-- dump date 20140620_074609 -- class Genbank::CDS -- table cds_note -- id note YP_498609.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_498610.1 binds the polymerase to DNA and acts as a sliding clamp YP_498611.1 conserved hypothetical protein YP_498612.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_498613.1 DNA gyrase, B subunit YP_498614.1 DNA gyrase, A subunit YP_498615.1 conserved hypothetical protein YP_498616.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_498617.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_498618.1 conserved hypothetical protein YP_498619.1 conserved hypothetical protein YP_498620.1 conserved hypothetical protein YP_498621.1 conserved hypothetical protein YP_498622.1 conserved hypothetical protein YP_498623.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_498625.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_498626.1 two-component response regulator, putative YP_498627.1 sensory box histidine kinase VicK, putative YP_498628.1 conserved hypothetical protein YP_498629.1 conserved hypothetical protein YP_498630.1 conserved hypothetical protein YP_498631.1 conserved hypothetical protein YP_498632.1 conserved hypothetical protein YP_498633.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_498635.1 conserved hypothetical protein YP_498636.1 conserved hypothetical protein YP_498637.1 conserved hypothetical protein YP_498638.1 conserved hypothetical protein YP_498639.1 conserved hypothetical protein YP_498640.1 conserved hypothetical protein YP_498641.1 conserved hypothetical protein YP_498642.1 conserved hypothetical protein YP_498643.1 conserved hypothetical protein YP_498644.1 conserved hypothetical protein YP_498645.1 conserved hypothetical protein YP_498646.1 conserved hypothetical protein YP_498647.1 conserved hypothetical protein YP_498648.1 conserved hypothetical protein YP_498649.1 conserved hypothetical protein YP_498650.1 conserved hypothetical protein YP_498651.1 conserved hypothetical protein YP_498652.1 conserved hypothetical protein YP_498653.1 conserved hypothetical protein YP_498654.1 conserved hypothetical protein YP_498655.1 conserved hypothetical protein YP_498656.1 1-phosphatidylinositol phosphodiesterase precursor, putative YP_498657.1 conserved hypothetical protein YP_498658.1 conserved hypothetical protein YP_498659.1 conserved hypothetical protein YP_498660.1 conserved hypothetical protein YP_498661.1 conserved hypothetical protein YP_498662.1 conserved hypothetical protein YP_498663.1 conserved hypothetical protein YP_498664.1 conserved hypothetical protein YP_498665.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever YP_498666.1 conserved hypothetical protein YP_498667.1 conserved hypothetical protein YP_498668.1 conserved hypothetical protein YP_498671.1 staphylococcal accessory regulator-like protein YP_498672.1 lipoprotein, SirC, putative YP_498673.1 lipoprotein, SirB, putative YP_498674.1 periplasmic binding protein, putative YP_498675.1 conserved hypothetical protein YP_498676.1 ornithine cyclodeaminase, putative YP_498677.1 conserved hypothetical protein YP_498678.1 conserved hypothetical protein YP_498679.1 conserved hypothetical protein YP_498680.1 conserved hypothetical protein YP_498681.1 conserved hypothetical protein YP_498682.1 conserved hypothetical protein YP_498683.1 conserved hypothetical protein YP_498685.1 conserved hypothetical protein YP_498686.1 conserved hypothetical protein YP_498687.1 3-ketoacyl-acyl carrier protein reductase, putative YP_498688.1 conserved hypothetical protein YP_498689.1 conserved hypothetical protein YP_498690.1 conserved hypothetical protein YP_498691.1 conserved hypothetical protein YP_498692.1 conserved hypothetical protein YP_498693.1 conserved hypothetical protein YP_498694.1 superoxide dismutase, putative YP_498695.1 conserved hypothetical protein YP_498696.1 transcriptional regulator, GntR family, putative YP_498698.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_498699.1 conserved hypothetical protein YP_498700.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_498701.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_498702.1 phosphonates ABC transporter, permease protein CC0363, putative YP_498703.1 phosphonates ABC transporter, permease protein CC0363, putative YP_498704.1 amino acid ABC transporter, ATP-binding protein, putative YP_498705.1 phosphonate ABC transporter, substrate-binding protein, putative YP_498706.1 conserved hypothetical protein YP_498707.1 conserved hypothetical protein YP_498708.1 conserved hypothetical protein YP_498709.1 replication initiation protein, putative YP_498713.1 alcohol dehydrogenase, iron-containing, putative YP_498714.1 capsular polysaccharide biosynthesis protein, putative YP_498715.1 capsular polysaccharide synthesis enzyme Cap5B YP_498716.1 capsular polysaccharide synthesis enzyme Cap8C YP_498717.1 capsular polysaccharide biosynthesis protein Cap5D, putative YP_498718.1 capsular polysaccharide biosynthesis protein Cap5E, putative YP_498719.1 capsular polysaccharide synthesis enzyme Cap8F YP_498721.1 capsular polysaccharide synthesis enzyme O-acetyl transferase Cap5H, putative YP_498722.1 capsular polysaccharide biosynthesis protein Cap5I, putative YP_498723.1 capsular polysaccharide biosynthesis protein Cap5J, putative YP_498724.1 capsular polysaccharide biosynthesis protein Cap5K, putative YP_498725.1 cap5L protein/glycosyltransferase, putative YP_498727.1 cap5N protein/UDP-glucose 4-epimerase, putative YP_498730.1 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source YP_498731.1 conserved hypothetical protein YP_498732.1 aldehyde dehydrogenase, putative YP_498733.1 conserved hypothetical protein YP_498734.1 conserved hypothetical protein YP_498735.1 conserved hypothetical protein YP_498736.1 conserved hypothetical protein YP_498737.1 conserved hypothetical protein YP_498738.1 conserved hypothetical protein YP_498739.1 conserved hypothetical protein YP_498740.1 conserved hypothetical protein YP_498741.1 Catalyzes the reversible two-electron oxidation of formate to carbon dioxide. It allows the assimilation of carbon dioxide and provides energy for growth through oxidative phosphorylation coupled to the reduction of oxygen, nitrate, sulphate or fumarate YP_498742.1 conserved hypothetical protein YP_498743.1 conserved hypothetical protein YP_498744.1 conserved hypothetical protein YP_498745.1 conserved hypothetical protein YP_498746.1 acetylglutamate kinase, putative YP_498747.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_498748.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_498749.1 ornithine aminotransferase, putative YP_498751.1 conserved hypothetical protein YP_498752.1 indolepyruvate decarboxylase, putative YP_498753.1 conserved hypothetical protein YP_498754.1 PTS system, glucose-specific component YP_498755.1 conserved hypothetical protein YP_498756.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_498757.1 PTS system component YP_498758.1 conserved hypothetical protein YP_498759.1 conserved hypothetical protein YP_498760.1 type I site-specific deoxyribonuclease, HsdR family, putative YP_498761.1 conserved hypothetical protein YP_498762.1 conserved hypothetical protein YP_498763.1 conserved hypothetical protein YP_498764.1 peptide ABC transporter, ATP-binding protein, putative YP_498765.1 conserved hypothetical protein YP_498766.1 peptide ABC transporter, permease protein, putative YP_498767.1 conserved hypothetical protein YP_498768.1 gamma-glutamyltranspeptidase, putative YP_498769.1 conserved hypothetical protein YP_498770.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_498771.1 M23/M37 peptidase domain protein YP_498772.1 multiple sugar-binding transport ATP-binding protein, putative YP_498773.1 bacterial extracellular solute-binding protein, putative YP_498774.1 maltose ABC transporter, permease protein, putative YP_498775.1 maltose ABC transporter, permease protein YP_498776.1 conserved hypothetical protein YP_498777.1 conserved hypothetical protein YP_498778.1 conserved hypothetical protein YP_498779.1 conserved hypothetical protein YP_498780.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_498781.1 Response regulator receiver domain protein YP_498782.1 conserved hypothetical protein YP_498783.1 lipoprotein, putative YP_498785.1 pyruvate formate-lyase 1 activating enzyme, putative YP_498787.1 conserved hypothetical protein YP_498788.1 conserved hypothetical protein YP_498789.1 coagulase YP_498792.1 acetyl-CoA acetyltransferase, putative YP_498793.1 conserved hypothetical protein YP_498794.1 conserved hypothetical protein YP_498795.1 conserved hypothetical protein YP_498796.1 conserved hypothetical protein YP_498797.1 membrane protein, putative YP_498798.1 conserved hypothetical protein YP_498799.1 conserved hypothetical protein YP_498800.1 conserved hypothetical protein YP_498801.1 Globin domain protein YP_498805.1 PTS system, glucose-specific IIBC component, putative YP_498806.1 conserved hypothetical protein YP_498807.1 conserved hypothetical protein YP_498808.1 conserved hypothetical protein YP_498809.1 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, putative YP_498810.1 PTS system component, putative YP_498811.1 PTS system component YP_498812.1 sorbitol dehydrogenase, putative YP_498813.1 conserved hypothetical protein YP_498814.1 conserved hypothetical protein YP_498815.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_498816.1 alcohol dehydrogenase, zinc-containing YP_498818.1 tagB protein, putative YP_498819.1 teichoic acid biosynthesis protein F, putative YP_498820.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_498821.1 conserved hypothetical protein YP_498822.1 conserved hypothetical protein YP_498823.1 conserved hypothetical protein YP_498824.1 involved in peptidoglycan cross-linking YP_498825.1 two-component sensor histidine kinase, putative YP_498826.1 two-component response regulator, putative YP_498827.1 negatively regulates murein hydrolase activity YP_498828.1 in conjunction with LrgA this protein inhibits the expression or activity of extracellular murein hydrolases YP_498829.1 conserved hypothetical protein YP_498830.1 conserved hypothetical protein YP_498831.1 6-phospho-beta-glucosidase, putative YP_498832.1 conserved hypothetical protein YP_498834.1 ribokinase, putative YP_498835.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_498836.1 conserved hypothetical protein YP_498837.1 conserved hypothetical protein YP_498838.1 NADH dehydrogenase subunit, putative YP_498839.1 conserved hypothetical protein YP_498841.1 drug transporter, putative YP_498842.1 conserved hypothetical protein YP_498843.1 peptidoglycan hydrolase, putative YP_498844.1 conserved hypothetical protein YP_498845.1 conserved hypothetical protein YP_498846.1 conserved hypothetical protein YP_498847.1 conserved hypothetical protein YP_498848.1 conserved hypothetical protein YP_498849.1 conserved hypothetical protein YP_498850.1 conserved hypothetical protein YP_498851.1 conserved hypothetical protein YP_498852.1 conserved hypothetical protein YP_498853.1 conserved hypothetical protein YP_498854.1 conserved hypothetical protein YP_498855.1 conserved hypothetical protein YP_498856.1 conserved hypothetical protein YP_498857.1 conserved hypothetical protein YP_498858.1 conserved hypothetical protein YP_498859.1 conserved hypothetical protein YP_498860.1 conserved hypothetical protein YP_498861.1 conserved hypothetical protein YP_498862.1 conserved hypothetical protein YP_498863.1 conserved hypothetical protein YP_498864.1 conserved hypothetical protein YP_498865.1 conserved hypothetical protein YP_498866.1 conserved hypothetical protein YP_498867.2 conserved hypothetical protein YP_498868.1 conserved hypothetical protein YP_498869.1 conserved hypothetical protein YP_498870.1 conserved hypothetical protein YP_498871.1 conserved hypothetical protein YP_498872.1 conserved hypothetical protein YP_498873.1 conserved hypothetical protein YP_498875.1 5'-nucleotidase, lipoprotein e(P4) family YP_498877.1 conserved hypothetical protein YP_498878.1 ABC transporter, ATP-binding protein, putative YP_498880.1 conserved hypothetical protein YP_498881.1 pfkB family carbohydrate kinase family, putative YP_498882.1 conserved hypothetical protein YP_498883.1 conserved hypothetical protein YP_498884.1 conserved hypothetical protein YP_498885.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_498887.1 conserved hypothetical protein YP_498888.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_498889.1 conserved hypothetical protein YP_498890.1 lipase precursor YP_498891.1 conserved hypothetical protein YP_498892.1 conserved hypothetical protein YP_498894.1 conserved hypothetical protein YP_498895.2 conserved hypothetical protein YP_498896.1 conserved hypothetical protein YP_498897.1 conserved hypothetical protein YP_498898.1 conserved hypothetical protein YP_498899.1 conserved hypothetical protein YP_498900.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_498901.1 conserved hypothetical protein YP_498902.1 conserved hypothetical protein YP_498903.1 conserved hypothetical protein YP_498904.1 conserved hypothetical protein YP_498905.1 conserved hypothetical protein YP_498906.1 conserved hypothetical protein YP_498908.1 conserved hypothetical protein YP_498909.1 conserved hypothetical protein YP_498910.1 NADPH-dependent FMN reductase, putative YP_498911.1 conserved hypothetical protein YP_498912.1 conserved hypothetical protein YP_498913.1 ribosomal-protein-serine acetyltransferase, putative YP_498914.1 conserved hypothetical protein YP_498915.1 conserved hypothetical protein YP_498916.1 conserved hypothetical protein YP_498917.1 conserved hypothetical protein YP_498918.1 mttA/Hcf106 family protein-related protein YP_498919.1 conserved hypothetical protein YP_498920.1 conserved hypothetical protein YP_498921.1 conserved hypothetical protein YP_498922.1 ABC transporter, ATP-binding protein, putative YP_498923.1 conserved hypothetical protein YP_498924.1 conserved hypothetical protein YP_498926.1 acetyl-CoA acetyltransferase, putative YP_498927.1 conserved hypothetical protein YP_498928.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_498929.1 catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions YP_498931.1 conserved hypothetical protein YP_498932.1 chromosome partioning protein, ParB family, putative YP_498933.1 conserved hypothetical protein YP_498934.1 conserved hypothetical protein YP_498935.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_498936.1 conserved hypothetical protein YP_498937.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_498938.1 bacteriophage L54a, single-stranded DNA binding protein YP_498939.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_498940.1 conserved hypothetical protein YP_498942.1 conserved hypothetical protein YP_498943.1 conserved hypothetical protein YP_498944.1 conserved hypothetical protein YP_498945.1 conserved hypothetical protein YP_498946.1 conserved hypothetical protein YP_498947.1 conserved hypothetical protein YP_498948.1 conserved hypothetical protein YP_498950.1 conserved hypothetical protein YP_498951.1 conserved hypothetical protein YP_498952.1 conserved hypothetical protein YP_498953.1 alkyl hydroperoxide reductase, subunit F, putative YP_498954.1 alkyl hydroperoxide reductase YP_498955.1 NAD(P)H-flavin oxidoreductase, putative YP_498956.1 conserved hypothetical protein YP_498957.1 conserved hypothetical protein YP_498958.1 conserved hypothetical protein YP_498959.1 conserved hypothetical protein YP_498960.1 conserved hypothetical protein YP_498961.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_498962.1 xanthine permease, putative YP_498964.