-- dump date   	20140620_075552
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
451516000001	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
451516000002	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
451516000003	Cadmium resistance transporter; Region: Cad; pfam03596
451516000004	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
451516000005	putative DNA binding site [nucleotide binding]; other site
451516000006	putative Zn2+ binding site [ion binding]; other site
451516000007	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
451516000008	MarR family; Region: MarR_2; pfam12802
451516000009	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
451516000010	beta-lactamase TEM; Provisional; Region: PRK15442
451516000011	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
451516000012	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
451516000013	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
451516000014	Predicted transcriptional regulator [Transcription]; Region: COG3682
451516000015	multiple promoter invertase; Provisional; Region: mpi; PRK13413
451516000016	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
451516000017	catalytic residues [active]
451516000018	catalytic nucleophile [active]
451516000019	Presynaptic Site I dimer interface [polypeptide binding]; other site
451516000020	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
451516000021	Synaptic Flat tetramer interface [polypeptide binding]; other site
451516000022	Synaptic Site I dimer interface [polypeptide binding]; other site
451516000023	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
451516000024	DNA-binding interface [nucleotide binding]; DNA binding site
451516000025	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
451516000026	Integrase core domain; Region: rve; pfam00665
451516000027	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
451516000028	active site
451516000029	ATP binding site [chemical binding]; other site
451516000030	Phosphotransferase enzyme family; Region: APH; pfam01636
451516000031	antibiotic binding site [chemical binding]; other site
451516000032	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516000033	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
451516000034	Coenzyme A binding pocket [chemical binding]; other site
451516000035	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
451516000036	Integrase core domain; Region: rve; pfam00665
451516000037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
451516000038	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
451516000039	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
451516000040	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516000041	Walker A/P-loop; other site
451516000042	ATP binding site [chemical binding]; other site
451516000043	Q-loop/lid; other site
451516000044	ABC transporter signature motif; other site
451516000045	Walker B; other site
451516000046	D-loop; other site
451516000047	H-loop/switch region; other site
451516000048	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
451516000049	Integrase core domain; Region: rve; pfam00665
451516000050	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
451516000051	ABC transporter; Region: ABC_tran; pfam00005
451516000052	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
451516000053	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
451516000054	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
451516000055	Phosphotransferase enzyme family; Region: APH; pfam01636
451516000056	putative active site [active]
451516000057	putative substrate binding site [chemical binding]; other site
451516000058	ATP binding site [chemical binding]; other site
451516000059	multiple promoter invertase; Provisional; Region: mpi; PRK13413
451516000060	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
451516000061	catalytic residues [active]
451516000062	catalytic nucleophile [active]
451516000063	Presynaptic Site I dimer interface [polypeptide binding]; other site
451516000064	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
451516000065	Synaptic Flat tetramer interface [polypeptide binding]; other site
451516000066	Synaptic Site I dimer interface [polypeptide binding]; other site
451516000067	DNA binding site [nucleotide binding]
451516000068	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
451516000069	DNA-binding interface [nucleotide binding]; DNA binding site
451516000070	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516000071	non-specific DNA binding site [nucleotide binding]; other site
451516000072	salt bridge; other site
451516000073	sequence-specific DNA binding site [nucleotide binding]; other site
451516000074	DNA topoisomerase II; Provisional; Region: PTZ00108
451516000075	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
451516000076	DnaA N-terminal domain; Region: DnaA_N; pfam11638
451516000077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516000078	Walker A motif; other site
451516000079	ATP binding site [chemical binding]; other site
451516000080	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
451516000081	Walker B motif; other site
451516000082	arginine finger; other site
451516000083	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
451516000084	DnaA box-binding interface [nucleotide binding]; other site
451516000085	DNA polymerase III subunit beta; Validated; Region: PRK05643
451516000086	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
451516000087	putative DNA binding surface [nucleotide binding]; other site
451516000088	dimer interface [polypeptide binding]; other site
451516000089	beta-clamp/clamp loader binding surface; other site
451516000090	beta-clamp/translesion DNA polymerase binding surface; other site
451516000091	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
451516000092	recF protein; Region: recf; TIGR00611
451516000093	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
451516000094	Walker A/P-loop; other site
451516000095	ATP binding site [chemical binding]; other site
451516000096	Q-loop/lid; other site
451516000097	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516000098	ABC transporter signature motif; other site
451516000099	Walker B; other site
451516000100	D-loop; other site
451516000101	H-loop/switch region; other site
451516000102	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
451516000103	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516000104	Mg2+ binding site [ion binding]; other site
451516000105	G-X-G motif; other site
451516000106	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
451516000107	anchoring element; other site
451516000108	dimer interface [polypeptide binding]; other site
451516000109	ATP binding site [chemical binding]; other site
451516000110	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
451516000111	active site
451516000112	putative metal-binding site [ion binding]; other site
451516000113	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
451516000114	DNA gyrase subunit A; Validated; Region: PRK05560
451516000115	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
451516000116	CAP-like domain; other site
451516000117	active site
451516000118	primary dimer interface [polypeptide binding]; other site
451516000119	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
451516000120	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
451516000121	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
451516000122	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
451516000123	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
451516000124	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
451516000125	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
451516000126	putative substrate binding site [chemical binding]; other site
451516000127	putative ATP binding site [chemical binding]; other site
451516000128	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
451516000129	active sites [active]
451516000130	tetramer interface [polypeptide binding]; other site
451516000131	seryl-tRNA synthetase; Provisional; Region: PRK05431
451516000132	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
451516000133	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
451516000134	dimer interface [polypeptide binding]; other site
451516000135	active site
451516000136	motif 1; other site
451516000137	motif 2; other site
451516000138	motif 3; other site
451516000139	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
451516000140	Predicted membrane protein [Function unknown]; Region: COG4392
451516000141	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
451516000142	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
451516000143	Predicted membrane protein [Function unknown]; Region: COG4241
451516000144	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
451516000145	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
451516000146	DHH family; Region: DHH; pfam01368
451516000147	DHHA1 domain; Region: DHHA1; pfam02272
451516000148	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
451516000149	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
451516000150	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
451516000151	replicative DNA helicase; Region: DnaB; TIGR00665
451516000152	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
451516000153	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
451516000154	Walker A motif; other site
451516000155	ATP binding site [chemical binding]; other site
451516000156	Walker B motif; other site
451516000157	DNA binding loops [nucleotide binding]
451516000158	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
451516000159	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
451516000160	GDP-binding site [chemical binding]; other site
451516000161	ACT binding site; other site
451516000162	IMP binding site; other site
451516000163	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
451516000164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516000165	active site
451516000166	phosphorylation site [posttranslational modification]
451516000167	intermolecular recognition site; other site
451516000168	dimerization interface [polypeptide binding]; other site
451516000169	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
451516000170	DNA binding site [nucleotide binding]
451516000171	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
451516000172	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
451516000173	dimerization interface [polypeptide binding]; other site
451516000174	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
451516000175	putative active site [active]
451516000176	heme pocket [chemical binding]; other site
451516000177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
451516000178	dimer interface [polypeptide binding]; other site
451516000179	phosphorylation site [posttranslational modification]
451516000180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516000181	ATP binding site [chemical binding]; other site
451516000182	Mg2+ binding site [ion binding]; other site
451516000183	G-X-G motif; other site
451516000184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
451516000185	YycH protein; Region: YycH; pfam07435
451516000186	YycH protein; Region: YycI; cl02015
451516000187	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
451516000188	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
451516000189	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
451516000190	putative active site [active]
451516000191	putative metal binding site [ion binding]; other site
451516000192	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
451516000193	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
451516000194	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
451516000195	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
451516000196	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
451516000197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
451516000198	Integrase core domain; Region: rve; pfam00665
451516000199	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
451516000200	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
451516000201	putative active site [active]
451516000202	catalytic site [active]
451516000203	putative metal binding site [ion binding]; other site
451516000204	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
451516000205	putative active site [active]
451516000206	putative catalytic site [active]
451516000207	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
451516000208	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
451516000209	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
451516000210	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
451516000211	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
451516000212	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
451516000213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
451516000214	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
451516000215	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
451516000216	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
451516000217	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
451516000218	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
451516000219	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
451516000220	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
451516000221	catalytic residues [active]
451516000222	catalytic nucleophile [active]
451516000223	Presynaptic Site I dimer interface [polypeptide binding]; other site
451516000224	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
451516000225	Synaptic Flat tetramer interface [polypeptide binding]; other site
451516000226	Synaptic Site I dimer interface [polypeptide binding]; other site
451516000227	DNA binding site [nucleotide binding]
451516000228	Recombinase; Region: Recombinase; pfam07508
451516000229	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
451516000230	Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262
451516000231	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
451516000232	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
451516000233	catalytic residues [active]
451516000234	catalytic nucleophile [active]
451516000235	Recombinase; Region: Recombinase; pfam07508
451516000236	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
451516000237	Domain of unknown function (DUF927); Region: DUF927; pfam06048
451516000238	Domain of unknown function (DUF1413); Region: DUF1413; pfam07205
451516000239	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
451516000240	Divergent AAA domain; Region: AAA_4; pfam04326
451516000241	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
451516000242	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
451516000243	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
451516000244	HNH endonuclease; Region: HNH_2; pfam13391
451516000245	Tic20-like protein; Region: Tic20; pfam09685
451516000246	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
451516000247	Helix-turn-helix domain; Region: HTH_28; pfam13518
451516000248	HTH-like domain; Region: HTH_21; pfam13276
451516000249	Integrase core domain; Region: rve; pfam00665
451516000250	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
451516000251	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516000252	Coenzyme A binding pocket [chemical binding]; other site
451516000253	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
451516000254	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
451516000255	NAD binding site [chemical binding]; other site
451516000256	catalytic Zn binding site [ion binding]; other site
451516000257	substrate binding site [chemical binding]; other site
451516000258	structural Zn binding site [ion binding]; other site
451516000259	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
451516000260	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
451516000261	Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106
451516000262	putative transposase OrfB; Reviewed; Region: PHA02517
451516000263	HTH-like domain; Region: HTH_21; pfam13276
451516000264	Integrase core domain; Region: rve; pfam00665
451516000265	Integrase core domain; Region: rve_3; cl15866
451516000266	carbamate kinase; Reviewed; Region: PRK12686
451516000267	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
451516000268	putative substrate binding site [chemical binding]; other site
451516000269	nucleotide binding site [chemical binding]; other site
451516000270	nucleotide binding site [chemical binding]; other site
451516000271	homodimer interface [polypeptide binding]; other site
451516000272	ornithine carbamoyltransferase; Provisional; Region: PRK04284
451516000273	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
451516000274	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
451516000275	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
451516000276	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
451516000277	ligand binding site [chemical binding]; other site
451516000278	flexible hinge region; other site
451516000279	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
451516000280	putative switch regulator; other site
451516000281	non-specific DNA interactions [nucleotide binding]; other site
451516000282	DNA binding site [nucleotide binding]
451516000283	sequence specific DNA binding site [nucleotide binding]; other site
451516000284	putative cAMP binding site [chemical binding]; other site
451516000285	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
451516000286	arginine deiminase; Provisional; Region: PRK01388
451516000287	Arginine repressor [Transcription]; Region: ArgR; COG1438
451516000288	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
451516000289	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
451516000290	Ligand Binding Site [chemical binding]; other site
451516000291	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
451516000292	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
451516000293	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
451516000294	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
451516000295	Methyltransferase domain; Region: Methyltransf_23; pfam13489
451516000296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516000297	S-adenosylmethionine binding site [chemical binding]; other site
451516000298	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
451516000299	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
451516000300	substrate binding site [chemical binding]; other site
451516000301	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
451516000302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516000303	dimer interface [polypeptide binding]; other site
451516000304	conserved gate region; other site
451516000305	putative PBP binding loops; other site
451516000306	ABC-ATPase subunit interface; other site
451516000307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
451516000308	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
451516000309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516000310	dimer interface [polypeptide binding]; other site
451516000311	conserved gate region; other site
451516000312	putative PBP binding loops; other site
451516000313	ABC-ATPase subunit interface; other site
451516000314	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
451516000315	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516000316	Walker A/P-loop; other site
451516000317	ATP binding site [chemical binding]; other site
451516000318	Q-loop/lid; other site
451516000319	ABC transporter signature motif; other site
451516000320	Walker B; other site
451516000321	D-loop; other site
451516000322	H-loop/switch region; other site
451516000323	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
451516000324	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516000325	Walker A/P-loop; other site
451516000326	ATP binding site [chemical binding]; other site
451516000327	Q-loop/lid; other site
451516000328	ABC transporter signature motif; other site
451516000329	Walker B; other site
451516000330	D-loop; other site
451516000331	H-loop/switch region; other site
451516000332	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
451516000333	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
451516000334	Soluble P-type ATPase [General function prediction only]; Region: COG4087
451516000335	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
451516000336	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
451516000337	Protein of unknown function (DUF1541); Region: DUF1541; pfam07563
451516000338	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
451516000339	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
451516000340	putative homodimer interface [polypeptide binding]; other site
451516000341	putative homotetramer interface [polypeptide binding]; other site
451516000342	putative metal binding site [ion binding]; other site
451516000343	putative homodimer-homodimer interface [polypeptide binding]; other site
451516000344	putative allosteric switch controlling residues; other site
451516000345	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
451516000346	active site residue [active]
451516000347	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
451516000348	CPxP  motif; other site
451516000349	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
451516000350	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
451516000351	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
451516000352	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
451516000353	active site residue [active]
451516000354	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
451516000355	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
451516000356	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
451516000357	FMN binding site [chemical binding]; other site
451516000358	active site
451516000359	catalytic residues [active]
451516000360	substrate binding site [chemical binding]; other site
451516000361	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
451516000362	H+ Antiporter protein; Region: 2A0121; TIGR00900
451516000363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516000364	putative substrate translocation pore; other site
451516000365	Transcriptional regulator [Transcription]; Region: LysR; COG0583
451516000366	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
451516000367	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
451516000368	dimerization interface [polypeptide binding]; other site
451516000369	Transcriptional regulator [Transcription]; Region: LysR; COG0583
451516000370	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
451516000371	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
451516000372	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
451516000373	Part of AAA domain; Region: AAA_19; pfam13245
451516000374	AAA domain; Region: AAA_12; pfam13087
451516000375	Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586
451516000376	active site
451516000377	catalytic site [active]
451516000378	putative metal binding site [ion binding]; other site
451516000379	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516000380	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516000381	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516000382	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516000383	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
451516000384	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
451516000385	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
451516000386	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
451516000387	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
451516000388	metal binding site [ion binding]; metal-binding site
451516000389	dimer interface [polypeptide binding]; other site
451516000390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516000391	Major Facilitator Superfamily; Region: MFS_1; pfam07690
451516000392	putative substrate translocation pore; other site
451516000393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516000394	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
451516000395	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
451516000396	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
451516000397	PhoU domain; Region: PhoU; pfam01895
451516000398	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
451516000399	EamA-like transporter family; Region: EamA; pfam00892
451516000400	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
451516000401	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
451516000402	DNA-binding site [nucleotide binding]; DNA binding site
451516000403	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
451516000404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516000405	homodimer interface [polypeptide binding]; other site
451516000406	catalytic residue [active]
451516000407	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
451516000408	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
451516000409	L-lactate permease; Region: Lactate_perm; cl00701
451516000410	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516000411	B domain; Region: B; pfam02216
451516000412	B domain; Region: B; pfam02216
451516000413	B domain; Region: B; pfam02216
451516000414	B domain; Region: B; pfam02216
451516000415	B domain; Region: B; pfam02216
451516000416	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
451516000417	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516000418	Transcriptional regulators [Transcription]; Region: MarR; COG1846
451516000419	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516000420	Transcriptional regulators [Transcription]; Region: MarR; COG1846
451516000421	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
451516000422	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516000423	ABC-ATPase subunit  interface; other site
451516000424	dimer interface [polypeptide binding]; other site
451516000425	putative PBP binding regions; other site
451516000426	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
451516000427	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516000428	ABC-ATPase subunit  interface; other site
451516000429	dimer interface [polypeptide binding]; other site
451516000430	putative PBP binding regions; other site
451516000431	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
451516000432	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
451516000433	siderophore binding site; other site
451516000434	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
451516000435	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
451516000436	dimer interface [polypeptide binding]; other site
451516000437	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516000438	catalytic residue [active]
451516000439	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
451516000440	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
451516000441	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
451516000442	IucA / IucC family; Region: IucA_IucC; pfam04183
451516000443	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
451516000444	drug efflux system protein MdtG; Provisional; Region: PRK09874
451516000445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516000446	putative substrate translocation pore; other site
451516000447	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
451516000448	IucA / IucC family; Region: IucA_IucC; pfam04183
451516000449	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
451516000450	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
451516000451	IucA / IucC family; Region: IucA_IucC; pfam04183
451516000452	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
451516000453	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
451516000454	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
451516000455	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
451516000456	dimer interface [polypeptide binding]; other site
451516000457	active site
451516000458	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
451516000459	catalytic residues [active]
451516000460	substrate binding site [chemical binding]; other site
451516000461	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
451516000462	ParB-like nuclease domain; Region: ParBc; pfam02195
451516000463	acetoin reductase; Validated; Region: PRK08643
451516000464	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
451516000465	NAD binding site [chemical binding]; other site
451516000466	homotetramer interface [polypeptide binding]; other site
451516000467	homodimer interface [polypeptide binding]; other site
451516000468	active site
451516000469	substrate binding site [chemical binding]; other site
451516000470	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
451516000471	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
451516000472	NAD(P) binding site [chemical binding]; other site
451516000473	active site
451516000474	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
451516000475	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
451516000476	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
451516000477	putative ADP-binding pocket [chemical binding]; other site
451516000478	O-Antigen Polymerase; Region: Wzy_C; cl04850
451516000479	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
451516000480	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
451516000481	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
451516000482	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
451516000483	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
451516000484	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
451516000485	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
451516000486	DNA-binding site [nucleotide binding]; DNA binding site
451516000487	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
451516000488	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
451516000489	Major Facilitator Superfamily; Region: MFS_1; pfam07690
451516000490	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
451516000491	intersubunit interface [polypeptide binding]; other site
451516000492	active site
451516000493	catalytic residue [active]
451516000494	phosphopentomutase; Provisional; Region: PRK05362
451516000495	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
451516000496	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
451516000497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516000498	dimer interface [polypeptide binding]; other site
451516000499	conserved gate region; other site
451516000500	putative PBP binding loops; other site
451516000501	ABC-ATPase subunit interface; other site
451516000502	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
451516000503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516000504	dimer interface [polypeptide binding]; other site
451516000505	conserved gate region; other site
451516000506	ABC-ATPase subunit interface; other site
451516000507	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
451516000508	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
451516000509	Walker A/P-loop; other site
451516000510	ATP binding site [chemical binding]; other site
451516000511	Q-loop/lid; other site
451516000512	ABC transporter signature motif; other site
451516000513	Walker B; other site
451516000514	D-loop; other site
451516000515	H-loop/switch region; other site
451516000516	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
451516000517	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
451516000518	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
451516000519	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
451516000520	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
451516000521	active site
451516000522	metal binding site [ion binding]; metal-binding site
451516000523	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
451516000524	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
451516000525	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
451516000526	putative catalytic cysteine [active]
451516000527	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
451516000528	putative active site [active]
451516000529	metal binding site [ion binding]; metal-binding site
451516000530	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
451516000531	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
451516000532	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
451516000533	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
451516000534	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
451516000535	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
451516000536	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
451516000537	NAD(P) binding site [chemical binding]; other site
451516000538	homodimer interface [polypeptide binding]; other site
451516000539	substrate binding site [chemical binding]; other site
451516000540	active site
451516000541	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
451516000542	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
451516000543	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
451516000544	putative NAD(P) binding site [chemical binding]; other site
451516000545	active site
451516000546	putative substrate binding site [chemical binding]; other site
451516000547	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
451516000548	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
451516000549	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
451516000550	trimer interface [polypeptide binding]; other site
451516000551	active site
451516000552	substrate binding site [chemical binding]; other site
451516000553	CoA binding site [chemical binding]; other site
451516000554	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
451516000555	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
451516000556	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
451516000557	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
451516000558	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
451516000559	Bacterial sugar transferase; Region: Bac_transf; pfam02397
451516000560	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
451516000561	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
451516000562	putative NAD(P) binding site [chemical binding]; other site
451516000563	active site
451516000564	putative substrate binding site [chemical binding]; other site
451516000565	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
451516000566	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
451516000567	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
451516000568	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
451516000569	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
451516000570	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
451516000571	active site
451516000572	homodimer interface [polypeptide binding]; other site
451516000573	heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313
451516000574	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
451516000575	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
451516000576	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
451516000577	NAD(P) binding site [chemical binding]; other site
451516000578	catalytic residues [active]
451516000579	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
451516000580	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
451516000581	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
451516000582	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
451516000583	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
451516000584	Walker A/P-loop; other site
451516000585	ATP binding site [chemical binding]; other site
451516000586	Q-loop/lid; other site
451516000587	ABC transporter signature motif; other site
451516000588	Walker B; other site
451516000589	D-loop; other site
451516000590	H-loop/switch region; other site
451516000591	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
451516000592	NMT1-like family; Region: NMT1_2; pfam13379
451516000593	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
451516000594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
451516000595	Uncharacterized conserved protein [Function unknown]; Region: COG5609
451516000596	formate dehydrogenase; Provisional; Region: PRK07574
451516000597	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
451516000598	dimerization interface [polypeptide binding]; other site
451516000599	ligand binding site [chemical binding]; other site
451516000600	NAD binding site [chemical binding]; other site
451516000601	catalytic site [active]
451516000602	putative transporter; Provisional; Region: PRK10054
451516000603	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
451516000604	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
451516000605	acyl-activating enzyme (AAE) consensus motif; other site
451516000606	AMP binding site [chemical binding]; other site
451516000607	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
451516000608	Condensation domain; Region: Condensation; pfam00668
451516000609	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
451516000610	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
451516000611	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
451516000612	acyl-activating enzyme (AAE) consensus motif; other site
451516000613	AMP binding site [chemical binding]; other site
451516000614	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
451516000615	thioester reductase domain; Region: Thioester-redct; TIGR01746
451516000616	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
451516000617	NAD(P) binding site [chemical binding]; other site
451516000618	active site
451516000619	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
451516000620	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
451516000621	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477
451516000622	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
451516000623	nucleotide binding site [chemical binding]; other site
451516000624	N-acetyl-L-glutamate binding site [chemical binding]; other site
451516000625	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
451516000626	heterotetramer interface [polypeptide binding]; other site
451516000627	active site pocket [active]
451516000628	cleavage site
451516000629	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
451516000630	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
451516000631	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
451516000632	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
451516000633	inhibitor-cofactor binding pocket; inhibition site
451516000634	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516000635	catalytic residue [active]
451516000636	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
451516000637	Isochorismatase family; Region: Isochorismatase; pfam00857
451516000638	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
451516000639	catalytic triad [active]
451516000640	conserved cis-peptide bond; other site
451516000641	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
451516000642	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
451516000643	dimer interface [polypeptide binding]; other site
451516000644	PYR/PP interface [polypeptide binding]; other site
451516000645	TPP binding site [chemical binding]; other site
451516000646	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
451516000647	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
451516000648	TPP-binding site [chemical binding]; other site
451516000649	dimer interface [polypeptide binding]; other site
451516000650	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
451516000651	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
451516000652	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
451516000653	active site turn [active]
451516000654	phosphorylation site [posttranslational modification]
451516000655	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
451516000656	HPr interaction site; other site
451516000657	glycerol kinase (GK) interaction site [polypeptide binding]; other site
451516000658	active site
451516000659	phosphorylation site [posttranslational modification]
451516000660	Uncharacterized conserved protein [Function unknown]; Region: COG3589
451516000661	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
451516000662	Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103
451516000663	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
451516000664	putative active site [active]
451516000665	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
451516000666	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
451516000667	active site turn [active]
451516000668	phosphorylation site [posttranslational modification]
451516000669	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
451516000670	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
451516000671	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
451516000672	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
451516000673	putative active site [active]
451516000674	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
451516000675	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
451516000676	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516000677	ATP binding site [chemical binding]; other site
451516000678	putative Mg++ binding site [ion binding]; other site
451516000679	RES domain; Region: RES; pfam08808
451516000680	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
451516000681	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516000682	Walker A/P-loop; other site
451516000683	ATP binding site [chemical binding]; other site
451516000684	Q-loop/lid; other site
451516000685	ABC transporter signature motif; other site
451516000686	Walker B; other site
451516000687	D-loop; other site
451516000688	H-loop/switch region; other site
451516000689	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
451516000690	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516000691	Walker A/P-loop; other site
451516000692	ATP binding site [chemical binding]; other site
451516000693	Q-loop/lid; other site
451516000694	ABC transporter signature motif; other site
451516000695	Walker B; other site
451516000696	D-loop; other site
451516000697	H-loop/switch region; other site
451516000698	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
451516000699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516000700	dimer interface [polypeptide binding]; other site
451516000701	conserved gate region; other site
451516000702	putative PBP binding loops; other site
451516000703	ABC-ATPase subunit interface; other site
451516000704	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
451516000705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516000706	dimer interface [polypeptide binding]; other site
451516000707	conserved gate region; other site
451516000708	ABC-ATPase subunit interface; other site
451516000709	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
451516000710	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
451516000711	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
451516000712	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
451516000713	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
451516000714	Protein of unknown function, DUF576; Region: DUF576; cl04553
451516000715	azoreductase; Reviewed; Region: PRK00170
451516000716	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
451516000717	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
451516000718	Peptidase family M23; Region: Peptidase_M23; pfam01551
451516000719	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
451516000720	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
451516000721	Walker A/P-loop; other site
451516000722	ATP binding site [chemical binding]; other site
451516000723	Q-loop/lid; other site
451516000724	ABC transporter signature motif; other site
451516000725	Walker B; other site
451516000726	D-loop; other site
451516000727	H-loop/switch region; other site
451516000728	TOBE domain; Region: TOBE; pfam03459
451516000729	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
451516000730	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
451516000731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516000732	dimer interface [polypeptide binding]; other site
451516000733	conserved gate region; other site
451516000734	ABC-ATPase subunit interface; other site
451516000735	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
451516000736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516000737	dimer interface [polypeptide binding]; other site
451516000738	conserved gate region; other site
451516000739	putative PBP binding loops; other site
451516000740	ABC-ATPase subunit interface; other site
451516000741	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
451516000742	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
451516000743	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
451516000744	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
451516000745	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
451516000746	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
451516000747	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
451516000748	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
451516000749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
451516000750	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
451516000751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516000752	putative substrate translocation pore; other site
451516000753	Response regulator receiver domain; Region: Response_reg; pfam00072
451516000754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516000755	active site
451516000756	phosphorylation site [posttranslational modification]
451516000757	intermolecular recognition site; other site
451516000758	dimerization interface [polypeptide binding]; other site
451516000759	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
451516000760	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
451516000761	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
451516000762	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
451516000763	Histidine kinase; Region: His_kinase; pfam06580
451516000764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516000765	ATP binding site [chemical binding]; other site
451516000766	Mg2+ binding site [ion binding]; other site
451516000767	G-X-G motif; other site
451516000768	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
451516000769	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
451516000770	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
451516000771	Pyruvate formate lyase 1; Region: PFL1; cd01678
451516000772	coenzyme A binding site [chemical binding]; other site
451516000773	active site
451516000774	catalytic residues [active]
451516000775	glycine loop; other site
451516000776	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
451516000777	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516000778	FeS/SAM binding site; other site
451516000779	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
451516000780	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
451516000781	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
451516000782	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
451516000783	putative active site [active]
451516000784	catalytic site [active]
451516000785	putative metal binding site [ion binding]; other site
451516000786	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
451516000787	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
451516000788	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
451516000789	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
451516000790	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
451516000791	Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022
451516000792	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
451516000793	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
451516000794	dimer interface [polypeptide binding]; other site
451516000795	active site
451516000796	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
451516000797	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
451516000798	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
451516000799	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
451516000800	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
451516000801	substrate binding site [chemical binding]; other site
451516000802	oxyanion hole (OAH) forming residues; other site
451516000803	trimer interface [polypeptide binding]; other site
451516000804	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
451516000805	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
451516000806	active site
451516000807	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
451516000808	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
451516000809	acyl-activating enzyme (AAE) consensus motif; other site
451516000810	AMP binding site [chemical binding]; other site
451516000811	active site
451516000812	CoA binding site [chemical binding]; other site
451516000813	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
451516000814	Coenzyme A transferase; Region: CoA_trans; smart00882
451516000815	Coenzyme A transferase; Region: CoA_trans; cl17247
451516000816	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
451516000817	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
451516000818	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
451516000819	Uncharacterized conserved protein [Function unknown]; Region: COG3189
451516000820	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
451516000821	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
451516000822	heme-binding site [chemical binding]; other site
451516000823	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
451516000824	FAD binding pocket [chemical binding]; other site
451516000825	FAD binding motif [chemical binding]; other site
451516000826	phosphate binding motif [ion binding]; other site
451516000827	beta-alpha-beta structure motif; other site
451516000828	NAD binding pocket [chemical binding]; other site
451516000829	Heme binding  pocket [chemical binding]; other site
451516000830	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
451516000831	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
451516000832	tetramer (dimer of dimers) interface [polypeptide binding]; other site
451516000833	NAD binding site [chemical binding]; other site
451516000834	dimer interface [polypeptide binding]; other site
451516000835	substrate binding site [chemical binding]; other site
451516000836	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
451516000837	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
451516000838	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
451516000839	active site turn [active]
451516000840	phosphorylation site [posttranslational modification]
451516000841	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
451516000842	active site
451516000843	tetramer interface [polypeptide binding]; other site
451516000844	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
451516000845	Mga helix-turn-helix domain; Region: Mga; pfam05043
451516000846	PRD domain; Region: PRD; pfam00874
451516000847	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
451516000848	active site
451516000849	P-loop; other site
451516000850	phosphorylation site [posttranslational modification]
451516000851	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
451516000852	active site
451516000853	phosphorylation site [posttranslational modification]
451516000854	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
451516000855	active site
451516000856	phosphorylation site [posttranslational modification]
451516000857	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
451516000858	active site
451516000859	P-loop; other site
451516000860	phosphorylation site [posttranslational modification]
451516000861	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
451516000862	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
451516000863	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
451516000864	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
451516000865	putative NAD(P) binding site [chemical binding]; other site
451516000866	catalytic Zn binding site [ion binding]; other site
451516000867	structural Zn binding site [ion binding]; other site
451516000868	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
451516000869	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
451516000870	putative NAD(P) binding site [chemical binding]; other site
451516000871	catalytic Zn binding site [ion binding]; other site
451516000872	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
451516000873	substrate binding site; other site
451516000874	dimer interface; other site
451516000875	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
451516000876	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
451516000877	putative NAD(P) binding site [chemical binding]; other site
451516000878	putative catalytic Zn binding site [ion binding]; other site
451516000879	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
451516000880	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
451516000881	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
451516000882	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
451516000883	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
451516000884	substrate binding site; other site
451516000885	dimer interface; other site
451516000886	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
451516000887	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
451516000888	putative NAD(P) binding site [chemical binding]; other site
451516000889	putative catalytic Zn binding site [ion binding]; other site
451516000890	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
451516000891	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
451516000892	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
451516000893	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
451516000894	active site
451516000895	cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276
451516000896	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
451516000897	Hemerythrin-like domain; Region: Hr-like; cd12108
451516000898	Fe binding site [ion binding]; other site
451516000899	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
451516000900	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
451516000901	Histidine kinase; Region: His_kinase; pfam06580
451516000902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516000903	Mg2+ binding site [ion binding]; other site
451516000904	G-X-G motif; other site
451516000905	two-component response regulator; Provisional; Region: PRK14084
451516000906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516000907	active site
451516000908	phosphorylation site [posttranslational modification]
451516000909	intermolecular recognition site; other site
451516000910	dimerization interface [polypeptide binding]; other site
451516000911	LytTr DNA-binding domain; Region: LytTR; pfam04397
451516000912	murein hydrolase regulator LrgA; Provisional; Region: PRK04125
451516000913	antiholin-like protein LrgB; Provisional; Region: PRK04288
451516000914	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
451516000915	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
451516000916	DNA-binding site [nucleotide binding]; DNA binding site
451516000917	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
451516000918	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
451516000919	active site turn [active]
451516000920	phosphorylation site [posttranslational modification]
451516000921	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
451516000922	HPr interaction site; other site
451516000923	glycerol kinase (GK) interaction site [polypeptide binding]; other site
451516000924	active site
451516000925	phosphorylation site [posttranslational modification]
451516000926	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
451516000927	beta-galactosidase; Region: BGL; TIGR03356
451516000928	Methyltransferase domain; Region: Methyltransf_31; pfam13847
451516000929	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516000930	S-adenosylmethionine binding site [chemical binding]; other site
451516000931	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
451516000932	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
451516000933	substrate binding site [chemical binding]; other site
451516000934	dimer interface [polypeptide binding]; other site
451516000935	ATP binding site [chemical binding]; other site
451516000936	D-ribose pyranase; Provisional; Region: PRK11797
451516000937	Sugar transport protein; Region: Sugar_transport; pfam06800
451516000938	Transcriptional regulators [Transcription]; Region: PurR; COG1609
451516000939	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
451516000940	DNA binding site [nucleotide binding]
451516000941	domain linker motif; other site
451516000942	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
451516000943	dimerization interface [polypeptide binding]; other site
451516000944	ligand binding site [chemical binding]; other site
451516000945	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
451516000946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516000947	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516000948	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
451516000949	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
451516000950	active site
451516000951	Surface antigen [General function prediction only]; Region: COG3942
451516000952	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
451516000953	Peptidase family M23; Region: Peptidase_M23; pfam01551
451516000954	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
451516000955	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
451516000956	Walker A/P-loop; other site
451516000957	ATP binding site [chemical binding]; other site
451516000958	Q-loop/lid; other site
451516000959	ABC transporter signature motif; other site
451516000960	Walker B; other site
451516000961	D-loop; other site
451516000962	H-loop/switch region; other site
451516000963	Surface antigen [General function prediction only]; Region: COG3942
451516000964	CHAP domain; Region: CHAP; pfam05257
451516000965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
451516000966	Predicted membrane protein [Function unknown]; Region: COG1511
