-- dump date 20140620_075846 -- class Genbank::misc_feature -- table misc_feature_note -- id note 176279000001 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 176279000002 ribonuclease P; Reviewed; Region: rnpA; PRK00499 176279000003 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 176279000004 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 176279000005 trmE is a tRNA modification GTPase; Region: trmE; cd04164 176279000006 G1 box; other site 176279000007 GTP/Mg2+ binding site [chemical binding]; other site 176279000008 Switch I region; other site 176279000009 G2 box; other site 176279000010 Switch II region; other site 176279000011 G3 box; other site 176279000012 G4 box; other site 176279000013 G5 box; other site 176279000014 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 176279000015 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 176279000016 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 176279000017 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 176279000018 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 176279000019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279000020 S-adenosylmethionine binding site [chemical binding]; other site 176279000021 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 176279000022 ParB-like nuclease domain; Region: ParBc; pfam02195 176279000023 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 176279000024 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 176279000025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 176279000026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176279000027 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 176279000028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176279000029 non-specific DNA binding site [nucleotide binding]; other site 176279000030 salt bridge; other site 176279000031 sequence-specific DNA binding site [nucleotide binding]; other site 176279000032 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 176279000033 HlyD family secretion protein; Region: HlyD_3; pfam13437 176279000034 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176279000035 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176279000036 Walker A/P-loop; other site 176279000037 ATP binding site [chemical binding]; other site 176279000038 Q-loop/lid; other site 176279000039 ABC transporter signature motif; other site 176279000040 Walker B; other site 176279000041 D-loop; other site 176279000042 H-loop/switch region; other site 176279000043 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 176279000044 FtsX-like permease family; Region: FtsX; pfam02687 176279000045 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 176279000046 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 176279000047 FtsX-like permease family; Region: FtsX; pfam02687 176279000048 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176279000049 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176279000050 Walker A/P-loop; other site 176279000051 ATP binding site [chemical binding]; other site 176279000052 Q-loop/lid; other site 176279000053 ABC transporter signature motif; other site 176279000054 Walker B; other site 176279000055 D-loop; other site 176279000056 H-loop/switch region; other site 176279000057 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 176279000058 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 176279000059 Catalytic site [active] 176279000060 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 176279000061 benzoate transport; Region: 2A0115; TIGR00895 176279000062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279000063 putative substrate translocation pore; other site 176279000064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279000065 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176279000066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279000067 Walker A/P-loop; other site 176279000068 ATP binding site [chemical binding]; other site 176279000069 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 176279000070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176279000071 non-specific DNA binding site [nucleotide binding]; other site 176279000072 salt bridge; other site 176279000073 sequence-specific DNA binding site [nucleotide binding]; other site 176279000074 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 176279000075 putative acyltransferase; Provisional; Region: PRK05790 176279000076 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 176279000077 dimer interface [polypeptide binding]; other site 176279000078 active site 176279000079 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 176279000080 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 176279000081 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 176279000082 THF binding site; other site 176279000083 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 176279000084 substrate binding site [chemical binding]; other site 176279000085 THF binding site; other site 176279000086 zinc-binding site [ion binding]; other site 176279000087 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 176279000088 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 176279000089 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 176279000090 FAD binding site [chemical binding]; other site 176279000091 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 176279000092 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 176279000093 homodimer interface [polypeptide binding]; other site 176279000094 substrate-cofactor binding pocket; other site 176279000095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279000096 catalytic residue [active] 176279000097 cystathionine gamma-synthase; Reviewed; Region: PRK08247 176279000098 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 176279000099 homodimer interface [polypeptide binding]; other site 176279000100 substrate-cofactor binding pocket; other site 176279000101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279000102 catalytic residue [active] 176279000103 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 176279000104 ParB-like nuclease domain; Region: ParB; smart00470 176279000105 KorB domain; Region: KorB; pfam08535 176279000106 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 176279000107 Mechanosensitive ion channel; Region: MS_channel; pfam00924 176279000108 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 176279000109 GTP-binding protein YchF; Reviewed; Region: PRK09601 176279000110 YchF GTPase; Region: YchF; cd01900 176279000111 G1 box; other site 176279000112 GTP/Mg2+ binding site [chemical binding]; other site 176279000113 Switch I region; other site 176279000114 G2 box; other site 176279000115 Switch II region; other site 176279000116 G3 box; other site 176279000117 G4 box; other site 176279000118 G5 box; other site 176279000119 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 176279000120 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 176279000121 active site 176279000122 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 176279000123 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 176279000124 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 176279000125 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 176279000126 dimer interface [polypeptide binding]; other site 176279000127 ssDNA binding site [nucleotide binding]; other site 176279000128 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176279000129 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 176279000130 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 176279000131 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 176279000132 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 176279000133 catalytic core [active] 176279000134 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 176279000135 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 176279000136 catalytic residue [active] 176279000137 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 176279000138 catalytic residues [active] 176279000139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176279000140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279000141 peroxiredoxin; Region: AhpC; TIGR03137 176279000142 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 176279000143 dimer interface [polypeptide binding]; other site 176279000144 decamer (pentamer of dimers) interface [polypeptide binding]; other site 176279000145 catalytic triad [active] 176279000146 peroxidatic and resolving cysteines [active] 176279000147 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 176279000148 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 176279000149 dimer interface [polypeptide binding]; other site 176279000150 FMN binding site [chemical binding]; other site 176279000151 NADPH bind site [chemical binding]; other site 176279000152 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 176279000153 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 176279000154 Heat induced stress protein YflT; Region: YflT; pfam11181 176279000155 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176279000156 active site 176279000157 xanthine permease; Region: pbuX; TIGR03173 176279000158 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 176279000159 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 176279000160 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 176279000161 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 176279000162 active site 176279000163 GMP synthase; Reviewed; Region: guaA; PRK00074 176279000164 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 176279000165 AMP/PPi binding site [chemical binding]; other site 176279000166 candidate oxyanion hole; other site 176279000167 catalytic triad [active] 176279000168 potential glutamine specificity residues [chemical binding]; other site 176279000169 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 176279000170 ATP Binding subdomain [chemical binding]; other site 176279000171 Ligand Binding sites [chemical binding]; other site 176279000172 Dimerization subdomain; other site 176279000173 Abi-like protein; Region: Abi_2; pfam07751 176279000174 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 176279000175 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 176279000176 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 176279000177 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 176279000178 dimer interface [polypeptide binding]; other site 176279000179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 176279000180 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 176279000181 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 176279000182 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 176279000183 similar to phenol soluble modulin alpha; identified by similarity to GP:3212077 176279000184 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 176279000185 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176279000186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 176279000187 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 176279000188 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 176279000189 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 176279000190 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 176279000191 active site 176279000192 Esterase/lipase [General function prediction only]; Region: COG1647 176279000193 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 176279000194 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 176279000195 Na2 binding site [ion binding]; other site 176279000196 putative substrate binding site 1 [chemical binding]; other site 176279000197 Na binding site 1 [ion binding]; other site 176279000198 putative substrate binding site 2 [chemical binding]; other site 176279000199 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 176279000200 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 176279000201 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 176279000202 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 176279000203 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 176279000204 dimer interface [polypeptide binding]; other site 176279000205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279000206 catalytic residue [active] 176279000207 cystathionine beta-lyase; Provisional; Region: PRK07671 176279000208 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 176279000209 homodimer interface [polypeptide binding]; other site 176279000210 substrate-cofactor binding pocket; other site 176279000211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279000212 catalytic residue [active] 176279000213 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 176279000214 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 176279000215 Walker A/P-loop; other site 176279000216 ATP binding site [chemical binding]; other site 176279000217 Q-loop/lid; other site 176279000218 ABC transporter signature motif; other site 176279000219 Walker B; other site 176279000220 D-loop; other site 176279000221 H-loop/switch region; other site 176279000222 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 176279000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279000224 dimer interface [polypeptide binding]; other site 176279000225 conserved gate region; other site 176279000226 ABC-ATPase subunit interface; other site 176279000227 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 176279000228 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 176279000229 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176279000230 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176279000231 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176279000232 Surface antigen [General function prediction only]; Region: COG3942 176279000233 CHAP domain; Region: CHAP; pfam05257 176279000234 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 176279000235 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 176279000236 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176279000237 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 176279000238 nudix motif; other site 176279000239 YibE/F-like protein; Region: YibE_F; cl02259 176279000240 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 176279000241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176279000242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176279000243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 176279000244 dimerization interface [polypeptide binding]; other site 176279000245 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 176279000246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 176279000247 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176279000248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176279000249 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 176279000250 dimerization interface [polypeptide binding]; other site 176279000251 Predicted membrane protein [Function unknown]; Region: COG2855 176279000252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279000253 Coenzyme A binding pocket [chemical binding]; other site 176279000254 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 176279000255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279000256 Walker A motif; other site 176279000257 ATP binding site [chemical binding]; other site 176279000258 Walker B motif; other site 176279000259 arginine finger; other site 176279000260 hypothetical protein; Validated; Region: PRK00153 176279000261 recombination protein RecR; Reviewed; Region: recR; PRK00076 176279000262 RecR protein; Region: RecR; pfam02132 176279000263 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 176279000264 putative active site [active] 176279000265 putative metal-binding site [ion binding]; other site 176279000266 tetramer interface [polypeptide binding]; other site 176279000267 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 176279000268 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 176279000269 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 176279000270 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 176279000271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176279000272 catalytic residue [active] 176279000273 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 176279000274 thymidylate kinase; Validated; Region: tmk; PRK00698 176279000275 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 176279000276 TMP-binding site; other site 176279000277 ATP-binding site [chemical binding]; other site 176279000278 Protein of unknown function (DUF970); Region: DUF970; pfam06153 176279000279 DNA polymerase III subunit delta'; Validated; Region: PRK08058 176279000280 DNA polymerase III subunit delta'; Validated; Region: PRK08485 176279000281 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 176279000282 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 176279000283 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 176279000284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279000285 S-adenosylmethionine binding site [chemical binding]; other site 176279000286 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 176279000287 GIY-YIG motif/motif A; other site 176279000288 putative active site [active] 176279000289 putative metal binding site [ion binding]; other site 176279000290 Predicted methyltransferases [General function prediction only]; Region: COG0313 176279000291 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 176279000292 putative SAM binding site [chemical binding]; other site 176279000293 putative homodimer interface [polypeptide binding]; other site 176279000294 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 176279000295 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 176279000296 active site 176279000297 HIGH motif; other site 176279000298 KMSKS motif; other site 176279000299 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 176279000300 tRNA binding surface [nucleotide binding]; other site 176279000301 anticodon binding site; other site 176279000302 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 176279000303 dimer interface [polypeptide binding]; other site 176279000304 putative tRNA-binding site [nucleotide binding]; other site 176279000305 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 176279000306 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 176279000307 active site 176279000308 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 176279000309 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 176279000310 putative active site [active] 176279000311 putative metal binding site [ion binding]; other site 176279000312 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 176279000313 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 176279000314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279000315 S-adenosylmethionine binding site [chemical binding]; other site 176279000316 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 176279000317 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 176279000318 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 176279000319 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 176279000320 pur operon repressor; Provisional; Region: PRK09213 176279000321 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 176279000322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176279000323 active site 176279000324 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 176279000325 homotrimer interaction site [polypeptide binding]; other site 176279000326 putative active site [active] 176279000327 regulatory protein SpoVG; Reviewed; Region: PRK13259 176279000328 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 176279000329 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 176279000330 Substrate binding site; other site 176279000331 Mg++ binding site; other site 176279000332 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 176279000333 active site 176279000334 substrate binding site [chemical binding]; other site 176279000335 CoA binding site [chemical binding]; other site 176279000336 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 176279000337 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 176279000338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176279000339 active site 176279000340 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 176279000341 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 176279000342 5S rRNA interface [nucleotide binding]; other site 176279000343 CTC domain interface [polypeptide binding]; other site 176279000344 L16 interface [polypeptide binding]; other site 176279000345 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 176279000346 putative active site [active] 176279000347 catalytic residue [active] 176279000348 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 176279000349 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 176279000350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176279000351 ATP binding site [chemical binding]; other site 176279000352 putative Mg++ binding site [ion binding]; other site 176279000353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279000354 nucleotide binding region [chemical binding]; other site 176279000355 ATP-binding site [chemical binding]; other site 176279000356 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 176279000357 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 176279000358 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 176279000359 putative SAM binding site [chemical binding]; other site 176279000360 putative homodimer interface [polypeptide binding]; other site 176279000361 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 176279000362 homodimer interface [polypeptide binding]; other site 176279000363 metal binding site [ion binding]; metal-binding site 176279000364 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176279000365 RNA binding surface [nucleotide binding]; other site 176279000366 Septum formation initiator; Region: DivIC; pfam04977 176279000367 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 176279000368 hypothetical protein; Provisional; Region: PRK08582 176279000369 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 176279000370 RNA binding site [nucleotide binding]; other site 176279000371 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 176279000372 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 176279000373 Ligand Binding Site [chemical binding]; other site 176279000374 TilS substrate C-terminal domain; Region: TilS_C; smart00977 176279000375 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 176279000376 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176279000377 active site 176279000378 FtsH Extracellular; Region: FtsH_ext; pfam06480 176279000379 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 176279000380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279000381 Walker A motif; other site 176279000382 ATP binding site [chemical binding]; other site 176279000383 Walker B motif; other site 176279000384 arginine finger; other site 176279000385 Peptidase family M41; Region: Peptidase_M41; pfam01434 176279000386 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 176279000387 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 176279000388 dimerization interface [polypeptide binding]; other site 176279000389 domain crossover interface; other site 176279000390 redox-dependent activation switch; other site 176279000391 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 176279000392 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 176279000393 dimer interface [polypeptide binding]; other site 176279000394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279000395 catalytic residue [active] 176279000396 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 176279000397 dihydropteroate synthase; Region: DHPS; TIGR01496 176279000398 substrate binding pocket [chemical binding]; other site 176279000399 dimer interface [polypeptide binding]; other site 176279000400 inhibitor binding site; inhibition site 176279000401 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 176279000402 homooctamer interface [polypeptide binding]; other site 176279000403 active site 176279000404 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 176279000405 catalytic center binding site [active] 176279000406 ATP binding site [chemical binding]; other site 176279000407 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 176279000408 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 176279000409 dimer interface [polypeptide binding]; other site 176279000410 putative anticodon binding site; other site 176279000411 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 176279000412 motif 1; other site 176279000413 active site 176279000414 motif 2; other site 176279000415 motif 3; other site 176279000416 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 176279000417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 176279000418 DNA-binding site [nucleotide binding]; DNA binding site 176279000419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 176279000420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279000421 homodimer interface [polypeptide binding]; other site 176279000422 catalytic residue [active] 176279000423 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 176279000424 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 176279000425 active site 176279000426 multimer interface [polypeptide binding]; other site 176279000427 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 176279000428 predicted active site [active] 176279000429 catalytic triad [active] 176279000430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279000431 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279000432 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 176279000433 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 176279000434 Nucleoside recognition; Region: Gate; pfam07670 176279000435 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 176279000436 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 176279000437 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 176279000438 UvrB/uvrC motif; Region: UVR; pfam02151 176279000439 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 176279000440 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 176279000441 ADP binding site [chemical binding]; other site 176279000442 phosphagen binding site; other site 176279000443 substrate specificity loop; other site 176279000444 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 176279000445 Clp amino terminal domain; Region: Clp_N; pfam02861 176279000446 Clp amino terminal domain; Region: Clp_N; pfam02861 176279000447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279000448 Walker A motif; other site 176279000449 ATP binding site [chemical binding]; other site 176279000450 Walker B motif; other site 176279000451 arginine finger; other site 176279000452 UvrB/uvrC motif; Region: UVR; pfam02151 176279000453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279000454 Walker A motif; other site 176279000455 ATP binding site [chemical binding]; other site 176279000456 Walker B motif; other site 176279000457 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 176279000458 DNA repair protein RadA; Provisional; Region: PRK11823 176279000459 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 176279000460 Walker A motif/ATP binding site; other site 176279000461 ATP binding site [chemical binding]; other site 176279000462 Walker B motif; other site 176279000463 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 176279000464 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 176279000465 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 176279000466 putative active site [active] 176279000467 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 176279000468 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 176279000469 active site 176279000470 HIGH motif; other site 176279000471 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 176279000472 active site 176279000473 KMSKS motif; other site 176279000474 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 176279000475 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 176279000476 trimer interface [polypeptide binding]; other site 176279000477 active site 176279000478 substrate binding site [chemical binding]; other site 176279000479 CoA binding site [chemical binding]; other site 176279000480 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 176279000481 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 176279000482 active site 176279000483 HIGH motif; other site 176279000484 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 176279000485 KMSKS motif; other site 176279000486 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 176279000487 tRNA binding surface [nucleotide binding]; other site 176279000488 anticodon binding site; other site 176279000489 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 176279000490 active site 176279000491 metal binding site [ion binding]; metal-binding site 176279000492 dimerization interface [polypeptide binding]; other site 176279000493 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 176279000494 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 176279000495 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 176279000496 YacP-like NYN domain; Region: NYN_YacP; cl01491 176279000497 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 176279000498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 176279000499 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 176279000500 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 176279000501 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 176279000502 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 176279000503 putative homodimer interface [polypeptide binding]; other site 176279000504 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 176279000505 heterodimer interface [polypeptide binding]; other site 176279000506 homodimer interface [polypeptide binding]; other site 176279000507 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 176279000508 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 176279000509 23S rRNA interface [nucleotide binding]; other site 176279000510 L7/L12 interface [polypeptide binding]; other site 176279000511 putative thiostrepton binding site; other site 176279000512 L25 interface [polypeptide binding]; other site 176279000513 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 176279000514 mRNA/rRNA interface [nucleotide binding]; other site 176279000515 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 176279000516 23S rRNA interface [nucleotide binding]; other site 176279000517 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 176279000518 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 176279000519 peripheral dimer interface [polypeptide binding]; other site 176279000520 core dimer interface [polypeptide binding]; other site 176279000521 L10 interface [polypeptide binding]; other site 176279000522 L11 interface [polypeptide binding]; other site 176279000523 putative EF-Tu interaction site [polypeptide binding]; other site 176279000524 putative EF-G interaction site [polypeptide binding]; other site 176279000525 Methyltransferase domain; Region: Methyltransf_31; pfam13847 176279000526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279000527 S-adenosylmethionine binding site [chemical binding]; other site 176279000528 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 176279000529 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 176279000530 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 176279000531 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 176279000532 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 176279000533 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 176279000534 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 176279000535 RPB10 interaction site [polypeptide binding]; other site 176279000536 RPB1 interaction site [polypeptide binding]; other site 176279000537 RPB11 interaction site [polypeptide binding]; other site 176279000538 RPB3 interaction site [polypeptide binding]; other site 176279000539 RPB12 interaction site [polypeptide binding]; other site 176279000540 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 176279000541 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 176279000542 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 176279000543 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 176279000544 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 176279000545 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 176279000546 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 176279000547 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 176279000548 G-loop; other site 176279000549 DNA binding site [nucleotide binding] 176279000550 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 176279000551 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 176279000552 S17 interaction site [polypeptide binding]; other site 176279000553 S8 interaction site; other site 176279000554 16S rRNA interaction site [nucleotide binding]; other site 176279000555 streptomycin interaction site [chemical binding]; other site 176279000556 23S rRNA interaction site [nucleotide binding]; other site 176279000557 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 176279000558 30S ribosomal protein S7; Validated; Region: PRK05302 176279000559 elongation factor G; Reviewed; Region: PRK00007 176279000560 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 176279000561 G1 box; other site 176279000562 putative GEF interaction site [polypeptide binding]; other site 176279000563 GTP/Mg2+ binding site [chemical binding]; other site 176279000564 Switch I region; other site 176279000565 G2 box; other site 176279000566 G3 box; other site 176279000567 Switch II region; other site 176279000568 G4 box; other site 176279000569 G5 box; other site 176279000570 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 176279000571 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 176279000572 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 176279000573 elongation factor Tu; Reviewed; Region: PRK00049 176279000574 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 176279000575 G1 box; other site 176279000576 GEF interaction site [polypeptide binding]; other site 176279000577 GTP/Mg2+ binding site [chemical binding]; other site 176279000578 Switch I region; other site 176279000579 G2 box; other site 176279000580 G3 box; other site 176279000581 Switch II region; other site 176279000582 G4 box; other site 176279000583 G5 box; other site 176279000584 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 176279000585 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 176279000586 Antibiotic Binding Site [chemical binding]; other site 176279000587 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176279000588 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 176279000589 metal binding site [ion binding]; metal-binding site 176279000590 dimer interface [polypeptide binding]; other site 176279000591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 176279000592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279000593 Coenzyme A binding pocket [chemical binding]; other site 176279000594 ornithine cyclodeaminase; Validated; Region: PRK08618 176279000595 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 176279000596 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 176279000597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176279000598 NAD(P) binding site [chemical binding]; other site 176279000599 active site 176279000600 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 176279000601 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 176279000602 homodimer interface [polypeptide binding]; other site 176279000603 substrate-cofactor binding pocket; other site 176279000604 catalytic residue [active] 176279000605 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 176279000606 substrate binding site; other site 176279000607 dimer interface; other site 176279000608 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 176279000609 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 176279000610 NAD(P) binding site [chemical binding]; other site 176279000611 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176279000612 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 176279000613 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 176279000614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279000615 motif II; other site 176279000616 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 176279000617 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 176279000618 active site 176279000619 non-prolyl cis peptide bond; other site 176279000620 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 176279000621 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 176279000622 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 176279000623 putative NAD(P) binding site [chemical binding]; other site 176279000624 active site 176279000625 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 176279000626 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 176279000627 Substrate-binding site [chemical binding]; other site 176279000628 Substrate specificity [chemical binding]; other site 176279000629 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 176279000630 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 176279000631 Substrate-binding site [chemical binding]; other site 176279000632 Substrate specificity [chemical binding]; other site 176279000633 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 176279000634 nucleoside/Zn binding site; other site 176279000635 dimer interface [polypeptide binding]; other site 176279000636 catalytic motif [active] 176279000637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279000638 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 176279000639 active site 176279000640 motif I; other site 176279000641 motif II; other site 176279000642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279000643 Predicted flavoprotein [General function prediction only]; Region: COG0431 176279000644 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 176279000645 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 176279000646 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 176279000647 Cna protein B-type domain; Region: Cna_B; pfam05738 176279000648 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 176279000649 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 176279000650 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176279000651 Low molecular weight phosphatase family; Region: LMWPc; cd00115 176279000652 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 176279000653 active site 176279000654 arsenical pump membrane protein; Provisional; Region: PRK15445 176279000655 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 176279000656 transmembrane helices; other site 176279000657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176279000658 dimerization interface [polypeptide binding]; other site 176279000659 putative DNA binding site [nucleotide binding]; other site 176279000660 putative Zn2+ binding site [ion binding]; other site 176279000661 putative GTP cyclohydrolase; Provisional; Region: PRK13674 176279000662 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 176279000663 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 176279000664 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 176279000665 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 176279000666 active site 176279000667 trimer interface [polypeptide binding]; other site 176279000668 allosteric site; other site 176279000669 active site lid [active] 176279000670 hexamer (dimer of trimers) interface [polypeptide binding]; other site 176279000671 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 176279000672 active site 176279000673 dimer interface [polypeptide binding]; other site 176279000674 magnesium binding site [ion binding]; other site 176279000675 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 176279000676 tetramer interface [polypeptide binding]; other site 176279000677 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 176279000678 active site 176279000679 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 176279000680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279000681 motif II; other site 176279000682 acyl-CoA synthetase; Validated; Region: PRK07638 176279000683 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 176279000684 acyl-activating enzyme (AAE) consensus motif; other site 176279000685 AMP binding site [chemical binding]; other site 176279000686 active site 176279000687 CoA binding site [chemical binding]; other site 176279000688 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 176279000689 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 176279000690 dimer interface [polypeptide binding]; other site 176279000691 active site 176279000692 proline/glycine betaine transporter; Provisional; Region: PRK10642 176279000693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279000694 putative substrate translocation pore; other site 176279000695 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 176279000696 dimer interface [polypeptide binding]; other site 176279000697 substrate binding site [chemical binding]; other site 176279000698 ATP binding site [chemical binding]; other site 176279000699 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 176279000700 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 176279000701 active site 176279000702 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 176279000703 ligand binding site [chemical binding]; other site 176279000704 active site 176279000705 UGI interface [polypeptide binding]; other site 176279000706 catalytic site [active] 176279000707 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 176279000708 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 176279000709 Uncharacterized conserved protein [Function unknown]; Region: COG3610 176279000710 Uncharacterized conserved protein [Function unknown]; Region: COG2966 176279000711 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 176279000712 putative heme peroxidase; Provisional; Region: PRK12276 176279000713 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 176279000714 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 176279000715 mevalonate kinase; Region: mevalon_kin; TIGR00549 176279000716 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 176279000717 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 176279000718 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 176279000719 diphosphomevalonate decarboxylase; Region: PLN02407 176279000720 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 176279000721 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 176279000722 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 176279000723 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 176279000724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279000725 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176279000726 Predicted transcriptional regulator [Transcription]; Region: COG1959 176279000727 Transcriptional regulator; Region: Rrf2; pfam02082 176279000728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 176279000729 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 176279000730 active site 176279000731 catalytic tetrad [active] 176279000732 MMPL family; Region: MMPL; pfam03176 176279000733 Protein export membrane protein; Region: SecD_SecF; cl14618 176279000734 MMPL family; Region: MMPL; pfam03176 176279000735 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 176279000736 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 176279000737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 176279000738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176279000739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176279000740 Integrase core domain; Region: rve; pfam00665 176279000741 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 176279000742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279000743 Coenzyme A binding pocket [chemical binding]; other site 176279000744 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 176279000745 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176279000746 Zn2+ binding site [ion binding]; other site 176279000747 Mg2+ binding site [ion binding]; other site 176279000748 YwhD family; Region: YwhD; pfam08741 176279000749 hypothetical protein; Provisional; Region: PRK04194 176279000750 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 176279000751 AIR carboxylase; Region: AIRC; smart01001 176279000752 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 176279000753 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 176279000754 Ligand Binding Site [chemical binding]; other site 176279000755 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 176279000756 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 176279000757 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 176279000758 NAD binding site [chemical binding]; other site 176279000759 substrate binding site [chemical binding]; other site 176279000760 catalytic Zn binding site [ion binding]; other site 176279000761 tetramer interface [polypeptide binding]; other site 176279000762 structural Zn binding site [ion binding]; other site 176279000763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279000764 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279000765 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 176279000766 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 176279000767 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 176279000768 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 176279000769 active site 176279000770 HIGH motif; other site 176279000771 KMSK motif region; other site 176279000772 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 176279000773 tRNA binding surface [nucleotide binding]; other site 176279000774 anticodon binding site; other site 176279000775 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 176279000776 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 176279000777 minor groove reading motif; other site 176279000778 helix-hairpin-helix signature motif; other site 176279000779 substrate binding pocket [chemical binding]; other site 176279000780 active site 176279000781 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 176279000782 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 176279000783 DNA binding residues [nucleotide binding] 176279000784 dimer interface [polypeptide binding]; other site 176279000785 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 176279000786 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 176279000787 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 176279000788 putative binding site residues; other site 176279000789 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 176279000790 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176279000791 putative PBP binding regions; other site 176279000792 ABC-ATPase subunit interface; other site 176279000793 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 176279000794 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 176279000795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279000796 motif II; other site 176279000797 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 176279000798 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 176279000799 PGAP1-like protein; Region: PGAP1; pfam07819 176279000800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 176279000801 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 176279000802 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176279000803 Transcriptional regulators [Transcription]; Region: MarR; COG1846 176279000804 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 176279000805 HlyD family secretion protein; Region: HlyD_3; pfam13437 176279000806 Protein of unknown function, DUF606; Region: DUF606; pfam04657 176279000807 Protein of unknown function, DUF606; Region: DUF606; pfam04657 176279000808 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 176279000809 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 176279000810 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 176279000811 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176279000812 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 176279000813 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 176279000814 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 176279000815 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 176279000816 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176279000817 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 176279000818 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 176279000819 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 176279000820 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 176279000821 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 176279000822 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 176279000823 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 176279000824 metal binding site [ion binding]; metal-binding site 176279000825 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 176279000826 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176279000827 ABC-ATPase subunit interface; other site 176279000828 dimer interface [polypeptide binding]; other site 176279000829 putative PBP binding regions; other site 176279000830 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 176279000831 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 176279000832 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 176279000833 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 176279000834 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 176279000835 FeoA domain; Region: FeoA; pfam04023 176279000836 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 176279000837 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 176279000838 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 176279000839 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 176279000840 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 176279000841 Walker A/P-loop; other site 176279000842 ATP binding site [chemical binding]; other site 176279000843 Q-loop/lid; other site 176279000844 ABC transporter signature motif; other site 176279000845 Walker B; other site 176279000846 D-loop; other site 176279000847 H-loop/switch region; other site 176279000848 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 176279000849 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176279000850 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 176279000851 active site 176279000852 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 176279000853 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 176279000854 active site 176279000855 nucleotide binding site [chemical binding]; other site 176279000856 HIGH motif; other site 176279000857 KMSKS motif; other site 176279000858 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 176279000859 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 176279000860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279000861 Walker A/P-loop; other site 176279000862 ATP binding site [chemical binding]; other site 176279000863 Q-loop/lid; other site 176279000864 ABC transporter signature motif; other site 176279000865 Walker B; other site 176279000866 D-loop; other site 176279000867 H-loop/switch region; other site 176279000868 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 176279000869 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 176279000870 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 176279000871 Uncharacterized conserved protein [Function unknown]; Region: COG1284 176279000872 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 176279000873 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 176279000874 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 176279000875 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 176279000876 Walker A/P-loop; other site 176279000877 ATP binding site [chemical binding]; other site 176279000878 Q-loop/lid; other site 176279000879 ABC transporter signature motif; other site 176279000880 Walker B; other site 176279000881 D-loop; other site 176279000882 H-loop/switch region; other site 176279000883 Uncharacterized membrane protein [Function unknown]; Region: COG3949 176279000884 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 176279000885 Na binding site [ion binding]; other site 176279000886 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 176279000887 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 176279000888 substrate binding pocket [chemical binding]; other site 176279000889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 176279000890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279000891 Coenzyme A binding pocket [chemical binding]; other site 176279000892 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 176279000893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176279000894 NAD(P) binding site [chemical binding]; other site 176279000895 active site 176279000896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176279000897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279000898 active site 176279000899 phosphorylation site [posttranslational modification] 176279000900 intermolecular recognition site; other site 176279000901 dimerization interface [polypeptide binding]; other site 176279000902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176279000903 DNA binding site [nucleotide binding] 176279000904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176279000905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 176279000906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279000907 ATP binding site [chemical binding]; other site 176279000908 Mg2+ binding site [ion binding]; other site 176279000909 G-X-G motif; other site 176279000910 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176279000911 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176279000912 Walker A/P-loop; other site 176279000913 ATP binding site [chemical binding]; other site 176279000914 Q-loop/lid; other site 176279000915 ABC transporter signature motif; other site 176279000916 Walker B; other site 176279000917 D-loop; other site 176279000918 H-loop/switch region; other site 176279000919 FtsX-like permease family; Region: FtsX; pfam02687 176279000920 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 176279000921 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 176279000922 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176279000923 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 176279000924 