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_498965.1 conserved hypothetical protein YP_498966.1 conserved hypothetical protein YP_498967.1 conserved hypothetical protein YP_498969.1 conserved hypothetical protein YP_498970.1 conserved hypothetical protein YP_498971.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498972.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498973.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498974.1 conserved hypothetical protein YP_498975.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498976.1 SSL5, SET3, SET10; bind P-selectin glycoprotein ligand-1 and inhibit P-selectin-mediated neutrophil rolling along the endothelium; these proteins share structural homology to known superantigens but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498978.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498979.1 SSL7, SET1; blocks IgA-FcR interactions and inhibits complement, leading to increased survival of a sensitive bacterium in blood YP_498980.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498981.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498982.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498983.1 conserved hypothetical protein YP_498984.1 type I restriction-modification system, M subunit YP_498985.1 restriction modification system specificity subunit, putative YP_498986.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_498987.1 conserved hypothetical protein YP_498988.1 conserved hypothetical protein YP_498989.1 conserved hypothetical protein YP_498990.1 conserved hypothetical protein YP_498991.1 conserved hypothetical protein YP_498992.1 conserved hypothetical protein YP_498993.1 conserved hypothetical protein YP_498994.1 conserved hypothetical protein YP_498995.1 conserved hypothetical protein YP_498996.1 conserved hypothetical protein YP_498997.1 conserved hypothetical protein YP_498998.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_498999.1 conserved hypothetical protein YP_499000.1 conserved hypothetical protein YP_499001.1 conserved hypothetical protein YP_499002.1 conserved hypothetical protein YP_499003.1 conserved hypothetical protein YP_499004.1 conserved hypothetical protein YP_499005.1 conserved hypothetical protein YP_499006.1 conserved hypothetical protein YP_499007.1 trans-sulfuration enzyme family protein, putative YP_499008.1 conserved hypothetical protein YP_499009.1 ABC transporter, permease protein, putative YP_499010.1 ABC transporter, substrate-binding protein, putative YP_499011.1 autolysin precursor, putative YP_499012.1 conserved hypothetical protein YP_499013.1 MutT/nudix family protein, putative YP_499014.1 conserved hypothetical protein YP_499015.1 conserved hypothetical protein YP_499016.1 conserved hypothetical protein YP_499017.1 transcriptional regulator, lysR family, putative YP_499018.1 glutamate synthase, large subunit, putative YP_499019.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_499020.1 conserved hypothetical protein YP_499021.1 alpha amylase family protein, putative YP_499022.1 conserved hypothetical protein YP_499023.1 conserved hypothetical protein YP_499024.1 conserved hypothetical protein YP_499025.1 DNA polymerase III, gamma and tau subunits, putative YP_499026.1 conserved hypothetical protein YP_499027.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_499029.1 Orn/Lys/Arg decarboxylase, putative YP_499030.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_499031.1 conserved hypothetical protein YP_499033.1 DNA polymerase III, delta prime subunit, putative YP_499034.1 conserved hypothetical protein YP_499035.2 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA YP_499036.1 conserved hypothetical protein YP_499037.1 conserved hypothetical protein YP_499038.1 conserved hypothetical protein YP_499040.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_499041.1 conserved hypothetical protein YP_499042.1 conserved hypothetical protein YP_499043.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_499044.1 conserved hypothetical protein YP_499045.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_499047.1 conserved hypothetical protein YP_499048.1 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus YP_499049.1 conserved hypothetical protein YP_499050.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_499051.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_499053.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_499054.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_499056.1 conserved hypothetical protein YP_499057.1 conserved hypothetical protein YP_499058.1 conserved hypothetical protein YP_499059.1 conserved hypothetical protein YP_499060.1 S1 RNA binding domain protein YP_499061.1 conserved hypothetical protein YP_499063.1 conserved hypothetical protein YP_499064.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_499065.1 conserved hypothetical protein YP_499069.1 conserved hypothetical protein YP_499070.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_499071.1 conserved hypothetical protein YP_499072.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_499073.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_499074.1 conserved hypothetical protein YP_499075.1 conserved hypothetical protein YP_499076.1 UvrB/uvrC motif domain protein YP_499077.1 ATP:guanido phosphotransferase, C-terminal catalytic domain protein YP_499078.1 endopeptidase, putative YP_499080.2 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_499081.1 conserved hypothetical protein YP_499082.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_499083.1 serine acetyltransferase, putative YP_499084.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_499085.1 conserved hypothetical protein YP_499086.1 conserved hypothetical protein YP_499087.1 conserved hypothetical protein YP_499088.1 conserved hypothetical protein YP_499089.2 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_499090.1 transcription antitermination protein, putative YP_499091.1 binds directly to 23S ribosomal RNA YP_499092.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_499093.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_499094.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_499095.1 conserved hypothetical protein YP_499096.2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_499097.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_499098.1 in Bacillus subtilis this non-essential protein associates with the ribosome YP_499099.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_499100.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_499101.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_499102.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_499103.1 conserved hypothetical protein YP_499104.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_499105.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress YP_499106.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_499107.1 conserved hypothetical protein YP_499108.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_499109.1 conserved hypothetical protein YP_499110.1 haloacid dehalogenase-like hydrolase, putative YP_499111.1 conserved hypothetical protein YP_499112.1 conserved hypothetical protein YP_499113.1 conserved hypothetical protein YP_499114.1 conserved hypothetical protein YP_499115.1 conserved hypothetical protein YP_499117.1 sdrC protein, putative YP_499118.1 sdrD protein, putative YP_499119.1 conserved hypothetical protein YP_499120.1 conserved hypothetical protein YP_499121.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_499122.1 conserved hypothetical protein YP_499123.1 conserved hypothetical protein YP_499124.1 conserved hypothetical protein YP_499125.1 conserved hypothetical protein YP_499126.2 SIS domain protein YP_499127.1 hydrolase, haloacid dehalogenase-like YP_499128.1 proline/betaine transporter, putative YP_499129.1 conserved hypothetical protein YP_499130.1 acetyl-CoA acetyltransferase, putative YP_499131.1 conserved hypothetical protein YP_499132.1 conserved hypothetical protein YP_499133.1 conserved hypothetical protein YP_499135.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_499136.1 conserved hypothetical protein YP_499137.1 conserved hypothetical protein YP_499138.1 conserved hypothetical protein YP_499139.1 conserved hypothetical protein YP_499140.1 conserved hypothetical protein YP_499141.1 conserved hypothetical protein YP_499142.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_499143.1 conserved hypothetical protein YP_499144.1 mevalonate kinase, putative YP_499145.1 diphosphomevalonate decarboxylase YP_499147.1 conserved hypothetical protein YP_499148.1 conserved hypothetical protein YP_499149.1 conserved hypothetical protein YP_499150.1 conserved hypothetical protein YP_499151.1 conserved hypothetical protein YP_499152.1 conserved hypothetical protein YP_499153.1 conserved hypothetical protein YP_499154.1 conserved hypothetical protein YP_499155.1 conserved hypothetical protein YP_499157.1 conserved hypothetical protein YP_499158.1 conserved hypothetical protein YP_499161.1 conserved hypothetical protein YP_499162.1 conserved hypothetical protein YP_499163.1 conserved hypothetical protein YP_499164.1 conserved hypothetical protein YP_499165.1 conserved hypothetical protein YP_499166.1 conserved hypothetical protein YP_499167.1 conserved hypothetical protein YP_499168.1 conserved hypothetical protein YP_499169.1 conserved hypothetical protein YP_499170.1 conserved hypothetical protein YP_499171.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_499172.1 conserved hypothetical protein YP_499173.1 conserved hypothetical protein YP_499174.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_499175.1 endonuclease III, putative YP_499176.1 iron compound ABC transporter, substrate-binding protein, putative YP_499177.1 conserved hypothetical protein YP_499178.1 haloacid dehalogenase-like hydrolase, putative YP_499179.1 conserved hypothetical protein YP_499180.1 conserved hypothetical protein YP_499181.1 conserved hypothetical protein YP_499182.1 conserved hypothetical protein YP_499183.1 staphylococcal accessory regulator T, putative YP_499184.1 conserved hypothetical protein YP_499185.2 conserved hypothetical protein YP_499186.1 integrase/recombinase, putative YP_499187.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_499188.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_499189.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_499190.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifically with K+ transport YP_499191.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_499193.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_499194.1 conserved hypothetical protein YP_499195.1 ABC transporter, substrate-binding protein, putative YP_499196.1 iron (chelated) ABC transporter, permease protein, putative YP_499197.1 conserved hypothetical protein YP_499198.1 conserved hypothetical protein YP_499199.1 conserved hypothetical protein YP_499200.1 conserved hypothetical protein YP_499201.1 with TagG is involved in the export of teichoic acids YP_499202.1 teichoic acid biosynthesis protein, putative YP_499203.1 tagB protein, putative YP_499204.1 tagX protein, putative YP_499206.1 penicillin-binding protein 4, putative YP_499207.1 conserved hypothetical protein YP_499208.1 conserved hypothetical protein YP_499209.1 conserved hypothetical protein YP_499210.1 conserved hypothetical protein YP_499211.1 iron compound ABC transporter, ATP-binding protein YP_499212.1 ferrichrome transport permease fhuB, putative YP_499213.1 ferrichrome ABC transporter (permease), putative YP_499214.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_499215.1 conserved hypothetical protein YP_499216.1 conserved hypothetical protein YP_499217.1 conserved hypothetical protein YP_499218.1 conserved hypothetical protein YP_499219.1 conserved hypothetical protein YP_499221.1 conserved hypothetical protein YP_499222.1 conserved hypothetical protein YP_499223.1 conserved hypothetical protein YP_499224.1 conserved hypothetical protein YP_499225.1 conserved hypothetical protein YP_499226.1 ABC transporter ATP-binding protein, putative YP_499227.1 ABC transporter permease, putative YP_499228.1 conserved hypothetical protein YP_499229.1 conserved hypothetical protein YP_499231.1 conserved hypothetical protein YP_499232.1 conserved hypothetical protein YP_499233.1 conserved hypothetical protein YP_499234.1 conserved hypothetical protein YP_499235.1 conserved hypothetical protein YP_499236.1 conserved hypothetical protein YP_499237.1 conserved hypothetical protein YP_499238.1 conserved hypothetical protein YP_499241.1 conserved hypothetical protein YP_499242.1 conserved hypothetical protein YP_499243.1 conserved hypothetical protein YP_499244.1 conserved hypothetical protein YP_499245.1 conserved hypothetical protein YP_499246.1 conserved hypothetical protein YP_499247.1 conserved hypothetical protein YP_499248.1 conserved hypothetical protein YP_499249.1 conserved hypothetical protein YP_499250.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_499251.1 conserved hypothetical protein YP_499252.1 conserved hypothetical protein YP_499253.1 conserved hypothetical protein YP_499254.1 conserved hypothetical protein YP_499255.1 conserved hypothetical protein YP_499256.1 conserved hypothetical protein YP_499257.1 conserved hypothetical protein YP_499258.1 deoxyribodipyrimidine photolyase, putative YP_499259.1 conserved hypothetical protein YP_499260.1 conserved hypothetical protein YP_499261.1 conserved hypothetical protein YP_499262.1 quinolone resistance norA protein, putative YP_499263.1 conserved hypothetical protein YP_499264.1 conserved hypothetical protein YP_499265.1 conserved hypothetical protein YP_499266.1 fructose 1-phosphate kinase, putative YP_499267.1 fructose specific permease, putative YP_499270.1 conserved hypothetical protein YP_499271.1 conserved hypothetical protein YP_499272.1 conserved hypothetical protein YP_499273.1 sensor histidine kinase SaeS, putative YP_499274.1 response regulator, putative YP_499275.1 conserved hypothetical protein YP_499276.1 conserved hypothetical protein YP_499277.1 conserved hypothetical protein YP_499278.1 conserved hypothetical protein YP_499279.1 6-pyruvoyl tetrahydropterin synthase superfamily, putative YP_499280.1 conserved hypothetical protein YP_499281.1 para-aminobenzoate synthase, glutamine amidotransferase, component II, putative YP_499282.1 annotated as putative para-aminobenzoate synthase, component I containing frameshift in strain Col YP_499283.1 chorismate binding enzyme, putative YP_499284.1 conserved hypothetical protein YP_499285.1 conserved hypothetical protein YP_499286.1 conserved hypothetical protein YP_499287.1 conserved hypothetical protein YP_499289.1 ABC transporter, ATP-binding protein YP_499291.1 ABC transporter domain protein YP_499292.1 amino acid ABC transporter, permease protein, putative YP_499293.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_499294.1 conserved hypothetical protein YP_499295.1 conserved hypothetical protein YP_499296.1 conserved hypothetical protein YP_499298.1 conserved hypothetical protein YP_499299.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_499300.1 conserved hypothetical protein YP_499301.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_499302.1 Catalyzes the rate-limiting step in dNTP synthesis YP_499303.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_499304.1 conserved hypothetical protein YP_499305.1 conserved hypothetical protein YP_499306.1 conserved hypothetical protein YP_499307.1 conserved hypothetical protein YP_499308.1 conserved hypothetical protein YP_499309.1 conserved hypothetical protein YP_499310.1 conserved hypothetical protein YP_499311.