451516000967	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
451516000968	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
451516000969	type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927
451516000970	Uncharacterized small protein [Function unknown]; Region: COG5417
451516000971	Predicted membrane protein [Function unknown]; Region: COG4499
451516000972	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
451516000973	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
451516000974	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
451516000975	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
451516000976	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
451516000977	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
451516000978	Uncharacterized conserved protein [Function unknown]; Region: COG5444
451516000979	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
451516000980	Protein of unknown function, DUF600; Region: DUF600; cl04640
451516000981	Protein of unknown function, DUF600; Region: DUF600; cl04640
451516000982	Protein of unknown function, DUF600; Region: DUF600; cl04640
451516000983	Protein of unknown function, DUF600; Region: DUF600; cl04640
451516000984	Protein of unknown function, DUF600; Region: DUF600; cl04640
451516000985	Protein of unknown function, DUF600; Region: DUF600; cl04640
451516000986	Protein of unknown function, DUF600; Region: DUF600; cl04640
451516000987	conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741
451516000988	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
451516000989	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
451516000990	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
451516000991	5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533
451516000992	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
451516000993	FtsX-like permease family; Region: FtsX; pfam02687
451516000994	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
451516000995	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
451516000996	Walker A/P-loop; other site
451516000997	ATP binding site [chemical binding]; other site
451516000998	Q-loop/lid; other site
451516000999	ABC transporter signature motif; other site
451516001000	Walker B; other site
451516001001	D-loop; other site
451516001002	H-loop/switch region; other site
451516001003	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
451516001004	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
451516001005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516001006	non-specific DNA binding site [nucleotide binding]; other site
451516001007	salt bridge; other site
451516001008	sequence-specific DNA binding site [nucleotide binding]; other site
451516001009	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
451516001010	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
451516001011	substrate binding site [chemical binding]; other site
451516001012	ATP binding site [chemical binding]; other site
451516001013	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
451516001014	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
451516001015	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
451516001016	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
451516001017	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
451516001018	putative transporter; Provisional; Region: PRK10484
451516001019	Na binding site [ion binding]; other site
451516001020	N-acetylneuraminate lyase; Provisional; Region: PRK04147
451516001021	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
451516001022	inhibitor site; inhibition site
451516001023	active site
451516001024	dimer interface [polypeptide binding]; other site
451516001025	catalytic residue [active]
451516001026	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
451516001027	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
451516001028	nucleotide binding site [chemical binding]; other site
451516001029	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
451516001030	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
451516001031	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
451516001032	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
451516001033	putative active site [active]
451516001034	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
451516001035	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
451516001036	putative active site cavity [active]
451516001037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
451516001038	Nucleoside recognition; Region: Gate; pfam07670
451516001039	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
451516001040	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
451516001041	PGAP1-like protein; Region: PGAP1; pfam07819
451516001042	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
451516001043	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
451516001044	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
451516001045	putative active site [active]
451516001046	putative FMN binding site [chemical binding]; other site
451516001047	putative substrate binding site [chemical binding]; other site
451516001048	putative catalytic residue [active]
451516001049	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
451516001050	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
451516001051	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
451516001052	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
451516001053	lipoyl attachment site [posttranslational modification]; other site
451516001054	Replication protein C N-terminal domain; Region: RP-C; pfam03428
451516001055	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
451516001056	putative ADP-ribose binding site [chemical binding]; other site
451516001057	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
451516001058	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
451516001059	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
451516001060	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
451516001061	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
451516001062	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
451516001063	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
451516001064	NADP binding site [chemical binding]; other site
451516001065	putative substrate binding site [chemical binding]; other site
451516001066	active site
451516001067	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
451516001068	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
451516001069	active site
451516001070	P-loop; other site
451516001071	phosphorylation site [posttranslational modification]
451516001072	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
451516001073	active site
451516001074	phosphorylation site [posttranslational modification]
451516001075	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
451516001076	HTH domain; Region: HTH_11; pfam08279
451516001077	HTH domain; Region: HTH_11; pfam08279
451516001078	PRD domain; Region: PRD; pfam00874
451516001079	PRD domain; Region: PRD; pfam00874
451516001080	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
451516001081	active site
451516001082	P-loop; other site
451516001083	phosphorylation site [posttranslational modification]
451516001084	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
451516001085	active site
451516001086	phosphorylation site [posttranslational modification]
451516001087	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
451516001088	MarR family; Region: MarR_2; pfam12802
451516001089	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
451516001090	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
451516001091	MepB protein; Region: MepB; cl01985
451516001092	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
451516001093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516001094	putative substrate translocation pore; other site
451516001095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516001096	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
451516001097	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
451516001098	Zn binding site [ion binding]; other site
451516001099	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
451516001100	Zn binding site [ion binding]; other site
451516001101	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
451516001102	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
451516001103	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
451516001104	Predicted flavoprotein [General function prediction only]; Region: COG0431
451516001105	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
451516001106	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
451516001107	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
451516001108	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
451516001109	Imelysin; Region: Peptidase_M75; pfam09375
451516001110	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
451516001111	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
451516001112	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
451516001113	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
451516001114	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
451516001115	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
451516001116	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516001117	non-specific DNA binding site [nucleotide binding]; other site
451516001118	salt bridge; other site
451516001119	sequence-specific DNA binding site [nucleotide binding]; other site
451516001120	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
451516001121	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
451516001122	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
451516001123	Walker A/P-loop; other site
451516001124	ATP binding site [chemical binding]; other site
451516001125	Q-loop/lid; other site
451516001126	ABC transporter signature motif; other site
451516001127	Walker B; other site
451516001128	D-loop; other site
451516001129	H-loop/switch region; other site
451516001130	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
451516001131	Predicted membrane protein [Function unknown]; Region: COG4292
451516001132	putative acyltransferase; Provisional; Region: PRK05790
451516001133	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
451516001134	dimer interface [polypeptide binding]; other site
451516001135	active site
451516001136	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
451516001137	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
451516001138	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371
451516001139	THF binding site; other site
451516001140	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
451516001141	substrate binding site [chemical binding]; other site
451516001142	THF binding site; other site
451516001143	zinc-binding site [ion binding]; other site
451516001144	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
451516001145	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
451516001146	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
451516001147	FAD binding site [chemical binding]; other site
451516001148	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
451516001149	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
451516001150	homodimer interface [polypeptide binding]; other site
451516001151	substrate-cofactor binding pocket; other site
451516001152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516001153	catalytic residue [active]
451516001154	cystathionine gamma-synthase; Reviewed; Region: PRK08247
451516001155	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
451516001156	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
451516001157	catalytic residue [active]
451516001158	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
451516001159	ParB-like nuclease domain; Region: ParB; smart00470
451516001160	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
451516001161	Mechanosensitive ion channel; Region: MS_channel; pfam00924
451516001162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
451516001163	GTP-binding protein YchF; Reviewed; Region: PRK09601
451516001164	YchF GTPase; Region: YchF; cd01900
451516001165	G1 box; other site
451516001166	GTP/Mg2+ binding site [chemical binding]; other site
451516001167	Switch I region; other site
451516001168	G2 box; other site
451516001169	Switch II region; other site
451516001170	G3 box; other site
451516001171	G4 box; other site
451516001172	G5 box; other site
451516001173	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
451516001174	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
451516001175	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
451516001176	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
451516001177	dimer interface [polypeptide binding]; other site
451516001178	ssDNA binding site [nucleotide binding]; other site
451516001179	tetramer (dimer of dimers) interface [polypeptide binding]; other site
451516001180	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
451516001181	Abi-like protein; Region: Abi_2; pfam07751
451516001182	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
451516001184	Predicted membrane protein [Function unknown]; Region: COG3212
451516001185	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
451516001186	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
451516001187	non-specific DNA binding site [nucleotide binding]; other site
451516001188	salt bridge; other site
451516001189	sequence-specific DNA binding site [nucleotide binding]; other site
451516001190	Predicted membrane protein [Function unknown]; Region: COG2261
451516001191	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
451516001192	catalytic core [active]
451516001193	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
451516001194	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
451516001195	catalytic residue [active]
451516001196	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
451516001197	catalytic residues [active]
451516001198	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
451516001199	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516001200	peroxiredoxin; Region: AhpC; TIGR03137
451516001201	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
451516001202	dimer interface [polypeptide binding]; other site
451516001203	decamer (pentamer of dimers) interface [polypeptide binding]; other site
451516001204	catalytic triad [active]
451516001205	peroxidatic and resolving cysteines [active]
451516001206	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
451516001207	dimer interface [polypeptide binding]; other site
451516001208	FMN binding site [chemical binding]; other site
451516001209	NADPH bind site [chemical binding]; other site
451516001210	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
451516001211	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
451516001212	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
451516001213	active site
451516001214	xanthine permease; Region: pbuX; TIGR03173
451516001215	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
451516001216	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
451516001217	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
451516001218	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
451516001219	active site
451516001220	GMP synthase; Reviewed; Region: guaA; PRK00074
451516001221	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
451516001222	AMP/PPi binding site [chemical binding]; other site
451516001223	candidate oxyanion hole; other site
451516001224	catalytic triad [active]
451516001225	potential glutamine specificity residues [chemical binding]; other site
451516001226	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
451516001227	ATP Binding subdomain [chemical binding]; other site
451516001228	Ligand Binding sites [chemical binding]; other site
451516001229	Dimerization subdomain; other site
451516001230	PemK-like protein; Region: PemK; pfam02452
451516001231	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
451516001232	Transposase; Region: HTH_Tnp_1; cl17663
451516001233	Predicted membrane protein [Function unknown]; Region: COG3759
451516001234	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
451516001235	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
451516001236	NADP binding site [chemical binding]; other site
451516001237	superantigen-like protein; Reviewed; Region: PRK13037
451516001238	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001239	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001240	superantigen-like protein; Reviewed; Region: PRK13041
451516001241	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001242	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001243	superantigen-like protein; Reviewed; Region: PRK13335
451516001244	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001245	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001246	superantigen-like protein; Reviewed; Region: PRK13042
451516001247	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001248	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001249	superantigen-like protein 5; Reviewed; Region: PRK13035
451516001250	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001251	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001252	superantigen-like protein; Reviewed; Region: PRK13040
451516001253	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001254	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001255	superantigen-like protein 7; Reviewed; Region: PRK13346
451516001256	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001257	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001258	superantigen-like protein; Reviewed; Region: PRK13039
451516001259	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001260	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001261	superantigen-like protein; Reviewed; Region: PRK13345
451516001262	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001263	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001264	superantigen-like protein 5; Reviewed; Region: PRK13035
451516001265	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001266	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001267	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
451516001268	HsdM N-terminal domain; Region: HsdM_N; pfam12161
451516001269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516001270	S-adenosylmethionine binding site [chemical binding]; other site
451516001271	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
451516001272	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
451516001273	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
451516001274	superantigen-like protein; Reviewed; Region: PRK13036
451516001275	Domain of unknown function (DUF1954); Region: DUF1954; pfam09199
451516001276	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516001277	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
451516001278	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516001279	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516001280	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516001281	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516001282	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516001283	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516001284	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516001285	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516001286	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516001287	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
451516001288	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
451516001289	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
451516001290	similar to hypothetical protein
451516001291	similar to hypothetical protein
451516001292	NADH dehydrogenase subunit 5; Validated; Region: PRK08601
451516001293	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
451516001294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
451516001295	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
451516001296	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
451516001297	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
451516001298	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
451516001299	active site
451516001300	Esterase/lipase [General function prediction only]; Region: COG1647
451516001301	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
451516001302	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
451516001303	LysM domain; Region: LysM; pfam01476
451516001304	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
451516001305	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
451516001306	Surface antigen [General function prediction only]; Region: COG3942
451516001307	CHAP domain; Region: CHAP; pfam05257
451516001308	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
451516001309	nudix motif; other site
451516001310	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516001311	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
451516001312	Coenzyme A binding pocket [chemical binding]; other site
451516001313	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
451516001314	Predicted multitransmembrane protein [Function unknown]; Region: COG5438
451516001315	Transcriptional regulator [Transcription]; Region: LysR; COG0583
451516001316	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
451516001317	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
451516001318	dimerization interface [polypeptide binding]; other site
451516001319	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
451516001320	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
451516001321	active site
451516001322	dimer interface [polypeptide binding]; other site
451516001323	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
451516001324	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
451516001325	active site
451516001326	FMN binding site [chemical binding]; other site
451516001327	substrate binding site [chemical binding]; other site
451516001328	3Fe-4S cluster binding site [ion binding]; other site
451516001329	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
451516001330	domain interface; other site
451516001331	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
451516001332	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
451516001333	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
451516001334	active site turn [active]
451516001335	phosphorylation site [posttranslational modification]
451516001336	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
451516001337	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
451516001338	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
451516001339	Ca binding site [ion binding]; other site
451516001340	active site
451516001341	catalytic site [active]
451516001342	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
451516001343	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
451516001344	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516001345	Coenzyme A binding pocket [chemical binding]; other site
451516001346	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
451516001347	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516001348	Walker A motif; other site
451516001349	ATP binding site [chemical binding]; other site
451516001350	Walker B motif; other site
451516001351	arginine finger; other site
451516001352	hypothetical protein; Validated; Region: PRK00153
451516001353	recombination protein RecR; Reviewed; Region: recR; PRK00076
451516001354	RecR protein; Region: RecR; pfam02132
451516001355	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
451516001356	putative active site [active]
451516001357	putative metal-binding site [ion binding]; other site
451516001358	tetramer interface [polypeptide binding]; other site
451516001359	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
451516001360	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
451516001361	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
451516001362	catalytic residue [active]
451516001363	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
451516001364	thymidylate kinase; Validated; Region: tmk; PRK00698
451516001365	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
451516001366	TMP-binding site; other site
451516001367	ATP-binding site [chemical binding]; other site
451516001368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870
451516001369	DNA polymerase III subunit delta'; Validated; Region: PRK08058
451516001370	DNA polymerase III subunit delta'; Validated; Region: PRK08485
451516001371	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
451516001372	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467; cl01853
451516001373	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
451516001374	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516001375	S-adenosylmethionine binding site [chemical binding]; other site
451516001376	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
451516001377	GIY-YIG motif/motif A; other site
451516001378	putative active site [active]
451516001379	putative metal binding site [ion binding]; other site
451516001380	Predicted methyltransferases [General function prediction only]; Region: COG0313
451516001381	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
451516001382	putative SAM binding site [chemical binding]; other site
451516001383	putative homodimer interface [polypeptide binding]; other site
451516001384	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
451516001385	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
451516001386	active site
451516001387	HIGH motif; other site
451516001388	KMSKS motif; other site
451516001389	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
451516001390	tRNA binding surface [nucleotide binding]; other site
451516001391	anticodon binding site; other site
451516001392	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
451516001393	dimer interface [polypeptide binding]; other site
451516001394	putative tRNA-binding site [nucleotide binding]; other site
451516001395	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
451516001396	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
451516001397	active site
451516001398	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
451516001399	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
451516001400	putative active site [active]
451516001401	putative metal binding site [ion binding]; other site
451516001402	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
451516001403	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
451516001404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516001405	S-adenosylmethionine binding site [chemical binding]; other site
451516001406	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
451516001407	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
451516001408	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
451516001409	5S rRNA interface [nucleotide binding]; other site
451516001410	CTC domain interface [polypeptide binding]; other site
451516001411	L16 interface [polypeptide binding]; other site
451516001412	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
451516001413	putative active site [active]
451516001414	catalytic residue [active]
451516001415	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
451516001416	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
451516001417	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516001418	ATP binding site [chemical binding]; other site
451516001419	putative Mg++ binding site [ion binding]; other site
451516001420	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
451516001421	nucleotide binding region [chemical binding]; other site
451516001422	ATP-binding site [chemical binding]; other site
451516001423	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
451516001424	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
451516001425	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
451516001426	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
451516001427	putative SAM binding site [chemical binding]; other site
451516001428	putative homodimer interface [polypeptide binding]; other site
451516001429	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
451516001430	homodimer interface [polypeptide binding]; other site
451516001431	metal binding site [ion binding]; metal-binding site
451516001432	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
451516001433	RNA binding surface [nucleotide binding]; other site
451516001434	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
451516001435	Septum formation initiator; Region: DivIC; pfam04977
451516001436	hypothetical protein; Provisional; Region: PRK08582
451516001437	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
451516001438	RNA binding site [nucleotide binding]; other site
451516001439	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
451516001440	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
451516001441	Ligand Binding Site [chemical binding]; other site
451516001442	TilS substrate C-terminal domain; Region: TilS_C; smart00977
451516001443	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
451516001444	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
451516001445	active site
451516001446	FtsH Extracellular; Region: FtsH_ext; pfam06480
451516001447	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
451516001448	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516001449	Walker A motif; other site
451516001450	ATP binding site [chemical binding]; other site
451516001451	Walker B motif; other site
451516001452	arginine finger; other site
451516001453	Peptidase family M41; Region: Peptidase_M41; pfam01434
451516001454	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
451516001455	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
451516001456	dimerization interface [polypeptide binding]; other site
451516001457	domain crossover interface; other site
451516001458	redox-dependent activation switch; other site
451516001459	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
451516001460	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
451516001461	dimer interface [polypeptide binding]; other site
451516001462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516001463	catalytic residue [active]
451516001464	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
451516001465	dihydropteroate synthase; Region: DHPS; TIGR01496
451516001466	substrate binding pocket [chemical binding]; other site
451516001467	dimer interface [polypeptide binding]; other site
451516001468	inhibitor binding site; inhibition site
451516001469	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
451516001470	homooctamer interface [polypeptide binding]; other site
451516001471	active site
451516001472	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
451516001473	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
451516001474	DNA-binding site [nucleotide binding]; DNA binding site
451516001475	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
451516001476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516001477	homodimer interface [polypeptide binding]; other site
451516001478	catalytic residue [active]
451516001479	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
451516001480	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
451516001481	active site
451516001482	multimer interface [polypeptide binding]; other site
451516001483	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
451516001484	predicted active site [active]
451516001485	catalytic triad [active]
451516001486	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
451516001487	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
451516001488	Nucleoside recognition; Region: Gate; pfam07670
451516001489	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
451516001490	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
451516001491	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
451516001492	UvrB/uvrC motif; Region: UVR; pfam02151
451516001493	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
451516001494	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
451516001495	ADP binding site [chemical binding]; other site
451516001496	phosphagen binding site; other site
451516001497	substrate specificity loop; other site
451516001498	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
451516001499	Clp amino terminal domain; Region: Clp_N; pfam02861
451516001500	Clp amino terminal domain; Region: Clp_N; pfam02861
451516001501	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516001502	Walker A motif; other site
451516001503	ATP binding site [chemical binding]; other site
451516001504	Walker B motif; other site
451516001505	arginine finger; other site
451516001506	UvrB/uvrC motif; Region: UVR; pfam02151
451516001507	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516001508	Walker A motif; other site
451516001509	ATP binding site [chemical binding]; other site
451516001510	Walker B motif; other site
451516001511	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
451516001512	DNA repair protein RadA; Provisional; Region: PRK11823
451516001513	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
451516001514	Walker A motif/ATP binding site; other site
451516001515	ATP binding site [chemical binding]; other site
451516001516	Walker B motif; other site
451516001517	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
451516001518	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
451516001519	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
451516001520	putative active site [active]
451516001521	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
451516001522	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
451516001523	active site
451516001524	HIGH motif; other site
451516001525	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
451516001526	active site
451516001527	KMSKS motif; other site
451516001528	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
451516001529	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
451516001530	trimer interface [polypeptide binding]; other site
451516001531	active site
451516001532	substrate binding site [chemical binding]; other site
451516001533	CoA binding site [chemical binding]; other site
451516001534	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
451516001535	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
451516001536	active site
451516001537	HIGH motif; other site
451516001538	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
451516001539	KMSKS motif; other site
451516001540	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
451516001541	tRNA binding surface [nucleotide binding]; other site
451516001542	anticodon binding site; other site
451516001543	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
451516001544	active site
451516001545	dimerization interface [polypeptide binding]; other site
451516001546	metal binding site [ion binding]; metal-binding site
451516001547	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
451516001548	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
451516001549	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
451516001550	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
451516001551	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
451516001552	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
451516001553	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
451516001554	DNA binding residues [nucleotide binding]
451516001555	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
451516001556	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
451516001557	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
451516001558	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
451516001559	putative homodimer interface [polypeptide binding]; other site
451516001560	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
451516001561	heterodimer interface [polypeptide binding]; other site
451516001562	homodimer interface [polypeptide binding]; other site
451516001563	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
451516001564	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
451516001565	23S rRNA interface [nucleotide binding]; other site
451516001566	L7/L12 interface [polypeptide binding]; other site
451516001567	putative thiostrepton binding site; other site
451516001568	L25 interface [polypeptide binding]; other site
451516001569	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
451516001570	mRNA/rRNA interface [nucleotide binding]; other site
451516001571	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
451516001572	23S rRNA interface [nucleotide binding]; other site
451516001573	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
451516001574	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
451516001575	peripheral dimer interface [polypeptide binding]; other site
451516001576	core dimer interface [polypeptide binding]; other site
451516001577	L10 interface [polypeptide binding]; other site
451516001578	L11 interface [polypeptide binding]; other site
451516001579	putative EF-Tu interaction site [polypeptide binding]; other site
451516001580	putative EF-G interaction site [polypeptide binding]; other site
451516001581	Methyltransferase domain; Region: Methyltransf_31; pfam13847
451516001582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516001583	S-adenosylmethionine binding site [chemical binding]; other site
451516001584	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
451516001585	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
451516001586	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
451516001587	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
451516001588	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
451516001589	RPB10 interaction site [polypeptide binding]; other site
451516001590	RPB1 interaction site [polypeptide binding]; other site
451516001591	RPB11 interaction site [polypeptide binding]; other site
451516001592	RPB3 interaction site [polypeptide binding]; other site
451516001593	RPB12 interaction site [polypeptide binding]; other site
451516001594	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
451516001595	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
451516001596	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
451516001597	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
451516001598	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
451516001599	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
451516001600	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
451516001601	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
451516001602	G-loop; other site
451516001603	DNA binding site [nucleotide binding]
451516001604	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600
451516001605	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
451516001606	S17 interaction site [polypeptide binding]; other site
451516001607	S8 interaction site; other site
451516001608	16S rRNA interaction site [nucleotide binding]; other site
451516001609	streptomycin interaction site [chemical binding]; other site
451516001610	23S rRNA interaction site [nucleotide binding]; other site
451516001611	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
451516001612	30S ribosomal protein S7; Validated; Region: PRK05302
451516001613	elongation factor Tu; Reviewed; Region: PRK00049
451516001614	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
451516001615	G1 box; other site
451516001616	GEF interaction site [polypeptide binding]; other site
451516001617	GTP/Mg2+ binding site [chemical binding]; other site
451516001618	Switch I region; other site
451516001619	G2 box; other site
451516001620	G3 box; other site
451516001621	Switch II region; other site
451516001622	G4 box; other site
451516001623	G5 box; other site
451516001624	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
451516001625	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
451516001626	Antibiotic Binding Site [chemical binding]; other site
451516001627	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
451516001628	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
451516001629	metal binding site [ion binding]; metal-binding site
451516001630	dimer interface [polypeptide binding]; other site
451516001631	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
451516001632	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
451516001633	substrate-cofactor binding pocket; other site
451516001634	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516001635	catalytic residue [active]
451516001636	chaperone protein HchA; Provisional; Region: PRK04155
451516001637	Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148
451516001638	dimer interface [polypeptide binding]; other site
451516001639	metal binding site [ion binding]; metal-binding site
451516001640	potential oxyanion hole; other site
451516001641	potential catalytic triad [active]
451516001642	conserved cys residue [active]
451516001643	ribulokinase; Provisional; Region: PRK04123
451516001644	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
451516001645	N- and C-terminal domain interface [polypeptide binding]; other site
451516001646	active site
451516001647	MgATP binding site [chemical binding]; other site
451516001648	catalytic site [active]
451516001649	metal binding site [ion binding]; metal-binding site
451516001650	carbohydrate binding site [chemical binding]; other site
451516001651	homodimer interface [polypeptide binding]; other site
451516001652	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
451516001653	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
451516001654	NAD(P) binding site [chemical binding]; other site
451516001655	active site
451516001656	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
451516001657	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
451516001658	homodimer interface [polypeptide binding]; other site
451516001659	substrate-cofactor binding pocket; other site
451516001660	catalytic residue [active]
451516001661	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
451516001662	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516001663	motif II; other site
451516001664	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
451516001665	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
451516001666	Substrate-binding site [chemical binding]; other site
451516001667	Substrate specificity [chemical binding]; other site
451516001668	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
451516001669	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
451516001670	Substrate-binding site [chemical binding]; other site
451516001671	Substrate specificity [chemical binding]; other site
451516001672	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
451516001673	nucleoside/Zn binding site; other site
451516001674	dimer interface [polypeptide binding]; other site
451516001675	catalytic motif [active]
451516001676	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516001677	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
451516001678	active site
451516001679	motif I; other site
451516001680	motif II; other site
451516001681	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516001682	Predicted flavoprotein [General function prediction only]; Region: COG0431
451516001683	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
451516001684	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516001685	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
451516001686	Cna protein B-type domain; Region: Cna_B; pfam05738
451516001687	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
451516001688	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516001689	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
451516001690	Cna protein B-type domain; Region: Cna_B; pfam05738
451516001691	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
451516001692	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
451516001693	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
451516001694	Cna protein B-type domain; Region: Cna_B; pfam05738
451516001695	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516001696	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
451516001697	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
451516001698	Cna protein B-type domain; Region: Cna_B; pfam05738
451516001699	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
451516001700	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
451516001701	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
451516001702	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
451516001703	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
451516001704	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
451516001705	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
451516001706	putative GTP cyclohydrolase; Provisional; Region: PRK13674
451516001707	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
451516001708	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
451516001709	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
451516001710	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
451516001711	active site
451516001712	trimer interface [polypeptide binding]; other site
451516001713	allosteric site; other site
451516001714	active site lid [active]
451516001715	hexamer (dimer of trimers) interface [polypeptide binding]; other site
451516001716	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
451516001717	active site
451516001718	dimer interface [polypeptide binding]; other site
451516001719	magnesium binding site [ion binding]; other site
451516001720	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
451516001721	tetramer interface [polypeptide binding]; other site
451516001722	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
451516001723	active site
451516001724	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
451516001725	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516001726	motif II; other site
451516001727	proline/glycine betaine transporter; Provisional; Region: PRK10642
451516001728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516001729	putative substrate translocation pore; other site
451516001730	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
451516001731	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
451516001732	acyl-activating enzyme (AAE) consensus motif; other site
451516001733	AMP binding site [chemical binding]; other site
451516001734	active site
451516001735	CoA binding site [chemical binding]; other site
451516001736	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
451516001737	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
451516001738	dimer interface [polypeptide binding]; other site
451516001739	active site
451516001740	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
451516001741	dimer interface [polypeptide binding]; other site
451516001742	substrate binding site [chemical binding]; other site
451516001743	ATP binding site [chemical binding]; other site
451516001744	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
451516001745	ligand binding site [chemical binding]; other site
451516001746	active site
451516001747	UGI interface [polypeptide binding]; other site
451516001748	catalytic site [active]
451516001749	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
451516001750	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
451516001751	Uncharacterized conserved protein [Function unknown]; Region: COG3610
451516001752	Uncharacterized conserved protein [Function unknown]; Region: COG2966
451516001753	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
451516001754	putative heme peroxidase; Provisional; Region: PRK12276
451516001755	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
451516001756	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
451516001757	mevalonate kinase; Region: mevalon_kin; TIGR00549
451516001758	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
451516001759	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
451516001760	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
451516001761	diphosphomevalonate decarboxylase; Region: PLN02407
451516001762	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
451516001763	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
451516001764	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
451516001765	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
451516001766	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
451516001767	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
451516001768	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516001769	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
451516001770	Predicted transcriptional regulator [Transcription]; Region: COG1959
451516001771	Transcriptional regulator; Region: Rrf2; pfam02082
451516001772	LXG domain of WXG superfamily; Region: LXG; pfam04740
451516001773	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001774	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001775	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001776	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001777	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001778	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001779	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001780	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001781	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001782	Protein of unknown function (DUF443); Region: DUF443; pfam04276
451516001783	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
451516001784	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
451516001785	active site
451516001786	catalytic tetrad [active]
451516001787	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
451516001788	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
451516001789	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
451516001790	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516001791	Coenzyme A binding pocket [chemical binding]; other site
451516001792	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
451516001793	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
451516001794	Zn2+ binding site [ion binding]; other site
451516001795	Mg2+ binding site [ion binding]; other site
451516001796	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
451516001797	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
451516001798	NAD binding site [chemical binding]; other site
451516001799	substrate binding site [chemical binding]; other site
451516001800	catalytic Zn binding site [ion binding]; other site
451516001801	tetramer interface [polypeptide binding]; other site
451516001802	structural Zn binding site [ion binding]; other site
451516001803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
451516001804	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
451516001805	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
451516001806	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
451516001807	active site
451516001808	HIGH motif; other site
451516001809	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
451516001810	KMSK motif region; other site
451516001811	tRNA binding surface [nucleotide binding]; other site
451516001812	DALR anticodon binding domain; Region: DALR_1; smart00836
451516001813	anticodon binding site; other site
451516001814	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
451516001815	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
451516001816	minor groove reading motif; other site
451516001817	helix-hairpin-helix signature motif; other site
451516001818	substrate binding pocket [chemical binding]; other site
451516001819	active site
451516001820	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
451516001821	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
451516001822	putative binding site residues; other site
451516001823	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
451516001824	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516001825	ABC-ATPase subunit  interface; other site
451516001826	dimer interface [polypeptide binding]; other site
451516001827	putative PBP binding regions; other site
451516001828	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
451516001829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516001830	motif II; other site
451516001831	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
451516001832	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
451516001833	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
451516001834	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
451516001835	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516001836	Transcriptional regulators [Transcription]; Region: MarR; COG1846
451516001837	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
451516001838	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
451516001839	Surface antigen [General function prediction only]; Region: COG3942
451516001840	CHAP domain; Region: CHAP; pfam05257
451516001841	ribonuclease E; Reviewed; Region: rne; PRK10811
451516001842	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
451516001843	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
451516001844	AAA-like domain; Region: AAA_10; pfam12846
451516001845	TcpE family; Region: TcpE; pfam12648
451516001846	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
451516001847	Replication initiation factor; Region: Rep_trans; pfam02486
451516001848	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
451516001849	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
451516001850	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
451516001851	active site
451516001852	DNA binding site [nucleotide binding]
451516001853	Int/Topo IB signature motif; other site
451516001854	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646
451516001855	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
451516001856	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
451516001857	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574
451516001858	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660
451516001859	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
451516001860	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
451516001861	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
451516001862	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657
451516001863	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586
451516001864	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
451516001865	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
451516001866	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
451516001867	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
451516001868	metal binding site [ion binding]; metal-binding site
451516001869	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
451516001870	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516001871	ABC-ATPase subunit  interface; other site
451516001872	dimer interface [polypeptide binding]; other site
451516001873	putative PBP binding regions; other site
451516001874	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
451516001875	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
451516001876	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
451516001877	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
451516001878	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
451516001879	FeoA domain; Region: FeoA; pfam04023
451516001880	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
451516001881	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
451516001882	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
451516001883	teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546
451516001884	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
451516001885	Walker A/P-loop; other site
451516001886	ATP binding site [chemical binding]; other site
451516001887	Q-loop/lid; other site
451516001888	ABC transporter signature motif; other site
451516001889	Walker B; other site
451516001890	D-loop; other site
451516001891	H-loop/switch region; other site
451516001892	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
451516001893	ABC-2 type transporter; Region: ABC2_membrane; cl17235
451516001894	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
451516001895	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
451516001896	active site
451516001897	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
451516001898	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
451516001899	active site
451516001900	nucleotide binding site [chemical binding]; other site
451516001901	HIGH motif; other site
451516001902	KMSKS motif; other site
451516001903	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
451516001904	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
451516001905	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
451516001906	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
451516001907	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
451516001908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516001909	Walker A/P-loop; other site
451516001910	ATP binding site [chemical binding]; other site
451516001911	Q-loop/lid; other site
451516001912	ABC transporter signature motif; other site
451516001913	Walker B; other site
451516001914	D-loop; other site
451516001915	H-loop/switch region; other site
451516001916	similar to hypothetical protein
451516001917	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
451516001918	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
451516001919	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
451516001920	Uncharacterized conserved protein [Function unknown]; Region: COG1284
451516001921	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
451516001922	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
451516001923	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
451516001924	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
451516001925	Walker A/P-loop; other site
451516001926	ATP binding site [chemical binding]; other site
451516001927	Q-loop/lid; other site
451516001928	ABC transporter signature motif; other site
451516001929	Walker B; other site
451516001930	D-loop; other site
451516001931	H-loop/switch region; other site
451516001932	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
451516001933	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516001934	ABC-ATPase subunit  interface; other site
