-- dump date 20140620_073429 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1323661000001 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1323661000002 Replication protein; Region: Rep_1; cl02412 1323661000003 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1323661000004 Cadmium resistance transporter; Region: Cad; pfam03596 1323661000005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1323661000006 putative DNA binding site [nucleotide binding]; other site 1323661000007 putative Zn2+ binding site [ion binding]; other site 1323661000008 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1323661000009 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1323661000010 NADP binding site [chemical binding]; other site 1323661000011 dimer interface [polypeptide binding]; other site 1323661000012 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661000013 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1323661000014 beta-lactamase TEM; Provisional; Region: PRK15442 1323661000015 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1323661000016 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1323661000017 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1323661000018 Predicted transcriptional regulator [Transcription]; Region: COG3682 1323661000019 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1323661000020 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1323661000021 catalytic residues [active] 1323661000022 catalytic nucleophile [active] 1323661000023 Presynaptic Site I dimer interface [polypeptide binding]; other site 1323661000024 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1323661000025 Synaptic Flat tetramer interface [polypeptide binding]; other site 1323661000026 Synaptic Site I dimer interface [polypeptide binding]; other site 1323661000027 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1323661000028 DNA-binding interface [nucleotide binding]; DNA binding site 1323661000029 Helix-turn-helix domain; Region: HTH_28; pfam13518 1323661000030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1323661000031 Integrase core domain; Region: rve; pfam00665 1323661000032 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1323661000033 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1323661000034 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1323661000035 Presynaptic Site I dimer interface [polypeptide binding]; other site 1323661000036 catalytic residues [active] 1323661000037 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1323661000038 Synaptic Flat tetramer interface [polypeptide binding]; other site 1323661000039 Synaptic Site I dimer interface [polypeptide binding]; other site 1323661000040 DNA binding site [nucleotide binding] 1323661000041 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1323661000042 DNA-binding interface [nucleotide binding]; DNA binding site 1323661000043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1323661000044 dimerization interface [polypeptide binding]; other site 1323661000045 putative DNA binding site [nucleotide binding]; other site 1323661000046 putative Zn2+ binding site [ion binding]; other site 1323661000047 arsenical pump membrane protein; Provisional; Region: PRK15445 1323661000048 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1323661000049 transmembrane helices; other site 1323661000050 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1323661000051 active site 1323661000052 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 1323661000053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1323661000054 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1323661000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1323661000056 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1323661000057 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1323661000058 Walker A/P-loop; other site 1323661000059 ATP binding site [chemical binding]; other site 1323661000060 Q-loop/lid; other site 1323661000061 ABC transporter signature motif; other site 1323661000062 Walker B; other site 1323661000063 D-loop; other site 1323661000064 H-loop/switch region; other site 1323661000065 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1323661000066 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1323661000067 Autophagy protein Apg6; Region: APG6; pfam04111 1323661000068 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1323661000069 Initiator Replication protein; Region: Rep_3; pfam01051 1323661000070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661000071 non-specific DNA binding site [nucleotide binding]; other site 1323661000072 salt bridge; other site 1323661000073 sequence-specific DNA binding site [nucleotide binding]; other site 1323661000074 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1323661000075 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1323661000076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661000077 Walker A motif; other site 1323661000078 ATP binding site [chemical binding]; other site 1323661000079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1323661000080 Walker B motif; other site 1323661000081 arginine finger; other site 1323661000082 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1323661000083 DnaA box-binding interface [nucleotide binding]; other site 1323661000084 DNA polymerase III subunit beta; Validated; Region: PRK05643 1323661000085 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1323661000086 putative DNA binding surface [nucleotide binding]; other site 1323661000087 dimer interface [polypeptide binding]; other site 1323661000088 beta-clamp/clamp loader binding surface; other site 1323661000089 beta-clamp/translesion DNA polymerase binding surface; other site 1323661000090 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1323661000091 recF protein; Region: recf; TIGR00611 1323661000092 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1323661000093 Walker A/P-loop; other site 1323661000094 ATP binding site [chemical binding]; other site 1323661000095 Q-loop/lid; other site 1323661000096 ABC transporter signature motif; other site 1323661000097 Walker B; other site 1323661000098 D-loop; other site 1323661000099 H-loop/switch region; other site 1323661000100 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1323661000101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661000102 Mg2+ binding site [ion binding]; other site 1323661000103 G-X-G motif; other site 1323661000104 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1323661000105 anchoring element; other site 1323661000106 dimer interface [polypeptide binding]; other site 1323661000107 ATP binding site [chemical binding]; other site 1323661000108 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1323661000109 active site 1323661000110 putative metal-binding site [ion binding]; other site 1323661000111 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1323661000112 DNA gyrase subunit A; Validated; Region: PRK05560 1323661000113 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1323661000114 CAP-like domain; other site 1323661000115 active site 1323661000116 primary dimer interface [polypeptide binding]; other site 1323661000117 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1323661000118 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1323661000119 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1323661000120 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1323661000121 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1323661000122 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1323661000123 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1323661000124 putative substrate binding site [chemical binding]; other site 1323661000125 putative ATP binding site [chemical binding]; other site 1323661000126 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 1323661000127 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1323661000128 active sites [active] 1323661000129 tetramer interface [polypeptide binding]; other site 1323661000130 seryl-tRNA synthetase; Provisional; Region: PRK05431 1323661000131 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1323661000132 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1323661000133 dimer interface [polypeptide binding]; other site 1323661000134 active site 1323661000135 motif 1; other site 1323661000136 motif 2; other site 1323661000137 motif 3; other site 1323661000138 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1323661000139 Predicted membrane protein [Function unknown]; Region: COG4392 1323661000140 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1323661000141 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1323661000142 Predicted membrane protein [Function unknown]; Region: COG4241 1323661000143 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1323661000144 Protein of unknown function (DUF996); Region: DUF996; cl00970 1323661000145 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1323661000146 DHH family; Region: DHH; pfam01368 1323661000147 DHHA1 domain; Region: DHHA1; pfam02272 1323661000148 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1323661000149 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1323661000150 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1323661000151 replicative DNA helicase; Region: DnaB; TIGR00665 1323661000152 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1323661000153 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1323661000154 Walker A motif; other site 1323661000155 ATP binding site [chemical binding]; other site 1323661000156 Walker B motif; other site 1323661000157 DNA binding loops [nucleotide binding] 1323661000158 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1323661000159 GDP-binding site [chemical binding]; other site 1323661000160 ACT binding site; other site 1323661000161 IMP binding site; other site 1323661000162 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661000163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661000164 active site 1323661000165 phosphorylation site [posttranslational modification] 1323661000166 intermolecular recognition site; other site 1323661000167 dimerization interface [polypeptide binding]; other site 1323661000168 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661000169 DNA binding site [nucleotide binding] 1323661000170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1323661000171 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1323661000172 dimerization interface [polypeptide binding]; other site 1323661000173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1323661000174 putative active site [active] 1323661000175 heme pocket [chemical binding]; other site 1323661000176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1323661000177 dimer interface [polypeptide binding]; other site 1323661000178 phosphorylation site [posttranslational modification] 1323661000179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661000180 ATP binding site [chemical binding]; other site 1323661000181 Mg2+ binding site [ion binding]; other site 1323661000182 G-X-G motif; other site 1323661000183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1323661000184 YycH protein; Region: YycH; pfam07435 1323661000185 YycH protein; Region: YycI; cl02015 1323661000186 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1323661000187 BDLF3; Provisional; Region: PHA03255 1323661000188 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1323661000189 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1323661000190 putative active site [active] 1323661000191 putative metal binding site [ion binding]; other site 1323661000192 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1323661000193 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1323661000194 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1323661000195 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1323661000196 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1323661000197 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 1323661000198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1323661000199 Integrase core domain; Region: rve; pfam00665 1323661000200 Replication protein; Region: Rep_1; cl02412 1323661000201 Replication protein; Region: Rep_1; pfam01446 1323661000202 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1323661000203 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1323661000204 dimer interface [polypeptide binding]; other site 1323661000205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1323661000206 ligand binding site [chemical binding]; other site 1323661000207 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cd05397 1323661000208 metal binding triad [ion binding]; metal-binding site 1323661000209 KNTase C-terminal domain; Region: KNTase_C; pfam07827 1323661000210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1323661000211 Integrase core domain; Region: rve; pfam00665 1323661000212 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1323661000213 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1323661000214 putative active site [active] 1323661000215 catalytic site [active] 1323661000216 putative metal binding site [ion binding]; other site 1323661000217 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1323661000218 putative active site [active] 1323661000219 putative catalytic site [active] 1323661000220 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1323661000221 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1323661000222 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1323661000223 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1323661000224 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1323661000225 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1323661000226 Predicted transcriptional regulator [Transcription]; Region: COG3682 1323661000227 MarR family; Region: MarR_2; pfam12802 1323661000228 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1323661000229 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1323661000230 nucleotide binding site [chemical binding]; other site 1323661000231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1323661000232 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1323661000233 active site residue [active] 1323661000234 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1323661000235 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1323661000236 active site residue [active] 1323661000237 SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that...; Region: SirA_RHOD_Pry_redox; cd03420 1323661000238 CPxP motif; other site 1323661000239 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1323661000240 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1323661000241 putative homodimer interface [polypeptide binding]; other site 1323661000242 putative homotetramer interface [polypeptide binding]; other site 1323661000243 putative metal binding site [ion binding]; other site 1323661000244 putative homodimer-homodimer interface [polypeptide binding]; other site 1323661000245 putative allosteric switch controlling residues; other site 1323661000246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661000247 S-adenosylmethionine binding site [chemical binding]; other site 1323661000248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661000249 S-adenosylmethionine binding site [chemical binding]; other site 1323661000250 aminoglycoside resistance protein; Provisional; Region: PRK13746 1323661000251 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1323661000252 active site 1323661000253 NTP binding site [chemical binding]; other site 1323661000254 metal binding triad [ion binding]; metal-binding site 1323661000255 antibiotic binding site [chemical binding]; other site 1323661000256 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1323661000257 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1323661000258 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1323661000259 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 1323661000260 Int/Topo IB signature motif; other site 1323661000261 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 1323661000262 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1323661000263 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 1323661000264 Int/Topo IB signature motif; other site 1323661000265 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 1323661000266 RadC-like JAB domain; Region: RadC; pfam04002 1323661000267 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1323661000268 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1323661000269 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 1323661000270 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1323661000271 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1323661000272 catalytic residues [active] 1323661000273 catalytic nucleophile [active] 1323661000274 Presynaptic Site I dimer interface [polypeptide binding]; other site 1323661000275 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1323661000276 Synaptic Flat tetramer interface [polypeptide binding]; other site 1323661000277 Synaptic Site I dimer interface [polypeptide binding]; other site 1323661000278 DNA binding site [nucleotide binding] 1323661000279 Recombinase; Region: Recombinase; pfam07508 1323661000280 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1323661000281 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1323661000282 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1323661000283 catalytic residues [active] 1323661000284 catalytic nucleophile [active] 1323661000285 Recombinase; Region: Recombinase; pfam07508 1323661000286 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1323661000287 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1323661000288 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1323661000289 Integrase core domain; Region: rve; pfam00665 1323661000290 Integrase core domain; Region: rve_3; cl15866 1323661000291 HTH-like domain; Region: HTH_21; pfam13276 1323661000292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1323661000293 Homeodomain-like domain; Region: HTH_23; cl17451 1323661000294 Predicted membrane protein [Function unknown]; Region: COG1288 1323661000295 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661000296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661000297 active site 1323661000298 phosphorylation site [posttranslational modification] 1323661000299 intermolecular recognition site; other site 1323661000300 dimerization interface [polypeptide binding]; other site 1323661000301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661000302 DNA binding site [nucleotide binding] 1323661000303 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1323661000304 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1323661000305 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1323661000306 Ligand Binding Site [chemical binding]; other site 1323661000307 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1323661000308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1323661000309 dimer interface [polypeptide binding]; other site 1323661000310 phosphorylation site [posttranslational modification] 1323661000311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661000312 ATP binding site [chemical binding]; other site 1323661000313 Mg2+ binding site [ion binding]; other site 1323661000314 G-X-G motif; other site 1323661000315 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1323661000316 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1323661000317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1323661000318 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1323661000319 potassium-transporting ATPase subunit C; Provisional; Region: PRK14000 1323661000320 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1323661000321 Protein kinase domain; Region: Pkinase; pfam00069 1323661000322 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1323661000323 active site 1323661000324 ATP binding site [chemical binding]; other site 1323661000325 substrate binding site [chemical binding]; other site 1323661000326 activation loop (A-loop); other site 1323661000327 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 1323661000328 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1323661000329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661000330 S-adenosylmethionine binding site [chemical binding]; other site 1323661000331 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1323661000332 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 1323661000333 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 1323661000334 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1323661000335 Integrase core domain; Region: rve_3; pfam13683 1323661000336 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1323661000337 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1323661000338 putative DNA binding site [nucleotide binding]; other site 1323661000339 putative Zn2+ binding site [ion binding]; other site 1323661000340 AsnC family; Region: AsnC_trans_reg; pfam01037 1323661000341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661000342 Coenzyme A binding pocket [chemical binding]; other site 1323661000343 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1323661000344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661000345 putative substrate translocation pore; other site 1323661000346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1323661000347 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 1323661000348 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1323661000349 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 1323661000350 FMN binding site [chemical binding]; other site 1323661000351 active site 1323661000352 catalytic residues [active] 1323661000353 substrate binding site [chemical binding]; other site 1323661000354 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1323661000355 hypothetical protein; Provisional; Region: PRK07206 1323661000356 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1323661000357 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1323661000358 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1323661000359 PYR/PP interface [polypeptide binding]; other site 1323661000360 dimer interface [polypeptide binding]; other site 1323661000361 TPP binding site [chemical binding]; other site 1323661000362 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1323661000363 TPP-binding site [chemical binding]; other site 1323661000364 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1323661000365 nucleotide binding site [chemical binding]; other site 1323661000366 substrate binding site [chemical binding]; other site 1323661000367 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 1323661000368 N-acetyl-ornithine/N-acetyl-lysine deacetylase; Region: dapE-lys-deAc; TIGR01902 1323661000369 metal binding site [ion binding]; metal-binding site 1323661000370 putative dimer interface [polypeptide binding]; other site 1323661000371 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1323661000372 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 1323661000373 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 1323661000374 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1323661000375 inhibitor-cofactor binding pocket; inhibition site 1323661000376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661000377 catalytic residue [active] 1323661000378 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 1323661000379 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1323661000380 Lysine biosynthesis protein LysW; Region: LysW; cd13946 1323661000381 Zn binding site [ion binding]; other site 1323661000382 ArgX binding interface [polypeptide binding]; other site 1323661000383 AAA attachment site [active] 1323661000384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661000385 non-specific DNA binding site [nucleotide binding]; other site 1323661000386 salt bridge; other site 1323661000387 sequence-specific DNA binding site [nucleotide binding]; other site 1323661000388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661000389 H+ Antiporter protein; Region: 2A0121; TIGR00900 1323661000390 putative substrate translocation pore; other site 1323661000391 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1323661000392 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1323661000393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1323661000394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1323661000395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1323661000396 dimerization interface [polypeptide binding]; other site 1323661000397 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1323661000398 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1323661000399 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1323661000400 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 1323661000401 hypothetical protein; Provisional; Region: PRK08317 1323661000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661000403 S-adenosylmethionine binding site [chemical binding]; other site 1323661000404 Domain of unknown function (DUF334); Region: DUF334; pfam03904 1323661000405 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1323661000406 active site 1323661000407 catalytic site [active] 1323661000408 putative metal binding site [ion binding]; other site 1323661000409 Protein of unknown function, DUF576; Region: DUF576; cl04553 1323661000410 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1323661000411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1323661000412 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1323661000413 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1323661000414 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1323661000415 metal binding site [ion binding]; metal-binding site 1323661000416 dimer interface [polypeptide binding]; other site 1323661000417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661000418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661000419 putative substrate translocation pore; other site 1323661000420 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1323661000421 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1323661000422 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1323661000423 PhoU domain; Region: PhoU; pfam01895 1323661000424 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1323661000425 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1323661000426 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1323661000427 EamA-like transporter family; Region: EamA; pfam00892 1323661000428 EamA-like transporter family; Region: EamA; pfam00892 1323661000429 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1323661000430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1323661000431 DNA-binding site [nucleotide binding]; DNA binding site 1323661000432 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1323661000433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661000434 homodimer interface [polypeptide binding]; other site 1323661000435 catalytic residue [active] 1323661000436 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1323661000437 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1323661000438 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661000439 B domain; Region: B; pfam02216 1323661000440 B domain; Region: B; pfam02216 1323661000441 B domain; Region: B; pfam02216 1323661000442 B domain; Region: B; pfam02216 1323661000443 B domain; Region: B; pfam02216 1323661000444 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1323661000445 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1323661000446 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661000447 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1323661000448 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661000449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661000450 ABC-ATPase subunit interface; other site 1323661000451 dimer interface [polypeptide binding]; other site 1323661000452 putative PBP binding regions; other site 1323661000453 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661000454 ABC-ATPase subunit interface; other site 1323661000455 dimer interface [polypeptide binding]; other site 1323661000456 putative PBP binding regions; other site 1323661000457 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1323661000458 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1323661000459 siderophore binding site; other site 1323661000460 cysteine synthase; Region: PLN02565 1323661000461 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1323661000462 dimer interface [polypeptide binding]; other site 1323661000463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661000464 catalytic residue [active] 1323661000465 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 1323661000466 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1323661000467 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1323661000468 IucA / IucC family; Region: IucA_IucC; pfam04183 1323661000469 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1323661000470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661000471 drug efflux system protein MdtG; Provisional; Region: PRK09874 1323661000472 putative substrate translocation pore; other site 1323661000473 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1323661000474 IucA / IucC family; Region: IucA_IucC; pfam04183 1323661000475 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1323661000476 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1323661000477 IucA / IucC family; Region: IucA_IucC; pfam04183 1323661000478 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1323661000479 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1323661000480 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1323661000481 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1323661000482 dimer interface [polypeptide binding]; other site 1323661000483 active site 1323661000484 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1323661000485 catalytic residues [active] 1323661000486 substrate binding site [chemical binding]; other site 1323661000487 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1323661000488 ParB-like nuclease domain; Region: ParBc; pfam02195 1323661000489 acetoin reductase; Validated; Region: PRK08643 1323661000490 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1323661000491 NAD binding site [chemical binding]; other site 1323661000492 homotetramer interface [polypeptide binding]; other site 1323661000493 homodimer interface [polypeptide binding]; other site 1323661000494 active site 1323661000495 substrate binding site [chemical binding]; other site 1323661000496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661000497 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1323661000498 NAD(P) binding site [chemical binding]; other site 1323661000499 active site 1323661000500 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1323661000501 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1323661000502 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1323661000503 putative ADP-binding pocket [chemical binding]; other site 1323661000504 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1323661000505 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1323661000506 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1323661000507 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1323661000508 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1323661000509 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1323661000510 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1323661000511 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1323661000512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1323661000513 DNA-binding site [nucleotide binding]; DNA binding site 1323661000514 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1323661000515 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1323661000516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661000517 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1323661000518 intersubunit interface [polypeptide binding]; other site 1323661000519 active site 1323661000520 catalytic residue [active] 1323661000521 phosphopentomutase; Region: deoB; TIGR01696 1323661000522 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1323661000523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661000524 dimer interface [polypeptide binding]; other site 1323661000525 conserved gate region; other site 1323661000526 putative PBP binding loops; other site 1323661000527 ABC-ATPase subunit interface; other site 1323661000528 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1323661000529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661000530 dimer interface [polypeptide binding]; other site 1323661000531 conserved gate region; other site 1323661000532 putative PBP binding loops; other site 1323661000533 ABC-ATPase subunit interface; other site 1323661000534 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1323661000535 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1323661000536 Walker A/P-loop; other site 1323661000537 ATP binding site [chemical binding]; other site 1323661000538 Q-loop/lid; other site 1323661000539 ABC transporter signature motif; other site 1323661000540 Walker B; other site 1323661000541 D-loop; other site 1323661000542 H-loop/switch region; other site 1323661000543 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1323661000544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1323661000545 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1323661000546 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1323661000547 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1323661000548 active site 1323661000549 metal binding site [ion binding]; metal-binding site 1323661000550 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1323661000551 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1323661000552 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1323661000553 putative catalytic cysteine [active] 1323661000554 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1323661000555 putative active site [active] 1323661000556 metal binding site [ion binding]; metal-binding site 1323661000557 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1323661000558 Chain length determinant protein; Region: Wzz; pfam02706 1323661000559 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1323661000560 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1323661000561 AAA domain; Region: AAA_31; pfam13614 1323661000562 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1323661000563 PHP domain; Region: PHP; pfam02811 1323661000564 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1323661000565 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1323661000566 NAD(P) binding site [chemical binding]; other site 1323661000567 homodimer interface [polypeptide binding]; other site 1323661000568 substrate binding site [chemical binding]; other site 1323661000569 active site 1323661000570 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1323661000571 