Region: Citrate_synt; pfam00285 698737003555 active site 698737003556 citrylCoA binding site [chemical binding]; other site 698737003557 oxalacetate/citrate binding site [chemical binding]; other site 698737003558 coenzyme A binding site [chemical binding]; other site 698737003559 catalytic triad [active] 698737003560 isocitrate dehydrogenase; Reviewed; Region: PRK07006 698737003561 isocitrate dehydrogenase; Validated; Region: PRK07362 698737003562 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737003563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737003564 active site 698737003565 phosphorylation site [posttranslational modification] 698737003566 intermolecular recognition site; other site 698737003567 dimerization interface [polypeptide binding]; other site 698737003568 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737003569 DNA binding site [nucleotide binding] 698737003570 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698737003571 PAS domain; Region: PAS; smart00091 698737003572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737003573 dimer interface [polypeptide binding]; other site 698737003574 phosphorylation site [posttranslational modification] 698737003575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737003576 ATP binding site [chemical binding]; other site 698737003577 Mg2+ binding site [ion binding]; other site 698737003578 G-X-G motif; other site 698737003579 DNA polymerase I; Provisional; Region: PRK05755 698737003580 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698737003581 active site 698737003582 metal binding site 1 [ion binding]; metal-binding site 698737003583 putative 5' ssDNA interaction site; other site 698737003584 metal binding site 3; metal-binding site 698737003585 metal binding site 2 [ion binding]; metal-binding site 698737003586 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698737003587 putative DNA binding site [nucleotide binding]; other site 698737003588 putative metal binding site [ion binding]; other site 698737003589 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698737003590 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698737003591 active site 698737003592 DNA binding site [nucleotide binding] 698737003593 catalytic site [active] 698737003594 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698737003595 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698737003596 DNA binding site [nucleotide binding] 698737003597 catalytic residue [active] 698737003598 H2TH interface [polypeptide binding]; other site 698737003599 putative catalytic residues [active] 698737003600 turnover-facilitating residue; other site 698737003601 intercalation triad [nucleotide binding]; other site 698737003602 8OG recognition residue [nucleotide binding]; other site 698737003603 putative reading head residues; other site 698737003604 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698737003605 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698737003606 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698737003607 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698737003608 CoA-binding site [chemical binding]; other site 698737003609 ATP-binding [chemical binding]; other site 698737003610 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 698737003611 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 698737003612 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698737003613 biotin synthase; Validated; Region: PRK06256 698737003614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737003615 FeS/SAM binding site; other site 698737003616 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 698737003617 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698737003618 ATP cone domain; Region: ATP-cone; pfam03477 698737003619 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 698737003620 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 698737003621 primosomal protein DnaI; Reviewed; Region: PRK08939 698737003622 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 698737003623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737003624 Walker A motif; other site 698737003625 ATP binding site [chemical binding]; other site 698737003626 Walker B motif; other site 698737003627 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 698737003628 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 698737003629 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698737003630 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698737003631 active site 698737003632 dimer interface [polypeptide binding]; other site 698737003633 motif 1; other site 698737003634 motif 2; other site 698737003635 motif 3; other site 698737003636 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698737003637 anticodon binding site; other site 698737003638 lysine transporter; Provisional; Region: PRK10836 698737003639 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 698737003640 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698737003641 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698737003642 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 698737003643 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698737003644 23S rRNA binding site [nucleotide binding]; other site 698737003645 L21 binding site [polypeptide binding]; other site 698737003646 L13 binding site [polypeptide binding]; other site 698737003647 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 698737003648 trigger factor; Provisional; Region: tig; PRK01490 698737003649 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 698737003650 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698737003651 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698737003652 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 698737003653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737003654 Walker A motif; other site 698737003655 ATP binding site [chemical binding]; other site 698737003656 Walker B motif; other site 698737003657 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698737003658 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 698737003659 G1 box; other site 698737003660 GTP/Mg2+ binding site [chemical binding]; other site 698737003661 Switch I region; other site 698737003662 G2 box; other site 698737003663 G3 box; other site 698737003664 Switch II region; other site 698737003665 G4 box; other site 698737003666 G5 box; other site 698737003667 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698737003668 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698737003669 tRNA; other site 698737003670 putative tRNA binding site [nucleotide binding]; other site 698737003671 putative NADP binding site [chemical binding]; other site 698737003672 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698737003673 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 698737003674 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698737003675 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 698737003676 domain interfaces; other site 698737003677 active site 698737003678 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 698737003679 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698737003680 active site 698737003681 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698737003682 dimer interface [polypeptide binding]; other site 698737003683 active site 698737003684 Schiff base residues; other site 698737003685 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698737003686 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698737003687 inhibitor-cofactor binding pocket; inhibition site 698737003688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737003689 catalytic residue [active] 698737003690 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698737003691 Putative ammonia monooxygenase; Region: AmoA; pfam05145 698737003692 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698737003693 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 698737003694 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698737003695 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698737003696 active site 698737003697 HIGH motif; other site 698737003698 nucleotide binding site [chemical binding]; other site 698737003699 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698737003700 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698737003701 active site 698737003702 KMSKS motif; other site 698737003703 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698737003704 tRNA binding surface [nucleotide binding]; other site 698737003705 anticodon binding site; other site 698737003706 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698737003707 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698737003708 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737003709 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737003710 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 698737003711 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 698737003712 hypothetical protein; Reviewed; Region: PRK00024 698737003713 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 698737003714 MPN+ (JAMM) motif; other site 698737003715 Zinc-binding site [ion binding]; other site 698737003716 rod shape-determining protein MreC; Provisional; Region: PRK13922 698737003717 rod shape-determining protein MreC; Region: MreC; pfam04085 698737003718 rod shape-determining protein MreD; Region: MreD; cl01087 698737003719 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 698737003720 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 698737003721 Protein of unknown function (DUF464); Region: DUF464; cl01080 698737003722 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 698737003723 GTPase CgtA; Reviewed; Region: obgE; PRK12297 698737003724 GTP1/OBG; Region: GTP1_OBG; pfam01018 698737003725 Obg GTPase; Region: Obg; cd01898 698737003726 G1 box; other site 698737003727 GTP/Mg2+ binding site [chemical binding]; other site 698737003728 Switch I region; other site 698737003729 G2 box; other site 698737003730 G3 box; other site 698737003731 Switch II region; other site 698737003732 G4 box; other site 698737003733 G5 box; other site 698737003734 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 698737003735 hypothetical protein; Provisional; Region: PRK04435 698737003736 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 698737003737 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698737003738 RuvA N terminal domain; Region: RuvA_N; pfam01330 698737003739 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698737003740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737003741 Walker A motif; other site 698737003742 ATP binding site [chemical binding]; other site 698737003743 Walker B motif; other site 698737003744 arginine finger; other site 698737003745 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698737003746 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 698737003747 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 698737003748 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 698737003749 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698737003750 Preprotein translocase subunit; Region: YajC; pfam02699 698737003751 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 698737003752 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 698737003753 Protein export membrane protein; Region: SecD_SecF; cl14618 698737003754 Protein export membrane protein; Region: SecD_SecF; pfam02355 698737003755 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 698737003756 DHH family; Region: DHH; pfam01368 698737003757 DHHA1 domain; Region: DHHA1; pfam02272 698737003758 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 698737003759 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737003760 active site 698737003761 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698737003762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737003763 Zn2+ binding site [ion binding]; other site 698737003764 Mg2+ binding site [ion binding]; other site 698737003765 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698737003766 synthetase active site [active] 698737003767 NTP binding site [chemical binding]; other site 698737003768 metal binding site [ion binding]; metal-binding site 698737003769 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698737003770 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698737003771 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698737003772 putative active site [active] 698737003773 dimerization interface [polypeptide binding]; other site 698737003774 putative tRNAtyr binding site [nucleotide binding]; other site 698737003775 Bacterial SH3 domain; Region: SH3_3; pfam08239 698737003776 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698737003777 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698737003778 active site 698737003779 metal binding site [ion binding]; metal-binding site 698737003780 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698737003781 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 698737003782 dimer interface [polypeptide binding]; other site 698737003783 motif 1; other site 698737003784 active site 698737003785 motif 2; other site 698737003786 motif 3; other site 698737003787 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698737003788 anticodon binding site; other site 698737003789 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698737003790 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698737003791 dimer interface [polypeptide binding]; other site 698737003792 anticodon binding site; other site 698737003793 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698737003794 homodimer interface [polypeptide binding]; other site 698737003795 motif 1; other site 698737003796 active site 698737003797 motif 2; other site 698737003798 GAD domain; Region: GAD; pfam02938 698737003799 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 698737003800 motif 3; other site 698737003801 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 698737003802 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 698737003803 putative ATP binding site [chemical binding]; other site 698737003804 putative substrate interface [chemical binding]; other site 698737003805 recombination factor protein RarA; Reviewed; Region: PRK13342 698737003806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737003807 Walker A motif; other site 698737003808 ATP binding site [chemical binding]; other site 698737003809 Walker B motif; other site 698737003810 arginine finger; other site 698737003811 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698737003812 Predicted transcriptional regulator [Transcription]; Region: COG1959 698737003813 Transcriptional regulator; Region: Rrf2; pfam02082 698737003814 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 698737003815 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698737003816 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 698737003817 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 698737003818 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737003819 catalytic residue [active] 698737003820 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 698737003821 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698737003822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698737003823 TPR motif; other site 698737003824 binding surface 698737003825 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698737003826 binding surface 698737003827 TPR motif; other site 698737003828 TPR repeat; Region: TPR_11; pfam13414 698737003829 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 698737003830 AAA domain; Region: AAA_30; pfam13604 698737003831 Family description; Region: UvrD_C_2; pfam13538 698737003832 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698737003833 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 698737003834 motif 1; other site 698737003835 active site 698737003836 motif 2; other site 698737003837 motif 3; other site 698737003838 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 698737003839 DHHA1 domain; Region: DHHA1; pfam02272 698737003840 hypothetical protein; Provisional; Region: PRK05473 698737003841 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 698737003842 hypothetical protein; Provisional; Region: PRK13678 698737003843 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698737003844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737003845 S-adenosylmethionine binding site [chemical binding]; other site 698737003846 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 698737003847 Peptidase family U32; Region: Peptidase_U32; pfam01136 698737003848 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 698737003849 Peptidase family U32; Region: Peptidase_U32; pfam01136 698737003850 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 698737003851 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 698737003852 Sugar specificity; other site 698737003853 Pyrimidine base specificity; other site 698737003854 ATP-binding site [chemical binding]; other site 698737003855 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698737003856 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698737003857 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698737003858 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 698737003859 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 698737003860 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 698737003861 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 698737003862 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698737003863 carboxyltransferase (CT) interaction site; other site 698737003864 biotinylation site [posttranslational modification]; other site 698737003865 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737003866 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 698737003867 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698737003868 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698737003869 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 698737003870 putative active site [active] 698737003871 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 698737003872 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 698737003873 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 698737003874 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 698737003875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737003876 active site 698737003877 motif I; other site 698737003878 motif II; other site 698737003879 GTPase YqeH; Provisional; Region: PRK13796 698737003880 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 698737003881 GTP/Mg2+ binding site [chemical binding]; other site 698737003882 G4 box; other site 698737003883 G5 box; other site 698737003884 G1 box; other site 698737003885 Switch I region; other site 698737003886 G2 box; other site 698737003887 G3 box; other site 698737003888 Switch II region; other site 698737003889 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698737003890 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698737003891 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698737003892 shikimate binding site; other site 698737003893 NAD(P) binding site [chemical binding]; other site 698737003894 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 698737003895 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698737003896 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 698737003897 active site 698737003898 (T/H)XGH motif; other site 698737003899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737003900 Zn2+ binding site [ion binding]; other site 698737003901 Mg2+ binding site [ion binding]; other site 698737003902 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 698737003903 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 698737003904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737003905 S-adenosylmethionine binding site [chemical binding]; other site 698737003906 SLBB domain; Region: SLBB; pfam10531 698737003907 comEA protein; Region: comE; TIGR01259 698737003908 Helix-hairpin-helix motif; Region: HHH; pfam00633 698737003909 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698737003910 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 698737003911 catalytic motif [active] 698737003912 Zn binding site [ion binding]; other site 698737003913 Competence protein; Region: Competence; pfam03772 698737003914 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698737003915 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 698737003916 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698737003917 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 698737003918 GTP-binding protein LepA; Provisional; Region: PRK05433 698737003919 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698737003920 G1 box; other site 698737003921 putative GEF interaction site [polypeptide binding]; other site 698737003922 GTP/Mg2+ binding site [chemical binding]; other site 698737003923 Switch I region; other site 698737003924 G2 box; other site 698737003925 G3 box; other site 698737003926 Switch II region; other site 698737003927 G4 box; other site 698737003928 G5 box; other site 698737003929 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698737003930 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698737003931 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698737003932 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 698737003933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737003934 FeS/SAM binding site; other site 698737003935 HemN C-terminal domain; Region: HemN_C; pfam06969 698737003936 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 698737003937 heat shock protein GrpE; Provisional; Region: PRK14140 698737003938 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698737003939 dimer interface [polypeptide binding]; other site 698737003940 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698737003941 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698737003942 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 698737003943 nucleotide binding site [chemical binding]; other site 698737003944 NEF interaction site [polypeptide binding]; other site 698737003945 SBD interface [polypeptide binding]; other site 698737003946 chaperone protein DnaJ; Provisional; Region: PRK14280 698737003947 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698737003948 HSP70 interaction site [polypeptide binding]; other site 698737003949 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 698737003950 substrate binding site [polypeptide binding]; other site 698737003951 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698737003952 Zn binding sites [ion binding]; other site 698737003953 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698737003954 dimer interface [polypeptide binding]; other site 698737003955 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 698737003956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737003957 S-adenosylmethionine binding site [chemical binding]; other site 698737003958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 698737003959 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 698737003960 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698737003961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737003962 FeS/SAM binding site; other site 698737003963 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 698737003964 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 698737003965 hypothetical protein; Provisional; Region: PRK13665 698737003966 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698737003967 PhoH-like protein; Region: PhoH; pfam02562 698737003968 metal-binding heat shock protein; Provisional; Region: PRK00016 698737003969 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 698737003970 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 698737003971 active site 698737003972 catalytic motif [active] 698737003973 Zn binding site [ion binding]; other site 698737003974 GTPase Era; Reviewed; Region: era; PRK00089 698737003975 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698737003976 G1 box; other site 698737003977 GTP/Mg2+ binding site [chemical binding]; other site 698737003978 Switch I region; other site 698737003979 G2 box; other site 698737003980 Switch II region; other site 698737003981 G3 box; other site 698737003982 G4 box; other site 698737003983 G5 box; other site 698737003984 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 698737003985 DNA repair protein RecO; Region: reco; TIGR00613 698737003986 Recombination protein O N terminal; Region: RecO_N; pfam11967 698737003987 Recombination protein O C terminal; Region: RecO_C; pfam02565 698737003988 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698737003989 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698737003990 motif 1; other site 698737003991 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 698737003992 active site 698737003993 motif 2; other site 698737003994 motif 3; other site 698737003995 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698737003996 anticodon binding site; other site 698737003997 FOG: CBS domain [General function prediction only]; Region: COG0517 698737003998 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 698737003999 PEP synthetase regulatory protein; Provisional; Region: PRK05339 698737004000 DNA primase; Validated; Region: dnaG; PRK05667 698737004001 CHC2 zinc finger; Region: zf-CHC2; pfam01807 698737004002 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698737004003 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698737004004 active site 698737004005 metal binding site [ion binding]; metal-binding site 698737004006 interdomain interaction site; other site 698737004007 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 698737004008 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 698737004009 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698737004010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698737004011 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698737004012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698737004013 DNA binding residues [nucleotide binding] 698737004014 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 698737004015 Family of unknown function (DUF633); Region: DUF633; pfam04816 698737004016 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698737004017 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698737004018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698737004019 Uncharacterized conserved protein [Function unknown]; Region: COG0327 698737004020 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 698737004021 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 698737004022 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698737004023 ATP binding site [chemical binding]; other site 698737004024 Mg++ binding site [ion binding]; other site 698737004025 motif III; other site 698737004026 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737004027 nucleotide binding region [chemical binding]; other site 698737004028 ATP-binding site [chemical binding]; other site 698737004029 endonuclease IV; Provisional; Region: PRK01060 698737004030 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 698737004031 AP (apurinic/apyrimidinic) site pocket; other site 698737004032 DNA interaction; other site 698737004033 Metal-binding active site; metal-binding site 698737004034 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698737004035 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698737004036 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698737004037 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737004038 ABC-ATPase subunit interface; other site 698737004039 dimer interface [polypeptide binding]; other site 698737004040 putative PBP binding regions; other site 698737004041 ferric uptake regulator; Provisional; Region: fur; PRK09462 698737004042 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698737004043 metal binding site 2 [ion binding]; metal-binding site 698737004044 putative DNA binding helix; other site 698737004045 metal binding site 1 [ion binding]; metal-binding site 698737004046 dimer interface [polypeptide binding]; other site 698737004047 structural Zn2+ binding site [ion binding]; other site 698737004048 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698737004049 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698737004050 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698737004051 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698737004052 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698737004053 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698737004054 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698737004055 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698737004056 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 698737004057 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 698737004058 Rhomboid family; Region: Rhomboid; pfam01694 698737004059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 698737004060 binding surface 698737004061 TPR motif; other site 698737004062 TPR repeat; Region: TPR_11; pfam13414 698737004063 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 698737004064 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 698737004065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 698737004066 nucleotide binding site [chemical binding]; other site 698737004067 Uncharacterized conserved protein [Function unknown]; Region: COG0011 698737004068 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698737004069 Type II/IV secretion system protein; Region: T2SE; pfam00437 698737004070 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 698737004071 Walker A motif; other site 698737004072 ATP binding site [chemical binding]; other site 698737004073 Walker B motif; other site 698737004074 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 698737004075 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698737004076 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 698737004077 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 698737004078 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 698737004079 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698737004080 ADP binding site [chemical binding]; other site 698737004081 magnesium binding site [ion binding]; other site 698737004082 putative shikimate binding site; other site 698737004083 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 698737004084 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698737004085 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 698737004086 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 698737004087 tetramer interface [polypeptide binding]; other site 698737004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737004089 catalytic residue [active] 698737004090 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 698737004091 tetramer interface [polypeptide binding]; other site 698737004092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737004093 catalytic residue [active] 698737004094 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698737004095 active site residue [active] 698737004096 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 698737004097 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 698737004098 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698737004099 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698737004100 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698737004101 active site 698737004102 elongation factor P; Validated; Region: PRK00529 698737004103 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698737004104 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698737004105 RNA binding