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176279000925 Surface antigen [General function prediction only]; Region: COG3942 176279000926 CHAP domain; Region: CHAP; pfam05257 176279000927 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 176279000928 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176279000929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 176279000930 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176279000931 hypothetical protein; Provisional; Region: PRK12378 176279000932 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 176279000933 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 176279000934 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 176279000935 Hemerythrin-like domain; Region: Hr-like; cd12108 176279000936 Fe binding site [ion binding]; other site 176279000937 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 176279000938 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 176279000939 heme-binding site [chemical binding]; other site 176279000940 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 176279000941 FAD binding pocket [chemical binding]; other site 176279000942 FAD binding motif [chemical binding]; other site 176279000943 phosphate binding motif [ion binding]; other site 176279000944 beta-alpha-beta structure motif; other site 176279000945 NAD binding pocket [chemical binding]; other site 176279000946 Heme binding pocket [chemical binding]; other site 176279000947 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 176279000948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176279000949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176279000950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 176279000951 dimerization interface [polypeptide binding]; other site 176279000952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279000953 sugar efflux transporter; Region: 2A0120; TIGR00899 176279000954 putative substrate translocation pore; other site 176279000955 Protein of unknown function (DUF456); Region: DUF456; pfam04306 176279000956 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 176279000957 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 176279000958 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 176279000959 hypothetical protein; Validated; Region: PRK00124 176279000960 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 176279000961 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 176279000962 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 176279000963 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 176279000964 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 176279000965 Walker A/P-loop; other site 176279000966 ATP binding site [chemical binding]; other site 176279000967 Q-loop/lid; other site 176279000968 ABC transporter signature motif; other site 176279000969 Walker B; other site 176279000970 D-loop; other site 176279000971 H-loop/switch region; other site 176279000972 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 176279000973 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 176279000974 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 176279000975 Walker A/P-loop; other site 176279000976 ATP binding site [chemical binding]; other site 176279000977 Q-loop/lid; other site 176279000978 ABC transporter signature motif; other site 176279000979 Walker B; other site 176279000980 D-loop; other site 176279000981 H-loop/switch region; other site 176279000982 Transcriptional regulators [Transcription]; Region: MarR; COG1846 176279000983 MarR family; Region: MarR; pfam01047 176279000984 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 176279000985 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 176279000986 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 176279000987 malate dehydrogenase; Reviewed; Region: PRK06223 176279000988 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 176279000989 NAD(P) binding site [chemical binding]; other site 176279000990 dimer interface [polypeptide binding]; other site 176279000991 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176279000992 substrate binding site [chemical binding]; other site 176279000993 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 176279000994 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 176279000995 transmembrane helices; other site 176279000996 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 176279000997 DNA photolyase; Region: DNA_photolyase; pfam00875 176279000998 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 176279000999 D-galactonate transporter; Region: 2A0114; TIGR00893 176279001000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279001001 putative substrate translocation pore; other site 176279001002 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 176279001003 putative deacylase active site [active] 176279001004 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 176279001005 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 176279001006 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 176279001007 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 176279001008 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 176279001009 putative substrate binding site [chemical binding]; other site 176279001010 putative ATP binding site [chemical binding]; other site 176279001011 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 176279001012 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 176279001013 active site 176279001014 phosphorylation site [posttranslational modification] 176279001015 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 176279001016 active site 176279001017 P-loop; other site 176279001018 phosphorylation site [posttranslational modification] 176279001019 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 176279001020 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 176279001021 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 176279001022 active site 176279001023 dimer interface [polypeptide binding]; other site 176279001024 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 176279001025 Domain of unknown function DUF21; Region: DUF21; pfam01595 176279001026 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 176279001027 Transporter associated domain; Region: CorC_HlyC; smart01091 176279001028 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 176279001029 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 176279001030 active site 176279001031 catalytic tetrad [active] 176279001032 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 176279001033 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 176279001034 Ligand binding site; other site 176279001035 Putative Catalytic site; other site 176279001036 DXD motif; other site 176279001037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176279001038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176279001039 dimer interface [polypeptide binding]; other site 176279001040 phosphorylation site [posttranslational modification] 176279001041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279001042 ATP binding site [chemical binding]; other site 176279001043 Mg2+ binding site [ion binding]; other site 176279001044 G-X-G motif; other site 176279001045 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176279001046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279001047 active site 176279001048 phosphorylation site [posttranslational modification] 176279001049 intermolecular recognition site; other site 176279001050 dimerization interface [polypeptide binding]; other site 176279001051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176279001052 DNA binding site [nucleotide binding] 176279001053 Predicted membrane protein [Function unknown]; Region: COG2259 176279001054 Electron transfer DM13; Region: DM13; pfam10517 176279001055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 176279001056 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 176279001057 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 176279001058 active site 176279001059 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 176279001060 Ligand Binding Site [chemical binding]; other site 176279001061 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 176279001062 Glutamine amidotransferase class-I; Region: GATase; pfam00117 176279001063 glutamine binding [chemical binding]; other site 176279001064 catalytic triad [active] 176279001065 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 176279001066 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 176279001067 Sulfatase; Region: Sulfatase; pfam00884 176279001068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279001069 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279001070 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 176279001071 ZIP Zinc transporter; Region: Zip; pfam02535 176279001072 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 176279001073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279001074 Walker A/P-loop; other site 176279001075 ATP binding site [chemical binding]; other site 176279001076 Q-loop/lid; other site 176279001077 ABC transporter signature motif; other site 176279001078 Walker B; other site 176279001079 D-loop; other site 176279001080 H-loop/switch region; other site 176279001081 ABC transporter; Region: ABC_tran_2; pfam12848 176279001082 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176279001083 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 176279001084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176279001085 ATP binding site [chemical binding]; other site 176279001086 putative Mg++ binding site [ion binding]; other site 176279001087 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279001088 nucleotide binding region [chemical binding]; other site 176279001089 ATP-binding site [chemical binding]; other site 176279001090 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 176279001091 HRDC domain; Region: HRDC; pfam00570 176279001092 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 176279001093 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 176279001094 Walker A/P-loop; other site 176279001095 ATP binding site [chemical binding]; other site 176279001096 Q-loop/lid; other site 176279001097 ABC transporter signature motif; other site 176279001098 Walker B; other site 176279001099 D-loop; other site 176279001100 H-loop/switch region; other site 176279001101 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 176279001102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279001103 dimer interface [polypeptide binding]; other site 176279001104 conserved gate region; other site 176279001105 ABC-ATPase subunit interface; other site 176279001106 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 176279001107 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 176279001108 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 176279001109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 176279001110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279001111 homodimer interface [polypeptide binding]; other site 176279001112 catalytic residue [active] 176279001113 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 176279001114 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 176279001115 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 176279001116 putative catalytic cysteine [active] 176279001117 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 176279001118 putative active site [active] 176279001119 metal binding site [ion binding]; metal-binding site 176279001120 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 176279001121 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 176279001122 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 176279001123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279001124 putative substrate translocation pore; other site 176279001125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279001126 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 176279001127 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 176279001128 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 176279001129 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 176279001130 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 176279001131 Class I ribonucleotide reductase; Region: RNR_I; cd01679 176279001132 active site 176279001133 dimer interface [polypeptide binding]; other site 176279001134 catalytic residues [active] 176279001135 effector binding site; other site 176279001136 R2 peptide binding site; other site 176279001137 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 176279001138 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 176279001139 dimer interface [polypeptide binding]; other site 176279001140 putative radical transfer pathway; other site 176279001141 diiron center [ion binding]; other site 176279001142 tyrosyl radical; other site 176279001143 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176279001144 ABC-ATPase subunit interface; other site 176279001145 dimer interface [polypeptide binding]; other site 176279001146 putative PBP binding regions; other site 176279001147 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176279001148 ABC-ATPase subunit interface; other site 176279001149 dimer interface [polypeptide binding]; other site 176279001150 putative PBP binding regions; other site 176279001151 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 176279001152 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 176279001153 Walker A/P-loop; other site 176279001154 ATP binding site [chemical binding]; other site 176279001155 Q-loop/lid; other site 176279001156 ABC transporter signature motif; other site 176279001157 Walker B; other site 176279001158 D-loop; other site 176279001159 H-loop/switch region; other site 176279001160 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 176279001161 putative ligand binding residues [chemical binding]; other site 176279001162 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 176279001163 CHY zinc finger; Region: zf-CHY; pfam05495 176279001164 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 176279001165 FAD binding domain; Region: FAD_binding_4; pfam01565 176279001166 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 176279001167 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 176279001168 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 176279001169 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 176279001170 peptidase T; Region: peptidase-T; TIGR01882 176279001171 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 176279001172 metal binding site [ion binding]; metal-binding site 176279001173 dimer interface [polypeptide binding]; other site 176279001174 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 176279001175 Uncharacterized conserved protein [Function unknown]; Region: COG2966 176279001176 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 176279001177 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 176279001178 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 176279001179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 176279001180 metal binding site [ion binding]; metal-binding site 176279001181 active site 176279001182 I-site; other site 176279001183 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 176279001184 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 176279001185 Mg++ binding site [ion binding]; other site 176279001186 putative catalytic motif [active] 176279001187 substrate binding site [chemical binding]; other site 176279001188 Uncharacterized conserved protein [Function unknown]; Region: COG1739 176279001189 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 176279001190 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 176279001191 EDD domain protein, DegV family; Region: DegV; TIGR00762 176279001192 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 176279001193 DEAD-like helicases superfamily; Region: DEXDc; smart00487 176279001194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176279001195 ATP binding site [chemical binding]; other site 176279001196 putative Mg++ binding site [ion binding]; other site 176279001197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279001198 nucleotide binding region [chemical binding]; other site 176279001199 ATP-binding site [chemical binding]; other site 176279001200 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 176279001201 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176279001202 active site 176279001203 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 176279001204 30S subunit binding site; other site 176279001205 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 176279001206 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 176279001207 SEC-C motif; Region: SEC-C; pfam02810 176279001208 peptide chain release factor 2; Validated; Region: prfB; PRK00578 176279001209 This domain is found in peptide chain release factors; Region: PCRF; smart00937 176279001210 RF-1 domain; Region: RF-1; pfam00472 176279001211 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 176279001212 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176279001213 CHAP domain; Region: CHAP; pfam05257 176279001214 Surface antigen [General function prediction only]; Region: COG3942 176279001215 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176279001216 Zn2+ binding site [ion binding]; other site 176279001217 Mg2+ binding site [ion binding]; other site 176279001218 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 176279001219 excinuclease ABC subunit B; Provisional; Region: PRK05298 176279001220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176279001221 ATP binding site [chemical binding]; other site 176279001222 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279001223 nucleotide binding region [chemical binding]; other site 176279001224 ATP-binding site [chemical binding]; other site 176279001225 Ultra-violet resistance protein B; Region: UvrB; pfam12344 176279001226 UvrB/uvrC motif; Region: UVR; pfam02151 176279001227 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 176279001228 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 176279001229 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 176279001230 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 176279001231 HPr kinase/phosphorylase; Provisional; Region: PRK05428 176279001232 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 176279001233 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 176279001234 Hpr binding site; other site 176279001235 active site 176279001236 homohexamer subunit interaction site [polypeptide binding]; other site 176279001237 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 176279001238 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 176279001239 trimer interface [polypeptide binding]; other site 176279001240 active site 176279001241 substrate binding site [chemical binding]; other site 176279001242 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 176279001243 CoA binding site [chemical binding]; other site 176279001244 TPR repeat; Region: TPR_11; pfam13414 176279001245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176279001246 binding surface 176279001247 TPR motif; other site 176279001248 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 176279001249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176279001250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279001251 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 176279001252 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 176279001253 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 176279001254 phosphate binding site [ion binding]; other site 176279001255 dimer interface [polypeptide binding]; other site 176279001256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 176279001257 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 176279001258 Clp protease; Region: CLP_protease; pfam00574 176279001259 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 176279001260 oligomer interface [polypeptide binding]; other site 176279001261 active site residues [active] 176279001262 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 176279001263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176279001264 NAD(P) binding site [chemical binding]; other site 176279001265 active site 176279001266 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 176279001267 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 176279001268 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 176279001269 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 176279001270 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 176279001271 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 176279001272 Phosphoglycerate kinase; Region: PGK; pfam00162 176279001273 substrate binding site [chemical binding]; other site 176279001274 hinge regions; other site 176279001275 ADP binding site [chemical binding]; other site 176279001276 catalytic site [active] 176279001277 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 176279001278 triosephosphate isomerase; Provisional; Region: PRK14565 176279001279 substrate binding site [chemical binding]; other site 176279001280 dimer interface [polypeptide binding]; other site 176279001281 catalytic triad [active] 176279001282 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 176279001283 phosphoglyceromutase; Provisional; Region: PRK05434 176279001284 enolase; Provisional; Region: eno; PRK00077 176279001285 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 176279001286 dimer interface [polypeptide binding]; other site 176279001287 metal binding site [ion binding]; metal-binding site 176279001288 substrate binding pocket [chemical binding]; other site 176279001289 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 176279001290 Esterase/lipase [General function prediction only]; Region: COG1647 176279001291 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 176279001292 ribonuclease R; Region: RNase_R; TIGR02063 176279001293 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 176279001294 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 176279001295 RNB domain; Region: RNB; pfam00773 176279001296 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 176279001297 RNA binding site [nucleotide binding]; other site 176279001298 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 176279001299 SmpB-tmRNA interface; other site 176279001300 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 176279001301 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 176279001302 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 176279001303 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 176279001304 active site 176279001305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 176279001306 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 176279001307 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 176279001308 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 176279001309 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 176279001310 DNA-binding site [nucleotide binding]; DNA binding site 176279001311 RNA-binding motif; other site 176279001312 Protein of unknown function (DUF867); Region: DUF867; pfam05908 176279001313 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 176279001314 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 176279001315 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 176279001316 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 176279001317 catalytic core [active] 176279001318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 176279001319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 176279001320 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 176279001321 Coenzyme A binding pocket [chemical binding]; other site 176279001322 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 176279001323 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 176279001324 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 176279001325 active site 176279001326 catalytic residue [active] 176279001327 dimer interface [polypeptide binding]; other site 176279001328 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 176279001329 putative FMN binding site [chemical binding]; other site 176279001330 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176279001331 catalytic residues [active] 176279001332 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 176279001333 ArsC family; Region: ArsC; pfam03960 176279001334 putative ArsC-like catalytic residues; other site 176279001335 putative TRX-like catalytic residues [active] 176279001336 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 176279001337 lipoyl attachment site [posttranslational modification]; other site 176279001338 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 176279001339 putative active site [active] 176279001340 putative metal binding site [ion binding]; other site 176279001341 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176279001342 catalytic residues [active] 176279001343 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 176279001344 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 176279001345 Walker A/P-loop; other site 176279001346 ATP binding site [chemical binding]; other site 176279001347 Q-loop/lid; other site 176279001348 ABC transporter signature motif; other site 176279001349 Walker B; other site 176279001350 D-loop; other site 176279001351 H-loop/switch region; other site 176279001352 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 176279001353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279001354 dimer interface [polypeptide binding]; other site 176279001355 conserved gate region; other site 176279001356 ABC-ATPase subunit interface; other site 176279001357 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 176279001358 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 176279001359 Predicted membrane protein [Function unknown]; Region: COG2035 176279001360 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 176279001361 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 176279001362 Walker A/P-loop; other site 176279001363 ATP binding site [chemical binding]; other site 176279001364 Q-loop/lid; other site 176279001365 ABC transporter signature motif; other site 176279001366 Walker B; other site 176279001367 D-loop; other site 176279001368 H-loop/switch region; other site 176279001369 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 176279001370 FeS assembly protein SufD; Region: sufD; TIGR01981 176279001371 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 176279001372 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 176279001373 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176279001374 catalytic residue [active] 176279001375 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 176279001376 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 176279001377 trimerization site [polypeptide binding]; other site 176279001378 active site 176279001379 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 176279001380 FeS assembly protein SufB; Region: sufB; TIGR01980 176279001381 Domain of unknown function DUF21; Region: DUF21; pfam01595 176279001382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 176279001383 Protein of unknown function DUF72; Region: DUF72; pfam01904 176279001384 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 176279001385 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 176279001386 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 176279001387 active site 176279001388 metal binding site [ion binding]; metal-binding site 176279001389 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 176279001390 lipoyl synthase; Provisional; Region: PRK05481 176279001391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279001392 FeS/SAM binding site; other site 176279001393 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 176279001394 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 176279001395 Uncharacterized conserved protein [Function unknown]; Region: COG2445 176279001396 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 176279001397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279001398 active site 176279001399 motif I; other site 176279001400 motif II; other site 176279001401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279001402 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 176279001403 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 176279001404 dimerization interface [polypeptide binding]; other site 176279001405 ligand binding site [chemical binding]; other site 176279001406 NADP binding site [chemical binding]; other site 176279001407 catalytic site [active] 176279001408 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 176279001409 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 176279001410 acyl-activating enzyme (AAE) consensus motif; other site 176279001411 AMP binding site [chemical binding]; other site 176279001412 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 176279001413 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 176279001414 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 176279001415 DltD N-terminal region; Region: DltD_N; pfam04915 176279001416 DltD central region; Region: DltD_M; pfam04918 176279001417 DltD C-terminal region; Region: DltD_C; pfam04914 176279001418 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 176279001419 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 176279001420 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 176279001421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279001422 hypothetical protein; Provisional; Region: PRK13669 176279001423 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 176279001424 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 176279001425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279001426 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 176279001427 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 176279001428 interface (dimer of trimers) [polypeptide binding]; other site 176279001429 Substrate-binding/catalytic site; other site 176279001430 Zn-binding sites [ion binding]; other site 176279001431 Predicted permease [General function prediction only]; Region: COG2056 176279001432 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 176279001433 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 176279001434 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 176279001435 CoenzymeA binding site [chemical binding]; other site 176279001436 subunit interaction site [polypeptide binding]; other site 176279001437 PHB binding site; other site 176279001438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176279001439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176279001440 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 176279001441 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 176279001442 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 176279001443 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 176279001444 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176279001445 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 176279001446 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 176279001447 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 176279001448 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 176279001449 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 176279001450 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 176279001451 Kinase associated protein B; Region: KapB; pfam08810 176279001452 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 176279001453 active site 176279001454 general stress protein 13; Validated; Region: PRK08059 176279001455 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 176279001456 RNA binding site [nucleotide binding]; other site 176279001457 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 176279001458 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 176279001459 putative active site [active] 176279001460 putative FMN binding site [chemical binding]; other site 176279001461 putative substrate binding site [chemical binding]; other site 176279001462 putative catalytic residue [active] 176279001463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279001464 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279001465 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 176279001466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176279001467 inhibitor-cofactor binding pocket; inhibition site 176279001468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279001469 catalytic residue [active] 176279001470 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 176279001471 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 176279001472 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 176279001473 NAD(P) binding site [chemical binding]; other site 176279001474 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 176279001475 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 176279001476 active site 176279001477 catalytic site [active] 176279001478 metal binding site [ion binding]; metal-binding site 176279001479 argininosuccinate lyase; Provisional; Region: PRK00855 176279001480 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 176279001481 active sites [active] 176279001482 tetramer interface [polypeptide binding]; other site 176279001483 argininosuccinate synthase; Provisional; Region: PRK13820 176279001484 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 176279001485 ANP binding site [chemical binding]; other site 176279001486 Substrate Binding Site II [chemical binding]; other site 176279001487 Substrate Binding Site I [chemical binding]; other site 176279001488 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 176279001489 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 176279001490 active site 176279001491 dimer interface [polypeptide binding]; other site 176279001492 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 176279001493 dimer interface [polypeptide binding]; other site 176279001494 active site 176279001495 Uncharacterized conserved protein [Function unknown]; Region: COG0398 176279001496 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 176279001497 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 176279001498 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 176279001499 Catalytic site [active] 176279001500 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 176279001501 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 176279001502 Catalytic site [active] 176279001503 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 176279001504 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 176279001505 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 176279001506 Family description; Region: UvrD_C_2; pfam13538 176279001507 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 176279001508 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 176279001509 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 176279001510 hypothetical protein; Provisional; Region: PRK13673 176279001511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279001512 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279001513 coenzyme A disulfide reductase; Provisional; Region: PRK13512 176279001514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176279001515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279001516 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176279001517 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 176279001518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279001519 active site 176279001520 motif I; other site 176279001521 motif II; other site 176279001522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279001523 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 176279001524 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 176279001525 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 176279001526 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 176279001527 catalytic triad [active] 176279001528 catalytic triad [active] 176279001529 oxyanion hole [active] 176279001530 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 176279001531 Clp amino terminal domain; Region: Clp_N; pfam02861 176279001532 Clp amino terminal domain; Region: Clp_N; pfam02861 176279001533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279001534 Walker A motif; other site 176279001535 ATP binding site [chemical binding]; other site 176279001536 Walker B motif; other site 176279001537 arginine finger; other site 176279001538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279001539 Walker A motif; other site 176279001540 ATP binding site [chemical binding]; other site 176279001541 Walker B motif; other site 176279001542 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 176279001543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279001544 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279001545 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 176279001546 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 176279001547 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 176279001548 dimer interface [polypeptide binding]; other site 176279001549 active site 176279001550 CoA binding pocket [chemical binding]; other site 176279001551 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 176279001552 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 176279001553 dimer interface [polypeptide binding]; other site 176279001554 active site 176279001555 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 176279001556 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 176279001557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279001558 dimer interface [polypeptide binding]; other site 176279001559 conserved gate region; other site 176279001560 putative PBP binding loops; other site 176279001561 ABC-ATPase subunit interface; other site 176279001562 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 176279001563 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 176279001564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279001565 dimer interface [polypeptide binding]; other site 176279001566 conserved gate region; other site 176279001567 putative PBP binding loops; other site 176279001568 ABC-ATPase subunit interface; other site 176279001569 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 176279001570 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176279001571 Walker A/P-loop; other site 176279001572 ATP binding site [chemical binding]; other site 176279001573 Q-loop/lid; other site 176279001574 ABC transporter signature motif; other site 176279001575 Walker B; other site 176279001576 D-loop; other site 176279001577 H-loop/switch region; other site 176279001578 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 176279001579 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 176279001580 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176279001581 Walker A/P-loop; other site 176279001582 ATP binding site [chemical binding]; other site 176279001583 Q-loop/lid; other site 176279001584 ABC transporter signature motif; other site 176279001585 Walker B; other site 176279001586 D-loop; other site 176279001587 H-loop/switch region; other site 176279001588 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 176279001589 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 176279001590 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 176279001591 peptide binding site [polypeptide binding]; other site 176279001592 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 176279001593 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 176279001594 active site 176279001595 HIGH motif; other site 176279001596 dimer interface [polypeptide binding]; other site 176279001597 KMSKS motif; other site 176279001598 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 176279001599 ArsC family; Region: ArsC; pfam03960 176279001600 putative catalytic residues [active] 176279001601 thiol/disulfide switch; other site 176279001602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279001603 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279001604 adaptor protein; Provisional; Region: PRK02315 176279001605 Competence protein CoiA-like family; Region: CoiA; pfam06054 176279001606 oligoendopeptidase F; Region: pepF; TIGR00181 176279001607 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 176279001608 active site 176279001609 Zn binding site [ion binding]; other site 176279001610 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 176279001611 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 176279001612 catalytic residues [active] 176279001613 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 176279001614 apolar tunnel; other site 176279001615 heme binding site [chemical binding]; other site 176279001616 dimerization interface [polypeptide binding]; other site 176279001617 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 176279001618 putative active site [active] 176279001619 putative metal binding residues [ion binding]; other site 176279001620 signature motif; other site 176279001621 putative triphosphate binding site [ion binding]; other site 176279001622 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 176279001623 synthetase active site [active] 176279001624 NTP binding site [chemical binding]; other site 176279001625 metal binding site [ion binding]; metal-binding site 176279001626 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 176279001627 ATP-NAD kinase; Region: NAD_kinase; pfam01513 176279001628 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 176279001629 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 176279001630 active site 176279001631 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 176279001632 MgtE intracellular N domain; Region: MgtE_N; smart00924 176279001633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 176279001634 Divalent cation transporter; Region: MgtE; pfam01769 176279001635 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 176279001636 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 176279001637 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 176279001638 TrkA-N domain; Region: TrkA_N; pfam02254 176279001639 TrkA-C domain; Region: TrkA_C; pfam02080 176279001640 Protein of unknown function (DUF443); Region: DUF443; pfam04276 176279001641 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 176279001642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279001643 Walker A/P-loop; other site 176279001644 ATP binding site [chemical binding]; other site 176279001645 Q-loop/lid; other site 176279001646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279001647 ABC transporter signature motif; other site 176279001648 Walker B; other site 176279001649 D-loop; other site 176279001650 H-loop/switch region; other site 176279001651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279001652 AAA domain; Region: AAA_21; pfam13304 176279001653 Walker A/P-loop; other site 176279001654 ATP binding site [chemical binding]; other site 176279001655 Q-loop/lid; other site 176279001656 ABC transporter signature motif; other site 176279001657 Walker B; other site 176279001658 D-loop; other site 176279001659 H-loop/switch region; other site 176279001660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 176279001661 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 176279001662 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 176279001663 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 176279001664 NAD binding site [chemical binding]; other site 176279001665 homotetramer interface [polypeptide binding]; other site 176279001666 homodimer interface [polypeptide binding]; other site 176279001667 substrate binding site [chemical binding]; other site 176279001668 active site 176279001669 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 176279001670 Domain of unknown function DUF20; Region: UPF0118; pfam01594 176279001671 Putative esterase; Region: Esterase; pfam00756 176279001672 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 176279001673 hypothetical protein; Provisional; Region: PRK13679 176279001674 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 176279001675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279001676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279001677 putative substrate translocation pore; other site 176279001678 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 176279001679 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 176279001680 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 176279001681 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 176279001682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 176279001683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176279001684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176279001685 YueH-like protein; Region: YueH; pfam14166 176279001686 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 176279001687 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 176279001688 G1 box; other site 176279001689 putative GEF interaction site [polypeptide binding]; other site 176279001690 GTP/Mg2+ binding site [chemical binding]; other site 176279001691 Switch I region; other site 176279001692 G2 box; other site 176279001693 G3 box; other site 176279001694 Switch II region; other site 176279001695 G4 box; other site 176279001696 G5 box; other site 176279001697 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 176279001698 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 176279001699 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 176279001700 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 176279001701 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 176279001702 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 176279001703 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 176279001704 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 176279001705 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 176279001706 active site 176279001707 metal binding site [ion binding]; metal-binding site 176279001708 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 176279001709 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 176279001710 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 176279001711 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 176279001712 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 176279001713 ComK protein; Region: ComK; cl11560 176279001714 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 176279001715 Fatty acid desaturase; Region: FA_desaturase; pfam00487 176279001716 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 176279001717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279001718 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 176279001719 Coenzyme A binding pocket [chemical binding]; other site 176279001720 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 176279001721 UbiA prenyltransferase family; Region: UbiA; pfam01040 176279001722 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 176279001723 isochorismate synthases; Region: isochor_syn; TIGR00543 176279001724 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 176279001725 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 176279001726 dimer interface [polypeptide binding]; other site 176279001727 tetramer interface [polypeptide binding]; other site 176279001728 PYR/PP interface [polypeptide binding]; other site 176279001729 TPP binding site [chemical binding]; other site 176279001730 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 176279001731 TPP-binding site; other site 176279001732 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 176279001733 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 176279001734 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 176279001735 substrate binding site [chemical binding]; other site 176279001736 oxyanion hole (OAH) forming residues; other site 176279001737 trimer interface [polypeptide binding]; other site 176279001738 aminotransferase A; Validated; Region: PRK07683 176279001739 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 176279001740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279001741 homodimer interface [polypeptide binding]; other site 176279001742 catalytic residue [active] 176279001743 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 176279001744 Acyltransferase family; Region: Acyl_transf_3; pfam01757 176279001745 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176279001746 MarR family; Region: MarR; pfam01047 176279001747 MarR family; Region: MarR_2; cl17246 176279001748 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 176279001749 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 176279001750 amidase catalytic site [active] 176279001751 Zn binding residues [ion binding]; other site 176279001752 substrate binding site [chemical binding]; other site 176279001753 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 176279001754 Lysozyme subfamily 2; Region: LYZ2; smart00047 176279001755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279001756 Coenzyme A binding pocket [chemical binding]; other site 176279001757 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 176279001758 Transcriptional regulator [Transcription]; Region: LytR; COG1316 176279001759 Beta-lactamase; Region: Beta-lactamase; pfam00144 176279001760 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 176279001761 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 176279001762 active site 176279001763 tetramer interface [polypeptide binding]; other site 176279001764 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 176279001765 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 176279001766 Subunit I/III interface [polypeptide binding]; other site 176279001767 Subunit III/IV interface [polypeptide binding]; other site 176279001768 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 176279001769 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 176279001770 D-pathway; other site 176279001771 Putative ubiquinol binding site [chemical binding]; other site 176279001772 Low-spin heme (heme b) binding site [chemical binding]; other site 176279001773 Putative water exit pathway; other site 176279001774 Binuclear center (heme o3/CuB) [ion binding]; other site 176279001775 K-pathway; other site 176279001776 Putative proton exit pathway; other site 176279001777 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 176279001778 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 176279001779 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 176279001780 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 176279001781 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 176279001782 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 176279001783 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 176279001784 homodimer interface [polypeptide binding]; other site 176279001785 NADP binding site [chemical binding]; other site 176279001786 substrate binding site [chemical binding]; other site 176279001787 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 176279001788 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 176279001789 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 176279001790 NAD binding site [chemical binding]; other site 176279001791 ATP-grasp domain; Region: ATP-grasp; pfam02222 176279001792 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 176279001793 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 176279001794 ATP binding site [chemical binding]; other site 176279001795 active site 176279001796 substrate binding site [chemical binding]; other site 176279001797 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 176279001798 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 176279001799 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 176279001800 putative active site [active] 176279001801 catalytic triad [active] 176279001802 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 176279001803 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 176279001804 dimerization interface [polypeptide binding]; other site 176279001805 ATP binding site [chemical binding]; other site 176279001806 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 176279001807 dimerization interface [polypeptide binding]; other site 176279001808 ATP binding site [chemical binding]; other site 176279001809 amidophosphoribosyltransferase; Provisional; Region: PRK07272 176279001810 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 176279001811 active site 176279001812 tetramer interface [polypeptide binding]; other site 176279001813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176279001814 active site 176279001815 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 176279001816 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 176279001817 dimerization interface [polypeptide binding]; other site 176279001818 putative ATP binding site [chemical binding]; other site 176279001819 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 176279001820 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 176279001821 active site 176279001822 substrate binding site [chemical binding]; other site 176279001823 cosubstrate binding site; other site 176279001824 catalytic site [active] 176279001825 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 176279001826 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 176279001827 purine monophosphate binding site [chemical binding]; other site 176279001828 dimer interface [polypeptide binding]; other site 176279001829 putative catalytic residues [active] 176279001830 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 176279001831 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 176279001832 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 176279001833 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 176279001834 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 176279001835 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 176279001836 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 176279001837 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 176279001838 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 176279001839 Walker A/P-loop; other site 176279001840 ATP binding site [chemical binding]; other site 176279001841 Q-loop/lid; other site 176279001842 ABC transporter signature motif; other site 176279001843 Walker B; other site 176279001844 D-loop; other site 176279001845 H-loop/switch region; other site 176279001846 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 176279001847 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 176279001848 Walker A/P-loop; other site 176279001849 ATP binding site [chemical binding]; other site 176279001850 Q-loop/lid; other site 176279001851 ABC transporter signature motif; other site 176279001852 Walker B; other site 