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1323661000572 NAD(P) binding site [chemical binding]; other site 1323661000573 homodimer interface [polypeptide binding]; other site 1323661000574 substrate binding site [chemical binding]; other site 1323661000575 active site 1323661000576 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1323661000577 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1323661000578 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1323661000579 putative NAD(P) binding site [chemical binding]; other site 1323661000580 active site 1323661000581 putative substrate binding site [chemical binding]; other site 1323661000582 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1323661000583 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1323661000584 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1323661000585 active site 1323661000586 homodimer interface [polypeptide binding]; other site 1323661000587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1323661000588 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1323661000589 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1323661000590 trimer interface [polypeptide binding]; other site 1323661000591 active site 1323661000592 substrate binding site [chemical binding]; other site 1323661000593 CoA binding site [chemical binding]; other site 1323661000594 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1323661000595 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1323661000596 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1323661000597 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1323661000598 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1323661000599 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1323661000600 putative NAD(P) binding site [chemical binding]; other site 1323661000601 active site 1323661000602 putative substrate binding site [chemical binding]; other site 1323661000603 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1323661000604 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1323661000605 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1323661000606 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1323661000607 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1323661000608 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1323661000609 active site 1323661000610 homodimer interface [polypeptide binding]; other site 1323661000611 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1323661000612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1323661000613 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1323661000614 NAD(P) binding site [chemical binding]; other site 1323661000615 catalytic residues [active] 1323661000616 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1323661000617 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1323661000618 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1323661000619 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1323661000620 Walker A/P-loop; other site 1323661000621 ATP binding site [chemical binding]; other site 1323661000622 Q-loop/lid; other site 1323661000623 ABC transporter signature motif; other site 1323661000624 Walker B; other site 1323661000625 D-loop; other site 1323661000626 H-loop/switch region; other site 1323661000627 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1323661000628 NMT1-like family; Region: NMT1_2; cl17432 1323661000629 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1323661000630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661000631 dimer interface [polypeptide binding]; other site 1323661000632 conserved gate region; other site 1323661000633 putative PBP binding loops; other site 1323661000634 ABC-ATPase subunit interface; other site 1323661000635 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1323661000636 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1323661000637 active site 1323661000638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661000639 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661000640 putative substrate translocation pore; other site 1323661000641 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1323661000642 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1323661000643 acyl-activating enzyme (AAE) consensus motif; other site 1323661000644 AMP binding site [chemical binding]; other site 1323661000645 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1323661000646 Condensation domain; Region: Condensation; pfam00668 1323661000647 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1323661000648 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1323661000649 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1323661000650 acyl-activating enzyme (AAE) consensus motif; other site 1323661000651 AMP binding site [chemical binding]; other site 1323661000652 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1323661000653 thioester reductase domain; Region: Thioester-redct; TIGR01746 1323661000654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661000655 NAD(P) binding site [chemical binding]; other site 1323661000656 active site 1323661000657 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1323661000658 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1323661000659 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1323661000660 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1323661000661 nucleotide binding site [chemical binding]; other site 1323661000662 N-acetyl-L-glutamate binding site [chemical binding]; other site 1323661000663 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1323661000664 heterotetramer interface [polypeptide binding]; other site 1323661000665 active site pocket [active] 1323661000666 cleavage site 1323661000667 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1323661000668 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 1323661000669 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 1323661000670 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1323661000671 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1323661000672 inhibitor-cofactor binding pocket; inhibition site 1323661000673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661000674 catalytic residue [active] 1323661000675 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1323661000676 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1323661000677 catalytic triad [active] 1323661000678 conserved cis-peptide bond; other site 1323661000679 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1323661000680 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1323661000681 dimer interface [polypeptide binding]; other site 1323661000682 PYR/PP interface [polypeptide binding]; other site 1323661000683 TPP binding site [chemical binding]; other site 1323661000684 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1323661000685 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1323661000686 TPP-binding site [chemical binding]; other site 1323661000687 dimer interface [polypeptide binding]; other site 1323661000688 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1323661000689 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1323661000690 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1323661000691 active site turn [active] 1323661000692 phosphorylation site [posttranslational modification] 1323661000693 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1323661000694 HPr interaction site; other site 1323661000695 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1323661000696 active site 1323661000697 phosphorylation site [posttranslational modification] 1323661000698 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1323661000699 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 1323661000700 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1323661000701 putative active site [active] 1323661000702 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1323661000703 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1323661000704 active site turn [active] 1323661000705 phosphorylation site [posttranslational modification] 1323661000706 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1323661000707 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1323661000708 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1323661000709 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1323661000710 putative active site [active] 1323661000711 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1323661000712 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1323661000713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661000714 ATP binding site [chemical binding]; other site 1323661000715 putative Mg++ binding site [ion binding]; other site 1323661000716 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 1323661000717 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1323661000718 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1323661000719 Walker A/P-loop; other site 1323661000720 ATP binding site [chemical binding]; other site 1323661000721 Q-loop/lid; other site 1323661000722 ABC transporter signature motif; other site 1323661000723 Walker B; other site 1323661000724 D-loop; other site 1323661000725 H-loop/switch region; other site 1323661000726 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1323661000727 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1323661000728 Walker A/P-loop; other site 1323661000729 ATP binding site [chemical binding]; other site 1323661000730 Q-loop/lid; other site 1323661000731 ABC transporter signature motif; other site 1323661000732 Walker B; other site 1323661000733 D-loop; other site 1323661000734 H-loop/switch region; other site 1323661000735 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1323661000736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661000737 dimer interface [polypeptide binding]; other site 1323661000738 conserved gate region; other site 1323661000739 putative PBP binding loops; other site 1323661000740 ABC-ATPase subunit interface; other site 1323661000741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1323661000742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661000743 dimer interface [polypeptide binding]; other site 1323661000744 conserved gate region; other site 1323661000745 putative PBP binding loops; other site 1323661000746 ABC-ATPase subunit interface; other site 1323661000747 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1323661000748 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1323661000749 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1323661000750 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1323661000751 Protein of unknown function, DUF576; Region: DUF576; cl04553 1323661000752 azoreductase; Reviewed; Region: PRK00170 1323661000753 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1323661000754 Peptidase family M23; Region: Peptidase_M23; pfam01551 1323661000755 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1323661000756 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1323661000757 Walker A/P-loop; other site 1323661000758 ATP binding site [chemical binding]; other site 1323661000759 Q-loop/lid; other site 1323661000760 ABC transporter signature motif; other site 1323661000761 Walker B; other site 1323661000762 D-loop; other site 1323661000763 H-loop/switch region; other site 1323661000764 TOBE domain; Region: TOBE; pfam03459 1323661000765 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1323661000766 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1323661000767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661000768 dimer interface [polypeptide binding]; other site 1323661000769 conserved gate region; other site 1323661000770 ABC-ATPase subunit interface; other site 1323661000771 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1323661000772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661000773 dimer interface [polypeptide binding]; other site 1323661000774 conserved gate region; other site 1323661000775 putative PBP binding loops; other site 1323661000776 ABC-ATPase subunit interface; other site 1323661000777 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1323661000778 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1323661000779 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1323661000780 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1323661000781 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1323661000782 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1323661000783 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1323661000784 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1323661000785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1323661000786 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1323661000787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661000788 putative substrate translocation pore; other site 1323661000789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661000790 active site 1323661000791 phosphorylation site [posttranslational modification] 1323661000792 intermolecular recognition site; other site 1323661000793 dimerization interface [polypeptide binding]; other site 1323661000794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1323661000795 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1323661000796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1323661000797 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1323661000798 Histidine kinase; Region: His_kinase; pfam06580 1323661000799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661000800 ATP binding site [chemical binding]; other site 1323661000801 Mg2+ binding site [ion binding]; other site 1323661000802 G-X-G motif; other site 1323661000803 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1323661000804 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1323661000805 Pyruvate formate lyase 1; Region: PFL1; cd01678 1323661000806 coenzyme A binding site [chemical binding]; other site 1323661000807 active site 1323661000808 catalytic residues [active] 1323661000809 glycine loop; other site 1323661000810 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1323661000811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661000812 FeS/SAM binding site; other site 1323661000813 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1323661000814 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1323661000815 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1323661000816 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1323661000817 putative active site [active] 1323661000818 catalytic site [active] 1323661000819 putative metal binding site [ion binding]; other site 1323661000820 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1323661000821 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1323661000822 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1323661000823 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1323661000824 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1323661000825 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1323661000826 dimer interface [polypeptide binding]; other site 1323661000827 active site 1323661000828 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1323661000829 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1323661000830 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1323661000831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1323661000832 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1323661000833 substrate binding site [chemical binding]; other site 1323661000834 oxyanion hole (OAH) forming residues; other site 1323661000835 trimer interface [polypeptide binding]; other site 1323661000836 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1323661000837 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1323661000838 active site 1323661000839 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1323661000840 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1323661000841 acyl-activating enzyme (AAE) consensus motif; other site 1323661000842 AMP binding site [chemical binding]; other site 1323661000843 active site 1323661000844 CoA binding site [chemical binding]; other site 1323661000845 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1323661000846 Coenzyme A transferase; Region: CoA_trans; smart00882 1323661000847 Coenzyme A transferase; Region: CoA_trans; cl17247 1323661000848 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1323661000849 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1323661000850 catalytic triad [active] 1323661000851 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1323661000852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1323661000853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1323661000854 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1323661000855 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1323661000856 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1323661000857 putative NAD(P) binding site [chemical binding]; other site 1323661000858 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1323661000859 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1323661000860 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1323661000861 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1323661000862 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1323661000863 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1323661000864 heme-binding site [chemical binding]; other site 1323661000865 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1323661000866 FAD binding pocket [chemical binding]; other site 1323661000867 FAD binding motif [chemical binding]; other site 1323661000868 phosphate binding motif [ion binding]; other site 1323661000869 beta-alpha-beta structure motif; other site 1323661000870 NAD binding pocket [chemical binding]; other site 1323661000871 Heme binding pocket [chemical binding]; other site 1323661000872 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1323661000873 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1323661000874 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1323661000875 NAD binding site [chemical binding]; other site 1323661000876 dimer interface [polypeptide binding]; other site 1323661000877 substrate binding site [chemical binding]; other site 1323661000878 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1323661000879 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1323661000880 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1323661000881 active site turn [active] 1323661000882 phosphorylation site [posttranslational modification] 1323661000883 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1323661000884 active site 1323661000885 tetramer interface [polypeptide binding]; other site 1323661000886 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1323661000887 Mga helix-turn-helix domain; Region: Mga; pfam05043 1323661000888 PRD domain; Region: PRD; pfam00874 1323661000889 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1323661000890 active site 1323661000891 P-loop; other site 1323661000892 phosphorylation site [posttranslational modification] 1323661000893 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1323661000894 active site 1323661000895 phosphorylation site [posttranslational modification] 1323661000896 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1323661000897 active site 1323661000898 phosphorylation site [posttranslational modification] 1323661000899 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1323661000900 active site 1323661000901 P-loop; other site 1323661000902 phosphorylation site [posttranslational modification] 1323661000903 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1323661000904 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1323661000905 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1323661000906 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1323661000907 putative NAD(P) binding site [chemical binding]; other site 1323661000908 catalytic Zn binding site [ion binding]; other site 1323661000909 structural Zn binding site [ion binding]; other site 1323661000910 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1323661000911 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1323661000912 putative NAD(P) binding site [chemical binding]; other site 1323661000913 catalytic Zn binding site [ion binding]; other site 1323661000914 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1323661000915 substrate binding site; other site 1323661000916 dimer interface; other site 1323661000917 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1323661000918 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1323661000919 putative NAD(P) binding site [chemical binding]; other site 1323661000920 putative catalytic Zn binding site [ion binding]; other site 1323661000921 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1323661000922 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1323661000923 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1323661000924 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1323661000925 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1323661000926 substrate binding site; other site 1323661000927 dimer interface; other site 1323661000928 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1323661000929 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1323661000930 putative NAD(P) binding site [chemical binding]; other site 1323661000931 putative catalytic Zn binding site [ion binding]; other site 1323661000932 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1323661000933 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1323661000934 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1323661000935 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1323661000936 active site 1323661000937 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1323661000938 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1323661000939 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1323661000940 Fe binding site [ion binding]; other site 1323661000941 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1323661000942 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1323661000943 GAF domain; Region: GAF; pfam01590 1323661000944 Histidine kinase; Region: His_kinase; pfam06580 1323661000945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661000946 ATP binding site [chemical binding]; other site 1323661000947 Mg2+ binding site [ion binding]; other site 1323661000948 G-X-G motif; other site 1323661000949 two-component response regulator; Provisional; Region: PRK14084 1323661000950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661000951 active site 1323661000952 phosphorylation site [posttranslational modification] 1323661000953 intermolecular recognition site; other site 1323661000954 dimerization interface [polypeptide binding]; other site 1323661000955 LytTr DNA-binding domain; Region: LytTR; pfam04397 1323661000956 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1323661000957 antiholin-like protein LrgB; Provisional; Region: PRK04288 1323661000958 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1323661000959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1323661000960 DNA-binding site [nucleotide binding]; DNA binding site 1323661000961 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1323661000962 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1323661000963 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1323661000964 HPr interaction site; other site 1323661000965 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1323661000966 active site 1323661000967 phosphorylation site [posttranslational modification] 1323661000968 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 1323661000969 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1323661000970 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1323661000971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661000972 S-adenosylmethionine binding site [chemical binding]; other site 1323661000973 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1323661000974 substrate binding site [chemical binding]; other site 1323661000975 dimer interface [polypeptide binding]; other site 1323661000976 ATP binding site [chemical binding]; other site 1323661000977 D-ribose pyranase; Provisional; Region: PRK11797 1323661000978 Sugar transport protein; Region: Sugar_transport; pfam06800 1323661000979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1323661000980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1323661000981 DNA binding site [nucleotide binding] 1323661000982 domain linker motif; other site 1323661000983 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1323661000984 dimerization interface [polypeptide binding]; other site 1323661000985 ligand binding site [chemical binding]; other site 1323661000986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1323661000987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661000988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661000989 putative substrate translocation pore; other site 1323661000990 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1323661000991 active site 1323661000992 Surface antigen [General function prediction only]; Region: COG3942 1323661000993 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1323661000994 Peptidase family M23; Region: Peptidase_M23; pfam01551 1323661000995 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1323661000996 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1323661000997 Walker A/P-loop; other site 1323661000998 ATP binding site [chemical binding]; other site 1323661000999 Q-loop/lid; other site 1323661001000 ABC transporter signature motif; other site 1323661001001 Walker B; other site 1323661001002 D-loop; other site 1323661001003 H-loop/switch region; other site 1323661001004 Surface antigen [General function prediction only]; Region: COG3942 1323661001005 CHAP domain; Region: CHAP; pfam05257 1323661001006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1323661001007 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1323661001008 Predicted membrane protein [Function unknown]; Region: COG1511 1323661001009 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 1323661001010 heterodimer interface [polypeptide binding]; other site 1323661001011 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1323661001012 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1323661001013 Uncharacterized small protein [Function unknown]; Region: COG5417 1323661001014 Predicted membrane protein [Function unknown]; Region: COG4499 1323661001015 TolA protein; Region: tolA_full; TIGR02794 1323661001016 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1323661001017 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1323661001018 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1323661001019 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1323661001020 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1323661001021 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1323661001022 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1323661001023 Protein of unknown function, DUF600; Region: DUF600; cl04640 1323661001024 Protein of unknown function, DUF600; Region: DUF600; cl04640 1323661001025 Protein of unknown function, DUF600; Region: DUF600; cl04640 1323661001026 Domain of unknown function with cystatin-like fold (DUF4467); Region: DUF4467; pfam14729 1323661001027 Protein of unknown function, DUF600; Region: DUF600; cl04640 1323661001028 Protein of unknown function, DUF600; Region: DUF600; cl04640 1323661001029 Protein of unknown function, DUF600; Region: DUF600; cl04640 1323661001030 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 1323661001031 Protein of unknown function, DUF600; Region: DUF600; cl04640 1323661001032 Protein of unknown function, DUF600; Region: DUF600; cl04640 1323661001033 Protein of unknown function, DUF600; Region: DUF600; cl04640 1323661001034 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1323661001035 Domain of unknown function with cystatin-like fold (DUF4467); Region: DUF4467; pfam14729 1323661001036 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1323661001037 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1323661001038 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1323661001039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661001040 active site 1323661001041 motif I; other site 1323661001042 motif II; other site 1323661001043 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1323661001044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1323661001045 FtsX-like permease family; Region: FtsX; pfam02687 1323661001046 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1323661001047 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1323661001048 Walker A/P-loop; other site 1323661001049 ATP binding site [chemical binding]; other site 1323661001050 Q-loop/lid; other site 1323661001051 ABC transporter signature motif; other site 1323661001052 Walker B; other site 1323661001053 D-loop; other site 1323661001054 H-loop/switch region; other site 1323661001055 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1323661001056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661001057 non-specific DNA binding site [nucleotide binding]; other site 1323661001058 salt bridge; other site 1323661001059 sequence-specific DNA binding site [nucleotide binding]; other site 1323661001060 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1323661001061 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1323661001062 substrate binding site [chemical binding]; other site 1323661001063 ATP binding site [chemical binding]; other site 1323661001064 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1323661001065 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1323661001066 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1323661001067 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1323661001068 Na binding site [ion binding]; other site 1323661001069 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1323661001070 inhibitor site; inhibition site 1323661001071 active site 1323661001072 dimer interface [polypeptide binding]; other site 1323661001073 catalytic residue [active] 1323661001074 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1323661001075 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1323661001076 nucleotide binding site [chemical binding]; other site 1323661001077 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1323661001078 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1323661001079 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1323661001080 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1323661001081 putative active site [active] 1323661001082 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1323661001083 putative active site cavity [active] 1323661001084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1323661001085 Nucleoside recognition; Region: Gate; pfam07670 1323661001086 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1323661001087 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1323661001088 PGAP1-like protein; Region: PGAP1; pfam07819 1323661001089 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1323661001090 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1323661001091 putative active site [active] 1323661001092 putative FMN binding site [chemical binding]; other site 1323661001093 putative substrate binding site [chemical binding]; other site 1323661001094 putative catalytic residue [active] 1323661001095 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1323661001096 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1323661001097 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1323661001098 lipoyl attachment site [posttranslational modification]; other site 1323661001099 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1323661001100 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1323661001101 putative ADP-ribose binding site [chemical binding]; other site 1323661001102 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1323661001103 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1323661001104 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1323661001105 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1323661001106 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1323661001107 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1323661001108 active site 1323661001109 P-loop; other site 1323661001110 phosphorylation site [posttranslational modification] 1323661001111 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1323661001112 active site 1323661001113 phosphorylation site [posttranslational modification] 1323661001114 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1323661001115 HTH domain; Region: HTH_11; pfam08279 1323661001116 HTH domain; Region: HTH_11; cl17392 1323661001117 PRD domain; Region: PRD; pfam00874 1323661001118 PRD domain; Region: PRD; pfam00874 1323661001119 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1323661001120 active site 1323661001121 P-loop; other site 1323661001122 phosphorylation site [posttranslational modification] 1323661001123 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1323661001124 active site 1323661001125 phosphorylation site [posttranslational modification] 1323661001126 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661001127 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1323661001128 putative DNA binding site [nucleotide binding]; other site 1323661001129 putative Zn2+ binding site [ion binding]; other site 1323661001130 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1323661001131 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1323661001132 MepB protein; Region: MepB; cl01985 1323661001133 MepB protein; Region: MepB; cl01985 1323661001134 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1323661001135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661001136 putative substrate translocation pore; other site 1323661001137 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1323661001138 Zn binding site [ion binding]; other site 1323661001139 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1323661001140 Zn binding site [ion binding]; other site 1323661001141 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 1323661001142 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1323661001143 Predicted flavoprotein [General function prediction only]; Region: COG0431 1323661001144 Predicted membrane protein [Function unknown]; Region: COG2855 1323661001145 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1323661001146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1323661001147 Imelysin; Region: Peptidase_M75; pfam09375 1323661001148 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1323661001149 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1323661001150 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1323661001151 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1323661001152 