site [nucleotide binding]; other site 698737004106 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698737004107 RNA binding site [nucleotide binding]; other site 698737004108 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 698737004109 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698737004110 carboxyltransferase (CT) interaction site; other site 698737004111 biotinylation site [posttranslational modification]; other site 698737004112 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 698737004113 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737004114 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698737004115 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698737004116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 698737004117 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 698737004118 putative RNA binding site [nucleotide binding]; other site 698737004119 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698737004120 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698737004121 generic binding surface II; other site 698737004122 generic binding surface I; other site 698737004123 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 698737004124 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698737004125 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698737004126 substrate binding pocket [chemical binding]; other site 698737004127 chain length determination region; other site 698737004128 substrate-Mg2+ binding site; other site 698737004129 catalytic residues [active] 698737004130 aspartate-rich region 1; other site 698737004131 active site lid residues [active] 698737004132 aspartate-rich region 2; other site 698737004133 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698737004134 arginine repressor; Provisional; Region: PRK04280 698737004135 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698737004136 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698737004137 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698737004138 Walker A/P-loop; other site 698737004139 ATP binding site [chemical binding]; other site 698737004140 Q-loop/lid; other site 698737004141 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 698737004142 ABC transporter signature motif; other site 698737004143 Walker B; other site 698737004144 D-loop; other site 698737004145 H-loop/switch region; other site 698737004146 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 698737004147 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 698737004148 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 698737004149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737004150 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737004151 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 698737004152 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698737004153 tetramer interface [polypeptide binding]; other site 698737004154 TPP-binding site [chemical binding]; other site 698737004155 heterodimer interface [polypeptide binding]; other site 698737004156 phosphorylation loop region [posttranslational modification] 698737004157 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698737004158 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698737004159 alpha subunit interface [polypeptide binding]; other site 698737004160 TPP binding site [chemical binding]; other site 698737004161 heterodimer interface [polypeptide binding]; other site 698737004162 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698737004163 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737004164 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 698737004165 E3 interaction surface; other site 698737004166 lipoyl attachment site [posttranslational modification]; other site 698737004167 e3 binding domain; Region: E3_binding; pfam02817 698737004168 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698737004169 Disulphide isomerase; Region: Disulph_isomer; pfam06491 698737004170 Predicted membrane protein [Function unknown]; Region: COG4129 698737004171 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 698737004172 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 698737004173 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698737004174 peptidase T-like protein; Region: PepT-like; TIGR01883 698737004175 metal binding site [ion binding]; metal-binding site 698737004176 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 698737004177 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698737004178 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698737004179 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698737004180 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698737004181 DNA binding site [nucleotide binding] 698737004182 domain linker motif; other site 698737004183 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 698737004184 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 698737004185 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 698737004186 Ca binding site [ion binding]; other site 698737004187 active site 698737004188 catalytic site [active] 698737004189 Helix-turn-helix domain; Region: HTH_18; pfam12833 698737004190 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 698737004191 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698737004192 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698737004193 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698737004194 ribonuclease Z; Region: RNase_Z; TIGR02651 698737004195 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 698737004196 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 698737004197 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698737004198 classical (c) SDRs; Region: SDR_c; cd05233 698737004199 NAD(P) binding site [chemical binding]; other site 698737004200 active site 698737004201 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698737004202 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698737004203 active site 698737004204 catalytic tetrad [active] 698737004205 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698737004206 dimer interface [polypeptide binding]; other site 698737004207 ADP-ribose binding site [chemical binding]; other site 698737004208 active site 698737004209 nudix motif; other site 698737004210 metal binding site [ion binding]; metal-binding site 698737004211 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698737004212 metal binding site 2 [ion binding]; metal-binding site 698737004213 putative DNA binding helix; other site 698737004214 metal binding site 1 [ion binding]; metal-binding site 698737004215 dimer interface [polypeptide binding]; other site 698737004216 structural Zn2+ binding site [ion binding]; other site 698737004217 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 698737004218 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698737004219 active site 698737004220 Int/Topo IB signature motif; other site 698737004221 Domain of unknown function (DUF309); Region: DUF309; cl00667 698737004222 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 698737004223 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 698737004224 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698737004225 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737004226 RNA binding surface [nucleotide binding]; other site 698737004227 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698737004228 active site 698737004229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737004230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737004231 active site 698737004232 phosphorylation site [posttranslational modification] 698737004233 intermolecular recognition site; other site 698737004234 dimerization interface [polypeptide binding]; other site 698737004235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737004236 DNA binding site [nucleotide binding] 698737004237 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698737004238 dimerization interface [polypeptide binding]; other site 698737004239 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698737004240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737004241 dimer interface [polypeptide binding]; other site 698737004242 phosphorylation site [posttranslational modification] 698737004243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737004244 ATP binding site [chemical binding]; other site 698737004245 Mg2+ binding site [ion binding]; other site 698737004246 G-X-G motif; other site 698737004247 Predicted membrane protein [Function unknown]; Region: COG3601 698737004248 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 698737004249 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 698737004250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 698737004251 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698737004252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737004253 ATP binding site [chemical binding]; other site 698737004254 putative Mg++ binding site [ion binding]; other site 698737004255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737004256 nucleotide binding region [chemical binding]; other site 698737004257 ATP-binding site [chemical binding]; other site 698737004258 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698737004259 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 698737004260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 698737004261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737004262 Amidohydrolase; Region: Amidohydro_2; pfam04909 698737004263 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698737004264 active site 698737004265 homotetramer interface [polypeptide binding]; other site 698737004266 homodimer interface [polypeptide binding]; other site 698737004267 cytidylate kinase; Provisional; Region: cmk; PRK00023 698737004268 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698737004269 CMP-binding site; other site 698737004270 The sites determining sugar specificity; other site 698737004271 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 698737004272 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698737004273 RNA binding site [nucleotide binding]; other site 698737004274 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698737004275 RNA binding site [nucleotide binding]; other site 698737004276 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698737004277 RNA binding site [nucleotide binding]; other site 698737004278 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698737004279 RNA binding site [nucleotide binding]; other site 698737004280 GTP-binding protein Der; Reviewed; Region: PRK00093 698737004281 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698737004282 G1 box; other site 698737004283 GTP/Mg2+ binding site [chemical binding]; other site 698737004284 Switch I region; other site 698737004285 G2 box; other site 698737004286 Switch II region; other site 698737004287 G3 box; other site 698737004288 G4 box; other site 698737004289 G5 box; other site 698737004290 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698737004291 G1 box; other site 698737004292 GTP/Mg2+ binding site [chemical binding]; other site 698737004293 Switch I region; other site 698737004294 G2 box; other site 698737004295 G3 box; other site 698737004296 Switch II region; other site 698737004297 G4 box; other site 698737004298 G5 box; other site 698737004299 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698737004300 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 698737004301 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698737004302 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 698737004303 IHF dimer interface [polypeptide binding]; other site 698737004304 IHF - DNA interface [nucleotide binding]; other site 698737004305 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 698737004306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737004307 S-adenosylmethionine binding site [chemical binding]; other site 698737004308 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698737004309 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698737004310 substrate binding pocket [chemical binding]; other site 698737004311 chain length determination region; other site 698737004312 substrate-Mg2+ binding site; other site 698737004313 catalytic residues [active] 698737004314 aspartate-rich region 1; other site 698737004315 active site lid residues [active] 698737004316 aspartate-rich region 2; other site 698737004317 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698737004318 active site 698737004319 multimer interface [polypeptide binding]; other site 698737004320 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 698737004321 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698737004322 Tetramer interface [polypeptide binding]; other site 698737004323 active site 698737004324 FMN-binding site [chemical binding]; other site 698737004325 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698737004326 active site 698737004327 dimer interface [polypeptide binding]; other site 698737004328 metal binding site [ion binding]; metal-binding site 698737004329 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 698737004330 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698737004331 hinge; other site 698737004332 active site 698737004333 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 698737004334 tetratricopeptide repeat protein; Provisional; Region: PRK11788 698737004335 Uncharacterized conserved protein [Function unknown]; Region: COG5582 698737004336 UPF0302 domain; Region: UPF0302; pfam08864 698737004337 IDEAL domain; Region: IDEAL; cl07452 698737004338 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 698737004339 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 698737004340 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 698737004341 homodimer interface [polypeptide binding]; other site 698737004342 metal binding site [ion binding]; metal-binding site 698737004343 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 698737004344 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 698737004345 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 698737004346 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698737004347 active site 698737004348 NTP binding site [chemical binding]; other site 698737004349 metal binding triad [ion binding]; metal-binding site 698737004350 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698737004351 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 698737004352 Biotin operon repressor [Transcription]; Region: BirA; COG1654 698737004353 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698737004354 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698737004355 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 698737004356 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 698737004357 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698737004358 active site 698737004359 catalytic site [active] 698737004360 substrate binding site [chemical binding]; other site 698737004361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698737004362 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 698737004363 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 698737004364 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 698737004365 putative dimer interface [polypeptide binding]; other site 698737004366 putative anticodon binding site; other site 698737004367 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 698737004368 homodimer interface [polypeptide binding]; other site 698737004369 motif 1; other site 698737004370 motif 2; other site 698737004371 active site 698737004372 motif 3; other site 698737004373 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 698737004374 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 698737004375 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698737004376 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698737004377 minor groove reading motif; other site 698737004378 helix-hairpin-helix signature motif; other site 698737004379 substrate binding pocket [chemical binding]; other site 698737004380 active site 698737004381 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 698737004382 Transglycosylase; Region: Transgly; pfam00912 698737004383 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 698737004384 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 698737004385 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 698737004386 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 698737004387 hypothetical protein; Provisional; Region: PRK13660 698737004388 cell division protein GpsB; Provisional; Region: PRK14127 698737004389 DivIVA domain; Region: DivI1A_domain; TIGR03544 698737004390 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 698737004391 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 698737004392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 698737004393 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 698737004394 NADH(P)-binding; Region: NAD_binding_10; pfam13460 698737004395 putative NAD(P) binding site [chemical binding]; other site 698737004396 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 698737004397 Dynamin family; Region: Dynamin_N; pfam00350 698737004398 G1 box; other site 698737004399 GTP/Mg2+ binding site [chemical binding]; other site 698737004400 G2 box; other site 698737004401 Switch I region; other site 698737004402 G3 box; other site 698737004403 Switch II region; other site 698737004404 G4 box; other site 698737004405 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698737004406 Dynamin family; Region: Dynamin_N; pfam00350 698737004407 G1 box; other site 698737004408 GTP/Mg2+ binding site [chemical binding]; other site 698737004409 G2 box; other site 698737004410 Switch I region; other site 698737004411 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 698737004412 G3 box; other site 698737004413 Switch II region; other site 698737004414 GTP/Mg2+ binding site [chemical binding]; other site 698737004415 G4 box; other site 698737004416 G5 box; other site 698737004417 5'-3' exonuclease; Region: 53EXOc; smart00475 698737004418 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698737004419 active site 698737004420 metal binding site 1 [ion binding]; metal-binding site 698737004421 putative 5' ssDNA interaction site; other site 698737004422 metal binding site 3; metal-binding site 698737004423 metal binding site 2 [ion binding]; metal-binding site 698737004424 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698737004425 putative DNA binding site [nucleotide binding]; other site 698737004426 putative metal binding site [ion binding]; other site 698737004427 anthranilate synthase component I; Provisional; Region: PRK13567 698737004428 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698737004429 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 698737004430 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698737004431 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698737004432 glutamine binding [chemical binding]; other site 698737004433 catalytic triad [active] 698737004434 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698737004435 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698737004436 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698737004437 active site 698737004438 ribulose/triose binding site [chemical binding]; other site 698737004439 phosphate binding site [ion binding]; other site 698737004440 substrate (anthranilate) binding pocket [chemical binding]; other site 698737004441 product (indole) binding pocket [chemical binding]; other site 698737004442 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 698737004443 active site 698737004444 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 698737004445 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698737004446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737004447 catalytic residue [active] 698737004448 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 698737004449 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698737004450 substrate binding site [chemical binding]; other site 698737004451 active site 698737004452 catalytic residues [active] 698737004453 heterodimer interface [polypeptide binding]; other site 698737004454 FemAB family; Region: FemAB; pfam02388 698737004455 FemAB family; Region: FemAB; pfam02388 698737004456 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 698737004457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737004458 active site 698737004459 motif I; other site 698737004460 motif II; other site 698737004461 potential frameshift: common BLAST hit: gi|57866906|ref|YP_188527.1| transferrin receptor 698737004462 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737004463 intersubunit interface [polypeptide binding]; other site 698737004464 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737004465 oligoendopeptidase F; Region: pepF; TIGR00181 698737004466 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 698737004467 active site 698737004468 Zn binding site [ion binding]; other site 698737004469 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698737004470 PhoU domain; Region: PhoU; pfam01895 698737004471 PhoU domain; Region: PhoU; pfam01895 698737004472 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 698737004473 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 698737004474 Walker A/P-loop; other site 698737004475 ATP binding site [chemical binding]; other site 698737004476 Q-loop/lid; other site 698737004477 ABC transporter signature motif; other site 698737004478 Walker B; other site 698737004479 D-loop; other site 698737004480 H-loop/switch region; other site 698737004481 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 698737004482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737004483 dimer interface [polypeptide binding]; other site 698737004484 conserved gate region; other site 698737004485 ABC-ATPase subunit interface; other site 698737004486 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 698737004487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737004488 dimer interface [polypeptide binding]; other site 698737004489 conserved gate region; other site 698737004490 putative PBP binding loops; other site 698737004491 ABC-ATPase subunit interface; other site 698737004492 PBP superfamily domain; Region: PBP_like_2; cl17296 698737004493 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 698737004494 S1 domain; Region: S1_2; pfam13509 698737004495 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 698737004496 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737004497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737004498 ABC transporter; Region: ABC_tran_2; pfam12848 698737004499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737004500 aspartate kinase; Reviewed; Region: PRK06635 698737004501 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698737004502 putative nucleotide binding site [chemical binding]; other site 698737004503 putative catalytic residues [active] 698737004504 putative Mg ion binding site [ion binding]; other site 698737004505 putative aspartate binding site [chemical binding]; other site 698737004506 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 698737004507 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 698737004508 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698737004509 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 698737004510 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698737004511 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698737004512 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698737004513 dimer interface [polypeptide binding]; other site 698737004514 active site 698737004515 catalytic residue [active] 698737004516 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698737004517 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 698737004518 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698737004519 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 698737004520 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 698737004521 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 698737004522 active site 698737004523 trimer interface [polypeptide binding]; other site 698737004524 substrate binding site [chemical binding]; other site 698737004525 CoA binding site [chemical binding]; other site 698737004526 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698737004527 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 698737004528 metal binding site [ion binding]; metal-binding site 698737004529 dimer interface [polypeptide binding]; other site 698737004530 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 698737004531 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 698737004532 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737004533 catalytic residue [active] 698737004534 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 698737004535 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698737004536 active site 698737004537 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737004538 substrate binding site [chemical binding]; other site 698737004539 catalytic residues [active] 698737004540 dimer interface [polypeptide binding]; other site 698737004541 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 698737004542 DNA-binding site [nucleotide binding]; DNA binding site 698737004543 RNA-binding motif; other site 698737004544 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 698737004545 acylphosphatase; Provisional; Region: PRK14431 698737004546 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 698737004547 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 698737004548 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 698737004549 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 698737004550 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 698737004551 metal ion-dependent adhesion site (MIDAS); other site 698737004552 MoxR-like ATPases [General function prediction only]; Region: COG0714 698737004553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737004554 Walker A motif; other site 698737004555 ATP binding site [chemical binding]; other site 698737004556 Walker B motif; other site 698737004557 arginine finger; other site 698737004558 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 698737004559 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737004560 active site 698737004561 metal binding site [ion binding]; metal-binding site 698737004562 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737004563 active site 698737004564 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 698737004565 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737004566 E3 interaction surface; other site 698737004567 lipoyl attachment site [posttranslational modification]; other site 698737004568 e3 binding domain; Region: E3_binding; pfam02817 698737004569 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698737004570 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 698737004571 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698737004572 TPP-binding site [chemical binding]; other site 698737004573 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 698737004574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737004575 HAMP domain; Region: HAMP; pfam00672 698737004576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737004577 dimer interface [polypeptide binding]; other site 698737004578 phosphorylation site [posttranslational modification] 698737004579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737004580 ATP binding site [chemical binding]; other site 698737004581 Mg2+ binding site [ion binding]; other site 698737004582 G-X-G motif; other site 698737004583 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737004584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737004585 active site 698737004586 phosphorylation site [posttranslational modification] 698737004587 intermolecular recognition site; other site 698737004588 dimerization interface [polypeptide binding]; other site 698737004589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737004590 DNA binding site [nucleotide binding] 698737004591 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 698737004592 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698737004593 active site 698737004594 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698737004595 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698737004596 active site 698737004597 homodimer interface [polypeptide binding]; other site 698737004598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 698737004599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737004600 Coenzyme A binding pocket [chemical binding]; other site 698737004601 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 698737004602 C-terminal peptidase (prc); Region: prc; TIGR00225 698737004603 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 698737004604 protein binding site [polypeptide binding]; other site 698737004605 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 698737004606 Catalytic dyad [active] 698737004607 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 698737004608 hypothetical protein; Provisional; Region: PRK13672 698737004609 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 698737004610 HPr interaction site; other site 698737004611 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698737004612 active site 698737004613 phosphorylation site [posttranslational modification] 698737004614 methionine sulfoxide reductase B; Provisional; Region: PRK00222 698737004615 SelR domain; Region: SelR; pfam01641 698737004616 methionine sulfoxide reductase A; Provisional; Region: PRK13014 698737004617 EDD domain protein, DegV family; Region: DegV; TIGR00762 698737004618 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698737004619 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 698737004620 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698737004621 folate binding site [chemical binding]; other site 698737004622 NADP+ binding site [chemical binding]; other site 698737004623 thymidylate synthase; Region: thym_sym; TIGR03284 698737004624 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698737004625 dimerization interface [polypeptide binding]; other site 698737004626 active site 698737004627 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 698737004628 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 698737004629 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 698737004630 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 698737004631 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698737004632 RNA/DNA hybrid binding site [nucleotide binding]; other site 698737004633 active site 698737004634 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698737004635 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 698737004636 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698737004637 active site 698737004638 P-loop; other site 698737004639 phosphorylation site [posttranslational modification] 698737004640 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737004641 active site 698737004642 phosphorylation site [posttranslational modification] 698737004643 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 698737004644 active site 698737004645 dimer interface [polypeptide binding]; other site 698737004646 magnesium binding site [ion binding]; other site 698737004647 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 698737004648 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 698737004649 AP (apurinic/apyrimidinic) site pocket; other site 698737004650 DNA interaction; other site 698737004651 Metal-binding active site; metal-binding site 698737004652 