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_499312.1 conserved hypothetical protein YP_499313.1 conserved hypothetical protein YP_499314.1 conserved hypothetical protein YP_499315.1 conserved hypothetical protein YP_499316.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_499317.1 conserved hypothetical protein YP_499318.1 conserved hypothetical protein YP_499319.1 conserved hypothetical protein YP_499320.1 conserved hypothetical protein YP_499321.1 conserved hypothetical protein YP_499322.1 conserved hypothetical protein YP_499323.1 conserved hypothetical protein YP_499324.1 conserved hypothetical protein YP_499325.1 conserved hypothetical protein YP_499326.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_499327.1 conserved hypothetical protein YP_499328.1 peptide chain release factor 2, putative YP_499329.1 conserved hypothetical protein YP_499330.1 LysM domain protein YP_499331.1 conserved hypothetical protein YP_499332.1 conserved hypothetical protein YP_499333.1 excinuclease ABC, B subunit YP_499334.1 conserved hypothetical protein YP_499336.1 excinuclease ABC subunit B, putative YP_499337.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_499338.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_499339.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_499340.1 conserved hypothetical protein YP_499341.1 conserved hypothetical protein YP_499343.1 conserved hypothetical protein YP_499344.2 conserved hypothetical protein YP_499345.1 conserved hypothetical protein YP_499346.1 conserved hypothetical protein YP_499347.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_499348.1 conserved hypothetical protein YP_499349.1 conserved hypothetical protein YP_499351.1 glyceraldehyde-3-phosphate dehydrogenase, type I YP_499352.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_499353.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_499354.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_499355.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_499356.1 conserved hypothetical protein YP_499357.2 preprotein translocase, SecG subunit YP_499358.1 carboxylesterase precursor, putative YP_499359.1 ribonuclease R, putative YP_499360.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_499362.1 conserved hypothetical protein YP_499363.1 conserved hypothetical protein YP_499364.1 conserved hypothetical protein YP_499365.1 conserved hypothetical protein YP_499366.1 conserved hypothetical protein YP_499367.1 conserved hypothetical protein YP_499371.1 extracellular matrix and plasma binding protein, putative YP_499372.1 conserved hypothetical protein YP_499373.1 thermonuclease precursor YP_499374.1 conserved hypothetical protein YP_499375.1 conserved hypothetical protein YP_499376.1 conserved hypothetical protein YP_499377.1 conserved hypothetical protein YP_499378.1 conserved hypothetical protein YP_499379.1 conserved hypothetical protein YP_499380.1 conserved hypothetical protein YP_499381.1 conserved hypothetical protein YP_499382.1 conserved hypothetical protein YP_499383.1 conserved hypothetical protein YP_499384.1 conserved hypothetical protein YP_499385.1 conserved hypothetical protein YP_499386.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_499387.1 conserved hypothetical protein YP_499388.1 thioredoxin, putative YP_499389.1 conserved hypothetical protein YP_499390.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_499391.1 conserved hypothetical protein YP_499392.1 conserved hypothetical protein YP_499393.1 conserved hypothetical protein YP_499394.1 conserved hypothetical protein YP_499395.1 conserved hypothetical protein YP_499396.1 ABC transporter, ATP-binding protein, putative YP_499397.1 conserved hypothetical protein YP_499398.1 conserved hypothetical protein YP_499399.1 conserved hypothetical protein YP_499400.1 conserved hypothetical protein YP_499401.1 ABC transporter, ATP-binding protein, putative YP_499402.1 conserved hypothetical protein YP_499403.1 aminotransferase, class V superfamily, putative YP_499404.1 conserved hypothetical protein YP_499405.1 conserved hypothetical protein YP_499406.1 conserved hypothetical protein YP_499407.1 conserved hypothetical protein YP_499408.1 conserved hypothetical protein YP_499409.1 conserved hypothetical protein YP_499410.1 conserved hypothetical protein YP_499411.1 conserved hypothetical protein YP_499412.1 conserved hypothetical protein YP_499414.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_499415.1 conserved hypothetical protein YP_499416.1 conserved hypothetical protein YP_499417.1 conserved hypothetical protein YP_499418.1 conserved hypothetical protein YP_499419.1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein YP_499420.1 conserved hypothetical protein YP_499421.2 conserved hypothetical protein YP_499422.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid YP_499423.1 dltB protein, putative YP_499424.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid YP_499426.1 conserved hypothetical protein YP_499427.1 conserved hypothetical protein YP_499428.1 conserved hypothetical protein YP_499429.1 conserved hypothetical protein YP_499430.1 conserved hypothetical protein YP_499431.1 conserved hypothetical protein YP_499432.1 probable cytosol aminopeptidase YP_499433.1 conserved hypothetical protein YP_499434.1 conserved hypothetical protein YP_499435.1 conserved hypothetical protein YP_499436.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_499437.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_499438.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_499439.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_499440.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_499441.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport YP_499442.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_499443.1 conserved hypothetical protein YP_499444.1 peptidyl-prolyl cis-trans isomerase, cyclophilin-type, putative YP_499445.1 conserved hypothetical protein YP_499446.1 FMN oxidoreductase, putative YP_499447.1 ornithine aminotransferase, putative YP_499448.1 glutamate dehydrogenase, NAD-specific, putative YP_499449.1 conserved hypothetical protein YP_499450.1 conserved hypothetical protein YP_499451.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_499452.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_499453.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_499454.1 conserved hypothetical protein YP_499455.1 Signal peptidase IA, putative YP_499456.1 Signal peptidase IB, putative YP_499457.1 exonuclease RexB, putative YP_499458.1 ATP-dependent nuclease subunit A, putative YP_499459.1 conserved hypothetical protein YP_499460.1 conserved hypothetical protein YP_499461.1 NADPH-dependent; catalyzes the reduction of coenzyme A disulfide YP_499462.1 conserved hypothetical protein YP_499463.1 conserved hypothetical protein YP_499464.1 conserved hypothetical protein YP_499465.1 ATP-dependent Clp protease, ATP-binding subunit ClpB YP_499466.1 conserved hypothetical protein YP_499467.1 2-isopropylmalate synthase, putative YP_499468.1 conserved hypothetical protein YP_499469.1 conserved hypothetical protein YP_499470.1 conserved hypothetical protein YP_499472.1 conserved hypothetical protein YP_499473.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_499474.1 3-oxoacyl- synthase, putative YP_499475.1 conserved hypothetical protein YP_499476.1 conserved hypothetical protein YP_499477.1 conserved hypothetical protein YP_499478.1 conserved hypothetical protein YP_499479.1 oligopeptide ABC transporter, ATP-binding protein, putative YP_499480.1 oligopeptide ABC transporter, substrate-binding protein, putative YP_499481.1 oligopeptide ABC transporter, substrate-binding protein, putative YP_499482.1 oligopeptide ABC transporter, ATP-binding protein, putative YP_499483.1 oligopeptide ABC transporter, ATP-binding protein, putative YP_499484.1 oligopeptide ABC transporter, permease protein, putative YP_499485.1 oligopeptide ABC transporter, permease protein, putative YP_499486.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_499487.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress YP_499488.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_499489.1 conserved hypothetical protein YP_499491.1 conserved hypothetical protein YP_499492.1 conserved hypothetical protein YP_499493.1 conserved hypothetical protein YP_499494.1 conserved hypothetical protein YP_499495.1 GTP pyrophosphokinase, putative YP_499496.1 catalyzes the phosphorylation of NAD to NADP YP_499497.1 conserved hypothetical protein YP_499499.1 conserved hypothetical protein YP_499500.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_499501.1 conserved hypothetical protein YP_499502.1 conserved hypothetical protein YP_499503.1 conserved hypothetical protein YP_499504.1 similar to 2'-5' RNA ligase YP_499505.1 conserved hypothetical protein YP_499506.1 processive; catalyzes the formation of mono-, di- and tri-glucosyldiacylglycerol by the progressive transfer of glucosyl residues to diacylglycerol; involved in the formation of membrane glycolipids YP_499507.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine YP_499508.1 conserved hypothetical protein YP_499509.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_499510.1 conserved hypothetical protein YP_499511.1 serine protease HtrA, putative YP_499512.1 conserved hypothetical protein YP_499513.1 conserved hypothetical protein YP_499514.1 conserved hypothetical protein YP_499515.1 conserved hypothetical protein YP_499516.1 lipoyltransferase and lipoate-protein ligase, putative YP_499517.1 conserved hypothetical protein YP_499518.1 conserved hypothetical protein YP_499519.1 conserved hypothetical protein YP_499521.1 conserved hypothetical protein YP_499522.1 conserved hypothetical protein YP_499523.1 ABC transporter, ATP-binding protein, putative YP_499524.1 conserved hypothetical protein YP_499525.1 conserved hypothetical protein YP_499528.1 conserved hypothetical protein YP_499529.1 conserved hypothetical protein YP_499530.1 conserved hypothetical protein YP_499531.1 conserved hypothetical protein YP_499532.1 conserved hypothetical protein YP_499533.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_499534.1 conserved hypothetical protein YP_499535.1 conserved hypothetical protein YP_499537.1 conserved hypothetical protein YP_499538.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_499539.1 cysteine protease, putative YP_499540.1 cysteine protease precursor, putative YP_499541.1 glutamyl endopeptidase precursor, putative YP_499542.1 conserved hypothetical protein YP_499543.1 conserved hypothetical protein YP_499544.1 transcriptional regulator, MarR family, putative YP_499545.1 conserved hypothetical protein YP_499546.1 bifunctional autolysin precursor, putative YP_499547.1 conserved hypothetical protein YP_499548.1 conserved hypothetical protein YP_499549.1 conserved hypothetical protein YP_499550.1 fmt protein, putative YP_499551.1 quinol oxidase, subunit IV, putative YP_499552.1 cytochrome c oxidase subunit III, putative YP_499553.1 quinol oxidase, subunit I YP_499554.1 quinol oxidase AA3, subunit II, putative YP_499556.1 conserved hypothetical protein YP_499557.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_499558.1 phosphoribosylaminoimidazole carboxylase, catalytic subunit YP_499559.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_499560.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_499561.1 phosphoribosylformylglycinamidine synthase, PurS protein YP_499562.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_499563.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_499564.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_499565.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_499566.1 phosphoribosylglycinamide formyltransferase, putative YP_499567.1 involved in de novo purine biosynthesis YP_499568.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_499569.1 conserved hypothetical protein YP_499570.1 conserved hypothetical protein YP_499571.1 conserved hypothetical protein YP_499574.1 conserved hypothetical protein YP_499575.1 conserved hypothetical protein YP_499576.1 conserved hypothetical protein YP_499577.1 phosphocarrier protein hpr, putative YP_499579.1 conserved hypothetical protein YP_499580.1 cytochrome d ubiquinol oxidase, subunit I, putative YP_499581.1 cytochrome d ubiquinol oxidase, subunit II, putative YP_499582.1 conserved hypothetical protein YP_499583.1 conserved hypothetical protein YP_499584.1 conserved hypothetical protein YP_499585.1 conserved hypothetical protein YP_499587.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_499588.1 conserved hypothetical protein YP_499589.1 pyruvate dehydrogenase complex, E1 component, alpha subunit, putative YP_499590.1 pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit, putative YP_499591.1 dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex E2, putative YP_499592.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_499593.1 conserved hypothetical protein YP_499594.1 conserved hypothetical protein YP_499595.1 ABC transporter domain protein YP_499596.1 spermidine/putrescine ABC transporter, permease protein, putative YP_499597.1 spermidine/putrescine ABC transporter, permease protein, putative YP_499598.1 spermidine/putrescine ABC transporter, spermidine/putrescine-binding protein, putative YP_499599.1 conserved hypothetical protein YP_499600.1 conserved hypothetical protein YP_499601.1 conserved hypothetical protein YP_499602.1 conserved hypothetical protein YP_499603.1 inositol monophosphatase family protein, putative YP_499605.1 GTP-binding protein TypA, putative YP_499606.1 conserved hypothetical protein YP_499607.1 conserved hypothetical protein YP_499608.1 depletion of this protein in Bacillus subtilis results in defects in cell morphology; crystal structure of Staphylococcus protein shows homodimer; putative ligand binding protein YP_499609.1 conserved hypothetical protein YP_499610.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_499611.1 heme A synthase, putative YP_499612.1 converts protoheme IX and farnesyl diphosphate to heme O YP_499613.1 conserved hypothetical protein YP_499614.1 conserved hypothetical protein YP_499615.2 conserved hypothetical protein YP_499616.1 conserved hypothetical protein YP_499617.1 glycerophosphoryl diester phosphodiesterase, putative YP_499618.1 conserved hypothetical protein YP_499619.1 conserved hypothetical protein YP_499620.1 conserved hypothetical protein YP_499621.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_499622.1 conserved hypothetical protein YP_499623.1 conserved hypothetical protein YP_499627.1 conserved hypothetical protein YP_499628.1 conserved hypothetical protein YP_499629.1 conserved hypothetical protein YP_499630.1 conserved hypothetical protein YP_499631.1 iron compound ABC transporter, permease protein, putative YP_499632.1 iron compound ABC transporter, permease protein YP_499633.1 conserved hypothetical protein YP_499634.1 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source YP_499635.1 conserved hypothetical protein YP_499636.1 conserved hypothetical protein YP_499637.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_499638.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_499639.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_499640.1 conserved hypothetical protein YP_499641.1 conserved hypothetical protein YP_499642.1 DNA-dependent DNA polymerase beta chain, putative YP_499643.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_499645.1 conserved hypothetical protein YP_499646.2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_499647.1 succinate dehydrogenase cytochrome b-558 subunit, putative YP_499648.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_499649.