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1323661001153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661001154 non-specific DNA binding site [nucleotide binding]; other site 1323661001155 salt bridge; other site 1323661001156 sequence-specific DNA binding site [nucleotide binding]; other site 1323661001157 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1323661001158 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1323661001159 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1323661001160 Walker A/P-loop; other site 1323661001161 ATP binding site [chemical binding]; other site 1323661001162 Q-loop/lid; other site 1323661001163 ABC transporter signature motif; other site 1323661001164 Walker B; other site 1323661001165 D-loop; other site 1323661001166 H-loop/switch region; other site 1323661001167 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1323661001168 Predicted membrane protein [Function unknown]; Region: COG4292 1323661001169 putative acyltransferase; Provisional; Region: PRK05790 1323661001170 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1323661001171 dimer interface [polypeptide binding]; other site 1323661001172 active site 1323661001173 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1323661001174 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1323661001175 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1323661001176 THF binding site; other site 1323661001177 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1323661001178 substrate binding site [chemical binding]; other site 1323661001179 THF binding site; other site 1323661001180 zinc-binding site [ion binding]; other site 1323661001181 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1323661001182 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1323661001183 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1323661001184 FAD binding site [chemical binding]; other site 1323661001185 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1323661001186 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1323661001187 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1323661001188 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1323661001189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1323661001190 catalytic residue [active] 1323661001191 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 1323661001192 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1323661001193 catalytic residue [active] 1323661001194 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1323661001195 ParB-like nuclease domain; Region: ParB; smart00470 1323661001196 KorB domain; Region: KorB; pfam08535 1323661001197 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1323661001198 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1323661001199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 1323661001200 GTP-binding protein YchF; Reviewed; Region: PRK09601 1323661001201 YchF GTPase; Region: YchF; cd01900 1323661001202 G1 box; other site 1323661001203 GTP/Mg2+ binding site [chemical binding]; other site 1323661001204 Switch I region; other site 1323661001205 G2 box; other site 1323661001206 Switch II region; other site 1323661001207 G3 box; other site 1323661001208 G4 box; other site 1323661001209 G5 box; other site 1323661001210 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1323661001211 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1323661001212 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1323661001213 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1323661001214 dimer interface [polypeptide binding]; other site 1323661001215 ssDNA binding site [nucleotide binding]; other site 1323661001216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1323661001217 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1323661001218 Abi-like protein; Region: Abi_2; pfam07751 1323661001219 putative transposase OrfB; Reviewed; Region: PHA02517 1323661001220 HTH-like domain; Region: HTH_21; pfam13276 1323661001221 Integrase core domain; Region: rve; pfam00665 1323661001222 Integrase core domain; Region: rve_3; pfam13683 1323661001223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1323661001224 Transposase; Region: HTH_Tnp_1; cl17663 1323661001225 Abi-like protein; Region: Abi_2; cl01988 1323661001226 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1323661001227 superantigen-like protein; Reviewed; Region: PRK13042 1323661001228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1323661001229 Predicted membrane protein [Function unknown]; Region: COG3212 1323661001230 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1323661001231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661001232 non-specific DNA binding site [nucleotide binding]; other site 1323661001233 salt bridge; other site 1323661001234 sequence-specific DNA binding site [nucleotide binding]; other site 1323661001235 Predicted membrane protein [Function unknown]; Region: COG2261 1323661001236 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1323661001237 catalytic core [active] 1323661001238 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1323661001239 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1323661001240 catalytic residue [active] 1323661001241 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1323661001242 catalytic residues [active] 1323661001243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661001244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661001245 peroxiredoxin; Region: AhpC; TIGR03137 1323661001246 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1323661001247 dimer interface [polypeptide binding]; other site 1323661001248 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1323661001249 catalytic triad [active] 1323661001250 peroxidatic and resolving cysteines [active] 1323661001251 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1323661001252 dimer interface [polypeptide binding]; other site 1323661001253 FMN binding site [chemical binding]; other site 1323661001254 NADPH bind site [chemical binding]; other site 1323661001255 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1323661001256 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1323661001257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661001258 active site 1323661001259 Sulfate transporter family; Region: Sulfate_transp; cl19250 1323661001260 xanthine permease; Region: pbuX; TIGR03173 1323661001261 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1323661001262 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1323661001263 active site 1323661001264 GMP synthase; Reviewed; Region: guaA; PRK00074 1323661001265 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1323661001266 AMP/PPi binding site [chemical binding]; other site 1323661001267 candidate oxyanion hole; other site 1323661001268 catalytic triad [active] 1323661001269 potential glutamine specificity residues [chemical binding]; other site 1323661001270 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1323661001271 ATP Binding subdomain [chemical binding]; other site 1323661001272 Ligand Binding sites [chemical binding]; other site 1323661001273 Dimerization subdomain; other site 1323661001274 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1323661001275 RNA helicase NPH-II; Provisional; Region: PHA02653 1323661001276 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1323661001277 PemK-like protein; Region: PemK; pfam02452 1323661001278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1323661001279 Transposase; Region: HTH_Tnp_1; cl17663 1323661001280 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1323661001281 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1323661001282 Predicted membrane protein [Function unknown]; Region: COG3759 1323661001283 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1323661001284 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1323661001285 NADP binding site [chemical binding]; other site 1323661001286 superantigen-like protein; Reviewed; Region: PRK13037 1323661001287 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1323661001288 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661001289 superantigen-like protein; Reviewed; Region: PRK13041 1323661001290 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1323661001291 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661001292 superantigen-like protein; Reviewed; Region: PRK13335 1323661001293 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1323661001294 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661001295 superantigen-like protein; Reviewed; Region: PRK13042 1323661001296 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1323661001297 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661001298 superantigen-like protein 5; Reviewed; Region: PRK13035 1323661001299 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1323661001300 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661001301 superantigen-like protein; Reviewed; Region: PRK13345 1323661001302 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1323661001303 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661001304 superantigen-like protein; Reviewed; Region: PRK13038 1323661001305 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1323661001306 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661001307 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1323661001308 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1323661001309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661001310 S-adenosylmethionine binding site [chemical binding]; other site 1323661001311 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1323661001312 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1323661001313 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1323661001314 superantigen-like protein; Reviewed; Region: PRK13036 1323661001315 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1323661001316 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661001317 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1323661001318 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1323661001319 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1323661001320 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1323661001321 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1323661001322 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1323661001323 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1323661001324 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1323661001325 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1323661001326 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1323661001327 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1323661001328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1323661001329 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1323661001330 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1323661001331 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1323661001332 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1323661001333 active site 1323661001334 Esterase/lipase [General function prediction only]; Region: COG1647 1323661001335 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1323661001336 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1323661001337 Na2 binding site [ion binding]; other site 1323661001338 putative substrate binding site 1 [chemical binding]; other site 1323661001339 Na binding site 1 [ion binding]; other site 1323661001340 putative substrate binding site 2 [chemical binding]; other site 1323661001341 cysteine synthase; Region: PLN02565 1323661001342 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1323661001343 dimer interface [polypeptide binding]; other site 1323661001344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661001345 catalytic residue [active] 1323661001346 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1323661001347 homodimer interface [polypeptide binding]; other site 1323661001348 substrate-cofactor binding pocket; other site 1323661001349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661001350 catalytic residue [active] 1323661001351 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1323661001352 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1323661001353 Walker A/P-loop; other site 1323661001354 ATP binding site [chemical binding]; other site 1323661001355 Q-loop/lid; other site 1323661001356 ABC transporter signature motif; other site 1323661001357 Walker B; other site 1323661001358 D-loop; other site 1323661001359 H-loop/switch region; other site 1323661001360 NIL domain; Region: NIL; pfam09383 1323661001361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661001362 dimer interface [polypeptide binding]; other site 1323661001363 conserved gate region; other site 1323661001364 ABC-ATPase subunit interface; other site 1323661001365 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1323661001366 LysM domain; Region: LysM; pfam01476 1323661001367 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1323661001368 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1323661001369 Surface antigen [General function prediction only]; Region: COG3942 1323661001370 CHAP domain; Region: CHAP; pfam05257 1323661001371 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1323661001372 nudix motif; other site 1323661001373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661001374 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1323661001375 Coenzyme A binding pocket [chemical binding]; other site 1323661001376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1323661001377 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1323661001378 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1323661001379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1323661001380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1323661001381 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1323661001382 dimerization interface [polypeptide binding]; other site 1323661001383 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1323661001384 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1323661001385 active site 1323661001386 dimer interface [polypeptide binding]; other site 1323661001387 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1323661001388 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1323661001389 active site 1323661001390 FMN binding site [chemical binding]; other site 1323661001391 substrate binding site [chemical binding]; other site 1323661001392 3Fe-4S cluster binding site [ion binding]; other site 1323661001393 Glutamate synthase domain 3 [Amino acid transport and metabolism]; Region: GltB; COG0070 1323661001394 domain_subunit interface; other site 1323661001395 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1323661001396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1323661001397 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1323661001398 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1323661001399 active site turn [active] 1323661001400 phosphorylation site [posttranslational modification] 1323661001401 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1323661001402 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1323661001403 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1323661001404 Ca binding site [ion binding]; other site 1323661001405 active site 1323661001406 catalytic site [active] 1323661001407 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1323661001408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1323661001409 DNA-binding site [nucleotide binding]; DNA binding site 1323661001410 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1323661001411 UTRA domain; Region: UTRA; pfam07702 1323661001412 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1323661001413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661001414 Coenzyme A binding pocket [chemical binding]; other site 1323661001415 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1323661001416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661001417 Walker A motif; other site 1323661001418 ATP binding site [chemical binding]; other site 1323661001419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 1323661001420 Walker B motif; other site 1323661001421 arginine finger; other site 1323661001422 hypothetical protein; Validated; Region: PRK00153 1323661001423 recombination protein RecR; Reviewed; Region: recR; PRK00076 1323661001424 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 1323661001425 RecR protein; Region: RecR; pfam02132 1323661001426 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1323661001427 putative active site [active] 1323661001428 putative metal-binding site [ion binding]; other site 1323661001429 tetramer interface [polypeptide binding]; other site 1323661001430 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1323661001431 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 1323661001432 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1323661001433 catalytic residue [active] 1323661001434 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1323661001435 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1323661001436 thymidylate kinase; Validated; Region: tmk; PRK00698 1323661001437 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1323661001438 TMP-binding site; other site 1323661001439 ATP-binding site [chemical binding]; other site 1323661001440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1323661001441 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1323661001442 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1323661001443 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1323661001444 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1323661001445 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1323661001446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661001447 S-adenosylmethionine binding site [chemical binding]; other site 1323661001448 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1323661001449 GIY-YIG motif/motif A; other site 1323661001450 putative active site [active] 1323661001451 putative metal binding site [ion binding]; other site 1323661001452 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1323661001453 putative SAM binding site [chemical binding]; other site 1323661001454 putative homodimer interface [polypeptide binding]; other site 1323661001455 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1323661001456 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1323661001457 active site 1323661001458 HIGH motif; other site 1323661001459 KMSKS motif; other site 1323661001460 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1323661001461 tRNA binding surface [nucleotide binding]; other site 1323661001462 anticodon binding site; other site 1323661001463 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1323661001464 dimer interface [polypeptide binding]; other site 1323661001465 putative tRNA-binding site [nucleotide binding]; other site 1323661001466 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1323661001467 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1323661001468 active site 1323661001469 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1323661001470 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1323661001471 putative active site [active] 1323661001472 putative metal binding site [ion binding]; other site 1323661001473 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1323661001474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661001475 S-adenosylmethionine binding site [chemical binding]; other site 1323661001476 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1323661001477 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1323661001478 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1323661001479 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1323661001480 pur operon repressor; Provisional; Region: PRK09213 1323661001481 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1323661001482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661001483 active site 1323661001484 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1323661001485 homotrimer interaction site [polypeptide binding]; other site 1323661001486 putative active site [active] 1323661001487 regulatory protein SpoVG; Reviewed; Region: PRK13259 1323661001488 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1323661001489 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1323661001490 Substrate binding site; other site 1323661001491 Mg++ binding site; other site 1323661001492 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1323661001493 active site 1323661001494 substrate binding site [chemical binding]; other site 1323661001495 CoA binding site [chemical binding]; other site 1323661001496 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1323661001497 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1323661001498 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661001499 active site 1323661001500 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1323661001501 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1323661001502 5S rRNA interface [nucleotide binding]; other site 1323661001503 CTC domain interface [polypeptide binding]; other site 1323661001504 L16 interface [polypeptide binding]; other site 1323661001505 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 1323661001506 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1323661001507 putative active site [active] 1323661001508 catalytic residue [active] 1323661001509 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1323661001510 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 1323661001511 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1323661001512 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661001513 ATP binding site [chemical binding]; other site 1323661001514 putative Mg++ binding site [ion binding]; other site 1323661001515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661001516 nucleotide binding region [chemical binding]; other site 1323661001517 ATP-binding site [chemical binding]; other site 1323661001518 TRCF domain; Region: TRCF; pfam03461 1323661001519 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1323661001520 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1323661001521 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1323661001522 putative SAM binding site [chemical binding]; other site 1323661001523 putative homodimer interface [polypeptide binding]; other site 1323661001524 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1323661001525 homodimer interface [polypeptide binding]; other site 1323661001526 metal binding site [ion binding]; metal-binding site 1323661001527 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1323661001528 RNA binding surface [nucleotide binding]; other site 1323661001529 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1323661001530 Septum formation initiator; Region: DivIC; pfam04977 1323661001531 hypothetical protein; Provisional; Region: PRK08582 1323661001532 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1323661001533 RNA binding site [nucleotide binding]; other site 1323661001534 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1323661001535 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1323661001536 Ligand Binding Site [chemical binding]; other site 1323661001537 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1323661001538 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661001539 active site 1323661001540 FtsH Extracellular; Region: FtsH_ext; pfam06480 1323661001541 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1323661001542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661001543 Walker A motif; other site 1323661001544 ATP binding site [chemical binding]; other site 1323661001545 Walker B motif; other site 1323661001546 arginine finger; other site 1323661001547 Peptidase family M41; Region: Peptidase_M41; pfam01434 1323661001548 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1323661001549 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1323661001550 dimerization interface [polypeptide binding]; other site 1323661001551 domain crossover interface; other site 1323661001552 redox-dependent activation switch; other site 1323661001553 cysteine synthase; Region: PLN02565 1323661001554 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1323661001555 dimer interface [polypeptide binding]; other site 1323661001556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661001557 catalytic residue [active] 1323661001558 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1323661001559 dihydropteroate synthase; Region: DHPS; TIGR01496 1323661001560 substrate binding pocket [chemical binding]; other site 1323661001561 dimer interface [polypeptide binding]; other site 1323661001562 inhibitor binding site; inhibition site 1323661001563 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1323661001564 homooctamer interface [polypeptide binding]; other site 1323661001565 active site 1323661001566 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1323661001567 catalytic center binding site [active] 1323661001568 ATP binding site [chemical binding]; other site 1323661001569 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1323661001570 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1323661001571 dimer interface [polypeptide binding]; other site 1323661001572 putative anticodon binding site; other site 1323661001573 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1323661001574 motif 1; other site 1323661001575 active site 1323661001576 motif 2; other site 1323661001577 motif 3; other site 1323661001578 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1323661001579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1323661001580 DNA-binding site [nucleotide binding]; DNA binding site 1323661001581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1323661001582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661001583 homodimer interface [polypeptide binding]; other site 1323661001584 catalytic residue [active] 1323661001585 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1323661001586 active site 1323661001587 multimer interface [polypeptide binding]; other site 1323661001588 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1323661001589 predicted active site [active] 1323661001590 catalytic triad [active] 1323661001591 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1323661001592 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1323661001593 Nucleoside recognition; Region: Gate; pfam07670 1323661001594 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1323661001595 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1323661001596 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1323661001597 UvrB/uvrC motif; Region: UVR; pfam02151 1323661001598 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1323661001599 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1323661001600 ADP binding site [chemical binding]; other site 1323661001601 phosphagen binding site; other site 1323661001602 substrate specificity loop; other site 1323661001603 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1323661001604 Clp amino terminal domain; Region: Clp_N; pfam02861 1323661001605 Clp amino terminal domain; Region: Clp_N; pfam02861 1323661001606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661001607 Walker A motif; other site 1323661001608 ATP binding site [chemical binding]; other site 1323661001609 Walker B motif; other site 1323661001610 arginine finger; other site 1323661001611 UvrB/uvrC motif; Region: UVR; pfam02151 1323661001612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661001613 Walker A motif; other site 1323661001614 ATP binding site [chemical binding]; other site 1323661001615 Walker B motif; other site 1323661001616 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1323661001617 DNA repair protein RadA; Provisional; Region: PRK11823 1323661001618 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1323661001619 Walker A motif/ATP binding site; other site 1323661001620 ATP binding site [chemical binding]; other site 1323661001621 Walker B motif; other site 1323661001622 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1323661001623 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1323661001624 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1323661001625 putative active site [active] 1323661001626 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1323661001627 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1323661001628 active site 1323661001629 HIGH motif; other site 1323661001630 KMSKS motif; other site 1323661001631 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1323661001632 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1323661001633 trimer interface [polypeptide binding]; other site 1323661001634 active site 1323661001635 substrate binding site [chemical binding]; other site 1323661001636 CoA binding site [chemical binding]; other site 1323661001637 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1323661001638 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1323661001639 active site 1323661001640 HIGH motif; other site 1323661001641 KMSKS motif; other site 1323661001642 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1323661001643 tRNA binding surface [nucleotide binding]; other site 1323661001644 anticodon binding site; other site 1323661001645 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1323661001646 dimerization interface [polypeptide binding]; other site 1323661001647 active site 1323661001648 metal binding site [ion binding]; metal-binding site 1323661001649 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1323661001650 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1323661001651 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1323661001652 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1323661001653 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1323661001654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1323661001655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1323661001656 DNA binding residues [nucleotide binding] 1323661001657 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1323661001658 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1323661001659 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1323661001660 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1323661001661 putative homodimer interface [polypeptide binding]; other site 1323661001662 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1323661001663 heterodimer interface [polypeptide binding]; other site 1323661001664 homodimer interface [polypeptide binding]; other site 1323661001665 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1323661001666 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1323661001667 23S rRNA interface [nucleotide binding]; other site 1323661001668 L7/L12 interface [polypeptide binding]; other site 1323661001669 putative thiostrepton binding site; other site 1323661001670 L25 interface [polypeptide binding]; other site 1323661001671 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1323661001672 mRNA/rRNA interface [nucleotide binding]; other site 1323661001673 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1323661001674 23S rRNA interface [nucleotide binding]; other site 1323661001675 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1323661001676 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1323661001677 peripheral dimer interface [polypeptide binding]; other site 1323661001678 core dimer interface [polypeptide binding]; other site 1323661001679 L10 interface [polypeptide binding]; other site 1323661001680 L11 interface [polypeptide binding]; other site 1323661001681 putative EF-Tu interaction site [polypeptide binding]; other site 1323661001682 putative EF-G interaction site [polypeptide binding]; other site 1323661001683 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1323661001684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661001685 S-adenosylmethionine binding site [chemical binding]; other site 1323661001686 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1323661001687 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1323661001688 RPB12 interaction site [polypeptide binding]; other site 1323661001689 RPB1 interaction site [polypeptide binding]; other site 1323661001690 RPB10 interaction site [polypeptide binding]; other site 1323661001691 RPB11 interaction site [polypeptide binding]; other site 1323661001692 RPB3 interaction site [polypeptide binding]; other site 1323661001693 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1323661001694 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 1323661001695 beta and beta' interface [polypeptide binding]; other site 1323661001696 beta' and sigma factor interface [polypeptide binding]; other site 1323661001697 Zn-binding [ion binding]; other site 1323661001698 active site region [active] 1323661001699 catalytic site [active] 1323661001700 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1323661001701 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1323661001702 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1323661001703 G-loop; other site 1323661001704 DNA binding site [nucleotide binding] 1323661001705 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1323661001706 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1323661001707 S17 interaction site [polypeptide binding]; other site 1323661001708 S8 interaction site; other site 1323661001709 16S rRNA interaction site [nucleotide binding]; other site 1323661001710 streptomycin interaction site [chemical binding]; other site 1323661001711 23S rRNA interaction site [nucleotide binding]; other site 1323661001712 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1323661001713 30S ribosomal protein S7; Validated; Region: PRK05302 1323661001714 elongation factor G; Reviewed; Region: PRK00007 1323661001715 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1323661001716 G1 box; other site 1323661001717 putative GEF interaction site [polypeptide binding]; other site 1323661001718 GTP/Mg2+ binding site [chemical binding]; other site 1323661001719 Switch I region; other site 1323661001720 G2 box; other site 1323661001721 G3 box; other site 1323661001722 Switch II region; other site 1323661001723 G4 box; other site 1323661001724 G5 box; other site 1323661001725 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1323661001726 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1323661001727 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1323661001728 elongation factor Tu; Reviewed; Region: PRK00049 1323661001729 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1323661001730 G1 box; other site 1323661001731 GEF interaction site [polypeptide binding]; other site 1323661001732 GTP/Mg2+ binding site [chemical binding]; other site 1323661001733 Switch I region; other site 1323661001734 G2 box; other site 1323661001735 G3 box; other site 1323661001736 Switch II region; other site 1323661001737 G4 box; other site 1323661001738 G5 box; other site 1323661001739 