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 698737004653 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 698737004654 intersubunit interface [polypeptide binding]; other site 698737004655 active site 698737004656 Zn2+ binding site [ion binding]; other site 698737004657 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 698737004658 PRD domain; Region: PRD; pfam00874 698737004659 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 698737004660 active site 698737004661 P-loop; other site 698737004662 phosphorylation site [posttranslational modification] 698737004663 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 698737004664 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 698737004665 prephenate dehydrogenase; Validated; Region: PRK06545 698737004666 prephenate dehydrogenase; Validated; Region: PRK08507 698737004667 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 698737004668 DNA polymerase IV; Reviewed; Region: PRK03103 698737004669 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 698737004670 active site 698737004671 DNA binding site [nucleotide binding] 698737004672 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 698737004673 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 698737004674 active site 1 [active] 698737004675 dimer interface [polypeptide binding]; other site 698737004676 hexamer interface [polypeptide binding]; other site 698737004677 active site 2 [active] 698737004678 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698737004679 methionine sulfoxide reductase A; Provisional; Region: PRK14054 698737004680 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698737004681 Predicted integral membrane protein [Function unknown]; Region: COG0392 698737004682 Uncharacterized conserved protein [Function unknown]; Region: COG2898 698737004683 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 698737004684 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698737004685 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698737004686 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698737004687 amino acid carrier protein; Region: agcS; TIGR00835 698737004688 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 698737004689 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698737004690 CAP-like domain; other site 698737004691 active site 698737004692 primary dimer interface [polypeptide binding]; other site 698737004693 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737004694 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698737004695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737004696 ATP binding site [chemical binding]; other site 698737004697 Mg2+ binding site [ion binding]; other site 698737004698 G-X-G motif; other site 698737004699 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698737004700 anchoring element; other site 698737004701 dimer interface [polypeptide binding]; other site 698737004702 ATP binding site [chemical binding]; other site 698737004703 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698737004704 active site 698737004705 putative metal-binding site [ion binding]; other site 698737004706 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698737004707 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 698737004708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 698737004709 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698737004710 active site 698737004711 aconitate hydratase; Validated; Region: PRK09277 698737004712 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 698737004713 substrate binding site [chemical binding]; other site 698737004714 ligand binding site [chemical binding]; other site 698737004715 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698737004716 substrate binding site [chemical binding]; other site 698737004717 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 698737004718 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698737004719 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 698737004720 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698737004721 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 698737004722 Walker A/P-loop; other site 698737004723 ATP binding site [chemical binding]; other site 698737004724 Q-loop/lid; other site 698737004725 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 698737004726 ABC transporter signature motif; other site 698737004727 Walker B; other site 698737004728 D-loop; other site 698737004729 H-loop/switch region; other site 698737004730 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698737004731 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698737004732 active site 698737004733 metal binding site [ion binding]; metal-binding site 698737004734 DNA binding site [nucleotide binding] 698737004735 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 698737004736 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 698737004737 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 698737004738 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 698737004739 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698737004740 TPP-binding site [chemical binding]; other site 698737004741 dimer interface [polypeptide binding]; other site 698737004742 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698737004743 PYR/PP interface [polypeptide binding]; other site 698737004744 dimer interface [polypeptide binding]; other site 698737004745 TPP binding site [chemical binding]; other site 698737004746 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698737004747 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 698737004748 LexA repressor; Validated; Region: PRK00215 698737004749 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737004750 putative DNA binding site [nucleotide binding]; other site 698737004751 putative Zn2+ binding site [ion binding]; other site 698737004752 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698737004753 Catalytic site [active] 698737004754 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 698737004755 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 698737004756 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 698737004757 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698737004758 active site 698737004759 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 698737004760 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 698737004761 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698737004762 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 698737004763 tetramer interface [polypeptide binding]; other site 698737004764 heme binding pocket [chemical binding]; other site 698737004765 NADPH binding site [chemical binding]; other site 698737004766 lysine transporter; Provisional; Region: PRK10836 698737004767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737004768 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737004769 active site 698737004770 motif I; other site 698737004771 motif II; other site 698737004772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737004773 homoserine kinase; Provisional; Region: PRK01212 698737004774 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698737004775 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698737004776 threonine synthase; Reviewed; Region: PRK06721 698737004777 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 698737004778 homodimer interface [polypeptide binding]; other site 698737004779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737004780 catalytic residue [active] 698737004781 homoserine dehydrogenase; Provisional; Region: PRK06349 698737004782 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 698737004783 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698737004784 aspartate kinase; Reviewed; Region: PRK09034 698737004785 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 698737004786 nucleotide binding site [chemical binding]; other site 698737004787 substrate binding site [chemical binding]; other site 698737004788 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 698737004789 allosteric regulatory residue; other site 698737004790 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 698737004791 Staphylococcal nuclease homologues; Region: SNc; smart00318 698737004792 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 698737004793 Catalytic site; other site 698737004794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698737004795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737004796 active site 698737004797 phosphorylation site [posttranslational modification] 698737004798 intermolecular recognition site; other site 698737004799 dimerization interface [polypeptide binding]; other site 698737004800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698737004801 DNA binding residues [nucleotide binding] 698737004802 dimerization interface [polypeptide binding]; other site 698737004803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698737004804 Histidine kinase; Region: HisKA_3; pfam07730 698737004805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737004806 ATP binding site [chemical binding]; other site 698737004807 Mg2+ binding site [ion binding]; other site 698737004808 G-X-G motif; other site 698737004809 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 698737004810 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698737004811 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737004812 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 698737004813 Walker A/P-loop; other site 698737004814 ATP binding site [chemical binding]; other site 698737004815 Q-loop/lid; other site 698737004816 ABC transporter signature motif; other site 698737004817 Walker B; other site 698737004818 D-loop; other site 698737004819 H-loop/switch region; other site 698737004820 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698737004821 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 698737004822 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 698737004823 putative active site [active] 698737004824 catalytic site [active] 698737004825 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 698737004826 putative active site [active] 698737004827 catalytic site [active] 698737004828 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 698737004829 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737004830 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737004831 catalytic residue [active] 698737004832 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698737004833 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698737004834 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698737004835 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698737004836 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698737004837 DNA binding residues [nucleotide binding] 698737004838 putative dimer interface [polypeptide binding]; other site 698737004839 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 698737004840 Aluminium resistance protein; Region: Alum_res; pfam06838 698737004841 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 698737004842 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698737004843 HflX GTPase family; Region: HflX; cd01878 698737004844 G1 box; other site 698737004845 GTP/Mg2+ binding site [chemical binding]; other site 698737004846 Switch I region; other site 698737004847 G2 box; other site 698737004848 G3 box; other site 698737004849 Switch II region; other site 698737004850 G4 box; other site 698737004851 G5 box; other site 698737004852 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698737004853 catalytic residues [active] 698737004854 dimer interface [polypeptide binding]; other site 698737004855 bacterial Hfq-like; Region: Hfq; cd01716 698737004856 hexamer interface [polypeptide binding]; other site 698737004857 Sm1 motif; other site 698737004858 RNA binding site [nucleotide binding]; other site 698737004859 Sm2 motif; other site 698737004860 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 698737004861 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698737004862 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698737004863 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698737004864 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698737004865 glycerol kinase; Provisional; Region: glpK; PRK00047 698737004866 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 698737004867 N- and C-terminal domain interface [polypeptide binding]; other site 698737004868 active site 698737004869 MgATP binding site [chemical binding]; other site 698737004870 catalytic site [active] 698737004871 metal binding site [ion binding]; metal-binding site 698737004872 glycerol binding site [chemical binding]; other site 698737004873 homotetramer interface [polypeptide binding]; other site 698737004874 homodimer interface [polypeptide binding]; other site 698737004875 FBP binding site [chemical binding]; other site 698737004876 protein IIAGlc interface [polypeptide binding]; other site 698737004877 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 698737004878 amphipathic channel; other site 698737004879 Asn-Pro-Ala signature motifs; other site 698737004880 Asn-Pro-Ala signature motifs; other site 698737004881 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 698737004882 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 698737004883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737004884 ATP binding site [chemical binding]; other site 698737004885 Mg2+ binding site [ion binding]; other site 698737004886 G-X-G motif; other site 698737004887 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 698737004888 ATP binding site [chemical binding]; other site 698737004889 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 698737004890 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 698737004891 MutS domain I; Region: MutS_I; pfam01624 698737004892 MutS domain II; Region: MutS_II; pfam05188 698737004893 MutS domain III; Region: MutS_III; pfam05192 698737004894 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 698737004895 Walker A/P-loop; other site 698737004896 ATP binding site [chemical binding]; other site 698737004897 Q-loop/lid; other site 698737004898 ABC transporter signature motif; other site 698737004899 Walker B; other site 698737004900 D-loop; other site 698737004901 H-loop/switch region; other site 698737004902 thiW protein; Region: thiW; TIGR02359 698737004903 Predicted membrane protein [Function unknown]; Region: COG4550 698737004904 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 698737004905 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698737004906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737004907 FeS/SAM binding site; other site 698737004908 TRAM domain; Region: TRAM; pfam01938 698737004909 Uncharacterized conserved protein [Function unknown]; Region: COG0011 698737004910 Protein of unknown function (DUF867); Region: DUF867; pfam05908 698737004911 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 698737004912 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 698737004913 TPP-binding site [chemical binding]; other site 698737004914 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 698737004915 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 698737004916 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 698737004917 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 698737004918 dimer interface [polypeptide binding]; other site 698737004919 PYR/PP interface [polypeptide binding]; other site 698737004920 TPP binding site [chemical binding]; other site 698737004921 substrate binding site [chemical binding]; other site 698737004922 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 698737004923 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737004924 putative active site [active] 698737004925 metal binding site [ion binding]; metal-binding site 698737004926 homodimer binding site [polypeptide binding]; other site 698737004927 phosphodiesterase; Provisional; Region: PRK12704 698737004928 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737004929 Zn2+ binding site [ion binding]; other site 698737004930 Mg2+ binding site [ion binding]; other site 698737004931 recombinase A; Provisional; Region: recA; PRK09354 698737004932 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698737004933 hexamer interface [polypeptide binding]; other site 698737004934 Walker A motif; other site 698737004935 ATP binding site [chemical binding]; other site 698737004936 Walker B motif; other site 698737004937 competence damage-inducible protein A; Provisional; Region: PRK00549 698737004938 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 698737004939 putative MPT binding site; other site 698737004940 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 698737004941 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 698737004942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737004943 non-specific DNA binding site [nucleotide binding]; other site 698737004944 salt bridge; other site 698737004945 sequence-specific DNA binding site [nucleotide binding]; other site 698737004946 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698737004947 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 698737004948 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 698737004949 classical (c) SDRs; Region: SDR_c; cd05233 698737004950 NAD(P) binding site [chemical binding]; other site 698737004951 active site 698737004952 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 698737004953 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 698737004954 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698737004955 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 698737004956 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 698737004957 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698737004958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737004959 DNA-binding site [nucleotide binding]; DNA binding site 698737004960 UTRA domain; Region: UTRA; pfam07702 698737004961 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 698737004962 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698737004963 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 698737004964 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698737004965 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698737004966 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698737004967 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 698737004968 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 698737004969 RNase E interface [polypeptide binding]; other site 698737004970 trimer interface [polypeptide binding]; other site 698737004971 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698737004972 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698737004973 RNase E interface [polypeptide binding]; other site 698737004974 trimer interface [polypeptide binding]; other site 698737004975 active site 698737004976 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698737004977 putative nucleic acid binding region [nucleotide binding]; other site 698737004978 G-X-X-G motif; other site 698737004979 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698737004980 RNA binding site [nucleotide binding]; other site 698737004981 domain interface; other site 698737004982 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698737004983 16S/18S rRNA binding site [nucleotide binding]; other site 698737004984 S13e-L30e interaction site [polypeptide binding]; other site 698737004985 25S rRNA binding site [nucleotide binding]; other site 698737004986 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698737004987 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698737004988 active site 698737004989 Riboflavin kinase; Region: Flavokinase; pfam01687 698737004990 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 698737004991 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698737004992 RNA binding site [nucleotide binding]; other site 698737004993 active site 698737004994 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 698737004995 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698737004996 translation initiation factor IF-2; Region: IF-2; TIGR00487 698737004997 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698737004998 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698737004999 G1 box; other site 698737005000 putative GEF interaction site [polypeptide binding]; other site 698737005001 GTP/Mg2+ binding site [chemical binding]; other site 698737005002 Switch I region; other site 698737005003 G2 box; other site 698737005004 G3 box; other site 698737005005 Switch II region; other site 698737005006 G4 box; other site 698737005007 G5 box; other site 698737005008 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698737005009 Translation-initiation factor 2; Region: IF-2; pfam11987 698737005010 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698737005011 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 698737005012 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 698737005013 putative RNA binding cleft [nucleotide binding]; other site 698737005014 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698737005015 NusA N-terminal domain; Region: NusA_N; pfam08529 698737005016 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698737005017 RNA binding site [nucleotide binding]; other site 698737005018 homodimer interface [polypeptide binding]; other site 698737005019 NusA-like KH domain; Region: KH_5; pfam13184 698737005020 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698737005021 G-X-X-G motif; other site 698737005022 ribosome maturation protein RimP; Reviewed; Region: PRK00092 698737005023 Sm and related proteins; Region: Sm_like; cl00259 698737005024 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 698737005025 putative oligomer interface [polypeptide binding]; other site 698737005026 putative RNA binding site [nucleotide binding]; other site 698737005027 DNA polymerase III PolC; Validated; Region: polC; PRK00448 698737005028 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 698737005029 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 698737005030 generic binding surface II; other site 698737005031 generic binding surface I; other site 698737005032 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 698737005033 active site 698737005034 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698737005035 active site 698737005036 catalytic site [active] 698737005037 substrate binding site [chemical binding]; other site 698737005038 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 698737005039 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698737005040 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 698737005041 dimer interface [polypeptide binding]; other site 698737005042 motif 1; other site 698737005043 active site 698737005044 motif 2; other site 698737005045 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698737005046 putative deacylase active site [active] 698737005047 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 698737005048 active site 698737005049 motif 3; other site 698737005050 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698737005051 anticodon binding site; other site 698737005052 RIP metalloprotease RseP; Region: TIGR00054 698737005053 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698737005054 active site 698737005055 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698737005056 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698737005057 protein binding site [polypeptide binding]; other site 698737005058 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698737005059 putative substrate binding region [chemical binding]; other site 698737005060 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 698737005061 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 698737005062 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 698737005063 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 698737005064 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 698737005065 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698737005066 catalytic residue [active] 698737005067 putative FPP diphosphate binding site; other site 698737005068 putative FPP binding hydrophobic cleft; other site 698737005069 dimer interface [polypeptide binding]; other site 698737005070 putative IPP diphosphate binding site; other site 698737005071 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698737005072 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 698737005073 hinge region; other site 698737005074 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698737005075 putative nucleotide binding site [chemical binding]; other site 698737005076 uridine monophosphate binding site [chemical binding]; other site 698737005077 homohexameric interface [polypeptide binding]; other site 698737005078 elongation factor Ts; Provisional; Region: tsf; PRK09377 698737005079 UBA/TS-N domain; Region: UBA; pfam00627 698737005080 Elongation factor TS; Region: EF_TS; pfam00889 698737005081 Elongation factor TS; Region: EF_TS; pfam00889 698737005082 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698737005083 rRNA interaction site [nucleotide binding]; other site 698737005084 S8 interaction site; other site 698737005085 putative laminin-1 binding site; other site 698737005086 transcriptional repressor CodY; Validated; Region: PRK04158 698737005087 CodY GAF-like domain; Region: CodY; pfam06018 698737005088 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 698737005089 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 698737005090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737005091 Walker A motif; other site 698737005092 ATP binding site [chemical binding]; other site 698737005093 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 698737005094 Walker B motif; other site 698737005095 arginine finger; other site 698737005096 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 698737005097 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 698737005098 active site 698737005099 HslU subunit interaction site [polypeptide binding]; other site 698737005100 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698737005101 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698737005102 active site 698737005103 DNA binding site [nucleotide binding] 698737005104 Int/Topo IB signature motif; other site 698737005105 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 698737005106 Glucose inhibited division protein A; Region: GIDA; pfam01134 698737005107 DNA topoisomerase I; Validated; Region: PRK05582 698737005108 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698737005109 active site 698737005110 interdomain interaction site; other site 698737005111 putative metal-binding site [ion binding]; other site 698737005112 nucleotide binding site [chemical binding]; other site 698737005113 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698737005114 domain I; other site 698737005115 DNA binding groove [nucleotide binding] 698737005116 phosphate binding site [ion binding]; other site 698737005117 domain II; other site 698737005118 domain III; other site 698737005119 nucleotide binding site [chemical binding]; other site 698737005120 catalytic site [active] 698737005121 domain IV; other site 698737005122 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 698737005123 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 698737005124 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 698737005125 DNA protecting protein DprA; Region: dprA; TIGR00732 698737005126 FemAB family; Region: FemAB; pfam02388 698737005127 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 698737005128 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698737005129 CHAP domain; Region: CHAP; pfam05257 698737005130 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 698737005131 CoA binding domain; Region: CoA_binding; pfam02629 698737005132 CoA-ligase; Region: Ligase_CoA; pfam00549 698737005133 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 698737005134 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 698737005135 CoA-ligase; Region: Ligase_CoA; pfam00549 698737005136 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698737005137 RNA/DNA hybrid binding site [nucleotide binding]; other site 698737005138 active site 698737005139 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 698737005140 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 698737005141 GTP/Mg2+ binding site [chemical binding]; other site 698737005142 G4 box; other site 698737005143 G5 box; other site 698737005144 G1 box; other site 698737005145 Switch I region; other site 698737005146 G2 box; other site 698737005147 G3 box; other site 698737005148 Switch II region; other site 698737005149 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 698737005150 Predicted membrane protein [Function unknown]; Region: COG4485 698737005151 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 698737005152 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 698737005153 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698737005154 RimM N-terminal domain; Region: RimM; pfam01782 698737005155 PRC-barrel domain; Region: PRC; pfam05239 698737005156 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 698737005157 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 698737005158 beta-lactamase TEM; Provisional; Region: PRK15442 698737005159 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 698737005160 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 698737005161 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 698737005162 Predicted transcriptional regulator [Transcription]; Region: COG3682 698737005163 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698737005164 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698737005165 catalytic residues [active] 698737005166 catalytic nucleophile [active] 698737005167 Presynaptic Site I dimer interface [polypeptide binding]; other site 698737005168 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698737005169 Synaptic Flat tetramer interface [polypeptide binding]; other site 698737005170 Synaptic Site I dimer interface [polypeptide binding]; other site 698737005171 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698737005172 DNA-binding interface [nucleotide binding]; DNA binding site 698737005173 Helix-turn-helix domain; Region: HTH_28; pfam13518 698737005174 Homeodomain-like domain; Region: HTH_32; pfam13565 698737005175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698737005176 Integrase core domain; Region: rve; pfam00665 698737005177 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 698737005178 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 698737005179 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 698737005180 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 698737005181 dimer interface [polypeptide binding]; other site 698737005182 active site 698737005183 acyl-CoA synthetase; Validated; Region: PRK07638 698737005184 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698737005185 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 698737005186 acyl-activating enzyme (AAE) consensus motif; other site 698737005187 acyl-activating enzyme (AAE) consensus motif; other site 698737005188 AMP binding site [chemical binding]; other site 698737005189 active site 698737005190 CoA binding site [chemical binding]; other site 698737005191 signal recognition particle protein; Provisional; Region: PRK10867 698737005192 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 698737005193 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698737005194 P loop; other site 698737005195 GTP binding site [chemical binding]; other site 698737005196 