451516001935	dimer interface [polypeptide binding]; other site
451516001936	putative PBP binding regions; other site
451516001937	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
451516001938	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516001939	ABC-ATPase subunit  interface; other site
451516001940	dimer interface [polypeptide binding]; other site
451516001941	putative PBP binding regions; other site
451516001942	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
451516001943	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
451516001944	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
451516001945	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
451516001946	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
451516001947	Uncharacterized membrane protein [Function unknown]; Region: COG3949
451516001948	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
451516001949	Na binding site [ion binding]; other site
451516001950	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
451516001951	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
451516001952	substrate binding pocket [chemical binding]; other site
451516001953	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
451516001954	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
451516001955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516001956	Coenzyme A binding pocket [chemical binding]; other site
451516001957	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
451516001958	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
451516001959	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
451516001960	NAD(P) binding site [chemical binding]; other site
451516001961	active site
451516001962	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
451516001963	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516001964	active site
451516001965	phosphorylation site [posttranslational modification]
451516001966	intermolecular recognition site; other site
451516001967	dimerization interface [polypeptide binding]; other site
451516001968	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
451516001969	DNA binding site [nucleotide binding]
451516001970	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
451516001971	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
451516001972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516001973	ATP binding site [chemical binding]; other site
451516001974	Mg2+ binding site [ion binding]; other site
451516001975	G-X-G motif; other site
451516001976	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
451516001977	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
451516001978	Walker A/P-loop; other site
451516001979	ATP binding site [chemical binding]; other site
451516001980	Q-loop/lid; other site
451516001981	ABC transporter signature motif; other site
451516001982	Walker B; other site
451516001983	D-loop; other site
451516001984	H-loop/switch region; other site
451516001985	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
451516001986	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
451516001987	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
451516001988	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
451516001989	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
451516001990	Surface antigen [General function prediction only]; Region: COG3942
451516001991	CHAP domain; Region: CHAP; pfam05257
451516001992	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
451516001993	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
451516001994	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516001995	hypothetical protein; Provisional; Region: PRK12378
451516001996	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
451516001997	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
451516001998	Transcriptional regulator [Transcription]; Region: LysR; COG0583
451516001999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
451516002000	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
451516002001	dimerization interface [polypeptide binding]; other site
451516002002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516002003	sugar efflux transporter; Region: 2A0120; TIGR00899
451516002004	putative substrate translocation pore; other site
451516002005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
451516002006	Serine incorporator (Serinc); Region: Serinc; pfam03348
451516002007	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516002008	Coenzyme A binding pocket [chemical binding]; other site
451516002009	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
451516002010	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
451516002011	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
451516002012	hypothetical protein; Validated; Region: PRK00124
451516002013	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
451516002014	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
451516002015	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
451516002016	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
451516002017	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
451516002018	Walker A/P-loop; other site
451516002019	ATP binding site [chemical binding]; other site
451516002020	Q-loop/lid; other site
451516002021	ABC transporter signature motif; other site
451516002022	Walker B; other site
451516002023	D-loop; other site
451516002024	H-loop/switch region; other site
451516002025	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
451516002026	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
451516002027	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
451516002028	Walker A/P-loop; other site
451516002029	ATP binding site [chemical binding]; other site
451516002030	Q-loop/lid; other site
451516002031	ABC transporter signature motif; other site
451516002032	Walker B; other site
451516002033	D-loop; other site
451516002034	H-loop/switch region; other site
451516002035	Transcriptional regulators [Transcription]; Region: MarR; COG1846
451516002036	MarR family; Region: MarR; pfam01047
451516002037	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
451516002038	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
451516002039	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
451516002040	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
451516002041	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
451516002042	active site
451516002043	catalytic tetrad [active]
451516002044	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
451516002045	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
451516002046	transmembrane helices; other site
451516002047	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
451516002048	DNA photolyase; Region: DNA_photolyase; pfam00875
451516002049	Predicted membrane protein [Function unknown]; Region: COG4330
451516002050	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
451516002051	trimer interface [polypeptide binding]; other site
451516002052	putative Zn binding site [ion binding]; other site
451516002053	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
451516002054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516002055	putative substrate translocation pore; other site
451516002056	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
451516002057	putative deacylase active site [active]
451516002058	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
451516002059	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
451516002060	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
451516002061	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
451516002062	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
451516002063	putative substrate binding site [chemical binding]; other site
451516002064	putative ATP binding site [chemical binding]; other site
451516002065	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
451516002066	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
451516002067	active site
451516002068	phosphorylation site [posttranslational modification]
451516002069	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
451516002070	active site
451516002071	P-loop; other site
451516002072	phosphorylation site [posttranslational modification]
451516002073	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
451516002074	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
451516002075	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
451516002076	active site
451516002077	dimer interface [polypeptide binding]; other site
451516002078	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
451516002079	Domain of unknown function DUF21; Region: DUF21; pfam01595
451516002080	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
451516002081	Transporter associated domain; Region: CorC_HlyC; pfam03471
451516002082	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
451516002083	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
451516002084	active site
451516002085	catalytic tetrad [active]
451516002086	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
451516002087	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
451516002088	Ligand binding site; other site
451516002089	Putative Catalytic site; other site
451516002090	DXD motif; other site
451516002091	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
451516002092	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
451516002093	dimer interface [polypeptide binding]; other site
451516002094	phosphorylation site [posttranslational modification]
451516002095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516002096	ATP binding site [chemical binding]; other site
451516002097	Mg2+ binding site [ion binding]; other site
451516002098	G-X-G motif; other site
451516002099	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
451516002100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516002101	active site
451516002102	phosphorylation site [posttranslational modification]
451516002103	intermolecular recognition site; other site
451516002104	dimerization interface [polypeptide binding]; other site
451516002105	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
451516002106	DNA binding site [nucleotide binding]
451516002107	DoxX; Region: DoxX; pfam07681
451516002108	Electron transfer DM13; Region: DM13; pfam10517
451516002109	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
451516002110	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
451516002111	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
451516002112	active site
451516002113	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
451516002114	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
451516002115	Ligand Binding Site [chemical binding]; other site
451516002116	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
451516002117	Glutamine amidotransferase class-I; Region: GATase; pfam00117
451516002118	glutamine binding [chemical binding]; other site
451516002119	catalytic triad [active]
451516002120	aminodeoxychorismate synthase; Provisional; Region: PRK07508
451516002121	chorismate binding enzyme; Region: Chorismate_bind; cl10555
451516002122	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
451516002123	substrate-cofactor binding pocket; other site
451516002124	Aminotransferase class IV; Region: Aminotran_4; pfam01063
451516002125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516002126	catalytic residue [active]
451516002127	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
451516002128	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
451516002129	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
451516002130	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
451516002131	Sulfatase; Region: Sulfatase; pfam00884
451516002132	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
451516002133	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
451516002134	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
451516002135	ABC transporter; Region: ABC_tran_2; pfam12848
451516002136	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
451516002137	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
451516002138	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516002139	ATP binding site [chemical binding]; other site
451516002140	putative Mg++ binding site [ion binding]; other site
451516002141	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
451516002142	nucleotide binding region [chemical binding]; other site
451516002143	ATP-binding site [chemical binding]; other site
451516002144	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
451516002145	HRDC domain; Region: HRDC; pfam00570
451516002146	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
451516002147	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
451516002148	Walker A/P-loop; other site
451516002149	ATP binding site [chemical binding]; other site
451516002150	Q-loop/lid; other site
451516002151	ABC transporter signature motif; other site
451516002152	Walker B; other site
451516002153	D-loop; other site
451516002154	H-loop/switch region; other site
451516002155	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
451516002156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516002157	dimer interface [polypeptide binding]; other site
451516002158	conserved gate region; other site
451516002159	ABC-ATPase subunit interface; other site
451516002160	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
451516002161	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
451516002162	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
451516002163	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
451516002164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516002165	homodimer interface [polypeptide binding]; other site
451516002166	catalytic residue [active]
451516002167	5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502
451516002168	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
451516002169	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
451516002170	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
451516002171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516002172	putative substrate translocation pore; other site
451516002173	POT family; Region: PTR2; cl17359
451516002174	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
451516002175	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
451516002176	Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780
451516002177	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
451516002178	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
451516002179	Class I ribonucleotide reductase; Region: RNR_I; cd01679
451516002180	active site
451516002181	dimer interface [polypeptide binding]; other site
451516002182	catalytic residues [active]
451516002183	effector binding site; other site
451516002184	R2 peptide binding site; other site
451516002185	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
451516002186	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
451516002187	dimer interface [polypeptide binding]; other site
451516002188	putative radical transfer pathway; other site
451516002189	diiron center [ion binding]; other site
451516002190	tyrosyl radical; other site
451516002191	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516002192	ABC-ATPase subunit  interface; other site
451516002193	dimer interface [polypeptide binding]; other site
451516002194	putative PBP binding regions; other site
451516002195	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516002196	ABC-ATPase subunit  interface; other site
451516002197	dimer interface [polypeptide binding]; other site
451516002198	putative PBP binding regions; other site
451516002199	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
451516002200	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
451516002201	Walker A/P-loop; other site
451516002202	ATP binding site [chemical binding]; other site
451516002203	Q-loop/lid; other site
451516002204	ABC transporter signature motif; other site
451516002205	Walker B; other site
451516002206	D-loop; other site
451516002207	H-loop/switch region; other site
451516002208	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
451516002209	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
451516002210	putative ligand binding residues [chemical binding]; other site
451516002211	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
451516002212	CHY zinc finger; Region: zf-CHY; pfam05495
451516002213	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
451516002214	FAD binding domain; Region: FAD_binding_4; pfam01565
451516002215	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
451516002216	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
451516002217	Protein of unknown function (DUF2847); Region: DUF2847; pfam11009
451516002218	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
451516002219	peptidase T; Region: peptidase-T; TIGR01882
451516002220	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
451516002221	metal binding site [ion binding]; metal-binding site
451516002222	dimer interface [polypeptide binding]; other site
451516002223	Uncharacterized conserved protein [Function unknown]; Region: COG3610
451516002224	Uncharacterized conserved protein [Function unknown]; Region: COG2966
451516002225	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
451516002226	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
451516002227	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
451516002228	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
451516002229	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
451516002230	metal binding site [ion binding]; metal-binding site
451516002231	active site
451516002232	I-site; other site
451516002233	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
451516002234	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
451516002235	Mg++ binding site [ion binding]; other site
451516002236	putative catalytic motif [active]
451516002237	substrate binding site [chemical binding]; other site
451516002238	Uncharacterized conserved protein [Function unknown]; Region: COG1739
451516002239	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
451516002240	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
451516002241	EDD domain protein, DegV family; Region: DegV; TIGR00762
451516002242	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
451516002243	DEAD-like helicases superfamily; Region: DEXDc; smart00487
451516002244	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516002245	ATP binding site [chemical binding]; other site
451516002246	putative Mg++ binding site [ion binding]; other site
451516002247	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
451516002248	nucleotide binding region [chemical binding]; other site
451516002249	ATP-binding site [chemical binding]; other site
451516002250	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
451516002251	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
451516002252	active site
451516002253	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
451516002254	30S subunit binding site; other site
451516002255	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
451516002256	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
451516002257	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
451516002258	nucleotide binding region [chemical binding]; other site
451516002259	ATP-binding site [chemical binding]; other site
451516002260	SEC-C motif; Region: SEC-C; pfam02810
451516002261	This domain is found in peptide chain release factors; Region: PCRF; smart00937
451516002262	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
451516002263	RF-1 domain; Region: RF-1; pfam00472
451516002264	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
451516002265	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
451516002266	Surface antigen [General function prediction only]; Region: COG3942
451516002267	CHAP domain; Region: CHAP; pfam05257
451516002268	HD domain; Region: HD_3; cl17350
451516002269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
451516002270	excinuclease ABC subunit B; Provisional; Region: PRK05298
451516002271	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516002272	ATP binding site [chemical binding]; other site
451516002273	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
451516002274	nucleotide binding region [chemical binding]; other site
451516002275	ATP-binding site [chemical binding]; other site
451516002276	Ultra-violet resistance protein B; Region: UvrB; pfam12344
451516002277	UvrB/uvrC motif; Region: UVR; pfam02151
451516002278	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
451516002279	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
451516002280	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
451516002281	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
451516002282	HPr kinase/phosphorylase; Provisional; Region: PRK05428
451516002283	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
451516002284	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
451516002285	Hpr binding site; other site
451516002286	active site
451516002287	homohexamer subunit interaction site [polypeptide binding]; other site
451516002288	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
451516002289	putative acyl transferase; Provisional; Region: PRK10191
451516002290	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
451516002291	trimer interface [polypeptide binding]; other site
451516002292	active site
451516002293	substrate binding site [chemical binding]; other site
451516002294	CoA binding site [chemical binding]; other site
451516002295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
451516002296	binding surface
451516002297	TPR motif; other site
451516002298	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
451516002299	TPR motif; other site
451516002300	binding surface
451516002301	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
451516002302	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
451516002303	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516002304	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
451516002305	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
451516002306	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
451516002307	phosphate binding site [ion binding]; other site
451516002308	dimer interface [polypeptide binding]; other site
451516002309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
451516002310	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
451516002311	Clp protease; Region: CLP_protease; pfam00574
451516002312	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
451516002313	oligomer interface [polypeptide binding]; other site
451516002314	active site residues [active]
451516002315	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
451516002316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
451516002317	NAD(P) binding site [chemical binding]; other site
451516002318	active site
451516002319	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
451516002320	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
451516002321	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
451516002322	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
451516002323	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
451516002324	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
451516002325	Phosphoglycerate kinase; Region: PGK; pfam00162
451516002326	substrate binding site [chemical binding]; other site
451516002327	hinge regions; other site
451516002328	ADP binding site [chemical binding]; other site
451516002329	catalytic site [active]
451516002330	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
451516002331	triosephosphate isomerase; Provisional; Region: PRK14565
451516002332	substrate binding site [chemical binding]; other site
451516002333	dimer interface [polypeptide binding]; other site
451516002334	catalytic triad [active]
451516002335	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
451516002336	phosphoglyceromutase; Provisional; Region: PRK05434
451516002337	enolase; Provisional; Region: eno; PRK00077
451516002338	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
451516002339	dimer interface [polypeptide binding]; other site
451516002340	metal binding site [ion binding]; metal-binding site
451516002341	substrate binding pocket [chemical binding]; other site
451516002342	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
451516002343	Esterase/lipase [General function prediction only]; Region: COG1647
451516002344	Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735
451516002345	ribonuclease R; Region: RNase_R; TIGR02063
451516002346	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
451516002347	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
451516002348	RNB domain; Region: RNB; pfam00773
451516002349	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
451516002350	RNA binding site [nucleotide binding]; other site
451516002351	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
451516002352	SmpB-tmRNA interface; other site
451516002353	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516002354	Coenzyme A binding pocket [chemical binding]; other site
451516002355	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516002356	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
451516002357	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
451516002358	Staphylococcus aureus coagulase; Region: Coagulase; pfam08764
451516002359	Staphylococcal nuclease homologues; Region: SNc; smart00318
451516002360	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
451516002361	Catalytic site; other site
451516002362	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
451516002363	DNA-binding site [nucleotide binding]; DNA binding site
451516002364	RNA-binding motif; other site
451516002365	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
451516002366	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
451516002367	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
451516002368	catalytic core [active]
451516002369	Lysine efflux permease [General function prediction only]; Region: COG1279
451516002370	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
451516002371	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
451516002372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
451516002373	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
451516002374	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
451516002375	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
451516002376	active site
451516002377	catalytic residue [active]
451516002378	dimer interface [polypeptide binding]; other site
451516002379	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
451516002380	putative FMN binding site [chemical binding]; other site
451516002381	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
451516002382	catalytic residues [active]
451516002383	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
451516002384	ArsC family; Region: ArsC; pfam03960
451516002385	putative ArsC-like catalytic residues; other site
451516002386	putative TRX-like catalytic residues [active]
451516002387	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
451516002388	lipoyl attachment site [posttranslational modification]; other site
451516002389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
451516002390	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
451516002391	Protein of unknown function (DUF3125); Region: DUF3125; pfam11323
451516002392	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
451516002393	putative active site [active]
451516002394	putative metal binding site [ion binding]; other site
451516002395	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
451516002396	catalytic residues [active]
451516002397	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
451516002398	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
451516002399	Walker A/P-loop; other site
451516002400	ATP binding site [chemical binding]; other site
451516002401	Q-loop/lid; other site
451516002402	ABC transporter signature motif; other site
451516002403	Walker B; other site
451516002404	D-loop; other site
451516002405	H-loop/switch region; other site
451516002406	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
451516002407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516002408	dimer interface [polypeptide binding]; other site
451516002409	conserved gate region; other site
451516002410	ABC-ATPase subunit interface; other site
451516002411	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
451516002412	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
451516002413	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
451516002414	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
451516002415	Int/Topo IB signature motif; other site
451516002416	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
451516002417	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516002418	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
451516002419	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516002420	Domain of unknown function (DUF955); Region: DUF955; pfam06114
451516002421	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516002422	non-specific DNA binding site [nucleotide binding]; other site
451516002423	salt bridge; other site
451516002424	sequence-specific DNA binding site [nucleotide binding]; other site
451516002425	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516002426	non-specific DNA binding site [nucleotide binding]; other site
451516002427	salt bridge; other site
451516002428	sequence-specific DNA binding site [nucleotide binding]; other site
451516002429	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
451516002430	Protein of unknown function (DUF1474); Region: DUF1474; pfam07342
451516002431	Uncharacterized conserved protein [Function unknown]; Region: COG4983
451516002432	Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943
451516002433	nucleotide binding site [chemical binding]; other site
451516002434	D5 N terminal like; Region: D5_N; smart00885
451516002435	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
451516002436	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
451516002437	Abi-like protein; Region: Abi_2; pfam07751
451516002438	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
451516002439	Predicted membrane protein [Function unknown]; Region: COG2035
451516002440	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
451516002441	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
451516002442	Walker A/P-loop; other site
451516002443	ATP binding site [chemical binding]; other site
451516002444	Q-loop/lid; other site
451516002445	ABC transporter signature motif; other site
451516002446	Walker B; other site
451516002447	D-loop; other site
451516002448	H-loop/switch region; other site
451516002449	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
451516002450	FeS assembly protein SufD; Region: sufD; TIGR01981
451516002451	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
451516002452	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
451516002453	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
451516002454	catalytic residue [active]
451516002455	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
451516002456	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
451516002457	trimerization site [polypeptide binding]; other site
451516002458	active site
451516002459	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
451516002460	FeS assembly protein SufB; Region: sufB; TIGR01980
451516002461	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
451516002462	Domain of unknown function DUF21; Region: DUF21; pfam01595
451516002463	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
451516002464	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
451516002465	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
451516002466	FMN binding site [chemical binding]; other site
451516002467	substrate binding site [chemical binding]; other site
451516002468	putative catalytic residue [active]
451516002469	Uncharacterized conserved protein [Function unknown]; Region: COG1801
451516002470	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
451516002471	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
451516002472	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
451516002473	active site
451516002474	metal binding site [ion binding]; metal-binding site
451516002475	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
451516002476	lipoyl synthase; Provisional; Region: PRK05481
451516002477	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516002478	FeS/SAM binding site; other site
451516002479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
451516002480	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
451516002481	Uncharacterized conserved protein [Function unknown]; Region: COG2445
451516002482	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
451516002483	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516002484	active site
451516002485	motif I; other site
451516002486	motif II; other site
451516002487	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516002488	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
451516002489	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
451516002490	dimerization interface [polypeptide binding]; other site
451516002491	ligand binding site [chemical binding]; other site
451516002492	NADP binding site [chemical binding]; other site
451516002493	catalytic site [active]
451516002494	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
451516002495	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
451516002496	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
451516002497	acyl-activating enzyme (AAE) consensus motif; other site
451516002498	AMP binding site [chemical binding]; other site
451516002499	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
451516002500	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
451516002501	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
451516002502	DltD N-terminal region; Region: DltD_N; pfam04915
451516002503	DltD central region; Region: DltD_M; pfam04918
451516002504	DltD C-terminal region; Region: DltD_C; pfam04914
451516002505	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
451516002506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
451516002507	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
451516002508	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516002509	hypothetical protein; Provisional; Region: PRK13669
451516002510	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
451516002511	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
451516002512	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516002513	Predicted permease [General function prediction only]; Region: COG2056
451516002514	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
451516002515	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
451516002516	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
451516002517	CoenzymeA binding site [chemical binding]; other site
451516002518	subunit interaction site [polypeptide binding]; other site
451516002519	PHB binding site; other site
451516002520	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
451516002521	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
451516002522	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587
451516002523	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
451516002524	Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942
451516002525	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
451516002526	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
451516002527	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
451516002528	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
451516002529	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
451516002530	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
451516002531	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
451516002532	Kinase associated protein B; Region: KapB; pfam08810
451516002533	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
451516002534	active site
451516002535	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
451516002536	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
451516002537	putative active site [active]
451516002538	putative FMN binding site [chemical binding]; other site
451516002539	putative substrate binding site [chemical binding]; other site
451516002540	putative catalytic residue [active]
451516002541	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
451516002542	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
451516002543	inhibitor-cofactor binding pocket; inhibition site
451516002544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516002545	catalytic residue [active]
451516002546	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
451516002547	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
451516002548	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
451516002549	NAD(P) binding site [chemical binding]; other site
451516002550	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
451516002551	Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601
451516002552	active site
451516002553	catalytic site [active]
451516002554	metal binding site [ion binding]; metal-binding site
451516002555	argininosuccinate lyase; Provisional; Region: PRK00855
451516002556	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
451516002557	active sites [active]
451516002558	tetramer interface [polypeptide binding]; other site
451516002559	argininosuccinate synthase; Provisional; Region: PRK13820
451516002560	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
451516002561	ANP binding site [chemical binding]; other site
451516002562	Substrate Binding Site II [chemical binding]; other site
451516002563	Substrate Binding Site I [chemical binding]; other site
451516002564	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
451516002565	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
451516002566	dimer interface [polypeptide binding]; other site
451516002567	active site
451516002568	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
451516002569	dimer interface [polypeptide binding]; other site
451516002570	active site
451516002571	Uncharacterized conserved protein [Function unknown]; Region: COG0398
451516002572	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
451516002573	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
451516002574	Catalytic site [active]
451516002575	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
451516002576	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
451516002577	Catalytic site [active]
451516002578	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
451516002579	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
451516002580	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
451516002581	Part of AAA domain; Region: AAA_19; pfam13245
451516002582	Family description; Region: UvrD_C_2; pfam13538
451516002583	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
451516002584	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
451516002585	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
451516002586	hypothetical protein; Provisional; Region: PRK13673
451516002587	coenzyme A disulfide reductase; Provisional; Region: PRK13512
451516002588	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
451516002589	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516002590	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
451516002591	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
451516002592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516002593	active site
451516002594	motif I; other site
451516002595	motif II; other site
451516002596	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516002597	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
451516002598	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
451516002599	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
451516002600	catalytic triad [active]
451516002601	catalytic triad [active]
451516002602	oxyanion hole [active]
451516002603	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
451516002604	Clp amino terminal domain; Region: Clp_N; pfam02861
451516002605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516002606	Walker A motif; other site
451516002607	ATP binding site [chemical binding]; other site
451516002608	Walker B motif; other site
451516002609	arginine finger; other site
451516002610	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
451516002611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516002612	Walker A motif; other site
451516002613	ATP binding site [chemical binding]; other site
451516002614	Walker B motif; other site
451516002615	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
451516002616	Transcriptional regulator [Transcription]; Region: LysR; COG0583
451516002617	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
451516002618	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
451516002619	dimerization interface [polypeptide binding]; other site
451516002620	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
451516002621	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
451516002622	active site
451516002623	catalytic residues [active]
451516002624	metal binding site [ion binding]; metal-binding site
451516002625	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
451516002626	MAP domain; Region: MAP; pfam03642
451516002627	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
451516002628	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
451516002629	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
451516002630	dimer interface [polypeptide binding]; other site
451516002631	active site
451516002632	CoA binding pocket [chemical binding]; other site
451516002633	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
451516002634	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
451516002635	dimer interface [polypeptide binding]; other site
451516002636	active site
451516002637	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
451516002638	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
451516002639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516002640	dimer interface [polypeptide binding]; other site
451516002641	conserved gate region; other site
451516002642	putative PBP binding loops; other site
451516002643	ABC-ATPase subunit interface; other site
451516002644	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
451516002645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516002646	dimer interface [polypeptide binding]; other site
451516002647	conserved gate region; other site
451516002648	putative PBP binding loops; other site
451516002649	ABC-ATPase subunit interface; other site
451516002650	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
451516002651	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516002652	Walker A/P-loop; other site
451516002653	ATP binding site [chemical binding]; other site
451516002654	Q-loop/lid; other site
451516002655	ABC transporter signature motif; other site
451516002656	Walker B; other site
451516002657	D-loop; other site
451516002658	H-loop/switch region; other site
451516002659	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
451516002660	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
451516002661	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516002662	Walker A/P-loop; other site
451516002663	ATP binding site [chemical binding]; other site
451516002664	Q-loop/lid; other site
451516002665	ABC transporter signature motif; other site
451516002666	Walker B; other site
451516002667	D-loop; other site
451516002668	H-loop/switch region; other site
451516002669	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
451516002670	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
451516002671	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
451516002672	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
451516002673	peptide binding site [polypeptide binding]; other site
451516002674	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
451516002675	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
451516002676	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
451516002677	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516002678	Walker A/P-loop; other site
451516002679	ATP binding site [chemical binding]; other site
451516002680	Q-loop/lid; other site
451516002681	ABC transporter signature motif; other site
451516002682	Walker B; other site
451516002683	D-loop; other site
451516002684	H-loop/switch region; other site
451516002685	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
451516002686	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
451516002687	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516002688	Walker A/P-loop; other site
451516002689	ATP binding site [chemical binding]; other site
451516002690	Q-loop/lid; other site
451516002691	ABC transporter signature motif; other site
451516002692	Walker B; other site
451516002693	D-loop; other site
451516002694	H-loop/switch region; other site
451516002695	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
451516002696	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
451516002697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516002698	dimer interface [polypeptide binding]; other site
451516002699	conserved gate region; other site
451516002700	putative PBP binding loops; other site
451516002701	ABC-ATPase subunit interface; other site
451516002702	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
451516002703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516002704	dimer interface [polypeptide binding]; other site
451516002705	conserved gate region; other site
451516002706	putative PBP binding loops; other site
451516002707	ABC-ATPase subunit interface; other site
451516002708	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
451516002709	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
451516002710	active site
451516002711	HIGH motif; other site
451516002712	dimer interface [polypeptide binding]; other site
451516002713	KMSKS motif; other site
451516002714	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
451516002715	ArsC family; Region: ArsC; pfam03960
451516002716	putative catalytic residues [active]
451516002717	thiol/disulfide switch; other site
451516002718	adaptor protein; Provisional; Region: PRK02315
451516002719	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
451516002720	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
451516002721	active site
451516002722	Zn binding site [ion binding]; other site
451516002723	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
451516002724	Thioredoxin; Region: Thioredoxin_5; pfam13743
451516002725	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
451516002726	apolar tunnel; other site
451516002727	heme binding site [chemical binding]; other site
451516002728	dimerization interface [polypeptide binding]; other site
451516002729	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
451516002730	putative active site [active]
451516002731	putative metal binding residues [ion binding]; other site
451516002732	signature motif; other site
451516002733	putative triphosphate binding site [ion binding]; other site
451516002734	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
451516002735	synthetase active site [active]
451516002736	NTP binding site [chemical binding]; other site
451516002737	metal binding site [ion binding]; metal-binding site
451516002738	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
451516002739	ATP-NAD kinase; Region: NAD_kinase; pfam01513
451516002740	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
451516002741	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
451516002742	active site
451516002743	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
451516002744	MgtE intracellular N domain; Region: MgtE_N; smart00924
451516002745	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
451516002746	Divalent cation transporter; Region: MgtE; pfam01769
451516002747	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
451516002748	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
451516002749	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
451516002750	TrkA-N domain; Region: TrkA_N; pfam02254
451516002751	TrkA-C domain; Region: TrkA_C; pfam02080
451516002752	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
451516002753	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
451516002754	NAD binding site [chemical binding]; other site
451516002755	homotetramer interface [polypeptide binding]; other site
451516002756	homodimer interface [polypeptide binding]; other site
451516002757	substrate binding site [chemical binding]; other site
451516002758	active site
451516002759	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
451516002760	Domain of unknown function DUF20; Region: UPF0118; pfam01594
451516002761	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
451516002762	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
451516002763	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
451516002764	Putative esterase; Region: Esterase; pfam00756
451516002765	hypothetical protein; Provisional; Region: PRK13679
451516002766	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
451516002767	Major Facilitator Superfamily; Region: MFS_1; pfam07690
451516002768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516002769	putative substrate translocation pore; other site
451516002770	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
451516002771	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
451516002772	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
451516002773	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
451516002774	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
451516002775	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
451516002776	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
451516002777	YueH-like protein; Region: YueH; pfam14166
451516002778	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
451516002779	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
451516002780	G1 box; other site
451516002781	putative GEF interaction site [polypeptide binding]; other site
451516002782	GTP/Mg2+ binding site [chemical binding]; other site
451516002783	Switch I region; other site
451516002784	G2 box; other site
451516002785	G3 box; other site
451516002786	Switch II region; other site
451516002787	G4 box; other site
451516002788	G5 box; other site
451516002789	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
451516002790	YybP/YkoY riboswitch; SraF; USA300HOU_nc0005
451516002791	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
451516002792	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
451516002793	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
451516002794	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
451516002795	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
451516002796	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
451516002797	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
451516002798	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
451516002799	active site
451516002800	metal binding site [ion binding]; metal-binding site
451516002801	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
451516002802	Genetic competence transcription factor [Transcription]; Region: ComK; COG4903
451516002803	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
451516002804	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
451516002805	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
451516002806	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
451516002807	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
451516002808	siderophore binding site; other site
451516002809	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
451516002810	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516002811	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
451516002812	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
451516002813	Coenzyme A binding pocket [chemical binding]; other site
451516002814	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
451516002815	UbiA prenyltransferase family; Region: UbiA; pfam01040
451516002816	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
451516002817	isochorismate synthases; Region: isochor_syn; TIGR00543
451516002818	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
451516002819	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
451516002820	dimer interface [polypeptide binding]; other site
451516002821	tetramer interface [polypeptide binding]; other site
451516002822	PYR/PP interface [polypeptide binding]; other site
451516002823	TPP binding site [chemical binding]; other site
451516002824	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
451516002825	TPP-binding site; other site
451516002826	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
451516002827	PGAP1-like protein; Region: PGAP1; pfam07819
451516002828	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
451516002829	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
451516002830	substrate binding site [chemical binding]; other site
451516002831	oxyanion hole (OAH) forming residues; other site
451516002832	trimer interface [polypeptide binding]; other site
451516002833	Staphostatin B; Region: Staphostatin_B; pfam09023
451516002834	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
451516002835	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
451516002836	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
451516002837	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
451516002838	amidase catalytic site [active]
451516002839	Zn binding residues [ion binding]; other site
451516002840	substrate binding site [chemical binding]; other site
451516002841	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
451516002842	Lysozyme subfamily 2; Region: LYZ2; smart00047
451516002843	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516002844	Coenzyme A binding pocket [chemical binding]; other site
451516002845	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
451516002846	Transcriptional regulator [Transcription]; Region: LytR; COG1316
451516002847	Beta-lactamase; Region: Beta-lactamase; pfam00144
451516002848	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
451516002849	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
451516002850	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
451516002851	Subunit I/III interface [polypeptide binding]; other site
451516002852	Subunit III/IV interface [polypeptide binding]; other site
451516002853	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
451516002854	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
451516002855	D-pathway; other site
451516002856	Putative ubiquinol binding site [chemical binding]; other site
451516002857	Low-spin heme (heme b) binding site [chemical binding]; other site
451516002858	Putative water exit pathway; other site
451516002859	Binuclear center (heme o3/CuB) [ion binding]; other site
451516002860	K-pathway; other site
451516002861	Putative proton exit pathway; other site
451516002862	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
451516002863	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
451516002864	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
451516002865	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
451516002866	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175
451516002867	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
451516002868	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
451516002869	homodimer interface [polypeptide binding]; other site
451516002870	NADP binding site [chemical binding]; other site
451516002871	substrate binding site [chemical binding]; other site
451516002872	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
451516002873	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
451516002874	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
451516002875	NAD binding site [chemical binding]; other site
451516002876	ATP-grasp domain; Region: ATP-grasp; pfam02222
451516002877	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
451516002878	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
451516002879	ATP binding site [chemical binding]; other site
451516002880	active site
451516002881	substrate binding site [chemical binding]; other site
451516002882	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
451516002883	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
451516002884	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
451516002885	putative active site [active]
451516002886	catalytic triad [active]
451516002887	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
451516002888	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
451516002889	dimerization interface [polypeptide binding]; other site
451516002890	ATP binding site [chemical binding]; other site
451516002891	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
451516002892	dimerization interface [polypeptide binding]; other site
451516002893	ATP binding site [chemical binding]; other site
451516002894	amidophosphoribosyltransferase; Provisional; Region: PRK07272
451516002895	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
451516002896	active site
451516002897	tetramer interface [polypeptide binding]; other site
451516002898	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
451516002899	active site
451516002900	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
451516002901	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
451516002902	dimerization interface [polypeptide binding]; other site
451516002903	putative ATP binding site [chemical binding]; other site
451516002904	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
451516002905	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
451516002906	purine monophosphate binding site [chemical binding]; other site
451516002907	dimer interface [polypeptide binding]; other site
451516002908	putative catalytic residues [active]
451516002909	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
451516002910	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
451516002911	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