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1323661001740 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1323661001741 Antibiotic Binding Site [chemical binding]; other site 1323661001742 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1323661001743 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1323661001744 metal binding site [ion binding]; metal-binding site 1323661001745 dimer interface [polypeptide binding]; other site 1323661001746 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 1323661001747 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1323661001748 substrate-cofactor binding pocket; other site 1323661001749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661001750 catalytic residue [active] 1323661001751 chaperone protein HchA; Provisional; Region: PRK04155 1323661001752 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1323661001753 dimer interface [polypeptide binding]; other site 1323661001754 metal binding site [ion binding]; metal-binding site 1323661001755 potential oxyanion hole; other site 1323661001756 potential catalytic triad [active] 1323661001757 conserved cys residue [active] 1323661001758 ribulokinase; Provisional; Region: PRK04123 1323661001759 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1323661001760 N- and C-terminal domain interface [polypeptide binding]; other site 1323661001761 active site 1323661001762 MgATP binding site [chemical binding]; other site 1323661001763 catalytic site [active] 1323661001764 metal binding site [ion binding]; metal-binding site 1323661001765 carbohydrate binding site [chemical binding]; other site 1323661001766 homodimer interface [polypeptide binding]; other site 1323661001767 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1323661001768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661001769 NAD(P) binding site [chemical binding]; other site 1323661001770 active site 1323661001771 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1323661001772 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1323661001773 homodimer interface [polypeptide binding]; other site 1323661001774 substrate-cofactor binding pocket; other site 1323661001775 catalytic residue [active] 1323661001776 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1323661001777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661001778 motif II; other site 1323661001779 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1323661001780 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1323661001781 Substrate-binding site [chemical binding]; other site 1323661001782 Substrate specificity [chemical binding]; other site 1323661001783 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1323661001784 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1323661001785 Substrate-binding site [chemical binding]; other site 1323661001786 Substrate specificity [chemical binding]; other site 1323661001787 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1323661001788 nucleoside/Zn binding site; other site 1323661001789 dimer interface [polypeptide binding]; other site 1323661001790 catalytic motif [active] 1323661001791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661001792 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1323661001793 active site 1323661001794 motif I; other site 1323661001795 motif II; other site 1323661001796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661001797 Predicted flavoprotein [General function prediction only]; Region: COG0431 1323661001798 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661001799 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1323661001800 Cna protein B-type domain; Region: Cna_B; pfam05738 1323661001801 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1323661001802 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661001803 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1323661001804 Cna protein B-type domain; Region: Cna_B; pfam05738 1323661001805 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1323661001806 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1323661001807 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1323661001808 Cna protein B-type domain; Region: Cna_B; pfam05738 1323661001809 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661001810 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1323661001811 Surface protein; Region: DUF3664; pfam12406 1323661001812 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1323661001813 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1323661001814 Cna protein B-type domain; Region: Cna_B; pfam05738 1323661001815 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1323661001816 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1323661001817 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1323661001818 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1323661001819 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1323661001820 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1323661001821 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1323661001822 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1323661001823 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1323661001824 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1323661001825 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1323661001826 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1323661001827 active site 1323661001828 trimer interface [polypeptide binding]; other site 1323661001829 allosteric site; other site 1323661001830 active site lid [active] 1323661001831 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1323661001832 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1323661001833 active site 1323661001834 dimer interface [polypeptide binding]; other site 1323661001835 magnesium binding site [ion binding]; other site 1323661001836 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1323661001837 tetramer interface [polypeptide binding]; other site 1323661001838 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1323661001839 active site 1323661001840 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1323661001841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661001842 motif II; other site 1323661001843 proline/glycine betaine transporter; Provisional; Region: PRK10642 1323661001844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661001845 putative substrate translocation pore; other site 1323661001846 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1323661001847 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1323661001848 acyl-activating enzyme (AAE) consensus motif; other site 1323661001849 AMP binding site [chemical binding]; other site 1323661001850 active site 1323661001851 CoA binding site [chemical binding]; other site 1323661001852 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1323661001853 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1323661001854 dimer interface [polypeptide binding]; other site 1323661001855 active site 1323661001856 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1323661001857 dimer interface [polypeptide binding]; other site 1323661001858 substrate binding site [chemical binding]; other site 1323661001859 ATP binding site [chemical binding]; other site 1323661001860 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1323661001861 ligand binding site [chemical binding]; other site 1323661001862 active site 1323661001863 UGI interface [polypeptide binding]; other site 1323661001864 catalytic site [active] 1323661001865 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1323661001866 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1323661001867 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1323661001868 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1323661001869 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1323661001870 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1323661001871 putative heme peroxidase; Provisional; Region: PRK12276 1323661001872 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1323661001873 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1323661001874 mevalonate kinase; Region: mevalon_kin; TIGR00549 1323661001875 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1323661001876 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1323661001877 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1323661001878 diphosphomevalonate decarboxylase; Region: PLN02407 1323661001879 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1323661001880 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1323661001881 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1323661001882 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1323661001883 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1323661001884 Squalene epoxidase; Region: SE; cl17314 1323661001885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661001886 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661001887 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1323661001888 Predicted transcriptional regulator [Transcription]; Region: COG1959 1323661001889 Rrf2 family protein; Region: rrf2_super; TIGR00738 1323661001890 LXG domain of WXG superfamily; Region: LXG; pfam04740 1323661001891 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1323661001892 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1323661001893 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1323661001894 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1323661001895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1323661001896 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1323661001897 active site 1323661001898 catalytic tetrad [active] 1323661001899 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1323661001900 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1323661001901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661001902 Coenzyme A binding pocket [chemical binding]; other site 1323661001903 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1323661001904 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1323661001905 Zn2+ binding site [ion binding]; other site 1323661001906 Mg2+ binding site [ion binding]; other site 1323661001907 YwhD family; Region: YwhD; pfam08741 1323661001908 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1323661001909 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1323661001910 NAD binding site [chemical binding]; other site 1323661001911 substrate binding site [chemical binding]; other site 1323661001912 catalytic Zn binding site [ion binding]; other site 1323661001913 tetramer interface [polypeptide binding]; other site 1323661001914 structural Zn binding site [ion binding]; other site 1323661001915 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1323661001916 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1323661001917 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1323661001918 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1323661001919 active site 1323661001920 HIGH motif; other site 1323661001921 KMSK motif region; other site 1323661001922 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1323661001923 tRNA binding surface [nucleotide binding]; other site 1323661001924 anticodon binding site; other site 1323661001925 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1323661001926 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1323661001927 minor groove reading motif; other site 1323661001928 helix-hairpin-helix signature motif; other site 1323661001929 substrate binding pocket [chemical binding]; other site 1323661001930 active site 1323661001931 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1323661001932 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1323661001933 putative binding site residues; other site 1323661001934 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661001935 ABC-ATPase subunit interface; other site 1323661001936 dimer interface [polypeptide binding]; other site 1323661001937 putative PBP binding regions; other site 1323661001938 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1323661001939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661001940 motif II; other site 1323661001941 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1323661001942 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1323661001943 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1323661001944 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1323661001945 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1323661001946 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661001947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1323661001948 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1323661001949 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1323661001950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1323661001951 active site 1323661001952 DNA binding site [nucleotide binding] 1323661001953 Int/Topo IB signature motif; other site 1323661001954 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1323661001955 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1323661001956 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1323661001957 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1323661001958 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1323661001959 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1323661001960 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1323661001961 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1323661001962 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1323661001963 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1323661001964 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1323661001965 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1323661001966 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1323661001967 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1323661001968 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1323661001969 metal binding site [ion binding]; metal-binding site 1323661001970 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661001971 ABC-ATPase subunit interface; other site 1323661001972 dimer interface [polypeptide binding]; other site 1323661001973 putative PBP binding regions; other site 1323661001974 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1323661001975 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1323661001976 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1323661001977 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1323661001978 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1323661001979 FeoA domain; Region: FeoA; pfam04023 1323661001980 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1323661001981 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1323661001982 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1323661001983 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1323661001984 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1323661001985 Walker A/P-loop; other site 1323661001986 ATP binding site [chemical binding]; other site 1323661001987 Q-loop/lid; other site 1323661001988 ABC transporter signature motif; other site 1323661001989 Walker B; other site 1323661001990 D-loop; other site 1323661001991 H-loop/switch region; other site 1323661001992 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1323661001993 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1323661001994 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1323661001995 active site 1323661001996 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1323661001997 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1323661001998 active site 1323661001999 nucleotide binding site [chemical binding]; other site 1323661002000 HIGH motif; other site 1323661002001 KMSKS motif; other site 1323661002002 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1323661002003 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 1323661002004 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1323661002005 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1323661002006 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1323661002007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661002008 Walker A/P-loop; other site 1323661002009 ATP binding site [chemical binding]; other site 1323661002010 Q-loop/lid; other site 1323661002011 ABC transporter signature motif; other site 1323661002012 Walker B; other site 1323661002013 D-loop; other site 1323661002014 H-loop/switch region; other site 1323661002015 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1323661002016 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1323661002017 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1323661002018 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1323661002019 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1323661002020 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1323661002021 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1323661002022 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1323661002023 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1323661002024 Walker A/P-loop; other site 1323661002025 ATP binding site [chemical binding]; other site 1323661002026 Q-loop/lid; other site 1323661002027 ABC transporter signature motif; other site 1323661002028 Walker B; other site 1323661002029 D-loop; other site 1323661002030 H-loop/switch region; other site 1323661002031 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661002032 ABC-ATPase subunit interface; other site 1323661002033 dimer interface [polypeptide binding]; other site 1323661002034 putative PBP binding regions; other site 1323661002035 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661002036 ABC-ATPase subunit interface; other site 1323661002037 dimer interface [polypeptide binding]; other site 1323661002038 putative PBP binding regions; other site 1323661002039 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1323661002040 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1323661002041 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1323661002042 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1323661002043 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1323661002044 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1323661002045 Na binding site [ion binding]; other site 1323661002046 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1323661002047 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1323661002048 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1323661002049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661002050 Coenzyme A binding pocket [chemical binding]; other site 1323661002051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1323661002052 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1323661002053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661002054 NAD(P) binding site [chemical binding]; other site 1323661002055 active site 1323661002056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661002057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661002058 active site 1323661002059 phosphorylation site [posttranslational modification] 1323661002060 intermolecular recognition site; other site 1323661002061 dimerization interface [polypeptide binding]; other site 1323661002062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661002063 DNA binding site [nucleotide binding] 1323661002064 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1323661002065 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1323661002066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661002067 ATP binding site [chemical binding]; other site 1323661002068 Mg2+ binding site [ion binding]; other site 1323661002069 G-X-G motif; other site 1323661002070 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1323661002071 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1323661002072 Walker A/P-loop; other site 1323661002073 ATP binding site [chemical binding]; other site 1323661002074 Q-loop/lid; other site 1323661002075 ABC transporter signature motif; other site 1323661002076 Walker B; other site 1323661002077 D-loop; other site 1323661002078 H-loop/switch region; other site 1323661002079 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1323661002080 FtsX-like permease family; Region: FtsX; pfam02687 1323661002081 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1323661002082 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1323661002083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1323661002084 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1323661002085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1323661002086 Surface antigen [General function prediction only]; Region: COG3942 1323661002087 CHAP domain; Region: CHAP; pfam05257 1323661002088 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1323661002089 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1323661002090 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1323661002091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1323661002092 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1323661002093 hypothetical protein; Provisional; Region: PRK12378 1323661002094 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1323661002095 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1323661002096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1323661002097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1323661002098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1323661002099 dimerization interface [polypeptide binding]; other site 1323661002100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661002101 sugar efflux transporter; Region: 2A0120; TIGR00899 1323661002102 putative substrate translocation pore; other site 1323661002103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1323661002104 Serine incorporator (Serinc); Region: Serinc; pfam03348 1323661002105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661002106 Coenzyme A binding pocket [chemical binding]; other site 1323661002107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1323661002108 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1323661002109 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1323661002110 hypothetical protein; Validated; Region: PRK00124 1323661002111 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1323661002112 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1323661002113 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1323661002114 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1323661002115 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1323661002116 Walker A/P-loop; other site 1323661002117 ATP binding site [chemical binding]; other site 1323661002118 Q-loop/lid; other site 1323661002119 ABC transporter signature motif; other site 1323661002120 Walker B; other site 1323661002121 D-loop; other site 1323661002122 H-loop/switch region; other site 1323661002123 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1323661002124 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1323661002125 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1323661002126 Walker A/P-loop; other site 1323661002127 ATP binding site [chemical binding]; other site 1323661002128 Q-loop/lid; other site 1323661002129 ABC transporter signature motif; other site 1323661002130 Walker B; other site 1323661002131 D-loop; other site 1323661002132 H-loop/switch region; other site 1323661002133 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661002134 MarR family; Region: MarR; pfam01047 1323661002135 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1323661002136 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1323661002137 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1323661002138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1323661002139 active site 1323661002140 catalytic tetrad [active] 1323661002141 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1323661002142 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1323661002143 transmembrane helices; other site 1323661002144 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1323661002145 DNA photolyase; Region: DNA_photolyase; pfam00875 1323661002146 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1323661002147 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1323661002148 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1323661002149 trimer interface [polypeptide binding]; other site 1323661002150 putative Zn binding site [ion binding]; other site 1323661002151 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1323661002152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661002153 putative substrate translocation pore; other site 1323661002154 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1323661002155 putative deacylase active site [active] 1323661002156 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1323661002157 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1323661002158 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1323661002159 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1323661002160 putative substrate binding site [chemical binding]; other site 1323661002161 putative ATP binding site [chemical binding]; other site 1323661002162 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1323661002163 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1323661002164 active site 1323661002165 phosphorylation site [posttranslational modification] 1323661002166 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1323661002167 active site 1323661002168 P-loop; other site 1323661002169 phosphorylation site [posttranslational modification] 1323661002170 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1323661002171 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1323661002172 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1323661002173 active site 1323661002174 dimer interface [polypeptide binding]; other site 1323661002175 Domain of unknown function DUF21; Region: DUF21; pfam01595 1323661002176 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1323661002177 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1323661002178 Transporter associated domain; Region: CorC_HlyC; pfam03471 1323661002179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1323661002180 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1323661002181 active site 1323661002182 catalytic tetrad [active] 1323661002183 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1323661002184 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1323661002185 Ligand binding site; other site 1323661002186 Putative Catalytic site; other site 1323661002187 DXD motif; other site 1323661002188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1323661002189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1323661002190 dimer interface [polypeptide binding]; other site 1323661002191 phosphorylation site [posttranslational modification] 1323661002192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661002193 ATP binding site [chemical binding]; other site 1323661002194 Mg2+ binding site [ion binding]; other site 1323661002195 G-X-G motif; other site 1323661002196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661002197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661002198 active site 1323661002199 phosphorylation site [posttranslational modification] 1323661002200 intermolecular recognition site; other site 1323661002201 dimerization interface [polypeptide binding]; other site 1323661002202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661002203 DNA binding site [nucleotide binding] 1323661002204 Predicted membrane protein [Function unknown]; Region: COG2259 1323661002205 Electron transfer DM13; Region: DM13; pfam10517 1323661002206 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1323661002207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661002208 FeS/SAM binding site; other site 1323661002209 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1323661002210 active site 1323661002211 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1323661002212 Ligand Binding Site [chemical binding]; other site 1323661002213 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1323661002214 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1323661002215 glutamine binding [chemical binding]; other site 1323661002216 catalytic triad [active] 1323661002217 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1323661002218 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1323661002219 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1323661002220 substrate-cofactor binding pocket; other site 1323661002221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661002222 catalytic residue [active] 1323661002223 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1323661002224 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1323661002225 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1323661002226 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1323661002227 Sulfatase; Region: Sulfatase; pfam00884 1323661002228 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1323661002229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1323661002230 ABC transporter; Region: ABC_tran_2; pfam12848 1323661002231 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1323661002232 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1323661002233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661002234 ATP binding site [chemical binding]; other site 1323661002235 putative Mg++ binding site [ion binding]; other site 1323661002236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661002237 nucleotide binding region [chemical binding]; other site 1323661002238 ATP-binding site [chemical binding]; other site 1323661002239 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1323661002240 HRDC domain; Region: HRDC; pfam00570 1323661002241 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1323661002242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661002243 Walker A/P-loop; other site 1323661002244 ATP binding site [chemical binding]; other site 1323661002245 Q-loop/lid; other site 1323661002246 ABC transporter signature motif; other site 1323661002247 Walker B; other site 1323661002248 D-loop; other site 1323661002249 H-loop/switch region; other site 1323661002250 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1323661002251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661002252 dimer interface [polypeptide binding]; other site 1323661002253 conserved gate region; other site 1323661002254 ABC-ATPase subunit interface; other site 1323661002255 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1323661002256 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1323661002257 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1323661002258 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1323661002259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661002260 homodimer interface [polypeptide binding]; other site 1323661002261 catalytic residue [active] 1323661002262 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1323661002263 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1323661002264 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1323661002265 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1323661002266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661002267 putative substrate translocation pore; other site 1323661002268 POT family; Region: PTR2; cl17359 1323661002269 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1323661002270 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1323661002271 EamA-like transporter family; Region: EamA; pfam00892 1323661002272 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1323661002273 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1323661002274 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1323661002275 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1323661002276 active site 1323661002277 dimer interface [polypeptide binding]; other site 1323661002278 catalytic residues [active] 1323661002279 effector binding site; other site 1323661002280 R2 peptide binding site; other site 1323661002281 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1323661002282 dimer interface [polypeptide binding]; other site 1323661002283 putative radical transfer pathway; other site 1323661002284 diiron center [ion binding]; other site 1323661002285 tyrosyl radical; other site 1323661002286 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661002287 ABC-ATPase subunit interface; other site 1323661002288 dimer interface [polypeptide binding]; other site 1323661002289 putative PBP binding regions; other site 1323661002290 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661002291 ABC-ATPase subunit interface; other site 1323661002292 dimer interface [polypeptide binding]; other site 1323661002293 putative PBP binding regions; other site 1323661002294 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1323661002295 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1323661002296 Walker A/P-loop; other site 1323661002297 ATP binding site [chemical binding]; other site 1323661002298 Q-loop/lid; other site 1323661002299 ABC transporter signature motif; other site 1323661002300 Walker B; other site 1323661002301 D-loop; other site 1323661002302 H-loop/switch region; other site 1323661002303 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1323661002304 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1323661002305 putative ligand binding residues [chemical binding]; other site 1323661002306 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1323661002307 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1323661002308 FAD binding domain; Region: FAD_binding_4; pfam01565 1323661002309 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1323661002310 GrpB protein; Region: GrpB; pfam04229 1323661002311 NAD-dependent deacetylase; Provisional; Region: PRK14138 1323661002312 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1323661002313 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1323661002314 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1323661002315 peptidase T-like protein; Region: PepT-like; TIGR01883 1323661002316 metal binding site [ion binding]; metal-binding site 1323661002317 dimer interface [polypeptide binding]; other site 1323661002318 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1323661002319 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1323661002320 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1323661002321 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1323661002322 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1323661002323 metal binding site [ion binding]; metal-binding site 1323661002324 active site 1323661002325 I-site; other site 1323661002326 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1323661002327 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1323661002328 Mg++ binding site [ion binding]; other site 1323661002329 putative catalytic motif [active] 1323661002330 substrate binding site [chemical binding]; other site 1323661002331 