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_499650.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_499651.1 hydrolyzes non-standard nucleotides such as xanthine and inosine YP_499652.1 conserved hypothetical protein YP_499653.1 conserved hypothetical protein YP_499654.1 fibrinogen-binding protein-related YP_499656.1 FLIPr; secreted protein that blocks the formyl peptide receptor-like 1 (FPRL1) found in neutrophils, monocytes, B cells, and NK cells; inhibits the binding of chemoattractants (such as formylated peptides) to FPRL1, which initiates the phagocyte mobilization towards the infection site YP_499657.1 conserved hypothetical protein YP_499659.1 conserved hypothetical protein YP_499660.1 conserved hypothetical protein YP_499662.1 conserved hypothetical protein YP_499663.1 conserved hypothetical protein YP_499664.1 conserved hypothetical protein YP_499665.1 alpha-hemolysin precursor YP_499666.1 conserved hypothetical protein YP_499667.1 conserved hypothetical protein YP_499668.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_499669.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_499670.1 these proteins share structural homology to known superantigen proteins but do not exhibit any of the properties expected such as histocompatibility complex class II binding or broad T-cell activation YP_499671.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_499672.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_499673.1 conserved hypothetical protein YP_499674.1 conserved hypothetical protein YP_499675.1 conserved hypothetical protein YP_499676.1 conserved hypothetical protein YP_499677.1 conserved hypothetical protein YP_499678.1 conserved hypothetical protein YP_499679.1 conserved hypothetical protein YP_499680.1 conserved hypothetical protein YP_499681.1 conserved hypothetical protein YP_499683.1 conserved hypothetical protein YP_499684.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_499686.1 conserved hypothetical protein YP_499688.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_499689.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_499690.1 cell division protein, putative YP_499691.1 cell division protein, putative YP_499692.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_499693.1 conserved hypothetical protein YP_499694.1 conserved hypothetical protein YP_499695.1 conserved hypothetical protein YP_499696.1 conserved hypothetical protein YP_499697.1 conserved hypothetical protein YP_499698.1 conserved hypothetical protein YP_499699.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_499700.1 conserved hypothetical protein YP_499702.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_499703.1 conserved hypothetical protein YP_499704.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_499705.1 uracil permease, putative YP_499706.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_499707.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_499708.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_499709.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_499710.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_499711.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_499712.1 conserved hypothetical protein YP_499713.1 conserved hypothetical protein YP_499714.1 fibronectin-binding protein A-related YP_499715.1 Essential for recycling GMP and indirectly, cGMP YP_499716.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_499717.1 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase YP_499719.1 conserved hypothetical protein YP_499720.1 conserved hypothetical protein YP_499721.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_499724.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_499725.1 conserved hypothetical protein YP_499726.1 conserved hypothetical protein YP_499727.2 conserved hypothetical protein YP_499729.1 conserved hypothetical protein YP_499730.1 required for 70S ribosome assembly YP_499731.1 conserved hypothetical protein YP_499732.1 conserved hypothetical protein YP_499733.1 catalyzes branch migration in Holliday junction intermediates YP_499734.1 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria YP_499735.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_499737.1 3-oxoacyl-(acyl-carrier-protein) reductase, putative YP_499738.1 conserved hypothetical protein YP_499739.1 carries the fatty acid chain in fatty acid biosynthesis YP_499740.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_499741.1 SMC family, C-terminal domain family YP_499743.1 conserved hypothetical protein YP_499745.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_499746.1 Essential for efficient processing of 16S rRNA YP_499747.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_499748.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_499750.1 conserved hypothetical protein YP_499751.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_499752.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_499753.1 catalyzes the interconversion of succinyl-CoA and succinate YP_499754.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_499755.1 cell wall hydrolase, putative YP_499756.1 conserved hypothetical protein YP_499757.1 conserved hypothetical protein YP_499758.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_499759.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_499760.1 site-specific recombinase, putative YP_499761.1 heat shock protein involved in degradation of misfolded proteins YP_499762.1 heat shock protein involved in degradation of misfolded proteins YP_499763.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor YP_499764.1 conserved hypothetical protein YP_499766.1 conserved hypothetical protein YP_499767.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_499768.1 Catalyzes the phosphorylation of UMP to UDP YP_499769.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_499770.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_499771.1 conserved hypothetical protein YP_499772.1 conserved hypothetical protein YP_499773.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_499774.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_499775.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_499776.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_499777.1 conserved hypothetical protein YP_499778.1 conserved hypothetical protein YP_499779.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_499780.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_499781.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_499783.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_499784.1 polyribonucleotide nucleotidyltransferase, putative YP_499785.1 conserved hypothetical protein YP_499786.1 conserved hypothetical protein YP_499787.1 conserved hypothetical protein YP_499788.1 conserved hypothetical protein YP_499789.1 conserved hypothetical protein YP_499790.1 conserved hypothetical protein YP_499791.1 conserved hypothetical protein YP_499792.1 conserved hypothetical protein YP_499795.2 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_499796.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_499797.1 conserved hypothetical protein YP_499798.1 conserved hypothetical protein YP_499799.1 conserved hypothetical protein YP_499800.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin YP_499801.1 conserved hypothetical protein YP_499802.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_499803.1 conserved hypothetical protein YP_499804.1 conserved hypothetical protein YP_499805.1 This protein performs the mismatch recognition step during the DNA repair process YP_499806.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_499807.1 glycerol uptake operon antiterminator regulatory protein, putative YP_499808.1 conserved hypothetical protein YP_499809.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_499810.1 conserved hypothetical protein YP_499811.1 hydrolase, alpha/beta fold family domain protein YP_499812.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_499813.1 host factor 1 protein, putative YP_499814.1 conserved hypothetical protein YP_499815.1 conserved hypothetical protein YP_499816.1 conserved hypothetical protein YP_499817.1 conserved hypothetical protein YP_499818.1 glutamine synthetase, type I YP_499819.1 conserved hypothetical protein YP_499820.1 conserved hypothetical protein YP_499821.1 conserved hypothetical protein YP_499822.1 conserved hypothetical protein YP_499823.1 conserved hypothetical protein YP_499824.1 conserved hypothetical protein YP_499825.1 conserved hypothetical protein YP_499826.1 conserved hypothetical protein YP_499827.1 conserved hypothetical protein YP_499828.1 conserved hypothetical protein YP_499830.1 conserved hypothetical protein YP_499831.1 conserved hypothetical protein YP_499832.1 conserved hypothetical protein YP_499835.1 conserved hypothetical protein YP_499836.1 conserved hypothetical protein YP_499837.1 conserved hypothetical protein YP_499838.1 conserved hypothetical protein YP_499840.1 cardiolipin synthetase, putative YP_499841.1 ABC transporter, ATP-binding protein, putative YP_499842.1 conserved hypothetical protein YP_499843.1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein YP_499844.1 conserved hypothetical protein YP_499845.1 conserved hypothetical protein YP_499846.1 conserved hypothetical protein YP_499847.1 conserved hypothetical protein YP_499848.1 conserved hypothetical protein YP_499849.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive YP_499850.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_499851.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_499852.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_499853.1 conserved hypothetical protein YP_499854.1 conserved hypothetical protein YP_499856.1 conserved hypothetical protein YP_499858.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_499859.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_499860.1 guanosine monophosphate reductase YP_499861.1 conserved hypothetical protein YP_499862.1 conserved hypothetical protein YP_499863.1 Represses a number of genes involved in the response to DNA damage YP_499864.1 conserved hypothetical protein YP_499865.1 conserved hypothetical protein YP_499867.1 conserved hypothetical protein YP_499868.1 conserved hypothetical protein YP_499869.1 conserved hypothetical protein YP_499870.1 conserved hypothetical protein YP_499874.1 glycine betaine transporter, putative YP_499875.1 Catalyzes the conversion of citrate to isocitrate YP_499876.1 conserved hypothetical protein YP_499877.1 conserved hypothetical protein YP_499878.1 conserved hypothetical protein YP_499879.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_499880.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_499881.1 conserved hypothetical protein YP_499882.1 sodium:alanine symporter family protein, putative YP_499883.1 transcriptional antiterminator YP_499884.1 conserved hypothetical protein YP_499885.1 conserved hypothetical protein YP_499886.1 conserved hypothetical protein YP_499887.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_499888.1 transcriptional regulator, putative YP_499889.1 4-oxalocrotonate tautomerase, putative YP_499890.1 conserved hypothetical protein YP_499891.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_499892.1 conserved hypothetical protein YP_499893.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_499894.1 anthranilate synthase component II, putative YP_499895.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_499896.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_499897.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_499898.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_499899.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_499900.1 methicillin resistance factor, FemA, putative YP_499901.1 methicillin resistance factor, putative YP_499902.1 conserved hypothetical protein YP_499903.1 conserved hypothetical protein YP_499904.1 oligopeptide ABC transporter, ATP-binding protein, putative YP_499905.1 peptide ABC transporter, ATP-binding protein, putative YP_499906.1 oligopeptide transporter putative membrane permease domain YP_499907.1 oligopeptide transporter putative membrane permease domain YP_499909.1 conserved hypothetical protein YP_499910.1 conserved hypothetical protein YP_499911.1 PhoU family, putative YP_499912.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_499913.1 phosphate ABC transporter, permease protein, putative YP_499914.1 conserved hypothetical protein YP_499916.1 phosphate ABC transporter, periplasmic phosphate-binding protein, putative YP_499919.1 conserved hypothetical protein YP_499920.1 ABC transporter, ATP-binding protein, putative YP_499921.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_499922.1 aspartate-semialdehyde dehydrogenase YP_499923.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_499924.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_499925.1 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase, putative YP_499926.1 conserved hypothetical protein YP_499927.1 alanine racemase, putative YP_499929.1 conserved hypothetical protein YP_499930.1 cold shock protein, putative YP_499932.1 conserved hypothetical protein YP_499933.1 catalyzes the hydrolysis of acylphosphate YP_499934.1 conserved hypothetical protein YP_499935.1 conserved hypothetical protein YP_499939.1 conserved hypothetical protein YP_499940.1 conserved hypothetical protein YP_499941.2 conserved hypothetical protein YP_499942.1 conserved hypothetical protein YP_499943.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_499944.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_499945.1 conserved hypothetical protein YP_499946.1 DNA-binding response regulator, putative YP_499948.1 conserved hypothetical protein YP_499949.1 conserved hypothetical protein YP_499950.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_499951.1 conserved hypothetical protein YP_499952.1 conserved hypothetical protein YP_499954.1 conserved hypothetical protein YP_499955.1 phosphotransferase system enzyme IIA, putative YP_499956.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_499957.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_499958.1 conserved hypothetical protein YP_499960.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_499961.1 conserved hypothetical protein YP_499962.1 conserved hypothetical protein YP_499963.1 conserved hypothetical protein YP_499964.1 conserved hypothetical protein YP_499965.1 conserved hypothetical protein YP_499966.1 conserved hypothetical protein YP_499968.1 conserved hypothetical protein YP_499969.1 conserved hypothetical protein YP_499970.1 conserved hypothetical protein YP_499971.1 conserved hypothetical protein YP_499972.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_499974.1 conserved hypothetical protein YP_499975.1 conserved hypothetical protein YP_499976.1 conserved hypothetical protein YP_499978.1 conserved hypothetical protein YP_499979.1 conserved hypothetical protein YP_499980.1 conserved hypothetical protein YP_499981.1 conserved hypothetical protein YP_499982.1 conserved hypothetical protein YP_499984.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_499986.1 conserved hypothetical protein YP_499987.1 endonuclease III, putative YP_499988.1 conserved hypothetical protein YP_499989.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_499990.1 DnaQ family exonuclease/DinG family helicase, putative YP_499991.1 BirA bifunctional protein, putative YP_499992.2 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity YP_499993.1 conserved hypothetical protein YP_499994.1 conserved hypothetical protein YP_499995.1 conserved hypothetical protein YP_499996.1 conserved hypothetical protein YP_499997.1 conserved hypothetical protein YP_499998.1 conserved hypothetical protein YP_499999.