451516002912	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
451516002913	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
451516002914	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
451516002915	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
451516002916	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
451516002917	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
451516002918	Walker A/P-loop; other site
451516002919	ATP binding site [chemical binding]; other site
451516002920	Q-loop/lid; other site
451516002921	ABC transporter signature motif; other site
451516002922	Walker B; other site
451516002923	D-loop; other site
451516002924	H-loop/switch region; other site
451516002925	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
451516002926	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
451516002927	Walker A/P-loop; other site
451516002928	ATP binding site [chemical binding]; other site
451516002929	Q-loop/lid; other site
451516002930	ABC transporter signature motif; other site
451516002931	Walker B; other site
451516002932	D-loop; other site
451516002933	H-loop/switch region; other site
451516002934	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
451516002935	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
451516002936	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
451516002937	putative RNA binding site [nucleotide binding]; other site
451516002938	Methyltransferase domain; Region: Methyltransf_26; pfam13659
451516002939	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
451516002940	dimerization domain swap beta strand [polypeptide binding]; other site
451516002941	regulatory protein interface [polypeptide binding]; other site
451516002942	active site
451516002943	regulatory phosphorylation site [posttranslational modification]; other site
451516002944	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
451516002945	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
451516002946	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
451516002947	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
451516002948	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
451516002949	catalytic residues [active]
451516002950	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
451516002951	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
451516002952	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
451516002953	TrkA-N domain; Region: TrkA_N; pfam02254
451516002954	TrkA-C domain; Region: TrkA_C; pfam02080
451516002955	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
451516002956	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
451516002957	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
451516002958	hypothetical protein; Provisional; Region: PRK13667
451516002959	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
451516002960	active site
451516002961	catalytic residues [active]
451516002962	metal binding site [ion binding]; metal-binding site
451516002963	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
451516002964	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
451516002965	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
451516002966	TPP-binding site [chemical binding]; other site
451516002967	tetramer interface [polypeptide binding]; other site
451516002968	heterodimer interface [polypeptide binding]; other site
451516002969	phosphorylation loop region [posttranslational modification]
451516002970	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
451516002971	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
451516002972	alpha subunit interface [polypeptide binding]; other site
451516002973	TPP binding site [chemical binding]; other site
451516002974	heterodimer interface [polypeptide binding]; other site
451516002975	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
451516002976	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
451516002977	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
451516002978	E3 interaction surface; other site
451516002979	lipoyl attachment site [posttranslational modification]; other site
451516002980	e3 binding domain; Region: E3_binding; pfam02817
451516002981	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
451516002982	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
451516002983	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
451516002984	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516002985	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
451516002986	hypothetical protein; Provisional; Region: PRK04387
451516002987	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
451516002988	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516002989	non-specific DNA binding site [nucleotide binding]; other site
451516002990	salt bridge; other site
451516002991	sequence-specific DNA binding site [nucleotide binding]; other site
451516002992	Cupin domain; Region: Cupin_2; pfam07883
451516002993	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
451516002994	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516002995	Walker A/P-loop; other site
451516002996	ATP binding site [chemical binding]; other site
451516002997	Q-loop/lid; other site
451516002998	ABC transporter signature motif; other site
451516002999	Walker B; other site
451516003000	D-loop; other site
451516003001	H-loop/switch region; other site
451516003002	TOBE domain; Region: TOBE_2; pfam08402
451516003003	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
451516003004	Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955
451516003005	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
451516003006	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
451516003007	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
451516003008	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
451516003009	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
451516003010	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
451516003011	G1 box; other site
451516003012	putative GEF interaction site [polypeptide binding]; other site
451516003013	GTP/Mg2+ binding site [chemical binding]; other site
451516003014	Switch I region; other site
451516003015	G2 box; other site
451516003016	G3 box; other site
451516003017	Switch II region; other site
451516003018	G4 box; other site
451516003019	G5 box; other site
451516003020	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
451516003021	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
451516003022	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963
451516003023	hypothetical protein; Provisional; Region: PRK13666
451516003024	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
451516003025	pyruvate carboxylase; Reviewed; Region: PRK12999
451516003026	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
451516003027	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
451516003028	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
451516003029	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
451516003030	active site
451516003031	catalytic residues [active]
451516003032	metal binding site [ion binding]; metal-binding site
451516003033	homodimer binding site [polypeptide binding]; other site
451516003034	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
451516003035	carboxyltransferase (CT) interaction site; other site
451516003036	biotinylation site [posttranslational modification]; other site
451516003037	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
451516003038	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
451516003039	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
451516003040	UbiA prenyltransferase family; Region: UbiA; pfam01040
451516003041	Predicted membrane protein [Function unknown]; Region: COG2322
451516003042	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
451516003043	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
451516003044	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
451516003045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471
451516003046	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
451516003047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516003048	S-adenosylmethionine binding site [chemical binding]; other site
451516003049	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
451516003050	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
451516003051	active site
451516003052	(T/H)XGH motif; other site
451516003053	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
451516003054	hypothetical protein; Provisional; Region: PRK13670
451516003055	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
451516003056	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
451516003057	heme-binding site [chemical binding]; other site
451516003058	heme uptake protein IsdC; Region: IsdC; TIGR03656
451516003059	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
451516003060	heme-binding site [chemical binding]; other site
451516003061	sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068
451516003062	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
451516003063	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
451516003064	intersubunit interface [polypeptide binding]; other site
451516003065	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
451516003066	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516003067	ABC-ATPase subunit  interface; other site
451516003068	dimer interface [polypeptide binding]; other site
451516003069	putative PBP binding regions; other site
451516003070	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312
451516003071	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
451516003072	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
451516003073	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
451516003074	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
451516003075	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
451516003076	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
451516003077	dimer interface [polypeptide binding]; other site
451516003078	motif 1; other site
451516003079	active site
451516003080	motif 2; other site
451516003081	motif 3; other site
451516003082	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
451516003083	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
451516003084	putative tRNA-binding site [nucleotide binding]; other site
451516003085	B3/4 domain; Region: B3_4; pfam03483
451516003086	tRNA synthetase B5 domain; Region: B5; smart00874
451516003087	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
451516003088	dimer interface [polypeptide binding]; other site
451516003089	motif 1; other site
451516003090	motif 3; other site
451516003091	motif 2; other site
451516003092	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
451516003093	ribonuclease HIII; Provisional; Region: PRK00996
451516003094	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
451516003095	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
451516003096	RNA/DNA hybrid binding site [nucleotide binding]; other site
451516003097	active site
451516003098	Cell division protein ZapA; Region: ZapA; cl01146
451516003099	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
451516003100	Colicin V production protein; Region: Colicin_V; pfam02674
451516003101	hypothetical protein; Provisional; Region: PRK08609
451516003102	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
451516003103	active site
451516003104	primer binding site [nucleotide binding]; other site
451516003105	NTP  binding site [chemical binding]; other site
451516003106	metal binding triad [ion binding]; metal-binding site
451516003107	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
451516003108	active site
451516003109	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
451516003110	MutS domain III; Region: MutS_III; pfam05192
451516003111	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
451516003112	Walker A/P-loop; other site
451516003113	ATP binding site [chemical binding]; other site
451516003114	Q-loop/lid; other site
451516003115	ABC transporter signature motif; other site
451516003116	Walker B; other site
451516003117	D-loop; other site
451516003118	H-loop/switch region; other site
451516003119	Smr domain; Region: Smr; pfam01713
451516003120	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
451516003121	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
451516003122	catalytic residues [active]
451516003123	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
451516003124	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
451516003125	GIY-YIG motif/motif A; other site
451516003126	active site
451516003127	catalytic site [active]
451516003128	putative DNA binding site [nucleotide binding]; other site
451516003129	metal binding site [ion binding]; metal-binding site
451516003130	UvrB/uvrC motif; Region: UVR; pfam02151
451516003131	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
451516003132	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
451516003133	putative Iron-sulfur protein interface [polypeptide binding]; other site
451516003134	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
451516003135	proximal heme binding site [chemical binding]; other site
451516003136	distal heme binding site [chemical binding]; other site
451516003137	putative dimer interface [polypeptide binding]; other site
451516003138	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
451516003139	L-aspartate oxidase; Provisional; Region: PRK06175
451516003140	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
451516003141	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
451516003142	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
451516003143	glutamate racemase; Provisional; Region: PRK00865
451516003144	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
451516003145	active site
451516003146	dimerization interface [polypeptide binding]; other site
451516003147	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
451516003148	active site
451516003149	metal binding site [ion binding]; metal-binding site
451516003150	homotetramer interface [polypeptide binding]; other site
451516003151	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
451516003152	formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033
451516003153	Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199
451516003154	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
451516003155	beta-channel forming cytolysin; Region: hlyII; TIGR01002
451516003156	superantigen-like protein; Reviewed; Region: PRK13350
451516003157	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516003158	superantigen-like protein; Reviewed; Region: PRK13349
451516003159	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516003160	superantigen-like protein; Reviewed; Region: PRK13043
451516003161	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516003162	ornithine carbamoyltransferase; Provisional; Region: PRK04284
451516003163	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
451516003164	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
451516003165	carbamate kinase; Reviewed; Region: PRK12686
451516003166	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
451516003167	putative substrate binding site [chemical binding]; other site
451516003168	nucleotide binding site [chemical binding]; other site
451516003169	nucleotide binding site [chemical binding]; other site
451516003170	homodimer interface [polypeptide binding]; other site
451516003171	Predicted membrane protein [Function unknown]; Region: COG1288
451516003172	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
451516003173	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
451516003174	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
451516003175	gating phenylalanine in ion channel; other site
451516003176	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
451516003177	Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480
451516003178	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
451516003179	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516003180	motif II; other site
451516003181	hypothetical protein; Provisional; Region: PRK13688
451516003182	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
451516003183	Coenzyme A binding pocket [chemical binding]; other site
451516003184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
451516003185	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
451516003186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
451516003187	MraZ protein; Region: MraZ; pfam02381
451516003188	MraZ protein; Region: MraZ; pfam02381
451516003189	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
451516003190	MraW methylase family; Region: Methyltransf_5; pfam01795
451516003191	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
451516003192	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
451516003193	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
451516003194	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
451516003195	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
451516003196	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
451516003197	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
451516003198	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
451516003199	Mg++ binding site [ion binding]; other site
451516003200	putative catalytic motif [active]
451516003201	putative substrate binding site [chemical binding]; other site
451516003202	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
451516003203	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
451516003204	NAD binding site [chemical binding]; other site
451516003205	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
451516003206	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
451516003207	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
451516003208	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
451516003209	Cell division protein FtsQ; Region: FtsQ; pfam03799
451516003210	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
451516003211	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
451516003212	catalytic residue [active]
451516003213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
451516003214	YGGT family; Region: YGGT; pfam02325
451516003215	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
451516003216	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
451516003217	RNA binding surface [nucleotide binding]; other site
451516003218	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
451516003219	DivIVA domain; Region: DivI1A_domain; TIGR03544
451516003220	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
451516003221	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
451516003222	HIGH motif; other site
451516003223	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
451516003224	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
451516003225	active site
451516003226	KMSKS motif; other site
451516003227	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
451516003228	tRNA binding surface [nucleotide binding]; other site
451516003229	anticodon binding site; other site
451516003230	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
451516003231	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
451516003232	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
451516003233	active site
451516003234	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
451516003235	lipoprotein signal peptidase; Provisional; Region: PRK14787
451516003236	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
451516003237	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
451516003238	RNA binding surface [nucleotide binding]; other site
451516003239	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
451516003240	active site
451516003241	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
451516003242	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
451516003243	uracil transporter; Provisional; Region: PRK10720
451516003244	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
451516003245	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
451516003246	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
451516003247	dihydroorotase; Validated; Region: pyrC; PRK09357
451516003248	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
451516003249	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
451516003250	active site
451516003251	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
451516003252	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
451516003253	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
451516003254	catalytic site [active]
451516003255	subunit interface [polypeptide binding]; other site
451516003256	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
451516003257	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
451516003258	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
451516003259	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
451516003260	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
451516003261	ATP-grasp domain; Region: ATP-grasp_4; cl17255
451516003262	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
451516003263	IMP binding site; other site
451516003264	dimer interface [polypeptide binding]; other site
451516003265	interdomain contacts; other site
451516003266	partial ornithine binding site; other site
451516003267	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
451516003268	active site
451516003269	dimer interface [polypeptide binding]; other site
451516003270	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
451516003271	active site
451516003272	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
451516003273	dimer interface [polypeptide binding]; other site
451516003274	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
451516003275	Domain of unknown function (DUF814); Region: DUF814; pfam05670
451516003276	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
451516003277	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
451516003278	catalytic site [active]
451516003279	G-X2-G-X-G-K; other site
451516003280	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
451516003281	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
451516003282	Flavoprotein; Region: Flavoprotein; pfam02441
451516003283	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
451516003284	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
451516003285	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516003286	ATP binding site [chemical binding]; other site
451516003287	putative Mg++ binding site [ion binding]; other site
451516003288	helicase superfamily c-terminal domain; Region: HELICc; smart00490
451516003289	nucleotide binding region [chemical binding]; other site
451516003290	ATP-binding site [chemical binding]; other site
451516003291	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
451516003292	active site
451516003293	catalytic residues [active]
451516003294	metal binding site [ion binding]; metal-binding site
451516003295	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
451516003296	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
451516003297	putative active site [active]
451516003298	substrate binding site [chemical binding]; other site
451516003299	putative cosubstrate binding site; other site
451516003300	catalytic site [active]
451516003301	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
451516003302	substrate binding site [chemical binding]; other site
451516003303	16S rRNA methyltransferase B; Provisional; Region: PRK14902
451516003304	NusB family; Region: NusB; pfam01029
451516003305	putative RNA binding site [nucleotide binding]; other site
451516003306	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516003307	S-adenosylmethionine binding site [chemical binding]; other site
451516003308	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
451516003309	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516003310	FeS/SAM binding site; other site
451516003311	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
451516003312	Protein phosphatase 2C; Region: PP2C; pfam00481
451516003313	active site
451516003314	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
451516003315	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
451516003316	active site
451516003317	ATP binding site [chemical binding]; other site
451516003318	substrate binding site [chemical binding]; other site
451516003319	activation loop (A-loop); other site
451516003320	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
451516003321	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
451516003322	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
451516003323	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
451516003324	Predicted GTPases [General function prediction only]; Region: COG1162
451516003325	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
451516003326	RNA binding site [nucleotide binding]; other site
451516003327	homodimer interface [polypeptide binding]; other site
451516003328	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
451516003329	GTPase/Zn-binding domain interface [polypeptide binding]; other site
451516003330	GTP/Mg2+ binding site [chemical binding]; other site
451516003331	G4 box; other site
451516003332	G5 box; other site
451516003333	G1 box; other site
451516003334	Switch I region; other site
451516003335	G2 box; other site
451516003336	G3 box; other site
451516003337	Switch II region; other site
451516003338	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
451516003339	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
451516003340	substrate binding site [chemical binding]; other site
451516003341	hexamer interface [polypeptide binding]; other site
451516003342	metal binding site [ion binding]; metal-binding site
451516003343	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
451516003344	Thiamine pyrophosphokinase; Region: TPK; cd07995
451516003345	active site
451516003346	dimerization interface [polypeptide binding]; other site
451516003347	thiamine binding site [chemical binding]; other site
451516003348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
451516003349	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
451516003350	DAK2 domain; Region: Dak2; pfam02734
451516003351	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
451516003352	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
451516003353	generic binding surface II; other site
451516003354	ssDNA binding site; other site
451516003355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516003356	ATP binding site [chemical binding]; other site
451516003357	putative Mg++ binding site [ion binding]; other site
451516003358	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
451516003359	nucleotide binding region [chemical binding]; other site
451516003360	ATP-binding site [chemical binding]; other site
451516003361	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
451516003362	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
451516003363	active site 2 [active]
451516003364	active site 1 [active]
451516003365	putative phosphate acyltransferase; Provisional; Region: PRK05331
451516003366	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
451516003367	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
451516003368	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
451516003369	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
451516003370	NAD(P) binding site [chemical binding]; other site
451516003371	homotetramer interface [polypeptide binding]; other site
451516003372	homodimer interface [polypeptide binding]; other site
451516003373	active site
451516003374	acyl carrier protein; Provisional; Region: acpP; PRK00982
451516003375	ribonuclease III; Reviewed; Region: rnc; PRK00102
451516003376	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
451516003377	dimerization interface [polypeptide binding]; other site
451516003378	active site
451516003379	metal binding site [ion binding]; metal-binding site
451516003380	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
451516003381	dsRNA binding site [nucleotide binding]; other site
451516003382	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
451516003383	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
451516003384	Walker A/P-loop; other site
451516003385	ATP binding site [chemical binding]; other site
451516003386	Q-loop/lid; other site
451516003387	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
451516003388	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
451516003389	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
451516003390	ABC transporter signature motif; other site
451516003391	Walker B; other site
451516003392	D-loop; other site
451516003393	H-loop/switch region; other site
451516003394	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
451516003395	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
451516003396	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
451516003397	P loop; other site
451516003398	GTP binding site [chemical binding]; other site
451516003399	Predicted membrane protein [Function unknown]; Region: COG4485
451516003400	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
451516003401	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
451516003402	GTP/Mg2+ binding site [chemical binding]; other site
451516003403	G4 box; other site
451516003404	G5 box; other site
451516003405	G1 box; other site
451516003406	Switch I region; other site
451516003407	G2 box; other site
451516003408	G3 box; other site
451516003409	Switch II region; other site
451516003410	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
451516003411	RNA/DNA hybrid binding site [nucleotide binding]; other site
451516003412	active site
451516003413	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
451516003414	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
451516003415	CoA-ligase; Region: Ligase_CoA; pfam00549
451516003416	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
451516003417	CoA binding domain; Region: CoA_binding; pfam02629
451516003418	CoA-ligase; Region: Ligase_CoA; pfam00549
451516003419	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
451516003420	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
451516003421	CHAP domain; Region: CHAP; pfam05257
451516003422	FemAB family; Region: FemAB; pfam02388
451516003423	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
451516003424	DNA protecting protein DprA; Region: dprA; TIGR00732
451516003425	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
451516003426	DNA topoisomerase I; Validated; Region: PRK05582
451516003427	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
451516003428	active site
451516003429	interdomain interaction site; other site
451516003430	putative metal-binding site [ion binding]; other site
451516003431	nucleotide binding site [chemical binding]; other site
451516003432	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
451516003433	domain I; other site
451516003434	DNA binding groove [nucleotide binding]
451516003435	phosphate binding site [ion binding]; other site
451516003436	domain II; other site
451516003437	domain III; other site
451516003438	nucleotide binding site [chemical binding]; other site
451516003439	catalytic site [active]
451516003440	domain IV; other site
451516003441	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
451516003442	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
451516003443	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
451516003444	Glucose inhibited division protein A; Region: GIDA; pfam01134
451516003445	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
451516003446	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
451516003447	active site
451516003448	DNA binding site [nucleotide binding]
451516003449	Int/Topo IB signature motif; other site
451516003450	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
451516003451	active site
451516003452	HslU subunit interaction site [polypeptide binding]; other site
451516003453	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
451516003454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516003455	Walker A motif; other site
451516003456	ATP binding site [chemical binding]; other site
451516003457	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
451516003458	Walker B motif; other site
451516003459	arginine finger; other site
451516003460	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
451516003461	transcriptional repressor CodY; Validated; Region: PRK04158
451516003462	CodY GAF-like domain; Region: CodY; pfam06018
451516003463	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
451516003464	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
451516003465	rRNA interaction site [nucleotide binding]; other site
451516003466	S8 interaction site; other site
451516003467	putative laminin-1 binding site; other site
451516003468	elongation factor Ts; Provisional; Region: tsf; PRK09377
451516003469	UBA/TS-N domain; Region: UBA; pfam00627
451516003470	Elongation factor TS; Region: EF_TS; pfam00889
451516003471	Elongation factor TS; Region: EF_TS; pfam00889
451516003472	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
451516003473	putative nucleotide binding site [chemical binding]; other site
451516003474	uridine monophosphate binding site [chemical binding]; other site
451516003475	homohexameric interface [polypeptide binding]; other site
451516003476	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
451516003477	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
451516003478	catalytic residue [active]
451516003479	putative FPP diphosphate  binding site; other site
451516003480	putative FPP binding hydrophobic cleft; other site
451516003481	dimer interface [polypeptide binding]; other site
451516003482	putative IPP diphosphate binding site; other site
451516003483	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
451516003484	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
451516003485	RIP metalloprotease RseP; Region: TIGR00054
451516003486	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
451516003487	active site
451516003488	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
451516003489	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
451516003490	protein binding site [polypeptide binding]; other site
451516003491	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
451516003492	putative substrate binding region [chemical binding]; other site
451516003493	prolyl-tRNA synthetase; Provisional; Region: PRK09194
451516003494	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
451516003495	dimer interface [polypeptide binding]; other site
451516003496	motif 1; other site
451516003497	active site
451516003498	motif 2; other site
451516003499	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
451516003500	putative deacylase active site [active]
451516003501	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
451516003502	active site
451516003503	motif 3; other site
451516003504	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
451516003505	anticodon binding site; other site
451516003506	DNA polymerase III PolC; Validated; Region: polC; PRK00448
451516003507	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
451516003508	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
451516003509	generic binding surface II; other site
451516003510	generic binding surface I; other site
451516003511	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
451516003512	active site
451516003513	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
451516003514	active site
451516003515	catalytic site [active]
451516003516	substrate binding site [chemical binding]; other site
451516003517	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
451516003518	ribosome maturation protein RimP; Reviewed; Region: PRK00092
451516003519	Sm and related proteins; Region: Sm_like; cl00259
451516003520	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
451516003521	putative oligomer interface [polypeptide binding]; other site
451516003522	putative RNA binding site [nucleotide binding]; other site
451516003523	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
451516003524	NusA N-terminal domain; Region: NusA_N; pfam08529
451516003525	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
451516003526	RNA binding site [nucleotide binding]; other site
451516003527	homodimer interface [polypeptide binding]; other site
451516003528	NusA-like KH domain; Region: KH_5; pfam13184
451516003529	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
451516003530	G-X-X-G motif; other site
451516003531	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
451516003532	putative RNA binding cleft [nucleotide binding]; other site
451516003533	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
451516003534	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
451516003535	translation initiation factor IF-2; Region: IF-2; TIGR00487
451516003536	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
451516003537	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
451516003538	G1 box; other site
451516003539	putative GEF interaction site [polypeptide binding]; other site
451516003540	GTP/Mg2+ binding site [chemical binding]; other site
451516003541	Switch I region; other site
451516003542	G2 box; other site
451516003543	G3 box; other site
451516003544	Switch II region; other site
451516003545	G4 box; other site
451516003546	G5 box; other site
451516003547	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
451516003548	Translation-initiation factor 2; Region: IF-2; pfam11987
451516003549	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
451516003550	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
451516003551	tRNA pseudouridine synthase B; Provisional; Region: PRK14123
451516003552	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
451516003553	RNA binding site [nucleotide binding]; other site
451516003554	active site
451516003555	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
451516003556	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
451516003557	active site
451516003558	Riboflavin kinase; Region: Flavokinase; smart00904
451516003559	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
451516003560	16S/18S rRNA binding site [nucleotide binding]; other site
451516003561	S13e-L30e interaction site [polypeptide binding]; other site
451516003562	25S rRNA binding site [nucleotide binding]; other site
451516003563	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
451516003564	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
451516003565	RNase E interface [polypeptide binding]; other site
451516003566	trimer interface [polypeptide binding]; other site
451516003567	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
451516003568	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
451516003569	RNase E interface [polypeptide binding]; other site
451516003570	trimer interface [polypeptide binding]; other site
451516003571	active site
451516003572	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
451516003573	putative nucleic acid binding region [nucleotide binding]; other site
451516003574	G-X-X-G motif; other site
451516003575	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
451516003576	RNA binding site [nucleotide binding]; other site
451516003577	domain interface; other site
451516003578	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
451516003579	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
451516003580	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
451516003581	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
451516003582	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
451516003583	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
451516003584	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
451516003585	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
451516003586	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
451516003587	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
451516003588	DNA-binding site [nucleotide binding]; DNA binding site
451516003589	UTRA domain; Region: UTRA; pfam07702
451516003590	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
451516003591	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
451516003592	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
451516003593	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
451516003594	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
451516003595	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
451516003596	classical (c) SDRs; Region: SDR_c; cd05233
451516003597	NAD(P) binding site [chemical binding]; other site
451516003598	active site
451516003599	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
451516003600	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
451516003601	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
451516003602	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516003603	non-specific DNA binding site [nucleotide binding]; other site
451516003604	salt bridge; other site
451516003605	sequence-specific DNA binding site [nucleotide binding]; other site
451516003606	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
451516003607	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
451516003608	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
451516003609	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
451516003610	putative MPT binding site; other site
451516003611	recombinase A; Provisional; Region: recA; PRK09354
451516003612	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
451516003613	hexamer interface [polypeptide binding]; other site
451516003614	Walker A motif; other site
451516003615	ATP binding site [chemical binding]; other site
451516003616	Walker B motif; other site
451516003617	phosphodiesterase; Provisional; Region: PRK12704
451516003618	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
451516003619	Zn2+ binding site [ion binding]; other site
451516003620	Mg2+ binding site [ion binding]; other site
451516003621	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
451516003622	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
451516003623	putative active site [active]
451516003624	metal binding site [ion binding]; metal-binding site
451516003625	homodimer binding site [polypeptide binding]; other site
451516003626	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
451516003627	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
451516003628	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
451516003629	dimer interface [polypeptide binding]; other site
451516003630	PYR/PP interface [polypeptide binding]; other site
451516003631	TPP binding site [chemical binding]; other site
451516003632	substrate binding site [chemical binding]; other site
451516003633	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
451516003634	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
451516003635	TPP-binding site [chemical binding]; other site
451516003636	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
451516003637	Uncharacterized conserved protein [Function unknown]; Region: COG0011
451516003638	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
451516003639	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
451516003640	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516003641	FeS/SAM binding site; other site
451516003642	TRAM domain; Region: TRAM; pfam01938
451516003643	Predicted membrane protein [Function unknown]; Region: COG4550
451516003644	Predicted membrane protein [Function unknown]; Region: COG4732
451516003645	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
451516003646	MutS domain I; Region: MutS_I; pfam01624
451516003647	MutS domain II; Region: MutS_II; pfam05188
451516003648	MutS domain III; Region: MutS_III; pfam05192
451516003649	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
451516003650	Walker A/P-loop; other site
451516003651	ATP binding site [chemical binding]; other site
451516003652	Q-loop/lid; other site
451516003653	ABC transporter signature motif; other site
451516003654	Walker B; other site
451516003655	D-loop; other site
451516003656	H-loop/switch region; other site
451516003657	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
451516003658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516003659	ATP binding site [chemical binding]; other site
451516003660	Mg2+ binding site [ion binding]; other site
451516003661	G-X-G motif; other site
451516003662	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
451516003663	ATP binding site [chemical binding]; other site
451516003664	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
451516003665	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309
451516003666	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
451516003667	amphipathic channel; other site
451516003668	Asn-Pro-Ala signature motifs; other site
451516003669	glycerol kinase; Provisional; Region: glpK; PRK00047
451516003670	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
451516003671	N- and C-terminal domain interface [polypeptide binding]; other site
451516003672	active site
451516003673	MgATP binding site [chemical binding]; other site
451516003674	catalytic site [active]
451516003675	metal binding site [ion binding]; metal-binding site
451516003676	glycerol binding site [chemical binding]; other site
451516003677	homotetramer interface [polypeptide binding]; other site
451516003678	homodimer interface [polypeptide binding]; other site
451516003679	FBP binding site [chemical binding]; other site
451516003680	protein IIAGlc interface [polypeptide binding]; other site
451516003681	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
451516003682	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
451516003683	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
451516003684	Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209
451516003685	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
451516003686	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
451516003687	bacterial Hfq-like; Region: Hfq; cd01716
451516003688	hexamer interface [polypeptide binding]; other site
451516003689	Sm1 motif; other site
451516003690	RNA binding site [nucleotide binding]; other site
451516003691	Sm2 motif; other site
451516003692	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
451516003693	catalytic residues [active]
451516003694	dimer interface [polypeptide binding]; other site
451516003695	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
451516003696	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
451516003697	HflX GTPase family; Region: HflX; cd01878
451516003698	G1 box; other site
451516003699	GTP/Mg2+ binding site [chemical binding]; other site
451516003700	Switch I region; other site
451516003701	G2 box; other site
451516003702	G3 box; other site
451516003703	Switch II region; other site
451516003704	G4 box; other site
451516003705	G5 box; other site
451516003706	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
451516003707	Aluminium resistance protein; Region: Alum_res; pfam06838
451516003708	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
451516003709	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
451516003710	DNA binding residues [nucleotide binding]
451516003711	putative dimer interface [polypeptide binding]; other site
451516003712	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
451516003713	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
451516003714	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
451516003715	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
451516003716	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
451516003717	Pathogenicity factor; Region: AvrE; pfam11725
451516003718	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
451516003719	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
451516003720	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
451516003721	catalytic residue [active]
451516003722	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
451516003723	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
451516003724	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
451516003725	putative active site [active]
451516003726	catalytic site [active]
451516003727	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
451516003728	putative active site [active]
451516003729	catalytic site [active]
451516003730	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
451516003731	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
451516003732	Walker A/P-loop; other site
451516003733	ATP binding site [chemical binding]; other site
451516003734	Q-loop/lid; other site
451516003735	ABC transporter signature motif; other site
451516003736	Walker B; other site
451516003737	D-loop; other site
451516003738	H-loop/switch region; other site
451516003739	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
451516003740	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
451516003741	Histidine kinase; Region: HisKA_3; pfam07730
451516003742	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
451516003743	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
451516003744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516003745	active site
451516003746	phosphorylation site [posttranslational modification]
451516003747	intermolecular recognition site; other site
451516003748	dimerization interface [polypeptide binding]; other site
451516003749	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
451516003750	DNA binding residues [nucleotide binding]
451516003751	dimerization interface [polypeptide binding]; other site
451516003752	Staphylococcal nuclease homologues; Region: SNc; smart00318
451516003753	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
451516003754	Catalytic site; other site
451516003755	AAA domain; Region: AAA_11; pfam13086
451516003756	aspartate kinase; Reviewed; Region: PRK09034
451516003757	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
451516003758	putative catalytic residues [active]
451516003759	putative nucleotide binding site [chemical binding]; other site
451516003760	putative aspartate binding site [chemical binding]; other site
451516003761	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
451516003762	allosteric regulatory residue; other site
451516003763	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
451516003764	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
451516003765	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
451516003766	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
451516003767	threonine synthase; Reviewed; Region: PRK06721
451516003768	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
451516003769	homodimer interface [polypeptide binding]; other site
451516003770	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516003771	catalytic residue [active]
451516003772	homoserine kinase; Provisional; Region: PRK01212
451516003773	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
451516003774	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
451516003775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516003776	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
451516003777	active site
451516003778	motif I; other site
451516003779	motif II; other site
451516003780	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
451516003781	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
451516003782	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
451516003783	tetramer interface [polypeptide binding]; other site
451516003784	heme binding pocket [chemical binding]; other site
451516003785	NADPH binding site [chemical binding]; other site
451516003786	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
451516003787	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
451516003788	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
451516003789	TPP-binding site [chemical binding]; other site
451516003790	dimer interface [polypeptide binding]; other site
451516003791	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
451516003792	PYR/PP interface [polypeptide binding]; other site
451516003793	dimer interface [polypeptide binding]; other site
451516003794	TPP binding site [chemical binding]; other site
451516003795	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
451516003796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
451516003797	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
451516003798	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
451516003799	Walker A/P-loop; other site
451516003800	ATP binding site [chemical binding]; other site
451516003801	Q-loop/lid; other site
451516003802	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
451516003803	ABC transporter signature motif; other site
451516003804	Walker B; other site
451516003805	D-loop; other site
451516003806	H-loop/switch region; other site
451516003807	aconitate hydratase; Validated; Region: PRK09277
451516003808	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
451516003809	substrate binding site [chemical binding]; other site
451516003810	ligand binding site [chemical binding]; other site
451516003811	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
451516003812	substrate binding site [chemical binding]; other site
451516003813	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
451516003814	active site
451516003815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
451516003816	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
451516003817	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
451516003818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516003819	ATP binding site [chemical binding]; other site
451516003820	Mg2+ binding site [ion binding]; other site
451516003821	G-X-G motif; other site
451516003822	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
451516003823	anchoring element; other site
451516003824	dimer interface [polypeptide binding]; other site
451516003825	ATP binding site [chemical binding]; other site
451516003826	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
451516003827	active site
451516003828	putative metal-binding site [ion binding]; other site
451516003829	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
451516003830	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
451516003831	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
451516003832	CAP-like domain; other site
451516003833	active site
451516003834	primary dimer interface [polypeptide binding]; other site
451516003835	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
451516003836	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
451516003837	amino acid carrier protein; Region: agcS; TIGR00835
451516003838	CAT RNA binding domain; Region: CAT_RBD; smart01061
451516003839	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
451516003840	PRD domain; Region: PRD; pfam00874
451516003841	PRD domain; Region: PRD; pfam00874
451516003842	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
451516003843	Domain of unknown function DUF20; Region: UPF0118; pfam01594
451516003844	Predicted integral membrane protein [Function unknown]; Region: COG0392
451516003845	Uncharacterized conserved protein [Function unknown]; Region: COG2898
451516003846	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
451516003847	methionine sulfoxide reductase A; Provisional; Region: PRK14054
451516003848	Transcriptional regulator [Transcription]; Region: LytR; COG1316
451516003849	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
451516003850	active site 1 [active]
451516003851	dimer interface [polypeptide binding]; other site
451516003852	hexamer interface [polypeptide binding]; other site
451516003853	active site 2 [active]
451516003854	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
451516003855	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
451516003856	active site
451516003857	DNA binding site [nucleotide binding]
451516003858	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
451516003859	prephenate dehydrogenase; Validated; Region: PRK06545
451516003860	prephenate dehydrogenase; Validated; Region: PRK08507
451516003861	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
451516003862	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
451516003863	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
451516003864	putative oligomer interface [polypeptide binding]; other site
451516003865	putative active site [active]
451516003866	metal binding site [ion binding]; metal-binding site
451516003867	anthranilate synthase component I; Provisional; Region: PRK13567
451516003868	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
451516003869	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
451516003870	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
451516003871	Glutamine amidotransferase class-I; Region: GATase; pfam00117
451516003872	glutamine binding [chemical binding]; other site
451516003873	catalytic triad [active]
451516003874	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
451516003875	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
451516003876	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
451516003877	active site
451516003878	ribulose/triose binding site [chemical binding]; other site
451516003879	phosphate binding site [ion binding]; other site
451516003880	substrate (anthranilate) binding pocket [chemical binding]; other site
451516003881	product (indole) binding pocket [chemical binding]; other site
451516003882	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
451516003883	active site
451516003884	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
451516003885	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
451516003886	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516003887	catalytic residue [active]
451516003888	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
451516003889	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
451516003890	substrate binding site [chemical binding]; other site
451516003891	active site
451516003892	catalytic residues [active]
451516003893	heterodimer interface [polypeptide binding]; other site
451516003894	FemAB family; Region: FemAB; pfam02388
451516003895	FlxA-like protein; Region: FlxA; pfam14282
451516003896	FemAB family; Region: FemAB; pfam02388
451516003897	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
451516003898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516003899	active site
451516003900	motif I; other site
451516003901	motif II; other site
451516003902	SWIM zinc finger; Region: SWIM; pfam04434
451516003903	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