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1323661002332 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1323661002333 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1323661002334 EDD domain protein, DegV family; Region: DegV; TIGR00762 1323661002335 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1323661002336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661002337 ATP binding site [chemical binding]; other site 1323661002338 putative Mg++ binding site [ion binding]; other site 1323661002339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661002340 nucleotide binding region [chemical binding]; other site 1323661002341 ATP-binding site [chemical binding]; other site 1323661002342 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1323661002343 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661002344 active site 1323661002345 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1323661002346 30S subunit binding site; other site 1323661002347 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1323661002348 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1323661002349 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1323661002350 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661002351 nucleotide binding region [chemical binding]; other site 1323661002352 ATP-binding site [chemical binding]; other site 1323661002353 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 1323661002354 SEC-C motif; Region: SEC-C; pfam02810 1323661002355 peptide chain release factor 2; Provisional; Region: PRK06746 1323661002356 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1323661002357 RF-1 domain; Region: RF-1; pfam00472 1323661002358 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1323661002359 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1323661002360 Zn2+ binding site [ion binding]; other site 1323661002361 Mg2+ binding site [ion binding]; other site 1323661002362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 1323661002363 excinuclease ABC subunit B; Provisional; Region: PRK05298 1323661002364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661002365 ATP binding site [chemical binding]; other site 1323661002366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661002367 nucleotide binding region [chemical binding]; other site 1323661002368 ATP-binding site [chemical binding]; other site 1323661002369 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1323661002370 UvrB/uvrC motif; Region: UVR; pfam02151 1323661002371 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1323661002372 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1323661002373 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1323661002374 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1323661002375 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1323661002376 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1323661002377 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1323661002378 Hpr binding site; other site 1323661002379 active site 1323661002380 homohexamer subunit interaction site [polypeptide binding]; other site 1323661002381 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1323661002382 putative acyl transferase; Provisional; Region: PRK10191 1323661002383 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1323661002384 putative trimer interface [polypeptide binding]; other site 1323661002385 putative CoA binding site [chemical binding]; other site 1323661002386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1323661002387 binding surface 1323661002388 TPR motif; other site 1323661002389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1323661002390 TPR motif; other site 1323661002391 binding surface 1323661002392 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1323661002393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661002394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661002395 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1323661002396 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1323661002397 phosphate binding site [ion binding]; other site 1323661002398 dimer interface [polypeptide binding]; other site 1323661002399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1323661002400 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1323661002401 Clp protease; Region: CLP_protease; pfam00574 1323661002402 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1323661002403 oligomer interface [polypeptide binding]; other site 1323661002404 active site residues [active] 1323661002405 malate dehydrogenase; Provisional; Region: PRK13529 1323661002406 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1323661002407 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1323661002408 NAD(P) binding pocket [chemical binding]; other site 1323661002409 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1323661002410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661002411 NAD(P) binding site [chemical binding]; other site 1323661002412 active site 1323661002413 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1323661002414 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1323661002415 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1323661002416 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1323661002417 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1323661002418 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1323661002419 substrate binding site [chemical binding]; other site 1323661002420 hinge regions; other site 1323661002421 ADP binding site [chemical binding]; other site 1323661002422 catalytic site [active] 1323661002423 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1323661002424 substrate binding site [chemical binding]; other site 1323661002425 dimer interface [polypeptide binding]; other site 1323661002426 catalytic triad [active] 1323661002427 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1323661002428 phosphoglyceromutase; Provisional; Region: PRK05434 1323661002429 enolase; Provisional; Region: eno; PRK00077 1323661002430 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1323661002431 dimer interface [polypeptide binding]; other site 1323661002432 metal binding site [ion binding]; metal-binding site 1323661002433 substrate binding pocket [chemical binding]; other site 1323661002434 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1323661002435 Esterase/lipase [General function prediction only]; Region: COG1647 1323661002436 ribonuclease R; Region: RNase_R; TIGR02063 1323661002437 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1323661002438 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1323661002439 RNB domain; Region: RNB; pfam00773 1323661002440 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1323661002441 RNA binding site [nucleotide binding]; other site 1323661002442 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1323661002443 SmpB-tmRNA interface; other site 1323661002444 Integral membrane protein DUF95; Region: DUF95; pfam01944 1323661002445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661002446 Coenzyme A binding pocket [chemical binding]; other site 1323661002447 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661002448 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1323661002449 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1323661002450 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1323661002451 Staphylococcal nuclease homologues; Region: SNc; smart00318 1323661002452 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1323661002453 Catalytic site; other site 1323661002454 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1323661002455 DNA-binding site [nucleotide binding]; DNA binding site 1323661002456 RNA-binding motif; other site 1323661002457 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1323661002458 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1323661002459 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1323661002460 catalytic core [active] 1323661002461 Lysine efflux permease [General function prediction only]; Region: COG1279 1323661002462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1323661002463 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1323661002464 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1323661002465 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1323661002466 active site 1323661002467 catalytic residue [active] 1323661002468 dimer interface [polypeptide binding]; other site 1323661002469 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1323661002470 putative FMN binding site [chemical binding]; other site 1323661002471 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1323661002472 catalytic residues [active] 1323661002473 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1323661002474 putative ArsC-like catalytic residues; other site 1323661002475 putative TRX-like catalytic residues [active] 1323661002476 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1323661002477 lipoyl attachment site [posttranslational modification]; other site 1323661002478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1323661002479 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1323661002480 putative active site [active] 1323661002481 putative metal binding site [ion binding]; other site 1323661002482 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1323661002483 catalytic residues [active] 1323661002484 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1323661002485 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1323661002486 Walker A/P-loop; other site 1323661002487 ATP binding site [chemical binding]; other site 1323661002488 Q-loop/lid; other site 1323661002489 ABC transporter signature motif; other site 1323661002490 Walker B; other site 1323661002491 D-loop; other site 1323661002492 H-loop/switch region; other site 1323661002493 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1323661002494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661002495 dimer interface [polypeptide binding]; other site 1323661002496 conserved gate region; other site 1323661002497 ABC-ATPase subunit interface; other site 1323661002498 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1323661002499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1323661002500 Predicted membrane protein [Function unknown]; Region: COG2035 1323661002501 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1323661002502 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1323661002503 Walker A/P-loop; other site 1323661002504 ATP binding site [chemical binding]; other site 1323661002505 Q-loop/lid; other site 1323661002506 ABC transporter signature motif; other site 1323661002507 Walker B; other site 1323661002508 D-loop; other site 1323661002509 H-loop/switch region; other site 1323661002510 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1323661002511 FeS assembly protein SufD; Region: sufD; TIGR01981 1323661002512 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1323661002513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1323661002514 catalytic residue [active] 1323661002515 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1323661002516 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1323661002517 trimerization site [polypeptide binding]; other site 1323661002518 active site 1323661002519 FeS assembly protein SufB; Region: sufB; TIGR01980 1323661002520 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1323661002521 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1323661002522 Domain of unknown function DUF21; Region: DUF21; pfam01595 1323661002523 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1323661002524 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1323661002525 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1323661002526 FMN binding site [chemical binding]; other site 1323661002527 substrate binding site [chemical binding]; other site 1323661002528 putative catalytic residue [active] 1323661002529 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1323661002530 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1323661002531 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1323661002532 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1323661002533 active site 1323661002534 metal binding site [ion binding]; metal-binding site 1323661002535 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1323661002536 lipoyl synthase; Provisional; Region: PRK05481 1323661002537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661002538 FeS/SAM binding site; other site 1323661002539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1323661002540 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1323661002541 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1323661002542 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1323661002543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661002544 active site 1323661002545 motif I; other site 1323661002546 motif II; other site 1323661002547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661002548 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1323661002549 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1323661002550 dimerization interface [polypeptide binding]; other site 1323661002551 ligand binding site [chemical binding]; other site 1323661002552 NADP binding site [chemical binding]; other site 1323661002553 catalytic site [active] 1323661002554 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1323661002555 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 1323661002556 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1323661002557 acyl-activating enzyme (AAE) consensus motif; other site 1323661002558 AMP binding site [chemical binding]; other site 1323661002559 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1323661002560 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1323661002561 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1323661002562 DltD N-terminal region; Region: DltD_N; pfam04915 1323661002563 DltD central region; Region: DltD_M; pfam04918 1323661002564 DltD C-terminal region; Region: DltD_C; pfam04914 1323661002565 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1323661002566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1323661002567 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1323661002568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661002569 hypothetical protein; Provisional; Region: PRK13669 1323661002570 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1323661002571 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1323661002572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661002573 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1323661002574 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1323661002575 interface (dimer of trimers) [polypeptide binding]; other site 1323661002576 Substrate-binding/catalytic site; other site 1323661002577 Zn-binding sites [ion binding]; other site 1323661002578 Predicted permease [General function prediction only]; Region: COG2056 1323661002579 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1323661002580 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1323661002581 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1323661002582 CoenzymeA binding site [chemical binding]; other site 1323661002583 subunit interaction site [polypeptide binding]; other site 1323661002584 PHB binding site; other site 1323661002585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1323661002586 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661002587 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1323661002588 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1323661002589 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 1323661002590 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1323661002591 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1323661002592 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1323661002593 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1323661002594 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1323661002595 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1323661002596 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1323661002597 Kinase associated protein B; Region: KapB; pfam08810 1323661002598 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1323661002599 active site 1323661002600 general stress protein 13; Validated; Region: PRK08059 1323661002601 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1323661002602 RNA binding site [nucleotide binding]; other site 1323661002603 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1323661002604 putative active site [active] 1323661002605 putative FMN binding site [chemical binding]; other site 1323661002606 putative substrate binding site [chemical binding]; other site 1323661002607 putative catalytic residue [active] 1323661002608 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1323661002609 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1323661002610 inhibitor-cofactor binding pocket; inhibition site 1323661002611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661002612 catalytic residue [active] 1323661002613 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1323661002614 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 1323661002615 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1323661002616 NAD(P) binding site [chemical binding]; other site 1323661002617 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1323661002618 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1323661002619 active site 1323661002620 catalytic site [active] 1323661002621 metal binding site [ion binding]; metal-binding site 1323661002622 argininosuccinate lyase; Provisional; Region: PRK00855 1323661002623 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1323661002624 active sites [active] 1323661002625 tetramer interface [polypeptide binding]; other site 1323661002626 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1323661002627 ANP binding site [chemical binding]; other site 1323661002628 Substrate Binding Site II [chemical binding]; other site 1323661002629 Substrate Binding Site I [chemical binding]; other site 1323661002630 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1323661002631 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1323661002632 active site 1323661002633 dimer interface [polypeptide binding]; other site 1323661002634 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1323661002635 dimer interface [polypeptide binding]; other site 1323661002636 active site 1323661002637 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1323661002638 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1323661002639 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1323661002640 Catalytic site [active] 1323661002641 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1323661002642 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1323661002643 Catalytic site [active] 1323661002644 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1323661002645 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1323661002646 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1323661002647 Part of AAA domain; Region: AAA_19; pfam13245 1323661002648 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1323661002649 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1323661002650 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1323661002651 hypothetical protein; Provisional; Region: PRK13673 1323661002652 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1323661002653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1323661002654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661002655 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1323661002656 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1323661002657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661002658 active site 1323661002659 motif I; other site 1323661002660 motif II; other site 1323661002661 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1323661002662 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1323661002663 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1323661002664 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1323661002665 catalytic triad [active] 1323661002666 catalytic triad [active] 1323661002667 oxyanion hole [active] 1323661002668 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1323661002669 Clp amino terminal domain; Region: Clp_N; pfam02861 1323661002670 Clp amino terminal domain; Region: Clp_N; pfam02861 1323661002671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661002672 Walker A motif; other site 1323661002673 ATP binding site [chemical binding]; other site 1323661002674 Walker B motif; other site 1323661002675 arginine finger; other site 1323661002676 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 1323661002677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661002678 Walker A motif; other site 1323661002679 ATP binding site [chemical binding]; other site 1323661002680 Walker B motif; other site 1323661002681 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1323661002682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1323661002683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1323661002684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1323661002685 dimerization interface [polypeptide binding]; other site 1323661002686 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1323661002687 substrate binding site [chemical binding]; other site 1323661002688 MAP domain; Region: MAP; pfam03642 1323661002689 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1323661002690 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1323661002691 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1323661002692 dimer interface [polypeptide binding]; other site 1323661002693 active site 1323661002694 CoA binding pocket [chemical binding]; other site 1323661002695 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1323661002696 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1323661002697 dimer interface [polypeptide binding]; other site 1323661002698 active site 1323661002699 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1323661002700 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1323661002701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661002702 dimer interface [polypeptide binding]; other site 1323661002703 conserved gate region; other site 1323661002704 putative PBP binding loops; other site 1323661002705 ABC-ATPase subunit interface; other site 1323661002706 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1323661002707 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1323661002708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661002709 dimer interface [polypeptide binding]; other site 1323661002710 conserved gate region; other site 1323661002711 putative PBP binding loops; other site 1323661002712 ABC-ATPase subunit interface; other site 1323661002713 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1323661002714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1323661002715 Walker A/P-loop; other site 1323661002716 ATP binding site [chemical binding]; other site 1323661002717 Q-loop/lid; other site 1323661002718 ABC transporter signature motif; other site 1323661002719 Walker B; other site 1323661002720 D-loop; other site 1323661002721 H-loop/switch region; other site 1323661002722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1323661002723 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1323661002724 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1323661002725 Walker A/P-loop; other site 1323661002726 ATP binding site [chemical binding]; other site 1323661002727 Q-loop/lid; other site 1323661002728 ABC transporter signature motif; other site 1323661002729 Walker B; other site 1323661002730 D-loop; other site 1323661002731 H-loop/switch region; other site 1323661002732 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1323661002733 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1323661002734 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1323661002735 peptide binding site [polypeptide binding]; other site 1323661002736 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1323661002737 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1323661002738 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1323661002739 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1323661002740 Walker A/P-loop; other site 1323661002741 ATP binding site [chemical binding]; other site 1323661002742 Q-loop/lid; other site 1323661002743 ABC transporter signature motif; other site 1323661002744 Walker B; other site 1323661002745 D-loop; other site 1323661002746 H-loop/switch region; other site 1323661002747 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1323661002748 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1323661002749 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1323661002750 Walker A/P-loop; other site 1323661002751 ATP binding site [chemical binding]; other site 1323661002752 Q-loop/lid; other site 1323661002753 ABC transporter signature motif; other site 1323661002754 Walker B; other site 1323661002755 D-loop; other site 1323661002756 H-loop/switch region; other site 1323661002757 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1323661002758 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1323661002759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661002760 dimer interface [polypeptide binding]; other site 1323661002761 conserved gate region; other site 1323661002762 putative PBP binding loops; other site 1323661002763 ABC-ATPase subunit interface; other site 1323661002764 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1323661002765 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1323661002766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661002767 dimer interface [polypeptide binding]; other site 1323661002768 conserved gate region; other site 1323661002769 putative PBP binding loops; other site 1323661002770 ABC-ATPase subunit interface; other site 1323661002771 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 1323661002772 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1323661002773 active site 1323661002774 HIGH motif; other site 1323661002775 dimer interface [polypeptide binding]; other site 1323661002776 KMSKS motif; other site 1323661002777 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1323661002778 putative catalytic residues [active] 1323661002779 thiol/disulfide switch; other site 1323661002780 adaptor protein; Provisional; Region: PRK02315 1323661002781 Competence protein CoiA-like family; Region: CoiA; cl11541 1323661002782 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1323661002783 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1323661002784 active site 1323661002785 Zn binding site [ion binding]; other site 1323661002786 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1323661002787 Thioredoxin; Region: Thioredoxin_5; pfam13743 1323661002788 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1323661002789 apolar tunnel; other site 1323661002790 heme binding site [chemical binding]; other site 1323661002791 dimerization interface [polypeptide binding]; other site 1323661002792 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1323661002793 putative active site [active] 1323661002794 putative metal binding residues [ion binding]; other site 1323661002795 signature motif; other site 1323661002796 putative triphosphate binding site [ion binding]; other site 1323661002797 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1323661002798 synthetase active site [active] 1323661002799 NTP binding site [chemical binding]; other site 1323661002800 metal binding site [ion binding]; metal-binding site 1323661002801 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1323661002802 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1323661002803 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1323661002804 active site 1323661002805 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1323661002806 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1323661002807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1323661002808 Divalent cation transporter; Region: MgtE; pfam01769 1323661002809 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1323661002810 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1323661002811 TrkA-N domain; Region: TrkA_N; pfam02254 1323661002812 TrkA-C domain; Region: TrkA_C; pfam02080 1323661002813 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1323661002814 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1323661002815 NAD binding site [chemical binding]; other site 1323661002816 homotetramer interface [polypeptide binding]; other site 1323661002817 homodimer interface [polypeptide binding]; other site 1323661002818 substrate binding site [chemical binding]; other site 1323661002819 active site 1323661002820 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1323661002821 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1323661002822 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1323661002823 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 1323661002824 Putative esterase; Region: Esterase; pfam00756 1323661002825 hypothetical protein; Provisional; Region: PRK13679 1323661002826 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1323661002827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661002828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661002829 putative substrate translocation pore; other site 1323661002830 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1323661002831 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1323661002832 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1323661002833 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1323661002834 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1323661002835 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1323661002836 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1323661002837 YueH-like protein; Region: YueH; pfam14166 1323661002838 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1323661002839 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1323661002840 G1 box; other site 1323661002841 putative GEF interaction site [polypeptide binding]; other site 1323661002842 GTP/Mg2+ binding site [chemical binding]; other site 1323661002843 Switch I region; other site 1323661002844 G2 box; other site 1323661002845 G3 box; other site 1323661002846 Switch II region; other site 1323661002847 G4 box; other site 1323661002848 G5 box; other site 1323661002849 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1323661002850 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1323661002851 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1323661002852 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1323661002853 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1323661002854 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1323661002855 protein binding site [polypeptide binding]; other site 1323661002856 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1323661002857 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1323661002858 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1323661002859 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1323661002860 active site 1323661002861 metal binding site [ion binding]; metal-binding site 1323661002862 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1323661002863 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1323661002864 IDEAL domain; Region: IDEAL; pfam08858 1323661002865 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1323661002866 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1323661002867 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1323661002868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1323661002869 CAAX protease self-immunity; Region: Abi; pfam02517 1323661002870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1323661002871 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1323661002872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1323661002873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661002874 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1323661002875 Walker A/P-loop; other site 1323661002876 ATP binding site [chemical binding]; other site 1323661002877 Q-loop/lid; other site 1323661002878 ABC transporter signature motif; other site 1323661002879 Walker B; other site 1323661002880 D-loop; other site 1323661002881 H-loop/switch region; other site 1323661002882 Predicted membrane protein [Function unknown]; Region: COG2259 1323661002883 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1323661002884 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1323661002885 siderophore binding site; other site 1323661002886 TM2 domain; Region: TM2; cl00984 1323661002887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661002888 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1323661002889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1323661002890 Coenzyme A binding pocket [chemical binding]; other site 1323661002891 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 1323661002892 putative active site [active] 1323661002893 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1323661002894 isochorismate synthases; Region: isochor_syn; TIGR00543 1323661002895 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1323661002896 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1323661002897 dimer interface [polypeptide binding]; other site 1323661002898 tetramer interface [polypeptide binding]; other site 1323661002899 PYR/PP interface [polypeptide binding]; other site 1323661002900 TPP binding site [chemical binding]; other site 1323661002901 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1323661002902 TPP-binding site; other site 1323661002903 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1323661002904 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1323661002905 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1323661002906 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1323661002907 substrate binding site [chemical binding]; other site 1323661002908 oxyanion hole (OAH) forming residues; other site 1323661002909 trimer interface [polypeptide binding]; other site 1323661002910 Staphostatin B; Region: Staphostatin_B; pfam09023 1323661002911 Staphopain proregion; Region: Staphopain_pro; pfam14731 1323661002912 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1323661002913 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1323661002914 aminotransferase A; Validated; Region: PRK07683 1323661002915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1323661002916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661002917 homodimer interface [polypeptide binding]; other site 1323661002918 catalytic residue [active] 1323661002919 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1323661002920 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661002921 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1323661002922 