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698737005197 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 698737005198 putative DNA-binding protein; Validated; Region: PRK00118 698737005199 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698737005200 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 698737005201 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698737005202 P loop; other site 698737005203 GTP binding site [chemical binding]; other site 698737005204 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 698737005205 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698737005206 Walker A/P-loop; other site 698737005207 ATP binding site [chemical binding]; other site 698737005208 Q-loop/lid; other site 698737005209 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 698737005210 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 698737005211 ABC transporter signature motif; other site 698737005212 Walker B; other site 698737005213 D-loop; other site 698737005214 H-loop/switch region; other site 698737005215 ribonuclease III; Reviewed; Region: rnc; PRK00102 698737005216 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698737005217 dimerization interface [polypeptide binding]; other site 698737005218 active site 698737005219 metal binding site [ion binding]; metal-binding site 698737005220 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698737005221 dsRNA binding site [nucleotide binding]; other site 698737005222 acyl carrier protein; Provisional; Region: acpP; PRK00982 698737005223 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698737005224 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 698737005225 NAD(P) binding site [chemical binding]; other site 698737005226 homotetramer interface [polypeptide binding]; other site 698737005227 homodimer interface [polypeptide binding]; other site 698737005228 active site 698737005229 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 698737005230 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698737005231 putative phosphate acyltransferase; Provisional; Region: PRK05331 698737005232 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 698737005233 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 698737005234 active site 2 [active] 698737005235 active site 1 [active] 698737005236 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698737005237 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698737005238 generic binding surface II; other site 698737005239 ssDNA binding site; other site 698737005240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737005241 ATP binding site [chemical binding]; other site 698737005242 putative Mg++ binding site [ion binding]; other site 698737005243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737005244 nucleotide binding region [chemical binding]; other site 698737005245 ATP-binding site [chemical binding]; other site 698737005246 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698737005247 DAK2 domain; Region: Dak2; pfam02734 698737005248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 698737005249 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 698737005250 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 698737005251 Thiamine pyrophosphokinase; Region: TPK; cd07995 698737005252 active site 698737005253 dimerization interface [polypeptide binding]; other site 698737005254 thiamine binding site [chemical binding]; other site 698737005255 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 698737005256 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698737005257 substrate binding site [chemical binding]; other site 698737005258 hexamer interface [polypeptide binding]; other site 698737005259 metal binding site [ion binding]; metal-binding site 698737005260 GTPase RsgA; Reviewed; Region: PRK00098 698737005261 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 698737005262 RNA binding site [nucleotide binding]; other site 698737005263 homodimer interface [polypeptide binding]; other site 698737005264 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698737005265 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698737005266 GTP/Mg2+ binding site [chemical binding]; other site 698737005267 G4 box; other site 698737005268 G5 box; other site 698737005269 G1 box; other site 698737005270 Switch I region; other site 698737005271 G2 box; other site 698737005272 G3 box; other site 698737005273 Switch II region; other site 698737005274 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698737005275 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698737005276 active site 698737005277 ATP binding site [chemical binding]; other site 698737005278 substrate binding site [chemical binding]; other site 698737005279 activation loop (A-loop); other site 698737005280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698737005281 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698737005282 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698737005283 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698737005284 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698737005285 Protein phosphatase 2C; Region: PP2C; pfam00481 698737005286 active site 698737005287 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 698737005288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737005289 FeS/SAM binding site; other site 698737005290 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698737005291 NusB family; Region: NusB; pfam01029 698737005292 putative RNA binding site [nucleotide binding]; other site 698737005293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737005294 S-adenosylmethionine binding site [chemical binding]; other site 698737005295 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698737005296 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698737005297 putative active site [active] 698737005298 substrate binding site [chemical binding]; other site 698737005299 putative cosubstrate binding site; other site 698737005300 catalytic site [active] 698737005301 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698737005302 substrate binding site [chemical binding]; other site 698737005303 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698737005304 active site 698737005305 catalytic residues [active] 698737005306 metal binding site [ion binding]; metal-binding site 698737005307 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 698737005308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737005309 ATP binding site [chemical binding]; other site 698737005310 putative Mg++ binding site [ion binding]; other site 698737005311 helicase superfamily c-terminal domain; Region: HELICc; smart00490 698737005312 nucleotide binding region [chemical binding]; other site 698737005313 ATP-binding site [chemical binding]; other site 698737005314 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698737005315 Flavoprotein; Region: Flavoprotein; pfam02441 698737005316 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 698737005317 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 698737005318 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698737005319 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698737005320 catalytic site [active] 698737005321 G-X2-G-X-G-K; other site 698737005322 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 698737005323 Domain of unknown function (DUF814); Region: DUF814; pfam05670 698737005324 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 698737005325 dimer interface [polypeptide binding]; other site 698737005326 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737005327 active site 698737005328 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 698737005329 active site 698737005330 dimer interface [polypeptide binding]; other site 698737005331 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698737005332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737005333 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698737005334 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698737005335 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737005336 ATP-grasp domain; Region: ATP-grasp_4; cl17255 698737005337 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698737005338 IMP binding site; other site 698737005339 dimer interface [polypeptide binding]; other site 698737005340 interdomain contacts; other site 698737005341 partial ornithine binding site; other site 698737005342 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698737005343 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 698737005344 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698737005345 catalytic site [active] 698737005346 subunit interface [polypeptide binding]; other site 698737005347 dihydroorotase; Validated; Region: pyrC; PRK09357 698737005348 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698737005349 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698737005350 active site 698737005351 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698737005352 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698737005353 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 698737005354 uracil transporter; Provisional; Region: PRK10720 698737005355 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 698737005356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737005357 active site 698737005358 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698737005359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737005360 RNA binding surface [nucleotide binding]; other site 698737005361 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698737005362 active site 698737005363 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 698737005364 lipoprotein signal peptidase; Provisional; Region: PRK14787 698737005365 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 698737005366 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737005367 active site 698737005368 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 698737005369 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698737005370 HIGH motif; other site 698737005371 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698737005372 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698737005373 active site 698737005374 KMSKS motif; other site 698737005375 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 698737005376 tRNA binding surface [nucleotide binding]; other site 698737005377 anticodon binding site; other site 698737005378 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698737005379 DivIVA protein; Region: DivIVA; pfam05103 698737005380 DivIVA domain; Region: DivI1A_domain; TIGR03544 698737005381 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 698737005382 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737005383 RNA binding surface [nucleotide binding]; other site 698737005384 YGGT family; Region: YGGT; pfam02325 698737005385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 698737005386 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 698737005387 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698737005388 catalytic residue [active] 698737005389 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698737005390 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 698737005391 cell division protein FtsZ; Validated; Region: PRK09330 698737005392 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698737005393 nucleotide binding site [chemical binding]; other site 698737005394 SulA interaction site; other site 698737005395 cell division protein FtsA; Region: ftsA; TIGR01174 698737005396 Cell division protein FtsA; Region: FtsA; smart00842 698737005397 Cell division protein FtsA; Region: FtsA; pfam14450 698737005398 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698737005399 Cell division protein FtsQ; Region: FtsQ; pfam03799 698737005400 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 698737005401 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 698737005402 NAD binding site [chemical binding]; other site 698737005403 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737005404 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737005405 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698737005406 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698737005407 Mg++ binding site [ion binding]; other site 698737005408 putative catalytic motif [active] 698737005409 putative substrate binding site [chemical binding]; other site 698737005410 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698737005411 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698737005412 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 698737005413 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 698737005414 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 698737005415 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 698737005416 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 698737005417 MraW methylase family; Region: Methyltransf_5; pfam01795 698737005418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 698737005419 MraZ protein; Region: MraZ; pfam02381 698737005420 MraZ protein; Region: MraZ; pfam02381 698737005421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 698737005422 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 698737005423 hypothetical protein; Provisional; Region: PRK13688 698737005424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737005425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698737005426 Coenzyme A binding pocket [chemical binding]; other site 698737005427 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 698737005428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737005429 motif II; other site 698737005430 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 698737005431 active site 698737005432 metal binding site [ion binding]; metal-binding site 698737005433 homotetramer interface [polypeptide binding]; other site 698737005434 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698737005435 active site 698737005436 dimerization interface [polypeptide binding]; other site 698737005437 glutamate racemase; Provisional; Region: PRK00865 698737005438 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 698737005439 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 698737005440 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 698737005441 L-aspartate oxidase; Provisional; Region: PRK06175 698737005442 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698737005443 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 698737005444 putative Iron-sulfur protein interface [polypeptide binding]; other site 698737005445 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698737005446 proximal heme binding site [chemical binding]; other site 698737005447 distal heme binding site [chemical binding]; other site 698737005448 putative dimer interface [polypeptide binding]; other site 698737005449 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698737005450 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698737005451 GIY-YIG motif/motif A; other site 698737005452 active site 698737005453 catalytic site [active] 698737005454 putative DNA binding site [nucleotide binding]; other site 698737005455 metal binding site [ion binding]; metal-binding site 698737005456 UvrB/uvrC motif; Region: UVR; pfam02151 698737005457 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698737005458 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737005459 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 698737005460 catalytic residues [active] 698737005461 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 698737005462 MutS domain III; Region: MutS_III; pfam05192 698737005463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737005464 Walker A/P-loop; other site 698737005465 ATP binding site [chemical binding]; other site 698737005466 Q-loop/lid; other site 698737005467 ABC transporter signature motif; other site 698737005468 Walker B; other site 698737005469 D-loop; other site 698737005470 H-loop/switch region; other site 698737005471 Smr domain; Region: Smr; pfam01713 698737005472 hypothetical protein; Provisional; Region: PRK08609 698737005473 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 698737005474 active site 698737005475 primer binding site [nucleotide binding]; other site 698737005476 NTP binding site [chemical binding]; other site 698737005477 metal binding triad [ion binding]; metal-binding site 698737005478 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 698737005479 active site 698737005480 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 698737005481 Colicin V production protein; Region: Colicin_V; pfam02674 698737005482 Cell division protein ZapA; Region: ZapA; cl01146 698737005483 ribonuclease HIII; Provisional; Region: PRK00996 698737005484 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 698737005485 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 698737005486 RNA/DNA hybrid binding site [nucleotide binding]; other site 698737005487 active site 698737005488 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698737005489 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698737005490 putative tRNA-binding site [nucleotide binding]; other site 698737005491 B3/4 domain; Region: B3_4; pfam03483 698737005492 tRNA synthetase B5 domain; Region: B5; smart00874 698737005493 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698737005494 dimer interface [polypeptide binding]; other site 698737005495 motif 1; other site 698737005496 motif 3; other site 698737005497 motif 2; other site 698737005498 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 698737005499 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698737005500 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698737005501 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698737005502 dimer interface [polypeptide binding]; other site 698737005503 motif 1; other site 698737005504 active site 698737005505 motif 2; other site 698737005506 motif 3; other site 698737005507 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698737005508 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698737005509 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698737005510 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 698737005511 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 698737005512 hypothetical protein; Provisional; Region: PRK13670 698737005513 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 698737005514 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698737005515 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698737005516 active site 698737005517 (T/H)XGH motif; other site 698737005518 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 698737005519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737005520 S-adenosylmethionine binding site [chemical binding]; other site 698737005521 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 698737005522 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698737005523 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 698737005524 putative active site [active] 698737005525 catalytic site [active] 698737005526 putative metal binding site [ion binding]; other site 698737005527 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 698737005528 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 698737005529 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 698737005530 Protein of unknown function (DUF420); Region: DUF420; pfam04238 698737005531 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 698737005532 UbiA prenyltransferase family; Region: UbiA; pfam01040 698737005533 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 698737005534 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698737005535 pyruvate carboxylase; Reviewed; Region: PRK12999 698737005536 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698737005537 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 698737005538 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 698737005539 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698737005540 active site 698737005541 catalytic residues [active] 698737005542 metal binding site [ion binding]; metal-binding site 698737005543 homodimer binding site [polypeptide binding]; other site 698737005544 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698737005545 carboxyltransferase (CT) interaction site; other site 698737005546 biotinylation site [posttranslational modification]; other site 698737005547 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 698737005548 hypothetical protein; Provisional; Region: PRK13666 698737005549 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 698737005550 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 698737005551 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 698737005552 G1 box; other site 698737005553 putative GEF interaction site [polypeptide binding]; other site 698737005554 GTP/Mg2+ binding site [chemical binding]; other site 698737005555 Switch I region; other site 698737005556 G2 box; other site 698737005557 G3 box; other site 698737005558 Switch II region; other site 698737005559 G4 box; other site 698737005560 G5 box; other site 698737005561 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698737005562 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698737005563 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 698737005564 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698737005565 active site 698737005566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 698737005567 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 698737005568 manganese transport protein MntH; Reviewed; Region: PRK00701 698737005569 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 698737005570 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 698737005571 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698737005572 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 698737005573 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 698737005574 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 698737005575 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 698737005576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737005577 dimer interface [polypeptide binding]; other site 698737005578 conserved gate region; other site 698737005579 putative PBP binding loops; other site 698737005580 ABC-ATPase subunit interface; other site 698737005581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737005582 dimer interface [polypeptide binding]; other site 698737005583 conserved gate region; other site 698737005584 putative PBP binding loops; other site 698737005585 ABC-ATPase subunit interface; other site 698737005586 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698737005587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737005588 Walker A/P-loop; other site 698737005589 ATP binding site [chemical binding]; other site 698737005590 Q-loop/lid; other site 698737005591 ABC transporter signature motif; other site 698737005592 Walker B; other site 698737005593 D-loop; other site 698737005594 H-loop/switch region; other site 698737005595 TOBE domain; Region: TOBE_2; pfam08402 698737005596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737005597 sequence-specific DNA binding site [nucleotide binding]; other site 698737005598 salt bridge; other site 698737005599 Cupin domain; Region: Cupin_2; pfam07883 698737005600 hypothetical protein; Provisional; Region: PRK04387 698737005601 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 698737005602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698737005603 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737005604 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737005605 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 698737005606 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698737005607 E3 interaction surface; other site 698737005608 lipoyl attachment site [posttranslational modification]; other site 698737005609 e3 binding domain; Region: E3_binding; pfam02817 698737005610 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 698737005611 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 698737005612 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 698737005613 alpha subunit interface [polypeptide binding]; other site 698737005614 TPP binding site [chemical binding]; other site 698737005615 heterodimer interface [polypeptide binding]; other site 698737005616 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698737005617 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 698737005618 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 698737005619 TPP-binding site [chemical binding]; other site 698737005620 tetramer interface [polypeptide binding]; other site 698737005621 heterodimer interface [polypeptide binding]; other site 698737005622 phosphorylation loop region [posttranslational modification] 698737005623 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 698737005624 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698737005625 active site 698737005626 catalytic residues [active] 698737005627 metal binding site [ion binding]; metal-binding site 698737005628 hypothetical protein; Provisional; Region: PRK13667 698737005629 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698737005630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 698737005631 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698737005632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 698737005633 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698737005634 TrkA-N domain; Region: TrkA_N; pfam02254 698737005635 TrkA-C domain; Region: TrkA_C; pfam02080 698737005636 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 698737005637 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698737005638 catalytic residues [active] 698737005639 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698737005640 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698737005641 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 698737005642 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 698737005643 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698737005644 dimerization domain swap beta strand [polypeptide binding]; other site 698737005645 regulatory protein interface [polypeptide binding]; other site 698737005646 active site 698737005647 regulatory phosphorylation site [posttranslational modification]; other site 698737005648 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 698737005649 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 698737005650 putative RNA binding site [nucleotide binding]; other site 698737005651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737005652 S-adenosylmethionine binding site [chemical binding]; other site 698737005653 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 698737005654 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737005655 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698737005656 Walker A/P-loop; other site 698737005657 ATP binding site [chemical binding]; other site 698737005658 Q-loop/lid; other site 698737005659 ABC transporter signature motif; other site 698737005660 Walker B; other site 698737005661 D-loop; other site 698737005662 H-loop/switch region; other site 698737005663 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698737005664 Walker A/P-loop; other site 698737005665 ATP binding site [chemical binding]; other site 698737005666 ABC transporter; Region: ABC_tran; pfam00005 698737005667 Q-loop/lid; other site 698737005668 ABC transporter signature motif; other site 698737005669 Walker B; other site 698737005670 D-loop; other site 698737005671 H-loop/switch region; other site 698737005672 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698737005673 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698737005674 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 698737005675 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 698737005676 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698737005677 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698737005678 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698737005679 purine monophosphate binding site [chemical binding]; other site 698737005680 dimer interface [polypeptide binding]; other site 698737005681 putative catalytic residues [active] 698737005682 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 698737005683 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 698737005684 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 698737005685 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698737005686 active site 698737005687 substrate binding site [chemical binding]; other site 698737005688 cosubstrate binding site; other site 698737005689 catalytic site [active] 698737005690 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698737005691 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698737005692 dimerization interface [polypeptide binding]; other site 698737005693 putative ATP binding site [chemical binding]; other site 698737005694 amidophosphoribosyltransferase; Provisional; Region: PRK07272 698737005695 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698737005696 active site 698737005697 tetramer interface [polypeptide binding]; other site 698737005698 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737005699 active site 698737005700 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 698737005701 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 698737005702 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698737005703 dimerization interface [polypeptide binding]; other site 698737005704 ATP binding site [chemical binding]; other site 698737005705 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698737005706 dimerization interface [polypeptide binding]; other site 698737005707 ATP binding site [chemical binding]; other site 698737005708 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 698737005709 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698737005710 putative active site [active] 698737005711 catalytic triad [active] 698737005712 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 698737005713 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698737005714 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 698737005715 ATP binding site [chemical binding]; other site 698737005716 active site 698737005717 substrate binding site [chemical binding]; other site 698737005718 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 698737005719 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698737005720 ATP-grasp domain; Region: ATP-grasp; pfam02222 698737005721 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 698737005722 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 698737005723 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698737005724 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698737005725 homodimer interface [polypeptide binding]; other site 698737005726 NADP binding site [chemical binding]; other site 698737005727 substrate binding site [chemical binding]; other site 698737005728 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 698737005729 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 698737005730 heme-binding site [chemical binding]; other site 698737005731 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 698737005732 FAD binding pocket [chemical binding]; other site 698737005733 conserved FAD binding motif [chemical binding]; other site 698737005734 phosphate binding motif [ion binding]; other site 698737005735 beta-alpha-beta structure motif; other site 698737005736 NAD binding pocket [chemical binding]; other site 698737005737 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 698737005738 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 