451516003904	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516003905	Walker A/P-loop; other site
451516003906	ATP binding site [chemical binding]; other site
451516003907	Q-loop/lid; other site
451516003908	ABC transporter signature motif; other site
451516003909	Walker B; other site
451516003910	D-loop; other site
451516003911	H-loop/switch region; other site
451516003912	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516003913	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
451516003914	Walker A/P-loop; other site
451516003915	ATP binding site [chemical binding]; other site
451516003916	Q-loop/lid; other site
451516003917	ABC transporter signature motif; other site
451516003918	Walker B; other site
451516003919	D-loop; other site
451516003920	H-loop/switch region; other site
451516003921	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
451516003922	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516003923	dimer interface [polypeptide binding]; other site
451516003924	conserved gate region; other site
451516003925	putative PBP binding loops; other site
451516003926	ABC-ATPase subunit interface; other site
451516003927	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
451516003928	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516003929	dimer interface [polypeptide binding]; other site
451516003930	conserved gate region; other site
451516003931	putative PBP binding loops; other site
451516003932	ABC-ATPase subunit interface; other site
451516003933	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
451516003934	oligoendopeptidase F; Region: pepF; TIGR00181
451516003935	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
451516003936	active site
451516003937	Zn binding site [ion binding]; other site
451516003938	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
451516003939	PhoU domain; Region: PhoU; pfam01895
451516003940	PhoU domain; Region: PhoU; pfam01895
451516003941	phosphate transporter ATP-binding protein; Provisional; Region: PRK14238
451516003942	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
451516003943	Walker A/P-loop; other site
451516003944	ATP binding site [chemical binding]; other site
451516003945	Q-loop/lid; other site
451516003946	ABC transporter signature motif; other site
451516003947	Walker B; other site
451516003948	D-loop; other site
451516003949	H-loop/switch region; other site
451516003950	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
451516003951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516003952	dimer interface [polypeptide binding]; other site
451516003953	conserved gate region; other site
451516003954	putative PBP binding loops; other site
451516003955	ABC-ATPase subunit interface; other site
451516003956	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
451516003957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516003958	dimer interface [polypeptide binding]; other site
451516003959	conserved gate region; other site
451516003960	ABC-ATPase subunit interface; other site
451516003961	phosphate binding protein; Region: ptsS_2; TIGR02136
451516003962	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
451516003963	S1 domain; Region: S1_2; pfam13509
451516003964	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
451516003965	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
451516003966	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
451516003967	ABC transporter; Region: ABC_tran_2; pfam12848
451516003968	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
451516003969	aspartate kinase; Reviewed; Region: PRK06635
451516003970	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
451516003971	putative nucleotide binding site [chemical binding]; other site
451516003972	putative catalytic residues [active]
451516003973	putative Mg ion binding site [ion binding]; other site
451516003974	putative aspartate binding site [chemical binding]; other site
451516003975	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
451516003976	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
451516003977	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
451516003978	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
451516003979	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
451516003980	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
451516003981	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
451516003982	dimer interface [polypeptide binding]; other site
451516003983	active site
451516003984	catalytic residue [active]
451516003985	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
451516003986	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
451516003987	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
451516003988	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
451516003989	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
451516003990	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
451516003991	active site
451516003992	trimer interface [polypeptide binding]; other site
451516003993	substrate binding site [chemical binding]; other site
451516003994	CoA binding site [chemical binding]; other site
451516003995	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
451516003996	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
451516003997	metal binding site [ion binding]; metal-binding site
451516003998	dimer interface [polypeptide binding]; other site
451516003999	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
451516004000	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
451516004001	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
451516004002	catalytic residue [active]
451516004003	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
451516004004	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
451516004005	active site
451516004006	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
451516004007	substrate binding site [chemical binding]; other site
451516004008	catalytic residues [active]
451516004009	dimer interface [polypeptide binding]; other site
451516004010	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
451516004011	DNA-binding site [nucleotide binding]; DNA binding site
451516004012	RNA-binding motif; other site
451516004013	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
451516004014	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
451516004015	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
451516004016	Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114
451516004017	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
451516004018	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
451516004019	metal ion-dependent adhesion site (MIDAS); other site
451516004020	MoxR-like ATPases [General function prediction only]; Region: COG0714
451516004021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516004022	Walker A motif; other site
451516004023	ATP binding site [chemical binding]; other site
451516004024	Walker B motif; other site
451516004025	arginine finger; other site
451516004026	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
451516004027	active site
451516004028	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
451516004029	active site
451516004030	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
451516004031	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
451516004032	E3 interaction surface; other site
451516004033	lipoyl attachment site [posttranslational modification]; other site
451516004034	e3 binding domain; Region: E3_binding; pfam02817
451516004035	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
451516004036	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
451516004037	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
451516004038	TPP-binding site [chemical binding]; other site
451516004039	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
451516004040	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
451516004041	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
451516004042	HAMP domain; Region: HAMP; pfam00672
451516004043	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
451516004044	dimer interface [polypeptide binding]; other site
451516004045	phosphorylation site [posttranslational modification]
451516004046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516004047	ATP binding site [chemical binding]; other site
451516004048	Mg2+ binding site [ion binding]; other site
451516004049	G-X-G motif; other site
451516004050	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
451516004051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516004052	active site
451516004053	phosphorylation site [posttranslational modification]
451516004054	intermolecular recognition site; other site
451516004055	dimerization interface [polypeptide binding]; other site
451516004056	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
451516004057	DNA binding site [nucleotide binding]
451516004058	Transposase IS200 like; Region: Y1_Tnp; pfam01797
451516004059	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
451516004060	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
451516004061	active site
451516004062	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
451516004063	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
451516004064	active site
451516004065	homodimer interface [polypeptide binding]; other site
451516004066	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516004067	Coenzyme A binding pocket [chemical binding]; other site
451516004068	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
451516004069	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
451516004070	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
451516004071	protein binding site [polypeptide binding]; other site
451516004072	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
451516004073	Catalytic dyad [active]
451516004074	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
451516004075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479
451516004076	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
451516004077	HPr interaction site; other site
451516004078	glycerol kinase (GK) interaction site [polypeptide binding]; other site
451516004079	active site
451516004080	phosphorylation site [posttranslational modification]
451516004081	methionine sulfoxide reductase B; Provisional; Region: PRK00222
451516004082	SelR domain; Region: SelR; pfam01641
451516004083	methionine sulfoxide reductase A; Provisional; Region: PRK13014
451516004084	EDD domain protein, DegV family; Region: DegV; TIGR00762
451516004085	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
451516004086	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
451516004087	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
451516004088	folate binding site [chemical binding]; other site
451516004089	NADP+ binding site [chemical binding]; other site
451516004090	thymidylate synthase; Region: thym_sym; TIGR03284
451516004091	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
451516004092	dimerization interface [polypeptide binding]; other site
451516004093	active site
451516004094	Disulphide isomerase; Region: Disulph_isomer; pfam06491
451516004095	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
451516004096	Virulence factor; Region: Virulence_fact; pfam13769
451516004097	HEAT repeats; Region: HEAT_2; pfam13646
451516004098	HEAT repeat; Region: HEAT; pfam02985
451516004099	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
451516004100	Protein of unknown function (DUF2602); Region: DUF2602; pfam10782
451516004101	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
451516004102	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
451516004103	RNA/DNA hybrid binding site [nucleotide binding]; other site
451516004104	active site
451516004105	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516004106	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
451516004107	GA module; Region: GA; smart00844
451516004108	GA module; Region: GA; smart00844
451516004109	GA module; Region: GA; smart00844
451516004110	GA module; Region: GA; smart00844
451516004111	GA module; Region: GA; smart00844
451516004112	GA module; Region: GA; smart00844
451516004113	GA module; Region: GA; smart00844
451516004114	GA module; Region: GA; smart00844
451516004115	GA module; Region: GA; smart00844
451516004116	GA module; Region: GA; smart00844
451516004117	GA module; Region: GA; smart00844
451516004118	GA module; Region: GA; smart00844
451516004119	GA module; Region: GA; smart00844
451516004120	GA module; Region: GA; smart00844
451516004121	GA module; Region: GA; smart00844
451516004122	GA module; Region: GA; smart00844
451516004123	GA module; Region: GA; smart00844
451516004124	GA module; Region: GA; smart00844
451516004125	GA module; Region: GA; smart00844
451516004126	GA module; Region: GA; pfam01468
451516004127	GA module; Region: GA; smart00844
451516004128	GA module; Region: GA; smart00844
451516004129	GA module; Region: GA; smart00844
451516004130	GA module; Region: GA; smart00844
451516004131	Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554
451516004132	GA module; Region: GA; smart00844
451516004133	GA module; Region: GA; smart00844
451516004134	GA module; Region: GA; smart00844
451516004135	GA module; Region: GA; smart00844
451516004136	GA module; Region: GA; smart00844
451516004137	GA module; Region: GA; smart00844
451516004138	GA module; Region: GA; smart00844
451516004139	GA module; Region: GA; pfam01468
451516004140	GA module; Region: GA; smart00844
451516004141	GA module; Region: GA; smart00844
451516004142	GA module; Region: GA; smart00844
451516004143	GA module; Region: GA; smart00844
451516004144	GA module; Region: GA; smart00844
451516004145	GA module; Region: GA; smart00844
451516004146	GA module; Region: GA; smart00844
451516004147	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
451516004148	GA module; Region: GA; smart00844
451516004149	GA module; Region: GA; smart00844
451516004150	GA module; Region: GA; smart00844
451516004151	GA module; Region: GA; smart00844
451516004152	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516004153	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516004154	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
451516004155	Amino acid permease; Region: AA_permease_2; pfam13520
451516004156	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
451516004157	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
451516004158	tetramer interface [polypeptide binding]; other site
451516004159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516004160	catalytic residue [active]
451516004161	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
451516004162	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
451516004163	hexamer interface [polypeptide binding]; other site
451516004164	ligand binding site [chemical binding]; other site
451516004165	putative active site [active]
451516004166	NAD(P) binding site [chemical binding]; other site
451516004167	5'-3' exonuclease; Region: 53EXOc; smart00475
451516004168	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
451516004169	active site
451516004170	metal binding site 1 [ion binding]; metal-binding site
451516004171	putative 5' ssDNA interaction site; other site
451516004172	metal binding site 3; metal-binding site
451516004173	metal binding site 2 [ion binding]; metal-binding site
451516004174	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
451516004175	putative DNA binding site [nucleotide binding]; other site
451516004176	putative metal binding site [ion binding]; other site
451516004177	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
451516004178	Dynamin family; Region: Dynamin_N; pfam00350
451516004179	G1 box; other site
451516004180	GTP/Mg2+ binding site [chemical binding]; other site
451516004181	G2 box; other site
451516004182	Switch I region; other site
451516004183	G3 box; other site
451516004184	Switch II region; other site
451516004185	G4 box; other site
451516004186	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
451516004187	Dynamin family; Region: Dynamin_N; pfam00350
451516004188	G1 box; other site
451516004189	GTP/Mg2+ binding site [chemical binding]; other site
451516004190	G2 box; other site
451516004191	Switch I region; other site
451516004192	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
451516004193	G3 box; other site
451516004194	Switch II region; other site
451516004195	GTP/Mg2+ binding site [chemical binding]; other site
451516004196	G4 box; other site
451516004197	G5 box; other site
451516004198	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
451516004199	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
451516004200	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
451516004201	Cobalt transport protein component CbiN; Region: CbiN; cl00842
451516004202	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
451516004203	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
451516004204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
451516004205	cell division protein GpsB; Provisional; Region: PRK14127
451516004206	DivIVA domain; Region: DivI1A_domain; TIGR03544
451516004207	hypothetical protein; Provisional; Region: PRK13660
451516004208	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
451516004209	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
451516004210	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
451516004211	Transglycosylase; Region: Transgly; pfam00912
451516004212	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
451516004213	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
451516004214	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
451516004215	minor groove reading motif; other site
451516004216	helix-hairpin-helix signature motif; other site
451516004217	substrate binding pocket [chemical binding]; other site
451516004218	active site
451516004219	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
451516004220	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
451516004221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
451516004222	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
451516004223	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
451516004224	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
451516004225	putative dimer interface [polypeptide binding]; other site
451516004226	putative anticodon binding site; other site
451516004227	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
451516004228	homodimer interface [polypeptide binding]; other site
451516004229	motif 1; other site
451516004230	motif 2; other site
451516004231	active site
451516004232	motif 3; other site
451516004233	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
451516004234	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
451516004235	active site
451516004236	catalytic site [active]
451516004237	substrate binding site [chemical binding]; other site
451516004238	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
451516004239	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
451516004240	Biotin operon repressor [Transcription]; Region: BirA; COG1654
451516004241	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
451516004242	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
451516004243	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
451516004244	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
451516004245	active site
451516004246	NTP binding site [chemical binding]; other site
451516004247	metal binding triad [ion binding]; metal-binding site
451516004248	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
451516004249	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
451516004250	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
451516004251	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
451516004252	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
451516004253	homodimer interface [polypeptide binding]; other site
451516004254	metal binding site [ion binding]; metal-binding site
451516004255	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
451516004256	Predicted membrane protein [Function unknown]; Region: COG4347
451516004257	Uncharacterized conserved protein [Function unknown]; Region: COG5582
451516004258	UPF0302 domain; Region: UPF0302; pfam08864
451516004259	A short protein domain of unknown function; Region: IDEAL; smart00914
451516004260	TPR repeat; Region: TPR_11; pfam13414
451516004261	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
451516004262	binding surface
451516004263	TPR motif; other site
451516004264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
451516004265	TPR motif; other site
451516004266	binding surface
451516004267	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
451516004268	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
451516004269	hinge; other site
451516004270	active site
451516004271	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
451516004272	active site
451516004273	NAD binding site [chemical binding]; other site
451516004274	metal binding site [ion binding]; metal-binding site
451516004275	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
451516004276	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
451516004277	Tetramer interface [polypeptide binding]; other site
451516004278	active site
451516004279	FMN-binding site [chemical binding]; other site
451516004280	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
451516004281	active site
451516004282	multimer interface [polypeptide binding]; other site
451516004283	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
451516004284	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
451516004285	substrate binding pocket [chemical binding]; other site
451516004286	chain length determination region; other site
451516004287	substrate-Mg2+ binding site; other site
451516004288	catalytic residues [active]
451516004289	aspartate-rich region 1; other site
451516004290	active site lid residues [active]
451516004291	aspartate-rich region 2; other site
451516004292	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
451516004293	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516004294	S-adenosylmethionine binding site [chemical binding]; other site
451516004295	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
451516004296	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
451516004297	IHF dimer interface [polypeptide binding]; other site
451516004298	IHF - DNA interface [nucleotide binding]; other site
451516004299	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
451516004300	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
451516004301	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
451516004302	GTP-binding protein Der; Reviewed; Region: PRK00093
451516004303	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
451516004304	G1 box; other site
451516004305	GTP/Mg2+ binding site [chemical binding]; other site
451516004306	Switch I region; other site
451516004307	G2 box; other site
451516004308	Switch II region; other site
451516004309	G3 box; other site
451516004310	G4 box; other site
451516004311	G5 box; other site
451516004312	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
451516004313	G1 box; other site
451516004314	GTP/Mg2+ binding site [chemical binding]; other site
451516004315	Switch I region; other site
451516004316	G2 box; other site
451516004317	G3 box; other site
451516004318	Switch II region; other site
451516004319	G4 box; other site
451516004320	G5 box; other site
451516004321	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
451516004322	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
451516004323	RNA binding site [nucleotide binding]; other site
451516004324	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
451516004325	RNA binding site [nucleotide binding]; other site
451516004326	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
451516004327	RNA binding site [nucleotide binding]; other site
451516004328	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
451516004329	RNA binding site [nucleotide binding]; other site
451516004330	cytidylate kinase; Provisional; Region: cmk; PRK00023
451516004331	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
451516004332	CMP-binding site; other site
451516004333	The sites determining sugar specificity; other site
451516004334	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
451516004335	active site
451516004336	homotetramer interface [polypeptide binding]; other site
451516004337	homodimer interface [polypeptide binding]; other site
451516004338	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
451516004339	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
451516004340	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516004341	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
451516004342	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
451516004343	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516004344	ATP binding site [chemical binding]; other site
451516004345	putative Mg++ binding site [ion binding]; other site
451516004346	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
451516004347	nucleotide binding region [chemical binding]; other site
451516004348	ATP-binding site [chemical binding]; other site
451516004349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
451516004350	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
451516004351	Predicted membrane protein [Function unknown]; Region: COG3601
451516004352	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
451516004353	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
451516004354	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
451516004355	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
451516004356	beta-channel forming cytolysin; Region: hlyII; TIGR01002
451516004357	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
451516004358	CHAP domain; Region: CHAP; pfam05257
451516004359	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
451516004360	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
451516004361	active site
451516004362	metal binding site [ion binding]; metal-binding site
451516004363	Bacterial SH3 domain; Region: SH3_5; pfam08460
451516004364	holin, SPP1 family; Region: holin_SPP1; TIGR01592
451516004365	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
451516004366	Protein of unknown function (DUF2977); Region: DUF2977; pfam11192
451516004367	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
451516004368	hypothetical protein; Provisional; Region: PRK05926
451516004369	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
451516004370	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
451516004371	Phage tail protein; Region: Sipho_tail; pfam05709
451516004372	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
451516004373	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
451516004374	linker region; other site
451516004375	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
451516004376	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
451516004377	dimer interface [polypeptide binding]; other site
451516004378	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
451516004379	Peptidase family M23; Region: Peptidase_M23; pfam01551
451516004380	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
451516004381	N-acetyl-D-glucosamine binding site [chemical binding]; other site
451516004382	catalytic residue [active]
451516004383	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
451516004384	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
451516004385	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
451516004386	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
451516004387	oligomerization interface [polypeptide binding]; other site
451516004388	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
451516004389	Phage capsid family; Region: Phage_capsid; pfam05065
451516004390	Clp protease; Region: CLP_protease; pfam00574
451516004391	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
451516004392	oligomer interface [polypeptide binding]; other site
451516004393	active site residues [active]
451516004394	Phage-related protein [Function unknown]; Region: COG4695; cl01923
451516004395	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
451516004396	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
451516004397	Phage terminase, small subunit; Region: Terminase_4; pfam05119
451516004398	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
451516004399	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
451516004400	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516004401	ATP binding site [chemical binding]; other site
451516004402	putative Mg++ binding site [ion binding]; other site
451516004403	helicase superfamily c-terminal domain; Region: HELICc; smart00490
451516004404	VRR-NUC domain; Region: VRR_NUC; pfam08774
451516004405	Virulence-associated protein E; Region: VirE; pfam05272
451516004406	Protein of unknown function (DUF1514); Region: DUF1514; pfam07438
451516004407	Transcriptional activator RinB; Region: RinB; pfam06116
451516004408	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
451516004409	Protein of unknown function (DUF1381); Region: DUF1381; pfam07129
451516004410	dUTPase; Region: dUTPase_2; pfam08761
451516004411	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
451516004412	active site
451516004413	homodimer interface [polypeptide binding]; other site
451516004414	metal binding site [ion binding]; metal-binding site
451516004415	Protein of unknown function (DUF1024); Region: DUF1024; pfam06260
451516004416	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
451516004417	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
451516004418	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
451516004419	Protein of unknown function (DUF3113); Region: DUF3113; pfam11310
451516004420	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
451516004421	active site
451516004422	DNA binding site [nucleotide binding]
451516004423	catalytic site [active]
451516004424	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
451516004425	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
451516004426	Protein of unknown function (DUF1108); Region: DUF1108; pfam06531
451516004427	Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655
451516004428	Homeodomain-like domain; Region: HTH_23; pfam13384
451516004429	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516004430	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
451516004431	non-specific DNA binding site [nucleotide binding]; other site
451516004432	salt bridge; other site
451516004433	sequence-specific DNA binding site [nucleotide binding]; other site
451516004434	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
451516004435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516004436	non-specific DNA binding site [nucleotide binding]; other site
451516004437	salt bridge; other site
451516004438	sequence-specific DNA binding site [nucleotide binding]; other site
451516004439	Domain of unknown function (DUF955); Region: DUF955; cl01076
451516004440	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
451516004441	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
451516004442	Int/Topo IB signature motif; other site
451516004443	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
451516004444	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
451516004445	dimerization interface [polypeptide binding]; other site
451516004446	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
451516004447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
451516004448	dimer interface [polypeptide binding]; other site
451516004449	phosphorylation site [posttranslational modification]
451516004450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516004451	ATP binding site [chemical binding]; other site
451516004452	Mg2+ binding site [ion binding]; other site
451516004453	G-X-G motif; other site
451516004454	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
451516004455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516004456	active site
451516004457	phosphorylation site [posttranslational modification]
451516004458	intermolecular recognition site; other site
451516004459	dimerization interface [polypeptide binding]; other site
451516004460	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
451516004461	DNA binding site [nucleotide binding]
451516004462	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
451516004463	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
451516004464	RNA binding surface [nucleotide binding]; other site
451516004465	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
451516004466	active site
451516004467	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
451516004468	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
451516004469	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
451516004470	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
451516004471	active site
451516004472	Int/Topo IB signature motif; other site
451516004473	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
451516004474	metal binding site 2 [ion binding]; metal-binding site
451516004475	putative DNA binding helix; other site
451516004476	metal binding site 1 [ion binding]; metal-binding site
451516004477	dimer interface [polypeptide binding]; other site
451516004478	structural Zn2+ binding site [ion binding]; other site
451516004479	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
451516004480	dimer interface [polypeptide binding]; other site
451516004481	ADP-ribose binding site [chemical binding]; other site
451516004482	active site
451516004483	nudix motif; other site
451516004484	metal binding site [ion binding]; metal-binding site
451516004485	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
451516004486	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
451516004487	active site
451516004488	catalytic tetrad [active]
451516004489	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
451516004490	classical (c) SDRs; Region: SDR_c; cd05233
451516004491	NAD(P) binding site [chemical binding]; other site
451516004492	active site
451516004493	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
451516004494	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
451516004495	ribonuclease Z; Region: RNase_Z; TIGR02651
451516004496	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
451516004497	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
451516004498	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
451516004499	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
451516004500	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
451516004501	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
451516004502	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
451516004503	Ca binding site [ion binding]; other site
451516004504	active site
451516004505	catalytic site [active]
451516004506	Transcriptional regulators [Transcription]; Region: PurR; COG1609
451516004507	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
451516004508	DNA binding site [nucleotide binding]
451516004509	domain linker motif; other site
451516004510	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
451516004511	putative ligand binding site [chemical binding]; other site
451516004512	putative dimerization interface [polypeptide binding]; other site
451516004513	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
451516004514	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
451516004515	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
451516004516	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
451516004517	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
451516004518	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
451516004519	peptidase T-like protein; Region: PepT-like; TIGR01883
451516004520	metal binding site [ion binding]; metal-binding site
451516004521	putative dimer interface [polypeptide binding]; other site
451516004522	Predicted membrane protein [Function unknown]; Region: COG4129
451516004523	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
451516004524	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
451516004525	Disulphide isomerase; Region: Disulph_isomer; pfam06491
451516004526	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
451516004527	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
451516004528	E3 interaction surface; other site
451516004529	lipoyl attachment site [posttranslational modification]; other site
451516004530	e3 binding domain; Region: E3_binding; pfam02817
451516004531	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
451516004532	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
451516004533	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
451516004534	alpha subunit interface [polypeptide binding]; other site
451516004535	TPP binding site [chemical binding]; other site
451516004536	heterodimer interface [polypeptide binding]; other site
451516004537	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
451516004538	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
451516004539	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
451516004540	tetramer interface [polypeptide binding]; other site
451516004541	TPP-binding site [chemical binding]; other site
451516004542	heterodimer interface [polypeptide binding]; other site
451516004543	phosphorylation loop region [posttranslational modification]
451516004544	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
451516004545	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
451516004546	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516004547	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
451516004548	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
451516004549	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
451516004550	Walker A/P-loop; other site
451516004551	ATP binding site [chemical binding]; other site
451516004552	Q-loop/lid; other site
451516004553	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
451516004554	ABC transporter signature motif; other site
451516004555	Walker B; other site
451516004556	D-loop; other site
451516004557	H-loop/switch region; other site
451516004558	arginine repressor; Provisional; Region: PRK04280
451516004559	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
451516004560	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
451516004561	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
451516004562	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
451516004563	substrate binding pocket [chemical binding]; other site
451516004564	chain length determination region; other site
451516004565	substrate-Mg2+ binding site; other site
451516004566	catalytic residues [active]
451516004567	aspartate-rich region 1; other site
451516004568	active site lid residues [active]
451516004569	aspartate-rich region 2; other site
451516004570	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068
451516004571	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
451516004572	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
451516004573	generic binding surface II; other site
451516004574	generic binding surface I; other site
451516004575	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
451516004576	putative RNA binding site [nucleotide binding]; other site
451516004577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
451516004578	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
451516004579	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
451516004580	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
451516004581	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
451516004582	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
451516004583	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
451516004584	carboxyltransferase (CT) interaction site; other site
451516004585	biotinylation site [posttranslational modification]; other site
451516004586	elongation factor P; Validated; Region: PRK00529
451516004587	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
451516004588	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
451516004589	RNA binding site [nucleotide binding]; other site
451516004590	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
451516004591	RNA binding site [nucleotide binding]; other site
451516004592	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
451516004593	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
451516004594	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
451516004595	active site
451516004596	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
451516004597	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
451516004598	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
451516004599	active site residue [active]
451516004600	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
451516004601	tetramer interface [polypeptide binding]; other site
451516004602	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516004603	catalytic residue [active]
451516004604	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
451516004605	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
451516004606	tetramer interface [polypeptide binding]; other site
451516004607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516004608	catalytic residue [active]
451516004609	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
451516004610	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
451516004611	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
451516004612	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
451516004613	ADP binding site [chemical binding]; other site
451516004614	magnesium binding site [ion binding]; other site
451516004615	putative shikimate binding site; other site
451516004616	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
451516004617	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
451516004618	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
451516004619	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
451516004620	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
451516004621	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
451516004622	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
451516004623	Type II/IV secretion system protein; Region: T2SE; pfam00437
451516004624	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
451516004625	Walker A motif; other site
451516004626	ATP binding site [chemical binding]; other site
451516004627	Walker B motif; other site
451516004628	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
451516004629	Uncharacterized conserved protein [Function unknown]; Region: COG0011
451516004630	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
451516004631	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
451516004632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
451516004633	Rhomboid family; Region: Rhomboid; pfam01694
451516004634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
451516004635	binding surface
451516004636	TPR motif; other site
451516004637	Tetratricopeptide repeat; Region: TPR_16; pfam13432
451516004638	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
451516004639	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
451516004640	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
451516004641	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
451516004642	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
451516004643	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
451516004644	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
451516004645	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
451516004646	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
451516004647	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
451516004648	metal binding site 2 [ion binding]; metal-binding site
451516004649	putative DNA binding helix; other site
451516004650	metal binding site 1 [ion binding]; metal-binding site
451516004651	dimer interface [polypeptide binding]; other site
451516004652	structural Zn2+ binding site [ion binding]; other site
451516004653	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
451516004654	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516004655	ABC-ATPase subunit  interface; other site
451516004656	dimer interface [polypeptide binding]; other site
451516004657	putative PBP binding regions; other site
451516004658	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
451516004659	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
451516004660	endonuclease IV; Provisional; Region: PRK01060
451516004661	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
451516004662	AP (apurinic/apyrimidinic) site pocket; other site
451516004663	DNA interaction; other site
451516004664	Metal-binding active site; metal-binding site
451516004665	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
451516004666	DEAD-like helicases superfamily; Region: DEXDc; smart00487
451516004667	ATP binding site [chemical binding]; other site
451516004668	Mg++ binding site [ion binding]; other site
451516004669	motif III; other site
451516004670	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
451516004671	nucleotide binding region [chemical binding]; other site
451516004672	ATP-binding site [chemical binding]; other site
451516004673	Uncharacterized conserved protein [Function unknown]; Region: COG0327
451516004674	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
451516004675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
451516004676	Uncharacterized conserved protein [Function unknown]; Region: COG0327
451516004677	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
451516004678	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
451516004679	Family of unknown function (DUF633); Region: DUF633; pfam04816
451516004680	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
451516004681	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
451516004682	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
451516004683	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
451516004684	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
451516004685	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
451516004686	DNA binding residues [nucleotide binding]
451516004687	DNA primase, catalytic core; Region: dnaG; TIGR01391
451516004688	CHC2 zinc finger; Region: zf-CHC2; pfam01807
451516004689	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
451516004690	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
451516004691	active site
451516004692	metal binding site [ion binding]; metal-binding site
451516004693	interdomain interaction site; other site
451516004694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
451516004695	glycyl-tRNA synthetase; Provisional; Region: PRK04173
451516004696	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
451516004697	motif 1; other site
451516004698	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
451516004699	active site
451516004700	motif 2; other site
451516004701	motif 3; other site
451516004702	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
451516004703	anticodon binding site; other site
451516004704	DNA repair protein RecO; Region: reco; TIGR00613
451516004705	Recombination protein O N terminal; Region: RecO_N; pfam11967
451516004706	Recombination protein O C terminal; Region: RecO_C; pfam02565
451516004707	GTPase Era; Reviewed; Region: era; PRK00089
451516004708	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
451516004709	G1 box; other site
451516004710	GTP/Mg2+ binding site [chemical binding]; other site
451516004711	Switch I region; other site
451516004712	G2 box; other site
451516004713	Switch II region; other site
451516004714	G3 box; other site
451516004715	G4 box; other site
451516004716	G5 box; other site
451516004717	KH domain; Region: KH_2; pfam07650
451516004718	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
451516004719	active site
451516004720	catalytic motif [active]
451516004721	Zn binding site [ion binding]; other site
451516004722	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
451516004723	metal-binding heat shock protein; Provisional; Region: PRK00016
451516004724	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
451516004725	PhoH-like protein; Region: PhoH; pfam02562
451516004726	hypothetical protein; Provisional; Region: PRK13665
451516004727	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
451516004728	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
451516004729	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
451516004730	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
451516004731	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516004732	FeS/SAM binding site; other site
451516004733	TRAM domain; Region: TRAM; cl01282
451516004734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
451516004735	RNA methyltransferase, RsmE family; Region: TIGR00046
451516004736	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
451516004737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516004738	S-adenosylmethionine binding site [chemical binding]; other site
451516004739	chaperone protein DnaJ; Provisional; Region: PRK14280
451516004740	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
451516004741	HSP70 interaction site [polypeptide binding]; other site
451516004742	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
451516004743	substrate binding site [polypeptide binding]; other site
451516004744	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
451516004745	Zn binding sites [ion binding]; other site
451516004746	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
451516004747	dimer interface [polypeptide binding]; other site
451516004748	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
451516004749	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
451516004750	nucleotide binding site [chemical binding]; other site
451516004751	NEF interaction site [polypeptide binding]; other site
451516004752	SBD interface [polypeptide binding]; other site
451516004753	heat shock protein GrpE; Provisional; Region: PRK14140
451516004754	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
451516004755	dimer interface [polypeptide binding]; other site
451516004756	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
451516004757	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
451516004758	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
451516004759	Tubulin C-terminal domain; Region: Tubulin_C; cl10021
451516004760	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
451516004761	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516004762	FeS/SAM binding site; other site
451516004763	HemN C-terminal domain; Region: HemN_C; pfam06969
451516004764	GTP-binding protein LepA; Provisional; Region: PRK05433
451516004765	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
451516004766	G1 box; other site
451516004767	putative GEF interaction site [polypeptide binding]; other site
451516004768	GTP/Mg2+ binding site [chemical binding]; other site
451516004769	Switch I region; other site
451516004770	G2 box; other site
451516004771	G3 box; other site
451516004772	Switch II region; other site
451516004773	G4 box; other site
451516004774	G5 box; other site
451516004775	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
451516004776	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
451516004777	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
451516004778	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
451516004779	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
451516004780	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
451516004781	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
451516004782	Competence protein; Region: Competence; pfam03772
451516004783	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
451516004784	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
451516004785	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
451516004786	catalytic motif [active]
451516004787	Zn binding site [ion binding]; other site
451516004788	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
451516004789	SLBB domain; Region: SLBB; pfam10531
451516004790	Helix-hairpin-helix motif; Region: HHH; pfam00633
451516004791	Methyltransferase domain; Region: Methyltransf_31; pfam13847
451516004792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516004793	S-adenosylmethionine binding site [chemical binding]; other site
451516004794	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
451516004795	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
451516004796	Zn2+ binding site [ion binding]; other site
451516004797	Mg2+ binding site [ion binding]; other site
451516004798	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
451516004799	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
451516004800	active site
451516004801	(T/H)XGH motif; other site
451516004802	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
451516004803	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
451516004804	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
451516004805	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
451516004806	shikimate binding site; other site
451516004807	NAD(P) binding site [chemical binding]; other site
451516004808	GTPase YqeH; Provisional; Region: PRK13796
451516004809	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
451516004810	GTP/Mg2+ binding site [chemical binding]; other site
451516004811	G4 box; other site
451516004812	G5 box; other site
451516004813	G1 box; other site
451516004814	Switch I region; other site
451516004815	G2 box; other site
451516004816	G3 box; other site
451516004817	Switch II region; other site
451516004818	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
451516004819	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516004820	active site
451516004821	motif I; other site
451516004822	motif II; other site
451516004823	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
451516004824	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
451516004825	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
451516004826	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
451516004827	Fic family protein [Function unknown]; Region: COG3177
451516004828	Fic/DOC family; Region: Fic; pfam02661
451516004829	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
451516004830	putative active site [active]
451516004831	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
451516004832	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
451516004833	ATP-grasp domain; Region: ATP-grasp_4; cl17255
451516004834	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
451516004835	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
451516004836	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
451516004837	carboxyltransferase (CT) interaction site; other site
451516004838	biotinylation site [posttranslational modification]; other site
451516004839	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
451516004840	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
451516004841	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
451516004842	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
451516004843	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
451516004844	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
451516004845	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
451516004846	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
451516004847	Sugar specificity; other site
451516004848	Pyrimidine base specificity; other site
451516004849	ATP-binding site [chemical binding]; other site
451516004850	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
451516004851	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
451516004852	Peptidase family U32; Region: Peptidase_U32; pfam01136
451516004853	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
451516004854	Peptidase family U32; Region: Peptidase_U32; pfam01136
451516004855	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
451516004856	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516004857	S-adenosylmethionine binding site [chemical binding]; other site
451516004858	hypothetical protein; Provisional; Region: PRK13678
451516004859	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
451516004860	hypothetical protein; Provisional; Region: PRK05473
451516004861	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
451516004862	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
451516004863	motif 1; other site
451516004864	active site
451516004865	motif 2; other site
451516004866	motif 3; other site
451516004867	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
451516004868	DHHA1 domain; Region: DHHA1; pfam02272
451516004869	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
451516004870	AAA domain; Region: AAA_30; pfam13604
451516004871	Family description; Region: UvrD_C_2; pfam13538
451516004872	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
451516004873	binding surface
451516004874	TPR motif; other site
451516004875	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
451516004876	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
451516004877	binding surface
451516004878	TPR motif; other site
451516004879	TPR repeat; Region: TPR_11; pfam13414
451516004880	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
451516004881	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
451516004882	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
451516004883	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
451516004884	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
451516004885	catalytic residue [active]
451516004886	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
451516004887	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
451516004888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
451516004889	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
451516004890	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
451516004891	putative ATP binding site [chemical binding]; other site
451516004892	putative substrate interface [chemical binding]; other site
451516004893	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
451516004894	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
451516004895	dimer interface [polypeptide binding]; other site
451516004896	anticodon binding site; other site
451516004897	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
451516004898	homodimer interface [polypeptide binding]; other site