176279001853 D-loop; other site 176279001854 H-loop/switch region; other site 176279001855 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 176279001856 myosin-cross-reactive antigen; Provisional; Region: PRK13977 176279001857 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 176279001858 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 176279001859 putative RNA binding site [nucleotide binding]; other site 176279001860 Methyltransferase domain; Region: Methyltransf_26; pfam13659 176279001861 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 176279001862 dimerization domain swap beta strand [polypeptide binding]; other site 176279001863 regulatory protein interface [polypeptide binding]; other site 176279001864 active site 176279001865 regulatory phosphorylation site [posttranslational modification]; other site 176279001866 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 176279001867 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 176279001868 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 176279001869 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 176279001870 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 176279001871 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 176279001872 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 176279001873 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 176279001874 TrkA-N domain; Region: TrkA_N; pfam02254 176279001875 TrkA-C domain; Region: TrkA_C; pfam02080 176279001876 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 176279001877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 176279001878 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 176279001879 hypothetical protein; Provisional; Region: PRK13667 176279001880 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 176279001881 active site 176279001882 catalytic residues [active] 176279001883 metal binding site [ion binding]; metal-binding site 176279001884 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 176279001885 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 176279001886 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 176279001887 TPP-binding site [chemical binding]; other site 176279001888 tetramer interface [polypeptide binding]; other site 176279001889 heterodimer interface [polypeptide binding]; other site 176279001890 phosphorylation loop region [posttranslational modification] 176279001891 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 176279001892 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 176279001893 alpha subunit interface [polypeptide binding]; other site 176279001894 TPP binding site [chemical binding]; other site 176279001895 heterodimer interface [polypeptide binding]; other site 176279001896 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 176279001897 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 176279001898 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 176279001899 E3 interaction surface; other site 176279001900 lipoyl attachment site [posttranslational modification]; other site 176279001901 e3 binding domain; Region: E3_binding; pfam02817 176279001902 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 176279001903 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 176279001904 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 176279001905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279001906 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176279001907 hypothetical protein; Provisional; Region: PRK04387 176279001908 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 176279001909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176279001910 non-specific DNA binding site [nucleotide binding]; other site 176279001911 salt bridge; other site 176279001912 sequence-specific DNA binding site [nucleotide binding]; other site 176279001913 Cupin domain; Region: Cupin_2; pfam07883 176279001914 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 176279001915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279001916 Walker A/P-loop; other site 176279001917 ATP binding site [chemical binding]; other site 176279001918 Q-loop/lid; other site 176279001919 ABC transporter signature motif; other site 176279001920 Walker B; other site 176279001921 D-loop; other site 176279001922 H-loop/switch region; other site 176279001923 TOBE domain; Region: TOBE_2; pfam08402 176279001924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279001925 dimer interface [polypeptide binding]; other site 176279001926 conserved gate region; other site 176279001927 putative PBP binding loops; other site 176279001928 ABC-ATPase subunit interface; other site 176279001929 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 176279001930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279001931 dimer interface [polypeptide binding]; other site 176279001932 conserved gate region; other site 176279001933 putative PBP binding loops; other site 176279001934 ABC-ATPase subunit interface; other site 176279001935 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 176279001936 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 176279001937 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 176279001938 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 176279001939 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 176279001940 manganese transport protein MntH; Reviewed; Region: PRK00701 176279001941 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 176279001942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 176279001943 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 176279001944 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 176279001945 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 176279001946 active site 176279001947 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 176279001948 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 176279001949 G1 box; other site 176279001950 putative GEF interaction site [polypeptide binding]; other site 176279001951 GTP/Mg2+ binding site [chemical binding]; other site 176279001952 Switch I region; other site 176279001953 G2 box; other site 176279001954 G3 box; other site 176279001955 Switch II region; other site 176279001956 G4 box; other site 176279001957 G5 box; other site 176279001958 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 176279001959 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 176279001960 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279001961 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279001962 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 176279001963 hypothetical protein; Provisional; Region: PRK13666 176279001964 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 176279001965 pyruvate carboxylase; Reviewed; Region: PRK12999 176279001966 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176279001967 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 176279001968 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 176279001969 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 176279001970 active site 176279001971 catalytic residues [active] 176279001972 metal binding site [ion binding]; metal-binding site 176279001973 homodimer binding site [polypeptide binding]; other site 176279001974 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 176279001975 carboxyltransferase (CT) interaction site; other site 176279001976 biotinylation site [posttranslational modification]; other site 176279001977 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 176279001978 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 176279001979 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 176279001980 UbiA prenyltransferase family; Region: UbiA; pfam01040 176279001981 Protein of unknown function (DUF420); Region: DUF420; pfam04238 176279001982 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 176279001983 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 176279001984 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 176279001985 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 176279001986 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 176279001987 putative active site [active] 176279001988 catalytic site [active] 176279001989 putative metal binding site [ion binding]; other site 176279001990 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 176279001991 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 176279001992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279001993 S-adenosylmethionine binding site [chemical binding]; other site 176279001994 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 176279001995 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 176279001996 active site 176279001997 (T/H)XGH motif; other site 176279001998 hypothetical protein; Provisional; Region: PRK13670 176279001999 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 176279002000 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 176279002001 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 176279002002 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176279002003 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 176279002004 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 176279002005 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 176279002006 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 176279002007 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 176279002008 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 176279002009 dimer interface [polypeptide binding]; other site 176279002010 motif 1; other site 176279002011 active site 176279002012 motif 2; other site 176279002013 motif 3; other site 176279002014 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 176279002015 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 176279002016 putative tRNA-binding site [nucleotide binding]; other site 176279002017 B3/4 domain; Region: B3_4; pfam03483 176279002018 tRNA synthetase B5 domain; Region: B5; smart00874 176279002019 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 176279002020 dimer interface [polypeptide binding]; other site 176279002021 motif 1; other site 176279002022 motif 3; other site 176279002023 motif 2; other site 176279002024 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 176279002025 ribonuclease HIII; Provisional; Region: PRK00996 176279002026 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 176279002027 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 176279002028 RNA/DNA hybrid binding site [nucleotide binding]; other site 176279002029 active site 176279002030 Cell division protein ZapA; Region: ZapA; cl01146 176279002031 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 176279002032 Colicin V production protein; Region: Colicin_V; pfam02674 176279002033 hypothetical protein; Provisional; Region: PRK08609 176279002034 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 176279002035 active site 176279002036 primer binding site [nucleotide binding]; other site 176279002037 NTP binding site [chemical binding]; other site 176279002038 metal binding triad [ion binding]; metal-binding site 176279002039 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 176279002040 active site 176279002041 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 176279002042 MutS domain III; Region: MutS_III; pfam05192 176279002043 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 176279002044 Walker A/P-loop; other site 176279002045 ATP binding site [chemical binding]; other site 176279002046 Q-loop/lid; other site 176279002047 ABC transporter signature motif; other site 176279002048 Walker B; other site 176279002049 D-loop; other site 176279002050 H-loop/switch region; other site 176279002051 Smr domain; Region: Smr; pfam01713 176279002052 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176279002053 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 176279002054 catalytic residues [active] 176279002055 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 176279002056 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 176279002057 GIY-YIG motif/motif A; other site 176279002058 active site 176279002059 catalytic site [active] 176279002060 putative DNA binding site [nucleotide binding]; other site 176279002061 metal binding site [ion binding]; metal-binding site 176279002062 UvrB/uvrC motif; Region: UVR; pfam02151 176279002063 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 176279002064 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 176279002065 putative Iron-sulfur protein interface [polypeptide binding]; other site 176279002066 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 176279002067 proximal heme binding site [chemical binding]; other site 176279002068 distal heme binding site [chemical binding]; other site 176279002069 putative dimer interface [polypeptide binding]; other site 176279002070 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 176279002071 L-aspartate oxidase; Provisional; Region: PRK06175 176279002072 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 176279002073 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 176279002074 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 176279002075 glutamate racemase; Provisional; Region: PRK00865 176279002076 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 176279002077 active site 176279002078 dimerization interface [polypeptide binding]; other site 176279002079 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 176279002080 active site 176279002081 metal binding site [ion binding]; metal-binding site 176279002082 homotetramer interface [polypeptide binding]; other site 176279002083 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176279002084 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176279002085 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176279002086 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176279002087 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 176279002088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279002089 motif II; other site 176279002090 hypothetical protein; Provisional; Region: PRK13688 176279002091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279002092 Coenzyme A binding pocket [chemical binding]; other site 176279002093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 176279002094 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 176279002095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 176279002096 MraZ protein; Region: MraZ; pfam02381 176279002097 MraZ protein; Region: MraZ; pfam02381 176279002098 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 176279002099 MraW methylase family; Region: Methyltransf_5; pfam01795 176279002100 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 176279002101 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 176279002102 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 176279002103 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 176279002104 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 176279002105 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 176279002106 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 176279002107 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 176279002108 Mg++ binding site [ion binding]; other site 176279002109 putative catalytic motif [active] 176279002110 putative substrate binding site [chemical binding]; other site 176279002111 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 176279002112 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176279002113 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176279002114 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 176279002115 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 176279002116 Cell division protein FtsQ; Region: FtsQ; pfam03799 176279002117 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 176279002118 Cell division protein FtsA; Region: FtsA; smart00842 176279002119 Cell division protein FtsA; Region: FtsA; pfam14450 176279002120 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 176279002121 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 176279002122 nucleotide binding site [chemical binding]; other site 176279002123 SulA interaction site; other site 176279002124 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 176279002125 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 176279002126 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 176279002127 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176279002128 catalytic residue [active] 176279002129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 176279002130 YGGT family; Region: YGGT; pfam02325 176279002131 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 176279002132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176279002133 RNA binding surface [nucleotide binding]; other site 176279002134 DivIVA protein; Region: DivIVA; pfam05103 176279002135 DivIVA domain; Region: DivI1A_domain; TIGR03544 176279002136 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 176279002137 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 176279002138 HIGH motif; other site 176279002139 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 176279002140 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 176279002141 active site 176279002142 KMSKS motif; other site 176279002143 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 176279002144 tRNA binding surface [nucleotide binding]; other site 176279002145 anticodon binding site; other site 176279002146 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 176279002147 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 176279002148 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 176279002149 active site 176279002150 Surface antigen [General function prediction only]; Region: COG3942 176279002151 CHAP domain; Region: CHAP; pfam05257 176279002152 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 176279002153 lipoprotein signal peptidase; Provisional; Region: PRK14787 176279002154 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 176279002155 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176279002156 RNA binding surface [nucleotide binding]; other site 176279002157 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 176279002158 active site 176279002159 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 176279002160 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 176279002161 uracil transporter; Provisional; Region: PRK10720 176279002162 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 176279002163 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 176279002164 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 176279002165 dihydroorotase; Validated; Region: pyrC; PRK09357 176279002166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 176279002167 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 176279002168 active site 176279002169 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 176279002170 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 176279002171 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 176279002172 catalytic site [active] 176279002173 subunit interface [polypeptide binding]; other site 176279002174 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 176279002175 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176279002176 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 176279002177 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 176279002178 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176279002179 ATP-grasp domain; Region: ATP-grasp_4; cl17255 176279002180 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 176279002181 IMP binding site; other site 176279002182 dimer interface [polypeptide binding]; other site 176279002183 interdomain contacts; other site 176279002184 partial ornithine binding site; other site 176279002185 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 176279002186 active site 176279002187 dimer interface [polypeptide binding]; other site 176279002188 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176279002189 active site 176279002190 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 176279002191 dimer interface [polypeptide binding]; other site 176279002192 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 176279002193 Domain of unknown function (DUF814); Region: DUF814; pfam05670 176279002194 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 176279002195 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 176279002196 catalytic site [active] 176279002197 G-X2-G-X-G-K; other site 176279002198 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 176279002199 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 176279002200 Flavoprotein; Region: Flavoprotein; pfam02441 176279002201 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 176279002202 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 176279002203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176279002204 ATP binding site [chemical binding]; other site 176279002205 putative Mg++ binding site [ion binding]; other site 176279002206 helicase superfamily c-terminal domain; Region: HELICc; smart00490 176279002207 nucleotide binding region [chemical binding]; other site 176279002208 ATP-binding site [chemical binding]; other site 176279002209 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 176279002210 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 176279002211 active site 176279002212 catalytic residues [active] 176279002213 metal binding site [ion binding]; metal-binding site 176279002214 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 176279002215 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 176279002216 putative active site [active] 176279002217 substrate binding site [chemical binding]; other site 176279002218 putative cosubstrate binding site; other site 176279002219 catalytic site [active] 176279002220 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 176279002221 substrate binding site [chemical binding]; other site 176279002222 16S rRNA methyltransferase B; Provisional; Region: PRK14902 176279002223 NusB family; Region: NusB; pfam01029 176279002224 putative RNA binding site [nucleotide binding]; other site 176279002225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279002226 S-adenosylmethionine binding site [chemical binding]; other site 176279002227 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 176279002228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279002229 FeS/SAM binding site; other site 176279002230 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 176279002231 Protein phosphatase 2C; Region: PP2C; pfam00481 176279002232 active site 176279002233 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 176279002234 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 176279002235 active site 176279002236 ATP binding site [chemical binding]; other site 176279002237 substrate binding site [chemical binding]; other site 176279002238 activation loop (A-loop); other site 176279002239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 176279002240 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 176279002241 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 176279002242 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 176279002243 GTPase RsgA; Reviewed; Region: PRK00098 176279002244 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 176279002245 RNA binding site [nucleotide binding]; other site 176279002246 homodimer interface [polypeptide binding]; other site 176279002247 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 176279002248 GTPase/Zn-binding domain interface [polypeptide binding]; other site 176279002249 GTP/Mg2+ binding site [chemical binding]; other site 176279002250 G4 box; other site 176279002251 G5 box; other site 176279002252 G1 box; other site 176279002253 Switch I region; other site 176279002254 G2 box; other site 176279002255 G3 box; other site 176279002256 Switch II region; other site 176279002257 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 176279002258 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 176279002259 substrate binding site [chemical binding]; other site 176279002260 hexamer interface [polypeptide binding]; other site 176279002261 metal binding site [ion binding]; metal-binding site 176279002262 Thiamine pyrophosphokinase; Region: TPK; cd07995 176279002263 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 176279002264 active site 176279002265 dimerization interface [polypeptide binding]; other site 176279002266 thiamine binding site [chemical binding]; other site 176279002267 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 176279002268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 176279002269 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 176279002270 DAK2 domain; Region: Dak2; pfam02734 176279002271 RimM N-terminal domain; Region: RimM; pfam01782 176279002272 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 176279002273 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 176279002274 generic binding surface II; other site 176279002275 ssDNA binding site; other site 176279002276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176279002277 ATP binding site [chemical binding]; other site 176279002278 putative Mg++ binding site [ion binding]; other site 176279002279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279002280 nucleotide binding region [chemical binding]; other site 176279002281 ATP-binding site [chemical binding]; other site 176279002282 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 176279002283 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 176279002284 putative phosphate acyltransferase; Provisional; Region: PRK05331 176279002285 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 176279002286 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 176279002287 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 176279002288 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 176279002289 NAD(P) binding site [chemical binding]; other site 176279002290 homotetramer interface [polypeptide binding]; other site 176279002291 homodimer interface [polypeptide binding]; other site 176279002292 active site 176279002293 acyl carrier protein; Provisional; Region: acpP; PRK00982 176279002294 ribonuclease III; Reviewed; Region: rnc; PRK00102 176279002295 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 176279002296 dimerization interface [polypeptide binding]; other site 176279002297 active site 176279002298 metal binding site [ion binding]; metal-binding site 176279002299 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 176279002300 dsRNA binding site [nucleotide binding]; other site 176279002301 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 176279002302 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 176279002303 Walker A/P-loop; other site 176279002304 ATP binding site [chemical binding]; other site 176279002305 Q-loop/lid; other site 176279002306 Mis12-Mtw1 protein family; Region: Mis12_component; pfam08202 176279002307 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 176279002308 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 176279002309 ABC transporter signature motif; other site 176279002310 Walker B; other site 176279002311 D-loop; other site 176279002312 H-loop/switch region; other site 176279002313 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 176279002314 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 176279002315 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 176279002316 P loop; other site 176279002317 GTP binding site [chemical binding]; other site 176279002318 putative DNA-binding protein; Validated; Region: PRK00118 176279002319 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 176279002320 signal recognition particle protein; Provisional; Region: PRK10867 176279002321 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 176279002322 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 176279002323 P loop; other site 176279002324 GTP binding site [chemical binding]; other site 176279002325 Signal peptide binding domain; Region: SRP_SPB; pfam02978 176279002326 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 176279002327 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 176279002328 RimM N-terminal domain; Region: RimM; pfam01782 176279002329 PRC-barrel domain; Region: PRC; pfam05239 176279002330 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 176279002331 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 176279002332 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 176279002333 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 176279002334 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 176279002335 GTP/Mg2+ binding site [chemical binding]; other site 176279002336 G4 box; other site 176279002337 G5 box; other site 176279002338 G1 box; other site 176279002339 Switch I region; other site 176279002340 G2 box; other site 176279002341 G3 box; other site 176279002342 Switch II region; other site 176279002343 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 176279002344 RNA/DNA hybrid binding site [nucleotide binding]; other site 176279002345 active site 176279002346 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 176279002347 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 176279002348 CoA-ligase; Region: Ligase_CoA; pfam00549 176279002349 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 176279002350 CoA binding domain; Region: CoA_binding; smart00881 176279002351 CoA-ligase; Region: Ligase_CoA; pfam00549 176279002352 DNA protecting protein DprA; Region: dprA; TIGR00732 176279002353 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 176279002354 DNA topoisomerase I; Validated; Region: PRK05582 176279002355 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 176279002356 active site 176279002357 interdomain interaction site; other site 176279002358 putative metal-binding site [ion binding]; other site 176279002359 nucleotide binding site [chemical binding]; other site 176279002360 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 176279002361 domain I; other site 176279002362 DNA binding groove [nucleotide binding] 176279002363 phosphate binding site [ion binding]; other site 176279002364 domain II; other site 176279002365 domain III; other site 176279002366 nucleotide binding site [chemical binding]; other site 176279002367 catalytic site [active] 176279002368 domain IV; other site 176279002369 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 176279002370 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 176279002371 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 176279002372 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 176279002373 Glucose inhibited division protein A; Region: GIDA; pfam01134 176279002374 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 176279002375 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 176279002376 active site 176279002377 DNA binding site [nucleotide binding] 176279002378 Int/Topo IB signature motif; other site 176279002379 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 176279002380 active site 176279002381 HslU subunit interaction site [polypeptide binding]; other site 176279002382 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 176279002383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279002384 Walker A motif; other site 176279002385 ATP binding site [chemical binding]; other site 176279002386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279002387 Walker B motif; other site 176279002388 arginine finger; other site 176279002389 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 176279002390 transcriptional repressor CodY; Validated; Region: PRK04158 176279002391 CodY GAF-like domain; Region: CodY; pfam06018 176279002392 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 176279002393 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 176279002394 rRNA interaction site [nucleotide binding]; other site 176279002395 S8 interaction site; other site 176279002396 putative laminin-1 binding site; other site 176279002397 elongation factor Ts; Provisional; Region: tsf; PRK09377 176279002398 UBA/TS-N domain; Region: UBA; pfam00627 176279002399 Elongation factor TS; Region: EF_TS; pfam00889 176279002400 Elongation factor TS; Region: EF_TS; pfam00889 176279002401 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 176279002402 putative nucleotide binding site [chemical binding]; other site 176279002403 uridine monophosphate binding site [chemical binding]; other site 176279002404 homohexameric interface [polypeptide binding]; other site 176279002405 ribosome recycling factor; Reviewed; Region: frr; PRK00083 176279002406 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 176279002407 hinge region; other site 176279002408 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 176279002409 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 176279002410 catalytic residue [active] 176279002411 putative FPP diphosphate binding site; other site 176279002412 putative FPP binding hydrophobic cleft; other site 176279002413 dimer interface [polypeptide binding]; other site 176279002414 putative IPP diphosphate binding site; other site 176279002415 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 176279002416 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 176279002417 RIP metalloprotease RseP; Region: TIGR00054 176279002418 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 176279002419 active site 176279002420 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 176279002421 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 176279002422 protein binding site [polypeptide binding]; other site 176279002423 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 176279002424 putative substrate binding region [chemical binding]; other site 176279002425 prolyl-tRNA synthetase; Provisional; Region: PRK09194 176279002426 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 176279002427 dimer interface [polypeptide binding]; other site 176279002428 motif 1; other site 176279002429 active site 176279002430 motif 2; other site 176279002431 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 176279002432 putative deacylase active site [active] 176279002433 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 176279002434 active site 176279002435 motif 3; other site 176279002436 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 176279002437 anticodon binding site; other site 176279002438 DNA polymerase III PolC; Validated; Region: polC; PRK00448 176279002439 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 176279002440 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 176279002441 generic binding surface II; other site 176279002442 generic binding surface I; other site 176279002443 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 176279002444 active site 176279002445 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 176279002446 active site 176279002447 catalytic site [active] 176279002448 substrate binding site [chemical binding]; other site 176279002449 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 176279002450 ribosome maturation protein RimP; Reviewed; Region: PRK00092 176279002451 Sm and related proteins; Region: Sm_like; cl00259 176279002452 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 176279002453 putative oligomer interface [polypeptide binding]; other site 176279002454 putative RNA binding site [nucleotide binding]; other site 176279002455 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 176279002456 NusA N-terminal domain; Region: NusA_N; pfam08529 176279002457 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 176279002458 RNA binding site [nucleotide binding]; other site 176279002459 homodimer interface [polypeptide binding]; other site 176279002460 NusA-like KH domain; Region: KH_5; pfam13184 176279002461 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 176279002462 G-X-X-G motif; other site 176279002463 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 176279002464 putative RNA binding cleft [nucleotide binding]; other site 176279002465 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 176279002466 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 176279002467 translation initiation factor IF-2; Region: IF-2; TIGR00487 176279002468 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 176279002469 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 176279002470 G1 box; other site 176279002471 putative GEF interaction site [polypeptide binding]; other site 176279002472 GTP/Mg2+ binding site [chemical binding]; other site 176279002473 Switch I region; other site 176279002474 G2 box; other site 176279002475 G3 box; other site 176279002476 Switch II region; other site 176279002477 G4 box; other site 176279002478 G5 box; other site 176279002479 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 176279002480 Translation-initiation factor 2; Region: IF-2; pfam11987 176279002481 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 176279002482 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 176279002483 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 176279002484 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 176279002485 RNA binding site [nucleotide binding]; other site 176279002486 active site 176279002487 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 176279002488 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 176279002489 active site 176279002490 Riboflavin kinase; Region: Flavokinase; smart00904 176279002491 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 176279002492 16S/18S rRNA binding site [nucleotide binding]; other site 176279002493 S13e-L30e interaction site [polypeptide binding]; other site 176279002494 25S rRNA binding site [nucleotide binding]; other site 176279002495 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 176279002496 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 176279002497 RNase E interface [polypeptide binding]; other site 176279002498 trimer interface [polypeptide binding]; other site 176279002499 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 176279002500 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 176279002501 RNase E interface [polypeptide binding]; other site 176279002502 trimer interface [polypeptide binding]; other site 176279002503 active site 176279002504 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 176279002505 putative nucleic acid binding region [nucleotide binding]; other site 176279002506 G-X-X-G motif; other site 176279002507 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 176279002508 RNA binding site [nucleotide binding]; other site 176279002509 domain interface; other site 176279002510 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 176279002511 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 176279002512 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 176279002513 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 176279002514 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 176279002515 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 176279002516 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 176279002517 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 176279002518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 176279002519 DNA-binding site [nucleotide binding]; DNA binding site 176279002520 UTRA domain; Region: UTRA; pfam07702 176279002521 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 176279002522 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 176279002523 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 176279002524 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 176279002525 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 176279002526 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 176279002527 classical (c) SDRs; Region: SDR_c; cd05233 176279002528 NAD(P) binding site [chemical binding]; other site 176279002529 active site 176279002530 ACT domain; Region: ACT; pfam01842 176279002531 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 176279002532 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 176279002533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176279002534 non-specific DNA binding site [nucleotide binding]; other site 176279002535 salt bridge; other site 176279002536 sequence-specific DNA binding site [nucleotide binding]; other site 176279002537 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 176279002538 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 176279002539 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 176279002540 putative MPT binding site; other site 176279002541 recombinase A; Provisional; Region: recA; PRK09354 176279002542 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 176279002543 hexamer interface [polypeptide binding]; other site 176279002544 Walker A motif; other site 176279002545 ATP binding site [chemical binding]; other site 176279002546 Walker B motif; other site 176279002547 phosphodiesterase; Provisional; Region: PRK12704 176279002548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176279002549 Zn2+ binding site [ion binding]; other site 176279002550 Mg2+ binding site [ion binding]; other site 176279002551 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 176279002552 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 176279002553 putative active site [active] 176279002554 metal binding site [ion binding]; metal-binding site 176279002555 homodimer binding site [polypeptide binding]; other site 176279002556 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 176279002557 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 176279002558 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 176279002559 dimer interface [polypeptide binding]; other site 176279002560 PYR/PP interface [polypeptide binding]; other site 176279002561 TPP binding site [chemical binding]; other site 176279002562 substrate binding site [chemical binding]; other site 176279002563 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 176279002564 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 176279002565 TPP-binding site [chemical binding]; other site 176279002566 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 176279002567 Protein of unknown function (DUF867); Region: DUF867; pfam05908 176279002568 Uncharacterized conserved protein [Function unknown]; Region: COG0011 176279002569 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 176279002570 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 176279002571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279002572 FeS/SAM binding site; other site 176279002573 TRAM domain; Region: TRAM; pfam01938 176279002574 Predicted membrane protein [Function unknown]; Region: COG4550 176279002575 thiW protein; Region: thiW; TIGR02359 176279002576 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 176279002577 MutS domain I; Region: MutS_I; pfam01624 176279002578 MutS domain II; Region: MutS_II; pfam05188 176279002579 MutS domain III; Region: MutS_III; pfam05192 176279002580 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 176279002581 Walker A/P-loop; other site 176279002582 ATP binding site [chemical binding]; other site 176279002583 Q-loop/lid; other site 176279002584 ABC transporter signature motif; other site 176279002585 Walker B; other site 176279002586 D-loop; other site 176279002587 H-loop/switch region; other site 176279002588 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 176279002589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279002590 ATP binding site [chemical binding]; other site 176279002591 Mg2+ binding site [ion binding]; other site 176279002592 G-X-G motif; other site 176279002593 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 176279002594 ATP binding site [chemical binding]; other site 176279002595 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 176279002596 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 176279002597 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 176279002598 amphipathic channel; other site 176279002599 Asn-Pro-Ala signature motifs; other site 176279002600 glycerol kinase; Provisional; Region: glpK; PRK00047 176279002601 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 176279002602 N- and C-terminal domain interface [polypeptide binding]; other site 176279002603 active site 176279002604 MgATP binding site [chemical binding]; other site 176279002605 catalytic site [active] 176279002606 metal binding site [ion binding]; metal-binding site 176279002607 glycerol binding site [chemical binding]; other site 176279002608 homotetramer interface [polypeptide binding]; other site 176279002609 homodimer interface [polypeptide binding]; other site 176279002610 FBP binding site [chemical binding]; other site 176279002611 protein IIAGlc interface [polypeptide binding]; other site 176279002612 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 176279002613 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 176279002614 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 176279002615 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 176279002616 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 176279002617 bacterial Hfq-like; Region: Hfq; cd01716 176279002618 hexamer interface [polypeptide binding]; other site 176279002619 Sm1 motif; other site 176279002620 RNA binding site [nucleotide binding]; other site 176279002621 Sm2 motif; other site 176279002622 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 176279002623 catalytic residues [active] 176279002624 dimer interface [polypeptide binding]; other site 176279002625 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 176279002626 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 176279002627 HflX GTPase family; Region: HflX; cd01878 176279002628 G1 box; other site 176279002629 GTP/Mg2+ binding site [chemical binding]; other site 176279002630 Switch I region; other site 176279002631 G2 box; other site 176279002632 G3 box; other site 176279002633 Switch II region; other site 176279002634 G4 box; other site 176279002635 G5 box; other site 176279002636 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 176279002637 Aluminium resistance protein; Region: Alum_res; pfam06838 176279002638 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 176279002639 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 176279002640 DNA binding residues [nucleotide binding] 176279002641 putative dimer interface [polypeptide binding]; other site 176279002642 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 176279002643 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 176279002644 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 176279002645 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 176279002646 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 176279002647 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 176279002648 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 176279002649 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 176279002650 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 176279002651 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176279002652 catalytic residue [active] 176279002653 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 176279002654 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 176279002655 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 176279002656 putative active site [active] 176279002657 catalytic site [active] 176279002658 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 176279002659 putative active site [active] 176279002660 catalytic site [active] 176279002661 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 176279002662 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176279002663 Walker A/P-loop; other site 176279002664 ATP binding site [chemical binding]; other site 176279002665 Q-loop/lid; other site 176279002666 ABC transporter signature motif; other site 176279002667 Walker B; other site 176279002668 D-loop; other site 176279002669 H-loop/switch region; other site 176279002670 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 176279002671 ABC-2 type transporter; Region: ABC2_membrane; cl17235 176279002672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 176279002673 Serpentine type 7TM GPCR chemoreceptor Srx; Region: 7TM_GPCR_Srx; pfam10328 176279002674 Histidine kinase; Region: HisKA_3; pfam07730 176279002675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279002676 ATP binding site [chemical binding]; other site 176279002677 Mg2+ binding site [ion binding]; other site 176279002678 G-X-G motif; other site 176279002679 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 176279002680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279002681 active site 176279002682 phosphorylation site [posttranslational modification] 176279002683 intermolecular recognition site; other site 176279002684 dimerization interface [polypeptide binding]; other site 176279002685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 176279002686 DNA binding residues [nucleotide binding] 176279002687 dimerization interface [polypeptide binding]; other site 176279002688 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 176279002689 Staphylococcal nuclease homologues; Region: SNc; smart00318 176279002690 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 176279002691 Catalytic site; other site 176279002692 aspartate kinase; Reviewed; Region: PRK09034 176279002693 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 176279002694 putative catalytic residues [active] 176279002695 putative nucleotide binding site [chemical binding]; other site 176279002696 putative aspartate binding site [chemical binding]; other site 176279002697 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 176279002698 allosteric regulatory residue; other site 176279002699 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 176279002700 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 176279002701 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 176279002702 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 176279002703 threonine synthase; Reviewed; Region: PRK06721 176279002704 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 176279002705 homodimer interface [polypeptide binding]; other site 176279002706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279002707 catalytic residue [active] 176279002708 homoserine kinase; Provisional; Region: PRK01212 176279002709 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 176279002710 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 176279002711 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 176279002712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279002713 active site 176279002714 motif I; other site 176279002715 motif II; other site 176279002716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279002717 lysine transporter; Provisional; Region: PRK10836 176279002718 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 176279002719 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 176279002720 tetramer interface [polypeptide binding]; other site 176279002721 heme binding pocket [chemical binding]; other site 176279002722 NADPH binding site [chemical binding]; other site 176279002723 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 176279002724 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 176279002725 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 176279002726 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 176279002727 active site 176279002728 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 176279002729 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 176279002730 LexA repressor; Validated; Region: PRK00215 176279002731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176279002732 putative DNA binding site [nucleotide binding]; other site 176279002733 putative Zn2+ binding site [ion binding]; other site 176279002734 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 176279002735 Catalytic site [active] 176279002736 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 176279002737 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 176279002738 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 176279002739 TPP-binding site [chemical binding]; other site 176279002740 dimer interface [polypeptide binding]; other site 176279002741 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 176279002742 PYR/PP interface [polypeptide binding]; other site 176279002743 dimer interface [polypeptide binding]; other site 176279002744 TPP binding site [chemical binding]; other site 176279002745 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 176279002746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 176279002747 Transposase, Mutator family; Region: Transposase_mut; pfam00872 176279002748 MULE transposase domain; Region: MULE; pfam10551 176279002749 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 176279002750 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 176279002751 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 176279002752 active site 176279002753 metal binding site [ion binding]; metal-binding site 176279002754 DNA binding site [nucleotide binding] 176279002755 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 176279002756 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 176279002757 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 176279002758 Walker A/P-loop; other site 176279002759 ATP binding site [chemical binding]; other site 176279002760 Q-loop/lid; other site 176279002761 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 176279002762 ABC transporter signature motif; other site 176279002763 Walker B; other site 176279002764 D-loop; other site 176279002765 H-loop/switch region; other site 176279002766 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 176279002767 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 176279002768 BCCT family transporter; Region: BCCT; pfam02028 176279002769 aconitate hydratase; Validated; Region: PRK09277 176279002770 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 176279002771 substrate binding site [chemical binding]; other site 176279002772 ligand binding site [chemical binding]; other site 176279002773 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 176279002774 substrate binding site [chemical binding]; other site 176279002775 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 176279002776 active site 176279002777 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 176279002778 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 176279002779 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 176279002780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279002781 ATP binding site [chemical binding]; other site 176279002782 Mg2+ binding site [ion binding]; other site 176279002783 G-X-G motif; other site 176279002784 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 176279002785 anchoring element; other site 