698737005739 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 698737005740 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 698737005741 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 698737005742 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698737005743 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698737005744 D-pathway; other site 698737005745 Putative ubiquinol binding site [chemical binding]; other site 698737005746 Low-spin heme (heme b) binding site [chemical binding]; other site 698737005747 Putative water exit pathway; other site 698737005748 Binuclear center (heme o3/CuB) [ion binding]; other site 698737005749 K-pathway; other site 698737005750 Putative proton exit pathway; other site 698737005751 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 698737005752 Subunit I/III interface [polypeptide binding]; other site 698737005753 Subunit III/IV interface [polypeptide binding]; other site 698737005754 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 698737005755 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698737005756 active site 698737005757 tetramer interface [polypeptide binding]; other site 698737005758 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 698737005759 Beta-lactamase; Region: Beta-lactamase; pfam00144 698737005760 Transcriptional regulator [Transcription]; Region: LytR; COG1316 698737005761 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 698737005762 Autoinducer synthetase; Region: Autoind_synth; cl17404 698737005763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737005764 Coenzyme A binding pocket [chemical binding]; other site 698737005765 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 698737005766 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698737005767 amidase catalytic site [active] 698737005768 Zn binding residues [ion binding]; other site 698737005769 substrate binding site [chemical binding]; other site 698737005770 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 698737005771 Lysozyme subfamily 2; Region: LYZ2; smart00047 698737005772 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737005773 MarR family; Region: MarR; pfam01047 698737005774 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 698737005775 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698737005776 aminotransferase A; Validated; Region: PRK07683 698737005777 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737005778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737005779 homodimer interface [polypeptide binding]; other site 698737005780 catalytic residue [active] 698737005781 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698737005782 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698737005783 substrate binding site [chemical binding]; other site 698737005784 oxyanion hole (OAH) forming residues; other site 698737005785 trimer interface [polypeptide binding]; other site 698737005786 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 698737005787 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 698737005788 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698737005789 dimer interface [polypeptide binding]; other site 698737005790 tetramer interface [polypeptide binding]; other site 698737005791 PYR/PP interface [polypeptide binding]; other site 698737005792 TPP binding site [chemical binding]; other site 698737005793 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698737005794 TPP-binding site; other site 698737005795 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 698737005796 isochorismate synthases; Region: isochor_syn; TIGR00543 698737005797 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 698737005798 UbiA prenyltransferase family; Region: UbiA; pfam01040 698737005799 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 698737005800 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 698737005801 ComK protein; Region: ComK; cl11560 698737005802 IDEAL domain; Region: IDEAL; pfam08858 698737005803 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 698737005804 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 698737005805 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 698737005806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 698737005807 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 698737005808 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698737005809 active site 698737005810 metal binding site [ion binding]; metal-binding site 698737005811 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698737005812 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 698737005813 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698737005814 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 698737005815 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 698737005816 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698737005817 protein binding site [polypeptide binding]; other site 698737005818 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 698737005819 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 698737005820 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698737005821 G1 box; other site 698737005822 putative GEF interaction site [polypeptide binding]; other site 698737005823 GTP/Mg2+ binding site [chemical binding]; other site 698737005824 Switch I region; other site 698737005825 G2 box; other site 698737005826 G3 box; other site 698737005827 Switch II region; other site 698737005828 G4 box; other site 698737005829 G5 box; other site 698737005830 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 698737005831 YueH-like protein; Region: YueH; pfam14166 698737005832 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 698737005833 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698737005834 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698737005835 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698737005836 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 698737005837 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 698737005838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698737005839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737005840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737005841 putative substrate translocation pore; other site 698737005842 hypothetical protein; Provisional; Region: PRK13679 698737005843 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 698737005844 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 698737005845 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698737005846 DNA binding residues [nucleotide binding] 698737005847 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698737005848 classical (c) SDRs; Region: SDR_c; cd05233 698737005849 NAD(P) binding site [chemical binding]; other site 698737005850 active site 698737005851 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 698737005852 Putative esterase; Region: Esterase; pfam00756 698737005853 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698737005854 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698737005855 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 698737005856 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 698737005857 NAD binding site [chemical binding]; other site 698737005858 homotetramer interface [polypeptide binding]; other site 698737005859 homodimer interface [polypeptide binding]; other site 698737005860 substrate binding site [chemical binding]; other site 698737005861 active site 698737005862 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 698737005863 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698737005864 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698737005865 TrkA-N domain; Region: TrkA_N; pfam02254 698737005866 TrkA-C domain; Region: TrkA_C; pfam02080 698737005867 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698737005868 MgtE intracellular N domain; Region: MgtE_N; pfam03448 698737005869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698737005870 Divalent cation transporter; Region: MgtE; pfam01769 698737005871 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 698737005872 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737005873 RNA binding surface [nucleotide binding]; other site 698737005874 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698737005875 active site 698737005876 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 698737005877 ATP-NAD kinase; Region: NAD_kinase; pfam01513 698737005878 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698737005879 synthetase active site [active] 698737005880 NTP binding site [chemical binding]; other site 698737005881 metal binding site [ion binding]; metal-binding site 698737005882 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 698737005883 putative active site [active] 698737005884 putative metal binding residues [ion binding]; other site 698737005885 signature motif; other site 698737005886 putative triphosphate binding site [ion binding]; other site 698737005887 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698737005888 apolar tunnel; other site 698737005889 heme binding site [chemical binding]; other site 698737005890 dimerization interface [polypeptide binding]; other site 698737005891 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 698737005892 Thioredoxin; Region: Thioredoxin_5; pfam13743 698737005893 oligoendopeptidase F; Region: pepF; TIGR00181 698737005894 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 698737005895 active site 698737005896 Zn binding site [ion binding]; other site 698737005897 Competence protein CoiA-like family; Region: CoiA; pfam06054 698737005898 adaptor protein; Provisional; Region: PRK02315 698737005899 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 698737005900 ArsC family; Region: ArsC; pfam03960 698737005901 putative catalytic residues [active] 698737005902 thiol/disulfide switch; other site 698737005903 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698737005904 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698737005905 active site 698737005906 HIGH motif; other site 698737005907 dimer interface [polypeptide binding]; other site 698737005908 KMSKS motif; other site 698737005909 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698737005910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737005911 S-adenosylmethionine binding site [chemical binding]; other site 698737005912 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 698737005913 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 698737005914 peptide binding site [polypeptide binding]; other site 698737005915 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698737005916 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698737005917 Walker A/P-loop; other site 698737005918 ATP binding site [chemical binding]; other site 698737005919 Q-loop/lid; other site 698737005920 ABC transporter signature motif; other site 698737005921 Walker B; other site 698737005922 D-loop; other site 698737005923 H-loop/switch region; other site 698737005924 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698737005925 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698737005926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 698737005927 Walker A/P-loop; other site 698737005928 ATP binding site [chemical binding]; other site 698737005929 Q-loop/lid; other site 698737005930 ABC transporter signature motif; other site 698737005931 Walker B; other site 698737005932 D-loop; other site 698737005933 H-loop/switch region; other site 698737005934 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698737005935 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 698737005936 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 698737005937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737005938 dimer interface [polypeptide binding]; other site 698737005939 conserved gate region; other site 698737005940 putative PBP binding loops; other site 698737005941 ABC-ATPase subunit interface; other site 698737005942 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698737005943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737005944 dimer interface [polypeptide binding]; other site 698737005945 ABC-ATPase subunit interface; other site 698737005946 putative PBP binding loops; other site 698737005947 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 698737005948 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 698737005949 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 698737005950 dimer interface [polypeptide binding]; other site 698737005951 active site 698737005952 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 698737005953 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698737005954 dimer interface [polypeptide binding]; other site 698737005955 active site 698737005956 CoA binding pocket [chemical binding]; other site 698737005957 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 698737005958 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698737005959 Clp amino terminal domain; Region: Clp_N; pfam02861 698737005960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737005961 Walker A motif; other site 698737005962 ATP binding site [chemical binding]; other site 698737005963 Walker B motif; other site 698737005964 arginine finger; other site 698737005965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737005966 Walker A motif; other site 698737005967 ATP binding site [chemical binding]; other site 698737005968 Walker B motif; other site 698737005969 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698737005970 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 698737005971 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737005972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737005973 motif II; other site 698737005974 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 698737005975 coenzyme A disulfide reductase; Provisional; Region: PRK13512 698737005976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737005977 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737005978 hypothetical protein; Provisional; Region: PRK13673 698737005979 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 698737005980 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 698737005981 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 698737005982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 698737005983 Family description; Region: UvrD_C_2; pfam13538 698737005984 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698737005985 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 698737005986 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 698737005987 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698737005988 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698737005989 Catalytic site [active] 698737005990 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698737005991 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698737005992 Uncharacterized conserved protein [Function unknown]; Region: COG0398 698737005993 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 698737005994 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 698737005995 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 698737005996 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698737005997 active site 698737005998 dimer interface [polypeptide binding]; other site 698737005999 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698737006000 dimer interface [polypeptide binding]; other site 698737006001 active site 698737006002 argininosuccinate synthase; Provisional; Region: PRK13820 698737006003 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698737006004 ANP binding site [chemical binding]; other site 698737006005 Substrate Binding Site II [chemical binding]; other site 698737006006 Substrate Binding Site I [chemical binding]; other site 698737006007 argininosuccinate lyase; Provisional; Region: PRK00855 698737006008 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698737006009 active sites [active] 698737006010 tetramer interface [polypeptide binding]; other site 698737006011 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 698737006012 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698737006013 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 698737006014 NAD(P) binding site [chemical binding]; other site 698737006015 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 698737006016 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 698737006017 putative active site [active] 698737006018 putative FMN binding site [chemical binding]; other site 698737006019 putative substrate binding site [chemical binding]; other site 698737006020 putative catalytic residue [active] 698737006021 general stress protein 13; Validated; Region: PRK08059 698737006022 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698737006023 RNA binding site [nucleotide binding]; other site 698737006024 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 698737006025 active site 698737006026 Kinase associated protein B; Region: KapB; pfam08810 698737006027 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 698737006028 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698737006029 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698737006030 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698737006031 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 698737006032 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 698737006033 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 698737006034 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698737006035 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 698737006036 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 698737006037 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 698737006038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698737006039 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 698737006040 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698737006041 CoenzymeA binding site [chemical binding]; other site 698737006042 subunit interaction site [polypeptide binding]; other site 698737006043 PHB binding site; other site 698737006044 Predicted permease [General function prediction only]; Region: COG2056 698737006045 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 698737006046 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 698737006047 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 698737006048 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698737006049 interface (dimer of trimers) [polypeptide binding]; other site 698737006050 Substrate-binding/catalytic site; other site 698737006051 Zn-binding sites [ion binding]; other site 698737006052 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698737006053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737006054 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 698737006055 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737006056 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698737006057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737006058 Walker A/P-loop; other site 698737006059 ATP binding site [chemical binding]; other site 698737006060 Q-loop/lid; other site 698737006061 ABC transporter signature motif; other site 698737006062 Walker B; other site 698737006063 D-loop; other site 698737006064 H-loop/switch region; other site 698737006065 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737006066 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698737006067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737006068 Walker A/P-loop; other site 698737006069 ATP binding site [chemical binding]; other site 698737006070 Q-loop/lid; other site 698737006071 ABC transporter signature motif; other site 698737006072 Walker B; other site 698737006073 D-loop; other site 698737006074 H-loop/switch region; other site 698737006075 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737006076 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 698737006077 Walker A/P-loop; other site 698737006078 ATP binding site [chemical binding]; other site 698737006079 Q-loop/lid; other site 698737006080 ABC transporter signature motif; other site 698737006081 Walker B; other site 698737006082 D-loop; other site 698737006083 H-loop/switch region; other site 698737006084 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737006085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737006086 Walker A/P-loop; other site 698737006087 ATP binding site [chemical binding]; other site 698737006088 Q-loop/lid; other site 698737006089 ABC transporter signature motif; other site 698737006090 Walker B; other site 698737006091 D-loop; other site 698737006092 H-loop/switch region; other site 698737006093 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 698737006094 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 698737006095 Condensation domain; Region: Condensation; pfam00668 698737006096 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737006097 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698737006098 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737006099 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 698737006100 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 698737006101 Methyltransferase domain; Region: Methyltransf_12; pfam08242 698737006102 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698737006103 Condensation domain; Region: Condensation; pfam00668 698737006104 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737006105 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698737006106 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 698737006107 acyl-activating enzyme (AAE) consensus motif; other site 698737006108 AMP binding site [chemical binding]; other site 698737006109 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 698737006110 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737006111 Condensation domain; Region: Condensation; pfam00668 698737006112 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698737006113 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698737006114 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 698737006115 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 698737006116 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 698737006117 acyl-activating enzyme (AAE) consensus motif; other site 698737006118 active site 698737006119 AMP binding site [chemical binding]; other site 698737006120 substrate binding site [chemical binding]; other site 698737006121 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 698737006122 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 698737006123 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 698737006124 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 698737006125 hypothetical protein; Provisional; Region: PRK13669 698737006126 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698737006127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737006128 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 698737006129 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 698737006130 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 698737006131 DltD N-terminal region; Region: DltD_N; pfam04915 698737006132 DltD central region; Region: DltD_M; pfam04918 698737006133 DltD C-terminal region; Region: DltD_C; pfam04914 698737006134 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 698737006135 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 698737006136 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 698737006137 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 698737006138 acyl-activating enzyme (AAE) consensus motif; other site 698737006139 AMP binding site [chemical binding]; other site 698737006140 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 698737006141 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 698737006142 dimerization interface [polypeptide binding]; other site 698737006143 ligand binding site [chemical binding]; other site 698737006144 NADP binding site [chemical binding]; other site 698737006145 catalytic site [active] 698737006146 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698737006147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737006148 active site 698737006149 motif I; other site 698737006150 motif II; other site 698737006151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737006152 Uncharacterized conserved protein [Function unknown]; Region: COG2445 698737006153 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 698737006154 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 698737006155 lipoyl synthase; Provisional; Region: PRK05481 698737006156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698737006157 FeS/SAM binding site; other site 698737006158 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 698737006159 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 698737006160 active site 698737006161 metal binding site [ion binding]; metal-binding site 698737006162 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 698737006163 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 698737006164 Uncharacterized conserved protein [Function unknown]; Region: COG1801 698737006165 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 698737006166 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698737006167 FMN binding site [chemical binding]; other site 698737006168 substrate binding site [chemical binding]; other site 698737006169 putative catalytic residue [active] 698737006170 Domain of unknown function DUF21; Region: DUF21; pfam01595 698737006171 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698737006172 Protein of unknown function, DUF600; Region: DUF600; cl04640 698737006173 Protein of unknown function, DUF600; Region: DUF600; cl04640 698737006174 Protein of unknown function, DUF600; Region: DUF600; cl04640 698737006175 LXG domain of WXG superfamily; Region: LXG; pfam04740 698737006176 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 698737006177 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 698737006178 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698737006179 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 698737006180 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 698737006181 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 698737006182 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 698737006183 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 698737006184 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698737006185 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698737006186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 698737006187 Surface antigen [General function prediction only]; Region: COG3942 698737006188 CHAP domain; Region: CHAP; pfam05257 698737006189 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 698737006190 FeS assembly protein SufB; Region: sufB; TIGR01980 698737006191 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698737006192 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698737006193 trimerization site [polypeptide binding]; other site 698737006194 active site 698737006195 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698737006196 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698737006197 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737006198 catalytic residue [active] 698737006199 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698737006200 FeS assembly protein SufD; Region: sufD; TIGR01981 698737006201 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 698737006202 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 698737006203 Walker A/P-loop; other site 698737006204 ATP binding site [chemical binding]; other site 698737006205 Q-loop/lid; other site 698737006206 ABC transporter signature motif; other site 698737006207 Walker B; other site 698737006208 D-loop; other site 698737006209 H-loop/switch region; other site 698737006210 Predicted membrane protein [Function unknown]; Region: COG2035 698737006211 CsbD-like; Region: CsbD; pfam05532 698737006212 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737006213 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698737006214 intersubunit interface [polypeptide binding]; other site 698737006215 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 698737006216 Preprotein binding site; other site 698737006217 SecA binding site; other site 698737006218 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737006219 putative DNA binding site [nucleotide binding]; other site 698737006220 putative Zn2+ binding site [ion binding]; other site 698737006221 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 698737006222 Cadmium resistance transporter; Region: Cad; pfam03596 698737006223 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 698737006224 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 698737006225 Virulence-associated protein E; Region: VirE; pfam05272 698737006226 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 698737006227 Protein of unknown function (DUF1474); Region: DUF1474; pfam07342 698737006228 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 698737006229 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737006230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737006231 non-specific DNA binding site [nucleotide binding]; other site 698737006232 salt bridge; other site 698737006233 sequence-specific DNA binding site [nucleotide binding]; other site 698737006234 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737006235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737006236 non-specific DNA binding site [nucleotide binding]; other site 698737006237 salt bridge; other site 698737006238 sequence-specific DNA binding site [nucleotide binding]; other site 698737006239 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 698737006240 Int/Topo IB signature motif; other site 698737006241 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698737006242 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698737006243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737006244 dimer interface [polypeptide binding]; other site 698737006245 conserved gate region; other site 698737006246 ABC-ATPase subunit interface; other site 698737006247 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698737006248 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698737006249 Walker A/P-loop; other site 698737006250 ATP binding site [chemical binding]; other site 698737006251 Q-loop/lid; other site 698737006252 ABC transporter signature motif; other site 698737006253 Walker B; other site 698737006254 D-loop; other site 698737006255 H-loop/switch region; other site 698737006256 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 698737006257 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737006258 catalytic residues [active] 698737006259 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 698737006260 putative active site [active] 698737006261 putative metal binding site [ion binding]; other site 698737006262 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 698737006263 lipoyl attachment site [posttranslational modification]; other site 698737006264 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 698737006265 ArsC family; Region: ArsC; pfam03960 698737006266 putative ArsC-like catalytic residues; other site 698737006267 putative TRX-like catalytic residues [active] 698737006268 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698737006269 catalytic residues [active] 698737006270 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 698737006271 putative FMN binding site [chemical binding]; other site 698737006272 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 698737006273 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 