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_500000.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_500001.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_500002.1 conserved hypothetical protein YP_500003.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_500004.1 heptaprenyl diphosphate syntase component II, putative YP_500005.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_500006.1 conserved hypothetical protein YP_500008.1 DNA-binding protein HU, putative YP_500009.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_500010.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_500011.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_500014.1 conserved hypothetical protein YP_500015.2 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_500016.1 L-asparaginase, putative YP_500017.1 conserved hypothetical protein YP_500018.1 conserved hypothetical protein YP_500020.1 ATP-dependent DNA helicase RecQ, putative YP_500021.1 conserved hypothetical protein YP_500022.1 ferredoxin, putative YP_500023.1 conserved hypothetical protein YP_500024.1 conserved hypothetical protein YP_500025.1 conserved hypothetical protein YP_500026.1 conserved hypothetical protein YP_500027.1 conserved hypothetical protein YP_500028.1 conserved hypothetical protein YP_500029.1 conserved hypothetical protein YP_500030.1 hypothetical phage protein YP_500032.1 petidoglycan hydrolase, putative YP_500034.1 conserved hypothetical phage protein YP_500035.1 conserved hypothetical phage protein YP_500039.1 conserved hypothetical phage protein YP_500042.1 phage tail tape meausure protein, TP901 family, core region domain protein YP_500043.1 conserved hypothetical phage protein YP_500044.1 conserved hypothetical phage protein YP_500045.1 bacteriophage L54a, bacterial Ig-like domain group 2 family protein YP_500047.1 conserved hypothetical phage protein YP_500050.1 conserved hypothetical phage protein YP_500051.1 conserved hypothetical phage protein YP_500053.1 phage portal protein, HK97 family YP_500054.1 phage terminase, large subunit, putative YP_500055.1 terminase-small subunit YP_500056.1 bacteriophage L54a, HNH endonuclease family protein YP_500057.1 conserved hypothetical phage protein YP_500058.1 SNF2 family N-terminal domain protein YP_500059.1 phi related protein YP_500060.1 hypothetical phage protein YP_500061.1 conserved hypothetical phage protein YP_500062.1 conserved hypothetical phage protein YP_500063.1 conserved hypothetical phage protein YP_500064.1 conserved hypothetical phage protein YP_500065.1 transcriptional activator rinB-related protein YP_500066.1 conserved hypothetical phage protein YP_500067.1 conserved hypothetical phage protein YP_500068.1 bacteriophage L54a, deoxyuridine 5-triphosphate nucleotidohydrolase YP_500071.1 conserved hypothetical phage protein YP_500073.1 conserved hypothetical phage protein YP_500075.1 conserved hypothetical phage protein YP_500076.1 conserved hypothetical phage protein YP_500078.1 ETA orf 26-like protein-related protein YP_500080.1 phage-related protein YP_500082.1 conserved hypothetical phage protein YP_500083.1 conserved hypothetical phage protein YP_500084.1 conserved hypothetical phage protein YP_500086.1 SLT orf 71-like protein-related protein YP_500087.1 conserved hypothetical phage protein YP_500088.1 conserved hypothetical phage protein YP_500089.1 Helix-turn-helix domain protein YP_500090.1 hypothetical phage protein YP_500091.1 Helix-turn-helix domain protein YP_500092.1 exonuclease family YP_500093.1 conserved hypothetical phage protein YP_500094.1 conserved hypothetical phage protein YP_500095.1 hypothetical phage protein YP_500098.1 conserved hypothetical phage protein YP_500099.1 conserved hypothetical protein YP_500100.1 staphylococcal respiratory response protein SrrB, putative YP_500101.1 DNA-binding response regulator, putative YP_500102.1 ribosomal large subunit pseudouridine synthase B, putative YP_500103.1 conserved hypothetical protein YP_500104.1 conserved hypothetical protein YP_500105.1 conserved hypothetical protein YP_500107.1 transcriptional regulator, Fur, putative YP_500108.1 NUDIX domain protein YP_500109.1 conserved hypothetical protein YP_500110.1 conserved hypothetical protein YP_500111.1 conserved hypothetical protein YP_500114.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_500115.1 conserved hypothetical protein YP_500116.1 alpha-glucosidase, putative YP_500117.1 transcriptional regulator, putative YP_500119.1 conserved hypothetical protein YP_500120.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_500121.1 peptidase T, putative YP_500122.1 conserved hypothetical protein YP_500124.1 conserved hypothetical protein YP_500125.1 conserved hypothetical protein YP_500126.1 2-oxoisovalerate dehydrogenase, E2 component, dihydrolipoamide acetyltransferase, putative YP_500127.1 2-oxoisovalerate dehydrogenase, E1 component, beta subunit, putative YP_500128.1 2-oxoisovalerate dehydrogenase, E1 component, alpha subunit, putative YP_500131.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_500132.1 geranyltranstransferase, putative YP_500133.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_500134.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_500135.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_500136.1 conserved hypothetical protein YP_500137.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_500138.1 acetyl-CoA carboxylase, biotin carboxyl carrier protein YP_500139.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_500140.1 proline dipeptidase, putative YP_500141.1 conserved hypothetical protein YP_500142.1 conserved hypothetical protein YP_500143.1 conserved hypothetical protein YP_500144.1 conserved hypothetical protein YP_500145.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_500146.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_500147.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_500148.1 shikimate kinase, putative YP_500150.2 conserved hypothetical protein YP_500151.1 conserved hypothetical protein YP_500152.1 conserved hypothetical protein YP_500153.1 conserved hypothetical protein YP_500154.1 conserved hypothetical protein YP_500155.1 conserved hypothetical protein YP_500156.1 conserved hypothetical protein YP_500157.1 conserved hypothetical protein YP_500158.1 glucokinase, putative YP_500159.1 conserved hypothetical protein YP_500162.1 conserved hypothetical protein YP_500163.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_500165.1 superoxide dismutase, Mn, putative YP_500166.1 conserved hypothetical protein YP_500167.1 conserved hypothetical protein YP_500168.1 ABC transporter, putative YP_500169.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_500170.1 conserved hypothetical protein YP_500171.1 conserved hypothetical protein YP_500172.1 conserved hypothetical protein YP_500173.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_500174.1 DNA primase, putative YP_500175.1 conserved hypothetical protein YP_500176.1 CBS domain protein YP_500177.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_500178.1 conserved hypothetical protein YP_500179.2 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_500182.1 diacylglycerol kinase, putative YP_500183.1 conserved hypothetical protein YP_500184.1 conserved hypothetical protein YP_500185.1 conserved hypothetical protein YP_500186.1 conserved hypothetical protein YP_500187.1 conserved hypothetical protein YP_500188.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_500189.1 conserved hypothetical protein YP_500190.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_500191.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_500192.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_500193.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_500194.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_500196.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_500197.1 conserved hypothetical protein YP_500198.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_500199.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_500200.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_500202.1 conserved hypothetical protein YP_500203.1 conserved hypothetical protein YP_500204.1 conserved hypothetical protein YP_500205.1 conserved hypothetical protein YP_500206.1 conserved hypothetical protein YP_500208.1 conserved hypothetical protein YP_500210.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis YP_500211.1 conserved hypothetical protein YP_500214.1 conserved hypothetical protein YP_500216.1 conserved hypothetical protein YP_500217.1 conserved hypothetical protein YP_500218.1 conserved hypothetical protein YP_500219.1 acetyl-CoA carboxylase, biotin carboxylase, putative YP_500220.1 acetyl-CoA carboxylase, biotin carboxyl carrier protein, putative YP_500221.1 conserved hypothetical protein YP_500222.1 conserved hypothetical protein YP_500223.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_500224.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_500225.1 conserved hypothetical protein YP_500226.1 conserved hypothetical protein YP_500227.1 conserved hypothetical protein YP_500228.1 conserved hypothetical protein YP_500229.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_500230.1 conserved hypothetical protein YP_500231.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_500232.1 conserved hypothetical protein YP_500233.1 conserved hypothetical protein YP_500236.1 conserved hypothetical protein YP_500237.1 conserved hypothetical protein YP_500238.1 conserved hypothetical protein YP_500239.1 conserved hypothetical protein YP_500242.2 conserved hypothetical protein YP_500243.1 conserved hypothetical protein YP_500244.1 conserved hypothetical protein YP_500245.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_500246.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_500247.1 conserved hypothetical protein YP_500248.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_500250.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_500251.1 conserved hypothetical protein YP_500252.2 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_500253.1 preprotein translocase, YajC subunit YP_500254.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_500255.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_500256.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_500257.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_500258.1 ACT domain protein YP_500259.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_500260.1 involved in the peptidyltransferase reaction during translation YP_500261.1 conserved hypothetical protein YP_500262.1 ribosomal protein L21 YP_500263.1 conserved hypothetical protein YP_500264.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_500265.1 conserved hypothetical protein YP_500266.1 conserved hypothetical protein YP_500267.1 conserved hypothetical protein YP_500268.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_500269.1 conserved hypothetical protein YP_500271.1 folylpolyglutamate synthase/dihydrofolate synthase, putative YP_500272.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_500273.1 conserved hypothetical protein YP_500274.1 conserved hypothetical protein YP_500275.1 conserved hypothetical protein YP_500276.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_500277.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_500278.1 uroporphyrinogen-III synthase, putative YP_500279.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_500280.1 conserved hypothetical protein YP_500281.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_500282.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_500283.1 binds and unfolds substrates as part of the ClpXP protease YP_500284.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_500286.1 conserved hypothetical protein YP_500287.1 conserved hypothetical protein YP_500289.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_500290.1 ribosomal protein L35 YP_500291.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_500292.1 conserved hypothetical protein YP_500293.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_500294.1 conserved hypothetical protein YP_500295.1 Primosomal protein that may act to load helicase DnaC during DNA replication YP_500296.1 conserved hypothetical protein YP_500297.1 conserved hypothetical protein YP_500298.1 glyceraldehyde-3-phosphate dehydrogenase, type I YP_500299.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_500302.1 conserved hypothetical protein YP_500303.1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein YP_500304.1 two-component response regulator, putative YP_500306.1 Converts isocitrate to alpha ketoglutarate YP_500307.1 conserved hypothetical protein YP_500308.1 conserved hypothetical protein YP_500312.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_500313.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_500314.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_500315.1 NADP-dependent malic enzyme, putative YP_500316.1 DNA polymerase III, alpha subunit superfamily YP_500317.1 conserved hypothetical protein YP_500318.1 conserved hypothetical protein YP_500319.1 conserved hypothetical protein YP_500320.1 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins YP_500321.1 conserved hypothetical protein YP_500322.1 conserved hypothetical protein YP_500324.1 conserved hypothetical protein YP_500325.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_500326.1 conserved hypothetical protein YP_500327.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_500328.1 conserved hypothetical protein YP_500329.1 Required for the synthesis of the thiazole moiety YP_500330.1 conserved hypothetical protein YP_500331.1 conserved hypothetical protein YP_500332.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_500333.1 GAF domain protein YP_500334.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_500336.1 conserved hypothetical protein YP_500337.1 conserved hypothetical protein YP_500338.1 conserved hypothetical protein YP_500339.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_500341.1 conserved hypothetical protein YP_500342.1 conserved hypothetical protein YP_500343.1 1-acyl-sn-glycerol-3-phosphate acyltransferases domain protein YP_500344.1 conserved hypothetical protein YP_500346.1 transglycosylase domain protein YP_500348.1 conserved hypothetical protein YP_500349.1 conserved hypothetical protein YP_500350.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_500351.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_500352.1 conserved hypothetical protein YP_500353.1 conserved hypothetical protein YP_500356.1 catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate YP_500358.1 conserved hypothetical protein YP_500359.1 conserved hypothetical protein YP_500360.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_500361.1 conserved hypothetical protein YP_500362.1 conserved hypothetical protein YP_500363.1 conserved hypothetical protein YP_500364.1 conserved hypothetical protein YP_500365.1 conserved hypothetical protein YP_500366.1 conserved hypothetical protein YP_500367.1 conserved hypothetical protein YP_500368.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_500369.1 conserved hypothetical protein YP_500370.1 D-amino acid aminotransferase YP_500371.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases YP_500372.1 conserved hypothetical protein YP_500373.1 ribosomal small subunit pseudouridine synthase A, putative YP_500374.1 polysaccharide biosynthesis protein, putative YP_500375.1 conserved hypothetical protein YP_500376.1 conserved hypothetical protein YP_500377.1 conserved hypothetical protein YP_500378.