176279002786 dimer interface [polypeptide binding]; other site 176279002787 ATP binding site [chemical binding]; other site 176279002788 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 176279002789 active site 176279002790 putative metal-binding site [ion binding]; other site 176279002791 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 176279002792 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 176279002793 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 176279002794 CAP-like domain; other site 176279002795 active site 176279002796 primary dimer interface [polypeptide binding]; other site 176279002797 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176279002798 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176279002799 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 176279002800 amino acid carrier protein; Region: agcS; TIGR00835 176279002801 CAT RNA binding domain; Region: CAT_RBD; smart01061 176279002802 transcriptional antiterminator BglG; Provisional; Region: PRK09772 176279002803 PRD domain; Region: PRD; pfam00874 176279002804 PRD domain; Region: PRD; pfam00874 176279002805 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 176279002806 Domain of unknown function DUF20; Region: UPF0118; pfam01594 176279002807 Predicted integral membrane protein [Function unknown]; Region: COG0392 176279002808 Uncharacterized conserved protein [Function unknown]; Region: COG2898 176279002809 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 176279002810 methionine sulfoxide reductase A; Provisional; Region: PRK14054 176279002811 Transcriptional regulator [Transcription]; Region: LytR; COG1316 176279002812 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 176279002813 active site 1 [active] 176279002814 dimer interface [polypeptide binding]; other site 176279002815 hexamer interface [polypeptide binding]; other site 176279002816 active site 2 [active] 176279002817 DNA polymerase IV; Reviewed; Region: PRK03103 176279002818 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 176279002819 active site 176279002820 DNA binding site [nucleotide binding] 176279002821 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 176279002822 prephenate dehydrogenase; Validated; Region: PRK06545 176279002823 prephenate dehydrogenase; Validated; Region: PRK08507 176279002824 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 176279002825 anthranilate synthase component I; Provisional; Region: PRK13567 176279002826 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 176279002827 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 176279002828 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 176279002829 Glutamine amidotransferase class-I; Region: GATase; pfam00117 176279002830 glutamine binding [chemical binding]; other site 176279002831 catalytic triad [active] 176279002832 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 176279002833 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 176279002834 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 176279002835 active site 176279002836 ribulose/triose binding site [chemical binding]; other site 176279002837 phosphate binding site [ion binding]; other site 176279002838 substrate (anthranilate) binding pocket [chemical binding]; other site 176279002839 product (indole) binding pocket [chemical binding]; other site 176279002840 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 176279002841 active site 176279002842 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 176279002843 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 176279002844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279002845 catalytic residue [active] 176279002846 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 176279002847 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 176279002848 substrate binding site [chemical binding]; other site 176279002849 active site 176279002850 catalytic residues [active] 176279002851 heterodimer interface [polypeptide binding]; other site 176279002852 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 176279002853 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 176279002854 potential catalytic triad [active] 176279002855 conserved cys residue [active] 176279002856 FemAB family; Region: FemAB; pfam02388 176279002857 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 176279002858 FemAB family; Region: FemAB; pfam02388 176279002859 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 176279002860 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 176279002861 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 176279002862 intersubunit interface [polypeptide binding]; other site 176279002863 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 176279002864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176279002865 Walker A/P-loop; other site 176279002866 ATP binding site [chemical binding]; other site 176279002867 Q-loop/lid; other site 176279002868 ABC transporter signature motif; other site 176279002869 Walker B; other site 176279002870 D-loop; other site 176279002871 H-loop/switch region; other site 176279002872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 176279002873 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176279002874 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 176279002875 Walker A/P-loop; other site 176279002876 ATP binding site [chemical binding]; other site 176279002877 Q-loop/lid; other site 176279002878 ABC transporter signature motif; other site 176279002879 Walker B; other site 176279002880 D-loop; other site 176279002881 H-loop/switch region; other site 176279002882 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 176279002883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279002884 dimer interface [polypeptide binding]; other site 176279002885 conserved gate region; other site 176279002886 putative PBP binding loops; other site 176279002887 ABC-ATPase subunit interface; other site 176279002888 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 176279002889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279002890 dimer interface [polypeptide binding]; other site 176279002891 conserved gate region; other site 176279002892 putative PBP binding loops; other site 176279002893 ABC-ATPase subunit interface; other site 176279002894 oligoendopeptidase F; Region: pepF; TIGR00181 176279002895 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 176279002896 active site 176279002897 Zn binding site [ion binding]; other site 176279002898 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 176279002899 PhoU domain; Region: PhoU; pfam01895 176279002900 PhoU domain; Region: PhoU; pfam01895 176279002901 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 176279002902 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 176279002903 Walker A/P-loop; other site 176279002904 ATP binding site [chemical binding]; other site 176279002905 Q-loop/lid; other site 176279002906 ABC transporter signature motif; other site 176279002907 Walker B; other site 176279002908 D-loop; other site 176279002909 H-loop/switch region; other site 176279002910 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 176279002911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279002912 dimer interface [polypeptide binding]; other site 176279002913 conserved gate region; other site 176279002914 putative PBP binding loops; other site 176279002915 ABC-ATPase subunit interface; other site 176279002916 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 176279002917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279002918 dimer interface [polypeptide binding]; other site 176279002919 conserved gate region; other site 176279002920 ABC-ATPase subunit interface; other site 176279002921 PBP superfamily domain; Region: PBP_like_2; cl17296 176279002922 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 176279002923 S1 domain; Region: S1_2; pfam13509 176279002924 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 176279002925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279002926 Walker A/P-loop; other site 176279002927 ATP binding site [chemical binding]; other site 176279002928 Q-loop/lid; other site 176279002929 ABC transporter signature motif; other site 176279002930 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176279002931 Walker B; other site 176279002932 D-loop; other site 176279002933 H-loop/switch region; other site 176279002934 ABC transporter; Region: ABC_tran_2; pfam12848 176279002935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176279002936 aspartate kinase; Reviewed; Region: PRK06635 176279002937 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 176279002938 putative nucleotide binding site [chemical binding]; other site 176279002939 putative catalytic residues [active] 176279002940 putative Mg ion binding site [ion binding]; other site 176279002941 putative aspartate binding site [chemical binding]; other site 176279002942 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 176279002943 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 176279002944 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 176279002945 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 176279002946 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 176279002947 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 176279002948 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 176279002949 dimer interface [polypeptide binding]; other site 176279002950 active site 176279002951 catalytic residue [active] 176279002952 dihydrodipicolinate reductase; Provisional; Region: PRK00048 176279002953 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 176279002954 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 176279002955 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 176279002956 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 176279002957 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 176279002958 active site 176279002959 trimer interface [polypeptide binding]; other site 176279002960 substrate binding site [chemical binding]; other site 176279002961 CoA binding site [chemical binding]; other site 176279002962 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176279002963 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 176279002964 metal binding site [ion binding]; metal-binding site 176279002965 dimer interface [polypeptide binding]; other site 176279002966 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 176279002967 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 176279002968 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176279002969 catalytic residue [active] 176279002970 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 176279002971 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 176279002972 active site 176279002973 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176279002974 substrate binding site [chemical binding]; other site 176279002975 catalytic residues [active] 176279002976 dimer interface [polypeptide binding]; other site 176279002977 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 176279002978 DNA-binding site [nucleotide binding]; DNA binding site 176279002979 RNA-binding motif; other site 176279002980 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 176279002981 acylphosphatase; Provisional; Region: PRK14431 176279002982 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 176279002983 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 176279002984 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 176279002985 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 176279002986 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 176279002987 metal ion-dependent adhesion site (MIDAS); other site 176279002988 MoxR-like ATPases [General function prediction only]; Region: COG0714 176279002989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279002990 Walker A motif; other site 176279002991 ATP binding site [chemical binding]; other site 176279002992 Walker B motif; other site 176279002993 arginine finger; other site 176279002994 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 176279002995 active site 176279002996 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 176279002997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279002998 Walker A/P-loop; other site 176279002999 ATP binding site [chemical binding]; other site 176279003000 Q-loop/lid; other site 176279003001 ABC transporter signature motif; other site 176279003002 Walker B; other site 176279003003 D-loop; other site 176279003004 H-loop/switch region; other site 176279003005 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 176279003006 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 176279003007 E3 interaction surface; other site 176279003008 lipoyl attachment site [posttranslational modification]; other site 176279003009 e3 binding domain; Region: E3_binding; pfam02817 176279003010 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 176279003011 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 176279003012 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 176279003013 TPP-binding site [chemical binding]; other site 176279003014 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 176279003015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176279003016 HAMP domain; Region: HAMP; pfam00672 176279003017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176279003018 dimer interface [polypeptide binding]; other site 176279003019 phosphorylation site [posttranslational modification] 176279003020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279003021 ATP binding site [chemical binding]; other site 176279003022 Mg2+ binding site [ion binding]; other site 176279003023 G-X-G motif; other site 176279003024 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176279003025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279003026 active site 176279003027 phosphorylation site [posttranslational modification] 176279003028 intermolecular recognition site; other site 176279003029 dimerization interface [polypeptide binding]; other site 176279003030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176279003031 DNA binding site [nucleotide binding] 176279003032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279003033 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279003034 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 176279003035 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 176279003036 active site 176279003037 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 176279003038 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 176279003039 active site 176279003040 homodimer interface [polypeptide binding]; other site 176279003041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 176279003042 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 176279003043 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 176279003044 C-terminal peptidase (prc); Region: prc; TIGR00225 176279003045 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 176279003046 protein binding site [polypeptide binding]; other site 176279003047 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 176279003048 Catalytic dyad [active] 176279003049 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 176279003050 hypothetical protein; Provisional; Region: PRK13672 176279003051 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 176279003052 HPr interaction site; other site 176279003053 glycerol kinase (GK) interaction site [polypeptide binding]; other site 176279003054 active site 176279003055 phosphorylation site [posttranslational modification] 176279003056 methionine sulfoxide reductase B; Provisional; Region: PRK00222 176279003057 SelR domain; Region: SelR; pfam01641 176279003058 methionine sulfoxide reductase A; Provisional; Region: PRK13014 176279003059 EDD domain protein, DegV family; Region: DegV; TIGR00762 176279003060 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 176279003061 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 176279003062 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 176279003063 folate binding site [chemical binding]; other site 176279003064 NADP+ binding site [chemical binding]; other site 176279003065 thymidylate synthase; Region: thym_sym; TIGR03284 176279003066 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 176279003067 dimerization interface [polypeptide binding]; other site 176279003068 active site 176279003069 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176279003070 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176279003071 Walker A/P-loop; other site 176279003072 ATP binding site [chemical binding]; other site 176279003073 Q-loop/lid; other site 176279003074 ABC transporter signature motif; other site 176279003075 Walker B; other site 176279003076 D-loop; other site 176279003077 H-loop/switch region; other site 176279003078 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 176279003079 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 176279003080 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 176279003081 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 176279003082 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 176279003083 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 176279003084 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 176279003085 RNA/DNA hybrid binding site [nucleotide binding]; other site 176279003086 active site 176279003087 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176279003088 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 176279003089 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 176279003090 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 176279003091 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 176279003092 GA module; Region: GA; smart00844 176279003093 GA module; Region: GA; smart00844 176279003094 GA module; Region: GA; smart00844 176279003095 GA module; Region: GA; smart00844 176279003096 GA module; Region: GA; smart00844 176279003097 GA module; Region: GA; smart00844 176279003098 GA module; Region: GA; pfam01468 176279003099 GA module; Region: GA; smart00844 176279003100 GA module; Region: GA; smart00844 176279003101 GA module; Region: GA; smart00844 176279003102 GA module; Region: GA; pfam01468 176279003103 GA module; Region: GA; smart00844 176279003104 GA module; Region: GA; smart00844 176279003105 GA module; Region: GA; smart00844 176279003106 GA module; Region: GA; smart00844 176279003107 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 176279003108 GA module; Region: GA; smart00844 176279003109 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 176279003110 GA module; Region: GA; smart00844 176279003111 GA module; Region: GA; smart00844 176279003112 GA module; Region: GA; smart00844 176279003113 GA module; Region: GA; smart00844 176279003114 GA module; Region: GA; smart00844 176279003115 GA module; Region: GA; smart00844 176279003116 GA module; Region: GA; pfam01468 176279003117 GA module; Region: GA; smart00844 176279003118 GA module; Region: GA; smart00844 176279003119 GA module; Region: GA; smart00844 176279003120 GA module; Region: GA; smart00844 176279003121 GA module; Region: GA; smart00844 176279003122 GA module; Region: GA; pfam01468 176279003123 GA module; Region: GA; smart00844 176279003124 GA module; Region: GA; smart00844 176279003125 GA module; Region: GA; pfam01468 176279003126 GA module; Region: GA; smart00844 176279003127 GA module; Region: GA; smart00844 176279003128 GA module; Region: GA; smart00844 176279003129 GA module; Region: GA; smart00844 176279003130 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279003131 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279003132 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279003133 5'-3' exonuclease; Region: 53EXOc; smart00475 176279003134 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 176279003135 active site 176279003136 metal binding site 1 [ion binding]; metal-binding site 176279003137 putative 5' ssDNA interaction site; other site 176279003138 metal binding site 3; metal-binding site 176279003139 metal binding site 2 [ion binding]; metal-binding site 176279003140 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 176279003141 putative DNA binding site [nucleotide binding]; other site 176279003142 putative metal binding site [ion binding]; other site 176279003143 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 176279003144 Dynamin family; Region: Dynamin_N; pfam00350 176279003145 G1 box; other site 176279003146 GTP/Mg2+ binding site [chemical binding]; other site 176279003147 G2 box; other site 176279003148 Switch I region; other site 176279003149 G3 box; other site 176279003150 Switch II region; other site 176279003151 G4 box; other site 176279003152 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 176279003153 Dynamin family; Region: Dynamin_N; pfam00350 176279003154 G1 box; other site 176279003155 GTP/Mg2+ binding site [chemical binding]; other site 176279003156 G2 box; other site 176279003157 Switch I region; other site 176279003158 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 176279003159 G3 box; other site 176279003160 Switch II region; other site 176279003161 GTP/Mg2+ binding site [chemical binding]; other site 176279003162 G4 box; other site 176279003163 G5 box; other site 176279003164 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 176279003165 NADH(P)-binding; Region: NAD_binding_10; pfam13460 176279003166 putative NAD(P) binding site [chemical binding]; other site 176279003167 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 176279003168 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 176279003169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279003170 cell division protein GpsB; Provisional; Region: PRK14127 176279003171 DivIVA domain; Region: DivI1A_domain; TIGR03544 176279003172 hypothetical protein; Provisional; Region: PRK13660 176279003173 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 176279003174 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 176279003175 Transglycosylase; Region: Transgly; pfam00912 176279003176 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 176279003177 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 176279003178 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 176279003179 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 176279003180 minor groove reading motif; other site 176279003181 helix-hairpin-helix signature motif; other site 176279003182 substrate binding pocket [chemical binding]; other site 176279003183 active site 176279003184 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 176279003185 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 176279003186 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 176279003187 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 176279003188 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 176279003189 putative dimer interface [polypeptide binding]; other site 176279003190 putative anticodon binding site; other site 176279003191 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 176279003192 homodimer interface [polypeptide binding]; other site 176279003193 motif 1; other site 176279003194 motif 2; other site 176279003195 active site 176279003196 motif 3; other site 176279003197 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 176279003198 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 176279003199 active site 176279003200 catalytic site [active] 176279003201 substrate binding site [chemical binding]; other site 176279003202 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 176279003203 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 176279003204 Biotin operon repressor [Transcription]; Region: BirA; COG1654 176279003205 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 176279003206 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 176279003207 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 176279003208 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 176279003209 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 176279003210 active site 176279003211 NTP binding site [chemical binding]; other site 176279003212 metal binding triad [ion binding]; metal-binding site 176279003213 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 176279003214 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 176279003215 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 176279003216 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 176279003217 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 176279003218 homodimer interface [polypeptide binding]; other site 176279003219 metal binding site [ion binding]; metal-binding site 176279003220 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 176279003221 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 176279003222 Uncharacterized conserved protein [Function unknown]; Region: COG5582 176279003223 UPF0302 domain; Region: UPF0302; pfam08864 176279003224 A short protein domain of unknown function; Region: IDEAL; smart00914 176279003225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176279003226 binding surface 176279003227 TPR motif; other site 176279003228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176279003229 TPR motif; other site 176279003230 binding surface 176279003231 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 176279003232 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 176279003233 hinge; other site 176279003234 active site 176279003235 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 176279003236 active site 176279003237 dimer interface [polypeptide binding]; other site 176279003238 metal binding site [ion binding]; metal-binding site 176279003239 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 176279003240 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 176279003241 Tetramer interface [polypeptide binding]; other site 176279003242 active site 176279003243 FMN-binding site [chemical binding]; other site 176279003244 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 176279003245 active site 176279003246 multimer interface [polypeptide binding]; other site 176279003247 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 176279003248 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 176279003249 substrate binding pocket [chemical binding]; other site 176279003250 chain length determination region; other site 176279003251 substrate-Mg2+ binding site; other site 176279003252 catalytic residues [active] 176279003253 aspartate-rich region 1; other site 176279003254 active site lid residues [active] 176279003255 aspartate-rich region 2; other site 176279003256 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 176279003257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279003258 S-adenosylmethionine binding site [chemical binding]; other site 176279003259 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 176279003260 IHF dimer interface [polypeptide binding]; other site 176279003261 IHF - DNA interface [nucleotide binding]; other site 176279003262 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 176279003263 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 176279003264 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 176279003265 GTP-binding protein Der; Reviewed; Region: PRK00093 176279003266 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 176279003267 G1 box; other site 176279003268 GTP/Mg2+ binding site [chemical binding]; other site 176279003269 Switch I region; other site 176279003270 G2 box; other site 176279003271 Switch II region; other site 176279003272 G3 box; other site 176279003273 G4 box; other site 176279003274 G5 box; other site 176279003275 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 176279003276 G1 box; other site 176279003277 GTP/Mg2+ binding site [chemical binding]; other site 176279003278 Switch I region; other site 176279003279 G2 box; other site 176279003280 G3 box; other site 176279003281 Switch II region; other site 176279003282 G4 box; other site 176279003283 G5 box; other site 176279003284 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 176279003285 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 176279003286 RNA binding site [nucleotide binding]; other site 176279003287 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 176279003288 RNA binding site [nucleotide binding]; other site 176279003289 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 176279003290 RNA binding site [nucleotide binding]; other site 176279003291 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 176279003292 RNA binding site [nucleotide binding]; other site 176279003293 cytidylate kinase; Provisional; Region: cmk; PRK00023 176279003294 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 176279003295 CMP-binding site; other site 176279003296 The sites determining sugar specificity; other site 176279003297 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 176279003298 active site 176279003299 homotetramer interface [polypeptide binding]; other site 176279003300 homodimer interface [polypeptide binding]; other site 176279003301 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 176279003302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 176279003303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279003304 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 176279003305 DEAD-like helicases superfamily; Region: DEXDc; smart00487 176279003306 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176279003307 ATP binding site [chemical binding]; other site 176279003308 putative Mg++ binding site [ion binding]; other site 176279003309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279003310 nucleotide binding region [chemical binding]; other site 176279003311 ATP-binding site [chemical binding]; other site 176279003312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 176279003313 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 176279003314 Predicted membrane protein [Function unknown]; Region: COG3601 176279003315 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 176279003316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 176279003317 dimerization interface [polypeptide binding]; other site 176279003318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176279003319 dimer interface [polypeptide binding]; other site 176279003320 phosphorylation site [posttranslational modification] 176279003321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279003322 ATP binding site [chemical binding]; other site 176279003323 Mg2+ binding site [ion binding]; other site 176279003324 G-X-G motif; other site 176279003325 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176279003326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279003327 active site 176279003328 phosphorylation site [posttranslational modification] 176279003329 intermolecular recognition site; other site 176279003330 dimerization interface [polypeptide binding]; other site 176279003331 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176279003332 DNA binding site [nucleotide binding] 176279003333 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 176279003334 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176279003335 RNA binding surface [nucleotide binding]; other site 176279003336 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 176279003337 active site 176279003338 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 176279003339 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 176279003340 Domain of unknown function (DUF309); Region: DUF309; pfam03745 176279003341 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 176279003342 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 176279003343 active site 176279003344 Int/Topo IB signature motif; other site 176279003345 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 176279003346 metal binding site 2 [ion binding]; metal-binding site 176279003347 putative DNA binding helix; other site 176279003348 metal binding site 1 [ion binding]; metal-binding site 176279003349 dimer interface [polypeptide binding]; other site 176279003350 structural Zn2+ binding site [ion binding]; other site 176279003351 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 176279003352 dimer interface [polypeptide binding]; other site 176279003353 ADP-ribose binding site [chemical binding]; other site 176279003354 active site 176279003355 nudix motif; other site 176279003356 metal binding site [ion binding]; metal-binding site 176279003357 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 176279003358 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 176279003359 active site 176279003360 catalytic tetrad [active] 176279003361 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 176279003362 classical (c) SDRs; Region: SDR_c; cd05233 176279003363 NAD(P) binding site [chemical binding]; other site 176279003364 active site 176279003365 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 176279003366 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 176279003367 ribonuclease Z; Region: RNase_Z; TIGR02651 176279003368 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 176279003369 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 176279003370 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 176279003371 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176279003372 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 176279003373 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 176279003374 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 176279003375 Ca binding site [ion binding]; other site 176279003376 active site 176279003377 catalytic site [active] 176279003378 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 176279003379 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 176279003380 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 176279003381 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 176279003382 peptidase T-like protein; Region: PepT-like; TIGR01883 176279003383 metal binding site [ion binding]; metal-binding site 176279003384 putative dimer interface [polypeptide binding]; other site 176279003385 Predicted membrane protein [Function unknown]; Region: COG4129 176279003386 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 176279003387 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 176279003388 Disulphide isomerase; Region: Disulph_isomer; pfam06491 176279003389 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 176279003390 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 176279003391 E3 interaction surface; other site 176279003392 lipoyl attachment site [posttranslational modification]; other site 176279003393 e3 binding domain; Region: E3_binding; pfam02817 176279003394 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 176279003395 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 176279003396 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 176279003397 alpha subunit interface [polypeptide binding]; other site 176279003398 TPP binding site [chemical binding]; other site 176279003399 heterodimer interface [polypeptide binding]; other site 176279003400 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 176279003401 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 176279003402 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 176279003403 tetramer interface [polypeptide binding]; other site 176279003404 TPP-binding site [chemical binding]; other site 176279003405 heterodimer interface [polypeptide binding]; other site 176279003406 phosphorylation loop region [posttranslational modification] 176279003407 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 176279003408 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 176279003409 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279003410 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176279003411 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 176279003412 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 176279003413 Walker A/P-loop; other site 176279003414 ATP binding site [chemical binding]; other site 176279003415 Q-loop/lid; other site 176279003416 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 176279003417 Q-loop/lid; other site 176279003418 ABC transporter signature motif; other site 176279003419 Walker B; other site 176279003420 D-loop; other site 176279003421 H-loop/switch region; other site 176279003422 arginine repressor; Provisional; Region: PRK04280 176279003423 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 176279003424 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 176279003425 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 176279003426 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 176279003427 substrate binding pocket [chemical binding]; other site 176279003428 chain length determination region; other site 176279003429 substrate-Mg2+ binding site; other site 176279003430 catalytic residues [active] 176279003431 aspartate-rich region 1; other site 176279003432 active site lid residues [active] 176279003433 aspartate-rich region 2; other site 176279003434 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 176279003435 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 176279003436 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 176279003437 generic binding surface II; other site 176279003438 generic binding surface I; other site 176279003439 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 176279003440 putative RNA binding site [nucleotide binding]; other site 176279003441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 176279003442 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 176279003443 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176279003444 ATP-grasp domain; Region: ATP-grasp_4; cl17255 176279003445 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 176279003446 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 176279003447 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 176279003448 carboxyltransferase (CT) interaction site; other site 176279003449 biotinylation site [posttranslational modification]; other site 176279003450 acetylornithine aminotransferase; Provisional; Region: PRK04260 176279003451 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176279003452 inhibitor-cofactor binding pocket; inhibition site 176279003453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279003454 catalytic residue [active] 176279003455 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 176279003456 nucleotide binding site [chemical binding]; other site 176279003457 N-acetyl-L-glutamate binding site [chemical binding]; other site 176279003458 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 176279003459 heterotetramer interface [polypeptide binding]; other site 176279003460 active site pocket [active] 176279003461 cleavage site 176279003462 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 176279003463 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 176279003464 elongation factor P; Validated; Region: PRK00529 176279003465 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 176279003466 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 176279003467 RNA binding site [nucleotide binding]; other site 176279003468 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 176279003469 RNA binding site [nucleotide binding]; other site 176279003470 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 176279003471 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 176279003472 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 176279003473 active site 176279003474 Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211 176279003475 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 176279003476 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176279003477 active site residue [active] 176279003478 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 176279003479 tetramer interface [polypeptide binding]; other site 176279003480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279003481 catalytic residue [active] 176279003482 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 176279003483 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 176279003484 tetramer interface [polypeptide binding]; other site 176279003485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279003486 catalytic residue [active] 176279003487 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 176279003488 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 176279003489 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 176279003490 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 176279003491 ADP binding site [chemical binding]; other site 176279003492 magnesium binding site [ion binding]; other site 176279003493 putative shikimate binding site; other site 176279003494 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 176279003495 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 176279003496 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 176279003497 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 176279003498 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 176279003499 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 176279003500 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 176279003501 Type II/IV secretion system protein; Region: T2SE; pfam00437 176279003502 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 176279003503 Walker A motif; other site 176279003504 ATP binding site [chemical binding]; other site 176279003505 Walker B motif; other site 176279003506 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 176279003507 Uncharacterized conserved protein [Function unknown]; Region: COG0011 176279003508 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 176279003509 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 176279003510 nucleotide binding site [chemical binding]; other site 176279003511 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 176279003512 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 176279003513 Rhomboid family; Region: Rhomboid; pfam01694 176279003514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176279003515 binding surface 176279003516 TPR motif; other site 176279003517 TPR repeat; Region: TPR_11; pfam13414 176279003518 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 176279003519 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 176279003520 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 176279003521 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 176279003522 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 176279003523 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 176279003524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 176279003525 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 176279003526 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 176279003527 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 176279003528 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 176279003529 metal binding site 2 [ion binding]; metal-binding site 176279003530 putative DNA binding helix; other site 176279003531 metal binding site 1 [ion binding]; metal-binding site 176279003532 dimer interface [polypeptide binding]; other site 176279003533 structural Zn2+ binding site [ion binding]; other site 176279003534 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 176279003535 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176279003536 ABC-ATPase subunit interface; other site 176279003537 dimer interface [polypeptide binding]; other site 176279003538 putative PBP binding regions; other site 176279003539 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 176279003540 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 176279003541 endonuclease IV; Provisional; Region: PRK01060 176279003542 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 176279003543 AP (apurinic/apyrimidinic) site pocket; other site 176279003544 DNA interaction; other site 176279003545 Metal-binding active site; metal-binding site 176279003546 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 176279003547 DEAD-like helicases superfamily; Region: DEXDc; smart00487 176279003548 ATP binding site [chemical binding]; other site 176279003549 Mg++ binding site [ion binding]; other site 176279003550 motif III; other site 176279003551 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279003552 nucleotide binding region [chemical binding]; other site 176279003553 ATP-binding site [chemical binding]; other site 176279003554 Uncharacterized conserved protein [Function unknown]; Region: COG0327 176279003555 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 176279003556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 176279003557 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 176279003558 Uncharacterized conserved protein [Function unknown]; Region: COG0327 176279003559 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 176279003560 Family of unknown function (DUF633); Region: DUF633; pfam04816 176279003561 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 176279003562 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 176279003563 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 176279003564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 176279003565 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 176279003566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 176279003567 DNA binding residues [nucleotide binding] 176279003568 DNA primase, catalytic core; Region: dnaG; TIGR01391 176279003569 CHC2 zinc finger; Region: zf-CHC2; pfam01807 176279003570 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 176279003571 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 176279003572 active site 176279003573 metal binding site [ion binding]; metal-binding site 176279003574 interdomain interaction site; other site 176279003575 PEP synthetase regulatory protein; Provisional; Region: PRK05339 176279003576 HTH domain; Region: HTH_11; pfam08279 176279003577 FOG: CBS domain [General function prediction only]; Region: COG0517 176279003578 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 176279003579 glycyl-tRNA synthetase; Provisional; Region: PRK04173 176279003580 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 176279003581 motif 1; other site 176279003582 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 176279003583 active site 176279003584 motif 2; other site 176279003585 motif 3; other site 176279003586 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 176279003587 anticodon binding site; other site 176279003588 DNA repair protein RecO; Region: reco; TIGR00613 176279003589 Recombination protein O N terminal; Region: RecO_N; pfam11967 176279003590 Recombination protein O C terminal; Region: RecO_C; pfam02565 176279003591 GTPase Era; Reviewed; Region: era; PRK00089 176279003592 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 176279003593 G1 box; other site 176279003594 GTP/Mg2+ binding site [chemical binding]; other site 176279003595 Switch I region; other site 176279003596 G2 box; other site 176279003597 Switch II region; other site 176279003598 G3 box; other site 176279003599 G4 box; other site 176279003600 G5 box; other site 176279003601 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 176279003602 active site 176279003603 catalytic motif [active] 176279003604 Zn binding site [ion binding]; other site 176279003605 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 176279003606 metal-binding heat shock protein; Provisional; Region: PRK00016 176279003607 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 176279003608 PhoH-like protein; Region: PhoH; pfam02562 176279003609 hypothetical protein; Provisional; Region: PRK13665 176279003610 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 176279003611 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 176279003612 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 176279003613 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 176279003614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279003615 FeS/SAM binding site; other site 176279003616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 176279003617 RNA methyltransferase, RsmE family; Region: TIGR00046 176279003618 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 176279003619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279003620 S-adenosylmethionine binding site [chemical binding]; other site 176279003621 chaperone protein DnaJ; Provisional; Region: PRK14280 176279003622 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 176279003623 HSP70 interaction site [polypeptide binding]; other site 176279003624 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 176279003625 substrate binding site [polypeptide binding]; other site 176279003626 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 176279003627 Zn binding sites [ion binding]; other site 176279003628 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 176279003629 dimer interface [polypeptide binding]; other site 176279003630 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 176279003631 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 176279003632 nucleotide binding site [chemical binding]; other site 176279003633 NEF interaction site [polypeptide binding]; other site 176279003634 SBD interface [polypeptide binding]; other site 176279003635 heat shock protein GrpE; Provisional; Region: PRK14140 176279003636 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 176279003637 dimer interface [polypeptide binding]; other site 176279003638 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 176279003639 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 176279003640 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 176279003641 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 176279003642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279003643 FeS/SAM binding site; other site 176279003644 HemN C-terminal domain; Region: HemN_C; pfam06969 176279003645 GTP-binding protein LepA; Provisional; Region: PRK05433 176279003646 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 176279003647 G1 box; other site 176279003648 putative GEF interaction site [polypeptide binding]; other site 176279003649 GTP/Mg2+ binding site [chemical binding]; other site 176279003650 Switch I region; other site 176279003651 G2 box; other site 176279003652 G3 box; other site 176279003653 Switch II region; other site 176279003654 G4 box; other site 176279003655 G5 box; other site 176279003656 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 176279003657 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 176279003658 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 176279003659 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 176279003660 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 176279003661 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 176279003662 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 176279003663 Competence protein; Region: Competence; pfam03772 176279003664 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 176279003665 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 176279003666 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 176279003667 catalytic motif [active] 176279003668 Zn binding site [ion binding]; other site 176279003669 SLBB domain; Region: SLBB; pfam10531 176279003670 comEA protein; Region: comE; TIGR01259 176279003671 Helix-hairpin-helix motif; Region: HHH; pfam00633 176279003672 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 176279003673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279003674 S-adenosylmethionine binding site [chemical binding]; other site 176279003675 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 176279003676 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176279003677 Zn2+ binding site [ion binding]; other site 176279003678 Mg2+ binding site [ion binding]; other site 176279003679 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 176279003680 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 176279003681 active site 176279003682 (T/H)XGH motif; other site 176279003683 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 176279003684 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 176279003685 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 176279003686 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 176279003687 shikimate binding site; other site 176279003688 NAD(P) binding site [chemical binding]; other site 176279003689 GTPase YqeH; Provisional; Region: PRK13796 176279003690 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 176279003691 GTP/Mg2+ binding site [chemical binding]; other site 176279003692 G4 box; other site 176279003693 G5 box; other site 176279003694 G1 box; other site 176279003695 Switch I region; other site 176279003696 G2 box; other site 176279003697 G3 box; other site 176279003698 Switch II region; other site 176279003699 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 176279003700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279003701 active site 176279003702 motif I; other site 176279003703 motif II; other site 176279003704 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 176279003705 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 176279003706 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 176279003707 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 176279003708 putative active site [active] 176279003709 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 176279003710 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 176279003711 ATP-grasp domain; Region: ATP-grasp_4; cl17255 176279003712 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 176279003713 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 176279003714 carboxyltransferase (CT) interaction site; other site 176279003715 biotinylation site [posttranslational modification]; other site 176279003716 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 176279003717 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 176279003718 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 176279003719 Transposase IS200 like; Region: Y1_Tnp; pfam01797 176279003720 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 176279003721 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 176279003722 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 176279003723 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 176279003724 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 176279003725 Sugar specificity; other site 176279003726 Pyrimidine base specificity; other site 176279003727 ATP-binding site [chemical binding]; other site 176279003728 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 176279003729 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 176279003730 Peptidase family U32; Region: Peptidase_U32; pfam01136 176279003731 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 176279003732 Peptidase family U32; Region: Peptidase_U32; pfam01136 