451516004899	motif 1; other site
451516004900	active site
451516004901	motif 2; other site
451516004902	GAD domain; Region: GAD; pfam02938
451516004903	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
451516004904	motif 3; other site
451516004905	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
451516004906	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
451516004907	dimer interface [polypeptide binding]; other site
451516004908	motif 1; other site
451516004909	active site
451516004910	motif 2; other site
451516004911	motif 3; other site
451516004912	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
451516004913	anticodon binding site; other site
451516004914	Bacterial SH3 domain homologues; Region: SH3b; smart00287
451516004915	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
451516004916	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
451516004917	active site
451516004918	metal binding site [ion binding]; metal-binding site
451516004919	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
451516004920	putative active site [active]
451516004921	dimerization interface [polypeptide binding]; other site
451516004922	putative tRNAtyr binding site [nucleotide binding]; other site
451516004923	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
451516004924	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
451516004925	Zn2+ binding site [ion binding]; other site
451516004926	Mg2+ binding site [ion binding]; other site
451516004927	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
451516004928	synthetase active site [active]
451516004929	NTP binding site [chemical binding]; other site
451516004930	metal binding site [ion binding]; metal-binding site
451516004931	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
451516004932	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
451516004933	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
451516004934	active site
451516004935	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
451516004936	DHH family; Region: DHH; pfam01368
451516004937	DHHA1 domain; Region: DHHA1; pfam02272
451516004938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
451516004939	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
451516004940	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
451516004941	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
451516004942	Protein export membrane protein; Region: SecD_SecF; pfam02355
451516004943	Preprotein translocase subunit; Region: YajC; pfam02699
451516004944	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
451516004945	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
451516004946	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
451516004947	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
451516004948	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
451516004949	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516004950	Walker A motif; other site
451516004951	ATP binding site [chemical binding]; other site
451516004952	Walker B motif; other site
451516004953	arginine finger; other site
451516004954	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
451516004955	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
451516004956	RuvA N terminal domain; Region: RuvA_N; pfam01330
451516004957	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
451516004958	ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492
451516004959	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
451516004960	GTPase CgtA; Reviewed; Region: obgE; PRK12297
451516004961	GTP1/OBG; Region: GTP1_OBG; pfam01018
451516004962	Obg GTPase; Region: Obg; cd01898
451516004963	G1 box; other site
451516004964	GTP/Mg2+ binding site [chemical binding]; other site
451516004965	Switch I region; other site
451516004966	G2 box; other site
451516004967	G3 box; other site
451516004968	Switch II region; other site
451516004969	G4 box; other site
451516004970	G5 box; other site
451516004971	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
451516004972	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
451516004973	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
451516004974	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
451516004975	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
451516004976	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
451516004977	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
451516004978	rod shape-determining protein MreC; Region: MreC; pfam04085
451516004979	hypothetical protein; Reviewed; Region: PRK00024
451516004980	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
451516004981	MPN+ (JAMM) motif; other site
451516004982	Zinc-binding site [ion binding]; other site
451516004983	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
451516004984	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
451516004985	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
451516004986	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
451516004987	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
451516004988	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
451516004989	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
451516004990	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
451516004991	active site
451516004992	HIGH motif; other site
451516004993	nucleotide binding site [chemical binding]; other site
451516004994	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
451516004995	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
451516004996	active site
451516004997	KMSKS motif; other site
451516004998	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
451516004999	tRNA binding surface [nucleotide binding]; other site
451516005000	anticodon binding site; other site
451516005001	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
451516005002	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
451516005003	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
451516005004	Putative ammonia monooxygenase; Region: AmoA; pfam05145
451516005005	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
451516005006	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
451516005007	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
451516005008	inhibitor-cofactor binding pocket; inhibition site
451516005009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516005010	catalytic residue [active]
451516005011	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
451516005012	dimer interface [polypeptide binding]; other site
451516005013	active site
451516005014	Schiff base residues; other site
451516005015	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
451516005016	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
451516005017	active site
451516005018	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
451516005019	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
451516005020	domain interfaces; other site
451516005021	active site
451516005022	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755
451516005023	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
451516005024	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
451516005025	tRNA; other site
451516005026	putative tRNA binding site [nucleotide binding]; other site
451516005027	putative NADP binding site [chemical binding]; other site
451516005028	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
451516005029	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
451516005030	G1 box; other site
451516005031	GTP/Mg2+ binding site [chemical binding]; other site
451516005032	Switch I region; other site
451516005033	G2 box; other site
451516005034	G3 box; other site
451516005035	Switch II region; other site
451516005036	G4 box; other site
451516005037	G5 box; other site
451516005038	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
451516005039	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
451516005040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516005041	Walker A motif; other site
451516005042	ATP binding site [chemical binding]; other site
451516005043	Walker B motif; other site
451516005044	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
451516005045	trigger factor; Provisional; Region: tig; PRK01490
451516005046	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
451516005047	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
451516005048	lysine transporter; Provisional; Region: PRK10836
451516005049	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
451516005050	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
451516005051	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
451516005052	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
451516005053	active site
451516005054	dimer interface [polypeptide binding]; other site
451516005055	motif 1; other site
451516005056	motif 2; other site
451516005057	motif 3; other site
451516005058	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
451516005059	anticodon binding site; other site
451516005060	primosomal protein DnaI; Reviewed; Region: PRK08939
451516005061	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
451516005062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516005063	Walker A motif; other site
451516005064	ATP binding site [chemical binding]; other site
451516005065	Walker B motif; other site
451516005066	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
451516005067	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
451516005068	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
451516005069	ATP cone domain; Region: ATP-cone; pfam03477
451516005070	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
451516005071	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
451516005072	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
451516005073	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
451516005074	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
451516005075	CoA-binding site [chemical binding]; other site
451516005076	ATP-binding [chemical binding]; other site
451516005077	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
451516005078	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
451516005079	DNA binding site [nucleotide binding]
451516005080	catalytic residue [active]
451516005081	H2TH interface [polypeptide binding]; other site
451516005082	putative catalytic residues [active]
451516005083	turnover-facilitating residue; other site
451516005084	intercalation triad [nucleotide binding]; other site
451516005085	8OG recognition residue [nucleotide binding]; other site
451516005086	putative reading head residues; other site
451516005087	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
451516005088	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
451516005089	DNA polymerase I; Provisional; Region: PRK05755
451516005090	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
451516005091	active site
451516005092	metal binding site 1 [ion binding]; metal-binding site
451516005093	putative 5' ssDNA interaction site; other site
451516005094	metal binding site 3; metal-binding site
451516005095	metal binding site 2 [ion binding]; metal-binding site
451516005096	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
451516005097	putative DNA binding site [nucleotide binding]; other site
451516005098	putative metal binding site [ion binding]; other site
451516005099	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
451516005100	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
451516005101	active site
451516005102	DNA binding site [nucleotide binding]
451516005103	catalytic site [active]
451516005104	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
451516005105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
451516005106	dimer interface [polypeptide binding]; other site
451516005107	phosphorylation site [posttranslational modification]
451516005108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516005109	ATP binding site [chemical binding]; other site
451516005110	Mg2+ binding site [ion binding]; other site
451516005111	G-X-G motif; other site
451516005112	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
451516005113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516005114	active site
451516005115	phosphorylation site [posttranslational modification]
451516005116	intermolecular recognition site; other site
451516005117	dimerization interface [polypeptide binding]; other site
451516005118	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
451516005119	DNA binding site [nucleotide binding]
451516005120	isocitrate dehydrogenase; Reviewed; Region: PRK07006
451516005121	isocitrate dehydrogenase; Validated; Region: PRK07362
451516005122	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
451516005123	dimer interface [polypeptide binding]; other site
451516005124	Citrate synthase; Region: Citrate_synt; pfam00285
451516005125	active site
451516005126	citrylCoA binding site [chemical binding]; other site
451516005127	oxalacetate/citrate binding site [chemical binding]; other site
451516005128	coenzyme A binding site [chemical binding]; other site
451516005129	catalytic triad [active]
451516005130	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
451516005131	pyruvate kinase; Provisional; Region: PRK06354
451516005132	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
451516005133	domain interfaces; other site
451516005134	active site
451516005135	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
451516005136	6-phosphofructokinase; Provisional; Region: PRK03202
451516005137	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
451516005138	active site
451516005139	ADP/pyrophosphate binding site [chemical binding]; other site
451516005140	dimerization interface [polypeptide binding]; other site
451516005141	allosteric effector site; other site
451516005142	fructose-1,6-bisphosphate binding site; other site
451516005143	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
451516005144	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
451516005145	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
451516005146	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
451516005147	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
451516005148	Malic enzyme, N-terminal domain; Region: malic; pfam00390
451516005149	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
451516005150	putative NAD(P) binding site [chemical binding]; other site
451516005151	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
451516005152	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
451516005153	active site
451516005154	PHP Thumb interface [polypeptide binding]; other site
451516005155	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
451516005156	generic binding surface I; other site
451516005157	generic binding surface II; other site
451516005158	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
451516005159	DHH family; Region: DHH; pfam01368
451516005160	DHHA1 domain; Region: DHHA1; pfam02272
451516005161	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
451516005162	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
451516005163	DNA-binding site [nucleotide binding]; DNA binding site
451516005164	DRTGG domain; Region: DRTGG; pfam07085
451516005165	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
451516005166	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
451516005167	active site 2 [active]
451516005168	active site 1 [active]
451516005169	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
451516005170	Ligand Binding Site [chemical binding]; other site
451516005171	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
451516005172	metal-dependent hydrolase; Provisional; Region: PRK00685
451516005173	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
451516005174	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
451516005175	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
451516005176	active site
451516005177	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
451516005178	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
451516005179	hexamer interface [polypeptide binding]; other site
451516005180	ligand binding site [chemical binding]; other site
451516005181	putative active site [active]
451516005182	NAD(P) binding site [chemical binding]; other site
451516005183	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
451516005184	Ligand Binding Site [chemical binding]; other site
451516005185	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
451516005186	propionate/acetate kinase; Provisional; Region: PRK12379
451516005187	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
451516005188	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516005189	S-adenosylmethionine binding site [chemical binding]; other site
451516005190	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
451516005191	dimer interface [polypeptide binding]; other site
451516005192	catalytic triad [active]
451516005193	peroxidatic and resolving cysteines [active]
451516005194	hypothetical protein; Provisional; Region: PRK10621
451516005195	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
451516005196	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
451516005197	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
451516005198	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
451516005199	Ligand Binding Site [chemical binding]; other site
451516005200	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
451516005201	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
451516005202	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
451516005203	catalytic residue [active]
451516005204	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
451516005205	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
451516005206	GAF domain; Region: GAF_2; pfam13185
451516005207	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
451516005208	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
451516005209	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
451516005210	RNA binding surface [nucleotide binding]; other site
451516005211	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
451516005212	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
451516005213	active site
451516005214	catalytic site [active]
451516005215	OsmC-like protein; Region: OsmC; cl00767
451516005216	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
451516005217	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
451516005218	catalytic residue [active]
451516005219	D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327
451516005220	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
451516005221	ligand binding site [chemical binding]; other site
451516005222	NAD binding site [chemical binding]; other site
451516005223	dimerization interface [polypeptide binding]; other site
451516005224	catalytic site [active]
451516005225	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
451516005226	putative L-serine binding site [chemical binding]; other site
451516005227	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
451516005228	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516005229	motif II; other site
451516005230	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
451516005231	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
451516005232	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
451516005233	active site turn [active]
451516005234	phosphorylation site [posttranslational modification]
451516005235	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
451516005236	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
451516005237	protein binding site [polypeptide binding]; other site
451516005238	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
451516005239	catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395
451516005240	active site
451516005241	HIGH motif; other site
451516005242	dimer interface [polypeptide binding]; other site
451516005243	KMSKS motif; other site
451516005244	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
451516005245	RNA binding surface [nucleotide binding]; other site
451516005246	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
451516005247	Transglycosylase; Region: Transgly; pfam00912
451516005248	haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658
451516005249	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
451516005250	NEAr Transporter domain; Region: NEAT; smart00725
451516005251	NEAr Transporter domain; Region: NEAT; smart00725
451516005252	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
451516005253	heme-binding site [chemical binding]; other site
451516005254	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
451516005255	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
451516005256	Potassium binding sites [ion binding]; other site
451516005257	Cesium cation binding sites [ion binding]; other site
451516005258	acetyl-CoA synthetase; Provisional; Region: PRK04319
451516005259	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
451516005260	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
451516005261	active site
451516005262	acyl-activating enzyme (AAE) consensus motif; other site
451516005263	putative CoA binding site [chemical binding]; other site
451516005264	AMP binding site [chemical binding]; other site
451516005265	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
451516005266	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
451516005267	active site
451516005268	Zn binding site [ion binding]; other site
451516005269	catabolite control protein A; Region: ccpA; TIGR01481
451516005270	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
451516005271	DNA binding site [nucleotide binding]
451516005272	domain linker motif; other site
451516005273	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
451516005274	dimerization interface [polypeptide binding]; other site
451516005275	effector binding site; other site
451516005276	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
451516005277	Chorismate mutase type II; Region: CM_2; cl00693
451516005278	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
451516005279	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
451516005280	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
451516005281	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
451516005282	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
451516005283	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
451516005284	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
451516005285	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
451516005286	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
451516005287	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
451516005288	putative tRNA-binding site [nucleotide binding]; other site
451516005289	hypothetical protein; Provisional; Region: PRK13668
451516005290	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
451516005291	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
451516005292	catalytic residues [active]
451516005293	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
451516005294	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
451516005295	oligomer interface [polypeptide binding]; other site
451516005296	active site
451516005297	metal binding site [ion binding]; metal-binding site
451516005298	Predicted small secreted protein [Function unknown]; Region: COG5584
451516005299	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
451516005300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516005301	S-adenosylmethionine binding site [chemical binding]; other site
451516005302	Phosphotransferase enzyme family; Region: APH; pfam01636
451516005303	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
451516005304	active site
451516005305	substrate binding site [chemical binding]; other site
451516005306	ATP binding site [chemical binding]; other site
451516005307	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
451516005308	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
451516005309	homodimer interface [polypeptide binding]; other site
451516005310	substrate-cofactor binding pocket; other site
451516005311	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516005312	catalytic residue [active]
451516005313	dipeptidase PepV; Reviewed; Region: PRK07318
451516005314	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
451516005315	active site
451516005316	metal binding site [ion binding]; metal-binding site
451516005317	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
451516005318	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
451516005319	RNA binding surface [nucleotide binding]; other site
451516005320	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
451516005321	active site
451516005322	uracil binding [chemical binding]; other site
451516005323	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
451516005324	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
451516005325	HI0933-like protein; Region: HI0933_like; pfam03486
451516005326	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516005327	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
451516005328	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005329	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005330	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005331	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005332	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005333	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005334	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005335	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005336	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005337	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005338	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005339	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005340	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005341	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005342	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
451516005343	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
451516005344	active site residue [active]
451516005345	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
451516005346	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
451516005347	HIGH motif; other site
451516005348	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
451516005349	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
451516005350	active site
451516005351	KMSKS motif; other site
451516005352	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
451516005353	tRNA binding surface [nucleotide binding]; other site
451516005354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516005355	Major Facilitator Superfamily; Region: MFS_1; pfam07690
451516005356	putative substrate translocation pore; other site
451516005357	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
451516005358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516005359	S-adenosylmethionine binding site [chemical binding]; other site
451516005360	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516005361	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
451516005362	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
451516005363	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
451516005364	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
451516005365	homopentamer interface [polypeptide binding]; other site
451516005366	active site
451516005367	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
451516005368	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
451516005369	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
451516005370	dimerization interface [polypeptide binding]; other site
451516005371	active site
451516005372	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
451516005373	Lumazine binding domain; Region: Lum_binding; pfam00677
451516005374	Lumazine binding domain; Region: Lum_binding; pfam00677
451516005375	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
451516005376	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
451516005377	catalytic motif [active]
451516005378	Zn binding site [ion binding]; other site
451516005379	RibD C-terminal domain; Region: RibD_C; cl17279
451516005380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
451516005381	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
451516005382	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
451516005383	arsenical pump membrane protein; Provisional; Region: PRK15445
451516005384	transmembrane helices; other site
451516005385	Low molecular weight phosphatase family; Region: LMWPc; cd00115
451516005386	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
451516005387	active site
451516005388	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
451516005389	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
451516005390	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
451516005391	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
451516005392	DNA binding residues [nucleotide binding]
451516005393	CAAX protease self-immunity; Region: Abi; pfam02517
451516005394	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
451516005395	active site
451516005396	intersubunit interactions; other site
451516005397	catalytic residue [active]
451516005398	camphor resistance protein CrcB; Provisional; Region: PRK14201
451516005399	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
451516005400	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
451516005401	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
451516005402	active site
451516005403	catalytic tetrad [active]
451516005404	S-adenosylmethionine synthetase; Validated; Region: PRK05250
451516005405	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
451516005406	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
451516005407	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
451516005408	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
451516005409	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
451516005410	active site
451516005411	substrate-binding site [chemical binding]; other site
451516005412	metal-binding site [ion binding]
451516005413	ATP binding site [chemical binding]; other site
451516005414	Transposase IS200 like; Region: Y1_Tnp; pfam01797
451516005415	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
451516005416	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
451516005417	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
451516005418	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
451516005419	nudix motif; other site
451516005420	Haemolytic domain; Region: Haemolytic; pfam01809
451516005421	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
451516005422	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
451516005423	metal binding site [ion binding]; metal-binding site
451516005424	substrate binding pocket [chemical binding]; other site
451516005425	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
451516005426	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
451516005427	acyl-activating enzyme (AAE) consensus motif; other site
451516005428	putative AMP binding site [chemical binding]; other site
451516005429	putative active site [active]
451516005430	putative CoA binding site [chemical binding]; other site
451516005431	Excalibur calcium-binding domain; Region: Excalibur; smart00894
451516005432	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
451516005433	Protein of unknown function (DUF3969); Region: DUF3969; pfam13108
451516005434	Domain of unknown function (DUF955); Region: DUF955; pfam06114
451516005435	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
451516005436	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
451516005437	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
451516005438	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
451516005439	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
451516005440	HsdM N-terminal domain; Region: HsdM_N; pfam12161
451516005441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516005442	S-adenosylmethionine binding site [chemical binding]; other site
451516005443	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
451516005444	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
451516005445	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
451516005446	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
451516005447	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
451516005448	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
451516005449	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
451516005450	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
451516005451	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
451516005452	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
451516005453	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
451516005454	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
451516005455	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
451516005456	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516005457	Walker A/P-loop; other site
451516005458	ATP binding site [chemical binding]; other site
451516005459	Q-loop/lid; other site
451516005460	ABC transporter signature motif; other site
451516005461	Walker B; other site
451516005462	D-loop; other site
451516005463	H-loop/switch region; other site
451516005464	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
451516005465	active site
451516005466	catalytic triad [active]
451516005467	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
451516005468	Flavoprotein; Region: Flavoprotein; pfam02441
451516005469	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
451516005470	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
451516005471	active site
451516005472	zinc binding site [ion binding]; other site
451516005473	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
451516005474	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
451516005475	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
451516005476	lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731
451516005477	beta-channel forming cytolysin; Region: hlyII; TIGR01002
451516005478	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
451516005479	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
451516005480	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
451516005481	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
451516005482	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
451516005483	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
451516005484	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
451516005485	ferrochelatase; Provisional; Region: PRK12435
451516005486	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
451516005487	C-terminal domain interface [polypeptide binding]; other site
451516005488	active site
451516005489	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
451516005490	active site
451516005491	N-terminal domain interface [polypeptide binding]; other site
451516005492	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
451516005493	substrate binding site [chemical binding]; other site
451516005494	active site
451516005495	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
451516005496	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
451516005497	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
451516005498	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
451516005499	Walker A/P-loop; other site
451516005500	ATP binding site [chemical binding]; other site
451516005501	Q-loop/lid; other site
451516005502	ABC transporter signature motif; other site
451516005503	Walker B; other site
451516005504	D-loop; other site
451516005505	H-loop/switch region; other site
451516005506	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
451516005507	HIT family signature motif; other site
451516005508	catalytic residue [active]
451516005509	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
451516005510	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
451516005511	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
451516005512	SurA N-terminal domain; Region: SurA_N_3; cl07813
451516005513	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
451516005514	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
451516005515	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
451516005516	generic binding surface II; other site
451516005517	generic binding surface I; other site
451516005518	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
451516005519	Zn2+ binding site [ion binding]; other site
451516005520	Mg2+ binding site [ion binding]; other site
451516005521	Uncharacterized conserved protein [Function unknown]; Region: COG4717
451516005522	P-loop containing region of AAA domain; Region: AAA_29; cl17516
451516005523	Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273
451516005524	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
451516005525	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
451516005526	active site
451516005527	metal binding site [ion binding]; metal-binding site
451516005528	DNA binding site [nucleotide binding]
451516005529	hypothetical protein; Provisional; Region: PRK13676
451516005530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
451516005531	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
451516005532	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516005533	non-specific DNA binding site [nucleotide binding]; other site
451516005534	salt bridge; other site
451516005535	sequence-specific DNA binding site [nucleotide binding]; other site
451516005536	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
451516005537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516005538	active site
451516005539	phosphorylation site [posttranslational modification]
451516005540	intermolecular recognition site; other site
451516005541	dimerization interface [polypeptide binding]; other site
451516005542	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
451516005543	DNA binding residues [nucleotide binding]
451516005544	dimerization interface [polypeptide binding]; other site
451516005545	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
451516005546	GAF domain; Region: GAF_3; pfam13492
451516005547	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
451516005548	Histidine kinase; Region: HisKA_3; pfam07730
451516005549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516005550	ATP binding site [chemical binding]; other site
451516005551	Mg2+ binding site [ion binding]; other site
451516005552	G-X-G motif; other site
451516005553	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
451516005554	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
451516005555	active site
451516005556	fumarate hydratase; Reviewed; Region: fumC; PRK00485
451516005557	Class II fumarases; Region: Fumarase_classII; cd01362
451516005558	active site
451516005559	tetramer interface [polypeptide binding]; other site
451516005560	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
451516005561	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
451516005562	active site
451516005563	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
451516005564	epoxyqueuosine reductase; Region: TIGR00276
451516005565	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
451516005566	HEAT repeats; Region: HEAT_2; pfam13646
451516005567	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
451516005568	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
451516005569	Walker A/P-loop; other site
451516005570	ATP binding site [chemical binding]; other site
451516005571	Q-loop/lid; other site
451516005572	ABC transporter signature motif; other site
451516005573	Walker B; other site
451516005574	D-loop; other site
451516005575	H-loop/switch region; other site
451516005576	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
451516005577	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
451516005578	substrate binding pocket [chemical binding]; other site
451516005579	membrane-bound complex binding site; other site
451516005580	hinge residues; other site
451516005581	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
451516005582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516005583	dimer interface [polypeptide binding]; other site
451516005584	conserved gate region; other site
451516005585	putative PBP binding loops; other site
451516005586	ABC-ATPase subunit interface; other site
451516005587	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
451516005588	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
451516005589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
451516005590	Transposase; Region: DDE_Tnp_ISL3; pfam01610
451516005591	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
451516005592	metal binding site 2 [ion binding]; metal-binding site
451516005593	putative DNA binding helix; other site
451516005594	metal binding site 1 [ion binding]; metal-binding site
451516005595	dimer interface [polypeptide binding]; other site
451516005596	structural Zn2+ binding site [ion binding]; other site
451516005597	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
451516005598	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
451516005599	putative ligand binding site [chemical binding]; other site
451516005600	NAD binding site [chemical binding]; other site
451516005601	catalytic site [active]
451516005602	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
451516005603	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
451516005604	catalytic triad [active]
451516005605	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
451516005606	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
451516005607	inhibitor-cofactor binding pocket; inhibition site
451516005608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516005609	catalytic residue [active]
451516005610	Predicted membrane protein [Function unknown]; Region: COG4129
451516005611	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
451516005612	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
451516005613	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
451516005614	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
451516005615	Walker A/P-loop; other site
451516005616	ATP binding site [chemical binding]; other site
451516005617	Q-loop/lid; other site
451516005618	ABC transporter signature motif; other site
451516005619	Walker B; other site
451516005620	D-loop; other site
451516005621	H-loop/switch region; other site
451516005622	hypothetical protein; Provisional; Region: PRK13662
451516005623	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
451516005624	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
451516005625	minor groove reading motif; other site
451516005626	helix-hairpin-helix signature motif; other site
451516005627	substrate binding pocket [chemical binding]; other site
451516005628	active site
451516005629	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
451516005630	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
451516005631	DNA binding and oxoG recognition site [nucleotide binding]
451516005632	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
451516005633	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
451516005634	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516005635	Walker A/P-loop; other site
451516005636	ATP binding site [chemical binding]; other site
451516005637	Q-loop/lid; other site
451516005638	ABC transporter signature motif; other site
451516005639	Walker B; other site
451516005640	H-loop/switch region; other site
451516005641	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
451516005642	recombination regulator RecX; Provisional; Region: recX; PRK14135
451516005643	glycosyltransferase; Provisional; Region: PRK13481
451516005644	Transglycosylase; Region: Transgly; pfam00912
451516005645	intracellular protease, PfpI family; Region: PfpI; TIGR01382
451516005646	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
451516005647	proposed catalytic triad [active]
451516005648	conserved cys residue [active]
451516005649	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
451516005650	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516005651	FeS/SAM binding site; other site
451516005652	YfkB-like domain; Region: YfkB; pfam08756
451516005653	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
451516005654	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
451516005655	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
451516005656	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
451516005657	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
451516005658	Low molecular weight phosphatase family; Region: LMWPc; cd00115
451516005659	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
451516005660	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
451516005661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516005662	active site
451516005663	phosphorylation site [posttranslational modification]
451516005664	intermolecular recognition site; other site
451516005665	dimerization interface [polypeptide binding]; other site
451516005666	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
451516005667	DNA binding residues [nucleotide binding]
451516005668	dimerization interface [polypeptide binding]; other site
451516005669	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
451516005670	Histidine kinase; Region: HisKA_3; pfam07730
451516005671	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516005672	ATP binding site [chemical binding]; other site
451516005673	Mg2+ binding site [ion binding]; other site
451516005674	G-X-G motif; other site
451516005675	Predicted membrane protein [Function unknown]; Region: COG4758
451516005676	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
451516005677	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
451516005678	active site
451516005679	Predicted membrane protein [Function unknown]; Region: COG4129
451516005680	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
451516005681	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
451516005682	catalytic triad [active]
451516005683	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
451516005684	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
451516005685	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
451516005686	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
451516005687	Ferritin-like domain; Region: Ferritin; pfam00210
451516005688	ferroxidase diiron center [ion binding]; other site
451516005689	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
451516005690	active site
451516005691	catalytic site [active]
451516005692	substrate binding site [chemical binding]; other site
451516005693	DNA polymerase IV; Validated; Region: PRK02406
451516005694	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
451516005695	active site
451516005696	DNA binding site [nucleotide binding]
451516005697	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
451516005698	TRAM domain; Region: TRAM; cl01282
451516005699	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
451516005700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516005701	S-adenosylmethionine binding site [chemical binding]; other site
451516005702	putative lipid kinase; Reviewed; Region: PRK13337
451516005703	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
451516005704	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
451516005705	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
451516005706	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
451516005707	GatB domain; Region: GatB_Yqey; pfam02637
451516005708	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
451516005709	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
451516005710	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
451516005711	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
451516005712	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
451516005713	Na binding site [ion binding]; other site
451516005714	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
451516005715	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
451516005716	putative dimer interface [polypeptide binding]; other site
451516005717	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
451516005718	putative dimer interface [polypeptide binding]; other site
451516005719	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
451516005720	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
451516005721	nucleotide binding pocket [chemical binding]; other site
451516005722	K-X-D-G motif; other site
451516005723	catalytic site [active]
451516005724	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
451516005725	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
451516005726	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
451516005727	Dimer interface [polypeptide binding]; other site
451516005728	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
451516005729	Part of AAA domain; Region: AAA_19; pfam13245
451516005730	Family description; Region: UvrD_C_2; pfam13538
451516005731	PcrB family; Region: PcrB; pfam01884
451516005732	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
451516005733	substrate binding site [chemical binding]; other site
451516005734	putative active site [active]
451516005735	dimer interface [polypeptide binding]; other site
451516005736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
451516005737	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
451516005738	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
451516005739	tetramer interface [polypeptide binding]; other site
451516005740	active site
451516005741	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
451516005742	Staphopain peptidase C47; Region: Peptidase_C47; pfam05543
451516005743	Staphostatin A; Region: Staphostatin_A; pfam09022
451516005744	NETI protein; Region: NETI; pfam14044
451516005745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
451516005746	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
451516005747	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
451516005748	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
451516005749	homodimer interface [polypeptide binding]; other site
451516005750	NAD binding pocket [chemical binding]; other site
451516005751	ATP binding pocket [chemical binding]; other site
451516005752	Mg binding site [ion binding]; other site
451516005753	active-site loop [active]
451516005754	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
451516005755	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
451516005756	active site
451516005757	Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794
451516005758	active site
451516005759	dimer interface [polypeptide binding]; other site
451516005760	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
451516005761	Prephenate dehydratase; Region: PDT; pfam00800
451516005762	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
451516005763	putative L-Phe binding site [chemical binding]; other site
451516005764	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
451516005765	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
451516005766	transmembrane helices; other site
451516005767	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
451516005768	Isochorismatase family; Region: Isochorismatase; pfam00857
451516005769	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
451516005770	catalytic triad [active]
451516005771	conserved cis-peptide bond; other site
451516005772	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
451516005773	DHH family; Region: DHH; pfam01368
451516005774	DHHA2 domain; Region: DHHA2; pfam02833
451516005775	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
451516005776	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
451516005777	NAD(P) binding site [chemical binding]; other site
451516005778	catalytic residues [active]
451516005779	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
451516005780	YolD-like protein; Region: YolD; pfam08863
451516005781	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
451516005782	active site
451516005783	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
451516005784	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
451516005785	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
451516005786	Bacterial PH domain; Region: DUF304; cl01348
451516005787	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
451516005788	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
451516005789	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
451516005790	Walker A/P-loop; other site
451516005791	ATP binding site [chemical binding]; other site
451516005792	Q-loop/lid; other site
451516005793	ABC transporter signature motif; other site
451516005794	Walker B; other site
451516005795	D-loop; other site
451516005796	H-loop/switch region; other site
451516005797	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
451516005798	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
451516005799	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
451516005800	Walker A/P-loop; other site
451516005801	ATP binding site [chemical binding]; other site
451516005802	Q-loop/lid; other site
451516005803	ABC transporter signature motif; other site
451516005804	Walker B; other site
451516005805	D-loop; other site
451516005806	H-loop/switch region; other site
451516005807	Predicted transcriptional regulators [Transcription]; Region: COG1725
451516005808	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
451516005809	DNA-binding site [nucleotide binding]; DNA binding site
451516005810	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
451516005811	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
451516005812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516005813	homodimer interface [polypeptide binding]; other site
451516005814	catalytic residue [active]
451516005815	MAP domain; Region: MAP; pfam03642
451516005816	MAP domain; Region: MAP; pfam03642
451516005817	MAP domain; Region: MAP; pfam03642
451516005818	MAP domain; Region: MAP; pfam03642
451516005819	MAP domain; Region: MAP; pfam03642
451516005820	Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546
451516005821	chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032
451516005822	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
451516005823	CHAP domain; Region: CHAP; pfam05257
451516005824	Small integral membrane protein [Function unknown]; Region: COG5546
451516005825	Protein of unknown function (DUF2951); Region: DUF2951; pfam11166
451516005826	phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665
451516005827	TolA protein; Region: tolA_full; TIGR02794
451516005828	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
451516005829	Phage tail protein; Region: Sipho_tail; cl17486
451516005830	Phage tail protein; Region: Sipho_tail; cl17486
451516005831	Phage-related minor tail protein [Function unknown]; Region: COG5280
451516005832	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
451516005833	Phage-related protein [Function unknown]; Region: COG5412
451516005834	membrane protein P6; Region: PHA01399
451516005835	Peptidase family M23; Region: Peptidase_M23; pfam01551
451516005836	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
451516005837	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
451516005838	N-acetyl-D-glucosamine binding site [chemical binding]; other site
451516005839	catalytic residue [active]
451516005840	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
451516005841	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
451516005842	Translocation protein Sec62; Region: Sec62; cl02170
451516005843	Phage capsid family; Region: Phage_capsid; pfam05065
451516005844	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
451516005845	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
451516005846	oligomer interface [polypeptide binding]; other site
451516005847	active site residues [active]
451516005848	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
451516005849	Phage-related protein [Function unknown]; Region: COG4695; cl01923
451516005850	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
451516005851	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
451516005852	HNH endonuclease; Region: HNH; pfam01844
451516005853	active site
451516005854	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
451516005855	Protein of unknown function (DUF1514); Region: DUF1514; pfam07438
451516005856	Transcriptional activator RinB; Region: RinB; pfam06116
451516005857	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
451516005858	Protein of unknown function (DUF1381); Region: DUF1381; pfam07129
451516005859	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
451516005860	trimer interface [polypeptide binding]; other site
451516005861	active site
451516005862	Protein of unknown function (DUF1024); Region: DUF1024; pfam06260
451516005863	Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194
451516005864	PVL ORF-50-like family; Region: PVL_ORF50; pfam07768
451516005865	Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570
451516005866	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
451516005867	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
451516005868	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
451516005869	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
451516005870	dimer interface [polypeptide binding]; other site
451516005871	ssDNA binding site [nucleotide binding]; other site
451516005872	tetramer (dimer of dimers) interface [polypeptide binding]; other site
451516005873	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
451516005874	RecT family; Region: RecT; pfam03837
451516005875	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
451516005876	Protein of unknown function (DUF1108); Region: DUF1108; pfam06531
451516005877	Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655
451516005878	Protein of unknown function (DUF1270); Region: DUF1270; pfam06900
451516005879	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707
451516005880	Phage anti-repressor protein [Transcription]; Region: COG3561
451516005881	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
451516005882	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
451516005883	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
451516005884	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
451516005885	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516005886	non-specific DNA binding site [nucleotide binding]; other site
451516005887	salt bridge; other site