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1323661002923 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1323661002924 amidase catalytic site [active] 1323661002925 Zn binding residues [ion binding]; other site 1323661002926 substrate binding site [chemical binding]; other site 1323661002927 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1323661002928 Lysozyme subfamily 2; Region: LYZ2; smart00047 1323661002929 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1323661002930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661002931 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1323661002932 Coenzyme A binding pocket [chemical binding]; other site 1323661002933 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1323661002934 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1323661002935 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1323661002936 Beta-lactamase; Region: Beta-lactamase; pfam00144 1323661002937 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1323661002938 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1323661002939 Subunit I/III interface [polypeptide binding]; other site 1323661002940 Subunit III/IV interface [polypeptide binding]; other site 1323661002941 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1323661002942 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1323661002943 D-pathway; other site 1323661002944 Putative ubiquinol binding site [chemical binding]; other site 1323661002945 Low-spin heme (heme b) binding site [chemical binding]; other site 1323661002946 Putative water exit pathway; other site 1323661002947 Binuclear center (heme o3/CuB) [ion binding]; other site 1323661002948 K-pathway; other site 1323661002949 Putative proton exit pathway; other site 1323661002950 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1323661002951 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1323661002952 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1323661002953 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1323661002954 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1323661002955 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1323661002956 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1323661002957 homodimer interface [polypeptide binding]; other site 1323661002958 NADP binding site [chemical binding]; other site 1323661002959 substrate binding site [chemical binding]; other site 1323661002960 AIR carboxylase; Region: AIRC; cl00310 1323661002961 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1323661002962 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1323661002963 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1323661002964 ATP binding site [chemical binding]; other site 1323661002965 active site 1323661002966 substrate binding site [chemical binding]; other site 1323661002967 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1323661002968 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1323661002969 putative active site [active] 1323661002970 catalytic triad [active] 1323661002971 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1323661002972 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1323661002973 dimerization interface [polypeptide binding]; other site 1323661002974 ATP binding site [chemical binding]; other site 1323661002975 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1323661002976 dimerization interface [polypeptide binding]; other site 1323661002977 ATP binding site [chemical binding]; other site 1323661002978 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1323661002979 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1323661002980 active site 1323661002981 tetramer interface [polypeptide binding]; other site 1323661002982 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661002983 active site 1323661002984 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1323661002985 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1323661002986 dimerization interface [polypeptide binding]; other site 1323661002987 putative ATP binding site [chemical binding]; other site 1323661002988 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1323661002989 active site 1323661002990 substrate binding site [chemical binding]; other site 1323661002991 cosubstrate binding site; other site 1323661002992 catalytic site [active] 1323661002993 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1323661002994 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1323661002995 purine monophosphate binding site [chemical binding]; other site 1323661002996 dimer interface [polypeptide binding]; other site 1323661002997 putative catalytic residues [active] 1323661002998 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1323661002999 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1323661003000 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1323661003001 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1323661003002 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1323661003003 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1323661003004 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1323661003005 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1323661003006 Walker A/P-loop; other site 1323661003007 ATP binding site [chemical binding]; other site 1323661003008 Q-loop/lid; other site 1323661003009 ABC transporter signature motif; other site 1323661003010 Walker B; other site 1323661003011 D-loop; other site 1323661003012 H-loop/switch region; other site 1323661003013 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1323661003014 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1323661003015 Walker A/P-loop; other site 1323661003016 ATP binding site [chemical binding]; other site 1323661003017 Q-loop/lid; other site 1323661003018 ABC transporter signature motif; other site 1323661003019 Walker B; other site 1323661003020 D-loop; other site 1323661003021 H-loop/switch region; other site 1323661003022 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1323661003023 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1323661003024 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1323661003025 putative RNA binding site [nucleotide binding]; other site 1323661003026 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1323661003027 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1323661003028 dimerization domain swap beta strand [polypeptide binding]; other site 1323661003029 regulatory protein interface [polypeptide binding]; other site 1323661003030 active site 1323661003031 regulatory phosphorylation site [posttranslational modification]; other site 1323661003032 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1323661003033 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 1323661003034 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1323661003035 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1323661003036 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1323661003037 catalytic residues [active] 1323661003038 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1323661003039 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1323661003040 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 1323661003041 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1323661003042 TrkA-N domain; Region: TrkA_N; pfam02254 1323661003043 TrkA-C domain; Region: TrkA_C; pfam02080 1323661003044 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1323661003045 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1323661003046 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 1323661003047 hypothetical protein; Provisional; Region: PRK13667 1323661003048 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1323661003049 active site 1323661003050 catalytic residues [active] 1323661003051 metal binding site [ion binding]; metal-binding site 1323661003052 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1323661003053 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1323661003054 TPP-binding site [chemical binding]; other site 1323661003055 tetramer interface [polypeptide binding]; other site 1323661003056 heterodimer interface [polypeptide binding]; other site 1323661003057 phosphorylation loop region [posttranslational modification] 1323661003058 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1323661003059 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1323661003060 alpha subunit interface [polypeptide binding]; other site 1323661003061 TPP binding site [chemical binding]; other site 1323661003062 heterodimer interface [polypeptide binding]; other site 1323661003063 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1323661003064 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1323661003065 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1323661003066 E3 interaction surface; other site 1323661003067 lipoyl attachment site [posttranslational modification]; other site 1323661003068 e3 binding domain; Region: E3_binding; pfam02817 1323661003069 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1323661003070 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1323661003071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661003072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661003073 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1323661003074 hypothetical protein; Provisional; Region: PRK04387 1323661003075 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1323661003076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661003077 non-specific DNA binding site [nucleotide binding]; other site 1323661003078 salt bridge; other site 1323661003079 sequence-specific DNA binding site [nucleotide binding]; other site 1323661003080 Cupin domain; Region: Cupin_2; pfam07883 1323661003081 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1323661003082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661003083 Walker A/P-loop; other site 1323661003084 ATP binding site [chemical binding]; other site 1323661003085 Q-loop/lid; other site 1323661003086 ABC transporter signature motif; other site 1323661003087 Walker B; other site 1323661003088 D-loop; other site 1323661003089 H-loop/switch region; other site 1323661003090 TOBE domain; Region: TOBE_2; pfam08402 1323661003091 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1323661003092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661003093 dimer interface [polypeptide binding]; other site 1323661003094 conserved gate region; other site 1323661003095 putative PBP binding loops; other site 1323661003096 ABC-ATPase subunit interface; other site 1323661003097 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1323661003098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661003099 dimer interface [polypeptide binding]; other site 1323661003100 conserved gate region; other site 1323661003101 putative PBP binding loops; other site 1323661003102 ABC-ATPase subunit interface; other site 1323661003103 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1323661003104 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1323661003105 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1323661003106 manganese transport protein MntH; Reviewed; Region: PRK00701 1323661003107 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1323661003108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1323661003109 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1323661003110 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1323661003111 active site 1323661003112 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1323661003113 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1323661003114 G1 box; other site 1323661003115 putative GEF interaction site [polypeptide binding]; other site 1323661003116 GTP/Mg2+ binding site [chemical binding]; other site 1323661003117 Switch I region; other site 1323661003118 G2 box; other site 1323661003119 G3 box; other site 1323661003120 Switch II region; other site 1323661003121 G4 box; other site 1323661003122 G5 box; other site 1323661003123 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1323661003124 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1323661003125 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1323661003126 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1323661003127 hypothetical protein; Provisional; Region: PRK13666 1323661003128 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1323661003129 pyruvate carboxylase; Reviewed; Region: PRK12999 1323661003130 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1323661003131 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1323661003132 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1323661003133 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1323661003134 active site 1323661003135 catalytic residues [active] 1323661003136 metal binding site [ion binding]; metal-binding site 1323661003137 homodimer binding site [polypeptide binding]; other site 1323661003138 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 1323661003139 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1323661003140 carboxyltransferase (CT) interaction site; other site 1323661003141 biotinylation site [posttranslational modification]; other site 1323661003142 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1323661003143 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 1323661003144 putative active site [active] 1323661003145 Predicted membrane protein [Function unknown]; Region: COG2322 1323661003146 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 1323661003147 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1323661003148 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1323661003149 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1323661003150 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1323661003151 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1323661003152 putative active site [active] 1323661003153 catalytic site [active] 1323661003154 putative metal binding site [ion binding]; other site 1323661003155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1323661003156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661003157 S-adenosylmethionine binding site [chemical binding]; other site 1323661003158 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1323661003159 active site 1323661003160 (T/H)XGH motif; other site 1323661003161 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1323661003162 hypothetical protein; Provisional; Region: PRK13670 1323661003163 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1323661003164 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1323661003165 heme uptake protein IsdB; Region: IsdB; TIGR03657 1323661003166 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661003167 NEAr Transporter domain; Region: NEAT; smart00725 1323661003168 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1323661003169 heme-binding site [chemical binding]; other site 1323661003170 Protein of unknown function (DUF1675); Region: DUF1675; pfam07897 1323661003171 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1323661003172 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1323661003173 heme-binding site [chemical binding]; other site 1323661003174 heme uptake protein IsdC; Region: IsdC; TIGR03656 1323661003175 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1323661003176 heme-binding site [chemical binding]; other site 1323661003177 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1323661003178 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1323661003179 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1323661003180 intersubunit interface [polypeptide binding]; other site 1323661003181 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661003182 ABC-ATPase subunit interface; other site 1323661003183 dimer interface [polypeptide binding]; other site 1323661003184 putative PBP binding regions; other site 1323661003185 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1323661003186 active site 1323661003187 catalytic site [active] 1323661003188 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 1323661003189 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1323661003190 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1323661003191 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1323661003192 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1323661003193 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1323661003194 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1323661003195 dimer interface [polypeptide binding]; other site 1323661003196 motif 1; other site 1323661003197 active site 1323661003198 motif 2; other site 1323661003199 motif 3; other site 1323661003200 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1323661003201 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1323661003202 putative tRNA-binding site [nucleotide binding]; other site 1323661003203 B3/4 domain; Region: B3_4; pfam03483 1323661003204 tRNA synthetase B5 domain; Region: B5; smart00874 1323661003205 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1323661003206 dimer interface [polypeptide binding]; other site 1323661003207 motif 1; other site 1323661003208 motif 3; other site 1323661003209 motif 2; other site 1323661003210 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1323661003211 ribonuclease HIII; Provisional; Region: PRK00996 1323661003212 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1323661003213 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1323661003214 RNA/DNA hybrid binding site [nucleotide binding]; other site 1323661003215 active site 1323661003216 Cell division protein ZapA; Region: ZapA; cl01146 1323661003217 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1323661003218 hypothetical protein; Provisional; Region: PRK08609 1323661003219 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1323661003220 active site 1323661003221 primer binding site [nucleotide binding]; other site 1323661003222 NTP binding site [chemical binding]; other site 1323661003223 metal binding triad [ion binding]; metal-binding site 1323661003224 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1323661003225 active site 1323661003226 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1323661003227 MutS domain III; Region: MutS_III; pfam05192 1323661003228 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1323661003229 Walker A/P-loop; other site 1323661003230 ATP binding site [chemical binding]; other site 1323661003231 Q-loop/lid; other site 1323661003232 ABC transporter signature motif; other site 1323661003233 Walker B; other site 1323661003234 D-loop; other site 1323661003235 H-loop/switch region; other site 1323661003236 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 1323661003237 Smr domain; Region: Smr; pfam01713 1323661003238 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1323661003239 catalytic residues [active] 1323661003240 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1323661003241 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1323661003242 GIY-YIG motif/motif A; other site 1323661003243 active site 1323661003244 catalytic site [active] 1323661003245 putative DNA binding site [nucleotide binding]; other site 1323661003246 metal binding site [ion binding]; metal-binding site 1323661003247 UvrB/uvrC motif; Region: UVR; pfam02151 1323661003248 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1323661003249 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 1323661003250 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1323661003251 putative Iron-sulfur protein interface [polypeptide binding]; other site 1323661003252 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1323661003253 proximal heme binding site [chemical binding]; other site 1323661003254 distal heme binding site [chemical binding]; other site 1323661003255 putative dimer interface [polypeptide binding]; other site 1323661003256 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1323661003257 L-aspartate oxidase; Provisional; Region: PRK06175 1323661003258 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1323661003259 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1323661003260 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1323661003261 glutamate racemase; Provisional; Region: PRK00865 1323661003262 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1323661003263 active site 1323661003264 dimerization interface [polypeptide binding]; other site 1323661003265 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1323661003266 active site 1323661003267 metal binding site [ion binding]; metal-binding site 1323661003268 homotetramer interface [polypeptide binding]; other site 1323661003269 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1323661003270 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 1323661003271 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1323661003272 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1323661003273 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1323661003274 superantigen-like protein; Reviewed; Region: PRK13350 1323661003275 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661003276 superantigen-like protein; Reviewed; Region: PRK13349 1323661003277 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661003278 superantigen-like protein; Reviewed; Region: PRK13043 1323661003279 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661003280 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1323661003281 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1323661003282 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1323661003283 carbamate kinase; Reviewed; Region: PRK12686 1323661003284 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1323661003285 putative substrate binding site [chemical binding]; other site 1323661003286 nucleotide binding site [chemical binding]; other site 1323661003287 nucleotide binding site [chemical binding]; other site 1323661003288 homodimer interface [polypeptide binding]; other site 1323661003289 Predicted membrane protein [Function unknown]; Region: COG1288 1323661003290 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1323661003291 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1323661003292 gating phenylalanine in ion channel; other site 1323661003293 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1323661003294 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1323661003295 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1323661003296 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1323661003297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661003298 motif II; other site 1323661003299 hypothetical protein; Provisional; Region: PRK13688 1323661003300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1323661003301 Coenzyme A binding pocket [chemical binding]; other site 1323661003302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1323661003303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1323661003304 MraZ protein; Region: MraZ; pfam02381 1323661003305 MraZ protein; Region: MraZ; pfam02381 1323661003306 MraW methylase family; Region: Methyltransf_5; pfam01795 1323661003307 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1323661003308 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1323661003309 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 1323661003310 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1323661003311 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1323661003312 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1323661003313 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1323661003314 Mg++ binding site [ion binding]; other site 1323661003315 putative catalytic motif [active] 1323661003316 putative substrate binding site [chemical binding]; other site 1323661003317 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1323661003318 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1323661003319 NAD binding site [chemical binding]; other site 1323661003320 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1323661003321 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1323661003322 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1323661003323 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1323661003324 Cell division protein FtsQ; Region: FtsQ; pfam03799 1323661003325 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1323661003326 Cell division protein FtsA; Region: FtsA; smart00842 1323661003327 Cell division protein FtsA; Region: FtsA; pfam14450 1323661003328 cell division protein FtsZ; Validated; Region: PRK09330 1323661003329 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1323661003330 nucleotide binding site [chemical binding]; other site 1323661003331 SulA interaction site; other site 1323661003332 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1323661003333 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1323661003334 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1323661003335 catalytic residue [active] 1323661003336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1323661003337 Predicted integral membrane protein [Function unknown]; Region: COG0762 1323661003338 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1323661003339 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1323661003340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1323661003341 RNA binding surface [nucleotide binding]; other site 1323661003342 DivIVA protein; Region: DivIVA; pfam05103 1323661003343 DivIVA domain; Region: DivI1A_domain; TIGR03544 1323661003344 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1323661003345 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1323661003346 active site 1323661003347 HIGH motif; other site 1323661003348 KMSKS motif; other site 1323661003349 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1323661003350 tRNA binding surface [nucleotide binding]; other site 1323661003351 anticodon binding site; other site 1323661003352 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1323661003353 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1323661003354 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1323661003355 active site 1323661003356 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1323661003357 lipoprotein signal peptidase; Provisional; Region: PRK14787 1323661003358 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1323661003359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1323661003360 RNA binding surface [nucleotide binding]; other site 1323661003361 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1323661003362 active site 1323661003363 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661003364 active site 1323661003365 uracil transporter; Provisional; Region: PRK10720 1323661003366 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1323661003367 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1323661003368 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1323661003369 dihydroorotase; Validated; Region: pyrC; PRK09357 1323661003370 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1323661003371 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1323661003372 active site 1323661003373 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1323661003374 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1323661003375 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1323661003376 catalytic site [active] 1323661003377 subunit interface [polypeptide binding]; other site 1323661003378 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1323661003379 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1323661003380 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1323661003381 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 1323661003382 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1323661003383 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1323661003384 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1323661003385 IMP binding site; other site 1323661003386 dimer interface [polypeptide binding]; other site 1323661003387 interdomain contacts; other site 1323661003388 partial ornithine binding site; other site 1323661003389 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1323661003390 active site 1323661003391 dimer interface [polypeptide binding]; other site 1323661003392 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661003393 active site 1323661003394 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1323661003395 dimer interface [polypeptide binding]; other site 1323661003396 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1323661003397 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 1323661003398 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1323661003399 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1323661003400 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1323661003401 catalytic site [active] 1323661003402 G-X2-G-X-G-K; other site 1323661003403 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1323661003404 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1323661003405 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 1323661003406 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 1323661003407 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1323661003408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661003409 ATP binding site [chemical binding]; other site 1323661003410 putative Mg++ binding site [ion binding]; other site 1323661003411 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1323661003412 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1323661003413 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1323661003414 active site 1323661003415 catalytic residues [active] 1323661003416 metal binding site [ion binding]; metal-binding site 1323661003417 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1323661003418 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1323661003419 putative active site [active] 1323661003420 substrate binding site [chemical binding]; other site 1323661003421 putative cosubstrate binding site; other site 1323661003422 catalytic site [active] 1323661003423 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1323661003424 substrate binding site [chemical binding]; other site 1323661003425 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1323661003426 NusB family; Region: NusB; pfam01029 1323661003427 putative RNA binding site [nucleotide binding]; other site 1323661003428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661003429 S-adenosylmethionine binding site [chemical binding]; other site 1323661003430 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1323661003431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661003432 FeS/SAM binding site; other site 1323661003433 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1323661003434 active site 1323661003435 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1323661003436 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1323661003437 active site 1323661003438 ATP binding site [chemical binding]; other site 1323661003439 substrate binding site [chemical binding]; other site 1323661003440 activation loop (A-loop); other site 1323661003441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1323661003442 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1323661003443 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1323661003444 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1323661003445 Predicted GTPases [General function prediction only]; Region: COG1162 1323661003446 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1323661003447 RNA binding site [nucleotide binding]; other site 1323661003448 homodimer interface [polypeptide binding]; other site 1323661003449 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1323661003450 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1323661003451 GTP/Mg2+ binding site [chemical binding]; other site 1323661003452 G4 box; other site 1323661003453 G5 box; other site 1323661003454 G1 box; other site 1323661003455 Switch I region; other site 1323661003456 G2 box; other site 1323661003457 G3 box; other site 1323661003458 Switch II region; other site 1323661003459 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1323661003460 substrate binding site [chemical binding]; other site 1323661003461 hexamer interface [polypeptide binding]; other site 1323661003462 metal binding site [ion binding]; metal-binding site 1323661003463 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1323661003464 Thiamine pyrophosphokinase; Region: TPK; cd07995 1323661003465 active site 1323661003466 dimerization interface [polypeptide binding]; other site 1323661003467 thiamine binding site [chemical binding]; other site 1323661003468 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1323661003469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1323661003470 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1323661003471 DAK2 domain; Region: Dak2; pfam02734 1323661003472 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1323661003473 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1323661003474 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1323661003475 generic binding surface II; other site 1323661003476 ssDNA binding site; other site 1323661003477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661003478 ATP binding site [chemical binding]; other site 1323661003479 putative Mg++ binding site [ion binding]; other site 1323661003480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661003481 nucleotide binding region [chemical binding]; other site 1323661003482 ATP-binding site [chemical binding]; other site 1323661003483 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1323661003484 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1323661003485 active site 2 [active] 1323661003486 active site 1 [active] 1323661003487 putative phosphate acyltransferase; Provisional; Region: PRK05331 1323661003488 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1323661003489 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1323661003490 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1323661003491 NAD(P) binding site [chemical binding]; other site 1323661003492 homotetramer interface [polypeptide binding]; other site 1323661003493 homodimer interface [polypeptide binding]; other site 1323661003494 active site 1323661003495 acyl carrier protein; Provisional; Region: acpP; PRK00982 1323661003496 ribonuclease III; Reviewed; Region: rnc; PRK00102 1323661003497 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1323661003498 dimerization interface [polypeptide binding]; other site 1323661003499 active site 1323661003500 metal binding site [ion binding]; metal-binding site 1323661003501 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1323661003502 dsRNA binding site [nucleotide binding]; other site 1323661003503 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1323661003504 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1323661003505 Walker A/P-loop; other site 1323661003506 ATP binding site [chemical binding]; other site 1323661003507 Q-loop/lid; other site 1323661003508 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1323661003509 