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_500379.1 conserved hypothetical protein YP_500380.1 conserved hypothetical protein YP_500381.1 conserved hypothetical protein YP_500385.1 conserved hypothetical protein YP_500386.1 conserved hypothetical protein YP_500387.1 conserved hypothetical protein YP_500388.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_500389.1 riboflavin biosynthesis protein, putative YP_500390.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_500392.1 conserved hypothetical protein YP_500394.1 arsenical pump membrane protein subfamily YP_500395.1 catalyzes the reduction of arsenate to arsenite; also can dephosphorylate tyrosine phosphorylated proteins, aryl phosphates, and acyl phosphates YP_500396.1 conserved hypothetical protein YP_500397.1 conserved hypothetical protein YP_500398.1 conserved hypothetical protein YP_500399.1 conserved hypothetical protein YP_500400.1 conserved hypothetical protein YP_500401.1 conserved hypothetical protein YP_500402.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_500403.1 conserved hypothetical protein YP_500404.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_500405.1 conserved hypothetical protein YP_500408.1 conserved hypothetical protein YP_500409.1 conserved hypothetical protein YP_500410.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_500411.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_500412.1 transposase, IS200 family YP_500413.1 conserved hypothetical protein YP_500414.1 conserved hypothetical protein YP_500415.1 conserved hypothetical protein YP_500416.1 conserved hypothetical protein YP_500417.1 o-succinylbenzoic acid--coa ligase, putative YP_500418.1 conserved hypothetical protein YP_500419.1 conserved hypothetical protein YP_500420.1 conserved hypothetical protein YP_500421.1 conserved hypothetical protein YP_500422.1 conserved hypothetical protein YP_500423.1 conserved hypothetical protein YP_500424.1 conserved hypothetical protein YP_500425.1 conserved hypothetical protein YP_500426.1 conserved hypothetical protein YP_500427.1 conserved hypothetical protein YP_500429.1 transposase family protein, putative YP_500430.1 conserved hypothetical protein YP_500431.1 conserved hypothetical protein YP_500432.1 conserved hypothetical protein YP_500433.1 type I restriction-modification enzyme, S subunit, EcoA family, putative YP_500434.1 type I restriction-modification system, M subunit YP_500435.1 conserved hypothetical protein YP_500436.1 serine protease SplF, putative YP_500444.1 conserved hypothetical protein YP_500445.1 membrane protein, putative YP_500446.1 membrane protein, putative YP_500447.1 ABC transporter domain protein YP_500448.1 intracellular serine protease, putative YP_500449.1 flavoprotein, epiD, putative YP_500450.1 epidermin biosynthesis protein EpiC, authentic point mutation YP_500451.1 lantibiotic epidermin biosynthesis protein EpiB, putative YP_500452.1 Gallidermin superfamily epiA, putative YP_500453.1 Pathogenicity island SaPIn3 YP_500454.1 Pathogenicity island SaPIn3 YP_500455.1 conserved hypothetical protein YP_500456.1 conserved hypothetical protein YP_500457.1 conserved hypothetical protein YP_500459.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX YP_500460.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_500461.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_500462.1 conserved hypothetical protein YP_500463.1 conserved hypothetical protein YP_500464.1 conserved hypothetical protein YP_500465.1 ABC transporter, ATP-binding protein, putative YP_500466.1 conserved hypothetical protein YP_500467.1 conserved hypothetical protein YP_500468.1 conserved hypothetical protein YP_500469.1 protein export protein PrsA, putative YP_500470.1 catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates YP_500471.1 conserved hypothetical protein YP_500472.1 conserved hypothetical protein YP_500473.1 conserved hypothetical protein YP_500474.1 conserved hypothetical protein YP_500475.1 conserved hypothetical protein YP_500476.1 conserved hypothetical protein YP_500477.1 DNA-binding response regulator, putative YP_500478.1 sensor histidine kinase, putative YP_500479.1 ribosomal large subunit pseudouridine synthase, RluD subfamily, putative YP_500480.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_500481.1 conserved hypothetical protein YP_500482.1 conserved hypothetical protein YP_500483.1 conserved hypothetical protein YP_500484.1 conserved hypothetical protein YP_500485.1 conserved hypothetical protein YP_500486.1 conserved hypothetical protein YP_500487.1 amino acid ABC transporter, ATP-binding protein, putative YP_500488.1 ABC transporter, permease protein, putative YP_500489.1 Phosphotransferase system, EIIC domain protein YP_500494.1 ferric uptake regulator-like protein, putative YP_500495.1 conserved hypothetical protein YP_500496.1 conserved hypothetical protein YP_500497.2 converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate YP_500498.1 conserved hypothetical protein YP_500500.1 ABC transporter, ATP-binding/permease protein, putative YP_500501.1 conserved hypothetical protein YP_500502.1 A/G-specific adenine glycosylase, putative YP_500503.1 conserved hypothetical protein YP_500505.1 conserved hypothetical protein YP_500506.1 conserved hypothetical protein YP_500507.1 conserved hypothetical protein YP_500508.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_500509.1 monofunctional; catalyzes the elongation of glycan strands in cell wall biosynthesis YP_500510.1 conserved hypothetical protein YP_500511.1 conserved hypothetical protein YP_500512.1 hypothetical phage protein YP_500513.1 conserved hypothetical phage protein YP_500514.1 conserved hypothetical phage protein YP_500515.1 conserved hypothetical phage protein YP_500519.1 phage tail fiber protein, putative YP_500520.1 bifunctional autolysin precursor YP_500522.1 phi ETA orf 58-like protein-related protein YP_500527.1 conserved hypothetical phage protein YP_500529.1 conserved hypothetical phage protein YP_500530.1 conserved hypothetical phage protein YP_500531.1 phage structural protein, putative YP_500532.1 conserved hypothetical phage protein YP_500533.1 phage protein, HK97 gp10 family YP_500534.1 conserved hypothetical phage protein YP_500537.1 phage head protein, putative YP_500538.1 conserved hypothetical phage protein YP_500539.1 conserved hypothetical phage protein YP_500540.1 phage putative head morphogenesis protein, SPP1 gp7 family domain protein YP_500541.1 phage portal protein, SPP1 family YP_500542.1 phage terminase, large subunit, PBSX family YP_500543.1 terminase small subunit, putative YP_500545.1 hypothetical phage protein YP_500546.1 transcriptional activator rinb-related protein YP_500547.1 conserved hypothetical phage protein YP_500548.1 conserved hypothetical phage protein YP_500549.1 conserved hypothetical phage protein YP_500551.1 conserved hypothetical phage protein YP_500556.1 PV83 orf 23-like protein-related protein YP_500558.1 conserved hypothetical phage protein YP_500559.1 conserved hypothetical phage protein YP_500560.1 bacteriophage L54a, DnaB-like helicase family protein YP_500561.1 conserved hypothetical phage protein YP_500564.1 single-strand DNA-binding protein, putative YP_500565.1 conserved hypothetical phage protein YP_500566.1 conserved hypothetical phage protein YP_500569.1 phi PVL orf 38-like protein-related protein YP_500570.2 phi PV83 orf 12-like protein-related protein YP_500572.1 conserved hypothetical phage protein YP_500573.1 bacteriophage L54a, antirepressor, putative YP_500574.1 conserved hypothetical phage protein YP_500575.1 bacteriophage L54a, Cro-related protein YP_500576.1 phage repressor protein, putative YP_500577.1 conserved hypothetical phage protein YP_500578.1 PV83 orf 4-like protein-related protein YP_500579.1 conserved hypothetical phage protein YP_500580.1 excisionase-related protein YP_500581.1 integrase, phage family, putative YP_500582.1 conserved hypothetical phage protein YP_500583.1 conserved hypothetical protein YP_500584.1 aminopeptidase PepS, putative YP_500585.1 conserved hypothetical protein YP_500586.1 conserved hypothetical protein YP_500587.1 conserved hypothetical protein YP_500588.1 conserved hypothetical protein YP_500589.1 DNA-binding response regulator VraR, putative YP_500590.1 histidine kinase, putative YP_500591.1 conserved hypothetical protein YP_500592.1 conserved hypothetical protein YP_500593.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_500595.1 conserved hypothetical protein YP_500596.1 conserved hypothetical protein YP_500597.1 conserved hypothetical protein YP_500598.1 conserved hypothetical protein YP_500599.1 UDP-N-acetylmuramyl tripeptide synthetase, putative YP_500600.1 ferritin, putative YP_500601.1 conserved hypothetical protein YP_500602.1 conserved hypothetical protein YP_500603.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_500604.1 conserved hypothetical protein YP_500605.1 RNA methyltransferase, TrmA family, putative YP_500606.1 similar to YegS from E. coli YP_500607.1 conserved hypothetical protein YP_500608.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_500609.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_500610.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_500611.1 validated YP_500612.1 conserved hypothetical protein YP_500613.1 DNA ligase, NAD-dependent YP_500615.1 PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer YP_500616.1 conserved hypothetical protein YP_500617.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_500619.1 conserved hypothetical protein YP_500620.1 conserved hypothetical protein YP_500621.1 conserved hypothetical protein YP_500622.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_500623.2 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_500624.1 nitric oxide synthase, oxygenase domain, putative YP_500625.1 conserved hypothetical protein YP_500627.1 sodium-dependent transporter (huNaDC-1), putative YP_500628.1 conserved hypothetical protein YP_500629.1 pyrazinamidase/nicotinamidase, putative YP_500630.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_500631.1 conserved hypothetical protein YP_500632.1 aldehyde dehydrogenase, putative YP_500633.1 conserved hypothetical protein YP_500634.1 conserved hypothetical protein YP_500635.1 conserved hypothetical protein YP_500636.1 conserved hypothetical protein YP_500637.1 conserved hypothetical protein YP_500638.1 conserved hypothetical protein YP_500639.1 conserved hypothetical protein YP_500640.1 conserved hypothetical protein YP_500641.1 conserved hypothetical protein YP_500642.1 ABC transporter, ATP-binding protein, putative YP_500643.1 conserved hypothetical protein YP_500644.1 ABC transporter, ATP-binding protein, putative YP_500645.1 conserved hypothetical protein YP_500646.1 conserved hypothetical protein YP_500647.1 conserved hypothetical protein YP_500648.1 conserved hypothetical protein YP_500649.1 conserved hypothetical protein YP_500652.1 conserved hypothetical phage protein YP_500654.1 hypothetical phage protein YP_500655.1 conserved hypothetical phage protein YP_500656.1 secreted protein that specifically inhibits the activation of neutrophils and monocytes by binding to the formylated peptide receptor and the C5a receptor; blocks neutrophil migration towards the infection site and hinders the establishment of the initial defense against the infection YP_500657.1 peptidoglycan hydrolase, putative YP_500658.1 staphylokinase precursor, putative YP_500660.1 holin, phage phi LC3 family YP_500661.1 hypothetical phage protein YP_500662.1 conserved hypothetical phage protein YP_500663.1 conserved hypothetical phage protein YP_500665.1 conserved hypothetical phage protein YP_500666.1 phage minor structural protein, N-terminal region domain protein YP_500669.1 conserved hypothetical phage protein YP_500673.1 phage protein, HK97 gp10 family YP_500674.1 phage head-tail adaptor, putative YP_500675.1 conserved hypothetical phage protein YP_500676.1 conserved hypothetical phage protein YP_500677.1 phage major capsid protein, HK97 family YP_500679.1 phage portal protein, HK97 family YP_500680.1 phi PVL orf 3-like protein-related protein YP_500681.1 phage terminase, large subunit, putative YP_500682.1 phage terminase, small subunit, putative YP_500683.1 conserved hypothetical phage protein YP_500685.1 conserved hypothetical phage protein YP_500687.1 conserved hypothetical phage protein YP_500688.1 conserved hypothetical phage protein YP_500689.1 conserved hypothetical phage protein YP_500690.1 conserved hypothetical phage protein YP_500691.1 hypothetical phage protein YP_500694.1 conserved hypothetical phage protein YP_500697.1 conserved hypothetical phage protein YP_500699.1 conserved hypothetical phage protein YP_500700.1 conserved hypothetical phage protein YP_500703.1 conserved hypothetical phage protein YP_500706.1 conserved hypothetical phage protein YP_500707.1 conserved hypothetical phage protein YP_500709.1 phi PVL orf 38-like protein-related protein YP_500710.1 conserved hypothetical phage protein YP_500711.1 conserved hypothetical phage protein YP_500712.1 conserved hypothetical phage protein YP_500713.1 conserved hypothetical phage protein YP_500718.1 repressor-like protein-related protein YP_500720.1 conserved hypothetical phage protein YP_500721.1 hypothetical phage protein YP_500725.1 conserved hypothetical protein YP_500726.1 conserved hypothetical protein YP_500727.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_500728.1 conserved hypothetical protein YP_500729.1 conserved hypothetical protein YP_500730.1 cation transport protein, putative YP_500731.1 conserved hypothetical protein YP_500732.1 conserved hypothetical protein YP_500733.1 phage terminase, small subunit, putative YP_500734.1 conserved hypothetical protein YP_500736.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_500737.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_500738.1 abortive infection protein YP_500739.1 conserved hypothetical protein YP_500740.1 conserved hypothetical protein YP_500741.1 conserved hypothetical protein YP_500742.1 Lyses erythrocytes and other mammalian cells YP_500744.1 conserved hypothetical protein YP_500747.1 conserved hypothetical protein YP_500748.1 fructokinase, putative YP_500749.1 sucrose-6-phosphate dehydrogenase, putative YP_500750.1 sucrose operon repressor, putative YP_500752.1 conserved hypothetical protein YP_500753.1 conserved hypothetical protein YP_500754.1 modulates transcription in response to the NADH/NAD(+) redox state YP_500755.1 ABC transporter, ATP-binding protein, putative YP_500757.1 MutS domain V protein YP_500758.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_500760.1 conserved hypothetical protein YP_500761.1 conserved hypothetical protein YP_500763.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_500764.1 acetolactate synthase, large subunit, biosynthetic type YP_500765.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, this subunit subunit is required for full activity and valine sensitivity; also known as acetolactate synthase small YP_500766.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_500767.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_500768.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_500769.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_500770.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_500771.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_500774.1 conserved hypothetical protein YP_500775.1 S1 RNA binding domain protein YP_500776.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase YP_500777.1 binds to sigma-B preventing the formation of an RNA polymerase holoenzyme YP_500778.1 STAS domain, putative YP_500782.1 conserved hypothetical protein YP_500783.1 conserved hypothetical protein YP_500785.