451516005888	sequence-specific DNA binding site [nucleotide binding]; other site
451516005889	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
451516005890	non-specific DNA binding site [nucleotide binding]; other site
451516005891	salt bridge; other site
451516005892	sequence-specific DNA binding site [nucleotide binding]; other site
451516005893	Predicted transcriptional regulator [Transcription]; Region: COG2932
451516005894	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
451516005895	Catalytic site [active]
451516005896	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
451516005897	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
451516005898	active site
451516005899	catalytic site [active]
451516005900	substrate binding site [chemical binding]; other site
451516005901	PemK-like protein; Region: PemK; pfam02452
451516005902	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
451516005903	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
451516005904	Int/Topo IB signature motif; other site
451516005905	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
451516005906	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
451516005907	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
451516005908	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
451516005909	metal binding site [ion binding]; metal-binding site
451516005910	dimer interface [polypeptide binding]; other site
451516005911	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
451516005912	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
451516005913	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
451516005914	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
451516005915	putative ligand binding residues [chemical binding]; other site
451516005916	Cation transport protein; Region: TrkH; cl17365
451516005917	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
451516005918	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516005919	Coenzyme A binding pocket [chemical binding]; other site
451516005920	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
451516005921	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
451516005922	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
451516005923	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
451516005924	ring oligomerisation interface [polypeptide binding]; other site
451516005925	ATP/Mg binding site [chemical binding]; other site
451516005926	stacking interactions; other site
451516005927	hinge regions; other site
451516005928	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
451516005929	oligomerisation interface [polypeptide binding]; other site
451516005930	mobile loop; other site
451516005931	roof hairpin; other site
451516005932	CAAX protease self-immunity; Region: Abi; pfam02517
451516005933	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
451516005934	dimer interface [polypeptide binding]; other site
451516005935	FMN binding site [chemical binding]; other site
451516005936	Predicted amidohydrolase [General function prediction only]; Region: COG0388
451516005937	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
451516005938	putative active site [active]
451516005939	catalytic triad [active]
451516005940	putative dimer interface [polypeptide binding]; other site
451516005941	delta-hemolysin; Provisional; Region: PRK14752
451516005942	Accessory gene regulator B; Region: AgrB; smart00793
451516005943	Staphylococcal AgrD protein; Region: AgrD; smart00794
451516005944	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
451516005945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516005946	Mg2+ binding site [ion binding]; other site
451516005947	G-X-G motif; other site
451516005948	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
451516005949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516005950	active site
451516005951	phosphorylation site [posttranslational modification]
451516005952	intermolecular recognition site; other site
451516005953	dimerization interface [polypeptide binding]; other site
451516005954	LytTr DNA-binding domain; Region: LytTR; pfam04397
451516005955	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
451516005956	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
451516005957	putative substrate binding site [chemical binding]; other site
451516005958	putative ATP binding site [chemical binding]; other site
451516005959	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
451516005960	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
451516005961	substrate binding [chemical binding]; other site
451516005962	active site
451516005963	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
451516005964	Transcriptional regulators [Transcription]; Region: PurR; COG1609
451516005965	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
451516005966	DNA binding site [nucleotide binding]
451516005967	domain linker motif; other site
451516005968	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
451516005969	dimerization interface [polypeptide binding]; other site
451516005970	ligand binding site [chemical binding]; other site
451516005971	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
451516005972	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
451516005973	CPxP  motif; other site
451516005974	Predicted transporter component [General function prediction only]; Region: COG2391
451516005975	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
451516005976	Sulphur transport; Region: Sulf_transp; pfam04143
451516005977	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
451516005978	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
451516005979	Walker A/P-loop; other site
451516005980	ATP binding site [chemical binding]; other site
451516005981	Q-loop/lid; other site
451516005982	ABC transporter signature motif; other site
451516005983	Walker B; other site
451516005984	D-loop; other site
451516005985	H-loop/switch region; other site
451516005986	UGMP family protein; Validated; Region: PRK09604
451516005987	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
451516005988	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
451516005989	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516005990	Coenzyme A binding pocket [chemical binding]; other site
451516005991	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
451516005992	Glycoprotease family; Region: Peptidase_M22; pfam00814
451516005993	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
451516005994	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
451516005995	6-phosphogluconate dehydratase; Region: edd; TIGR01196
451516005996	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
451516005997	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
451516005998	PYR/PP interface [polypeptide binding]; other site
451516005999	dimer interface [polypeptide binding]; other site
451516006000	TPP binding site [chemical binding]; other site
451516006001	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
451516006002	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
451516006003	TPP-binding site [chemical binding]; other site
451516006004	dimer interface [polypeptide binding]; other site
451516006005	acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562
451516006006	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
451516006007	ketol-acid reductoisomerase; Provisional; Region: PRK05479
451516006008	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
451516006009	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
451516006010	2-isopropylmalate synthase; Validated; Region: PRK00915
451516006011	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
451516006012	active site
451516006013	catalytic residues [active]
451516006014	metal binding site [ion binding]; metal-binding site
451516006015	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
451516006016	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
451516006017	tartrate dehydrogenase; Region: TTC; TIGR02089
451516006018	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
451516006019	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
451516006020	substrate binding site [chemical binding]; other site
451516006021	ligand binding site [chemical binding]; other site
451516006022	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
451516006023	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
451516006024	substrate binding site [chemical binding]; other site
451516006025	threonine dehydratase; Validated; Region: PRK08639
451516006026	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
451516006027	tetramer interface [polypeptide binding]; other site
451516006028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516006029	catalytic residue [active]
451516006030	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
451516006031	putative Ile/Val binding site [chemical binding]; other site
451516006032	hypothetical protein; Provisional; Region: PRK04351
451516006033	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
451516006034	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
451516006035	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
451516006036	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
451516006037	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
451516006038	RNA binding site [nucleotide binding]; other site
451516006039	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
451516006040	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
451516006041	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
451516006042	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
451516006043	DNA binding residues [nucleotide binding]
451516006044	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
451516006045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516006046	ATP binding site [chemical binding]; other site
451516006047	Mg2+ binding site [ion binding]; other site
451516006048	G-X-G motif; other site
451516006049	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
451516006050	anti sigma factor interaction site; other site
451516006051	regulatory phosphorylation site [posttranslational modification]; other site
451516006052	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
451516006053	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
451516006054	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
451516006055	PemK-like protein; Region: PemK; pfam02452
451516006056	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
451516006057	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
451516006058	active site
451516006059	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
451516006060	dimer interface [polypeptide binding]; other site
451516006061	substrate binding site [chemical binding]; other site
451516006062	catalytic residues [active]
451516006063	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
451516006064	Uncharacterized conserved protein [Function unknown]; Region: COG3402
451516006065	Predicted membrane protein [Function unknown]; Region: COG3428
451516006066	Bacterial PH domain; Region: DUF304; pfam03703
451516006067	Bacterial PH domain; Region: DUF304; pfam03703
451516006068	Bacterial PH domain; Region: DUF304; cl01348
451516006069	potassium-transporting ATPase subunit C; Provisional; Region: PRK13998
451516006070	High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216
451516006071	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
451516006072	Soluble P-type ATPase [General function prediction only]; Region: COG4087
451516006073	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
451516006074	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
451516006075	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
451516006076	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
451516006077	Ligand Binding Site [chemical binding]; other site
451516006078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
451516006079	dimer interface [polypeptide binding]; other site
451516006080	phosphorylation site [posttranslational modification]
451516006081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516006082	ATP binding site [chemical binding]; other site
451516006083	Mg2+ binding site [ion binding]; other site
451516006084	G-X-G motif; other site
451516006085	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
451516006086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516006087	active site
451516006088	phosphorylation site [posttranslational modification]
451516006089	intermolecular recognition site; other site
451516006090	dimerization interface [polypeptide binding]; other site
451516006091	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
451516006092	DNA binding site [nucleotide binding]
451516006093	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
451516006094	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
451516006095	ATP binding site [chemical binding]; other site
451516006096	Mg++ binding site [ion binding]; other site
451516006097	motif III; other site
451516006098	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
451516006099	nucleotide binding region [chemical binding]; other site
451516006100	ATP-binding site [chemical binding]; other site
451516006101	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
451516006102	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
451516006103	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
451516006104	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
451516006105	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
451516006106	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
451516006107	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
451516006108	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
451516006109	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
451516006110	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
451516006111	putative homodimer interface [polypeptide binding]; other site
451516006112	putative homotetramer interface [polypeptide binding]; other site
451516006113	allosteric switch controlling residues; other site
451516006114	putative metal binding site [ion binding]; other site
451516006115	putative homodimer-homodimer interface [polypeptide binding]; other site
451516006116	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
451516006117	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
451516006118	putative active site [active]
451516006119	catalytic site [active]
451516006120	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
451516006121	putative active site [active]
451516006122	catalytic site [active]
451516006123	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
451516006124	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
451516006125	Zn2+ binding site [ion binding]; other site
451516006126	Mg2+ binding site [ion binding]; other site
451516006127	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
451516006128	YwpF-like protein; Region: YwpF; pfam14183
451516006129	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
451516006130	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
451516006131	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
451516006132	hinge; other site
451516006133	active site
451516006134	Predicted membrane protein [Function unknown]; Region: COG4836
451516006135	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735
451516006136	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
451516006137	gamma subunit interface [polypeptide binding]; other site
451516006138	epsilon subunit interface [polypeptide binding]; other site
451516006139	LBP interface [polypeptide binding]; other site
451516006140	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
451516006141	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
451516006142	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
451516006143	alpha subunit interaction interface [polypeptide binding]; other site
451516006144	Walker A motif; other site
451516006145	ATP binding site [chemical binding]; other site
451516006146	Walker B motif; other site
451516006147	inhibitor binding site; inhibition site
451516006148	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
451516006149	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
451516006150	core domain interface [polypeptide binding]; other site
451516006151	delta subunit interface [polypeptide binding]; other site
451516006152	epsilon subunit interface [polypeptide binding]; other site
451516006153	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
451516006154	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
451516006155	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
451516006156	beta subunit interaction interface [polypeptide binding]; other site
451516006157	Walker A motif; other site
451516006158	ATP binding site [chemical binding]; other site
451516006159	Walker B motif; other site
451516006160	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
451516006161	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
451516006162	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
451516006163	F0F1 ATP synthase subunit B; Provisional; Region: PRK13453
451516006164	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
451516006165	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
451516006166	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
451516006167	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
451516006168	Bacterial ATP synthase I; Region: Bac_ATP_syn_I; pfam05468
451516006169	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
451516006170	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
451516006171	active site
451516006172	homodimer interface [polypeptide binding]; other site
451516006173	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
451516006174	active site
451516006175	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
451516006176	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
451516006177	dimer interface [polypeptide binding]; other site
451516006178	active site
451516006179	glycine-pyridoxal phosphate binding site [chemical binding]; other site
451516006180	folate binding site [chemical binding]; other site
451516006181	hypothetical protein; Provisional; Region: PRK13690
451516006182	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
451516006183	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516006184	S-adenosylmethionine binding site [chemical binding]; other site
451516006185	peptide chain release factor 1; Validated; Region: prfA; PRK00591
451516006186	This domain is found in peptide chain release factors; Region: PCRF; smart00937
451516006187	RF-1 domain; Region: RF-1; pfam00472
451516006188	thymidine kinase; Provisional; Region: PRK04296
451516006189	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
451516006190	transcription termination factor Rho; Provisional; Region: rho; PRK09376
451516006191	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
451516006192	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
451516006193	RNA binding site [nucleotide binding]; other site
451516006194	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
451516006195	multimer interface [polypeptide binding]; other site
451516006196	Walker A motif; other site
451516006197	ATP binding site [chemical binding]; other site
451516006198	Walker B motif; other site
451516006199	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
451516006200	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
451516006201	NAD binding site [chemical binding]; other site
451516006202	catalytic residues [active]
451516006203	Predicted transcriptional regulators [Transcription]; Region: COG1733
451516006204	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
451516006205	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
451516006206	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
451516006207	hinge; other site
451516006208	active site
451516006209	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
451516006210	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
451516006211	intersubunit interface [polypeptide binding]; other site
451516006212	active site
451516006213	zinc binding site [ion binding]; other site
451516006214	Na+ binding site [ion binding]; other site
451516006215	Protein of unknown function (DUF2529); Region: DUF2529; pfam10740
451516006216	CTP synthetase; Validated; Region: pyrG; PRK05380
451516006217	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
451516006218	Catalytic site [active]
451516006219	active site
451516006220	UTP binding site [chemical binding]; other site
451516006221	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
451516006222	active site
451516006223	putative oxyanion hole; other site
451516006224	catalytic triad [active]
451516006225	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
451516006226	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
451516006227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516006228	Coenzyme A binding pocket [chemical binding]; other site
451516006229	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
451516006230	pantothenate kinase; Provisional; Region: PRK13317
451516006231	pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555
451516006232	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
451516006233	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
451516006234	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
451516006235	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
451516006236	metal binding site [ion binding]; metal-binding site
451516006237	S-ribosylhomocysteinase; Provisional; Region: PRK02260
451516006238	Predicted membrane protein [Function unknown]; Region: COG4270
451516006239	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
451516006240	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
451516006241	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
451516006242	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
451516006243	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
451516006244	intersubunit interface [polypeptide binding]; other site
451516006245	active site
451516006246	catalytic residue [active]
451516006247	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
451516006248	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
451516006249	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
451516006250	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
451516006251	dimerization interface [polypeptide binding]; other site
451516006252	DPS ferroxidase diiron center [ion binding]; other site
451516006253	ion pore; other site
451516006254	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
451516006255	EVE domain; Region: EVE; cl00728
451516006256	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
451516006257	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
451516006258	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
451516006259	NADH(P)-binding; Region: NAD_binding_10; pfam13460
451516006260	NAD(P) binding site [chemical binding]; other site
451516006261	putative active site [active]
451516006262	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
451516006263	dimerization interface [polypeptide binding]; other site
451516006264	putative DNA binding site [nucleotide binding]; other site
451516006265	putative Zn2+ binding site [ion binding]; other site
451516006266	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
451516006267	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
451516006268	SAP domain; Region: SAP; pfam02037
451516006269	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
451516006270	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516006271	active site
451516006272	motif I; other site
451516006273	motif II; other site
451516006274	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516006275	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
451516006276	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516006277	Walker A/P-loop; other site
451516006278	ATP binding site [chemical binding]; other site
451516006279	Q-loop/lid; other site
451516006280	ABC transporter signature motif; other site
451516006281	Walker B; other site
451516006282	D-loop; other site
451516006283	H-loop/switch region; other site
451516006284	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
451516006285	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
451516006286	glutaminase active site [active]
451516006287	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
451516006288	dimer interface [polypeptide binding]; other site
451516006289	active site
451516006290	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
451516006291	dimer interface [polypeptide binding]; other site
451516006292	active site
451516006293	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
451516006294	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
451516006295	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
451516006296	active site
451516006297	P-loop; other site
451516006298	phosphorylation site [posttranslational modification]
451516006299	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
451516006300	HTH domain; Region: HTH_11; pfam08279
451516006301	Mga helix-turn-helix domain; Region: Mga; pfam05043
451516006302	PRD domain; Region: PRD; pfam00874
451516006303	PRD domain; Region: PRD; pfam00874
451516006304	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
451516006305	active site
451516006306	P-loop; other site
451516006307	phosphorylation site [posttranslational modification]
451516006308	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
451516006309	active site
451516006310	phosphorylation site [posttranslational modification]
451516006311	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
451516006312	active site
451516006313	phosphorylation site [posttranslational modification]
451516006314	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
451516006315	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
451516006316	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
451516006317	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
451516006318	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
451516006319	active site
451516006320	substrate binding site [chemical binding]; other site
451516006321	metal binding site [ion binding]; metal-binding site
451516006322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
451516006323	YbbR-like protein; Region: YbbR; pfam07949
451516006324	TIGR00159 family protein; Region: TIGR00159
451516006325	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
451516006326	Arginase family; Region: Arginase; cd09989
451516006327	active site
451516006328	Mn binding site [ion binding]; other site
451516006329	oligomer interface [polypeptide binding]; other site
451516006330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
451516006331	Transposase; Region: DDE_Tnp_ISL3; pfam01610
451516006332	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
451516006333	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
451516006334	Walker A motif; other site
451516006335	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006336	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
451516006337	putative substrate translocation pore; other site
451516006338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006339	Major Facilitator Superfamily; Region: MFS_1; pfam07690
451516006340	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006341	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
451516006342	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
451516006343	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
451516006344	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
451516006345	substrate binding site; other site
451516006346	dimerization interface; other site
451516006347	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
451516006348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
451516006349	Nucleoside recognition; Region: Gate; pfam07670
451516006350	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
451516006351	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516006352	ABC-ATPase subunit  interface; other site
451516006353	dimer interface [polypeptide binding]; other site
451516006354	putative PBP binding regions; other site
451516006355	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
451516006356	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
451516006357	ABC-ATPase subunit  interface; other site
451516006358	dimer interface [polypeptide binding]; other site
451516006359	putative PBP binding regions; other site
451516006360	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
451516006361	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
451516006362	siderophore binding site; other site
451516006363	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
451516006364	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
451516006365	dimer interface [polypeptide binding]; other site
451516006366	active site
451516006367	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
451516006368	substrate binding site [chemical binding]; other site
451516006369	catalytic residue [active]
451516006370	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
451516006371	IucA / IucC family; Region: IucA_IucC; pfam04183
451516006372	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
451516006373	H+ Antiporter protein; Region: 2A0121; TIGR00900
451516006374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006375	putative substrate translocation pore; other site
451516006376	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
451516006377	IucA / IucC family; Region: IucA_IucC; pfam04183
451516006378	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
451516006379	Asp23 family; Region: Asp23; pfam03780
451516006380	Small integral membrane protein [Function unknown]; Region: COG5547
451516006381	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
451516006382	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
451516006383	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
451516006384	putative NAD(P) binding site [chemical binding]; other site
451516006385	dimer interface [polypeptide binding]; other site
451516006386	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
451516006387	Prostaglandin dehydrogenases; Region: PGDH; cd05288
451516006388	NAD(P) binding site [chemical binding]; other site
451516006389	substrate binding site [chemical binding]; other site
451516006390	dimer interface [polypeptide binding]; other site
451516006391	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
451516006392	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
451516006393	beta-galactosidase; Region: BGL; TIGR03356
451516006394	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
451516006395	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
451516006396	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
451516006397	active site
451516006398	P-loop; other site
451516006399	phosphorylation site [posttranslational modification]
451516006400	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
451516006401	methionine cluster; other site
451516006402	active site
451516006403	phosphorylation site [posttranslational modification]
451516006404	metal binding site [ion binding]; metal-binding site
451516006405	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
451516006406	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
451516006407	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
451516006408	putative substrate binding site [chemical binding]; other site
451516006409	putative ATP binding site [chemical binding]; other site
451516006410	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
451516006411	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
451516006412	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
451516006413	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
451516006414	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
451516006415	NAD-dependent deacetylase; Provisional; Region: PRK00481
451516006416	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
451516006417	NAD+ binding site [chemical binding]; other site
451516006418	substrate binding site [chemical binding]; other site
451516006419	putative Zn binding site [ion binding]; other site
451516006420	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
451516006421	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
451516006422	active site
451516006423	catalytic tetrad [active]
451516006424	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
451516006425	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
451516006426	DNA binding residues [nucleotide binding]
451516006427	putative dimer interface [polypeptide binding]; other site
451516006428	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
451516006429	substrate binding site [chemical binding]; other site
451516006430	catalytic residues [active]
451516006431	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
451516006432	Peptidase family M23; Region: Peptidase_M23; pfam01551
451516006433	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
451516006434	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
451516006435	active site
451516006436	motif I; other site
451516006437	motif II; other site
451516006438	MAP domain; Region: MAP; pfam03642
451516006439	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
451516006440	acetolactate synthase; Reviewed; Region: PRK08617
451516006441	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
451516006442	PYR/PP interface [polypeptide binding]; other site
451516006443	dimer interface [polypeptide binding]; other site
451516006444	TPP binding site [chemical binding]; other site
451516006445	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
451516006446	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
451516006447	TPP-binding site [chemical binding]; other site
451516006448	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
451516006449	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516006450	Walker A motif; other site
451516006451	ATP binding site [chemical binding]; other site
451516006452	Walker B motif; other site
451516006453	arginine finger; other site
451516006454	Predicted helicase [General function prediction only]; Region: COG4889
451516006455	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
451516006456	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
451516006457	23S rRNA interface [nucleotide binding]; other site
451516006458	L3 interface [polypeptide binding]; other site
451516006459	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
451516006460	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
451516006461	dimerization interface 3.5A [polypeptide binding]; other site
451516006462	active site
451516006463	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
451516006464	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646
451516006465	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
451516006466	Walker A/P-loop; other site
451516006467	ATP binding site [chemical binding]; other site
451516006468	Q-loop/lid; other site
451516006469	ABC transporter signature motif; other site
451516006470	Walker B; other site
451516006471	D-loop; other site
451516006472	H-loop/switch region; other site
451516006473	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648
451516006474	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
451516006475	Walker A/P-loop; other site
451516006476	ATP binding site [chemical binding]; other site
451516006477	Q-loop/lid; other site
451516006478	ABC transporter signature motif; other site
451516006479	Walker B; other site
451516006480	D-loop; other site
451516006481	H-loop/switch region; other site
451516006482	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
451516006483	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
451516006484	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
451516006485	alphaNTD homodimer interface [polypeptide binding]; other site
451516006486	alphaNTD - beta interaction site [polypeptide binding]; other site
451516006487	alphaNTD - beta' interaction site [polypeptide binding]; other site
451516006488	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
451516006489	30S ribosomal protein S11; Validated; Region: PRK05309
451516006490	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
451516006491	30S ribosomal protein S13; Region: bact_S13; TIGR03631
451516006492	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
451516006493	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
451516006494	rRNA binding site [nucleotide binding]; other site
451516006495	predicted 30S ribosome binding site; other site
451516006496	adenylate kinase; Reviewed; Region: adk; PRK00279
451516006497	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
451516006498	AMP-binding site [chemical binding]; other site
451516006499	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
451516006500	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
451516006501	SecY translocase; Region: SecY; pfam00344
451516006502	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
451516006503	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
451516006504	23S rRNA binding site [nucleotide binding]; other site
451516006505	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
451516006506	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
451516006507	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
451516006508	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
451516006509	5S rRNA interface [nucleotide binding]; other site
451516006510	L27 interface [polypeptide binding]; other site
451516006511	23S rRNA interface [nucleotide binding]; other site
451516006512	L5 interface [polypeptide binding]; other site
451516006513	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
451516006514	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
451516006515	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
451516006516	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
451516006517	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
451516006518	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
451516006519	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
451516006520	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
451516006521	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
451516006522	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
451516006523	RNA binding site [nucleotide binding]; other site
451516006524	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
451516006525	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
451516006526	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
451516006527	23S rRNA interface [nucleotide binding]; other site
451516006528	putative translocon interaction site; other site
451516006529	signal recognition particle (SRP54) interaction site; other site
451516006530	L23 interface [polypeptide binding]; other site
451516006531	trigger factor interaction site; other site
451516006532	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
451516006533	23S rRNA interface [nucleotide binding]; other site
451516006534	5S rRNA interface [nucleotide binding]; other site
451516006535	putative antibiotic binding site [chemical binding]; other site
451516006536	L25 interface [polypeptide binding]; other site
451516006537	L27 interface [polypeptide binding]; other site
451516006538	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
451516006539	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
451516006540	G-X-X-G motif; other site
451516006541	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
451516006542	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
451516006543	putative translocon binding site; other site
451516006544	protein-rRNA interface [nucleotide binding]; other site
451516006545	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
451516006546	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
451516006547	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
451516006548	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
451516006549	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
451516006550	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
451516006551	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
451516006552	DNA topoisomerase III; Provisional; Region: PRK07726
451516006553	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
451516006554	active site
451516006555	putative interdomain interaction site [polypeptide binding]; other site
451516006556	putative metal-binding site [ion binding]; other site
451516006557	putative nucleotide binding site [chemical binding]; other site
451516006558	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
451516006559	domain I; other site
451516006560	DNA binding groove [nucleotide binding]
451516006561	phosphate binding site [ion binding]; other site
451516006562	domain II; other site
451516006563	domain III; other site
451516006564	nucleotide binding site [chemical binding]; other site
451516006565	catalytic site [active]
451516006566	domain IV; other site
451516006567	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
451516006568	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516006569	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
451516006570	Coenzyme A binding pocket [chemical binding]; other site
451516006571	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
451516006572	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
451516006573	Predicted permeases [General function prediction only]; Region: COG0679
451516006574	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
451516006575	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
451516006576	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
451516006577	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
451516006578	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
451516006579	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006580	Major Facilitator Superfamily; Region: MFS_1; pfam07690
451516006581	putative substrate translocation pore; other site
451516006582	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516006583	Transcriptional regulators [Transcription]; Region: MarR; COG1846
451516006584	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
451516006585	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516006586	FeS/SAM binding site; other site
451516006587	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
451516006588	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
451516006589	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
451516006590	GTP binding site; other site
451516006591	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
451516006592	MoaE interaction surface [polypeptide binding]; other site
451516006593	MoeB interaction surface [polypeptide binding]; other site
451516006594	thiocarboxylated glycine; other site
451516006595	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
451516006596	MoaE homodimer interface [polypeptide binding]; other site
451516006597	MoaD interaction [polypeptide binding]; other site
451516006598	active site residues [active]
451516006599	Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763
451516006600	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
451516006601	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
451516006602	dimer interface [polypeptide binding]; other site
451516006603	putative functional site; other site
451516006604	putative MPT binding site; other site
451516006605	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
451516006606	trimer interface [polypeptide binding]; other site
451516006607	dimer interface [polypeptide binding]; other site
451516006608	putative active site [active]
451516006609	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
451516006610	MPT binding site; other site
451516006611	trimer interface [polypeptide binding]; other site
451516006612	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
451516006613	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
451516006614	ATP binding site [chemical binding]; other site
451516006615	substrate interface [chemical binding]; other site
451516006616	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516006617	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
451516006618	Walker A/P-loop; other site
451516006619	ATP binding site [chemical binding]; other site
451516006620	Q-loop/lid; other site
451516006621	ABC transporter signature motif; other site
451516006622	Walker B; other site
451516006623	D-loop; other site
451516006624	H-loop/switch region; other site
451516006625	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
451516006626	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516006627	dimer interface [polypeptide binding]; other site
451516006628	conserved gate region; other site
451516006629	putative PBP binding loops; other site
451516006630	ABC-ATPase subunit interface; other site
451516006631	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
451516006632	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
451516006633	substrate binding pocket [chemical binding]; other site
451516006634	membrane-bound complex binding site; other site
451516006635	hinge residues; other site
451516006636	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
451516006637	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516006638	Coenzyme A binding pocket [chemical binding]; other site
451516006639	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
451516006640	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
451516006641	active site
451516006642	dimerization interface [polypeptide binding]; other site
451516006643	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
451516006644	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
451516006645	intersubunit interface [polypeptide binding]; other site
451516006646	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
451516006647	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
451516006648	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
451516006649	Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413
451516006650	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
451516006651	alpha-gamma subunit interface [polypeptide binding]; other site
451516006652	beta-gamma subunit interface [polypeptide binding]; other site
451516006653	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
451516006654	gamma-beta subunit interface [polypeptide binding]; other site
451516006655	alpha-beta subunit interface [polypeptide binding]; other site
451516006656	urease subunit alpha; Reviewed; Region: ureC; PRK13207
451516006657	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
451516006658	subunit interactions [polypeptide binding]; other site
451516006659	active site
451516006660	flap region; other site
451516006661	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
451516006662	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
451516006663	dimer interface [polypeptide binding]; other site
451516006664	catalytic residues [active]
451516006665	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
451516006666	UreF; Region: UreF; pfam01730
451516006667	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
451516006668	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
451516006669	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516006670	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516006671	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516006672	Helix-turn-helix domain; Region: HTH_18; pfam12833
451516006673	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
451516006674	Surface antigen [General function prediction only]; Region: COG3942
451516006675	CHAP domain; Region: CHAP; pfam05257
451516006676	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
451516006677	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
451516006678	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
451516006679	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
451516006680	Surface antigen [General function prediction only]; Region: COG3942
451516006681	CHAP domain; Region: CHAP; pfam05257
451516006682	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
451516006683	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
451516006684	putative ligand binding site [chemical binding]; other site
451516006685	putative NAD binding site [chemical binding]; other site
451516006686	catalytic site [active]
451516006687	hypothetical protein; Provisional; Region: PRK06753
451516006688	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
451516006689	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
451516006690	Lysozyme subfamily 2; Region: LYZ2; smart00047
451516006691	Uncharacterized conserved protein [Function unknown]; Region: COG2427
451516006692	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
451516006693	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
451516006694	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
451516006695	4Fe-4S binding domain; Region: Fer4; pfam00037
451516006696	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
451516006697	[4Fe-4S] binding site [ion binding]; other site
451516006698	molybdopterin cofactor binding site; other site
451516006699	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
451516006700	molybdopterin cofactor binding site; other site
451516006701	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
451516006702	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
451516006703	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
451516006704	active site
451516006705	Predicted transcriptional regulator [Transcription]; Region: COG2378
451516006706	HTH domain; Region: HTH_11; pfam08279
451516006707	CAAX protease self-immunity; Region: Abi; pfam02517
451516006708	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
451516006709	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
451516006710	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
451516006711	putative active site [active]
451516006712	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
451516006713	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
451516006714	Sodium Bile acid symporter family; Region: SBF; pfam01758
451516006715	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
451516006716	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
451516006717	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
451516006718	active site turn [active]
451516006719	phosphorylation site [posttranslational modification]
451516006720	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
451516006721	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
451516006722	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
451516006723	putative active site [active]
451516006724	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
451516006725	putative hydrophobic ligand binding site [chemical binding]; other site
451516006726	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
451516006727	oxidoreductase; Provisional; Region: PRK07985
451516006728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
451516006729	NAD(P) binding site [chemical binding]; other site
451516006730	active site
451516006731	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
451516006732	amidohydrolase; Region: amidohydrolases; TIGR01891
451516006733	metal binding site [ion binding]; metal-binding site
451516006734	dimer interface [polypeptide binding]; other site
451516006735	imidazolonepropionase; Validated; Region: PRK09356
451516006736	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
451516006737	active site
451516006738	urocanate hydratase; Provisional; Region: PRK05414
451516006739	Transcriptional regulator [Transcription]; Region: LysR; COG0583
451516006740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
451516006741	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
451516006742	dimerization interface [polypeptide binding]; other site
451516006743	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
451516006744	FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363
451516006745	putative active site [active]
451516006746	putative Mg binding site [ion binding]; other site
451516006747	formimidoylglutamase; Provisional; Region: PRK13775
451516006748	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
451516006749	putative active site [active]
451516006750	putative metal binding site [ion binding]; other site
451516006751	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
451516006752	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
451516006753	tetramer (dimer of dimers) interface [polypeptide binding]; other site
451516006754	active site
451516006755	dimer interface [polypeptide binding]; other site
451516006756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
451516006757	MOSC domain; Region: MOSC; pfam03473
451516006758	3-alpha domain; Region: 3-alpha; pfam03475
451516006759	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
451516006760	active site
451516006761	catalytic residues [active]
451516006762	Uncharacterized conserved protein [Function unknown]; Region: COG1742
451516006763	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
451516006764	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
451516006765	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516006766	Walker A/P-loop; other site
451516006767	ATP binding site [chemical binding]; other site
451516006768	Q-loop/lid; other site
451516006769	ABC transporter signature motif; other site
451516006770	Walker B; other site
451516006771	D-loop; other site
451516006772	H-loop/switch region; other site
451516006773	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
451516006774	Predicted membrane protein [Function unknown]; Region: COG3152
451516006775	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
451516006776	active site
451516006777	DNA binding site [nucleotide binding]
451516006778	Sodium/glutamate symporter; Region: Glt_symporter; pfam03616
451516006779	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
451516006780	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
451516006781	homotetramer interface [polypeptide binding]; other site
451516006782	FMN binding site [chemical binding]; other site
451516006783	homodimer contacts [polypeptide binding]; other site
451516006784	putative active site [active]
451516006785	putative substrate binding site [chemical binding]; other site
451516006786	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
451516006787	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
451516006788	oligomer interface [polypeptide binding]; other site
451516006789	metal binding site [ion binding]; metal-binding site
451516006790	metal binding site [ion binding]; metal-binding site
451516006791	putative Cl binding site [ion binding]; other site
451516006792	aspartate ring; other site
451516006793	basic sphincter; other site
451516006794	hydrophobic gate; other site
451516006795	periplasmic entrance; other site
451516006796	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
451516006797	active site
451516006798	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
451516006799	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
451516006800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006801	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
451516006802	putative substrate translocation pore; other site
451516006803	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006804	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
451516006805	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
451516006806	HlyD family secretion protein; Region: HlyD_3; pfam13437
451516006807	lipoyl-biotinyl attachment site [posttranslational modification]; other site
451516006808	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
451516006809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006810	putative substrate translocation pore; other site
451516006811	Predicted membrane protein [Function unknown]; Region: COG4640
451516006812	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
451516006813	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
451516006814	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
451516006815	putative Zn2+ binding site [ion binding]; other site
451516006816	putative DNA binding site [nucleotide binding]; other site
451516006817	Uncharacterized conserved protein [Function unknown]; Region: COG1434
451516006818	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
451516006819	putative active site [active]
451516006820	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
451516006821	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
451516006822	Walker A/P-loop; other site
451516006823	ATP binding site [chemical binding]; other site
451516006824	Q-loop/lid; other site
451516006825	ABC transporter signature motif; other site
451516006826	Walker B; other site
451516006827	D-loop; other site
451516006828	H-loop/switch region; other site
451516006829	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
451516006830	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
451516006831	FtsX-like permease family; Region: FtsX; pfam02687
451516006832	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
451516006833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516006834	active site
451516006835	phosphorylation site [posttranslational modification]
451516006836	intermolecular recognition site; other site
451516006837	dimerization interface [polypeptide binding]; other site
451516006838	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
451516006839	DNA binding site [nucleotide binding]
451516006840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
451516006841	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
451516006842	dimerization interface [polypeptide binding]; other site
451516006843	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
451516006844	dimer interface [polypeptide binding]; other site
451516006845	phosphorylation site [posttranslational modification]
451516006846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516006847	ATP binding site [chemical binding]; other site
451516006848	Mg2+ binding site [ion binding]; other site
451516006849	G-X-G motif; other site
451516006850	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
451516006851	LytTr DNA-binding domain; Region: LytTR; smart00850
451516006852	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
451516006853	Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039