698737006274 active site 698737006275 catalytic residue [active] 698737006276 dimer interface [polypeptide binding]; other site 698737006277 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 698737006278 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 698737006279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737006280 Coenzyme A binding pocket [chemical binding]; other site 698737006281 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737006282 catalytic core [active] 698737006283 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 698737006284 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 698737006285 Protein of unknown function (DUF867); Region: DUF867; pfam05908 698737006286 DoxX; Region: DoxX; pfam07681 698737006287 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 698737006288 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 698737006289 active site 698737006290 metal binding site [ion binding]; metal-binding site 698737006291 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 698737006292 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 698737006293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 698737006294 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698737006295 active site 698737006296 metal binding site [ion binding]; metal-binding site 698737006297 Protein of unknown function, DUF576; Region: DUF576; pfam04507 698737006298 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 698737006299 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 698737006300 H+ Antiporter protein; Region: 2A0121; TIGR00900 698737006301 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698737006302 active site residue [active] 698737006303 MarR family; Region: MarR_2; cl17246 698737006304 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737006305 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 698737006306 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698737006307 SmpB-tmRNA interface; other site 698737006308 ribonuclease R; Region: RNase_R; TIGR02063 698737006309 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 698737006310 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 698737006311 RNB domain; Region: RNB; pfam00773 698737006312 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 698737006313 RNA binding site [nucleotide binding]; other site 698737006314 Esterase/lipase [General function prediction only]; Region: COG1647 698737006315 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 698737006316 enolase; Provisional; Region: eno; PRK00077 698737006317 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698737006318 dimer interface [polypeptide binding]; other site 698737006319 metal binding site [ion binding]; metal-binding site 698737006320 substrate binding pocket [chemical binding]; other site 698737006321 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 698737006322 phosphoglyceromutase; Provisional; Region: PRK05434 698737006323 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698737006324 triosephosphate isomerase; Provisional; Region: PRK14565 698737006325 substrate binding site [chemical binding]; other site 698737006326 dimer interface [polypeptide binding]; other site 698737006327 catalytic triad [active] 698737006328 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698737006329 Phosphoglycerate kinase; Region: PGK; pfam00162 698737006330 substrate binding site [chemical binding]; other site 698737006331 hinge regions; other site 698737006332 ADP binding site [chemical binding]; other site 698737006333 catalytic site [active] 698737006334 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 698737006335 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 698737006336 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 698737006337 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698737006338 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698737006339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006340 TIGR01777 family protein; Region: yfcH 698737006341 NAD(P) binding site [chemical binding]; other site 698737006342 active site 698737006343 Clp protease; Region: CLP_protease; pfam00574 698737006344 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698737006345 oligomer interface [polypeptide binding]; other site 698737006346 active site residues [active] 698737006347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698737006348 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698737006349 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 698737006350 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698737006351 phosphate binding site [ion binding]; other site 698737006352 putative substrate binding pocket [chemical binding]; other site 698737006353 dimer interface [polypeptide binding]; other site 698737006354 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 698737006355 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698737006356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698737006357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737006358 TPR repeat; Region: TPR_11; pfam13414 698737006359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 698737006360 binding surface 698737006361 TPR motif; other site 698737006362 putative acyl transferase; Provisional; Region: PRK10191 698737006363 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 698737006364 trimer interface [polypeptide binding]; other site 698737006365 active site 698737006366 substrate binding site [chemical binding]; other site 698737006367 CoA binding site [chemical binding]; other site 698737006368 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 698737006369 HPr kinase/phosphorylase; Provisional; Region: PRK05428 698737006370 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 698737006371 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 698737006372 Hpr binding site; other site 698737006373 active site 698737006374 homohexamer subunit interaction site [polypeptide binding]; other site 698737006375 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698737006376 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698737006377 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 698737006378 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 698737006379 excinuclease ABC subunit B; Provisional; Region: PRK05298 698737006380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737006381 ATP binding site [chemical binding]; other site 698737006382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737006383 nucleotide binding region [chemical binding]; other site 698737006384 ATP-binding site [chemical binding]; other site 698737006385 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698737006386 UvrB/uvrC motif; Region: UVR; pfam02151 698737006387 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 698737006388 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737006389 Zn2+ binding site [ion binding]; other site 698737006390 Mg2+ binding site [ion binding]; other site 698737006391 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 698737006392 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698737006393 Surface antigen [General function prediction only]; Region: COG3942 698737006394 CHAP domain; Region: CHAP; pfam05257 698737006395 peptide chain release factor 2; Provisional; Region: PRK06746 698737006396 This domain is found in peptide chain release factors; Region: PCRF; smart00937 698737006397 RF-1 domain; Region: RF-1; pfam00472 698737006398 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698737006399 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 698737006400 SEC-C motif; Region: SEC-C; pfam02810 698737006401 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698737006402 amidase catalytic site [active] 698737006403 Zn binding residues [ion binding]; other site 698737006404 substrate binding site [chemical binding]; other site 698737006405 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 698737006406 30S subunit binding site; other site 698737006407 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 698737006408 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737006409 active site 698737006410 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698737006411 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737006412 ATP binding site [chemical binding]; other site 698737006413 putative Mg++ binding site [ion binding]; other site 698737006414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737006415 nucleotide binding region [chemical binding]; other site 698737006416 ATP-binding site [chemical binding]; other site 698737006417 EDD domain protein, DegV family; Region: DegV; TIGR00762 698737006418 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 698737006419 Uncharacterized conserved protein [Function unknown]; Region: COG1739 698737006420 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698737006421 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698737006422 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698737006423 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698737006424 Mg++ binding site [ion binding]; other site 698737006425 putative catalytic motif [active] 698737006426 substrate binding site [chemical binding]; other site 698737006427 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 698737006428 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 698737006429 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 698737006430 metal binding site [ion binding]; metal-binding site 698737006431 active site 698737006432 I-site; other site 698737006433 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698737006434 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698737006435 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698737006436 peptidase T; Region: peptidase-T; TIGR01882 698737006437 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 698737006438 metal binding site [ion binding]; metal-binding site 698737006439 dimer interface [polypeptide binding]; other site 698737006440 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 698737006441 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 698737006442 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 698737006443 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 698737006444 FAD binding domain; Region: FAD_binding_4; pfam01565 698737006445 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698737006446 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 698737006447 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 698737006448 putative ligand binding residues [chemical binding]; other site 698737006449 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 698737006450 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737006451 Walker A/P-loop; other site 698737006452 ATP binding site [chemical binding]; other site 698737006453 Q-loop/lid; other site 698737006454 ABC transporter signature motif; other site 698737006455 Walker B; other site 698737006456 D-loop; other site 698737006457 H-loop/switch region; other site 698737006458 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698737006459 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006460 ABC-ATPase subunit interface; other site 698737006461 dimer interface [polypeptide binding]; other site 698737006462 putative PBP binding regions; other site 698737006463 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006464 ABC-ATPase subunit interface; other site 698737006465 dimer interface [polypeptide binding]; other site 698737006466 putative PBP binding regions; other site 698737006467 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 698737006468 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698737006469 intersubunit interface [polypeptide binding]; other site 698737006470 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 698737006471 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737006472 Walker A/P-loop; other site 698737006473 ATP binding site [chemical binding]; other site 698737006474 Q-loop/lid; other site 698737006475 ABC transporter signature motif; other site 698737006476 Walker B; other site 698737006477 D-loop; other site 698737006478 H-loop/switch region; other site 698737006479 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006480 ABC-ATPase subunit interface; other site 698737006481 dimer interface [polypeptide binding]; other site 698737006482 putative PBP binding regions; other site 698737006483 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698737006484 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006485 ABC-ATPase subunit interface; other site 698737006486 dimer interface [polypeptide binding]; other site 698737006487 putative PBP binding regions; other site 698737006488 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698737006489 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698737006490 dimer interface [polypeptide binding]; other site 698737006491 putative radical transfer pathway; other site 698737006492 diiron center [ion binding]; other site 698737006493 tyrosyl radical; other site 698737006494 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 698737006495 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698737006496 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698737006497 active site 698737006498 dimer interface [polypeptide binding]; other site 698737006499 catalytic residues [active] 698737006500 effector binding site; other site 698737006501 R2 peptide binding site; other site 698737006502 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 698737006503 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 698737006504 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 698737006505 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698737006506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006507 putative substrate translocation pore; other site 698737006508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006509 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698737006510 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 698737006511 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 698737006512 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 698737006513 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737006514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737006515 homodimer interface [polypeptide binding]; other site 698737006516 catalytic residue [active] 698737006517 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698737006518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006519 putative substrate translocation pore; other site 698737006520 POT family; Region: PTR2; cl17359 698737006521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737006522 dimer interface [polypeptide binding]; other site 698737006523 conserved gate region; other site 698737006524 ABC-ATPase subunit interface; other site 698737006525 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698737006526 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 698737006527 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 698737006528 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 698737006529 Walker A/P-loop; other site 698737006530 ATP binding site [chemical binding]; other site 698737006531 Q-loop/lid; other site 698737006532 ABC transporter signature motif; other site 698737006533 Walker B; other site 698737006534 D-loop; other site 698737006535 H-loop/switch region; other site 698737006536 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 698737006537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737006538 ATP binding site [chemical binding]; other site 698737006539 putative Mg++ binding site [ion binding]; other site 698737006540 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737006541 nucleotide binding region [chemical binding]; other site 698737006542 ATP-binding site [chemical binding]; other site 698737006543 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 698737006544 HRDC domain; Region: HRDC; pfam00570 698737006545 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698737006546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737006547 Walker A/P-loop; other site 698737006548 ATP binding site [chemical binding]; other site 698737006549 Q-loop/lid; other site 698737006550 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737006551 ABC transporter; Region: ABC_tran_2; pfam12848 698737006552 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 698737006553 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 698737006554 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 698737006555 Predicted integral membrane protein [Function unknown]; Region: COG5650 698737006556 Sulfatase; Region: Sulfatase; pfam00884 698737006557 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 698737006558 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 698737006559 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 698737006560 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 698737006561 substrate-cofactor binding pocket; other site 698737006562 homodimer interface [polypeptide binding]; other site 698737006563 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 698737006564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737006565 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 698737006566 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698737006567 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698737006568 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698737006569 glutamine binding [chemical binding]; other site 698737006570 catalytic triad [active] 698737006571 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 698737006572 Ligand Binding Site [chemical binding]; other site 698737006573 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 698737006574 active site 698737006575 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 698737006576 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 698737006577 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 698737006578 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 698737006579 Ligand binding site; other site 698737006580 Putative Catalytic site; other site 698737006581 DXD motif; other site 698737006582 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698737006583 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698737006584 active site 698737006585 catalytic tetrad [active] 698737006586 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698737006587 Domain of unknown function DUF21; Region: DUF21; pfam01595 698737006588 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698737006589 Transporter associated domain; Region: CorC_HlyC; smart01091 698737006590 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 698737006591 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698737006592 active site 698737006593 phosphorylation site [posttranslational modification] 698737006594 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 698737006595 active site 698737006596 P-loop; other site 698737006597 phosphorylation site [posttranslational modification] 698737006598 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 698737006599 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698737006600 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698737006601 putative substrate binding site [chemical binding]; other site 698737006602 putative ATP binding site [chemical binding]; other site 698737006603 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698737006604 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 698737006605 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 698737006606 putative deacylase active site [active] 698737006607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006608 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698737006609 putative substrate translocation pore; other site 698737006610 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 698737006611 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698737006612 DNA photolyase; Region: DNA_photolyase; pfam00875 698737006613 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 698737006614 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 698737006615 transmembrane helices; other site 698737006616 malate dehydrogenase; Reviewed; Region: PRK06223 698737006617 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 698737006618 NAD(P) binding site [chemical binding]; other site 698737006619 dimer interface [polypeptide binding]; other site 698737006620 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737006621 substrate binding site [chemical binding]; other site 698737006622 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698737006623 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 698737006624 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698737006625 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737006626 MarR family; Region: MarR; pfam01047 698737006627 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 698737006628 hypothetical protein; Validated; Region: PRK00124 698737006629 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 698737006630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698737006631 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 698737006632 Protein of unknown function (DUF456); Region: DUF456; pfam04306 698737006633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006634 sugar efflux transporter; Region: 2A0120; TIGR00899 698737006635 putative substrate translocation pore; other site 698737006636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737006637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698737006638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698737006639 dimerization interface [polypeptide binding]; other site 698737006640 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 698737006641 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 698737006642 hypothetical protein; Provisional; Region: PRK12378 698737006643 MarR family; Region: MarR_2; cl17246 698737006644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 698737006645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698737006646 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 698737006647 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 698737006648 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698737006649 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698737006650 Surface antigen [General function prediction only]; Region: COG3942 698737006651 CHAP domain; Region: CHAP; pfam05257 698737006652 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 698737006653 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 698737006654 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698737006655 FtsX-like permease family; Region: FtsX; pfam02687 698737006656 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737006657 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698737006658 Walker A/P-loop; other site 698737006659 ATP binding site [chemical binding]; other site 698737006660 Q-loop/lid; other site 698737006661 ABC transporter signature motif; other site 698737006662 Walker B; other site 698737006663 D-loop; other site 698737006664 H-loop/switch region; other site 698737006665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737006666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 698737006667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737006668 ATP binding site [chemical binding]; other site 698737006669 Mg2+ binding site [ion binding]; other site 698737006670 G-X-G motif; other site 698737006671 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737006672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737006673 active site 698737006674 phosphorylation site [posttranslational modification] 698737006675 intermolecular recognition site; other site 698737006676 dimerization interface [polypeptide binding]; other site 698737006677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737006678 DNA binding site [nucleotide binding] 698737006679 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698737006680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737006681 NAD(P) binding site [chemical binding]; other site 698737006682 active site 698737006683 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 698737006684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737006685 Coenzyme A binding pocket [chemical binding]; other site 698737006686 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 698737006687 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 698737006688 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 698737006689 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698737006690 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 698737006691 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 698737006692 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 698737006693 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698737006694 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698737006695 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006696 ABC-ATPase subunit interface; other site 698737006697 dimer interface [polypeptide binding]; other site 698737006698 putative PBP binding regions; other site 698737006699 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698737006700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006701 ABC-ATPase subunit interface; other site 698737006702 dimer interface [polypeptide binding]; other site 698737006703 putative PBP binding regions; other site 698737006704 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698737006705 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698737006706 Walker A/P-loop; other site 698737006707 ATP binding site [chemical binding]; other site 698737006708 Q-loop/lid; other site 698737006709 ABC transporter signature motif; other site 698737006710 Walker B; other site 698737006711 D-loop; other site 698737006712 H-loop/switch region; other site 698737006713 Uncharacterized conserved protein [Function unknown]; Region: COG1284 698737006714 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 698737006715 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 698737006716 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698737006717 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698737006718 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698737006719 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698737006720 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737006721 active site 698737006722 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698737006723 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737006724 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 698737006725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 698737006726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698737006727 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737006728 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698737006729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737006730 Walker A/P-loop; other site 698737006731 ATP binding site [chemical binding]; other site 698737006732 Q-loop/lid; other site 698737006733 ABC transporter signature motif; other site 698737006734 Walker B; other site 698737006735 D-loop; other site 698737006736 H-loop/switch region; other site 698737006737 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698737006738 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 698737006739 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 698737006740 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698737006741 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 698737006742 active site 698737006743 nucleotide binding site [chemical binding]; other site 698737006744 HIGH motif; other site 698737006745 KMSKS motif; other site 698737006746 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698737006747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737006748 active site 698737006749 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698737006750 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 698737006751 ABC-2 type transporter; Region: ABC2_membrane; cl17235 698737006752 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 698737006753 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 698737006754 Walker A/P-loop; other site 698737006755 ATP binding site [chemical binding]; other site 698737006756 Q-loop/lid; other site 698737006757 ABC transporter signature motif; other site 698737006758 Walker B; other site 698737006759 D-loop; other site 698737006760 H-loop/switch region; other site 698737006761 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 698737006762 formate dehydrogenase; Provisional; Region: PRK07574 698737006763 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 698737006764 NAD binding site [chemical binding]; other site 698737006765 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 698737006766 putative myristoylated protein; Provisional; Region: PHA03056 698737006767 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 698737006768 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 698737006769 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 698737006770 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 698737006771 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698737006772 FeoA domain; Region: FeoA; pfam04023 698737006773 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 698737006774 ABC transporter; Region: ABC_tran; pfam00005 698737006775 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 698737006776 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006777 ABC-ATPase subunit interface; other site 698737006778 dimer interface [polypeptide binding]; other site 698737006779 putative PBP binding regions; other site 698737006780 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 698737006781 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 698737006782 metal binding site [ion binding]; metal-binding site 698737006783 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698737006784 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 698737006785 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 698737006786 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 698737006787 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 698737006788 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698737006789 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 698737006790 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 698737006791 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 698737006792 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 698737006793 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698737006794 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 698737006795 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698737006796 active site 698737006797 DNA binding site [nucleotide binding] 698737006798 Int/Topo IB signature motif; other site 698737006799 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 698737006800 Protein of unknown function, DUF606; Region: DUF606; pfam04657 698737006801 Protein of unknown function, DUF606; Region: DUF606; pfam04657 698737006802 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698737006803 HlyD family secretion protein; Region: HlyD_3; pfam13437 698737006804 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 698737006805 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698737006806 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698737006807 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698737006808 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 698737006809 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 