176279003733 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 176279003734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279003735 S-adenosylmethionine binding site [chemical binding]; other site 176279003736 hypothetical protein; Provisional; Region: PRK13678 176279003737 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 176279003738 hypothetical protein; Provisional; Region: PRK05473 176279003739 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 176279003740 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 176279003741 motif 1; other site 176279003742 active site 176279003743 motif 2; other site 176279003744 motif 3; other site 176279003745 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 176279003746 DHHA1 domain; Region: DHHA1; pfam02272 176279003747 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 176279003748 AAA domain; Region: AAA_30; pfam13604 176279003749 Family description; Region: UvrD_C_2; pfam13538 176279003750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176279003751 binding surface 176279003752 TPR repeat; Region: TPR_11; pfam13414 176279003753 TPR motif; other site 176279003754 Tetratricopeptide repeat; Region: TPR_12; pfam13424 176279003755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 176279003756 binding surface 176279003757 TPR motif; other site 176279003758 TPR repeat; Region: TPR_11; pfam13414 176279003759 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 176279003760 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 176279003761 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 176279003762 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 176279003763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176279003764 catalytic residue [active] 176279003765 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 176279003766 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 176279003767 Predicted transcriptional regulator [Transcription]; Region: COG1959 176279003768 Transcriptional regulator; Region: Rrf2; pfam02082 176279003769 recombination factor protein RarA; Reviewed; Region: PRK13342 176279003770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279003771 Walker A motif; other site 176279003772 ATP binding site [chemical binding]; other site 176279003773 Walker B motif; other site 176279003774 arginine finger; other site 176279003775 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 176279003776 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 176279003777 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 176279003778 putative ATP binding site [chemical binding]; other site 176279003779 putative substrate interface [chemical binding]; other site 176279003780 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 176279003781 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 176279003782 dimer interface [polypeptide binding]; other site 176279003783 anticodon binding site; other site 176279003784 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 176279003785 homodimer interface [polypeptide binding]; other site 176279003786 motif 1; other site 176279003787 active site 176279003788 motif 2; other site 176279003789 GAD domain; Region: GAD; pfam02938 176279003790 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 176279003791 motif 3; other site 176279003792 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 176279003793 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 176279003794 dimer interface [polypeptide binding]; other site 176279003795 motif 1; other site 176279003796 active site 176279003797 motif 2; other site 176279003798 motif 3; other site 176279003799 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 176279003800 anticodon binding site; other site 176279003801 Bacterial SH3 domain homologues; Region: SH3b; smart00287 176279003802 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 176279003803 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 176279003804 active site 176279003805 metal binding site [ion binding]; metal-binding site 176279003806 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 176279003807 putative active site [active] 176279003808 dimerization interface [polypeptide binding]; other site 176279003809 putative tRNAtyr binding site [nucleotide binding]; other site 176279003810 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 176279003811 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176279003812 Zn2+ binding site [ion binding]; other site 176279003813 Mg2+ binding site [ion binding]; other site 176279003814 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 176279003815 synthetase active site [active] 176279003816 NTP binding site [chemical binding]; other site 176279003817 metal binding site [ion binding]; metal-binding site 176279003818 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 176279003819 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 176279003820 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176279003821 active site 176279003822 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 176279003823 DHH family; Region: DHH; pfam01368 176279003824 DHHA1 domain; Region: DHHA1; pfam02272 176279003825 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 176279003826 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 176279003827 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 176279003828 Protein export membrane protein; Region: SecD_SecF; cl14618 176279003829 Protein export membrane protein; Region: SecD_SecF; pfam02355 176279003830 Preprotein translocase subunit; Region: YajC; pfam02699 176279003831 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 176279003832 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 176279003833 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 176279003834 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 176279003835 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 176279003836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279003837 Walker A motif; other site 176279003838 ATP binding site [chemical binding]; other site 176279003839 Walker B motif; other site 176279003840 arginine finger; other site 176279003841 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 176279003842 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 176279003843 RuvA N terminal domain; Region: RuvA_N; pfam01330 176279003844 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 176279003845 hypothetical protein; Provisional; Region: PRK04435 176279003846 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 176279003847 GTPase CgtA; Reviewed; Region: obgE; PRK12297 176279003848 GTP1/OBG; Region: GTP1_OBG; pfam01018 176279003849 Obg GTPase; Region: Obg; cd01898 176279003850 G1 box; other site 176279003851 GTP/Mg2+ binding site [chemical binding]; other site 176279003852 Switch I region; other site 176279003853 G2 box; other site 176279003854 G3 box; other site 176279003855 Switch II region; other site 176279003856 G4 box; other site 176279003857 G5 box; other site 176279003858 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 176279003859 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 176279003860 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 176279003861 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 176279003862 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 176279003863 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 176279003864 rod shape-determining protein MreC; Provisional; Region: PRK13922 176279003865 rod shape-determining protein MreC; Region: MreC; pfam04085 176279003866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279003867 S-adenosylmethionine binding site [chemical binding]; other site 176279003868 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 176279003869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279003870 S-adenosylmethionine binding site [chemical binding]; other site 176279003871 aminoglycoside resistance protein; Provisional; Region: PRK13746 176279003872 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 176279003873 active site 176279003874 NTP binding site [chemical binding]; other site 176279003875 metal binding triad [ion binding]; metal-binding site 176279003876 antibiotic binding site [chemical binding]; other site 176279003877 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 176279003878 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 176279003879 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 176279003880 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 176279003881 Int/Topo IB signature motif; other site 176279003882 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 176279003883 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 176279003884 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 176279003885 Int/Topo IB signature motif; other site 176279003886 hypothetical protein; Reviewed; Region: PRK00024 176279003887 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 176279003888 MPN+ (JAMM) motif; other site 176279003889 Zinc-binding site [ion binding]; other site 176279003890 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 176279003891 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 176279003892 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 176279003893 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176279003894 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176279003895 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 176279003896 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 176279003897 active site 176279003898 HIGH motif; other site 176279003899 nucleotide binding site [chemical binding]; other site 176279003900 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 176279003901 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 176279003902 active site 176279003903 KMSKS motif; other site 176279003904 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 176279003905 tRNA binding surface [nucleotide binding]; other site 176279003906 anticodon binding site; other site 176279003907 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 176279003908 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 176279003909 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 176279003910 Putative ammonia monooxygenase; Region: AmoA; pfam05145 176279003911 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 176279003912 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 176279003913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176279003914 inhibitor-cofactor binding pocket; inhibition site 176279003915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279003916 catalytic residue [active] 176279003917 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 176279003918 dimer interface [polypeptide binding]; other site 176279003919 active site 176279003920 Schiff base residues; other site 176279003921 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 176279003922 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 176279003923 active site 176279003924 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 176279003925 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 176279003926 domain interfaces; other site 176279003927 active site 176279003928 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 176279003929 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 176279003930 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 176279003931 tRNA; other site 176279003932 putative tRNA binding site [nucleotide binding]; other site 176279003933 putative NADP binding site [chemical binding]; other site 176279003934 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 176279003935 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 176279003936 G1 box; other site 176279003937 GTP/Mg2+ binding site [chemical binding]; other site 176279003938 Switch I region; other site 176279003939 G2 box; other site 176279003940 G3 box; other site 176279003941 Switch II region; other site 176279003942 G4 box; other site 176279003943 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 176279003944 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 176279003945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279003946 Walker A motif; other site 176279003947 ATP binding site [chemical binding]; other site 176279003948 Walker B motif; other site 176279003949 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 176279003950 trigger factor; Provisional; Region: tig; PRK01490 176279003951 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 176279003952 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 176279003953 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 176279003954 active site 176279003955 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 176279003956 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 176279003957 23S rRNA binding site [nucleotide binding]; other site 176279003958 L21 binding site [polypeptide binding]; other site 176279003959 L13 binding site [polypeptide binding]; other site 176279003960 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 176279003961 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 176279003962 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 176279003963 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 176279003964 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 176279003965 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 176279003966 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 176279003967 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 176279003968 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 176279003969 active site 176279003970 dimer interface [polypeptide binding]; other site 176279003971 motif 1; other site 176279003972 motif 2; other site 176279003973 motif 3; other site 176279003974 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 176279003975 anticodon binding site; other site 176279003976 primosomal protein DnaI; Reviewed; Region: PRK08939 176279003977 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 176279003978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279003979 Walker A motif; other site 176279003980 ATP binding site [chemical binding]; other site 176279003981 Walker B motif; other site 176279003982 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 176279003983 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 176279003984 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 176279003985 ATP cone domain; Region: ATP-cone; pfam03477 176279003986 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 176279003987 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 176279003988 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 176279003989 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 176279003990 dephospho-CoA kinase; Region: TIGR00152 176279003991 CoA-binding site [chemical binding]; other site 176279003992 ATP-binding [chemical binding]; other site 176279003993 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 176279003994 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 176279003995 DNA binding site [nucleotide binding] 176279003996 catalytic residue [active] 176279003997 H2TH interface [polypeptide binding]; other site 176279003998 putative catalytic residues [active] 176279003999 turnover-facilitating residue; other site 176279004000 intercalation triad [nucleotide binding]; other site 176279004001 8OG recognition residue [nucleotide binding]; other site 176279004002 putative reading head residues; other site 176279004003 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 176279004004 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 176279004005 DNA polymerase I; Provisional; Region: PRK05755 176279004006 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 176279004007 active site 176279004008 metal binding site 1 [ion binding]; metal-binding site 176279004009 putative 5' ssDNA interaction site; other site 176279004010 metal binding site 3; metal-binding site 176279004011 metal binding site 2 [ion binding]; metal-binding site 176279004012 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 176279004013 putative DNA binding site [nucleotide binding]; other site 176279004014 putative metal binding site [ion binding]; other site 176279004015 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 176279004016 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 176279004017 active site 176279004018 DNA binding site [nucleotide binding] 176279004019 catalytic site [active] 176279004020 HAMP domain; Region: HAMP; pfam00672 176279004021 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 176279004022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176279004023 dimer interface [polypeptide binding]; other site 176279004024 phosphorylation site [posttranslational modification] 176279004025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279004026 ATP binding site [chemical binding]; other site 176279004027 Mg2+ binding site [ion binding]; other site 176279004028 G-X-G motif; other site 176279004029 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176279004030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279004031 active site 176279004032 phosphorylation site [posttranslational modification] 176279004033 intermolecular recognition site; other site 176279004034 dimerization interface [polypeptide binding]; other site 176279004035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176279004036 DNA binding site [nucleotide binding] 176279004037 isocitrate dehydrogenase; Reviewed; Region: PRK07006 176279004038 isocitrate dehydrogenase; Validated; Region: PRK07362 176279004039 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 176279004040 dimer interface [polypeptide binding]; other site 176279004041 Citrate synthase; Region: Citrate_synt; pfam00285 176279004042 active site 176279004043 citrylCoA binding site [chemical binding]; other site 176279004044 oxalacetate/citrate binding site [chemical binding]; other site 176279004045 coenzyme A binding site [chemical binding]; other site 176279004046 catalytic triad [active] 176279004047 Transposase, Mutator family; Region: Transposase_mut; pfam00872 176279004048 MULE transposase domain; Region: MULE; pfam10551 176279004049 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 176279004050 pyruvate kinase; Provisional; Region: PRK06354 176279004051 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 176279004052 domain interfaces; other site 176279004053 active site 176279004054 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 176279004055 6-phosphofructokinase; Provisional; Region: PRK03202 176279004056 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 176279004057 active site 176279004058 ADP/pyrophosphate binding site [chemical binding]; other site 176279004059 dimerization interface [polypeptide binding]; other site 176279004060 allosteric effector site; other site 176279004061 fructose-1,6-bisphosphate binding site; other site 176279004062 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 176279004063 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 176279004064 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 176279004065 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 176279004066 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 176279004067 Malic enzyme, N-terminal domain; Region: malic; pfam00390 176279004068 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 176279004069 putative NAD(P) binding site [chemical binding]; other site 176279004070 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 176279004071 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 176279004072 active site 176279004073 PHP Thumb interface [polypeptide binding]; other site 176279004074 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 176279004075 generic binding surface I; other site 176279004076 generic binding surface II; other site 176279004077 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 176279004078 DHH family; Region: DHH; pfam01368 176279004079 DHHA1 domain; Region: DHHA1; pfam02272 176279004080 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 176279004081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 176279004082 DNA-binding site [nucleotide binding]; DNA binding site 176279004083 DRTGG domain; Region: DRTGG; pfam07085 176279004084 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 176279004085 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 176279004086 active site 2 [active] 176279004087 active site 1 [active] 176279004088 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 176279004089 Ligand Binding Site [chemical binding]; other site 176279004090 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 176279004091 metal-dependent hydrolase; Provisional; Region: PRK00685 176279004092 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 176279004093 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 176279004094 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 176279004095 active site 176279004096 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 176279004097 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 176279004098 hexamer interface [polypeptide binding]; other site 176279004099 ligand binding site [chemical binding]; other site 176279004100 putative active site [active] 176279004101 NAD(P) binding site [chemical binding]; other site 176279004102 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 176279004103 Ligand Binding Site [chemical binding]; other site 176279004104 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 176279004105 propionate/acetate kinase; Provisional; Region: PRK12379 176279004106 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 176279004107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279004108 S-adenosylmethionine binding site [chemical binding]; other site 176279004109 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 176279004110 dimer interface [polypeptide binding]; other site 176279004111 catalytic triad [active] 176279004112 peroxidatic and resolving cysteines [active] 176279004113 hypothetical protein; Provisional; Region: PRK10621 176279004114 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 176279004115 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 176279004116 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 176279004117 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 176279004118 Ligand Binding Site [chemical binding]; other site 176279004119 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 176279004120 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 176279004121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176279004122 catalytic residue [active] 176279004123 septation ring formation regulator EzrA; Provisional; Region: PRK04778 176279004124 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 176279004125 GAF domain; Region: GAF_2; pfam13185 176279004126 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 176279004127 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 176279004128 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176279004129 RNA binding surface [nucleotide binding]; other site 176279004130 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 176279004131 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 176279004132 active site 176279004133 catalytic site [active] 176279004134 OsmC-like protein; Region: OsmC; cl00767 176279004135 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 176279004136 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 176279004137 catalytic residue [active] 176279004138 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 176279004139 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 176279004140 ligand binding site [chemical binding]; other site 176279004141 NAD binding site [chemical binding]; other site 176279004142 dimerization interface [polypeptide binding]; other site 176279004143 catalytic site [active] 176279004144 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 176279004145 putative L-serine binding site [chemical binding]; other site 176279004146 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 176279004147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279004148 motif II; other site 176279004149 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 176279004150 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176279004151 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176279004152 active site turn [active] 176279004153 phosphorylation site [posttranslational modification] 176279004154 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 176279004155 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 176279004156 putative acyl-acceptor binding pocket; other site 176279004157 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 176279004158 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 176279004159 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 176279004160 protein binding site [polypeptide binding]; other site 176279004161 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 176279004162 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 176279004163 active site 176279004164 HIGH motif; other site 176279004165 dimer interface [polypeptide binding]; other site 176279004166 KMSKS motif; other site 176279004167 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176279004168 RNA binding surface [nucleotide binding]; other site 176279004169 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 176279004170 Transglycosylase; Region: Transgly; pfam00912 176279004171 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 176279004172 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 176279004173 Potassium binding sites [ion binding]; other site 176279004174 Cesium cation binding sites [ion binding]; other site 176279004175 catabolite control protein A; Region: ccpA; TIGR01481 176279004176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 176279004177 DNA binding site [nucleotide binding] 176279004178 domain linker motif; other site 176279004179 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 176279004180 dimerization interface [polypeptide binding]; other site 176279004181 effector binding site; other site 176279004182 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 176279004183 Chorismate mutase type II; Region: CM_2; cl00693 176279004184 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 176279004185 YtxH-like protein; Region: YtxH; pfam12732 176279004186 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 176279004187 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 176279004188 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 176279004189 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176279004190 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176279004191 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 176279004192 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 176279004193 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 176279004194 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 176279004195 putative tRNA-binding site [nucleotide binding]; other site 176279004196 hypothetical protein; Provisional; Region: PRK13668 176279004197 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176279004198 catalytic residues [active] 176279004199 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 176279004200 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 176279004201 oligomer interface [polypeptide binding]; other site 176279004202 active site 176279004203 metal binding site [ion binding]; metal-binding site 176279004204 Predicted small secreted protein [Function unknown]; Region: COG5584 176279004205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279004206 S-adenosylmethionine binding site [chemical binding]; other site 176279004207 Phosphotransferase enzyme family; Region: APH; pfam01636 176279004208 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 176279004209 active site 176279004210 substrate binding site [chemical binding]; other site 176279004211 ATP binding site [chemical binding]; other site 176279004212 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 176279004213 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 176279004214 homodimer interface [polypeptide binding]; other site 176279004215 substrate-cofactor binding pocket; other site 176279004216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279004217 catalytic residue [active] 176279004218 dipeptidase PepV; Reviewed; Region: PRK07318 176279004219 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 176279004220 active site 176279004221 metal binding site [ion binding]; metal-binding site 176279004222 YtxH-like protein; Region: YtxH; pfam12732 176279004223 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 176279004224 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 176279004225 RNA binding surface [nucleotide binding]; other site 176279004226 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 176279004227 active site 176279004228 uracil binding [chemical binding]; other site 176279004229 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 176279004230 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 176279004231 HI0933-like protein; Region: HI0933_like; pfam03486 176279004232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176279004233 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176279004234 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 176279004235 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004236 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004237 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004238 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004239 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004240 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004241 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004242 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004243 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004244 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004245 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004246 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004247 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004248 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004249 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004250 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004251 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004252 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004253 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004254 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004255 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004256 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004257 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004258 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004259 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004260 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004261 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004262 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004263 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004264 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004265 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004266 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 176279004267 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176279004268 active site residue [active] 176279004269 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 176279004270 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 176279004271 HIGH motif; other site 176279004272 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 176279004273 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 176279004274 active site 176279004275 KMSKS motif; other site 176279004276 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 176279004277 tRNA binding surface [nucleotide binding]; other site 176279004278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279004279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279004280 putative substrate translocation pore; other site 176279004281 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 176279004282 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 176279004283 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176279004284 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 176279004285 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 176279004286 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 176279004287 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 176279004288 homopentamer interface [polypeptide binding]; other site 176279004289 active site 176279004290 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 176279004291 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 176279004292 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 176279004293 dimerization interface [polypeptide binding]; other site 176279004294 active site 176279004295 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 176279004296 Lumazine binding domain; Region: Lum_binding; pfam00677 176279004297 Lumazine binding domain; Region: Lum_binding; pfam00677 176279004298 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 176279004299 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 176279004300 catalytic motif [active] 176279004301 Zn binding site [ion binding]; other site 176279004302 RibD C-terminal domain; Region: RibD_C; pfam01872 176279004303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 176279004304 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 176279004305 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 176279004306 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 176279004307 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 176279004308 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 176279004309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 176279004310 DNA binding residues [nucleotide binding] 176279004311 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 176279004312 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 176279004313 active site 176279004314 intersubunit interactions; other site 176279004315 catalytic residue [active] 176279004316 camphor resistance protein CrcB; Provisional; Region: PRK14201 176279004317 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 176279004318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279004319 S-adenosylmethionine binding site [chemical binding]; other site 176279004320 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 176279004321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279004322 S-adenosylmethionine binding site [chemical binding]; other site 176279004323 aminoglycoside resistance protein; Provisional; Region: PRK13746 176279004324 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 176279004325 active site 176279004326 NTP binding site [chemical binding]; other site 176279004327 metal binding triad [ion binding]; metal-binding site 176279004328 antibiotic binding site [chemical binding]; other site 176279004329 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 176279004330 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 176279004331 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 176279004332 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 176279004333 Int/Topo IB signature motif; other site 176279004334 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 176279004335 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 176279004336 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 176279004337 Int/Topo IB signature motif; other site 176279004338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279004339 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279004340 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 176279004341 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 176279004342 active site 176279004343 catalytic tetrad [active] 176279004344 S-adenosylmethionine synthetase; Validated; Region: PRK05250 176279004345 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 176279004346 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 176279004347 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 176279004348 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 176279004349 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 176279004350 active site 176279004351 substrate-binding site [chemical binding]; other site 176279004352 metal-binding site [ion binding] 176279004353 ATP binding site [chemical binding]; other site 176279004354 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 176279004355 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 176279004356 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 176279004357 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 176279004358 nudix motif; other site 176279004359 Haemolytic domain; Region: Haemolytic; pfam01809 176279004360 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 176279004361 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 176279004362 metal binding site [ion binding]; metal-binding site 176279004363 substrate binding pocket [chemical binding]; other site 176279004364 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 176279004365 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 176279004366 acyl-activating enzyme (AAE) consensus motif; other site 176279004367 putative AMP binding site [chemical binding]; other site 176279004368 putative active site [active] 176279004369 putative CoA binding site [chemical binding]; other site 176279004370 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 176279004371 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 176279004372 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 176279004373 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 176279004374 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 176279004375 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 176279004376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 176279004377 ferrochelatase; Provisional; Region: PRK12435 176279004378 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 176279004379 C-terminal domain interface [polypeptide binding]; other site 176279004380 active site 176279004381 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 176279004382 active site 176279004383 N-terminal domain interface [polypeptide binding]; other site 176279004384 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 176279004385 substrate binding site [chemical binding]; other site 176279004386 active site 176279004387 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 176279004388 Cadmium resistance transporter; Region: Cad; pfam03596 176279004389 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 176279004390 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 176279004391 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176279004392 Walker A/P-loop; other site 176279004393 ATP binding site [chemical binding]; other site 176279004394 Q-loop/lid; other site 176279004395 ABC transporter signature motif; other site 176279004396 Walker B; other site 176279004397 D-loop; other site 176279004398 H-loop/switch region; other site 176279004399 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 176279004400 HIT family signature motif; other site 176279004401 catalytic residue [active] 176279004402 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 176279004403 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 176279004404 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 176279004405 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 176279004406 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 176279004407 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 176279004408 generic binding surface II; other site 176279004409 generic binding surface I; other site 176279004410 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176279004411 Zn2+ binding site [ion binding]; other site 176279004412 Mg2+ binding site [ion binding]; other site 176279004413 Uncharacterized conserved protein [Function unknown]; Region: COG4717 176279004414 P-loop containing region of AAA domain; Region: AAA_29; cl17516 176279004415 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 176279004416 Peptidase family M48; Region: Peptidase_M48; cl12018 176279004417 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 176279004418 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 176279004419 active site 176279004420 metal binding site [ion binding]; metal-binding site 176279004421 DNA binding site [nucleotide binding] 176279004422 hypothetical protein; Provisional; Region: PRK13676 176279004423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 176279004424 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 176279004425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 176279004426 non-specific DNA binding site [nucleotide binding]; other site 176279004427 salt bridge; other site 176279004428 sequence-specific DNA binding site [nucleotide binding]; other site 176279004429 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 176279004430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279004431 active site 176279004432 phosphorylation site [posttranslational modification] 176279004433 intermolecular recognition site; other site 176279004434 dimerization interface [polypeptide binding]; other site 176279004435 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 176279004436 DNA binding residues [nucleotide binding] 176279004437 dimerization interface [polypeptide binding]; other site 176279004438 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 176279004439 GAF domain; Region: GAF_3; pfam13492 176279004440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 176279004441 Histidine kinase; Region: HisKA_3; pfam07730 176279004442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279004443 ATP binding site [chemical binding]; other site 176279004444 Mg2+ binding site [ion binding]; other site 176279004445 G-X-G motif; other site 176279004446 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 176279004447 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 176279004448 active site 176279004449 fumarate hydratase; Reviewed; Region: fumC; PRK00485 176279004450 Class II fumarases; Region: Fumarase_classII; cd01362 176279004451 active site 176279004452 tetramer interface [polypeptide binding]; other site 176279004453 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 176279004454 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 176279004455 active site 176279004456 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 176279004457 epoxyqueuosine reductase; Region: TIGR00276 176279004458 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 176279004459 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 176279004460 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 176279004461 Walker A/P-loop; other site 176279004462 ATP binding site [chemical binding]; other site 176279004463 Q-loop/lid; other site 176279004464 ABC transporter signature motif; other site 176279004465 Walker B; other site 176279004466 D-loop; other site 176279004467 H-loop/switch region; other site 176279004468 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 176279004469 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 176279004470 substrate binding pocket [chemical binding]; other site 176279004471 membrane-bound complex binding site; other site 176279004472 hinge residues; other site 176279004473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279004474 dimer interface [polypeptide binding]; other site 176279004475 conserved gate region; other site 176279004476 ABC-ATPase subunit interface; other site 176279004477 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 176279004478 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 176279004479 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 176279004480 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 176279004481 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 176279004482 metal binding site 2 [ion binding]; metal-binding site 176279004483 putative DNA binding helix; other site 176279004484 metal binding site 1 [ion binding]; metal-binding site 176279004485 dimer interface [polypeptide binding]; other site 176279004486 structural Zn2+ binding site [ion binding]; other site 176279004487 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 176279004488 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 176279004489 putative ligand binding site [chemical binding]; other site 176279004490 NAD binding site [chemical binding]; other site 176279004491 catalytic site [active] 176279004492 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 176279004493 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 176279004494 catalytic triad [active] 176279004495 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 176279004496 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176279004497 inhibitor-cofactor binding pocket; inhibition site 176279004498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279004499 catalytic residue [active] 176279004500 Predicted membrane protein [Function unknown]; Region: COG4129 176279004501 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 176279004502 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 176279004503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 176279004504 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 176279004505 Walker A/P-loop; other site 176279004506 ATP binding site [chemical binding]; other site 176279004507 Q-loop/lid; other site 176279004508 ABC transporter signature motif; other site 176279004509 Walker B; other site 176279004510 D-loop; other site 176279004511 H-loop/switch region; other site 176279004512 hypothetical protein; Provisional; Region: PRK13662 176279004513 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 176279004514 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 176279004515 minor groove reading motif; other site 176279004516 helix-hairpin-helix signature motif; other site 176279004517 substrate binding pocket [chemical binding]; other site 176279004518 active site 176279004519 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 176279004520 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 176279004521 DNA binding and oxoG recognition site [nucleotide binding] 176279004522 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 176279004523 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 176279004524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279004525 Walker A/P-loop; other site 176279004526 ATP binding site [chemical binding]; other site 176279004527 Q-loop/lid; other site 176279004528 ABC transporter signature motif; other site 176279004529 Walker B; other site 176279004530 D-loop; other site 176279004531 H-loop/switch region; other site 176279004532 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 176279004533 recombination regulator RecX; Provisional; Region: recX; PRK14135 176279004534 glycosyltransferase; Provisional; Region: PRK13481 176279004535 Transglycosylase; Region: Transgly; pfam00912 176279004536 intracellular protease, PfpI family; Region: PfpI; TIGR01382 176279004537 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 176279004538 proposed catalytic triad [active] 176279004539 conserved cys residue [active] 176279004540 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 176279004541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279004542 FeS/SAM binding site; other site 176279004543 YfkB-like domain; Region: YfkB; pfam08756 176279004544 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 176279004545 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 176279004546 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 176279004547 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 176279004548 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 176279004549 Low molecular weight phosphatase family; Region: LMWPc; cd00115 176279004550 active site 176279004551 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 176279004552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 176279004553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279004554 active site 176279004555 phosphorylation site [posttranslational modification] 176279004556 intermolecular recognition site; other site 176279004557 dimerization interface [polypeptide binding]; other site 176279004558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 176279004559 DNA binding residues [nucleotide binding] 176279004560 dimerization interface [polypeptide binding]; other site 176279004561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 176279004562 Histidine kinase; Region: HisKA_3; pfam07730 176279004563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279004564 ATP binding site [chemical binding]; other site 176279004565 Mg2+ binding site [ion binding]; other site 176279004566 G-X-G motif; other site 176279004567 Predicted membrane protein [Function unknown]; Region: COG4758 176279004568 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 176279004569 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 176279004570 active site 176279004571 Predicted membrane protein [Function unknown]; Region: COG4129 176279004572 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 176279004573 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 176279004574 catalytic triad [active] 176279004575 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 176279004576 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176279004577 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 176279004578 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 176279004579 Ferritin-like domain; Region: Ferritin; pfam00210 176279004580 ferroxidase diiron center [ion binding]; other site 176279004581 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 176279004582 active site 176279004583 catalytic site [active] 176279004584 substrate binding site [chemical binding]; other site 176279004585 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 176279004586 active site 176279004587 DNA polymerase IV; Validated; Region: PRK02406 176279004588 DNA binding site [nucleotide binding] 176279004589 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 176279004590 TRAM domain; Region: TRAM; cl01282 176279004591 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 176279004592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279004593 S-adenosylmethionine binding site [chemical binding]; other site 176279004594 putative lipid kinase; Reviewed; Region: PRK13337 176279004595 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 176279004596 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 176279004597 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 176279004598 GatB domain; Region: GatB_Yqey; pfam02637 176279004599 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 176279004600 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 176279004601 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 176279004602 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 176279004603 Na binding site [ion binding]; other site 176279004604 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 176279004605 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 176279004606 putative dimer interface [polypeptide binding]; other site 176279004607 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 176279004608 putative dimer interface [polypeptide binding]; other site 176279004609 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 176279004610 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 176279004611 nucleotide binding pocket [chemical binding]; other site 176279004612 K-X-D-G motif; other site 176279004613 catalytic site [active] 176279004614 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 176279004615 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 176279004616 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 176279004617 Dimer interface [polypeptide binding]; other site 176279004618 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 176279004619 Part of AAA domain; Region: AAA_19; pfam13245 176279004620 Family description; Region: UvrD_C_2; pfam13538 176279004621 PcrB family; Region: PcrB; pfam01884 176279004622 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 176279004623 substrate binding site [chemical binding]; other site 176279004624 putative active site [active] 176279004625 dimer interface [polypeptide binding]; other site 176279004626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 176279004627 adenylosuccinate lyase; Provisional; Region: PRK07492 176279004628 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 176279004629 tetramer interface [polypeptide binding]; other site 176279004630 active site 176279004631 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 176279004632 NETI protein; Region: NETI; pfam14044 176279004633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 176279004634 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 176279004635 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 176279004636 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 176279004637 homodimer interface [polypeptide binding]; other site 176279004638 NAD binding pocket [chemical binding]; other site 176279004639 ATP binding pocket [chemical binding]; other site 176279004640 Mg binding site [ion binding]; other site 176279004641 active-site loop [active] 176279004642 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 176279004643 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 176279004644 active site 176279004645 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 176279004646 active site 176279004647 dimer interface [polypeptide binding]; other site 176279004648 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 176279004649 Prephenate dehydratase; Region: PDT; pfam00800 176279004650 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 176279004651 putative L-Phe binding site [chemical binding]; other site 176279004652 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 176279004653 Isochorismatase family; Region: Isochorismatase; pfam00857 176279004654 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 176279004655 catalytic triad [active] 176279004656 conserved cis-peptide bond; other site 176279004657 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 176279004658 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 176279004659 DHHA2 domain; Region: DHHA2; pfam02833 176279004660 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 176279004661 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 176279004662 NAD(P) binding site [chemical binding]; other site 176279004663 catalytic residues [active] 176279004664 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 176279004665 Predicted transcriptional regulator [Transcription]; Region: COG3682 176279004666 