451516006854	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
451516006855	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
451516006856	L-lactate permease; Region: Lactate_perm; cl00701
451516006857	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
451516006858	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516006859	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
451516006860	Coenzyme A binding pocket [chemical binding]; other site
451516006861	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
451516006862	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
451516006863	NAD(P) binding site [chemical binding]; other site
451516006864	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516006865	Coenzyme A binding pocket [chemical binding]; other site
451516006866	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
451516006867	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
451516006868	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516006869	Protein of unknown function (DUF2871); Region: DUF2871; pfam11070
451516006870	Predicted membrane protein [Function unknown]; Region: COG1511
451516006871	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
451516006872	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
451516006873	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
451516006874	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
451516006875	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
451516006876	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
451516006877	Cl binding site [ion binding]; other site
451516006878	oligomer interface [polypeptide binding]; other site
451516006879	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
451516006880	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
451516006881	active site turn [active]
451516006882	phosphorylation site [posttranslational modification]
451516006883	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
451516006884	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
451516006885	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
451516006886	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
451516006887	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
451516006888	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
451516006889	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
451516006890	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
451516006891	MarR family; Region: MarR_2; pfam12802
451516006892	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
451516006893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006894	putative substrate translocation pore; other site
451516006895	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
451516006896	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
451516006897	DNA binding residues [nucleotide binding]
451516006898	dimer interface [polypeptide binding]; other site
451516006899	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
451516006900	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
451516006901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516006902	active site
451516006903	phosphorylation site [posttranslational modification]
451516006904	intermolecular recognition site; other site
451516006905	dimerization interface [polypeptide binding]; other site
451516006906	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
451516006907	DNA binding residues [nucleotide binding]
451516006908	dimerization interface [polypeptide binding]; other site
451516006909	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
451516006910	Histidine kinase; Region: HisKA_3; pfam07730
451516006911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516006912	ATP binding site [chemical binding]; other site
451516006913	Mg2+ binding site [ion binding]; other site
451516006914	G-X-G motif; other site
451516006915	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
451516006916	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
451516006917	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
451516006918	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
451516006919	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
451516006920	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
451516006921	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
451516006922	[4Fe-4S] binding site [ion binding]; other site
451516006923	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
451516006924	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
451516006925	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
451516006926	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
451516006927	molybdopterin cofactor binding site; other site
451516006928	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
451516006929	active site
451516006930	SAM binding site [chemical binding]; other site
451516006931	homodimer interface [polypeptide binding]; other site
451516006932	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
451516006933	[2Fe-2S] cluster binding site [ion binding]; other site
451516006934	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
451516006935	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
451516006936	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
451516006937	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
451516006938	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
451516006939	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
451516006940	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
451516006941	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
451516006942	putative active site [active]
451516006943	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
451516006944	active site
451516006945	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
451516006946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516006947	Coenzyme A binding pocket [chemical binding]; other site
451516006948	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
451516006949	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
451516006950	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
451516006951	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
451516006952	intersubunit interface [polypeptide binding]; other site
451516006953	YodA lipocalin-like domain; Region: YodA; pfam09223
451516006954	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
451516006955	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
451516006956	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
451516006957	Thioredoxin; Region: Thioredoxin_4; cl17273
451516006958	FemAB family; Region: FemAB; pfam02388
451516006959	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
451516006960	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
451516006961	Walker A/P-loop; other site
451516006962	ATP binding site [chemical binding]; other site
451516006963	Q-loop/lid; other site
451516006964	ABC transporter signature motif; other site
451516006965	Walker B; other site
451516006966	D-loop; other site
451516006967	H-loop/switch region; other site
451516006968	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
451516006969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516006970	dimer interface [polypeptide binding]; other site
451516006971	conserved gate region; other site
451516006972	putative PBP binding loops; other site
451516006973	ABC-ATPase subunit interface; other site
451516006974	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
451516006975	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
451516006976	substrate binding pocket [chemical binding]; other site
451516006977	membrane-bound complex binding site; other site
451516006978	hinge residues; other site
451516006979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006980	Major Facilitator Superfamily; Region: MFS_1; pfam07690
451516006981	putative substrate translocation pore; other site
451516006982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516006983	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
451516006984	catalytic core [active]
451516006985	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
451516006986	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
451516006987	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
451516006988	B domain; Region: B; pfam02216
451516006989	B domain; Region: B; pfam02216
451516006990	C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621
451516006991	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
451516006992	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
451516006993	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
451516006994	Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424
451516006995	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
451516006996	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
451516006997	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
451516006998	catalytic residue [active]
451516006999	biotin synthase; Validated; Region: PRK06256
451516007000	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516007001	FeS/SAM binding site; other site
451516007002	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
451516007003	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
451516007004	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
451516007005	inhibitor-cofactor binding pocket; inhibition site
451516007006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516007007	catalytic residue [active]
451516007008	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
451516007009	AAA domain; Region: AAA_26; pfam13500
451516007010	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
451516007011	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
451516007012	Walker A/P-loop; other site
451516007013	ATP binding site [chemical binding]; other site
451516007014	Q-loop/lid; other site
451516007015	ABC transporter signature motif; other site
451516007016	Walker B; other site
451516007017	D-loop; other site
451516007018	H-loop/switch region; other site
451516007019	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
451516007020	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
451516007021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516007022	Walker A/P-loop; other site
451516007023	ATP binding site [chemical binding]; other site
451516007024	Q-loop/lid; other site
451516007025	ABC transporter signature motif; other site
451516007026	Walker B; other site
451516007027	D-loop; other site
451516007028	H-loop/switch region; other site
451516007029	Predicted membrane protein [Function unknown]; Region: COG2246
451516007030	GtrA-like protein; Region: GtrA; pfam04138
451516007031	glycerate kinase; Region: TIGR00045
451516007032	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
451516007033	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
451516007034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516007035	putative substrate translocation pore; other site
451516007036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
451516007037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990
451516007038	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
451516007039	putative phosphoesterase; Region: acc_ester; TIGR03729
451516007040	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
451516007041	Spore germination protein; Region: Spore_permease; cl17796
451516007042	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
451516007043	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
451516007044	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
451516007045	Beta-lactamase; Region: Beta-lactamase; pfam00144
451516007046	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
451516007047	extended (e) SDRs; Region: SDR_e; cd08946
451516007048	NAD(P) binding site [chemical binding]; other site
451516007049	active site
451516007050	substrate binding site [chemical binding]; other site
451516007051	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
451516007052	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
451516007053	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
451516007054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516007055	putative substrate translocation pore; other site
451516007056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516007057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516007058	dimer interface [polypeptide binding]; other site
451516007059	conserved gate region; other site
451516007060	ABC-ATPase subunit interface; other site
451516007061	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
451516007062	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
451516007063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516007064	dimer interface [polypeptide binding]; other site
451516007065	conserved gate region; other site
451516007066	putative PBP binding loops; other site
451516007067	ABC-ATPase subunit interface; other site
451516007068	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
451516007069	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
451516007070	Walker A/P-loop; other site
451516007071	ATP binding site [chemical binding]; other site
451516007072	Q-loop/lid; other site
451516007073	ABC transporter signature motif; other site
451516007074	Walker B; other site
451516007075	D-loop; other site
451516007076	H-loop/switch region; other site
451516007077	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
451516007078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
451516007079	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
451516007080	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
451516007081	amino acid transporter; Region: 2A0306; TIGR00909
451516007082	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
451516007083	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
451516007084	substrate binding pocket [chemical binding]; other site
451516007085	catalytic triad [active]
451516007086	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
451516007087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516007088	putative substrate translocation pore; other site
451516007089	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
451516007090	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
451516007091	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
451516007092	Walker A/P-loop; other site
451516007093	ATP binding site [chemical binding]; other site
451516007094	Q-loop/lid; other site
451516007095	ABC transporter signature motif; other site
451516007096	Walker B; other site
451516007097	D-loop; other site
451516007098	H-loop/switch region; other site
451516007099	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
451516007100	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
451516007101	oligomer interface [polypeptide binding]; other site
451516007102	active site
451516007103	metal binding site [ion binding]; metal-binding site
451516007104	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115
451516007105	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
451516007106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
451516007107	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
451516007108	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
451516007109	active site
451516007110	FMN binding site [chemical binding]; other site
451516007111	substrate binding site [chemical binding]; other site
451516007112	3Fe-4S cluster binding site [ion binding]; other site
451516007113	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516007114	Major Facilitator Superfamily; Region: MFS_1; pfam07690
451516007115	putative substrate translocation pore; other site
451516007116	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
451516007117	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516007118	Walker A/P-loop; other site
451516007119	ATP binding site [chemical binding]; other site
451516007120	Q-loop/lid; other site
451516007121	ABC transporter signature motif; other site
451516007122	Walker B; other site
451516007123	D-loop; other site
451516007124	H-loop/switch region; other site
451516007125	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
451516007126	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
451516007127	Walker A/P-loop; other site
451516007128	ATP binding site [chemical binding]; other site
451516007129	Q-loop/lid; other site
451516007130	ABC transporter signature motif; other site
451516007131	Walker B; other site
451516007132	D-loop; other site
451516007133	H-loop/switch region; other site
451516007134	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
451516007135	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
451516007136	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
451516007137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516007138	dimer interface [polypeptide binding]; other site
451516007139	conserved gate region; other site
451516007140	putative PBP binding loops; other site
451516007141	ABC-ATPase subunit interface; other site
451516007142	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
451516007143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
451516007144	dimer interface [polypeptide binding]; other site
451516007145	conserved gate region; other site
451516007146	putative PBP binding loops; other site
451516007147	ABC-ATPase subunit interface; other site
451516007148	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
451516007149	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
451516007150	substrate binding site [chemical binding]; other site
451516007151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
451516007152	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
451516007153	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
451516007154	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
451516007155	AbgT putative transporter family; Region: ABG_transport; pfam03806
451516007156	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
451516007157	Uncharacterized conserved protein [Function unknown]; Region: COG2128
451516007158	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
451516007159	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
451516007160	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
451516007161	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
451516007162	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
451516007163	classical (c) SDRs; Region: SDR_c; cd05233
451516007164	NAD(P) binding site [chemical binding]; other site
451516007165	active site
451516007166	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516007167	Protein of unknown function, DUF576; Region: DUF576; pfam04507
451516007168	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
451516007169	PLD-like domain; Region: PLDc_2; pfam13091
451516007170	putative homodimer interface [polypeptide binding]; other site
451516007171	putative active site [active]
451516007172	catalytic site [active]
451516007173	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
451516007174	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
451516007175	ATP binding site [chemical binding]; other site
451516007176	putative Mg++ binding site [ion binding]; other site
451516007177	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
451516007178	nucleotide binding region [chemical binding]; other site
451516007179	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
451516007180	ATP-binding site [chemical binding]; other site
451516007181	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
451516007182	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
451516007183	active site
451516007184	8-oxo-dGMP binding site [chemical binding]; other site
451516007185	nudix motif; other site
451516007186	metal binding site [ion binding]; metal-binding site
451516007187	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
451516007188	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
451516007189	active site
451516007190	substrate binding site [chemical binding]; other site
451516007191	metal binding site [ion binding]; metal-binding site
451516007192	H+ Antiporter protein; Region: 2A0121; TIGR00900
451516007193	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516007194	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
451516007195	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516007196	Transcriptional regulators [Transcription]; Region: MarR; COG1846
451516007197	staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889
451516007198	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
451516007199	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
451516007200	active site
451516007201	tetramer interface; other site
451516007202	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516007203	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
451516007204	Fibronectin binding repeat; Region: Fn_bind; pfam02986
451516007205	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
451516007206	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516007207	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
451516007208	Fibronectin binding repeat; Region: Fn_bind; pfam02986
451516007209	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
451516007210	GntP family permease; Region: GntP_permease; pfam02447
451516007211	fructuronate transporter; Provisional; Region: PRK10034; cl15264
451516007212	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
451516007213	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
451516007214	N- and C-terminal domain interface [polypeptide binding]; other site
451516007215	active site
451516007216	catalytic site [active]
451516007217	metal binding site [ion binding]; metal-binding site
451516007218	carbohydrate binding site [chemical binding]; other site
451516007219	ATP binding site [chemical binding]; other site
451516007220	Transcriptional regulators [Transcription]; Region: GntR; COG1802
451516007221	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
451516007222	DNA-binding site [nucleotide binding]; DNA binding site
451516007223	FCD domain; Region: FCD; pfam07729
451516007224	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
451516007225	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
451516007226	DNA binding residues [nucleotide binding]
451516007227	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
451516007228	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
451516007229	synthetase active site [active]
451516007230	NTP binding site [chemical binding]; other site
451516007231	metal binding site [ion binding]; metal-binding site
451516007232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
451516007233	Predicted membrane protein [Function unknown]; Region: COG1289
451516007234	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
451516007235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516007236	D-galactonate transporter; Region: 2A0114; TIGR00893
451516007237	putative substrate translocation pore; other site
451516007238	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
451516007239	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
451516007240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
451516007241	Major Facilitator Superfamily; Region: MFS_1; pfam07690
451516007242	putative substrate translocation pore; other site
451516007243	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
451516007244	MarR family; Region: MarR; pfam01047
451516007245	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
451516007246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516007247	Walker A/P-loop; other site
451516007248	ATP binding site [chemical binding]; other site
451516007249	Q-loop/lid; other site
451516007250	ABC transporter signature motif; other site
451516007251	Walker B; other site
451516007252	D-loop; other site
451516007253	H-loop/switch region; other site
451516007254	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
451516007255	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
451516007256	Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855
451516007257	Uncharacterized membrane protein [Function unknown]; Region: COG3949
451516007258	Predicted esterase [General function prediction only]; Region: COG0400
451516007259	putative hydrolase; Provisional; Region: PRK11460
451516007260	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
451516007261	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
451516007262	Zn binding site [ion binding]; other site
451516007263	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
451516007264	Zn binding site [ion binding]; other site
451516007265	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
451516007266	MarR family; Region: MarR; pfam01047
451516007267	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
451516007268	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
451516007269	putative metal binding site [ion binding]; other site
451516007270	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
451516007271	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
451516007272	dimer interface [polypeptide binding]; other site
451516007273	FMN binding site [chemical binding]; other site
451516007274	D-lactate dehydrogenase; Provisional; Region: PRK12480
451516007275	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
451516007276	homodimer interface [polypeptide binding]; other site
451516007277	ligand binding site [chemical binding]; other site
451516007278	NAD binding site [chemical binding]; other site
451516007279	catalytic site [active]
451516007280	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
451516007281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
451516007282	active site
451516007283	motif I; other site
451516007284	motif II; other site
451516007285	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
451516007286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
451516007287	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
451516007288	Walker A/P-loop; other site
451516007289	ATP binding site [chemical binding]; other site
451516007290	Q-loop/lid; other site
451516007291	ABC transporter signature motif; other site
451516007292	Walker B; other site
451516007293	D-loop; other site
451516007294	H-loop/switch region; other site
451516007295	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
451516007296	active site
451516007297	catalytic site [active]
451516007298	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
451516007299	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516007300	Coenzyme A binding pocket [chemical binding]; other site
451516007301	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
451516007302	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
451516007303	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
451516007304	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
451516007305	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
451516007306	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
451516007307	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
451516007308	EamA-like transporter family; Region: EamA; pfam00892
451516007309	EamA-like transporter family; Region: EamA; pfam00892
451516007310	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
451516007311	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
451516007312	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
451516007313	catalytic residues [active]
451516007314	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
451516007315	active site
451516007316	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
451516007317	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
451516007318	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
451516007319	active site turn [active]
451516007320	phosphorylation site [posttranslational modification]
451516007321	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
451516007322	HPr interaction site; other site
451516007323	glycerol kinase (GK) interaction site [polypeptide binding]; other site
451516007324	active site
451516007325	phosphorylation site [posttranslational modification]
451516007326	pyruvate oxidase; Provisional; Region: PRK08611
451516007327	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
451516007328	PYR/PP interface [polypeptide binding]; other site
451516007329	tetramer interface [polypeptide binding]; other site
451516007330	dimer interface [polypeptide binding]; other site
451516007331	TPP binding site [chemical binding]; other site
451516007332	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
451516007333	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
451516007334	TPP-binding site [chemical binding]; other site
451516007335	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
451516007336	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
451516007337	Transcriptional regulator [Transcription]; Region: LysR; COG0583
451516007338	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
451516007339	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
451516007340	putative dimerization interface [polypeptide binding]; other site
451516007341	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
451516007342	Surface antigen [General function prediction only]; Region: COG3942
451516007343	CHAP domain; Region: CHAP; pfam05257
451516007344	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
451516007345	homodimer interface [polypeptide binding]; other site
451516007346	catalytic residues [active]
451516007347	NAD binding site [chemical binding]; other site
451516007348	substrate binding pocket [chemical binding]; other site
451516007349	flexible flap; other site
451516007350	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
451516007351	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
451516007352	dimer interface [polypeptide binding]; other site
451516007353	active site
451516007354	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
451516007355	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
451516007356	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
451516007357	DNA binding site [nucleotide binding]
451516007358	active site
451516007359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516007360	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
451516007361	Walker A motif; other site
451516007362	ATP binding site [chemical binding]; other site
451516007363	Walker B motif; other site
451516007364	arginine finger; other site
451516007365	UvrB/uvrC motif; Region: UVR; pfam02151
451516007366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
451516007367	Walker A motif; other site
451516007368	ATP binding site [chemical binding]; other site
451516007369	Walker B motif; other site
451516007370	arginine finger; other site
451516007371	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
451516007372	Virus attachment protein p12 family; Region: P12; pfam12669
451516007373	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
451516007374	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
451516007375	G1 box; other site
451516007376	GTP/Mg2+ binding site [chemical binding]; other site
451516007377	Switch I region; other site
451516007378	G2 box; other site
451516007379	G3 box; other site
451516007380	Switch II region; other site
451516007381	G4 box; other site
451516007382	G5 box; other site
451516007383	Nucleoside recognition; Region: Gate; pfam07670
451516007384	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
451516007385	Nucleoside recognition; Region: Gate; pfam07670
451516007386	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
451516007387	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
451516007388	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
451516007389	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
451516007390	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
451516007391	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
451516007392	Glutamate binding site [chemical binding]; other site
451516007393	homodimer interface [polypeptide binding]; other site
451516007394	NAD binding site [chemical binding]; other site
451516007395	catalytic residues [active]
451516007396	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
451516007397	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
451516007398	active site
451516007399	substrate binding site [chemical binding]; other site
451516007400	trimer interface [polypeptide binding]; other site
451516007401	CoA binding site [chemical binding]; other site
451516007402	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
451516007403	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
451516007404	metal-binding site [ion binding]
451516007405	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
451516007406	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
451516007407	metal-binding site [ion binding]
451516007408	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
451516007409	Soluble P-type ATPase [General function prediction only]; Region: COG4087
451516007410	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
451516007411	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
451516007412	metal-binding site [ion binding]
451516007413	D-lactate dehydrogenase; Validated; Region: PRK08605
451516007414	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
451516007415	homodimer interface [polypeptide binding]; other site
451516007416	ligand binding site [chemical binding]; other site
451516007417	NAD binding site [chemical binding]; other site
451516007418	catalytic site [active]
451516007419	transaminase; Reviewed; Region: PRK08068
451516007420	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
451516007421	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516007422	homodimer interface [polypeptide binding]; other site
451516007423	catalytic residue [active]
451516007424	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
451516007425	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
451516007426	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
451516007427	active site lid residues [active]
451516007428	substrate binding pocket [chemical binding]; other site
451516007429	catalytic residues [active]
451516007430	substrate-Mg2+ binding site; other site
451516007431	aspartate-rich region 1; other site
451516007432	aspartate-rich region 2; other site
451516007433	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
451516007434	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
451516007435	active site
451516007436	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
451516007437	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
451516007438	Surface antigen [General function prediction only]; Region: COG3942
451516007439	CHAP domain; Region: CHAP; pfam05257
451516007440	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
451516007441	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
451516007442	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
451516007443	catalytic triad [active]
451516007444	catalytic triad [active]
451516007445	oxyanion hole [active]
451516007446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516007447	Coenzyme A binding pocket [chemical binding]; other site
451516007448	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
451516007449	N-acetyl-D-glucosamine binding site [chemical binding]; other site
451516007450	catalytic residue [active]
451516007451	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
451516007452	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
451516007453	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
451516007454	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
451516007455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
451516007456	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
451516007457	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
451516007458	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
451516007459	NmrA-like family; Region: NmrA; pfam05368
451516007460	NADP binding site [chemical binding]; other site
451516007461	active site
451516007462	regulatory binding site [polypeptide binding]; other site
451516007463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367
451516007464	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
451516007465	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
451516007466	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
451516007467	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
451516007468	NAD(P) binding site [chemical binding]; other site
451516007469	active site
451516007470	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
451516007471	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
451516007472	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
451516007473	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
451516007474	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
451516007475	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
451516007476	Nucleoside recognition; Region: Gate; pfam07670
451516007477	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
451516007478	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
451516007479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495
451516007480	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
451516007481	Phosphotransferase enzyme family; Region: APH; pfam01636
451516007482	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
451516007483	active site
451516007484	ATP binding site [chemical binding]; other site
451516007485	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
451516007486	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
451516007487	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
451516007488	quinone interaction residues [chemical binding]; other site
451516007489	active site
451516007490	catalytic residues [active]
451516007491	FMN binding site [chemical binding]; other site
451516007492	substrate binding site [chemical binding]; other site
451516007493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
451516007494	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
451516007495	dimer interface [polypeptide binding]; other site
451516007496	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
451516007497	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
451516007498	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
451516007499	Predicted acyl esterases [General function prediction only]; Region: COG2936
451516007500	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
451516007501	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
451516007502	tetramerization interface [polypeptide binding]; other site
451516007503	active site
451516007504	pantoate--beta-alanine ligase; Region: panC; TIGR00018
451516007505	Pantoate-beta-alanine ligase; Region: PanC; cd00560
451516007506	active site
451516007507	ATP-binding site [chemical binding]; other site
451516007508	pantoate-binding site; other site
451516007509	HXXH motif; other site
451516007510	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
451516007511	oligomerization interface [polypeptide binding]; other site
451516007512	active site
451516007513	metal binding site [ion binding]; metal-binding site
451516007514	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
451516007515	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
451516007516	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
451516007517	amino acid transporter; Region: 2A0306; TIGR00909
451516007518	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
451516007519	4-aminobutyrate aminotransferase; Provisional; Region: PRK08593
451516007520	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
451516007521	inhibitor-cofactor binding pocket; inhibition site
451516007522	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516007523	catalytic residue [active]
451516007524	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
451516007525	catalytic residue [active]
451516007526	malate:quinone oxidoreductase; Reviewed; Region: PRK13339
451516007527	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
451516007528	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
451516007529	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
451516007530	acyl-activating enzyme (AAE) consensus motif; other site
451516007531	AMP binding site [chemical binding]; other site
451516007532	active site
451516007533	CoA binding site [chemical binding]; other site
451516007534	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
451516007535	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
451516007536	choline dehydrogenase; Validated; Region: PRK02106
451516007537	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
451516007538	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
451516007539	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
451516007540	tetramerization interface [polypeptide binding]; other site
451516007541	NAD(P) binding site [chemical binding]; other site
451516007542	catalytic residues [active]
451516007543	Predicted transcriptional regulators [Transcription]; Region: COG1510
451516007544	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
451516007545	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
451516007546	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
451516007547	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
451516007548	FeS/SAM binding site; other site
451516007549	anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487
451516007550	Class III ribonucleotide reductase; Region: RNR_III; cd01675
451516007551	effector binding site; other site
451516007552	active site
451516007553	Zn binding site [ion binding]; other site
451516007554	glycine loop; other site
451516007555	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
451516007556	Citrate transporter; Region: CitMHS; pfam03600
451516007557	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
451516007558	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
451516007559	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
451516007560	Flavodoxin; Region: Flavodoxin_1; pfam00258
451516007561	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
451516007562	FAD binding pocket [chemical binding]; other site
451516007563	FAD binding motif [chemical binding]; other site
451516007564	catalytic residues [active]
451516007565	NAD binding pocket [chemical binding]; other site
451516007566	phosphate binding motif [ion binding]; other site
451516007567	beta-alpha-beta structure motif; other site
451516007568	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
451516007569	catalytic residues [active]
451516007570	dimer interface [polypeptide binding]; other site
451516007571	FtsX-like permease family; Region: FtsX; pfam02687
451516007572	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
451516007573	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
451516007574	Walker A/P-loop; other site
451516007575	ATP binding site [chemical binding]; other site
451516007576	Q-loop/lid; other site
451516007577	ABC transporter signature motif; other site
451516007578	Walker B; other site
451516007579	D-loop; other site
451516007580	H-loop/switch region; other site
451516007581	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
451516007582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
451516007583	ATP binding site [chemical binding]; other site
451516007584	Mg2+ binding site [ion binding]; other site
451516007585	G-X-G motif; other site
451516007586	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
451516007587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
451516007588	active site
451516007589	phosphorylation site [posttranslational modification]
451516007590	intermolecular recognition site; other site
451516007591	dimerization interface [polypeptide binding]; other site
451516007592	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
451516007593	DNA binding site [nucleotide binding]
451516007594	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
451516007595	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
451516007596	dimer interface [polypeptide binding]; other site
451516007597	active site
451516007598	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
451516007599	Protein of unknown function (DUF2648); Region: DUF2648; pfam10855
451516007600	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
451516007601	MarR family; Region: MarR_2; pfam12802
451516007602	Predicted esterase [General function prediction only]; Region: COG0627
451516007603	S-formylglutathione hydrolase; Region: PLN02442
451516007604	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
451516007605	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
451516007606	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
451516007607	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
451516007608	ligand binding site [chemical binding]; other site
451516007609	flexible hinge region; other site
451516007610	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
451516007611	carbamate kinase; Reviewed; Region: PRK12686
451516007612	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
451516007613	putative substrate binding site [chemical binding]; other site
451516007614	nucleotide binding site [chemical binding]; other site
451516007615	nucleotide binding site [chemical binding]; other site
451516007616	homodimer interface [polypeptide binding]; other site
451516007617	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
451516007618	ornithine carbamoyltransferase; Validated; Region: PRK02102
451516007619	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
451516007620	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
451516007621	arginine deiminase; Provisional; Region: PRK01388
451516007622	Arginine repressor [Transcription]; Region: ArgR; COG1438
451516007623	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
451516007624	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
451516007625	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
451516007626	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
451516007627	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
451516007628	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
451516007629	active site
451516007630	Zn binding site [ion binding]; other site
451516007631	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
451516007632	HTH domain; Region: HTH_11; pfam08279
451516007633	PRD domain; Region: PRD; pfam00874
451516007634	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
451516007635	active site
451516007636	P-loop; other site
451516007637	phosphorylation site [posttranslational modification]
451516007638	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
451516007639	active site
451516007640	phosphorylation site [posttranslational modification]
451516007641	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
451516007642	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
451516007643	active site
451516007644	P-loop; other site
451516007645	phosphorylation site [posttranslational modification]
451516007646	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
451516007647	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
451516007648	active site
451516007649	phosphorylation site [posttranslational modification]
451516007650	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
451516007651	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
451516007652	Predicted membrane protein [Function unknown]; Region: COG1511
451516007653	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
451516007654	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
451516007655	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
451516007656	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
451516007657	CHAP domain; Region: CHAP; pfam05257
451516007658	Isochorismatase family; Region: Isochorismatase; pfam00857
451516007659	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
451516007660	catalytic triad [active]
451516007661	conserved cis-peptide bond; other site
451516007662	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
451516007663	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
451516007664	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
451516007665	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
451516007666	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
451516007667	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
451516007668	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
451516007669	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
451516007670	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
451516007671	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
451516007672	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
451516007673	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
451516007674	SecY translocase; Region: SecY; pfam00344
451516007675	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
451516007676	legume lectins; Region: lectin_L-type; cd01951
451516007677	homotetramer interaction site [polypeptide binding]; other site
451516007678	carbohydrate binding site [chemical binding]; other site
451516007679	metal binding site [ion binding]; metal-binding site
451516007680	Putative Ig domain; Region: He_PIG; pfam05345
451516007681	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
451516007682	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
451516007683	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
451516007684	methionine sulfoxide reductase A; Provisional; Region: PRK05528
451516007685	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
451516007686	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
451516007687	Coenzyme A binding pocket [chemical binding]; other site
451516007688	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
451516007689	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
451516007690	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
451516007691	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
451516007692	Chain length determinant protein; Region: Wzz; cl15801
451516007693	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
451516007694	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
451516007695	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
451516007696	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
451516007697	DXD motif; other site
451516007698	intracellular adhesion protein D; Region: PIA_icaD; TIGR03932
451516007699	intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933
451516007700	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
451516007701	Acyltransferase family; Region: Acyl_transf_3; pfam01757
451516007702	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
451516007703	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
451516007704	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
451516007705	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
451516007706	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
451516007707	metal binding site [ion binding]; metal-binding site
451516007708	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
451516007709	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
451516007710	substrate binding site [chemical binding]; other site
451516007711	glutamase interaction surface [polypeptide binding]; other site
451516007712	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
451516007713	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
451516007714	catalytic residues [active]
451516007715	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
451516007716	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
451516007717	putative active site [active]
451516007718	oxyanion strand; other site
451516007719	catalytic triad [active]
451516007720	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
451516007721	putative active site pocket [active]
451516007722	4-fold oligomerization interface [polypeptide binding]; other site
451516007723	metal binding residues [ion binding]; metal-binding site
451516007724	3-fold/trimer interface [polypeptide binding]; other site
451516007725	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
451516007726	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
451516007727	pyridoxal 5'-phosphate binding site [chemical binding]; other site
451516007728	homodimer interface [polypeptide binding]; other site
451516007729	catalytic residue [active]
451516007730	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
451516007731	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
451516007732	NAD binding site [chemical binding]; other site
451516007733	dimerization interface [polypeptide binding]; other site
451516007734	product binding site; other site
451516007735	substrate binding site [chemical binding]; other site
451516007736	zinc binding site [ion binding]; other site
451516007737	catalytic residues [active]
451516007738	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584
451516007739	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
451516007740	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294
451516007741	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
451516007742	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
451516007743	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
451516007744	putative active site [active]
451516007745	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
451516007746	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
451516007747	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
451516007748	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
451516007749	Walker A/P-loop; other site
451516007750	ATP binding site [chemical binding]; other site
451516007751	Q-loop/lid; other site
451516007752	ABC transporter signature motif; other site
451516007753	Walker B; other site
451516007754	D-loop; other site
451516007755	H-loop/switch region; other site
451516007756	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
451516007757	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
451516007758	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
451516007759	Walker A/P-loop; other site
451516007760	ATP binding site [chemical binding]; other site
451516007761	Q-loop/lid; other site
451516007762	ABC transporter signature motif; other site
451516007763	Walker B; other site
451516007764	D-loop; other site
451516007765	H-loop/switch region; other site
451516007766	hypothetical protein; Provisional; Region: PRK13661
451516007767	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
451516007768	Uncharacterized conserved protein [Function unknown]; Region: COG1912
451516007769	Uncharacterized conserved protein [Function unknown]; Region: COG2353
451516007770	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
451516007771	Strictosidine synthase; Region: Str_synth; pfam03088
451516007772	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
451516007773	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
451516007774	active site residue [active]
451516007775	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
451516007776	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
451516007777	putative substrate binding pocket [chemical binding]; other site
451516007778	AC domain interface; other site
451516007779	catalytic triad [active]
451516007780	AB domain interface; other site
451516007781	interchain disulfide; other site
451516007782	hypothetical protein; Validated; Region: PRK07668
451516007783	Predicted transcriptional regulators [Transcription]; Region: COG1695
451516007784	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
451516007785	DinB superfamily; Region: DinB_2; pfam12867
451516007786	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
451516007787	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
451516007788	transmembrane helices; other site
451516007789	Predicted permeases [General function prediction only]; Region: RarD; COG2962
451516007790	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
451516007791	hypothetical protein; Provisional; Region: PRK07758
451516007792	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
451516007793	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
451516007794	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
451516007795	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
451516007796	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
451516007797	Walker A/P-loop; other site
451516007798	ATP binding site [chemical binding]; other site
451516007799	Q-loop/lid; other site
451516007800	ABC transporter signature motif; other site
451516007801	Walker B; other site
451516007802	D-loop; other site
451516007803	H-loop/switch region; other site
451516007804	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
451516007805	FtsX-like permease family; Region: FtsX; pfam02687
451516007806	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
451516007807	Integrase core domain; Region: rve; pfam00665
451516007808	Integrase core domain; Region: rve_3; cl15866
451516007809	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
451516007810	Integrase core domain; Region: rve_3; cl15866
451516007811	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
451516007812	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
451516007813	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
451516007814	ParB-like nuclease domain; Region: ParBc; pfam02195
451516007815	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
451516007816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
451516007817	S-adenosylmethionine binding site [chemical binding]; other site
451516007818	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
451516007819	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
451516007820	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
451516007821	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
451516007822	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
451516007823	trmE is a tRNA modification GTPase; Region: trmE; cd04164
451516007824	G1 box; other site
451516007825	GTP/Mg2+ binding site [chemical binding]; other site
451516007826	Switch I region; other site
451516007827	G2 box; other site
451516007828	Switch II region; other site
451516007829	G3 box; other site
451516007830	G4 box; other site
451516007831	G5 box; other site
451516007832	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
451516007833	ribonuclease P; Reviewed; Region: rnpA; PRK00499
451516007834	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
451516007835	Replication protein; Region: Rep_1; pfam01446