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_500786.1 conserved hypothetical protein YP_500787.1 conserved hypothetical protein YP_500788.1 conserved hypothetical protein YP_500789.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex YP_500790.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_500791.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_500793.1 sensor protein KdpD, putative YP_500794.1 DNA-binding response regulator, putative YP_500795.1 ATP-dependent RNA helicase, DEAD box family, putative YP_500797.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_500798.1 conserved hypothetical protein YP_500799.1 conserved hypothetical protein YP_500800.1 conserved hypothetical protein YP_500801.1 conserved hypothetical protein YP_500802.1 cardiolipin synthetase, putative YP_500803.1 conserved hypothetical protein YP_500805.1 conserved hypothetical protein YP_500806.1 conserved hypothetical protein YP_500807.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_500808.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_500809.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_500810.1 conserved hypothetical protein YP_500811.1 conserved hypothetical protein YP_500812.1 sceD protein, putative YP_500813.1 bacteriophage L54a, single-stranded DNA binding protein YP_500814.1 conserved hypothetical protein YP_500815.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_500816.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_500817.1 conserved hypothetical protein YP_500819.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_500820.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_500821.2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_500822.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_500823.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_500824.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel YP_500825.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_500826.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_500827.1 conserved hypothetical protein YP_500828.1 UDP-N-acetylglucosamine 2-epimerase YP_500829.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_500830.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_500831.1 conserved hypothetical protein YP_500832.1 conserved hypothetical protein YP_500833.1 conserved hypothetical protein YP_500834.1 modification methylase, HemK family, putative YP_500835.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_500836.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_500837.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_500838.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_500839.1 aldehyde dehydrogenase, putative YP_500840.1 conserved hypothetical protein YP_500841.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_500842.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; induced by anaerobic conditions in Bacillus subtilis YP_500843.1 conserved hypothetical protein YP_500844.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_500845.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling YP_500846.1 conserved hypothetical protein YP_500848.1 catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type II pantothenate kinases are not regulated by feedback inhibition by coenzyme A YP_500849.1 conserved hypothetical protein YP_500850.1 conserved hypothetical protein YP_500851.1 aminobenzoyl-glutamate utilization protein B, putative YP_500852.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_500853.1 conserved hypothetical protein YP_500854.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway YP_500856.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_500857.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_500858.1 conserved hypothetical protein YP_500859.1 conserved hypothetical protein YP_500860.1 conserved hypothetical protein YP_500861.1 conserved hypothetical protein YP_500862.1 mannose-6-phosphate isomerase, class I YP_500863.1 conserved hypothetical protein YP_500864.1 conserved hypothetical protein YP_500865.1 conserved hypothetical protein YP_500866.1 cation efflux family protein, putative YP_500867.1 lytic regulatory protein, putative YP_500868.1 conserved hypothetical protein YP_500870.1 conserved hypothetical protein YP_500873.1 conserved hypothetical protein YP_500874.1 ABC transporter, ATP-binding protein, putative YP_500875.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_500876.1 PTS system, mannitol-specific component, putative YP_500877.1 conserved hypothetical protein YP_500878.1 PTS system, mannitol-specific IIa component, putative YP_500879.1 mannitol-1-phosphate 5-dehydrogenase, putative YP_500880.1 conserved hypothetical protein YP_500881.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_500882.1 conserved hypothetical protein YP_500883.1 conserved hypothetical protein YP_500890.1 conserved hypothetical protein YP_500891.1 conserved hypothetical protein YP_500892.1 conserved hypothetical protein YP_500893.1 conserved hypothetical protein YP_500894.1 UDP-N-acetylglucosamine pyrophosphorylase, putative YP_500895.1 conserved hypothetical protein YP_500896.1 conserved hypothetical protein YP_500897.1 membrane protein, putative YP_500898.1 conserved hypothetical protein YP_500899.1 conserved hypothetical protein YP_500900.1 ABC transporter periplasmic binding protein, putative YP_500902.1 conserved hypothetical protein YP_500903.1 conserved hypothetical protein YP_500904.1 conserved hypothetical protein YP_500905.1 conserved hypothetical protein YP_500909.1 conserved hypothetical protein YP_500910.1 conserved hypothetical protein YP_500911.1 conserved hypothetical protein YP_500912.1 osmoprotectant transporter, BCCT family, opuD-like protein, putative YP_500913.1 conserved hypothetical protein YP_500914.1 conserved hypothetical protein YP_500915.1 conserved hypothetical protein YP_500916.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside YP_500917.1 pts system, lactose-specific IIBC component, putative YP_500918.1 PTS system lactose-specific IIA component, putative YP_500919.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources YP_500920.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP YP_500921.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate YP_500922.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization YP_500923.1 lactose phosphotransferase system repressor, putative YP_500924.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_500925.1 conserved hypothetical protein YP_500926.1 conserved hypothetical protein YP_500927.1 conserved hypothetical protein YP_500928.1 conserved hypothetical protein YP_500929.1 transcriptional regulator, merR family, putative YP_500932.1 conserved hypothetical protein YP_500933.1 conserved hypothetical protein YP_500936.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_500937.1 conserved hypothetical protein YP_500938.1 conserved hypothetical protein YP_500939.1 conserved hypothetical protein YP_500940.1 conserved hypothetical protein YP_500942.1 conserved hypothetical protein YP_500943.1 conserved hypothetical protein YP_500944.1 conserved hypothetical protein YP_500946.1 forms a direct contact with the tRNA during translation YP_500947.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_500948.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_500949.1 cobalt transport protein, putative YP_500950.1 with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene YP_500951.1 with CbiNQ forms the ABC transporter for cobalt import; Staphylococcus has two adjacent copies of this gene YP_500952.1 is a component of the macrolide binding site in the peptidyl transferase center YP_500953.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_500954.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_500955.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_500956.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_500957.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_500958.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_500959.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_500960.1 late assembly protein YP_500961.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_500962.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_500963.1 binds 5S rRNA along with protein L5 and L25 YP_500964.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_500965.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_500966.2 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_500967.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_500968.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_500969.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_500970.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_500971.1 one of the stabilizing components for the large ribosomal subunit YP_500972.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_500973.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_500974.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_500975.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_500976.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_500977.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_500978.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_500979.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_500980.1 conserved hypothetical protein YP_500981.1 conserved hypothetical protein YP_500982.1 decatenates replicating daughter chromosomes YP_500983.1 conserved hypothetical protein YP_500984.1 conserved hypothetical protein YP_500985.1 sugar transporter, putative YP_500986.1 conserved hypothetical protein YP_500987.1 conserved hypothetical protein YP_500988.1 conserved hypothetical protein YP_500989.1 conserved hypothetical protein YP_500990.1 conserved hypothetical protein YP_500991.1 FmhB protein, putative YP_500992.1 conserved hypothetical protein YP_500993.1 conserved hypothetical protein YP_500994.1 conserved hypothetical protein YP_500995.1 conserved hypothetical protein YP_500996.1 conserved hypothetical protein YP_500997.1 conserved hypothetical protein YP_500998.1 conserved hypothetical protein YP_500999.1 conserved hypothetical protein YP_501000.1 molybdopterin cofactor biosynthesis protein A, putative YP_501001.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_501002.1 molybdopterin converting factor, subunit 1 YP_501003.1 molybdopterin converting factor moa, putative YP_501005.1 molybdopterin biosynthesis protein moeA, putative YP_501006.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_501007.1 molybdopterin precursor biosynthesis moaB, putative YP_501008.1 conserved hypothetical protein YP_501009.1 molybdenum transport ATP-binding protein ModC, putative YP_501010.1 molybdenum ABC transporter, permease protein, putative YP_501011.1 molybdenum ABC transporter, periplasmic molybdate-binding protein YP_501012.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_501013.1 conserved hypothetical protein YP_501014.1 conserved hypothetical protein YP_501015.1 conserved hypothetical protein YP_501016.1 conserved hypothetical protein YP_501019.1 urea transporter, putative YP_501020.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_501021.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Staphylococcus saprophyticus plays a role in bladder invasiveness and may induce the formation of kidney and bladder stones due to the alkalization of urine YP_501022.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_501023.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_501024.1 urease accessory protein UreF, putative YP_501026.1 urease accessory protein UreD, putative YP_501027.1 conserved hypothetical protein YP_501029.1 conserved hypothetical protein YP_501030.1 conserved hypothetical protein YP_501031.1 conserved hypothetical protein YP_501032.1 secretory antigen precursor, putative YP_501033.1 conserved hypothetical protein YP_501035.1 conserved hypothetical protein YP_501036.1 conserved hypothetical protein YP_501037.1 secretory antigen precursor SsaA, putative YP_501039.1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein YP_501040.1 conserved hypothetical protein YP_501041.1 N-acetylmuramoyl-L-alanine amidase, putative YP_501042.1 conserved hypothetical protein YP_501043.1 conserved hypothetical protein YP_501044.1 formate dehydrogenase, alpha subunit, putative YP_501045.1 transcriptional regulator, putative YP_501046.1 conserved hypothetical protein YP_501047.1 conserved hypothetical protein YP_501049.1 conserved hypothetical protein YP_501050.2 conserved hypothetical protein YP_501051.1 conserved hypothetical protein YP_501052.1 conserved hypothetical protein YP_501053.1 conserved hypothetical protein YP_501054.1 conserved hypothetical protein YP_501055.1 conserved hypothetical protein YP_501056.1 conserved hypothetical protein YP_501057.1 conserved hypothetical protein YP_501058.1 conserved hypothetical protein YP_501059.1 PTS system component, putative YP_501060.1 Hex regulon repressor, putative YP_501061.1 conserved hypothetical protein YP_501064.1 conserved hypothetical protein YP_501065.1 conserved hypothetical protein YP_501066.1 conserved hypothetical protein YP_501067.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_501068.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_501069.1 conserved hypothetical protein YP_501070.1 catalyzes resistance to fosfomycin by the addition of a thiol cofactor YP_501071.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_501072.1 conserved hypothetical protein YP_501073.1 catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_501074.1 conserved hypothetical protein YP_501076.1 aldose 1-epimerase precursor, putative YP_501077.1 conserved hypothetical protein YP_501079.1 conserved hypothetical protein YP_501080.1 conserved hypothetical protein YP_501081.1 conserved hypothetical protein YP_501082.1 DNA-3-methyladenine glycosylase, putative YP_501084.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_501085.1 conserved hypothetical protein YP_501086.1 conserved hypothetical protein YP_501087.1 conserved hypothetical protein YP_501088.1 conserved hypothetical protein YP_501089.1 conserved hypothetical protein YP_501090.1 drug resistance transporter, EmrB/QacA subfamily, putative YP_501091.1 conserved hypothetical protein YP_501092.1 conserved hypothetical protein YP_501095.1 conserved hypothetical protein YP_501096.1 conserved hypothetical protein YP_501100.1 conserved hypothetical protein YP_501103.1 conserved hypothetical protein YP_501104.1 permease, putative domain protein YP_501105.1 DNA-binding response regulator, putative YP_501106.1 sensor histidine kinase, putative YP_501107.1 conserved hypothetical protein YP_501108.1 conserved hypothetical protein YP_501109.