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 176279004667 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 176279004668 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 176279004669 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 176279004670 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 176279004671 Int/Topo IB signature motif; other site 176279004672 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 176279004673 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 176279004674 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 176279004675 Int/Topo IB signature motif; other site 176279004676 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 176279004677 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 176279004678 active site 176279004679 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 176279004680 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 176279004681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 176279004682 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176279004683 Walker A/P-loop; other site 176279004684 ATP binding site [chemical binding]; other site 176279004685 Q-loop/lid; other site 176279004686 ABC transporter signature motif; other site 176279004687 Walker B; other site 176279004688 D-loop; other site 176279004689 H-loop/switch region; other site 176279004690 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 176279004691 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 176279004692 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176279004693 Walker A/P-loop; other site 176279004694 ATP binding site [chemical binding]; other site 176279004695 Q-loop/lid; other site 176279004696 ABC transporter signature motif; other site 176279004697 Walker B; other site 176279004698 D-loop; other site 176279004699 H-loop/switch region; other site 176279004700 Predicted transcriptional regulators [Transcription]; Region: COG1725 176279004701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 176279004702 DNA-binding site [nucleotide binding]; DNA binding site 176279004703 hypothetical protein; Provisional; Region: PRK08637 176279004704 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 176279004705 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 176279004706 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 176279004707 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 176279004708 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 176279004709 ring oligomerisation interface [polypeptide binding]; other site 176279004710 ATP/Mg binding site [chemical binding]; other site 176279004711 stacking interactions; other site 176279004712 hinge regions; other site 176279004713 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 176279004714 oligomerisation interface [polypeptide binding]; other site 176279004715 mobile loop; other site 176279004716 roof hairpin; other site 176279004717 CAAX protease self-immunity; Region: Abi; pfam02517 176279004718 Predicted amidohydrolase [General function prediction only]; Region: COG0388 176279004719 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 176279004720 putative active site [active] 176279004721 catalytic triad [active] 176279004722 putative dimer interface [polypeptide binding]; other site 176279004723 delta-hemolysin; Provisional; Region: PRK14752 176279004724 Accessory gene regulator B; Region: AgrB; smart00793 176279004725 Staphylococcal AgrD protein; Region: AgrD; pfam05931 176279004726 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 176279004727 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 176279004728 ATP binding site [chemical binding]; other site 176279004729 Mg2+ binding site [ion binding]; other site 176279004730 G-X-G motif; other site 176279004731 Response regulator receiver domain; Region: Response_reg; pfam00072 176279004732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279004733 active site 176279004734 phosphorylation site [posttranslational modification] 176279004735 intermolecular recognition site; other site 176279004736 dimerization interface [polypeptide binding]; other site 176279004737 LytTr DNA-binding domain; Region: LytTR; pfam04397 176279004738 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 176279004739 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 176279004740 putative substrate binding site [chemical binding]; other site 176279004741 putative ATP binding site [chemical binding]; other site 176279004742 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 176279004743 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 176279004744 substrate binding [chemical binding]; other site 176279004745 active site 176279004746 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 176279004747 Transcriptional regulators [Transcription]; Region: PurR; COG1609 176279004748 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 176279004749 DNA binding site [nucleotide binding] 176279004750 domain linker motif; other site 176279004751 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 176279004752 dimerization interface [polypeptide binding]; other site 176279004753 ligand binding site [chemical binding]; other site 176279004754 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 176279004755 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 176279004756 CPxP motif; other site 176279004757 Staphylococcus epidermidis RP62A phage SP-beta 176279004758 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176279004759 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 176279004760 catalytic residues [active] 176279004761 catalytic nucleophile [active] 176279004762 Recombinase; Region: Recombinase; pfam07508 176279004763 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 176279004764 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 176279004765 putative nucleotide binding site [chemical binding]; other site 176279004766 putative metal binding site [ion binding]; other site 176279004767 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176279004768 catalytic residues [active] 176279004769 hypothetical protein; Provisional; Region: PRK01184 176279004770 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 176279004771 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 176279004772 dimer interface [polypeptide binding]; other site 176279004773 putative radical transfer pathway; other site 176279004774 diiron center [ion binding]; other site 176279004775 tyrosyl radical; other site 176279004776 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 176279004777 NUMOD4 motif; Region: NUMOD4; pfam07463 176279004778 HNH endonuclease; Region: HNH_3; pfam13392 176279004779 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 176279004780 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 176279004781 Region: intein 176279004782 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 176279004783 protein-splicing catalytic site; other site 176279004784 thioester formation/cholesterol transfer; other site 176279004785 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 176279004786 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 176279004787 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 176279004788 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 176279004789 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 176279004790 hypothetical protein; Region: PHA02246 176279004791 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 176279004792 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 176279004793 cofactor binding site; other site 176279004794 DNA binding site [nucleotide binding] 176279004795 substrate interaction site [chemical binding]; other site 176279004796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279004797 S-adenosylmethionine binding site [chemical binding]; other site 176279004798 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 176279004799 putative peptide-modifying radical SAM enzyme, AF0577 family; Region: rSAM_AF0577; TIGR04084 176279004800 DNA ligase; Provisional; Region: 30; PHA02587 176279004801 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 176279004802 DNA binding site [nucleotide binding] 176279004803 active site 176279004804 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 176279004805 DNA binding site [nucleotide binding] 176279004806 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 176279004807 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 176279004808 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 176279004809 active site 176279004810 YolD-like protein; Region: YolD; pfam08863 176279004811 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 176279004812 active site 176279004813 metal binding site [ion binding]; metal-binding site 176279004814 Fic/DOC family; Region: Fic; cl00960 176279004815 Dynein, heavy chain [Cytoskeleton]; Region: DYN1; COG5245 176279004816 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 176279004817 putative active site [active] 176279004818 putative metal binding site [ion binding]; other site 176279004819 Chordopoxvirus A35R protein; Region: Chordopox_A35R; cl17411 176279004820 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 176279004821 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 176279004822 active site 176279004823 metal binding site [ion binding]; metal-binding site 176279004824 Transcriptional activator RinB; Region: RinB; pfam06116 176279004825 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 176279004826 Catalytic site; other site 176279004827 YopX protein; Region: YopX; cl09859 176279004828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176279004829 Integrase core domain; Region: rve; pfam00665 176279004830 EDD domain protein, DegV family; Region: DegV; TIGR00762 176279004831 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 176279004832 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 176279004833 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 176279004834 folate binding site [chemical binding]; other site 176279004835 NADP+ binding site [chemical binding]; other site 176279004836 thymidylate synthase; Region: thym_sym; TIGR03284 176279004837 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 176279004838 dimerization interface [polypeptide binding]; other site 176279004839 active site 176279004840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176279004841 Integrase core domain; Region: rve; pfam00665 176279004842 Transposase, Mutator family; Region: Transposase_mut; pfam00872 176279004843 MULE transposase domain; Region: MULE; pfam10551 176279004844 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 176279004845 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 176279004846 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 176279004847 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 176279004848 Phosphotransferase enzyme family; Region: APH; pfam01636 176279004849 active site 176279004850 ATP binding site [chemical binding]; other site 176279004851 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 176279004852 substrate binding site [chemical binding]; other site 176279004853 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 176279004854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279004855 Coenzyme A binding pocket [chemical binding]; other site 176279004856 Transposase, Mutator family; Region: Transposase_mut; pfam00872 176279004857 MULE transposase domain; Region: MULE; pfam10551 176279004858 Integrase core domain; Region: rve; pfam00665 176279004859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176279004860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 176279004861 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 176279004862 DHH family; Region: DHH; pfam01368 176279004863 hypothetical protein; Provisional; Region: PRK08624 176279004864 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 176279004865 active site 176279004866 metal binding site [ion binding]; metal-binding site 176279004867 interdomain interaction site; other site 176279004868 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 176279004869 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 176279004870 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 176279004871 ATP binding site [chemical binding]; other site 176279004872 Walker B motif; other site 176279004873 AAA domain; Region: AAA_24; pfam13479 176279004874 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 176279004875 DNA-sulfur modification-associated; Region: DndB; pfam14072 176279004876 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 176279004877 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 176279004878 active site 176279004879 catalytic residues [active] 176279004880 DNA binding site [nucleotide binding] 176279004881 Int/Topo IB signature motif; other site 176279004882 Antirestriction protein (ArdA); Region: ArdA; pfam07275 176279004883 AAA domain; Region: AAA_30; pfam13604 176279004884 Family description; Region: UvrD_C_2; pfam13538 176279004885 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 176279004886 IHF dimer interface [polypeptide binding]; other site 176279004887 IHF - DNA interface [nucleotide binding]; other site 176279004888 YonK protein; Region: YonK; pfam09642 176279004889 large terminase protein; Provisional; Region: 17; PHA02533 176279004890 Terminase-like family; Region: Terminase_6; pfam03237 176279004891 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 176279004892 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 176279004893 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 176279004894 active site 176279004895 catalytic residues [active] 176279004896 DNA binding site [nucleotide binding] 176279004897 Int/Topo IB signature motif; other site 176279004898 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 176279004899 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 176279004900 Peptidase family M23; Region: Peptidase_M23; pfam01551 176279004901 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 176279004902 V-type ATP synthase subunit I; Validated; Region: PRK05771 176279004903 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional; Region: PLN03229 176279004904 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 176279004905 Phage-related protein [Function unknown]; Region: PblB; COG4926 176279004906 AAA domain; Region: AAA_13; pfam13166 176279004907 Phage-related protein [Function unknown]; Region: PblB; COG4926 176279004908 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 176279004909 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 176279004910 Phage lysis protein, holin; Region: Phage_holin; pfam04688 176279004911 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 176279004912 active site 176279004913 catalytic triad [active] 176279004914 oxyanion hole [active] 176279004915 CHAP domain; Region: CHAP; pfam05257 176279004916 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 176279004917 active site 176279004918 metal binding site [ion binding]; metal-binding site 176279004919 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 176279004920 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 176279004921 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 176279004922 CoA binding domain; Region: CoA_binding; pfam02629 176279004923 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 176279004924 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176279004925 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176279004926 ABC transporter; Region: ABC_tran_2; pfam12848 176279004927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 176279004928 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 176279004929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279004930 Walker A/P-loop; other site 176279004931 ATP binding site [chemical binding]; other site 176279004932 Q-loop/lid; other site 176279004933 ABC transporter signature motif; other site 176279004934 Walker B; other site 176279004935 D-loop; other site 176279004936 H-loop/switch region; other site 176279004937 UGMP family protein; Validated; Region: PRK09604 176279004938 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 176279004939 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 176279004940 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 176279004941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279004942 Coenzyme A binding pocket [chemical binding]; other site 176279004943 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 176279004944 Glycoprotease family; Region: Peptidase_M22; pfam00814 176279004945 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 176279004946 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 176279004947 6-phosphogluconate dehydratase; Region: edd; TIGR01196 176279004948 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 176279004949 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 176279004950 PYR/PP interface [polypeptide binding]; other site 176279004951 dimer interface [polypeptide binding]; other site 176279004952 TPP binding site [chemical binding]; other site 176279004953 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 176279004954 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 176279004955 TPP-binding site [chemical binding]; other site 176279004956 dimer interface [polypeptide binding]; other site 176279004957 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 176279004958 ketol-acid reductoisomerase; Provisional; Region: PRK05479 176279004959 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 176279004960 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 176279004961 2-isopropylmalate synthase; Validated; Region: PRK00915 176279004962 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 176279004963 active site 176279004964 catalytic residues [active] 176279004965 metal binding site [ion binding]; metal-binding site 176279004966 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 176279004967 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 176279004968 tartrate dehydrogenase; Region: TTC; TIGR02089 176279004969 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 176279004970 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 176279004971 substrate binding site [chemical binding]; other site 176279004972 ligand binding site [chemical binding]; other site 176279004973 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 176279004974 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 176279004975 substrate binding site [chemical binding]; other site 176279004976 threonine dehydratase; Validated; Region: PRK08639 176279004977 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 176279004978 tetramer interface [polypeptide binding]; other site 176279004979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279004980 catalytic residue [active] 176279004981 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 176279004982 putative Ile/Val binding site [chemical binding]; other site 176279004983 hypothetical protein; Provisional; Region: PRK04351 176279004984 SprT homologues; Region: SprT; cl01182 176279004985 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 176279004986 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 176279004987 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 176279004988 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 176279004989 RNA binding site [nucleotide binding]; other site 176279004990 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 176279004991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 176279004992 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 176279004993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 176279004994 DNA binding residues [nucleotide binding] 176279004995 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 176279004996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279004997 ATP binding site [chemical binding]; other site 176279004998 Mg2+ binding site [ion binding]; other site 176279004999 G-X-G motif; other site 176279005000 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 176279005001 anti sigma factor interaction site; other site 176279005002 regulatory phosphorylation site [posttranslational modification]; other site 176279005003 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 176279005004 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 176279005005 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 176279005006 PemK-like protein; Region: PemK; pfam02452 176279005007 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 176279005008 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 176279005009 active site 176279005010 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176279005011 dimer interface [polypeptide binding]; other site 176279005012 substrate binding site [chemical binding]; other site 176279005013 catalytic residues [active] 176279005014 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 176279005015 Uncharacterized conserved protein [Function unknown]; Region: COG3402 176279005016 Predicted membrane protein [Function unknown]; Region: COG3428 176279005017 Bacterial PH domain; Region: DUF304; pfam03703 176279005018 Bacterial PH domain; Region: DUF304; pfam03703 176279005019 Bacterial PH domain; Region: DUF304; cl01348 176279005020 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 176279005021 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 176279005022 ATP binding site [chemical binding]; other site 176279005023 Mg++ binding site [ion binding]; other site 176279005024 motif III; other site 176279005025 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279005026 nucleotide binding region [chemical binding]; other site 176279005027 ATP-binding site [chemical binding]; other site 176279005028 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 176279005029 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 176279005030 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176279005031 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 176279005032 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 176279005033 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 176279005034 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 176279005035 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 176279005036 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 176279005037 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 176279005038 putative homodimer interface [polypeptide binding]; other site 176279005039 putative homotetramer interface [polypeptide binding]; other site 176279005040 allosteric switch controlling residues; other site 176279005041 putative metal binding site [ion binding]; other site 176279005042 putative homodimer-homodimer interface [polypeptide binding]; other site 176279005043 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 176279005044 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 176279005045 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 176279005046 putative active site [active] 176279005047 catalytic site [active] 176279005048 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 176279005049 putative active site [active] 176279005050 catalytic site [active] 176279005051 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 176279005052 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 176279005053 Zn2+ binding site [ion binding]; other site 176279005054 Mg2+ binding site [ion binding]; other site 176279005055 OxaA-like protein precursor; Provisional; Region: PRK02463 176279005056 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 176279005057 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 176279005058 thiamine phosphate binding site [chemical binding]; other site 176279005059 active site 176279005060 pyrophosphate binding site [ion binding]; other site 176279005061 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 176279005062 substrate binding site [chemical binding]; other site 176279005063 multimerization interface [polypeptide binding]; other site 176279005064 ATP binding site [chemical binding]; other site 176279005065 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 176279005066 dimer interface [polypeptide binding]; other site 176279005067 substrate binding site [chemical binding]; other site 176279005068 ATP binding site [chemical binding]; other site 176279005069 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 176279005070 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 176279005071 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 176279005072 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 176279005073 dimer interface [polypeptide binding]; other site 176279005074 ssDNA binding site [nucleotide binding]; other site 176279005075 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176279005076 YwpF-like protein; Region: YwpF; pfam14183 176279005077 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 176279005078 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 176279005079 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 176279005080 hinge; other site 176279005081 active site 176279005082 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 176279005083 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 176279005084 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 176279005085 gamma subunit interface [polypeptide binding]; other site 176279005086 epsilon subunit interface [polypeptide binding]; other site 176279005087 LBP interface [polypeptide binding]; other site 176279005088 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 176279005089 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 176279005090 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 176279005091 alpha subunit interaction interface [polypeptide binding]; other site 176279005092 Walker A motif; other site 176279005093 ATP binding site [chemical binding]; other site 176279005094 Walker B motif; other site 176279005095 inhibitor binding site; inhibition site 176279005096 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 176279005097 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 176279005098 core domain interface [polypeptide binding]; other site 176279005099 delta subunit interface [polypeptide binding]; other site 176279005100 epsilon subunit interface [polypeptide binding]; other site 176279005101 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 176279005102 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 176279005103 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 176279005104 beta subunit interaction interface [polypeptide binding]; other site 176279005105 Walker A motif; other site 176279005106 ATP binding site [chemical binding]; other site 176279005107 Walker B motif; other site 176279005108 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 176279005109 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 176279005110 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 176279005111 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 176279005112 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 176279005113 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 176279005114 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 176279005115 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 176279005116 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 176279005117 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 176279005118 active site 176279005119 homodimer interface [polypeptide binding]; other site 176279005120 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 176279005121 active site 176279005122 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 176279005123 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 176279005124 dimer interface [polypeptide binding]; other site 176279005125 active site 176279005126 glycine-pyridoxal phosphate binding site [chemical binding]; other site 176279005127 folate binding site [chemical binding]; other site 176279005128 hypothetical protein; Provisional; Region: PRK13690 176279005129 Low molecular weight phosphatase family; Region: LMWPc; cd00115 176279005130 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 176279005131 active site 176279005132 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 176279005133 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 176279005134 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 176279005135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279005136 S-adenosylmethionine binding site [chemical binding]; other site 176279005137 peptide chain release factor 1; Validated; Region: prfA; PRK00591 176279005138 This domain is found in peptide chain release factors; Region: PCRF; smart00937 176279005139 RF-1 domain; Region: RF-1; pfam00472 176279005140 thymidine kinase; Provisional; Region: PRK04296 176279005141 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 176279005142 transcription termination factor Rho; Provisional; Region: rho; PRK09376 176279005143 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 176279005144 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 176279005145 RNA binding site [nucleotide binding]; other site 176279005146 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 176279005147 Walker A motif; other site 176279005148 ATP binding site [chemical binding]; other site 176279005149 Walker B motif; other site 176279005150 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 176279005151 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 176279005152 NAD binding site [chemical binding]; other site 176279005153 catalytic residues [active] 176279005154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279005155 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279005156 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 176279005157 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 176279005158 hinge; other site 176279005159 active site 176279005160 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 176279005161 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 176279005162 intersubunit interface [polypeptide binding]; other site 176279005163 active site 176279005164 zinc binding site [ion binding]; other site 176279005165 Na+ binding site [ion binding]; other site 176279005166 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 176279005167 CTP synthetase; Validated; Region: pyrG; PRK05380 176279005168 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 176279005169 Catalytic site [active] 176279005170 active site 176279005171 UTP binding site [chemical binding]; other site 176279005172 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 176279005173 active site 176279005174 putative oxyanion hole; other site 176279005175 catalytic triad [active] 176279005176 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 176279005177 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 176279005178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279005179 Coenzyme A binding pocket [chemical binding]; other site 176279005180 pantothenate kinase; Provisional; Region: PRK13317 176279005181 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 176279005182 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 176279005183 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 176279005184 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176279005185 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 176279005186 metal binding site [ion binding]; metal-binding site 176279005187 S-ribosylhomocysteinase; Provisional; Region: PRK02260 176279005188 Predicted membrane protein [Function unknown]; Region: COG4270 176279005189 phosphopentomutase; Provisional; Region: PRK05362 176279005190 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 176279005191 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 176279005192 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 176279005193 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 176279005194 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 176279005195 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 176279005196 intersubunit interface [polypeptide binding]; other site 176279005197 active site 176279005198 catalytic residue [active] 176279005199 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 176279005200 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 176279005201 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 176279005202 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 176279005203 dimerization interface [polypeptide binding]; other site 176279005204 DPS ferroxidase diiron center [ion binding]; other site 176279005205 ion pore; other site 176279005206 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 176279005207 EVE domain; Region: EVE; cl00728 176279005208 EVE domain; Region: EVE; cl00728 176279005209 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 176279005210 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 176279005211 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 176279005212 NADH(P)-binding; Region: NAD_binding_10; pfam13460 176279005213 NAD(P) binding site [chemical binding]; other site 176279005214 putative active site [active] 176279005215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176279005216 dimerization interface [polypeptide binding]; other site 176279005217 putative DNA binding site [nucleotide binding]; other site 176279005218 putative Zn2+ binding site [ion binding]; other site 176279005219 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 176279005220 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 176279005221 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 176279005222 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 176279005223 active site 176279005224 metal binding site [ion binding]; metal-binding site 176279005225 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 176279005226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279005227 active site 176279005228 motif I; other site 176279005229 motif II; other site 176279005230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279005231 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 176279005232 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 176279005233 glutaminase active site [active] 176279005234 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 176279005235 dimer interface [polypeptide binding]; other site 176279005236 active site 176279005237 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 176279005238 dimer interface [polypeptide binding]; other site 176279005239 active site 176279005240 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 176279005241 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 176279005242 active site 176279005243 substrate binding site [chemical binding]; other site 176279005244 metal binding site [ion binding]; metal-binding site 176279005245 YbbR-like protein; Region: YbbR; pfam07949 176279005246 YbbR-like protein; Region: YbbR; pfam07949 176279005247 TIGR00159 family protein; Region: TIGR00159 176279005248 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 176279005249 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 176279005250 Walker A motif; other site 176279005251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005252 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279005253 putative substrate translocation pore; other site 176279005254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005255 putative transporter; Provisional; Region: PRK10504 176279005256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005257 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 176279005258 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 176279005259 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 176279005260 substrate binding site; other site 176279005261 dimerization interface; other site 176279005262 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 176279005263 YT521-B-like family; Region: YTH; pfam04146 176279005264 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13315 176279005265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 176279005266 Nucleoside recognition; Region: Gate; pfam07670 176279005267 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 176279005268 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176279005269 ABC-ATPase subunit interface; other site 176279005270 dimer interface [polypeptide binding]; other site 176279005271 putative PBP binding regions; other site 176279005272 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 176279005273 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 176279005274 ABC-ATPase subunit interface; other site 176279005275 dimer interface [polypeptide binding]; other site 176279005276 putative PBP binding regions; other site 176279005277 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 176279005278 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 176279005279 siderophore binding site; other site 176279005280 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 176279005281 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 176279005282 dimer interface [polypeptide binding]; other site 176279005283 active site 176279005284 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 176279005285 substrate binding site [chemical binding]; other site 176279005286 catalytic residue [active] 176279005287 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 176279005288 IucA / IucC family; Region: IucA_IucC; pfam04183 176279005289 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 176279005290 H+ Antiporter protein; Region: 2A0121; TIGR00900 176279005291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005292 putative substrate translocation pore; other site 176279005293 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 176279005294 IucA / IucC family; Region: IucA_IucC; pfam04183 176279005295 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 176279005296 Asp23 family; Region: Asp23; pfam03780 176279005297 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 176279005298 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 176279005299 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 176279005300 putative NAD(P) binding site [chemical binding]; other site 176279005301 dimer interface [polypeptide binding]; other site 176279005302 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 176279005303 Prostaglandin dehydrogenases; Region: PGDH; cd05288 176279005304 NAD(P) binding site [chemical binding]; other site 176279005305 substrate binding site [chemical binding]; other site 176279005306 dimer interface [polypeptide binding]; other site 176279005307 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 176279005308 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 176279005309 beta-galactosidase; Region: BGL; TIGR03356 176279005310 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 176279005311 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 176279005312 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 176279005313 active site 176279005314 P-loop; other site 176279005315 phosphorylation site [posttranslational modification] 176279005316 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 176279005317 methionine cluster; other site 176279005318 active site 176279005319 phosphorylation site [posttranslational modification] 176279005320 metal binding site [ion binding]; metal-binding site 176279005321 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 176279005322 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 176279005323 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 176279005324 putative substrate binding site [chemical binding]; other site 176279005325 putative ATP binding site [chemical binding]; other site 176279005326 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 176279005327 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 176279005328 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 176279005329 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 176279005330 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 176279005331 NAD-dependent deacetylase; Provisional; Region: PRK00481 176279005332 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 176279005333 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 176279005334 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 176279005335 23S rRNA interface [nucleotide binding]; other site 176279005336 L3 interface [polypeptide binding]; other site 176279005337 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 176279005338 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 176279005339 dimerization interface 3.5A [polypeptide binding]; other site 176279005340 active site 176279005341 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 176279005342 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 176279005343 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 176279005344 Walker A/P-loop; other site 176279005345 ATP binding site [chemical binding]; other site 176279005346 Q-loop/lid; other site 176279005347 ABC transporter signature motif; other site 176279005348 Walker B; other site 176279005349 D-loop; other site 176279005350 H-loop/switch region; other site 176279005351 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 176279005352 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 176279005353 Walker A/P-loop; other site 176279005354 ATP binding site [chemical binding]; other site 176279005355 Q-loop/lid; other site 176279005356 ABC transporter signature motif; other site 176279005357 Walker B; other site 176279005358 D-loop; other site 176279005359 H-loop/switch region; other site 176279005360 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 176279005361 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 176279005362 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 176279005363 alphaNTD homodimer interface [polypeptide binding]; other site 176279005364 alphaNTD - beta interaction site [polypeptide binding]; other site 176279005365 alphaNTD - beta' interaction site [polypeptide binding]; other site 176279005366 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 176279005367 30S ribosomal protein S11; Validated; Region: PRK05309 176279005368 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 176279005369 30S ribosomal protein S13; Region: bact_S13; TIGR03631 176279005370 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 176279005371 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 176279005372 rRNA binding site [nucleotide binding]; other site 176279005373 predicted 30S ribosome binding site; other site 176279005374 adenylate kinase; Reviewed; Region: adk; PRK00279 176279005375 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 176279005376 AMP-binding site [chemical binding]; other site 176279005377 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 176279005378 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 176279005379 SecY translocase; Region: SecY; pfam00344 176279005380 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 176279005381 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 176279005382 23S rRNA binding site [nucleotide binding]; other site 176279005383 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 176279005384 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 176279005385 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 176279005386 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 176279005387 5S rRNA interface [nucleotide binding]; other site 176279005388 L27 interface [polypeptide binding]; other site 176279005389 23S rRNA interface [nucleotide binding]; other site 176279005390 L5 interface [polypeptide binding]; other site 176279005391 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 176279005392 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 176279005393 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 176279005394 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 176279005395 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 176279005396 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 176279005397 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 176279005398 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 176279005399 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 176279005400 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 176279005401 RNA binding site [nucleotide binding]; other site 176279005402 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 176279005403 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 176279005404 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 176279005405 23S rRNA interface [nucleotide binding]; other site 176279005406 putative translocon interaction site; other site 176279005407 signal recognition particle (SRP54) interaction site; other site 176279005408 L23 interface [polypeptide binding]; other site 176279005409 trigger factor interaction site; other site 176279005410 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 176279005411 23S rRNA interface [nucleotide binding]; other site 176279005412 5S rRNA interface [nucleotide binding]; other site 176279005413 putative antibiotic binding site [chemical binding]; other site 176279005414 L25 interface [polypeptide binding]; other site 176279005415 L27 interface [polypeptide binding]; other site 176279005416 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 176279005417 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 176279005418 G-X-X-G motif; other site 176279005419 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 176279005420 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 176279005421 putative translocon binding site; other site 176279005422 protein-rRNA interface [nucleotide binding]; other site 176279005423 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 176279005424 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 176279005425 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 176279005426 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 176279005427 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 176279005428 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 176279005429 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 176279005430 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 176279005431 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 176279005432 DNA topoisomerase III; Provisional; Region: PRK07726 176279005433 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 176279005434 active site 176279005435 putative interdomain interaction site [polypeptide binding]; other site 176279005436 putative metal-binding site [ion binding]; other site 176279005437 putative nucleotide binding site [chemical binding]; other site 176279005438 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 176279005439 domain I; other site 176279005440 DNA binding groove [nucleotide binding] 176279005441 phosphate binding site [ion binding]; other site 176279005442 domain II; other site 176279005443 domain III; other site 176279005444 nucleotide binding site [chemical binding]; other site 176279005445 catalytic site [active] 176279005446 domain IV; other site 176279005447 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 176279005448 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 176279005449 Sugar transport protein; Region: Sugar_transport; pfam06800 176279005450 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 176279005451 glucose-1-dehydrogenase; Provisional; Region: PRK08936 176279005452 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 176279005453 NAD binding site [chemical binding]; other site 176279005454 homodimer interface [polypeptide binding]; other site 176279005455 active site 176279005456 Predicted permeases [General function prediction only]; Region: COG0679 176279005457 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 176279005458 Protein export membrane protein; Region: SecD_SecF; cl14618 176279005459 Protein export membrane protein; Region: SecD_SecF; cl14618 176279005460 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 176279005461 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 176279005462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 176279005463 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 176279005464 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176279005465 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 176279005466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279005468 putative substrate translocation pore; other site 176279005469 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176279005470 Transcriptional regulators [Transcription]; Region: MarR; COG1846 176279005471 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 176279005472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279005473 FeS/SAM binding site; other site 176279005474 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 176279005475 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 176279005476 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 176279005477 GTP binding site; other site 176279005478 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 176279005479 MoaE interaction surface [polypeptide binding]; other site 176279005480 MoeB interaction surface [polypeptide binding]; other site 176279005481 thiocarboxylated glycine; other site 176279005482 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 176279005483 MoaE homodimer interface [polypeptide binding]; other site 176279005484 MoaD interaction [polypeptide binding]; other site 176279005485 active site residues [active] 176279005486 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 176279005487 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 176279005488 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 176279005489 dimer interface [polypeptide binding]; other site 176279005490 putative functional site; other site 176279005491 putative MPT binding site; other site 176279005492 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 176279005493 trimer interface [polypeptide binding]; other site 176279005494 dimer interface [polypeptide binding]; other site 176279005495 putative active site [active] 176279005496 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 176279005497 MPT binding site; other site 176279005498 trimer interface [polypeptide binding]; other site 176279005499 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 176279005500 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 176279005501 ATP binding site [chemical binding]; other site 176279005502 substrate interface [chemical binding]; other site 176279005503 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 176279005504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279005505 Walker A/P-loop; other site 176279005506 ATP binding site [chemical binding]; other site 176279005507 Q-loop/lid; other site 176279005508 ABC transporter signature motif; other site 176279005509 Walker B; other site 176279005510 D-loop; other site 176279005511 H-loop/switch region; other site 176279005512 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 176279005513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279005514 dimer interface [polypeptide binding]; other site 176279005515 conserved gate region; other site 176279005516 putative PBP binding loops; other site 176279005517 ABC-ATPase subunit interface; other site 176279005518 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 176279005519 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 176279005520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279005521 Coenzyme A binding pocket [chemical binding]; other site 176279005522 BioY family; Region: BioY; pfam02632 176279005523 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 176279005524 active site 176279005525 dimerization interface [polypeptide binding]; other site 176279005526 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 176279005527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 176279005528 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 176279005529 urea transporter, Yersinia type; Region: urea_trans_yut; TIGR03441 176279005530 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 176279005531 alpha-gamma subunit interface [polypeptide binding]; other site 176279005532 beta-gamma subunit interface [polypeptide binding]; other site 176279005533 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 176279005534 gamma-beta subunit interface [polypeptide binding]; other site 176279005535 alpha-beta subunit interface [polypeptide binding]; other site 176279005536 urease subunit alpha; Reviewed; Region: ureC; PRK13207 176279005537 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 176279005538 subunit interactions [polypeptide binding]; other site 176279005539 active site 176279005540 flap region; other site 176279005541 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 176279005542 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 176279005543 dimer interface [polypeptide binding]; other site 176279005544 catalytic residues [active] 176279005545 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 176279005546 UreF; Region: UreF; pfam01730 176279005547 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 176279005548 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 176279005549 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176279005550 MarR family; Region: MarR_2; cl17246 176279005551 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 176279005552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176279005553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 176279005554 Surface antigen [General function prediction only]; Region: COG3942 176279005555 CHAP domain; Region: CHAP; pfam05257 176279005556 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 176279005557 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 176279005558 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 176279005559 Tic20-like protein; Region: Tic20; pfam09685 176279005560 Surface antigen [General function prediction only]; Region: COG3942 176279005561 CHAP domain; Region: CHAP; pfam05257 176279005562 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 176279005563 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 176279005564 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 176279005565 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 176279005566 putative ligand binding site [chemical binding]; other site 176279005567 putative NAD binding site [chemical binding]; other site 176279005568 catalytic site [active] 176279005569 hypothetical protein; Provisional; Region: PRK06753 176279005570 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 176279005571 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 176279005572 Lysozyme subfamily 2; Region: LYZ2; smart00047 176279005573 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 176279005574 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 176279005575 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 176279005576 active site 