698737006810 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698737006811 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 698737006812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737006813 motif II; other site 698737006814 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 698737006815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698737006816 ABC-ATPase subunit interface; other site 698737006817 dimer interface [polypeptide binding]; other site 698737006818 putative PBP binding regions; other site 698737006819 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 698737006820 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698737006821 putative binding site residues; other site 698737006822 Protein of unknown function (DUF805); Region: DUF805; pfam05656 698737006823 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698737006824 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698737006825 DNA binding residues [nucleotide binding] 698737006826 dimer interface [polypeptide binding]; other site 698737006827 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698737006828 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698737006829 minor groove reading motif; other site 698737006830 helix-hairpin-helix signature motif; other site 698737006831 active site 698737006832 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698737006833 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 698737006834 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698737006835 active site 698737006836 HIGH motif; other site 698737006837 KMSK motif region; other site 698737006838 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698737006839 tRNA binding surface [nucleotide binding]; other site 698737006840 anticodon binding site; other site 698737006841 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 698737006842 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 698737006843 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698737006844 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 698737006845 NAD binding site [chemical binding]; other site 698737006846 substrate binding site [chemical binding]; other site 698737006847 catalytic Zn binding site [ion binding]; other site 698737006848 tetramer interface [polypeptide binding]; other site 698737006849 structural Zn binding site [ion binding]; other site 698737006850 YwhD family; Region: YwhD; pfam08741 698737006851 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 698737006852 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698737006853 Zn2+ binding site [ion binding]; other site 698737006854 Mg2+ binding site [ion binding]; other site 698737006855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 698737006856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737006857 Coenzyme A binding pocket [chemical binding]; other site 698737006858 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 698737006859 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698737006860 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698737006861 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698737006862 active site 698737006863 catalytic tetrad [active] 698737006864 Predicted transcriptional regulator [Transcription]; Region: COG1959 698737006865 Transcriptional regulator; Region: Rrf2; pfam02082 698737006866 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698737006867 CHAP domain; Region: CHAP; pfam05257 698737006868 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698737006869 amidase catalytic site [active] 698737006870 Zn binding residues [ion binding]; other site 698737006871 substrate binding site [chemical binding]; other site 698737006872 Bacterial SH3 domain; Region: SH3_5; pfam08460 698737006873 Bacteriophage holin; Region: Phage_holin_1; pfam04531 698737006874 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 698737006875 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 698737006876 active site 698737006877 oxyanion hole [active] 698737006878 catalytic triad [active] 698737006879 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 698737006880 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 698737006881 Phage tail protein; Region: Sipho_tail; pfam05709 698737006882 Phage-related protein [Function unknown]; Region: COG5412 698737006883 membrane protein P6; Region: PHA01399 698737006884 Phage protein; Region: DUF3647; pfam12363 698737006885 Phage major tail protein 2; Region: Phage_tail_2; cl11463 698737006886 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 698737006887 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 698737006888 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 698737006889 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 698737006890 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 698737006891 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 698737006892 Phage terminase large subunit; Region: Terminase_3; cl12054 698737006893 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 698737006894 Transcriptional activator RinB; Region: RinB; pfam06116 698737006895 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 698737006896 dUTPase; Region: dUTPase_2; pfam08761 698737006897 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 698737006898 active site 698737006899 homodimer interface [polypeptide binding]; other site 698737006900 metal binding site [ion binding]; metal-binding site 698737006901 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 698737006902 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 698737006903 Endodeoxyribonuclease RusA; Region: RusA; cl01885 698737006904 Protein of unknown function (DUF3269); Region: DUF3269; pfam11673 698737006905 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 698737006906 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698737006907 Walker A motif; other site 698737006908 ATP binding site [chemical binding]; other site 698737006909 Walker B motif; other site 698737006910 DNA binding loops [nucleotide binding] 698737006911 potential frameshift: common BLAST hit: gi|88195753|ref|YP_500562.1| phi PV83 orf 20-like protein 698737006912 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 698737006913 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 698737006914 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698737006915 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698737006916 dimer interface [polypeptide binding]; other site 698737006917 ssDNA binding site [nucleotide binding]; other site 698737006918 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737006919 ERF superfamily; Region: ERF; pfam04404 698737006920 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 698737006921 Phage anti-repressor protein [Transcription]; Region: COG3561 698737006922 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 698737006923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737006924 non-specific DNA binding site [nucleotide binding]; other site 698737006925 salt bridge; other site 698737006926 sequence-specific DNA binding site [nucleotide binding]; other site 698737006927 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737006928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737006929 non-specific DNA binding site [nucleotide binding]; other site 698737006930 salt bridge; other site 698737006931 sequence-specific DNA binding site [nucleotide binding]; other site 698737006932 Domain of unknown function (DUF955); Region: DUF955; pfam06114 698737006933 Abi-like protein; Region: Abi_2; pfam07751 698737006934 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 698737006935 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 698737006936 catalytic residues [active] 698737006937 catalytic nucleophile [active] 698737006938 Presynaptic Site I dimer interface [polypeptide binding]; other site 698737006939 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 698737006940 Synaptic Flat tetramer interface [polypeptide binding]; other site 698737006941 Synaptic Site I dimer interface [polypeptide binding]; other site 698737006942 DNA binding site [nucleotide binding] 698737006943 Recombinase; Region: Recombinase; pfam07508 698737006944 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 698737006945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737006946 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698737006947 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 698737006948 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 698737006949 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 698737006950 diphosphomevalonate decarboxylase; Region: PLN02407 698737006951 mevalonate kinase; Region: mevalon_kin; TIGR00549 698737006952 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698737006953 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698737006954 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 698737006955 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 698737006956 putative heme peroxidase; Provisional; Region: PRK12276 698737006957 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 698737006958 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698737006959 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 698737006960 Uncharacterized conserved protein [Function unknown]; Region: COG3610 698737006961 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 698737006962 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 698737006963 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698737006964 ligand binding site [chemical binding]; other site 698737006965 active site 698737006966 UGI interface [polypeptide binding]; other site 698737006967 catalytic site [active] 698737006968 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 698737006969 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 698737006970 active site 698737006971 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698737006972 dimer interface [polypeptide binding]; other site 698737006973 substrate binding site [chemical binding]; other site 698737006974 ATP binding site [chemical binding]; other site 698737006975 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 698737006976 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 698737006977 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 698737006978 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 698737006979 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 698737006980 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 698737006981 proline/glycine betaine transporter; Provisional; Region: PRK10642 698737006982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737006983 putative substrate translocation pore; other site 698737006984 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 698737006985 tetramer interface [polypeptide binding]; other site 698737006986 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 698737006987 active site 698737006988 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 698737006989 active site 698737006990 dimer interface [polypeptide binding]; other site 698737006991 magnesium binding site [ion binding]; other site 698737006992 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 698737006993 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 698737006994 putative GTP cyclohydrolase; Provisional; Region: PRK13674 698737006995 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698737006996 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737006997 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 698737006998 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 698737006999 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 698737007000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 698737007001 active site 698737007002 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 698737007003 Rib/alpha-like repeat; Region: Rib; cl07159 698737007004 Rib/alpha-like repeat; Region: Rib; cl07159 698737007005 Predicted flavoprotein [General function prediction only]; Region: COG0431 698737007006 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 698737007007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737007008 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698737007009 active site 698737007010 motif I; other site 698737007011 motif II; other site 698737007012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737007013 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698737007014 nucleoside/Zn binding site; other site 698737007015 dimer interface [polypeptide binding]; other site 698737007016 catalytic motif [active] 698737007017 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 698737007018 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 698737007019 Substrate-binding site [chemical binding]; other site 698737007020 Substrate specificity [chemical binding]; other site 698737007021 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 698737007022 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 698737007023 Substrate-binding site [chemical binding]; other site 698737007024 Substrate specificity [chemical binding]; other site 698737007025 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698737007026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698737007027 motif II; other site 698737007028 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 698737007029 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 698737007030 hexamer interface [polypeptide binding]; other site 698737007031 ligand binding site [chemical binding]; other site 698737007032 putative active site [active] 698737007033 NAD(P) binding site [chemical binding]; other site 698737007034 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 698737007035 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698737007036 tetramer interface [polypeptide binding]; other site 698737007037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007038 catalytic residue [active] 698737007039 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 698737007040 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698737007041 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698737007042 homodimer interface [polypeptide binding]; other site 698737007043 substrate-cofactor binding pocket; other site 698737007044 catalytic residue [active] 698737007045 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 698737007046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737007047 NAD(P) binding site [chemical binding]; other site 698737007048 active site 698737007049 potential frameshift: common BLAST hit: gi|224475581|ref|YP_002633187.1| LysE type translocator 698737007050 LysE type translocator; Region: LysE; cl00565 698737007051 LysE type translocator; Region: LysE; cl00565 698737007052 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 698737007053 nudix motif; other site 698737007054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698737007055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737007056 Coenzyme A binding pocket [chemical binding]; other site 698737007057 ornithine cyclodeaminase; Validated; Region: PRK08618 698737007058 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 698737007059 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 698737007060 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 698737007061 substrate-cofactor binding pocket; other site 698737007062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007063 catalytic residue [active] 698737007064 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698737007065 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 698737007066 metal binding site [ion binding]; metal-binding site 698737007067 dimer interface [polypeptide binding]; other site 698737007068 elongation factor Tu; Reviewed; Region: PRK00049 698737007069 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698737007070 G1 box; other site 698737007071 GEF interaction site [polypeptide binding]; other site 698737007072 GTP/Mg2+ binding site [chemical binding]; other site 698737007073 Switch I region; other site 698737007074 G2 box; other site 698737007075 G3 box; other site 698737007076 Switch II region; other site 698737007077 G4 box; other site 698737007078 G5 box; other site 698737007079 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698737007080 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698737007081 Antibiotic Binding Site [chemical binding]; other site 698737007082 elongation factor G; Reviewed; Region: PRK00007 698737007083 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698737007084 G1 box; other site 698737007085 putative GEF interaction site [polypeptide binding]; other site 698737007086 GTP/Mg2+ binding site [chemical binding]; other site 698737007087 Switch I region; other site 698737007088 G2 box; other site 698737007089 G3 box; other site 698737007090 Switch II region; other site 698737007091 G4 box; other site 698737007092 G5 box; other site 698737007093 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698737007094 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698737007095 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698737007096 30S ribosomal protein S7; Validated; Region: PRK05302 698737007097 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698737007098 S17 interaction site [polypeptide binding]; other site 698737007099 S8 interaction site; other site 698737007100 16S rRNA interaction site [nucleotide binding]; other site 698737007101 streptomycin interaction site [chemical binding]; other site 698737007102 23S rRNA interaction site [nucleotide binding]; other site 698737007103 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698737007104 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 698737007105 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 698737007106 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698737007107 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 698737007108 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698737007109 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698737007110 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698737007111 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698737007112 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698737007113 G-loop; other site 698737007114 DNA binding site [nucleotide binding] 698737007115 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698737007116 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 698737007117 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698737007118 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698737007119 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698737007120 RPB12 interaction site [polypeptide binding]; other site 698737007121 RPB10 interaction site [polypeptide binding]; other site 698737007122 RPB1 interaction site [polypeptide binding]; other site 698737007123 RPB11 interaction site [polypeptide binding]; other site 698737007124 RPB3 interaction site [polypeptide binding]; other site 698737007125 RPB12 interaction site [polypeptide binding]; other site 698737007126 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698737007127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737007128 S-adenosylmethionine binding site [chemical binding]; other site 698737007129 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 698737007130 peripheral dimer interface [polypeptide binding]; other site 698737007131 core dimer interface [polypeptide binding]; other site 698737007132 L10 interface [polypeptide binding]; other site 698737007133 L11 interface [polypeptide binding]; other site 698737007134 putative EF-Tu interaction site [polypeptide binding]; other site 698737007135 putative EF-G interaction site [polypeptide binding]; other site 698737007136 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698737007137 23S rRNA interface [nucleotide binding]; other site 698737007138 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698737007139 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698737007140 mRNA/rRNA interface [nucleotide binding]; other site 698737007141 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698737007142 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698737007143 23S rRNA interface [nucleotide binding]; other site 698737007144 L7/L12 interface [polypeptide binding]; other site 698737007145 putative thiostrepton binding site; other site 698737007146 L25 interface [polypeptide binding]; other site 698737007147 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698737007148 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698737007149 putative homodimer interface [polypeptide binding]; other site 698737007150 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 698737007151 heterodimer interface [polypeptide binding]; other site 698737007152 homodimer interface [polypeptide binding]; other site 698737007153 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 698737007154 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698737007155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698737007156 YacP-like NYN domain; Region: NYN_YacP; cl01491 698737007157 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698737007158 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 698737007159 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 698737007160 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 698737007161 active site 698737007162 metal binding site [ion binding]; metal-binding site 698737007163 dimerization interface [polypeptide binding]; other site 698737007164 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698737007165 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698737007166 active site 698737007167 HIGH motif; other site 698737007168 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698737007169 KMSKS motif; other site 698737007170 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698737007171 tRNA binding surface [nucleotide binding]; other site 698737007172 anticodon binding site; other site 698737007173 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 698737007174 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698737007175 trimer interface [polypeptide binding]; other site 698737007176 active site 698737007177 substrate binding site [chemical binding]; other site 698737007178 CoA binding site [chemical binding]; other site 698737007179 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698737007180 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698737007181 active site 698737007182 HIGH motif; other site 698737007183 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698737007184 active site 698737007185 KMSKS motif; other site 698737007186 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 698737007187 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 698737007188 putative active site [active] 698737007189 DNA repair protein RadA; Provisional; Region: PRK11823 698737007190 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 698737007191 Walker A motif/ATP binding site; other site 698737007192 ATP binding site [chemical binding]; other site 698737007193 Walker B motif; other site 698737007194 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 698737007195 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 698737007196 Clp amino terminal domain; Region: Clp_N; pfam02861 698737007197 Clp amino terminal domain; Region: Clp_N; pfam02861 698737007198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737007199 Walker A motif; other site 698737007200 ATP binding site [chemical binding]; other site 698737007201 Walker B motif; other site 698737007202 arginine finger; other site 698737007203 UvrB/uvrC motif; Region: UVR; pfam02151 698737007204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737007205 Walker A motif; other site 698737007206 ATP binding site [chemical binding]; other site 698737007207 Walker B motif; other site 698737007208 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 698737007209 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 698737007210 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 698737007211 ADP binding site [chemical binding]; other site 698737007212 phosphagen binding site; other site 698737007213 substrate specificity loop; other site 698737007214 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 698737007215 UvrB/uvrC motif; Region: UVR; pfam02151 698737007216 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 698737007217 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 698737007218 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 698737007219 Nucleoside recognition; Region: Gate; pfam07670 698737007220 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 698737007221 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698737007222 predicted active site [active] 698737007223 catalytic triad [active] 698737007224 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 698737007225 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698737007226 active site 698737007227 multimer interface [polypeptide binding]; other site 698737007228 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698737007229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737007230 DNA-binding site [nucleotide binding]; DNA binding site 698737007231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698737007232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007233 homodimer interface [polypeptide binding]; other site 698737007234 catalytic residue [active] 698737007235 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698737007236 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698737007237 dimer interface [polypeptide binding]; other site 698737007238 putative anticodon binding site; other site 698737007239 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 698737007240 motif 1; other site 698737007241 active site 698737007242 motif 2; other site 698737007243 motif 3; other site 698737007244 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698737007245 catalytic center binding site [active] 698737007246 ATP binding site [chemical binding]; other site 698737007247 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698737007248 homooctamer interface [polypeptide binding]; other site 698737007249 active site 698737007250 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698737007251 dihydropteroate synthase; Region: DHPS; TIGR01496 698737007252 substrate binding pocket [chemical binding]; other site 698737007253 dimer interface [polypeptide binding]; other site 698737007254 inhibitor binding site; inhibition site 698737007255 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698737007256 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698737007257 dimer interface [polypeptide binding]; other site 698737007258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007259 catalytic residue [active] 698737007260 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 698737007261 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 698737007262 dimerization interface [polypeptide binding]; other site 698737007263 domain crossover interface; other site 698737007264 redox-dependent activation switch; other site 698737007265 FtsH Extracellular; Region: FtsH_ext; pfam06480 698737007266 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698737007267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737007268 Walker A motif; other site 698737007269 ATP binding site [chemical binding]; other site 698737007270 Walker B motif; other site 698737007271 arginine finger; other site 698737007272 Peptidase family M41; Region: Peptidase_M41; pfam01434 698737007273 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737007274 active site 698737007275 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 698737007276 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698737007277 Ligand Binding Site [chemical binding]; other site 698737007278 TilS substrate C-terminal domain; Region: TilS_C; smart00977 698737007279 hypothetical protein; Provisional; Region: PRK08582 698737007280 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 698737007281 RNA binding site [nucleotide binding]; other site 698737007282 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 698737007283 Septum formation initiator; Region: DivIC; pfam04977 698737007284 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698737007285 RNA binding surface [nucleotide binding]; other site 698737007286 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 698737007287 putative SAM binding site [chemical binding]; other site 698737007288 putative homodimer interface [polypeptide binding]; other site 698737007289 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 698737007290 homodimer interface [polypeptide binding]; other site 698737007291 metal binding site [ion binding]; metal-binding site 698737007292 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 698737007293 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 698737007294 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698737007295 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 698737007296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698737007297 ATP binding site [chemical binding]; other site 698737007298 putative Mg++ binding site [ion binding]; other site 698737007299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698737007300 nucleotide binding region [chemical binding]; other site 698737007301 ATP-binding site [chemical binding]; other site 698737007302 TRCF domain; Region: TRCF; pfam03461 698737007303 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698737007304 putative active site [active] 698737007305 catalytic residue [active] 698737007306 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698737007307 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698737007308 5S rRNA interface [nucleotide binding]; other site 698737007309 CTC domain interface [polypeptide binding]; other site 698737007310 L16 interface [polypeptide binding]; other site 698737007311 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 698737007312 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698737007313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737007314 active site 698737007315 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 698737007316 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698737007317 Substrate binding site; other site 698737007318 Mg++ binding site; other site 698737007319 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698737007320 active site 698737007321 substrate binding site [chemical binding]; other site 698737007322 CoA binding site [chemical binding]; other site 698737007323 regulatory protein SpoVG; Reviewed; Region: PRK13259 698737007324 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 698737007325 homotrimer interaction site [polypeptide binding]; other site 698737007326 putative active site [active] 698737007327 pur operon repressor; Provisional; Region: PRK09213 698737007328 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 698737007329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737007330 active site 698737007331 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 698737007332 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698737007333 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698737007334 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 698737007335 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 698737007336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737007337 S-adenosylmethionine binding site [chemical binding]; other site 698737007338 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 698737007339 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 698737007340 putative active site [active] 698737007341 putative metal binding site [ion binding]; other site 