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_501111.1 conserved hypothetical protein YP_501112.1 lipoprotein, putative YP_501113.1 conserved hypothetical protein YP_501114.1 conserved hypothetical protein YP_501115.1 conserved hypothetical protein YP_501116.1 conserved hypothetical protein YP_501117.1 conserved hypothetical protein YP_501118.1 conserved hypothetical protein YP_501119.1 conserved hypothetical protein YP_501120.1 membrane protein, putative YP_501121.1 conserved hypothetical protein YP_501122.1 conserved hypothetical protein YP_501123.1 PTS system sucrose-specific IIBC component, putative YP_501124.1 PTS system sucrose-specific IIBC component YP_501125.2 conserved hypothetical protein YP_501126.1 transcriptional regulator, putative YP_501127.1 conserved hypothetical protein YP_501128.1 conserved hypothetical protein YP_501129.1 conserved hypothetical protein YP_501130.1 conserved hypothetical protein YP_501131.1 conserved hypothetical protein YP_501132.1 conserved hypothetical protein YP_501133.1 conserved hypothetical protein YP_501136.1 conserved hypothetical protein YP_501137.1 conserved hypothetical protein YP_501138.1 conserved hypothetical protein YP_501139.1 conserved hypothetical protein YP_501140.1 respiratory nitrate reductase, gamma subunit YP_501141.1 respiratory nitrate reductase, delta subunit, putative YP_501142.1 nitrate reductase, beta subunit YP_501143.1 nitrate reductase, alpha subunit YP_501144.1 uroporphyrin-III C-methyltransferase, putative YP_501145.1 assimilatory nitrite reductase [NAD(P)H], small subunit, putative YP_501146.1 assimilatory nitrite reductase [NAD(P)H], large subunit, putative YP_501147.1 conserved hypothetical protein YP_501148.1 conserved hypothetical protein YP_501149.1 formate/nitrite transporter, putative YP_501150.1 conserved hypothetical protein YP_501151.1 conserved hypothetical protein YP_501152.1 conserved hypothetical protein YP_501153.1 conserved hypothetical protein YP_501154.1 conserved hypothetical protein YP_501155.1 conserved hypothetical protein YP_501156.1 conserved hypothetical protein YP_501157.1 conserved hypothetical protein YP_501158.1 fmhA protein, putative YP_501159.1 amino acid ABC transporter, ATP-binding protein, putative YP_501160.1 amino acid ABC transproter, permease protein, putative YP_501161.1 conserved hypothetical protein YP_501162.1 conserved hypothetical protein YP_501164.1 conserved hypothetical protein YP_501165.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_501166.1 conserved hypothetical protein YP_501167.1 conserved hypothetical protein YP_501168.1 immunoglobulin G-binding protein Sbi, putative YP_501170.1 gamma-hemolysin h-gamma-ii subunit, putative YP_501171.1 leukocidin s subunit precursor, putative YP_501172.1 leukocidin f subunit precursor YP_501173.1 conserved hypothetical protein YP_501174.1 catalyzes the formation of pimeloyl-CoA from pimelate and coenzyme A YP_501175.1 conserved hypothetical protein YP_501176.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine YP_501178.1 dethiobiotin synthase, putative YP_501180.1 conserved hypothetical protein YP_501181.1 conserved hypothetical protein YP_501182.1 conserved hypothetical protein YP_501183.1 conserved hypothetical protein YP_501184.1 conserved hypothetical protein YP_501185.1 conserved hypothetical protein YP_501186.1 glycerate kinase, putative YP_501187.1 conserved hypothetical protein YP_501188.1 conserved hypothetical protein YP_501189.1 positive transcriptional activator, putative YP_501190.1 conserved hypothetical protein YP_501191.1 conserved hypothetical protein YP_501192.1 amino acid ABC transporter-like protein, putative YP_501193.1 conserved hypothetical protein YP_501195.1 membrane protein, putative YP_501196.1 conserved hypothetical protein YP_501197.1 conserved hypothetical protein YP_501198.1 epimerase/dehydratase, putative YP_501200.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_501201.1 drug transporter, putative YP_501202.1 amino acid ABC transporter, permease protein, putative YP_501203.1 amino acid transporter, putative YP_501204.1 amino acid ABC transporter, permease protein, putative YP_501205.1 amino acid ABC transporter, ATP-binding protein, putative YP_501206.1 conserved hypothetical protein YP_501207.1 conserved hypothetical protein YP_501208.1 conserved hypothetical protein YP_501209.1 conserved hypothetical protein YP_501210.1 conserved hypothetical protein YP_501211.1 conserved hypothetical protein YP_501212.1 membrane protein, putative YP_501213.1 ABC transporter, ATP-binding protein, putative YP_501214.1 conserved hypothetical protein YP_501215.1 conserved hypothetical protein YP_501216.1 conserved hypothetical protein YP_501218.1 conserved hypothetical protein YP_501219.1 glutamate synthase alpha subunit, putative YP_501220.1 conserved hypothetical protein YP_501221.1 conserved hypothetical protein YP_501222.1 peptide ABC transporter, ATP-binding protein, putative YP_501223.1 peptide ABC transporter, ATP-binding protein, putative YP_501224.1 nickel ABC transporter, permease protein, putative YP_501225.1 peptide ABC transporter, permease protein, putative YP_501226.1 peptide ABC transporter, peptide-binding protein, putative YP_501227.1 conserved hypothetical protein YP_501228.1 conserved hypothetical protein YP_501229.1 conserved hypothetical protein YP_501230.1 conserved hypothetical protein YP_501231.2 conserved hypothetical protein YP_501232.1 transporter, putative YP_501233.1 conserved hypothetical protein YP_501234.1 conserved hypothetical protein YP_501235.1 conserved hypothetical protein YP_501237.1 conserved hypothetical protein YP_501238.1 conserved hypothetical protein YP_501239.1 conserved hypothetical protein YP_501240.1 conserved hypothetical protein YP_501241.1 conserved hypothetical protein YP_501242.1 conserved hypothetical protein YP_501243.1 conserved hypothetical protein YP_501244.1 conserved hypothetical protein YP_501245.1 conserved hypothetical protein YP_501248.1 conserved hypothetical protein YP_501249.1 conserved hypothetical protein YP_501250.1 conserved hypothetical protein YP_501251.1 pyrophosphohydrolase, putative YP_501252.1 conserved hypothetical protein YP_501253.1 conserved hypothetical protein YP_501254.1 conserved hypothetical protein YP_501255.1 conserved hypothetical protein YP_501256.1 conserved hypothetical protein YP_501257.1 conserved hypothetical protein YP_501258.1 staphylococcal accessory regulator T, putative YP_501259.1 conserved hypothetical protein YP_501261.1 fibronectin binding protein B, putative YP_501262.1 fibronectin-binding protein precursor, putative YP_501263.1 conserved hypothetical protein YP_501264.1 conserved hypothetical protein YP_501265.1 gluconate permease, putative YP_501267.1 gluconate operon transcriptional repressor, putative YP_501268.1 conserved hypothetical protein YP_501269.1 conserved hypothetical protein YP_501270.1 conserved hypothetical protein YP_501273.1 conserved hypothetical protein YP_501274.1 conserved hypothetical protein YP_501276.1 conserved hypothetical protein YP_501277.1 conserved hypothetical protein YP_501278.1 conserved hypothetical protein YP_501279.1 membrane spanning protein, putative YP_501280.1 conserved hypothetical protein YP_501282.1 conserved hypothetical protein YP_501283.1 conserved hypothetical protein YP_501284.1 conserved hypothetical protein YP_501285.1 conserved hypothetical protein YP_501286.1 conserved hypothetical protein YP_501287.1 conserved hypothetical protein YP_501288.1 NAD(P)H-flavin oxidoreductase, putative YP_501289.1 catalyzes the formation of pyruvate from lactate YP_501290.1 conserved hypothetical protein YP_501291.1 conserved hypothetical protein YP_501292.1 conserved hypothetical protein YP_501293.1 sortase, putative YP_501294.1 conserved hypothetical protein YP_501295.1 conserved hypothetical protein YP_501296.1 conserved hypothetical protein YP_501297.1 L-serine dehydratase, iron-sulfur-dependent, alpha subunit YP_501298.1 L-serine dehydratase, iron-sulfur-dependent, beta subunit YP_501299.1 conserved hypothetical protein YP_501300.1 conserved hypothetical protein YP_501301.1 conserved hypothetical protein YP_501302.1 conserved hypothetical protein YP_501303.1 conserved hypothetical protein YP_501304.1 conserved hypothetical protein YP_501305.1 PTS system glucose-specific IIABC component YP_501306.1 catalyzes the formation of acetyl phosphate from pyruvate YP_501307.1 conserved hypothetical protein YP_501308.1 conserved hypothetical protein YP_501309.1 conserved hypothetical protein YP_501310.1 conserved hypothetical protein YP_501311.1 LysM domain protein YP_501313.1 conserved hypothetical protein YP_501314.1 conserved hypothetical protein YP_501315.1 hydroxymethylglutaryl-CoA reductase, degradative YP_501316.1 HMG-CoA synthase, putative YP_501317.1 methylated-DNA--protein-cysteine methyltransferase, putative YP_501318.1 ATP-dependent Clp protease, ATP-binding subunit ClpC, putative YP_501319.1 conserved hypothetical protein YP_501321.1 conserved hypothetical protein YP_501322.1 conserved hypothetical protein YP_501323.1 conserved hypothetical protein YP_501324.1 conserved hypothetical protein YP_501325.1 catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate YP_501326.1 conserved hypothetical protein YP_501327.1 conserved hypothetical protein YP_501328.1 cation-transporting ATPase, E1-E2 family, putative YP_501329.1 cation-transporting ATPase, E1-E2 family, putative YP_501330.1 catalyzes the formation of pyruvate from lactate YP_501331.1 conserved hypothetical protein YP_501332.1 squalene synthase, putative YP_501333.1 squalene desaturase, putative YP_501334.1 conserved hypothetical protein YP_501335.1 conserved hypothetical protein YP_501336.1 conserved hypothetical protein YP_501337.1 LysM domain protein YP_501338.1 conserved hypothetical protein YP_501339.1 conserved hypothetical protein YP_501340.1 immunodominant antigen A, putative YP_501341.1 conserved hypothetical protein YP_501343.1 conserved hypothetical protein YP_501344.1 conserved hypothetical protein YP_501345.1 conserved hypothetical protein YP_501346.1 conserved hypothetical protein YP_501347.1 conserved hypothetical protein YP_501348.1 conserved hypothetical protein YP_501349.1 conserved hypothetical protein YP_501350.1 conserved hypothetical protein YP_501351.1 conserved hypothetical protein YP_501352.1 conserved hypothetical protein YP_501353.1 conserved hypothetical protein YP_501354.1 conserved hypothetical protein YP_501357.1 conserved hypothetical protein YP_501358.1 conserved hypothetical protein YP_501359.1 conserved hypothetical protein YP_501360.1 conserved hypothetical protein YP_501361.1 conserved hypothetical protein YP_501362.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_501363.1 conserved hypothetical protein YP_501364.1 conserved hypothetical protein YP_501365.1 conserved hypothetical protein YP_501366.1 conserved hypothetical protein YP_501367.1 conserved hypothetical protein YP_501368.1 conserved hypothetical protein YP_501369.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_501370.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_501371.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_501376.1 conserved hypothetical protein YP_501377.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_501378.1 conserved hypothetical protein YP_501379.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis YP_501380.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_501381.1 conserved hypothetical protein YP_501382.1 acetyl-CoA synthetase, putative YP_501383.1 conserved hypothetical protein YP_501384.1 conserved hypothetical protein YP_501385.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_501387.1 conserved hypothetical protein YP_501388.1 conserved hypothetical protein YP_501389.1 conserved hypothetical protein YP_501390.2 choline transporter, putative YP_501392.1 conserved hypothetical protein YP_501393.1 conserved hypothetical protein YP_501394.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_501395.1 citrate transporter, putative YP_501396.1 conserved hypothetical protein YP_501397.1 catalyzes the formation of siroheme from precorrin-2 YP_501398.1 sulfite reductase (NADPH) flavoprotein alpha-component, putative YP_501400.1 conserved hypothetical protein YP_501404.1 permease, putative domain protein YP_501405.1 ABC transporter, ATP-binding protein, putative YP_501406.1 sensor histidine kinase, putative YP_501407.1 DNA-binding response regulator, putative YP_501408.1 conserved hypothetical protein YP_501410.1 alkaline phosphatase III precursor, putative YP_501412.1 conserved hypothetical protein YP_501413.1 tributyrin esterase, putative YP_501414.1 clumping factor B, putative YP_501415.1 conserved hypothetical protein YP_501416.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_501417.1 arginine/ornithine antiporter, putative YP_501418.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_501419.1 catalyzes the degradation of arginine to citruline and ammonia YP_501421.1 conserved hypothetical protein YP_501422.1 aureolysin, putative YP_501423.1 conserved hypothetical protein YP_501424.1 conserved hypothetical protein YP_501425.1 conserved hypothetical protein YP_501426.1 PTS system, fructose-specific IIABC component, putative YP_501427.1 mannose-6-phosphate isomerase, class I YP_501428.1 phage infection protein, putative YP_501429.1 conserved hypothetical protein YP_501430.1 conserved hypothetical protein YP_501431.1 conserved hypothetical protein YP_501432.1 conserved hypothetical protein YP_501433.1 conserved hypothetical protein YP_501434.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins YP_501435.1 conserved hypothetical protein YP_501436.1 conserved hypothetical protein YP_501437.1 conserved hypothetical protein YP_501438.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_501439.1 conserved hypothetical protein YP_501440.1 conserved hypothetical protein YP_501441.1 conserved hypothetical protein YP_501442.1 conserved hypothetical protein YP_501443.1 conserved hypothetical protein YP_501444.1 conserved hypothetical protein YP_501445.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; a fusion protein of this enzyme with MsrB provides protection against oxidative stress in Neisseria gonorrhoeae YP_501446.1 conserved hypothetical protein YP_501447.1 capsular polysaccharide biosynthesis protein, Cap5C YP_501449.1 capsular polysaccharide biosynthesis, capA, putative YP_501450.1 ica operon transcriptional regulator IcaR, putative YP_501451.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_501452.1 conserved hypothetical protein YP_501453.1 icaB protein, putative YP_501454.1 intercellular adhesion protein C, putative YP_501457.1 imidazole glycerol phosphate synthase subunit hisF, putative YP_501458.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-hosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_501459.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_501460.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_501461.1 histidinol-phosphate aminotransferase, putative YP_501462.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_501463.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_501464.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_501465.1 conserved hypothetical protein YP_501466.1 conserved hypothetical protein YP_501467.1 conserved hypothetical protein YP_501468.1 ABC transporter, ATP-binding protein, putative YP_501469.1 conserved hypothetical protein YP_501470.1 conserved hypothetical protein YP_501471.1 conserved hypothetical protein YP_501472.1 Drp35 YP_501473.1 conserved hypothetical protein YP_501474.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline YP_501475.1 conserved hypothetical protein YP_501476.1 conserved hypothetical protein YP_501477.1 conserved hypothetical protein YP_501478.1 sodium, sulfate symporter, putative YP_501479.1 conserved hypothetical protein YP_501480.1 conserved hypothetical protein YP_501481.1 high affinity nickel transporter, putative YP_501482.1 conserved hypothetical protein YP_501483.1 conserved hypothetical protein YP_501484.1 ABC transporter, ATP-binding protein, putative YP_501485.1 permease, putative YP_501488.1 conserved hypothetical protein YP_501489.1 integrase/recombinase, core domain family YP_501491.1 cold shock protein, putative YP_501492.1 Helix-turn-helix domain protein YP_501493.1 conserved hypothetical protein YP_501494.1 conserved hypothetical protein YP_501495.1 conserved hypothetical protein YP_501496.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_501497.2 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_501498.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_501499.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_501500.1 in Escherichia coli transcription of this gene is enhanced by polyamines