176279005577 Predicted transcriptional regulator [Transcription]; Region: COG2378 176279005578 HTH domain; Region: HTH_11; pfam08279 176279005579 CAAX protease self-immunity; Region: Abi; pfam02517 176279005580 Uncharacterized conserved protein [Function unknown]; Region: COG3589 176279005581 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 176279005582 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 176279005583 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 176279005584 putative active site [active] 176279005585 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176279005586 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 176279005587 active site turn [active] 176279005588 phosphorylation site [posttranslational modification] 176279005589 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176279005590 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 176279005591 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 176279005592 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 176279005593 putative active site [active] 176279005594 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 176279005595 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 176279005596 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 176279005597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279005598 motif II; other site 176279005599 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 176279005600 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176279005601 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176279005602 active site turn [active] 176279005603 phosphorylation site [posttranslational modification] 176279005604 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 176279005605 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 176279005606 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 176279005607 putative active site [active] 176279005608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 176279005609 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 176279005610 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 176279005611 putative hydrophobic ligand binding site [chemical binding]; other site 176279005612 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 176279005613 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 176279005614 oxidoreductase; Provisional; Region: PRK07985 176279005615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176279005616 NAD(P) binding site [chemical binding]; other site 176279005617 active site 176279005618 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176279005619 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 176279005620 metal binding site [ion binding]; metal-binding site 176279005621 dimer interface [polypeptide binding]; other site 176279005622 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 176279005623 putative active site [active] 176279005624 putative metal binding site [ion binding]; other site 176279005625 CAAX protease self-immunity; Region: Abi; pfam02517 176279005626 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 176279005627 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176279005628 active site 176279005629 dimer interface [polypeptide binding]; other site 176279005630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 176279005631 MOSC domain; Region: MOSC; pfam03473 176279005632 3-alpha domain; Region: 3-alpha; pfam03475 176279005633 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 176279005634 active site 176279005635 catalytic residues [active] 176279005636 ribulokinase; Provisional; Region: PRK04123 176279005637 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 176279005638 N- and C-terminal domain interface [polypeptide binding]; other site 176279005639 active site 176279005640 MgATP binding site [chemical binding]; other site 176279005641 catalytic site [active] 176279005642 metal binding site [ion binding]; metal-binding site 176279005643 carbohydrate binding site [chemical binding]; other site 176279005644 homodimer interface [polypeptide binding]; other site 176279005645 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 176279005646 active site 176279005647 DNA binding site [nucleotide binding] 176279005648 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 176279005649 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 176279005650 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 176279005651 Predicted transcriptional regulators [Transcription]; Region: COG1695 176279005652 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 176279005653 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 176279005654 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 176279005655 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 176279005656 homotetramer interface [polypeptide binding]; other site 176279005657 FMN binding site [chemical binding]; other site 176279005658 homodimer contacts [polypeptide binding]; other site 176279005659 putative active site [active] 176279005660 putative substrate binding site [chemical binding]; other site 176279005661 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 176279005662 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 176279005663 oligomer interface [polypeptide binding]; other site 176279005664 metal binding site [ion binding]; metal-binding site 176279005665 metal binding site [ion binding]; metal-binding site 176279005666 putative Cl binding site [ion binding]; other site 176279005667 aspartate ring; other site 176279005668 hydrophobic gate; other site 176279005669 periplasmic entrance; other site 176279005670 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 176279005671 active site 176279005672 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 176279005673 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 176279005674 Osteopontin; Region: Osteopontin; cl02425 176279005675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005676 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 176279005677 putative substrate translocation pore; other site 176279005678 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 176279005679 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 176279005680 HlyD family secretion protein; Region: HlyD_3; pfam13437 176279005681 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 176279005682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176279005683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005684 putative substrate translocation pore; other site 176279005685 Predicted membrane protein [Function unknown]; Region: COG4640 176279005686 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 176279005687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176279005688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176279005689 putative DNA binding site [nucleotide binding]; other site 176279005690 putative Zn2+ binding site [ion binding]; other site 176279005691 Uncharacterized conserved protein [Function unknown]; Region: COG1434 176279005692 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 176279005693 putative active site [active] 176279005694 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176279005695 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176279005696 Walker A/P-loop; other site 176279005697 ATP binding site [chemical binding]; other site 176279005698 Q-loop/lid; other site 176279005699 ABC transporter signature motif; other site 176279005700 Walker B; other site 176279005701 D-loop; other site 176279005702 H-loop/switch region; other site 176279005703 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 176279005704 FtsX-like permease family; Region: FtsX; pfam02687 176279005705 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176279005706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279005707 active site 176279005708 phosphorylation site [posttranslational modification] 176279005709 intermolecular recognition site; other site 176279005710 dimerization interface [polypeptide binding]; other site 176279005711 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176279005712 DNA binding site [nucleotide binding] 176279005713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176279005714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 176279005715 dimerization interface [polypeptide binding]; other site 176279005716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279005717 ATP binding site [chemical binding]; other site 176279005718 Mg2+ binding site [ion binding]; other site 176279005719 G-X-G motif; other site 176279005720 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 176279005721 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 176279005722 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176279005723 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 176279005724 putative ADP-binding pocket [chemical binding]; other site 176279005725 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 176279005726 L-lactate permease; Region: Lactate_perm; cl00701 176279005727 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176279005728 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 176279005729 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 176279005730 active site 176279005731 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176279005732 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 176279005733 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 176279005734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279005735 Coenzyme A binding pocket [chemical binding]; other site 176279005736 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 176279005737 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 176279005738 putative NADP binding site [chemical binding]; other site 176279005739 putative dimer interface [polypeptide binding]; other site 176279005740 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 176279005741 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 176279005742 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 176279005743 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 176279005744 Cl binding site [ion binding]; other site 176279005745 oligomer interface [polypeptide binding]; other site 176279005746 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 176279005747 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176279005748 active site turn [active] 176279005749 phosphorylation site [posttranslational modification] 176279005750 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176279005751 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 176279005752 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176279005753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 176279005754 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 176279005755 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 176279005756 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 176279005757 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 176279005758 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 176279005759 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 176279005760 dimer interface [polypeptide binding]; other site 176279005761 FMN binding site [chemical binding]; other site 176279005762 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176279005763 MarR family; Region: MarR_2; pfam12802 176279005764 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 176279005765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005766 putative substrate translocation pore; other site 176279005767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 176279005768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279005769 active site 176279005770 phosphorylation site [posttranslational modification] 176279005771 intermolecular recognition site; other site 176279005772 dimerization interface [polypeptide binding]; other site 176279005773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 176279005774 DNA binding residues [nucleotide binding] 176279005775 dimerization interface [polypeptide binding]; other site 176279005776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 176279005777 Histidine kinase; Region: HisKA_3; pfam07730 176279005778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279005779 ATP binding site [chemical binding]; other site 176279005780 Mg2+ binding site [ion binding]; other site 176279005781 G-X-G motif; other site 176279005782 GAF domain; Region: GAF; cl17456 176279005783 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 176279005784 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 176279005785 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 176279005786 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 176279005787 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 176279005788 [4Fe-4S] binding site [ion binding]; other site 176279005789 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 176279005790 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 176279005791 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 176279005792 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 176279005793 molybdopterin cofactor binding site; other site 176279005794 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 176279005795 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 176279005796 active site 176279005797 SAM binding site [chemical binding]; other site 176279005798 homodimer interface [polypeptide binding]; other site 176279005799 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 176279005800 [2Fe-2S] cluster binding site [ion binding]; other site 176279005801 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 176279005802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176279005803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279005804 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 176279005805 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 176279005806 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 176279005807 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 176279005808 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 176279005809 putative active site [active] 176279005810 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 176279005811 active site 176279005812 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 176279005813 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 176279005814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279005815 Coenzyme A binding pocket [chemical binding]; other site 176279005816 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 176279005817 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 176279005818 putative hydrophobic ligand binding site [chemical binding]; other site 176279005819 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 176279005820 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 176279005821 catalytic residues [active] 176279005822 FemAB family; Region: FemAB; pfam02388 176279005823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 176279005824 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: vorA; PRK08366 176279005825 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 176279005826 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 176279005827 Walker A/P-loop; other site 176279005828 ATP binding site [chemical binding]; other site 176279005829 Q-loop/lid; other site 176279005830 ABC transporter signature motif; other site 176279005831 Walker B; other site 176279005832 D-loop; other site 176279005833 H-loop/switch region; other site 176279005834 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 176279005835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279005836 dimer interface [polypeptide binding]; other site 176279005837 conserved gate region; other site 176279005838 putative PBP binding loops; other site 176279005839 ABC-ATPase subunit interface; other site 176279005840 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 176279005841 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 176279005842 substrate binding pocket [chemical binding]; other site 176279005843 membrane-bound complex binding site; other site 176279005844 hinge residues; other site 176279005845 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 176279005846 catalytic core [active] 176279005847 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 176279005848 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 176279005849 Cation efflux family; Region: Cation_efflux; pfam01545 176279005850 Predicted membrane protein [Function unknown]; Region: COG2246 176279005851 GtrA-like protein; Region: GtrA; pfam04138 176279005852 Transposase, Mutator family; Region: Transposase_mut; pfam00872 176279005853 MULE transposase domain; Region: MULE; pfam10551 176279005854 glycerate kinase; Region: TIGR00045 176279005855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005856 putative substrate translocation pore; other site 176279005857 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 176279005858 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 176279005859 putative phosphoesterase; Region: acc_ester; TIGR03729 176279005860 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 176279005861 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 176279005862 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 176279005863 Beta-lactamase; Region: Beta-lactamase; pfam00144 176279005864 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 176279005865 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 176279005866 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 176279005867 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 176279005868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279005870 putative substrate translocation pore; other site 176279005871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005872 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 176279005873 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 176279005874 GAF domain; Region: GAF_3; pfam13492 176279005875 Histidine kinase; Region: His_kinase; pfam06580 176279005876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279005877 Mg2+ binding site [ion binding]; other site 176279005878 G-X-G motif; other site 176279005879 two-component response regulator; Provisional; Region: PRK14084 176279005880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279005881 active site 176279005882 phosphorylation site [posttranslational modification] 176279005883 intermolecular recognition site; other site 176279005884 dimerization interface [polypeptide binding]; other site 176279005885 LytTr DNA-binding domain; Region: LytTR; pfam04397 176279005886 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 176279005887 antiholin-like protein LrgB; Provisional; Region: PRK04288 176279005888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279005889 dimer interface [polypeptide binding]; other site 176279005890 conserved gate region; other site 176279005891 ABC-ATPase subunit interface; other site 176279005892 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 176279005893 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 176279005894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279005895 dimer interface [polypeptide binding]; other site 176279005896 conserved gate region; other site 176279005897 putative PBP binding loops; other site 176279005898 ABC-ATPase subunit interface; other site 176279005899 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 176279005900 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 176279005901 Walker A/P-loop; other site 176279005902 ATP binding site [chemical binding]; other site 176279005903 Q-loop/lid; other site 176279005904 ABC transporter signature motif; other site 176279005905 Walker B; other site 176279005906 D-loop; other site 176279005907 H-loop/switch region; other site 176279005908 FOG: CBS domain [General function prediction only]; Region: COG0517 176279005909 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 176279005910 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 176279005911 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 176279005912 putative NAD(P) binding site [chemical binding]; other site 176279005913 catalytic Zn binding site [ion binding]; other site 176279005914 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 176279005915 amino acid transporter; Region: 2A0306; TIGR00909 176279005916 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 176279005917 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 176279005918 substrate binding pocket [chemical binding]; other site 176279005919 catalytic triad [active] 176279005920 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 176279005921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279005922 putative substrate translocation pore; other site 176279005923 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 176279005924 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 176279005925 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176279005926 Walker A/P-loop; other site 176279005927 ATP binding site [chemical binding]; other site 176279005928 Q-loop/lid; other site 176279005929 ABC transporter signature motif; other site 176279005930 Walker B; other site 176279005931 D-loop; other site 176279005932 H-loop/switch region; other site 176279005933 CAAX protease self-immunity; Region: Abi; pfam02517 176279005934 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 176279005935 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 176279005936 active site 176279005937 FMN binding site [chemical binding]; other site 176279005938 substrate binding site [chemical binding]; other site 176279005939 3Fe-4S cluster binding site [ion binding]; other site 176279005940 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 176279005941 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 176279005942 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 176279005943 oligomer interface [polypeptide binding]; other site 176279005944 active site 176279005945 metal binding site [ion binding]; metal-binding site 176279005946 short chain dehydrogenase; Validated; Region: PRK08589 176279005947 classical (c) SDRs; Region: SDR_c; cd05233 176279005948 NAD(P) binding site [chemical binding]; other site 176279005949 active site 176279005950 exopolyphosphatase; Region: exo_poly_only; TIGR03706 176279005951 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 176279005952 nucleotide binding site [chemical binding]; other site 176279005953 polyphosphate kinase; Provisional; Region: PRK05443 176279005954 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 176279005955 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 176279005956 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 176279005957 putative domain interface [polypeptide binding]; other site 176279005958 putative active site [active] 176279005959 catalytic site [active] 176279005960 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 176279005961 putative domain interface [polypeptide binding]; other site 176279005962 putative active site [active] 176279005963 catalytic site [active] 176279005964 acetylornithine deacetylase; Validated; Region: PRK08596 176279005965 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 176279005966 metal binding site [ion binding]; metal-binding site 176279005967 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 176279005968 classical (c) SDRs; Region: SDR_c; cd05233 176279005969 NAD(P) binding site [chemical binding]; other site 176279005970 active site 176279005971 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 176279005972 PLD-like domain; Region: PLDc_2; pfam13091 176279005973 putative homodimer interface [polypeptide binding]; other site 176279005974 putative active site [active] 176279005975 catalytic site [active] 176279005976 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 176279005977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176279005978 ATP binding site [chemical binding]; other site 176279005979 putative Mg++ binding site [ion binding]; other site 176279005980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279005981 nucleotide binding region [chemical binding]; other site 176279005982 ATP-binding site [chemical binding]; other site 176279005983 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 176279005984 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 176279005985 active site 176279005986 8-oxo-dGMP binding site [chemical binding]; other site 176279005987 nudix motif; other site 176279005988 metal binding site [ion binding]; metal-binding site 176279005989 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 176279005990 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 176279005991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176279005992 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 176279005993 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 176279005994 active site 176279005995 substrate binding site [chemical binding]; other site 176279005996 metal binding site [ion binding]; metal-binding site 176279005997 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 176279005998 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 176279005999 active site 176279006000 tetramer interface; other site 176279006001 fructuronate transporter; Provisional; Region: PRK10034; cl15264 176279006002 gluconate transporter; Region: gntP; TIGR00791 176279006003 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 176279006004 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 176279006005 N- and C-terminal domain interface [polypeptide binding]; other site 176279006006 active site 176279006007 catalytic site [active] 176279006008 metal binding site [ion binding]; metal-binding site 176279006009 carbohydrate binding site [chemical binding]; other site 176279006010 ATP binding site [chemical binding]; other site 176279006011 Transcriptional regulators [Transcription]; Region: GntR; COG1802 176279006012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 176279006013 DNA-binding site [nucleotide binding]; DNA binding site 176279006014 FCD domain; Region: FCD; pfam07729 176279006015 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 176279006016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006017 putative substrate translocation pore; other site 176279006018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006019 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 176279006020 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 176279006021 DNA binding residues [nucleotide binding] 176279006022 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 176279006023 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 176279006024 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 176279006025 active site 176279006026 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 176279006027 synthetase active site [active] 176279006028 NTP binding site [chemical binding]; other site 176279006029 metal binding site [ion binding]; metal-binding site 176279006030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 176279006031 Predicted membrane protein [Function unknown]; Region: COG1289 176279006032 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 176279006033 Uncharacterized conserved protein [Function unknown]; Region: COG1359 176279006034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006035 D-galactonate transporter; Region: 2A0114; TIGR00893 176279006036 putative substrate translocation pore; other site 176279006037 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 176279006038 active site 176279006039 pyrophosphate binding site [ion binding]; other site 176279006040 thiamine phosphate binding site [chemical binding]; other site 176279006041 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 176279006042 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 176279006043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176279006044 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 176279006045 thiS-thiF/thiG interaction site; other site 176279006046 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 176279006047 ThiS interaction site; other site 176279006048 putative active site [active] 176279006049 tetramer interface [polypeptide binding]; other site 176279006050 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 176279006051 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 176279006052 ATP binding site [chemical binding]; other site 176279006053 substrate interface [chemical binding]; other site 176279006054 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 176279006055 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 176279006056 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 176279006057 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 176279006058 Uncharacterized membrane protein [Function unknown]; Region: COG3949 176279006059 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 176279006060 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 176279006061 NAD binding site [chemical binding]; other site 176279006062 catalytic residues [active] 176279006063 substrate binding site [chemical binding]; other site 176279006064 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 176279006065 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 176279006066 metal binding site [ion binding]; metal-binding site 176279006067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279006068 Coenzyme A binding pocket [chemical binding]; other site 176279006069 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 176279006070 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 176279006071 putative metal binding site [ion binding]; other site 176279006072 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 176279006073 active site 176279006074 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 176279006075 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 176279006076 NAD(P) binding site [chemical binding]; other site 176279006077 catalytic residues [active] 176279006078 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 176279006079 dimer interface [polypeptide binding]; other site 176279006080 FMN binding site [chemical binding]; other site 176279006081 D-lactate dehydrogenase; Provisional; Region: PRK12480 176279006082 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 176279006083 homodimer interface [polypeptide binding]; other site 176279006084 ligand binding site [chemical binding]; other site 176279006085 NAD binding site [chemical binding]; other site 176279006086 catalytic site [active] 176279006087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279006088 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 176279006089 active site 176279006090 motif I; other site 176279006091 motif II; other site 176279006092 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 176279006093 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 176279006094 active site 176279006095 catalytic site [active] 176279006096 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 176279006097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279006098 Coenzyme A binding pocket [chemical binding]; other site 176279006099 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 176279006100 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 176279006101 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 176279006102 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 176279006103 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 176279006104 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 176279006105 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 176279006106 N- and C-terminal domain interface [polypeptide binding]; other site 176279006107 D-xylulose kinase; Region: XylB; TIGR01312 176279006108 active site 176279006109 MgATP binding site [chemical binding]; other site 176279006110 catalytic site [active] 176279006111 metal binding site [ion binding]; metal-binding site 176279006112 xylulose binding site [chemical binding]; other site 176279006113 homodimer interface [polypeptide binding]; other site 176279006114 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 176279006115 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 176279006116 substrate binding site [chemical binding]; other site 176279006117 dimer interface [polypeptide binding]; other site 176279006118 ATP binding site [chemical binding]; other site 176279006119 D-ribose pyranase; Provisional; Region: PRK11797 176279006120 Sugar transport protein; Region: Sugar_transport; pfam06800 176279006121 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 176279006122 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 176279006123 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 176279006124 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 176279006125 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 176279006126 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 176279006127 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 176279006128 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 176279006129 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 176279006130 nucleophilic elbow; other site 176279006131 catalytic triad; other site 176279006132 Uncharacterized conserved protein [Function unknown]; Region: COG1284 176279006133 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 176279006134 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 176279006135 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 176279006136 catalytic residues [active] 176279006137 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 176279006138 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 176279006139 catalytic Zn binding site [ion binding]; other site 176279006140 structural Zn binding site [ion binding]; other site 176279006141 NAD(P) binding site [chemical binding]; other site 176279006142 CAAX protease self-immunity; Region: Abi; pfam02517 176279006143 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 176279006144 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 176279006145 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 176279006146 active site turn [active] 176279006147 phosphorylation site [posttranslational modification] 176279006148 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 176279006149 HPr interaction site; other site 176279006150 glycerol kinase (GK) interaction site [polypeptide binding]; other site 176279006151 active site 176279006152 phosphorylation site [posttranslational modification] 176279006153 pyruvate oxidase; Provisional; Region: PRK08611 176279006154 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 176279006155 PYR/PP interface [polypeptide binding]; other site 176279006156 dimer interface [polypeptide binding]; other site 176279006157 tetramer interface [polypeptide binding]; other site 176279006158 TPP binding site [chemical binding]; other site 176279006159 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 176279006160 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 176279006161 TPP-binding site [chemical binding]; other site 176279006162 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 176279006163 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 176279006164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176279006165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176279006166 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 176279006167 putative dimerization interface [polypeptide binding]; other site 176279006168 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 176279006169 Surface antigen [General function prediction only]; Region: COG3942 176279006170 CHAP domain; Region: CHAP; pfam05257 176279006171 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 176279006172 homodimer interface [polypeptide binding]; other site 176279006173 catalytic residues [active] 176279006174 NAD binding site [chemical binding]; other site 176279006175 substrate binding pocket [chemical binding]; other site 176279006176 flexible flap; other site 176279006177 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 176279006178 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 176279006179 dimer interface [polypeptide binding]; other site 176279006180 active site 176279006181 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 176279006182 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 176279006183 DNA binding site [nucleotide binding] 176279006184 active site 176279006185 Virus attachment protein p12 family; Region: P12; pfam12669 176279006186 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 176279006187 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 176279006188 G1 box; other site 176279006189 GTP/Mg2+ binding site [chemical binding]; other site 176279006190 Switch I region; other site 176279006191 G2 box; other site 176279006192 G3 box; other site 176279006193 Switch II region; other site 176279006194 G4 box; other site 176279006195 G5 box; other site 176279006196 Nucleoside recognition; Region: Gate; pfam07670 176279006197 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 176279006198 Nucleoside recognition; Region: Gate; pfam07670 176279006199 FeoA domain; Region: FeoA; cl00838 176279006200 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 176279006201 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 176279006202 Glutamate binding site [chemical binding]; other site 176279006203 homodimer interface [polypeptide binding]; other site 176279006204 NAD binding site [chemical binding]; other site 176279006205 catalytic residues [active] 176279006206 short chain dehydrogenase; Provisional; Region: PRK06701 176279006207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176279006208 NAD(P) binding site [chemical binding]; other site 176279006209 active site 176279006210 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 176279006211 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 176279006212 metal-binding site [ion binding] 176279006213 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 176279006214 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 176279006215 metal-binding site [ion binding] 176279006216 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 176279006217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 176279006218 motif II; other site 176279006219 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 176279006220 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 176279006221 metal-binding site [ion binding] 176279006222 D-lactate dehydrogenase; Validated; Region: PRK08605 176279006223 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 176279006224 homodimer interface [polypeptide binding]; other site 176279006225 ligand binding site [chemical binding]; other site 176279006226 NAD binding site [chemical binding]; other site 176279006227 catalytic site [active] 176279006228 transaminase; Reviewed; Region: PRK08068 176279006229 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 176279006230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279006231 homodimer interface [polypeptide binding]; other site 176279006232 catalytic residue [active] 176279006233 Surface antigen [General function prediction only]; Region: COG3942 176279006234 CHAP domain; Region: CHAP; pfam05257 176279006235 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 176279006236 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 176279006237 catalytic triad [active] 176279006238 catalytic triad [active] 176279006239 oxyanion hole [active] 176279006240 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 176279006241 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 176279006242 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 176279006243 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 176279006244 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 176279006245 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 176279006246 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 176279006247 Phosphotransferase enzyme family; Region: APH; pfam01636 176279006248 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 176279006249 active site 176279006250 ATP binding site [chemical binding]; other site 176279006251 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 176279006252 active site 176279006253 ATP binding site [chemical binding]; other site 176279006254 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 176279006255 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 176279006256 quinone interaction residues [chemical binding]; other site 176279006257 active site 176279006258 catalytic residues [active] 176279006259 FMN binding site [chemical binding]; other site 176279006260 substrate binding site [chemical binding]; other site 176279006261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 176279006262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 176279006263 Predicted membrane protein [Function unknown]; Region: COG4640 176279006264 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 176279006265 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 176279006266 Double zinc ribbon; Region: DZR; pfam12773 176279006267 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 176279006268 tetramerization interface [polypeptide binding]; other site 176279006269 active site 176279006270 Pantoate-beta-alanine ligase; Region: PanC; cd00560 176279006271 pantoate--beta-alanine ligase; Region: panC; TIGR00018 176279006272 active site 176279006273 ATP-binding site [chemical binding]; other site 176279006274 pantoate-binding site; other site 176279006275 HXXH motif; other site 176279006276 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 176279006277 oligomerization interface [polypeptide binding]; other site 176279006278 active site 176279006279 metal binding site [ion binding]; metal-binding site 176279006280 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 176279006281 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 176279006282 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 176279006283 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 176279006284 acetolactate synthase; Reviewed; Region: PRK08617 176279006285 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 176279006286 PYR/PP interface [polypeptide binding]; other site 176279006287 dimer interface [polypeptide binding]; other site 176279006288 TPP binding site [chemical binding]; other site 176279006289 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 176279006290 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 176279006291 TPP-binding site [chemical binding]; other site 176279006292 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 176279006293 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 176279006294 dimer interface [polypeptide binding]; other site 176279006295 tetramer (dimer of dimers) interface [polypeptide binding]; other site 176279006296 NAD binding site [chemical binding]; other site 176279006297 substrate binding site [chemical binding]; other site 176279006298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176279006299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176279006300 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 176279006301 putative dimerization interface [polypeptide binding]; other site 176279006302 amino acid transporter; Region: 2A0306; TIGR00909 176279006303 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 176279006304 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176279006305 inhibitor-cofactor binding pocket; inhibition site 176279006306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279006307 catalytic residue [active] 176279006308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 176279006309 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 176279006310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279006311 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176279006312 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 176279006313 catalytic residue [active] 176279006314 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 176279006315 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 176279006316 PEP synthetase regulatory protein; Provisional; Region: PRK05339 176279006317 pyruvate phosphate dikinase; Provisional; Region: PRK09279 176279006318 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 176279006319 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 176279006320 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 176279006321 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 176279006322 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 176279006323 acyl-activating enzyme (AAE) consensus motif; other site 176279006324 AMP binding site [chemical binding]; other site 176279006325 active site 176279006326 CoA binding site [chemical binding]; other site 176279006327 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 176279006328 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 176279006329 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 176279006330 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 176279006331 metal binding site [ion binding]; metal-binding site 176279006332 dimer interface [polypeptide binding]; other site 176279006333 choline dehydrogenase; Validated; Region: PRK02106 176279006334 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 176279006335 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 176279006336 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 176279006337 tetramerization interface [polypeptide binding]; other site 176279006338 NAD(P) binding site [chemical binding]; other site 176279006339 catalytic residues [active] 176279006340 Predicted transcriptional regulators [Transcription]; Region: COG1510 176279006341 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 176279006342 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 176279006343 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 176279006344 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 176279006345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279006346 FeS/SAM binding site; other site 176279006347 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 176279006348 Class III ribonucleotide reductase; Region: RNR_III; cd01675 176279006349 effector binding site; other site 176279006350 active site 176279006351 Zn binding site [ion binding]; other site 176279006352 glycine loop; other site 176279006353 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 176279006354 ligand-binding site [chemical binding]; other site 176279006355 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 176279006356 ATP-sulfurylase; Region: ATPS; cd00517 176279006357 active site 176279006358 HXXH motif; other site 176279006359 flexible loop; other site 176279006360 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 176279006361 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 176279006362 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 176279006363 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 176279006364 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 176279006365 active site 176279006366 SAM binding site [chemical binding]; other site 176279006367 homodimer interface [polypeptide binding]; other site 176279006368 sulfite reductase subunit beta; Provisional; Region: PRK13504 176279006369 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 176279006370 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 176279006371 Protein of unknown function (DUF1636); Region: DUF1636; cl17843 176279006372 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 176279006373 Flavodoxin; Region: Flavodoxin_1; pfam00258 176279006374 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 176279006375 FAD binding pocket [chemical binding]; other site 176279006376 FAD binding motif [chemical binding]; other site 176279006377 catalytic residues [active] 176279006378 NAD binding pocket [chemical binding]; other site 176279006379 phosphate binding motif [ion binding]; other site 176279006380 beta-alpha-beta structure motif; other site 176279006381 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 176279006382 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 176279006383 Active Sites [active] 176279006384 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 176279006385 catalytic residues [active] 176279006386 dimer interface [polypeptide binding]; other site 176279006387 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 176279006388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279006389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176279006390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176279006391 MarR family; Region: MarR; pfam01047 176279006392 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 176279006393 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 176279006394 Double zinc ribbon; Region: DZR; pfam12773 176279006395 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 176279006396 putative transporter; Provisional; Region: PRK10484 176279006397 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 176279006398 Na binding site [ion binding]; other site 176279006399 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 176279006400 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176279006401 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 176279006402 Walker A/P-loop; other site 176279006403 ATP binding site [chemical binding]; other site 176279006404 Q-loop/lid; other site 176279006405 ABC transporter signature motif; other site 176279006406 Walker B; other site 176279006407 D-loop; other site 176279006408 H-loop/switch region; other site 176279006409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 176279006410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279006411 ATP binding site [chemical binding]; other site 176279006412 Mg2+ binding site [ion binding]; other site 176279006413 G-X-G motif; other site 176279006414 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176279006415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279006416 active site 176279006417 phosphorylation site [posttranslational modification] 176279006418 intermolecular recognition site; other site 176279006419 dimerization interface [polypeptide binding]; other site 176279006420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176279006421 DNA binding site [nucleotide binding] 176279006422 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 176279006423 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 176279006424 dimer interface [polypeptide binding]; other site 176279006425 active site 176279006426 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 176279006427 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 176279006428 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 176279006429 putative NAD(P) binding site [chemical binding]; other site 176279006430 putative active site [active] 176279006431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 176279006432 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 176279006433 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 176279006434 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 176279006435 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 176279006436 Protein of unknown function (DUF867); Region: DUF867; pfam05908 176279006437 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 176279006438 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 176279006439 substrate binding site [chemical binding]; other site 176279006440 ATP binding site [chemical binding]; other site 176279006441 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 176279006442 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 176279006443 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 176279006444 Ligand Binding Site [chemical binding]; other site 176279006445 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 176279006446 Cadmium resistance transporter; Region: Cad; pfam03596 176279006447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176279006448 putative DNA binding site [nucleotide binding]; other site 176279006449 putative Zn2+ binding site [ion binding]; other site 176279006450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176279006451 putative Zn2+ binding site [ion binding]; other site 176279006452 putative DNA binding site [nucleotide binding]; other site 176279006453 Short C-terminal domain; Region: SHOCT; pfam09851 176279006454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006455 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279006456 putative substrate translocation pore; other site 176279006457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 176279006458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 176279006459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 176279006460 dimerization interface [polypeptide binding]; other site 176279006461 Transposase IS200 like; Region: Y1_Tnp; pfam01797 176279006462 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 176279006463 MarR family; Region: MarR_2; pfam12802 176279006464 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 176279006465 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 176279006466 dimer interface [polypeptide binding]; other site 176279006467 PYR/PP interface [polypeptide binding]; other site 176279006468 TPP binding site [chemical binding]; other site 176279006469 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 176279006470 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 176279006471 TPP-binding site [chemical binding]; other site 176279006472 dimer interface [polypeptide binding]; other site 176279006473 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 176279006474 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 176279006475 putative active site [active] 176279006476 putative metal binding site [ion binding]; other site 176279006477 Predicted esterase [General function prediction only]; Region: COG0627 176279006478 S-formylglutathione hydrolase; Region: PLN02442 176279006479 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 176279006480 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 176279006481 ligand binding site [chemical binding]; other site 176279006482 flexible hinge region; other site 176279006483 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 176279006484 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 176279006485 ornithine carbamoyltransferase; Validated; Region: PRK02102 176279006486 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 176279006487 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 176279006488 arginine deiminase; Provisional; Region: PRK01388 176279006489 Arginine repressor [Transcription]; Region: ArgR; COG1438 176279006490 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 176279006491 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 176279006492 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 