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1323661003510 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1323661003511 ABC transporter signature motif; other site 1323661003512 Walker B; other site 1323661003513 D-loop; other site 1323661003514 H-loop/switch region; other site 1323661003515 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1323661003516 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1323661003517 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1323661003518 P loop; other site 1323661003519 GTP binding site [chemical binding]; other site 1323661003520 putative DNA-binding protein; Validated; Region: PRK00118 1323661003521 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1323661003522 signal recognition particle protein; Provisional; Region: PRK10867 1323661003523 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1323661003524 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1323661003525 P loop; other site 1323661003526 GTP binding site [chemical binding]; other site 1323661003527 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1323661003528 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1323661003529 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1323661003530 RimM N-terminal domain; Region: RimM; pfam01782 1323661003531 PRC-barrel domain; Region: PRC; pfam05239 1323661003532 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1323661003533 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1323661003534 Predicted membrane protein [Function unknown]; Region: COG4485 1323661003535 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1323661003536 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1323661003537 GTP/Mg2+ binding site [chemical binding]; other site 1323661003538 G4 box; other site 1323661003539 G5 box; other site 1323661003540 G1 box; other site 1323661003541 Switch I region; other site 1323661003542 G2 box; other site 1323661003543 G3 box; other site 1323661003544 Switch II region; other site 1323661003545 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1323661003546 RNA/DNA hybrid binding site [nucleotide binding]; other site 1323661003547 active site 1323661003548 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1323661003549 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1323661003550 CoA-ligase; Region: Ligase_CoA; pfam00549 1323661003551 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1323661003552 CoA binding domain; Region: CoA_binding; pfam02629 1323661003553 CoA-ligase; Region: Ligase_CoA; pfam00549 1323661003554 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 1323661003555 CHAP domain; Region: CHAP; pfam05257 1323661003556 FemAB family; Region: FemAB; pfam02388 1323661003557 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1323661003558 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1323661003559 DNA topoisomerase I; Validated; Region: PRK05582 1323661003560 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1323661003561 active site 1323661003562 interdomain interaction site; other site 1323661003563 putative metal-binding site [ion binding]; other site 1323661003564 nucleotide binding site [chemical binding]; other site 1323661003565 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1323661003566 domain I; other site 1323661003567 DNA binding groove [nucleotide binding] 1323661003568 phosphate binding site [ion binding]; other site 1323661003569 domain II; other site 1323661003570 domain III; other site 1323661003571 nucleotide binding site [chemical binding]; other site 1323661003572 catalytic site [active] 1323661003573 domain IV; other site 1323661003574 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1323661003575 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1323661003576 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1323661003577 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1323661003578 Glucose inhibited division protein A; Region: GIDA; pfam01134 1323661003579 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1323661003580 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1323661003581 active site 1323661003582 DNA binding site [nucleotide binding] 1323661003583 Int/Topo IB signature motif; other site 1323661003584 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1323661003585 active site 1323661003586 HslU subunit interaction site [polypeptide binding]; other site 1323661003587 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1323661003588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661003589 Walker A motif; other site 1323661003590 ATP binding site [chemical binding]; other site 1323661003591 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1323661003592 Walker B motif; other site 1323661003593 arginine finger; other site 1323661003594 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1323661003595 transcriptional repressor CodY; Validated; Region: PRK04158 1323661003596 CodY GAF-like domain; Region: CodY; pfam06018 1323661003597 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1323661003598 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1323661003599 rRNA interaction site [nucleotide binding]; other site 1323661003600 S8 interaction site; other site 1323661003601 putative laminin-1 binding site; other site 1323661003602 elongation factor Ts; Provisional; Region: tsf; PRK09377 1323661003603 UBA/TS-N domain; Region: UBA; pfam00627 1323661003604 Elongation factor TS; Region: EF_TS; pfam00889 1323661003605 Elongation factor TS; Region: EF_TS; pfam00889 1323661003606 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1323661003607 putative nucleotide binding site [chemical binding]; other site 1323661003608 uridine monophosphate binding site [chemical binding]; other site 1323661003609 homohexameric interface [polypeptide binding]; other site 1323661003610 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1323661003611 hinge region; other site 1323661003612 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1323661003613 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1323661003614 catalytic residue [active] 1323661003615 putative FPP diphosphate binding site; other site 1323661003616 putative FPP binding hydrophobic cleft; other site 1323661003617 dimer interface [polypeptide binding]; other site 1323661003618 putative IPP diphosphate binding site; other site 1323661003619 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1323661003620 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1323661003621 RIP metalloprotease RseP; Region: TIGR00054 1323661003622 active site 1323661003623 putative substrate binding region [chemical binding]; other site 1323661003624 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1323661003625 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1323661003626 dimer interface [polypeptide binding]; other site 1323661003627 motif 1; other site 1323661003628 active site 1323661003629 motif 2; other site 1323661003630 motif 3; other site 1323661003631 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1323661003632 anticodon binding site; other site 1323661003633 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1323661003634 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 1323661003635 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 1323661003636 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1323661003637 generic binding surface II; other site 1323661003638 generic binding surface I; other site 1323661003639 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1323661003640 active site 1323661003641 putative PHP Thumb interface [polypeptide binding]; other site 1323661003642 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1323661003643 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 1323661003644 Sm and related proteins; Region: Sm_like; cl00259 1323661003645 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1323661003646 putative oligomer interface [polypeptide binding]; other site 1323661003647 putative RNA binding site [nucleotide binding]; other site 1323661003648 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1323661003649 NusA N-terminal domain; Region: NusA_N; pfam08529 1323661003650 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1323661003651 RNA binding site [nucleotide binding]; other site 1323661003652 homodimer interface [polypeptide binding]; other site 1323661003653 NusA-like KH domain; Region: KH_5; pfam13184 1323661003654 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1323661003655 G-X-X-G motif; other site 1323661003656 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1323661003657 putative RNA binding cleft [nucleotide binding]; other site 1323661003658 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1323661003659 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1323661003660 translation initiation factor IF-2; Region: IF-2; TIGR00487 1323661003661 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1323661003662 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1323661003663 G1 box; other site 1323661003664 putative GEF interaction site [polypeptide binding]; other site 1323661003665 GTP/Mg2+ binding site [chemical binding]; other site 1323661003666 Switch I region; other site 1323661003667 G2 box; other site 1323661003668 G3 box; other site 1323661003669 Switch II region; other site 1323661003670 G4 box; other site 1323661003671 G5 box; other site 1323661003672 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1323661003673 Translation-initiation factor 2; Region: IF-2; pfam11987 1323661003674 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1323661003675 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1323661003676 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1323661003677 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1323661003678 RNA binding site [nucleotide binding]; other site 1323661003679 active site 1323661003680 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1323661003681 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1323661003682 active site 1323661003683 Riboflavin kinase; Region: Flavokinase; smart00904 1323661003684 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1323661003685 16S/18S rRNA binding site [nucleotide binding]; other site 1323661003686 S13e-L30e interaction site [polypeptide binding]; other site 1323661003687 25S rRNA binding site [nucleotide binding]; other site 1323661003688 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1323661003689 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1323661003690 RNase E interface [polypeptide binding]; other site 1323661003691 trimer interface [polypeptide binding]; other site 1323661003692 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1323661003693 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1323661003694 RNase E interface [polypeptide binding]; other site 1323661003695 trimer interface [polypeptide binding]; other site 1323661003696 active site 1323661003697 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1323661003698 putative nucleic acid binding region [nucleotide binding]; other site 1323661003699 G-X-X-G motif; other site 1323661003700 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1323661003701 RNA binding site [nucleotide binding]; other site 1323661003702 domain interface; other site 1323661003703 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1323661003704 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1323661003705 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 1323661003706 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1323661003707 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1323661003708 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1323661003709 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1323661003710 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1323661003711 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1323661003712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1323661003713 DNA-binding site [nucleotide binding]; DNA binding site 1323661003714 UTRA domain; Region: UTRA; pfam07702 1323661003715 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1323661003716 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1323661003717 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1323661003718 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1323661003719 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1323661003720 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1323661003721 classical (c) SDRs; Region: SDR_c; cd05233 1323661003722 NAD(P) binding site [chemical binding]; other site 1323661003723 active site 1323661003724 ACT domain; Region: ACT; pfam01842 1323661003725 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1323661003726 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1323661003727 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661003728 non-specific DNA binding site [nucleotide binding]; other site 1323661003729 salt bridge; other site 1323661003730 sequence-specific DNA binding site [nucleotide binding]; other site 1323661003731 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1323661003732 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1323661003733 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1323661003734 putative MPT binding site; other site 1323661003735 recombinase A; Provisional; Region: recA; PRK09354 1323661003736 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1323661003737 hexamer interface [polypeptide binding]; other site 1323661003738 Walker A motif; other site 1323661003739 ATP binding site [chemical binding]; other site 1323661003740 Walker B motif; other site 1323661003741 phosphodiesterase; Provisional; Region: PRK12704 1323661003742 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1323661003743 Zn2+ binding site [ion binding]; other site 1323661003744 Mg2+ binding site [ion binding]; other site 1323661003745 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1323661003746 putative active site [active] 1323661003747 metal binding site [ion binding]; metal-binding site 1323661003748 homodimer binding site [polypeptide binding]; other site 1323661003749 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1323661003750 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1323661003751 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1323661003752 dimer interface [polypeptide binding]; other site 1323661003753 PYR/PP interface [polypeptide binding]; other site 1323661003754 TPP binding site [chemical binding]; other site 1323661003755 substrate binding site [chemical binding]; other site 1323661003756 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1323661003757 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1323661003758 TPP-binding site [chemical binding]; other site 1323661003759 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1323661003760 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1323661003761 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1323661003762 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1323661003763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661003764 FeS/SAM binding site; other site 1323661003765 TRAM domain; Region: TRAM; pfam01938 1323661003766 Predicted membrane protein [Function unknown]; Region: COG4550 1323661003767 Predicted membrane protein [Function unknown]; Region: COG4732 1323661003768 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1323661003769 MutS domain I; Region: MutS_I; pfam01624 1323661003770 MutS domain II; Region: MutS_II; pfam05188 1323661003771 MutS domain III; Region: MutS_III; pfam05192 1323661003772 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1323661003773 Walker A/P-loop; other site 1323661003774 ATP binding site [chemical binding]; other site 1323661003775 Q-loop/lid; other site 1323661003776 ABC transporter signature motif; other site 1323661003777 Walker B; other site 1323661003778 D-loop; other site 1323661003779 H-loop/switch region; other site 1323661003780 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1323661003781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661003782 ATP binding site [chemical binding]; other site 1323661003783 Mg2+ binding site [ion binding]; other site 1323661003784 G-X-G motif; other site 1323661003785 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1323661003786 ATP binding site [chemical binding]; other site 1323661003787 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 1323661003788 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 1323661003789 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1323661003790 amphipathic channel; other site 1323661003791 Asn-Pro-Ala signature motifs; other site 1323661003792 glycerol kinase; Provisional; Region: glpK; PRK00047 1323661003793 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1323661003794 N- and C-terminal domain interface [polypeptide binding]; other site 1323661003795 active site 1323661003796 MgATP binding site [chemical binding]; other site 1323661003797 catalytic site [active] 1323661003798 metal binding site [ion binding]; metal-binding site 1323661003799 glycerol binding site [chemical binding]; other site 1323661003800 homotetramer interface [polypeptide binding]; other site 1323661003801 homodimer interface [polypeptide binding]; other site 1323661003802 FBP binding site [chemical binding]; other site 1323661003803 protein IIAGlc interface [polypeptide binding]; other site 1323661003804 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1323661003805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661003806 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1323661003807 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1323661003808 PGAP1-like protein; Region: PGAP1; pfam07819 1323661003809 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 1323661003810 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1323661003811 bacterial Hfq-like; Region: Hfq; cd01716 1323661003812 hexamer interface [polypeptide binding]; other site 1323661003813 Sm1 motif; other site 1323661003814 RNA binding site [nucleotide binding]; other site 1323661003815 Sm2 motif; other site 1323661003816 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1323661003817 catalytic residues [active] 1323661003818 dimer interface [polypeptide binding]; other site 1323661003819 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1323661003820 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1323661003821 HflX GTPase family; Region: HflX; cd01878 1323661003822 G1 box; other site 1323661003823 GTP/Mg2+ binding site [chemical binding]; other site 1323661003824 Switch I region; other site 1323661003825 G2 box; other site 1323661003826 G3 box; other site 1323661003827 Switch II region; other site 1323661003828 G4 box; other site 1323661003829 G5 box; other site 1323661003830 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1323661003831 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1323661003832 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1323661003833 DNA binding residues [nucleotide binding] 1323661003834 putative dimer interface [polypeptide binding]; other site 1323661003835 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1323661003836 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1323661003837 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1323661003838 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 1323661003839 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1323661003840 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 1323661003841 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1323661003842 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1323661003843 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 1323661003844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661003845 non-specific DNA binding site [nucleotide binding]; other site 1323661003846 salt bridge; other site 1323661003847 sequence-specific DNA binding site [nucleotide binding]; other site 1323661003848 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 1323661003849 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 1323661003850 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 1323661003851 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1323661003852 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1323661003853 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1323661003854 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 1323661003855 putative metal binding site [ion binding]; other site 1323661003856 positive control sigma-like factor; Validated; Region: PRK06930 1323661003857 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1323661003858 DNA binding residues [nucleotide binding] 1323661003859 Homeodomain-like domain; Region: HTH_23; pfam13384 1323661003860 Phage terminase large subunit; Region: Terminase_3; cl12054 1323661003861 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1323661003862 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 1323661003863 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1323661003864 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1323661003865 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1323661003866 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1323661003867 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1323661003868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1323661003869 catalytic residue [active] 1323661003870 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1323661003871 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1323661003872 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1323661003873 putative active site [active] 1323661003874 catalytic site [active] 1323661003875 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1323661003876 putative active site [active] 1323661003877 catalytic site [active] 1323661003878 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1323661003879 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1323661003880 Walker A/P-loop; other site 1323661003881 ATP binding site [chemical binding]; other site 1323661003882 Q-loop/lid; other site 1323661003883 ABC transporter signature motif; other site 1323661003884 Walker B; other site 1323661003885 D-loop; other site 1323661003886 H-loop/switch region; other site 1323661003887 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1323661003888 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1323661003889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1323661003890 Predicted membrane protein [Function unknown]; Region: COG3463 1323661003891 Histidine kinase; Region: HisKA_3; pfam07730 1323661003892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661003893 ATP binding site [chemical binding]; other site 1323661003894 Mg2+ binding site [ion binding]; other site 1323661003895 G-X-G motif; other site 1323661003896 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1323661003897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661003898 active site 1323661003899 phosphorylation site [posttranslational modification] 1323661003900 intermolecular recognition site; other site 1323661003901 dimerization interface [polypeptide binding]; other site 1323661003902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1323661003903 DNA binding residues [nucleotide binding] 1323661003904 dimerization interface [polypeptide binding]; other site 1323661003905 Staphylococcal nuclease homologues; Region: SNc; smart00318 1323661003906 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1323661003907 Catalytic site; other site 1323661003908 AAA domain; Region: AAA_11; pfam13086 1323661003909 aspartate kinase; Reviewed; Region: PRK09034 1323661003910 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1323661003911 putative catalytic residues [active] 1323661003912 putative nucleotide binding site [chemical binding]; other site 1323661003913 putative aspartate binding site [chemical binding]; other site 1323661003914 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1323661003915 allosteric regulatory residue; other site 1323661003916 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1323661003917 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1323661003918 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1323661003919 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1323661003920 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1323661003921 homodimer interface [polypeptide binding]; other site 1323661003922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661003923 catalytic residue [active] 1323661003924 homoserine kinase; Provisional; Region: PRK01212 1323661003925 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1323661003926 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1323661003927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661003928 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1323661003929 active site 1323661003930 motif I; other site 1323661003931 motif II; other site 1323661003932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661003933 lysine transporter; Provisional; Region: PRK10836 1323661003934 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1323661003935 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1323661003936 tetramer interface [polypeptide binding]; other site 1323661003937 heme binding pocket [chemical binding]; other site 1323661003938 NADPH binding site [chemical binding]; other site 1323661003939 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1323661003940 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1323661003941 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1323661003942 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1323661003943 active site 1323661003944 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 1323661003945 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1323661003946 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1323661003947 LexA repressor; Validated; Region: PRK00215 1323661003948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1323661003949 putative DNA binding site [nucleotide binding]; other site 1323661003950 putative Zn2+ binding site [ion binding]; other site 1323661003951 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1323661003952 Catalytic site [active] 1323661003953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1323661003954 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1323661003955 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1323661003956 TPP-binding site [chemical binding]; other site 1323661003957 dimer interface [polypeptide binding]; other site 1323661003958 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1323661003959 PYR/PP interface [polypeptide binding]; other site 1323661003960 dimer interface [polypeptide binding]; other site 1323661003961 TPP binding site [chemical binding]; other site 1323661003962 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1323661003963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1323661003964 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1323661003965 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1323661003966 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1323661003967 active site 1323661003968 metal binding site [ion binding]; metal-binding site 1323661003969 DNA binding site [nucleotide binding] 1323661003970 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1323661003971 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1323661003972 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1323661003973 Walker A/P-loop; other site 1323661003974 ATP binding site [chemical binding]; other site 1323661003975 Q-loop/lid; other site 1323661003976 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1323661003977 ABC transporter signature motif; other site 1323661003978 Walker B; other site 1323661003979 D-loop; other site 1323661003980 H-loop/switch region; other site 1323661003981 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1323661003982 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1323661003983 aconitate hydratase; Validated; Region: PRK09277 1323661003984 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1323661003985 substrate binding site [chemical binding]; other site 1323661003986 ligand binding site [chemical binding]; other site 1323661003987 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1323661003988 substrate binding site [chemical binding]; other site 1323661003989 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1323661003990 active site 1323661003991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1323661003992 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1323661003993 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1323661003994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661003995 ATP binding site [chemical binding]; other site 1323661003996 Mg2+ binding site [ion binding]; other site 1323661003997 G-X-G motif; other site 1323661003998 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1323661003999 anchoring element; other site 1323661004000 dimer interface [polypeptide binding]; other site 1323661004001 ATP binding site [chemical binding]; other site 1323661004002 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1323661004003 active site 1323661004004 putative metal-binding site [ion binding]; other site 1323661004005 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1323661004006 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1323661004007 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1323661004008 CAP-like domain; other site 1323661004009 active site 1323661004010 primary dimer interface [polypeptide binding]; other site 1323661004011 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1323661004012 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1323661004013 CAT RNA binding domain; Region: CAT_RBD; cl03904 1323661004014 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1323661004015 PRD domain; Region: PRD; pfam00874 1323661004016 PRD domain; Region: PRD; pfam00874 1323661004017 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1323661004018 Predicted integral membrane protein [Function unknown]; Region: COG0392 1323661004019 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1323661004020 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1323661004021 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1323661004022 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1323661004023 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1323661004024 active site 1 [active] 1323661004025 dimer interface [polypeptide binding]; other site 1323661004026 hexamer interface [polypeptide binding]; other site 1323661004027 active site 2 [active] 1323661004028 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1323661004029 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1323661004030 active site 1323661004031 DNA binding site [nucleotide binding] 1323661004032 prephenate dehydrogenase; Validated; Region: PRK06545 1323661004033 prephenate dehydrogenase; Validated; Region: PRK08507 1323661004034 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1323661004035 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1323661004036 putative oligomer interface [polypeptide binding]; other site 1323661004037 putative active site [active] 1323661004038 metal binding site [ion binding]; metal-binding site 1323661004039 anthranilate synthase component I; Provisional; Region: PRK13567 1323661004040 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1323661004041 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1323661004042 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1323661004043 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1323661004044 glutamine binding [chemical binding]; other site 1323661004045 catalytic triad [active] 1323661004046 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1323661004047 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1323661004048 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1323661004049 active site 1323661004050 ribulose/triose binding site [chemical binding]; other site 1323661004051 phosphate binding site [ion binding]; other site 1323661004052 substrate (anthranilate) binding pocket [chemical binding]; other site 1323661004053 product (indole) binding pocket [chemical binding]; other site 1323661004054 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1323661004055 active site 1323661004056 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1323661004057 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1323661004058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661004059 catalytic residue [active] 1323661004060 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1323661004061 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1323661004062 substrate binding site [chemical binding]; other site 1323661004063 active site 1323661004064 catalytic residues [active] 1323661004065 heterodimer interface [polypeptide binding]; other site 1323661004066 FemAB family; Region: FemAB; pfam02388 1323661004067 FemAB family; Region: FemAB; pfam02388 1323661004068 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1323661004069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661004070 active site 1323661004071 motif I; other site 1323661004072 motif II; other site 1323661004073 SWIM zinc finger; Region: SWIM; pfam04434 1323661004074 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1323661004075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661004076 Walker A/P-loop; other site 1323661004077 ATP binding site [chemical binding]; other site 1323661004078 Q-loop/lid; other site 1323661004079 ABC transporter signature motif; other site 1323661004080 Walker B; other site 1323661004081 D-loop; other site 1323661004082 H-loop/switch region; other site 1323661004083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661004084 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1323661004085 Walker A/P-loop; other site 1323661004086 ATP binding site [chemical binding]; other site 1323661004087 Q-loop/lid; other site 1323661004088 ABC transporter signature motif; other site 1323661004089 Walker B; other site 1323661004090 D-loop; other site 1323661004091 H-loop/switch region; other site 1323661004092 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1323661004093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661004094 dimer interface [polypeptide binding]; other site 1323661004095 conserved gate region; other site 1323661004096 putative PBP binding loops; other site 1323661004097 ABC-ATPase subunit interface; other site 1323661004098 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1323661004099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661004100 dimer interface [polypeptide binding]; other site 1323661004101 conserved gate region; other site 1323661004102 putative PBP binding loops; other site 1323661004103 ABC-ATPase subunit interface; other site 1323661004104 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1323661004105 oligoendopeptidase F; Region: pepF; TIGR00181 1323661004106 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1323661004107 active site 1323661004108 