698737007342 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 698737007343 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 698737007344 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698737007345 active site 698737007346 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 698737007347 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698737007348 active site 698737007349 HIGH motif; other site 698737007350 KMSKS motif; other site 698737007351 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698737007352 tRNA binding surface [nucleotide binding]; other site 698737007353 anticodon binding site; other site 698737007354 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 698737007355 dimer interface [polypeptide binding]; other site 698737007356 putative tRNA-binding site [nucleotide binding]; other site 698737007357 Predicted methyltransferases [General function prediction only]; Region: COG0313 698737007358 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 698737007359 putative SAM binding site [chemical binding]; other site 698737007360 putative homodimer interface [polypeptide binding]; other site 698737007361 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 698737007362 GIY-YIG motif/motif A; other site 698737007363 putative active site [active] 698737007364 putative metal binding site [ion binding]; other site 698737007365 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 698737007366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737007367 S-adenosylmethionine binding site [chemical binding]; other site 698737007368 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 698737007369 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 698737007370 DNA polymerase III subunit delta'; Validated; Region: PRK08058 698737007371 DNA polymerase III subunit delta'; Validated; Region: PRK08485 698737007372 Protein of unknown function (DUF970); Region: DUF970; pfam06153 698737007373 thymidylate kinase; Validated; Region: tmk; PRK00698 698737007374 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698737007375 TMP-binding site; other site 698737007376 ATP-binding site [chemical binding]; other site 698737007377 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 698737007378 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737007379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737007380 catalytic residue [active] 698737007381 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 698737007382 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698737007383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737007384 Coenzyme A binding pocket [chemical binding]; other site 698737007385 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 698737007386 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 698737007387 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007388 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007389 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007390 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007391 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007392 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007393 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007394 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007395 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007396 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007397 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 698737007398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 698737007399 Transposase; Region: DDE_Tnp_ISL3; pfam01610 698737007400 recombination protein RecR; Reviewed; Region: recR; PRK00076 698737007401 RecR protein; Region: RecR; pfam02132 698737007402 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698737007403 putative active site [active] 698737007404 putative metal-binding site [ion binding]; other site 698737007405 tetramer interface [polypeptide binding]; other site 698737007406 hypothetical protein; Validated; Region: PRK00153 698737007407 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 698737007408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737007409 Walker A motif; other site 698737007410 ATP binding site [chemical binding]; other site 698737007411 Walker B motif; other site 698737007412 arginine finger; other site 698737007413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698737007414 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698737007415 Coenzyme A binding pocket [chemical binding]; other site 698737007416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698737007417 DNA-binding site [nucleotide binding]; DNA binding site 698737007418 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 698737007419 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 698737007420 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 698737007421 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 698737007422 Ca binding site [ion binding]; other site 698737007423 active site 698737007424 catalytic site [active] 698737007425 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 698737007426 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 698737007427 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698737007428 active site turn [active] 698737007429 phosphorylation site [posttranslational modification] 698737007430 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 698737007431 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 698737007432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 698737007433 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 698737007434 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 698737007435 active site 698737007436 dimer interface [polypeptide binding]; other site 698737007437 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 698737007438 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 698737007439 active site 698737007440 FMN binding site [chemical binding]; other site 698737007441 substrate binding site [chemical binding]; other site 698737007442 3Fe-4S cluster binding site [ion binding]; other site 698737007443 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 698737007444 domain interface; other site 698737007445 Transcriptional regulator [Transcription]; Region: LysR; COG0583 698737007446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 698737007447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698737007448 dimerization interface [polypeptide binding]; other site 698737007449 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 698737007450 YibE/F-like protein; Region: YibE_F; cl02259 698737007451 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 698737007452 nudix motif; other site 698737007453 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698737007454 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 698737007455 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698737007456 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 698737007457 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 698737007458 CHAP domain; Region: CHAP; pfam05257 698737007459 Surface antigen [General function prediction only]; Region: COG3942 698737007460 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 698737007461 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 698737007462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698737007463 dimer interface [polypeptide binding]; other site 698737007464 conserved gate region; other site 698737007465 ABC-ATPase subunit interface; other site 698737007466 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 698737007467 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 698737007468 Walker A/P-loop; other site 698737007469 ATP binding site [chemical binding]; other site 698737007470 Q-loop/lid; other site 698737007471 ABC transporter signature motif; other site 698737007472 Walker B; other site 698737007473 D-loop; other site 698737007474 H-loop/switch region; other site 698737007475 NIL domain; Region: NIL; pfam09383 698737007476 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698737007477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737007478 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698737007479 Walker A/P-loop; other site 698737007480 ATP binding site [chemical binding]; other site 698737007481 Q-loop/lid; other site 698737007482 ABC transporter signature motif; other site 698737007483 Walker B; other site 698737007484 D-loop; other site 698737007485 H-loop/switch region; other site 698737007486 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698737007487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 698737007488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737007489 Walker A/P-loop; other site 698737007490 ATP binding site [chemical binding]; other site 698737007491 Q-loop/lid; other site 698737007492 ABC transporter signature motif; other site 698737007493 Walker B; other site 698737007494 D-loop; other site 698737007495 H-loop/switch region; other site 698737007496 cystathionine beta-lyase; Provisional; Region: PRK07671 698737007497 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698737007498 homodimer interface [polypeptide binding]; other site 698737007499 substrate-cofactor binding pocket; other site 698737007500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007501 catalytic residue [active] 698737007502 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698737007503 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698737007504 dimer interface [polypeptide binding]; other site 698737007505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007506 catalytic residue [active] 698737007507 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 698737007508 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 698737007509 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 698737007510 Na2 binding site [ion binding]; other site 698737007511 putative substrate binding site 1 [chemical binding]; other site 698737007512 Na binding site 1 [ion binding]; other site 698737007513 putative substrate binding site 2 [chemical binding]; other site 698737007514 Esterase/lipase [General function prediction only]; Region: COG1647 698737007515 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 698737007516 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698737007517 active site 698737007518 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 698737007519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 698737007520 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 698737007521 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 698737007522 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 698737007523 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698737007524 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698737007525 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 698737007526 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 698737007527 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698737007528 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698737007529 putative DNA binding site [nucleotide binding]; other site 698737007530 putative Zn2+ binding site [ion binding]; other site 698737007531 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 698737007532 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 698737007533 active site 698737007534 nucleophile elbow; other site 698737007535 GMP synthase; Reviewed; Region: guaA; PRK00074 698737007536 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698737007537 AMP/PPi binding site [chemical binding]; other site 698737007538 candidate oxyanion hole; other site 698737007539 catalytic triad [active] 698737007540 potential glutamine specificity residues [chemical binding]; other site 698737007541 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698737007542 ATP Binding subdomain [chemical binding]; other site 698737007543 Ligand Binding sites [chemical binding]; other site 698737007544 Dimerization subdomain; other site 698737007545 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698737007546 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 698737007547 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 698737007548 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 698737007549 active site 698737007550 xanthine permease; Region: pbuX; TIGR03173 698737007551 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698737007552 active site 698737007553 Heat induced stress protein YflT; Region: YflT; pfam11181 698737007554 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 698737007555 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698737007556 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698737007557 dimer interface [polypeptide binding]; other site 698737007558 FMN binding site [chemical binding]; other site 698737007559 NADPH bind site [chemical binding]; other site 698737007560 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 698737007561 peroxiredoxin; Region: AhpC; TIGR03137 698737007562 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698737007563 dimer interface [polypeptide binding]; other site 698737007564 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698737007565 catalytic triad [active] 698737007566 peroxidatic and resolving cysteines [active] 698737007567 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 698737007568 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 698737007569 catalytic residue [active] 698737007570 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 698737007571 catalytic residues [active] 698737007572 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 698737007573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698737007574 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698737007575 catalytic core [active] 698737007576 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 698737007577 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 698737007578 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 698737007579 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698737007580 dimer interface [polypeptide binding]; other site 698737007581 ssDNA binding site [nucleotide binding]; other site 698737007582 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698737007583 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 698737007584 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 698737007585 active site 698737007586 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698737007587 GTP-binding protein YchF; Reviewed; Region: PRK09601 698737007588 YchF GTPase; Region: YchF; cd01900 698737007589 G1 box; other site 698737007590 GTP/Mg2+ binding site [chemical binding]; other site 698737007591 Switch I region; other site 698737007592 G2 box; other site 698737007593 Switch II region; other site 698737007594 G3 box; other site 698737007595 G4 box; other site 698737007596 G5 box; other site 698737007597 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698737007598 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 698737007599 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 698737007600 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698737007601 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 698737007602 ParB-like nuclease domain; Region: ParB; smart00470 698737007603 cystathionine gamma-synthase; Reviewed; Region: PRK08247 698737007604 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698737007605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698737007606 catalytic residue [active] 698737007607 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 698737007608 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698737007609 homodimer interface [polypeptide binding]; other site 698737007610 substrate-cofactor binding pocket; other site 698737007611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698737007612 catalytic residue [active] 698737007613 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 698737007614 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 698737007615 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698737007616 FAD binding site [chemical binding]; other site 698737007617 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 698737007618 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 698737007619 THF binding site; other site 698737007620 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 698737007621 substrate binding site [chemical binding]; other site 698737007622 THF binding site; other site 698737007623 zinc-binding site [ion binding]; other site 698737007624 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 698737007625 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 698737007626 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 698737007627 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 698737007628 Nucleoside recognition; Region: Gate; pfam07670 698737007629 Nucleoside recognition; Region: Gate; pfam07670 698737007630 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698737007631 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 698737007632 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 698737007633 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698737007634 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698737007635 FtsX-like permease family; Region: FtsX; pfam02687 698737007636 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737007637 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698737007638 Walker A/P-loop; other site 698737007639 ATP binding site [chemical binding]; other site 698737007640 Q-loop/lid; other site 698737007641 ABC transporter signature motif; other site 698737007642 Walker B; other site 698737007643 D-loop; other site 698737007644 H-loop/switch region; other site 698737007645 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698737007646 HlyD family secretion protein; Region: HlyD_3; pfam13437 698737007647 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 698737007648 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698737007649 active site 698737007650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 698737007651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737007652 dimer interface [polypeptide binding]; other site 698737007653 phosphorylation site [posttranslational modification] 698737007654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737007655 ATP binding site [chemical binding]; other site 698737007656 Mg2+ binding site [ion binding]; other site 698737007657 G-X-G motif; other site 698737007658 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698737007659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737007660 Walker A/P-loop; other site 698737007661 ATP binding site [chemical binding]; other site 698737007662 Q-loop/lid; other site 698737007663 ABC transporter signature motif; other site 698737007664 Walker B; other site 698737007665 D-loop; other site 698737007666 H-loop/switch region; other site 698737007667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737007668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737007669 active site 698737007670 phosphorylation site [posttranslational modification] 698737007671 intermolecular recognition site; other site 698737007672 dimerization interface [polypeptide binding]; other site 698737007673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737007674 DNA binding site [nucleotide binding] 698737007675 galactoside permease; Reviewed; Region: lacY; PRK09528 698737007676 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 698737007677 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 698737007678 substrate binding [chemical binding]; other site 698737007679 active site 698737007680 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698737007681 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698737007682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698737007683 DNA binding site [nucleotide binding] 698737007684 domain linker motif; other site 698737007685 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 698737007686 dimerization interface [polypeptide binding]; other site 698737007687 ligand binding site [chemical binding]; other site 698737007688 sodium binding site [ion binding]; other site 698737007689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 698737007690 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698737007691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 698737007692 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 698737007693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737007694 putative substrate translocation pore; other site 698737007695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737007696 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698737007697 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 698737007698 Catalytic site [active] 698737007699 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698737007700 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 698737007701 Walker A/P-loop; other site 698737007702 ATP binding site [chemical binding]; other site 698737007703 Q-loop/lid; other site 698737007704 ABC transporter signature motif; other site 698737007705 Walker B; other site 698737007706 D-loop; other site 698737007707 H-loop/switch region; other site 698737007708 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698737007709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698737007710 non-specific DNA binding site [nucleotide binding]; other site 698737007711 salt bridge; other site 698737007712 sequence-specific DNA binding site [nucleotide binding]; other site 698737007713 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 698737007714 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 698737007715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698737007716 NAD(P) binding site [chemical binding]; other site 698737007717 active site 698737007718 polyol permease family; Region: 2A0118; TIGR00897 698737007719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698737007720 putative substrate translocation pore; other site 698737007721 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 698737007722 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 698737007723 putative N- and C-terminal domain interface [polypeptide binding]; other site 698737007724 putative active site [active] 698737007725 MgATP binding site [chemical binding]; other site 698737007726 catalytic site [active] 698737007727 metal binding site [ion binding]; metal-binding site 698737007728 putative carbohydrate binding site [chemical binding]; other site 698737007729 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698737007730 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 698737007731 inhibitor binding site; inhibition site 698737007732 catalytic Zn binding site [ion binding]; other site 698737007733 structural Zn binding site [ion binding]; other site 698737007734 NADP binding site [chemical binding]; other site 698737007735 tetramer interface [polypeptide binding]; other site 698737007736 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698737007737 DNA-binding interface [nucleotide binding]; DNA binding site 698737007738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698737007739 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 698737007740 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 698737007741 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 698737007742 ParB-like nuclease domain; Region: ParBc; pfam02195 698737007743 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 698737007744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698737007745 S-adenosylmethionine binding site [chemical binding]; other site 698737007746 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 698737007747 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 698737007748 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 698737007749 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 698737007750 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 698737007751 trmE is a tRNA modification GTPase; Region: trmE; cd04164 698737007752 G1 box; other site 698737007753 GTP/Mg2+ binding site [chemical binding]; other site 698737007754 Switch I region; other site 698737007755 G2 box; other site 698737007756 Switch II region; other site 698737007757 G3 box; other site 698737007758 G4 box; other site 698737007759 G5 box; other site 698737007760 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 698737007761 ribonuclease P; Reviewed; Region: rnpA; PRK00499 698737007762 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 698737007763 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 698737007764 DnaA N-terminal domain; Region: DnaA_N; pfam11638 698737007765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698737007766 Walker A motif; other site 698737007767 ATP binding site [chemical binding]; other site 698737007768 Walker B motif; other site 698737007769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 698737007770 arginine finger; other site 698737007771 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698737007772 DnaA box-binding interface [nucleotide binding]; other site 698737007773 DNA polymerase III subunit beta; Validated; Region: PRK05643 698737007774 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698737007775 putative DNA binding surface [nucleotide binding]; other site 698737007776 dimer interface [polypeptide binding]; other site 698737007777 beta-clamp/clamp loader binding surface; other site 698737007778 beta-clamp/translesion DNA polymerase binding surface; other site 698737007779 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 698737007780 recombination protein F; Reviewed; Region: recF; PRK00064 698737007781 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 698737007782 Walker A/P-loop; other site 698737007783 ATP binding site [chemical binding]; other site 698737007784 Q-loop/lid; other site 698737007785 ABC transporter signature motif; other site 698737007786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 698737007787 ABC transporter signature motif; other site 698737007788 Walker B; other site 698737007789 D-loop; other site 698737007790 H-loop/switch region; other site 698737007791 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698737007792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737007793 Mg2+ binding site [ion binding]; other site 698737007794 G-X-G motif; other site 698737007795 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698737007796 anchoring element; other site 698737007797 dimer interface [polypeptide binding]; other site 698737007798 ATP binding site [chemical binding]; other site 698737007799 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698737007800 active site 698737007801 putative metal-binding site [ion binding]; other site 698737007802 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698737007803 DNA gyrase subunit A; Validated; Region: PRK05560 698737007804 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 698737007805 CAP-like domain; other site 698737007806 active site 698737007807 primary dimer interface [polypeptide binding]; other site 698737007808 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007809 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007810 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007811 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007812 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007813 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698737007814 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698737007815 putative substrate binding site [chemical binding]; other site 698737007816 putative ATP binding site [chemical binding]; other site 698737007817 seryl-tRNA synthetase; Provisional; Region: PRK05431 698737007818 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698737007819 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 698737007820 dimer interface [polypeptide binding]; other site 698737007821 active site 698737007822 motif 1; other site 698737007823 motif 2; other site 698737007824 motif 3; other site 698737007825 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 698737007826 Predicted membrane protein [Function unknown]; Region: COG4392 698737007827 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 698737007828 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 698737007829 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 698737007830 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 698737007831 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 698737007832 DHH family; Region: DHH; pfam01368 698737007833 DHHA1 domain; Region: DHHA1; pfam02272 698737007834 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698737007835 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698737007836 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698737007837 replicative DNA helicase; Region: DnaB; TIGR00665 698737007838 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698737007839 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698737007840 Walker A motif; other site 698737007841 ATP binding site [chemical binding]; other site 698737007842 Walker B motif; other site 698737007843 DNA binding loops [nucleotide binding] 698737007844 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698737007845 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698737007846 GDP-binding site [chemical binding]; other site 698737007847 ACT binding site; other site 698737007848 IMP binding site; other site 698737007849 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698737007850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698737007851 active site 698737007852 phosphorylation site [posttranslational modification] 698737007853 intermolecular recognition site; other site 698737007854 dimerization interface [polypeptide binding]; other site 698737007855 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698737007856 DNA binding site [nucleotide binding] 698737007857 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 698737007858 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698737007859 dimerization interface [polypeptide binding]; other site 698737007860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698737007861 putative active site [active] 698737007862 heme pocket [chemical binding]; other site 698737007863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698737007864 dimer interface [polypeptide binding]; other site 698737007865 phosphorylation site [posttranslational modification] 698737007866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698737007867 ATP binding site [chemical binding]; other site 698737007868 Mg2+ binding site [ion binding]; other site 698737007869 G-X-G motif; other site 698737007870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 698737007871 YycH protein; Region: YycH; pfam07435 698737007872 YycH protein; Region: YycI; cl02015 698737007873 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 698737007874 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698737007875 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 698737007876 putative active site [active] 698737007877 putative metal binding site [ion binding]; other site 698737007878 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 698737007879 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 698737007880 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 698737007881 DXD motif; other site 698737007882 potential frameshift: common BLAST hit: gi|165976517|ref|YP_001652110.1| N-acetyl-beta-hexosaminidase 698737007883 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 698737007884 active site 698737007885 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 698737007886 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235