176279006493 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 176279006494 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 176279006495 active site 176279006496 Zn binding site [ion binding]; other site 176279006497 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 176279006498 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 176279006499 metal binding site [ion binding]; metal-binding site 176279006500 dimer interface [polypeptide binding]; other site 176279006501 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 176279006502 acetoin reductase; Validated; Region: PRK08643 176279006503 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 176279006504 NAD binding site [chemical binding]; other site 176279006505 homotetramer interface [polypeptide binding]; other site 176279006506 homodimer interface [polypeptide binding]; other site 176279006507 active site 176279006508 substrate binding site [chemical binding]; other site 176279006509 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176279006510 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 176279006511 HTH domain; Region: HTH_11; pfam08279 176279006512 PRD domain; Region: PRD; pfam00874 176279006513 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 176279006514 active site 176279006515 P-loop; other site 176279006516 phosphorylation site [posttranslational modification] 176279006517 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 176279006518 active site 176279006519 phosphorylation site [posttranslational modification] 176279006520 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 176279006521 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 176279006522 active site 176279006523 P-loop; other site 176279006524 phosphorylation site [posttranslational modification] 176279006525 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 176279006526 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 176279006527 active site 176279006528 phosphorylation site [posttranslational modification] 176279006529 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 176279006530 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 176279006531 Predicted membrane protein [Function unknown]; Region: COG1511 176279006532 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 176279006533 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 176279006534 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 176279006535 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 176279006536 CHAP domain; Region: CHAP; pfam05257 176279006537 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 176279006538 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 176279006539 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 176279006540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006541 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279006542 putative substrate translocation pore; other site 176279006543 methionine sulfoxide reductase A; Provisional; Region: PRK05528 176279006544 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 176279006545 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 176279006546 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 176279006547 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 176279006548 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 176279006549 DEAD/DEAH box helicase; Region: DEAD; pfam00270 176279006550 ATP binding site [chemical binding]; other site 176279006551 putative Mg++ binding site [ion binding]; other site 176279006552 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 176279006553 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 176279006554 nucleotide binding region [chemical binding]; other site 176279006555 ATP-binding site [chemical binding]; other site 176279006556 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 176279006557 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 176279006558 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 176279006559 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 176279006560 SecY translocase; Region: SecY; pfam00344 176279006561 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 176279006562 legume lectins; Region: lectin_L-type; cd01951 176279006563 homotetramer interaction site [polypeptide binding]; other site 176279006564 carbohydrate binding site [chemical binding]; other site 176279006565 metal binding site [ion binding]; metal-binding site 176279006566 Putative Ig domain; Region: He_PIG; pfam05345 176279006567 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 176279006568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279006569 dimer interface [polypeptide binding]; other site 176279006570 conserved gate region; other site 176279006571 putative PBP binding loops; other site 176279006572 ABC-ATPase subunit interface; other site 176279006573 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 176279006574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279006575 dimer interface [polypeptide binding]; other site 176279006576 conserved gate region; other site 176279006577 ABC-ATPase subunit interface; other site 176279006578 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 176279006579 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 176279006580 Walker A/P-loop; other site 176279006581 ATP binding site [chemical binding]; other site 176279006582 Q-loop/lid; other site 176279006583 ABC transporter signature motif; other site 176279006584 Walker B; other site 176279006585 D-loop; other site 176279006586 H-loop/switch region; other site 176279006587 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 176279006588 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 176279006589 substrate binding pocket [chemical binding]; other site 176279006590 membrane-bound complex binding site; other site 176279006591 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 176279006592 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 176279006593 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 176279006594 active site 176279006595 metal binding site [ion binding]; metal-binding site 176279006596 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 176279006597 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 176279006598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006599 putative substrate translocation pore; other site 176279006600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 176279006601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176279006602 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 176279006603 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 176279006604 DXD motif; other site 176279006605 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 176279006606 Putative catalytic polysaccharide deacetylase domain of bacterial intercellular adhesion protein IcaB and similar proteins; Region: CE4_IcaB_5s; cd10965 176279006607 putative active site [active] 176279006608 putative metal binding site [ion binding]; other site 176279006609 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 176279006610 Acyltransferase family; Region: Acyl_transf_3; pfam01757 176279006611 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 176279006612 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 176279006613 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 176279006614 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 176279006615 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 176279006616 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 176279006617 metal binding site [ion binding]; metal-binding site 176279006618 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 176279006619 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 176279006620 substrate binding site [chemical binding]; other site 176279006621 glutamase interaction surface [polypeptide binding]; other site 176279006622 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 176279006623 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 176279006624 catalytic residues [active] 176279006625 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 176279006626 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 176279006627 putative active site [active] 176279006628 oxyanion strand; other site 176279006629 catalytic triad [active] 176279006630 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 176279006631 putative active site pocket [active] 176279006632 4-fold oligomerization interface [polypeptide binding]; other site 176279006633 metal binding residues [ion binding]; metal-binding site 176279006634 3-fold/trimer interface [polypeptide binding]; other site 176279006635 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 176279006636 histidinol dehydrogenase; Region: hisD; TIGR00069 176279006637 NAD binding site [chemical binding]; other site 176279006638 dimerization interface [polypeptide binding]; other site 176279006639 product binding site; other site 176279006640 substrate binding site [chemical binding]; other site 176279006641 zinc binding site [ion binding]; other site 176279006642 catalytic residues [active] 176279006643 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 176279006644 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 176279006645 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 176279006646 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 176279006647 Uncharacterized conserved protein [Function unknown]; Region: COG2128 176279006648 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 176279006649 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 176279006650 putative DNA binding site [nucleotide binding]; other site 176279006651 putative Zn2+ binding site [ion binding]; other site 176279006652 AsnC family; Region: AsnC_trans_reg; pfam01037 176279006653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 176279006654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 176279006655 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 176279006656 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 176279006657 Uncharacterized conserved protein [Function unknown]; Region: COG2353 176279006658 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 176279006659 Strictosidine synthase; Region: Str_synth; pfam03088 176279006660 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 176279006661 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 176279006662 active site residue [active] 176279006663 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 176279006664 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 176279006665 putative substrate binding pocket [chemical binding]; other site 176279006666 AC domain interface; other site 176279006667 catalytic triad [active] 176279006668 AB domain interface; other site 176279006669 interchain disulfide; other site 176279006670 BCCT family transporter; Region: BCCT; pfam02028 176279006671 iron-sulfur cluster-binding protein; Region: TIGR00273 176279006672 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 176279006673 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 176279006674 E3 interaction surface; other site 176279006675 lipoyl attachment site [posttranslational modification]; other site 176279006676 e3 binding domain; Region: E3_binding; pfam02817 176279006677 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 176279006678 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 176279006679 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 176279006680 alpha subunit interface [polypeptide binding]; other site 176279006681 TPP binding site [chemical binding]; other site 176279006682 heterodimer interface [polypeptide binding]; other site 176279006683 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 176279006684 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 176279006685 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 176279006686 tetramer interface [polypeptide binding]; other site 176279006687 TPP-binding site [chemical binding]; other site 176279006688 heterodimer interface [polypeptide binding]; other site 176279006689 phosphorylation loop region [posttranslational modification] 176279006690 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 176279006691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 176279006692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 176279006693 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 176279006694 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 176279006695 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 176279006696 transmembrane helices; other site 176279006697 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 176279006698 NMT1/THI5 like; Region: NMT1; pfam09084 176279006699 Predicted permeases [General function prediction only]; Region: RarD; COG2962 176279006700 MepB protein; Region: MepB; pfam08877 176279006701 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 176279006702 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 176279006703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006704 putative substrate translocation pore; other site 176279006705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006706 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 176279006707 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 176279006708 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 176279006709 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 176279006710 Condensation domain; Region: Condensation; pfam00668 176279006711 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 176279006712 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 176279006713 acyl-activating enzyme (AAE) consensus motif; other site 176279006714 AMP binding site [chemical binding]; other site 176279006715 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 176279006716 Condensation domain; Region: Condensation; pfam00668 176279006717 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 176279006718 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 176279006719 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 176279006720 acyl-activating enzyme (AAE) consensus motif; other site 176279006721 AMP binding site [chemical binding]; other site 176279006722 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 176279006723 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 176279006724 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 176279006725 putative NAD(P) binding site [chemical binding]; other site 176279006726 active site 176279006727 putative substrate binding site [chemical binding]; other site 176279006728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006729 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279006730 putative substrate translocation pore; other site 176279006731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006732 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279006733 putative substrate translocation pore; other site 176279006734 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 176279006735 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 176279006736 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 176279006737 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 176279006738 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 176279006739 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 176279006740 dimer interface [polypeptide binding]; other site 176279006741 active site 176279006742 metal binding site [ion binding]; metal-binding site 176279006743 biotin synthase; Validated; Region: PRK06256 176279006744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279006745 FeS/SAM binding site; other site 176279006746 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 176279006747 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 176279006748 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 176279006749 active site 176279006750 metal binding site [ion binding]; metal-binding site 176279006751 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 176279006752 ornithine carbamoyltransferase; Provisional; Region: PRK04284 176279006753 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 176279006754 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 176279006755 carbamate kinase; Reviewed; Region: PRK12686 176279006756 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 176279006757 putative substrate binding site [chemical binding]; other site 176279006758 nucleotide binding site [chemical binding]; other site 176279006759 nucleotide binding site [chemical binding]; other site 176279006760 homodimer interface [polypeptide binding]; other site 176279006761 Predicted membrane protein [Function unknown]; Region: COG1288 176279006762 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 176279006763 Predicted esterase [General function prediction only]; Region: COG0627 176279006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 176279006765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279006766 dimer interface [polypeptide binding]; other site 176279006767 conserved gate region; other site 176279006768 ABC-ATPase subunit interface; other site 176279006769 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 176279006770 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 176279006771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279006772 dimer interface [polypeptide binding]; other site 176279006773 conserved gate region; other site 176279006774 putative PBP binding loops; other site 176279006775 ABC-ATPase subunit interface; other site 176279006776 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 176279006777 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 176279006778 Walker A/P-loop; other site 176279006779 ATP binding site [chemical binding]; other site 176279006780 Q-loop/lid; other site 176279006781 ABC transporter signature motif; other site 176279006782 Walker B; other site 176279006783 D-loop; other site 176279006784 H-loop/switch region; other site 176279006785 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 176279006786 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 176279006787 active site 176279006788 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 176279006789 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 176279006790 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 176279006791 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 176279006792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 176279006793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176279006794 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 176279006795 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 176279006796 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 176279006797 metal binding site [ion binding]; metal-binding site 176279006798 dimer interface [polypeptide binding]; other site 176279006799 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 176279006800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 176279006801 FeS/SAM binding site; other site 176279006802 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 176279006803 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 176279006804 Pyruvate formate lyase 1; Region: PFL1; cd01678 176279006805 coenzyme A binding site [chemical binding]; other site 176279006806 active site 176279006807 catalytic residues [active] 176279006808 glycine loop; other site 176279006809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006810 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279006811 putative substrate translocation pore; other site 176279006812 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 176279006813 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176279006814 Walker A/P-loop; other site 176279006815 ATP binding site [chemical binding]; other site 176279006816 Q-loop/lid; other site 176279006817 ABC transporter signature motif; other site 176279006818 Walker B; other site 176279006819 D-loop; other site 176279006820 H-loop/switch region; other site 176279006821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 176279006822 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 176279006823 Walker A/P-loop; other site 176279006824 ATP binding site [chemical binding]; other site 176279006825 Q-loop/lid; other site 176279006826 ABC transporter signature motif; other site 176279006827 Walker B; other site 176279006828 D-loop; other site 176279006829 H-loop/switch region; other site 176279006830 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 176279006831 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 176279006832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279006833 dimer interface [polypeptide binding]; other site 176279006834 conserved gate region; other site 176279006835 putative PBP binding loops; other site 176279006836 ABC-ATPase subunit interface; other site 176279006837 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 176279006838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 176279006839 dimer interface [polypeptide binding]; other site 176279006840 conserved gate region; other site 176279006841 putative PBP binding loops; other site 176279006842 ABC-ATPase subunit interface; other site 176279006843 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 176279006844 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 176279006845 substrate binding site [chemical binding]; other site 176279006846 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 176279006847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 176279006848 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 176279006849 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 176279006850 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 176279006851 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 176279006852 Walker A/P-loop; other site 176279006853 ATP binding site [chemical binding]; other site 176279006854 Q-loop/lid; other site 176279006855 ABC transporter signature motif; other site 176279006856 Walker B; other site 176279006857 D-loop; other site 176279006858 H-loop/switch region; other site 176279006859 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 176279006860 acetoin reductases; Region: 23BDH; TIGR02415 176279006861 NAD binding site [chemical binding]; other site 176279006862 homotetramer interface [polypeptide binding]; other site 176279006863 homodimer interface [polypeptide binding]; other site 176279006864 active site 176279006865 substrate binding site [chemical binding]; other site 176279006866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279006867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 176279006868 putative substrate translocation pore; other site 176279006869 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 176279006870 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 176279006871 putative active site [active] 176279006872 putative FMN binding site [chemical binding]; other site 176279006873 putative substrate binding site [chemical binding]; other site 176279006874 putative catalytic residue [active] 176279006875 FMN-binding domain; Region: FMN_bind; cl01081 176279006876 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 176279006877 L-aspartate oxidase; Provisional; Region: PRK06175 176279006878 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 176279006879 ApbE family; Region: ApbE; pfam02424 176279006880 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 176279006881 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 176279006882 intersubunit interface [polypeptide binding]; other site 176279006883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 176279006884 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 176279006885 Nucleoside recognition; Region: Gate; pfam07670 176279006886 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 176279006887 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 176279006888 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 176279006889 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 176279006890 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 176279006891 Staphostatin A; Region: Staphostatin_A; pfam09022 176279006892 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176279006893 Cadherin repeat-like domain; Region: CA_like; cl15786 176279006894 Cadherin repeat-like domain; Region: CA_like; cl15786 176279006895 Ca2+ binding site [ion binding]; other site 176279006896 Cadherin repeat-like domain; Region: CA_like; cl15786 176279006897 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 176279006898 Ca2+ binding site [ion binding]; other site 176279006899 Cadherin repeat-like domain; Region: CA_like; cl15786 176279006900 Ca2+ binding site [ion binding]; other site 176279006901 Cadherin repeat-like domain; Region: CA_like; cl15786 176279006902 Ca2+ binding site [ion binding]; other site 176279006903 Putative Ig domain; Region: He_PIG; pfam05345 176279006904 Putative Ig domain; Region: He_PIG; pfam05345 176279006905 Cadherin repeat-like domain; Region: CA_like; cl15786 176279006906 Ca2+ binding site [ion binding]; other site 176279006907 Putative Ig domain; Region: He_PIG; pfam05345 176279006908 Cadherin repeat-like domain; Region: CA_like; cl15786 176279006909 Ca2+ binding site [ion binding]; other site 176279006910 Putative Ig domain; Region: He_PIG; pfam05345 176279006911 Putative Ig domain; Region: He_PIG; pfam05345 176279006912 Cadherin repeat-like domain; Region: CA_like; cl15786 176279006913 Ca2+ binding site [ion binding]; other site 176279006914 Cadherin repeat-like domain; Region: CA_like; cl15786 176279006915 Ca2+ binding site [ion binding]; other site 176279006916 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 176279006917 6-carboxyhexanoate--CoA ligase; Region: BioW; pfam03744 176279006918 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 176279006919 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 176279006920 substrate-cofactor binding pocket; other site 176279006921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279006922 catalytic residue [active] 176279006923 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 176279006924 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 176279006925 inhibitor-cofactor binding pocket; inhibition site 176279006926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 176279006927 catalytic residue [active] 176279006928 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 176279006929 AAA domain; Region: AAA_26; pfam13500 176279006930 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176279006931 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 176279006932 MARCKS family; Region: MARCKS; pfam02063 176279006933 legume lectins; Region: lectin_L-type; cl14058 176279006934 homotetramer interaction site [polypeptide binding]; other site 176279006935 homodimer interaction site [polypeptide binding]; other site 176279006936 carbohydrate binding site [chemical binding]; other site 176279006937 metal binding site [ion binding]; metal-binding site 176279006938 G5 domain; Region: G5; pfam07501 176279006939 G5 domain; Region: G5; pfam07501 176279006940 G5 domain; Region: G5; pfam07501 176279006941 G5 domain; Region: G5; pfam07501 176279006942 G5 domain; Region: G5; pfam07501 176279006943 G5 domain; Region: G5; pfam07501 176279006944 G5 domain; Region: G5; pfam07501 176279006945 G5 domain; Region: G5; pfam07501 176279006946 G5 domain; Region: G5; pfam07501 176279006947 G5 domain; Region: G5; pfam07501 176279006948 G5 domain; Region: G5; pfam07501 176279006949 G5 domain; Region: G5; pfam07501 176279006950 G5 domain; Region: G5; pfam07501 176279006951 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 176279006952 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 176279006953 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 176279006954 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 176279006955 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 176279006956 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 176279006957 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 176279006958 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 176279006959 Histidine kinase; Region: His_kinase; pfam06580 176279006960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279006961 ATP binding site [chemical binding]; other site 176279006962 Mg2+ binding site [ion binding]; other site 176279006963 G-X-G motif; other site 176279006964 Response regulator receiver domain; Region: Response_reg; pfam00072 176279006965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279006966 active site 176279006967 phosphorylation site [posttranslational modification] 176279006968 intermolecular recognition site; other site 176279006969 dimerization interface [polypeptide binding]; other site 176279006970 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 176279006971 Phospholipid methyltransferase; Region: PEMT; cl17370 176279006972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 176279006973 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 176279006974 NAD(P) binding site [chemical binding]; other site 176279006975 active site 176279006976 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 176279006977 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 176279006978 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 176279006979 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 176279006980 FMN binding site [chemical binding]; other site 176279006981 active site 176279006982 catalytic residues [active] 176279006983 substrate binding site [chemical binding]; other site 176279006984 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 176279006985 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 176279006986 Mechanosensitive ion channel; Region: MS_channel; pfam00924 176279006987 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176279006988 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176279006989 Predicted permeases [General function prediction only]; Region: COG0701 176279006990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176279006991 dimerization interface [polypeptide binding]; other site 176279006992 putative DNA binding site [nucleotide binding]; other site 176279006993 putative Zn2+ binding site [ion binding]; other site 176279006994 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 176279006995 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 176279006996 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 176279006997 P loop; other site 176279006998 Nucleotide binding site [chemical binding]; other site 176279006999 DTAP/Switch II; other site 176279007000 Switch I; other site 176279007001 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 176279007002 P loop; other site 176279007003 Nucleotide binding site [chemical binding]; other site 176279007004 DTAP/Switch II; other site 176279007005 Switch I; other site 176279007006 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 176279007007 dimerization interface [polypeptide binding]; other site 176279007008 putative DNA binding site [nucleotide binding]; other site 176279007009 putative Zn2+ binding site [ion binding]; other site 176279007010 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 176279007011 arsenical pump membrane protein; Provisional; Region: PRK15445 176279007012 transmembrane helices; other site 176279007013 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 176279007014 Low molecular weight phosphatase family; Region: LMWPc; cd00115 176279007015 active site 176279007016 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 176279007017 putative homodimer interface [polypeptide binding]; other site 176279007018 putative homotetramer interface [polypeptide binding]; other site 176279007019 putative metal binding site [ion binding]; other site 176279007020 putative homodimer-homodimer interface [polypeptide binding]; other site 176279007021 putative allosteric switch controlling residues; other site 176279007022 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176279007023 active site residue [active] 176279007024 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 176279007025 CPxP motif; other site 176279007026 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 176279007027 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 176279007028 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176279007029 active site residue [active] 176279007030 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176279007031 active site residue [active] 176279007032 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 176279007033 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 176279007034 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 176279007035 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 176279007036 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 176279007037 Soluble P-type ATPase [General function prediction only]; Region: COG4087 176279007038 MFS/sugar transport protein; Region: MFS_2; pfam13347 176279007039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 176279007040 putative substrate translocation pore; other site 176279007041 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176279007042 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176279007043 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176279007044 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176279007045 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176279007046 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 176279007047 GIY-YIG motif/motif A; other site 176279007048 putative active site [active] 176279007049 putative metal binding site [ion binding]; other site 176279007050 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 176279007051 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 176279007052 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 176279007053 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 176279007054 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 176279007055 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 176279007056 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 176279007057 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 176279007058 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 176279007059 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 176279007060 HsdM N-terminal domain; Region: HsdM_N; pfam12161 176279007061 Protein of unknown function, DUF576; Region: DUF576; pfam04507 176279007062 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 176279007063 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 176279007064 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 176279007065 NAD binding site [chemical binding]; other site 176279007066 catalytic Zn binding site [ion binding]; other site 176279007067 substrate binding site [chemical binding]; other site 176279007068 structural Zn binding site [ion binding]; other site 176279007069 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 176279007070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279007071 Coenzyme A binding pocket [chemical binding]; other site 176279007072 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 176279007073 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 176279007074 HsdM N-terminal domain; Region: HsdM_N; pfam12161 176279007075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279007076 S-adenosylmethionine binding site [chemical binding]; other site 176279007077 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 176279007078 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 176279007079 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 176279007080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 176279007081 ATP binding site [chemical binding]; other site 176279007082 putative Mg++ binding site [ion binding]; other site 176279007083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279007084 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 176279007085 Walker A motif; other site 176279007086 ATP binding site [chemical binding]; other site 176279007087 Walker B motif; other site 176279007088 AAA domain; Region: AAA_13; pfam13166 176279007089 AAA domain; Region: AAA_13; pfam13166 176279007090 SEFIR domain; Region: SEFIR; pfam08357 176279007091 Protein kinase domain; Region: Pkinase; pfam00069 176279007092 Catalytic domain of Protein Kinases; Region: PKc; cd00180 176279007093 active site 176279007094 ATP binding site [chemical binding]; other site 176279007095 substrate binding site [chemical binding]; other site 176279007096 activation loop (A-loop); other site 176279007097 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 176279007098 potassium-transporting ATPase subunit C; Provisional; Region: PRK14000 176279007099 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 176279007100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 176279007101 Soluble P-type ATPase [General function prediction only]; Region: COG4087 176279007102 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 176279007103 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 176279007104 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 176279007105 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 176279007106 Ligand Binding Site [chemical binding]; other site 176279007107 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 176279007108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176279007109 dimer interface [polypeptide binding]; other site 176279007110 phosphorylation site [posttranslational modification] 176279007111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279007112 ATP binding site [chemical binding]; other site 176279007113 Mg2+ binding site [ion binding]; other site 176279007114 G-X-G motif; other site 176279007115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176279007116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279007117 active site 176279007118 phosphorylation site [posttranslational modification] 176279007119 intermolecular recognition site; other site 176279007120 dimerization interface [polypeptide binding]; other site 176279007121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176279007122 DNA binding site [nucleotide binding] 176279007123 Predicted membrane protein [Function unknown]; Region: COG1288 176279007124 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 176279007125 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 176279007126 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176279007127 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 176279007128 catalytic residues [active] 176279007129 catalytic nucleophile [active] 176279007130 Recombinase; Region: Recombinase; pfam07508 176279007131 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 176279007132 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 176279007133 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176279007134 catalytic residues [active] 176279007135 catalytic nucleophile [active] 176279007136 Presynaptic Site I dimer interface [polypeptide binding]; other site 176279007137 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176279007138 Synaptic Flat tetramer interface [polypeptide binding]; other site 176279007139 Synaptic Site I dimer interface [polypeptide binding]; other site 176279007140 DNA binding site [nucleotide binding] 176279007141 Recombinase; Region: Recombinase; pfam07508 176279007142 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 176279007143 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 176279007144 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 176279007145 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 176279007146 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 176279007147 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 176279007148 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 176279007149 MPN+ (JAMM) motif; other site 176279007150 Zinc-binding site [ion binding]; other site 176279007151 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 176279007152 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 176279007153 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 176279007154 Int/Topo IB signature motif; other site 176279007155 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 176279007156 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 176279007157 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 176279007158 Int/Topo IB signature motif; other site 176279007159 aminoglycoside resistance protein; Provisional; Region: PRK13746 176279007160 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 176279007161 active site 176279007162 NTP binding site [chemical binding]; other site 176279007163 metal binding triad [ion binding]; metal-binding site 176279007164 antibiotic binding site [chemical binding]; other site 176279007165 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 176279007166 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 176279007167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279007168 S-adenosylmethionine binding site [chemical binding]; other site 176279007169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279007170 S-adenosylmethionine binding site [chemical binding]; other site 176279007171 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 176279007172 putative homodimer interface [polypeptide binding]; other site 176279007173 putative homotetramer interface [polypeptide binding]; other site 176279007174 putative metal binding site [ion binding]; other site 176279007175 putative homodimer-homodimer interface [polypeptide binding]; other site 176279007176 putative allosteric switch controlling residues; other site 176279007177 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 176279007178 active site residue [active] 176279007179 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 176279007180 CPxP motif; other site 176279007181 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 176279007182 MarR family; Region: MarR_2; pfam12802 176279007183 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 176279007184 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 176279007185 nucleotide binding site [chemical binding]; other site 176279007186 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 176279007187 Predicted transcriptional regulator [Transcription]; Region: COG3682 176279007188 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 176279007189 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 176279007190 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 176279007191 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 176279007192 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 176279007193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 176279007194 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 176279007195 putative active site [active] 176279007196 putative catalytic site [active] 176279007197 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 176279007198 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 176279007199 putative active site [active] 176279007200 catalytic site [active] 176279007201 putative metal binding site [ion binding]; other site 176279007202 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 176279007203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176279007204 Integrase core domain; Region: rve; pfam00665 176279007205 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 176279007206 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 176279007207 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 176279007208 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 176279007209 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 176279007210 YycH protein; Region: YycI; cl02015 176279007211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 176279007212 YycH protein; Region: YycH; pfam07435 176279007213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 176279007214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 176279007215 dimerization interface [polypeptide binding]; other site 176279007216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 176279007217 putative active site [active] 176279007218 heme pocket [chemical binding]; other site 176279007219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 176279007220 dimer interface [polypeptide binding]; other site 176279007221 phosphorylation site [posttranslational modification] 176279007222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279007223 ATP binding site [chemical binding]; other site 176279007224 Mg2+ binding site [ion binding]; other site 176279007225 G-X-G motif; other site 176279007226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 176279007227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 176279007228 active site 176279007229 phosphorylation site [posttranslational modification] 176279007230 intermolecular recognition site; other site 176279007231 dimerization interface [polypeptide binding]; other site 176279007232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 176279007233 DNA binding site [nucleotide binding] 176279007234 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 176279007235 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 176279007236 GDP-binding site [chemical binding]; other site 176279007237 ACT binding site; other site 176279007238 IMP binding site; other site 176279007239 replicative DNA helicase; Region: DnaB; TIGR00665 176279007240 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 176279007241 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 176279007242 Walker A motif; other site 176279007243 ATP binding site [chemical binding]; other site 176279007244 Walker B motif; other site 176279007245 DNA binding loops [nucleotide binding] 176279007246 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 176279007247 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 176279007248 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 176279007249 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 176279007250 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 176279007251 DHH family; Region: DHH; pfam01368 176279007252 DHHA1 domain; Region: DHHA1; pfam02272 176279007253 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 176279007254 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 176279007255 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 176279007256 Predicted membrane protein [Function unknown]; Region: COG4392 176279007257 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 176279007258 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 176279007259 putative catalytic site [active] 176279007260 metal binding site A [ion binding]; metal-binding site 176279007261 phosphate binding site [ion binding]; other site 176279007262 metal binding site C [ion binding]; metal-binding site 176279007263 metal binding site B [ion binding]; metal-binding site 176279007264 seryl-tRNA synthetase; Provisional; Region: PRK05431 176279007265 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 176279007266 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 176279007267 dimer interface [polypeptide binding]; other site 176279007268 active site 176279007269 motif 1; other site 176279007270 motif 2; other site 176279007271 motif 3; other site 176279007272 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 176279007273 putative substrate binding site [chemical binding]; other site 176279007274 putative ATP binding site [chemical binding]; other site 176279007275 DNA gyrase subunit A; Validated; Region: PRK05560 176279007276 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 176279007277 CAP-like domain; other site 176279007278 active site 176279007279 primary dimer interface [polypeptide binding]; other site 176279007280 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176279007281 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176279007282 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176279007283 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176279007284 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176279007285 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 176279007286 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 176279007287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 176279007288 Mg2+ binding site [ion binding]; other site 176279007289 G-X-G motif; other site 176279007290 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 176279007291 anchoring element; other site 176279007292 dimer interface [polypeptide binding]; other site 176279007293 ATP binding site [chemical binding]; other site 176279007294 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 176279007295 active site 176279007296 putative metal-binding site [ion binding]; other site 176279007297 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 176279007298 recombination protein F; Reviewed; Region: recF; PRK00064 176279007299 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 176279007300 Walker A/P-loop; other site 176279007301 ATP binding site [chemical binding]; other site 176279007302 Q-loop/lid; other site 176279007303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279007304 ABC transporter signature motif; other site 176279007305 Walker B; other site 176279007306 D-loop; other site 176279007307 H-loop/switch region; other site 176279007308 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 176279007309 DNA polymerase III subunit beta; Validated; Region: PRK05643 176279007310 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 176279007311 putative DNA binding surface [nucleotide binding]; other site 176279007312 dimer interface [polypeptide binding]; other site 176279007313 beta-clamp/clamp loader binding surface; other site 176279007314 beta-clamp/translesion DNA polymerase binding surface; other site 176279007315 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 176279007316 DnaA N-terminal domain; Region: DnaA_N; pfam11638 176279007317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 176279007318 Walker A motif; other site 176279007319 ATP binding site [chemical binding]; other site 176279007320 Walker B motif; other site 176279007321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 176279007322 arginine finger; other site 176279007323 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 176279007324 DnaA box-binding interface [nucleotide binding]; other site 176279007325 HTH domain; Region: HTH_11; cl17392 176279007326 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 176279007327 Switch II region; other site 176279007328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176279007329 Integrase core domain; Region: rve; pfam00665 176279007330 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 176279007331 beta-lactamase TEM; Provisional; Region: PRK15442 176279007332 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 176279007333 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 176279007334 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 176279007335 Predicted transcriptional regulator [Transcription]; Region: COG3682 176279007336 multiple promoter invertase; Provisional; Region: mpi; PRK13413 176279007337 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 176279007338 catalytic residues [active] 176279007339 catalytic nucleophile [active] 176279007340 Presynaptic Site I dimer interface [polypeptide binding]; other site 176279007341 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 176279007342 Synaptic Flat tetramer interface [polypeptide binding]; other site 176279007343 Synaptic Site I dimer interface [polypeptide binding]; other site 176279007344 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 176279007345 DNA-binding interface [nucleotide binding]; DNA binding site 176279007346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176279007347 Integrase core domain; Region: rve; pfam00665 176279007348 HTH domain; Region: HTH_11; pfam08279 176279007349 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 176279007350 active site 176279007351 ATP binding site [chemical binding]; other site 176279007352 Phosphotransferase enzyme family; Region: APH; pfam01636 176279007353 antibiotic binding site [chemical binding]; other site 176279007354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 176279007355 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 176279007356 Coenzyme A binding pocket [chemical binding]; other site 176279007357 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 176279007358 Methyltransferase domain; Region: Methyltransf_31; pfam13847 176279007359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 176279007360 S-adenosylmethionine binding site [chemical binding]; other site 176279007361 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 176279007362 active site 176279007363 NTP binding site [chemical binding]; other site 176279007364 metal binding triad [ion binding]; metal-binding site 176279007365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 176279007366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 176279007367 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 176279007368 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 176279007369 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 176279007370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 176279007371 Walker A/P-loop; other site 176279007372 ATP binding site [chemical binding]; other site 176279007373 Q-loop/lid; other site 176279007374 ABC transporter signature motif; other site 176279007375 Walker B; other site 176279007376 D-loop; other site 176279007377 H-loop/switch region; other site 176279007378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176279007379 Integrase core domain; Region: rve; pfam00665 176279007380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 176279007381 Integrase core domain; Region: rve; pfam00665 176279007382 Initiator Replication protein; Region: Rep_3; pfam01051 176279007383 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 176279007384 Ligand Binding Site [chemical binding]; other site 176279007385 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 176279007386 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 176279007387 Sulfate transporter family; Region: Sulfate_transp; pfam00916 176279007388 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 176279007389 multiple promoter invertase; Provisional; Region: mpi; PRK13413 176279007390 Resolvase, N terminal domain; Region: Resolvase; pfam00239 176279007391 catalytic residues [active] 176279007392 catalytic nucleophile [active] 176279007393 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 176279007394 DNA-binding interface [nucleotide binding]; DNA binding site 176279007395 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 176279007396 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 176279007397 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 176279007398 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970