Zn binding site [ion binding]; other site 1323661004109 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1323661004110 PhoU domain; Region: PhoU; pfam01895 1323661004111 PhoU domain; Region: PhoU; pfam01895 1323661004112 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1323661004113 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1323661004114 Walker A/P-loop; other site 1323661004115 ATP binding site [chemical binding]; other site 1323661004116 Q-loop/lid; other site 1323661004117 ABC transporter signature motif; other site 1323661004118 Walker B; other site 1323661004119 D-loop; other site 1323661004120 H-loop/switch region; other site 1323661004121 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1323661004122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661004123 dimer interface [polypeptide binding]; other site 1323661004124 conserved gate region; other site 1323661004125 putative PBP binding loops; other site 1323661004126 ABC-ATPase subunit interface; other site 1323661004127 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1323661004128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661004129 dimer interface [polypeptide binding]; other site 1323661004130 conserved gate region; other site 1323661004131 putative PBP binding loops; other site 1323661004132 ABC-ATPase subunit interface; other site 1323661004133 phosphate binding protein; Region: ptsS_2; TIGR02136 1323661004134 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1323661004135 S1 domain; Region: S1_2; pfam13509 1323661004136 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1323661004137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1323661004138 ABC transporter; Region: ABC_tran_2; pfam12848 1323661004139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1323661004140 aspartate kinase; Reviewed; Region: PRK06635 1323661004141 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1323661004142 putative nucleotide binding site [chemical binding]; other site 1323661004143 putative catalytic residues [active] 1323661004144 putative Mg ion binding site [ion binding]; other site 1323661004145 putative aspartate binding site [chemical binding]; other site 1323661004146 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1323661004147 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1323661004148 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1323661004149 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 1323661004150 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 1323661004151 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1323661004152 dimer interface [polypeptide binding]; other site 1323661004153 active site 1323661004154 catalytic residue [active] 1323661004155 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1323661004156 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1323661004157 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1323661004158 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1323661004159 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1323661004160 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1323661004161 trimer interface [polypeptide binding]; other site 1323661004162 active site 1323661004163 substrate binding site [chemical binding]; other site 1323661004164 CoA binding site [chemical binding]; other site 1323661004165 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1323661004166 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1323661004167 metal binding site [ion binding]; metal-binding site 1323661004168 dimer interface [polypeptide binding]; other site 1323661004169 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1323661004170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1323661004171 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1323661004172 catalytic residue [active] 1323661004173 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1323661004174 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1323661004175 active site 1323661004176 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1323661004177 substrate binding site [chemical binding]; other site 1323661004178 catalytic residues [active] 1323661004179 dimer interface [polypeptide binding]; other site 1323661004180 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1323661004181 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1323661004182 DNA-binding site [nucleotide binding]; DNA binding site 1323661004183 RNA-binding motif; other site 1323661004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1323661004185 acylphosphatase; Provisional; Region: PRK14431 1323661004186 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1323661004187 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1323661004188 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1323661004189 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1323661004190 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1323661004191 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1323661004192 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1323661004193 metal ion-dependent adhesion site (MIDAS); other site 1323661004194 MoxR-like ATPases [General function prediction only]; Region: COG0714 1323661004195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661004196 Walker A motif; other site 1323661004197 ATP binding site [chemical binding]; other site 1323661004198 Walker B motif; other site 1323661004199 arginine finger; other site 1323661004200 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1323661004201 active site 1323661004202 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1323661004203 active site 1323661004204 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1323661004205 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1323661004206 E3 interaction surface; other site 1323661004207 lipoyl attachment site [posttranslational modification]; other site 1323661004208 e3 binding domain; Region: E3_binding; pfam02817 1323661004209 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1323661004210 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1323661004211 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1323661004212 TPP-binding site [chemical binding]; other site 1323661004213 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1323661004214 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1323661004215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1323661004216 HAMP domain; Region: HAMP; pfam00672 1323661004217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1323661004218 dimer interface [polypeptide binding]; other site 1323661004219 phosphorylation site [posttranslational modification] 1323661004220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661004221 ATP binding site [chemical binding]; other site 1323661004222 Mg2+ binding site [ion binding]; other site 1323661004223 G-X-G motif; other site 1323661004224 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661004225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661004226 active site 1323661004227 phosphorylation site [posttranslational modification] 1323661004228 intermolecular recognition site; other site 1323661004229 dimerization interface [polypeptide binding]; other site 1323661004230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661004231 DNA binding site [nucleotide binding] 1323661004232 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1323661004233 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1323661004234 active site 1323661004235 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1323661004236 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1323661004237 active site 1323661004238 homodimer interface [polypeptide binding]; other site 1323661004239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1323661004240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661004241 Coenzyme A binding pocket [chemical binding]; other site 1323661004242 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1323661004243 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1323661004244 Catalytic dyad [active] 1323661004245 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1323661004246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 1323661004247 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1323661004248 HPr interaction site; other site 1323661004249 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1323661004250 active site 1323661004251 phosphorylation site [posttranslational modification] 1323661004252 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1323661004253 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1323661004254 EDD domain protein, DegV family; Region: DegV; TIGR00762 1323661004255 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1323661004256 folate binding site [chemical binding]; other site 1323661004257 NADP+ binding site [chemical binding]; other site 1323661004258 thymidylate synthase; Region: thym_sym; TIGR03284 1323661004259 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1323661004260 dimerization interface [polypeptide binding]; other site 1323661004261 active site 1323661004262 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1323661004263 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1323661004264 Virulence factor; Region: Virulence_fact; pfam13769 1323661004265 HEAT repeats; Region: HEAT_2; pfam13646 1323661004266 HEAT repeat; Region: HEAT; pfam02985 1323661004267 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1323661004268 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1323661004269 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 1323661004270 RNA/DNA hybrid binding site [nucleotide binding]; other site 1323661004271 active site 1323661004272 GA module; Region: GA; smart00844 1323661004273 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1323661004274 GA module; Region: GA; smart00844 1323661004275 GA module; Region: GA; smart00844 1323661004276 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661004277 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661004278 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661004279 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661004280 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1323661004281 GA module; Region: GA; smart00844 1323661004282 GA module; Region: GA; smart00844 1323661004283 GA module; Region: GA; smart00844 1323661004284 GA module; Region: GA; smart00844 1323661004285 GA module; Region: GA; smart00844 1323661004286 GA module; Region: GA; smart00844 1323661004287 GA module; Region: GA; smart00844 1323661004288 GA module; Region: GA; smart00844 1323661004289 GA module; Region: GA; smart00844 1323661004290 GA module; Region: GA; smart00844 1323661004291 GA module; Region: GA; smart00844 1323661004292 GA module; Region: GA; smart00844 1323661004293 GA module; Region: GA; smart00844 1323661004294 GA module; Region: GA; smart00844 1323661004295 GA module; Region: GA; smart00844 1323661004296 GA module; Region: GA; smart00844 1323661004297 GA module; Region: GA; smart00844 1323661004298 GA module; Region: GA; smart00844 1323661004299 GA module; Region: GA; smart00844 1323661004300 GA module; Region: GA; smart00844 1323661004301 GA module; Region: GA; smart00844 1323661004302 GA module; Region: GA; smart00844 1323661004303 Predicted membrane protein [Function unknown]; Region: COG1511 1323661004304 GA module; Region: GA; smart00844 1323661004305 GA module; Region: GA; smart00844 1323661004306 GA module; Region: GA; smart00844 1323661004307 GA module; Region: GA; smart00844 1323661004308 GA module; Region: GA; pfam01468 1323661004309 GA module; Region: GA; smart00844 1323661004310 GA module; Region: GA; smart00844 1323661004311 GA module; Region: GA; smart00844 1323661004312 GA module; Region: GA; smart00844 1323661004313 GA module; Region: GA; smart00844 1323661004314 GA module; Region: GA; smart00844 1323661004315 GA module; Region: GA; smart00844 1323661004316 GA module; Region: GA; smart00844 1323661004317 GA module; Region: GA; smart00844 1323661004318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661004319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661004320 putative substrate translocation pore; other site 1323661004321 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1323661004322 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1323661004323 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1323661004324 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1323661004325 tetramer interface [polypeptide binding]; other site 1323661004326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661004327 catalytic residue [active] 1323661004328 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1323661004329 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1323661004330 hexamer interface [polypeptide binding]; other site 1323661004331 ligand binding site [chemical binding]; other site 1323661004332 putative active site [active] 1323661004333 NAD(P) binding site [chemical binding]; other site 1323661004334 5'-3' exonuclease; Region: 53EXOc; smart00475 1323661004335 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1323661004336 active site 1323661004337 metal binding site 1 [ion binding]; metal-binding site 1323661004338 putative 5' ssDNA interaction site; other site 1323661004339 metal binding site 3; metal-binding site 1323661004340 metal binding site 2 [ion binding]; metal-binding site 1323661004341 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1323661004342 putative DNA binding site [nucleotide binding]; other site 1323661004343 putative metal binding site [ion binding]; other site 1323661004344 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1323661004345 G1 box; other site 1323661004346 GTP/Mg2+ binding site [chemical binding]; other site 1323661004347 G2 box; other site 1323661004348 Switch I region; other site 1323661004349 G3 box; other site 1323661004350 Switch II region; other site 1323661004351 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1323661004352 G4 box; other site 1323661004353 Dynamin family; Region: Dynamin_N; pfam00350 1323661004354 G1 box; other site 1323661004355 GTP/Mg2+ binding site [chemical binding]; other site 1323661004356 G2 box; other site 1323661004357 Switch I region; other site 1323661004358 G3 box; other site 1323661004359 Switch II region; other site 1323661004360 G4 box; other site 1323661004361 G5 box; other site 1323661004362 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1323661004363 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1323661004364 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1323661004365 Cobalt transport protein component CbiN; Region: CbiN; cl00842 1323661004366 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1323661004367 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1323661004368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1323661004369 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 1323661004370 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1323661004371 hypothetical protein; Provisional; Region: PRK13660 1323661004372 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1323661004373 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1323661004374 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1323661004375 Transglycosylase; Region: Transgly; pfam00912 1323661004376 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1323661004377 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1323661004378 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1323661004379 minor groove reading motif; other site 1323661004380 helix-hairpin-helix signature motif; other site 1323661004381 substrate binding pocket [chemical binding]; other site 1323661004382 active site 1323661004383 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1323661004384 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1323661004385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1323661004386 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1323661004387 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1323661004388 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1323661004389 putative dimer interface [polypeptide binding]; other site 1323661004390 putative anticodon binding site; other site 1323661004391 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1323661004392 homodimer interface [polypeptide binding]; other site 1323661004393 motif 1; other site 1323661004394 motif 2; other site 1323661004395 active site 1323661004396 motif 3; other site 1323661004397 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1323661004398 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1323661004399 active site 1323661004400 catalytic site [active] 1323661004401 substrate binding site [chemical binding]; other site 1323661004402 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1323661004403 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1323661004404 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1323661004405 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1323661004406 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1323661004407 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1323661004408 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1323661004409 active site 1323661004410 NTP binding site [chemical binding]; other site 1323661004411 metal binding triad [ion binding]; metal-binding site 1323661004412 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1323661004413 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1323661004414 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1323661004415 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1323661004416 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1323661004417 homodimer interface [polypeptide binding]; other site 1323661004418 metal binding site [ion binding]; metal-binding site 1323661004419 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1323661004420 Predicted membrane protein [Function unknown]; Region: COG4347 1323661004421 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1323661004422 UPF0302 domain; Region: UPF0302; pfam08864 1323661004423 IDEAL domain; Region: IDEAL; pfam08858 1323661004424 TPR repeat; Region: TPR_11; pfam13414 1323661004425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1323661004426 binding surface 1323661004427 TPR motif; other site 1323661004428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1323661004429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1323661004430 TPR motif; other site 1323661004431 binding surface 1323661004432 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1323661004433 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1323661004434 hinge; other site 1323661004435 active site 1323661004436 Dehydroquinate synthase-like which includes dehydroquinate synthase, 2-deoxy-scyllo-inosose synthase, and 2-epi-5-epi-valiolone synthase; Region: DHQ-like; cd08169 1323661004437 active site 1323661004438 dimer interface [polypeptide binding]; other site 1323661004439 metal binding site [ion binding]; metal-binding site 1323661004440 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1323661004441 Tetramer interface [polypeptide binding]; other site 1323661004442 active site 1323661004443 FMN-binding site [chemical binding]; other site 1323661004444 Nucleoside diphosphate kinase; Region: NDK; pfam00334 1323661004445 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1323661004446 active site 1323661004447 multimer interface [polypeptide binding]; other site 1323661004448 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1323661004449 substrate binding pocket [chemical binding]; other site 1323661004450 chain length determination region; other site 1323661004451 substrate-Mg2+ binding site; other site 1323661004452 catalytic residues [active] 1323661004453 aspartate-rich region 1; other site 1323661004454 active site lid residues [active] 1323661004455 aspartate-rich region 2; other site 1323661004456 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1323661004457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661004458 S-adenosylmethionine binding site [chemical binding]; other site 1323661004459 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1323661004460 histone-like DNA-binding protein HU; Region: HU; cd13831 1323661004461 dimer interface [polypeptide binding]; other site 1323661004462 DNA binding site [nucleotide binding] 1323661004463 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1323661004464 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1323661004465 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1323661004466 GTP-binding protein Der; Reviewed; Region: PRK00093 1323661004467 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1323661004468 G1 box; other site 1323661004469 GTP/Mg2+ binding site [chemical binding]; other site 1323661004470 Switch I region; other site 1323661004471 G2 box; other site 1323661004472 Switch II region; other site 1323661004473 G3 box; other site 1323661004474 G4 box; other site 1323661004475 G5 box; other site 1323661004476 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1323661004477 G1 box; other site 1323661004478 GTP/Mg2+ binding site [chemical binding]; other site 1323661004479 Switch I region; other site 1323661004480 G2 box; other site 1323661004481 G3 box; other site 1323661004482 Switch II region; other site 1323661004483 G4 box; other site 1323661004484 G5 box; other site 1323661004485 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 1323661004486 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1323661004487 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1323661004488 RNA binding site [nucleotide binding]; other site 1323661004489 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1323661004490 RNA binding site [nucleotide binding]; other site 1323661004491 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1323661004492 RNA binding site [nucleotide binding]; other site 1323661004493 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1323661004494 RNA binding site [nucleotide binding]; other site 1323661004495 cytidylate kinase; Provisional; Region: cmk; PRK00023 1323661004496 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1323661004497 CMP-binding site; other site 1323661004498 The sites determining sugar specificity; other site 1323661004499 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 1323661004500 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1323661004501 active site 1323661004502 homotetramer interface [polypeptide binding]; other site 1323661004503 homodimer interface [polypeptide binding]; other site 1323661004504 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1323661004505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1323661004506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661004507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1323661004508 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1323661004509 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661004510 ATP binding site [chemical binding]; other site 1323661004511 putative Mg++ binding site [ion binding]; other site 1323661004512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661004513 nucleotide binding region [chemical binding]; other site 1323661004514 ATP-binding site [chemical binding]; other site 1323661004515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1323661004516 Helix-turn-helix domain; Region: HTH_40; pfam14493 1323661004517 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1323661004518 Predicted membrane protein [Function unknown]; Region: COG3601 1323661004519 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1323661004520 CHAP domain; Region: CHAP; pfam05257 1323661004521 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1323661004522 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1323661004523 active site 1323661004524 metal binding site [ion binding]; metal-binding site 1323661004525 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1323661004526 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1323661004527 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1323661004528 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1323661004529 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 1323661004530 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1323661004531 hypothetical protein; Provisional; Region: PRK05926 1323661004532 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1323661004533 Phage tail protein; Region: Sipho_tail; pfam05709 1323661004534 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1323661004535 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 1323661004536 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1323661004537 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1323661004538 dimer interface [polypeptide binding]; other site 1323661004539 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1323661004540 Peptidase family M23; Region: Peptidase_M23; pfam01551 1323661004541 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1323661004542 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1323661004543 catalytic residue [active] 1323661004544 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1323661004545 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1323661004546 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1323661004547 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1323661004548 oligomerization interface [polypeptide binding]; other site 1323661004549 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1323661004550 Phage capsid family; Region: Phage_capsid; pfam05065 1323661004551 Clp protease; Region: CLP_protease; pfam00574 1323661004552 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1323661004553 oligomer interface [polypeptide binding]; other site 1323661004554 active site residues [active] 1323661004555 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1323661004556 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1323661004557 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1323661004558 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1323661004559 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1323661004560 active site 1323661004561 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1323661004562 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1323661004563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661004564 ATP binding site [chemical binding]; other site 1323661004565 putative Mg++ binding site [ion binding]; other site 1323661004566 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1323661004567 VRR-NUC domain; Region: VRR_NUC; pfam08774 1323661004568 Virulence-associated protein E; Region: VirE; pfam05272 1323661004569 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1323661004570 Transcriptional activator RinB; Region: RinB; pfam06116 1323661004571 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1323661004572 dUTPase; Region: dUTPase_2; pfam08761 1323661004573 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1323661004574 active site 1323661004575 homodimer interface [polypeptide binding]; other site 1323661004576 metal binding site [ion binding]; metal-binding site 1323661004577 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1323661004578 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1323661004579 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1323661004580 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1323661004581 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 1323661004582 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 1323661004583 active site 1323661004584 DNA binding site [nucleotide binding] 1323661004585 catalytic site [active] 1323661004586 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1323661004587 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1323661004588 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1323661004589 Homeodomain-like domain; Region: HTH_23; pfam13384 1323661004590 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 1323661004591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661004592 non-specific DNA binding site [nucleotide binding]; other site 1323661004593 salt bridge; other site 1323661004594 sequence-specific DNA binding site [nucleotide binding]; other site 1323661004595 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1323661004596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661004597 non-specific DNA binding site [nucleotide binding]; other site 1323661004598 salt bridge; other site 1323661004599 sequence-specific DNA binding site [nucleotide binding]; other site 1323661004600 Predicted transcriptional regulator [Transcription]; Region: COG2932 1323661004601 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1323661004602 Catalytic site [active] 1323661004603 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1323661004604 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1323661004605 Int/Topo IB signature motif; other site 1323661004606 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1323661004607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1323661004608 dimerization interface [polypeptide binding]; other site 1323661004609 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1323661004610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1323661004611 dimer interface [polypeptide binding]; other site 1323661004612 phosphorylation site [posttranslational modification] 1323661004613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661004614 ATP binding site [chemical binding]; other site 1323661004615 Mg2+ binding site [ion binding]; other site 1323661004616 G-X-G motif; other site 1323661004617 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661004618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661004619 active site 1323661004620 phosphorylation site [posttranslational modification] 1323661004621 intermolecular recognition site; other site 1323661004622 dimerization interface [polypeptide binding]; other site 1323661004623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661004624 DNA binding site [nucleotide binding] 1323661004625 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1323661004626 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1323661004627 RNA binding surface [nucleotide binding]; other site 1323661004628 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1323661004629 active site 1323661004630 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1323661004631 ScpA/B protein; Region: ScpA_ScpB; cl00598 1323661004632 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1323661004633 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1323661004634 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1323661004635 active site 1323661004636 Int/Topo IB signature motif; other site 1323661004637 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1323661004638 metal binding site 2 [ion binding]; metal-binding site 1323661004639 putative DNA binding helix; other site 1323661004640 metal binding site 1 [ion binding]; metal-binding site 1323661004641 dimer interface [polypeptide binding]; other site 1323661004642 structural Zn2+ binding site [ion binding]; other site 1323661004643 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1323661004644 dimer interface [polypeptide binding]; other site 1323661004645 ADP-ribose binding site [chemical binding]; other site 1323661004646 active site 1323661004647 nudix motif; other site 1323661004648 metal binding site [ion binding]; metal-binding site 1323661004649 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1323661004650 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1323661004651 active site 1323661004652 catalytic tetrad [active] 1323661004653 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1323661004654 classical (c) SDRs; Region: SDR_c; cd05233 1323661004655 NAD(P) binding site [chemical binding]; other site 1323661004656 active site 1323661004657 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1323661004658 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1323661004659 ribonuclease Z; Region: RNase_Z; TIGR02651 1323661004660 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1323661004661 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1323661004662 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1323661004663 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1323661004664 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1323661004665 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1323661004666 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1323661004667 Ca binding site [ion binding]; other site 1323661004668 active site 1323661004669 catalytic site [active] 1323661004670 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1323661004671 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1323661004672 DNA binding site [nucleotide binding] 1323661004673 domain linker motif; other site 1323661004674 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1323661004675 putative ligand binding site [chemical binding]; other site 1323661004676 putative dimerization interface [polypeptide binding]; other site 1323661004677 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1323661004678 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1323661004679 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1323661004680 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1323661004681 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1323661004682 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1323661004683 peptidase T-like protein; Region: PepT-like; TIGR01883 1323661004684 metal binding site [ion binding]; metal-binding site 1323661004685 putative dimer interface [polypeptide binding]; other site 1323661004686 Predicted membrane protein [Function unknown]; Region: COG4129 1323661004687 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1323661004688 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1323661004689 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1323661004690 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1323661004691 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1323661004692 E3 interaction surface; other site 1323661004693 lipoyl attachment site [posttranslational modification]; other site 1323661004694 e3 binding domain; Region: E3_binding; pfam02817 1323661004695 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1323661004696 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1323661004697 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1323661004698 alpha subunit interface [polypeptide binding]; other site 1323661004699 TPP binding site [chemical binding]; other site 1323661004700 heterodimer interface [polypeptide binding]; other site 1323661004701 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1323661004702 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1323661004703 tetramer interface [polypeptide binding]; other site 1323661004704 TPP-binding site [chemical binding]; other site 1323661004705 heterodimer interface [polypeptide binding]; other site 1323661004706 phosphorylation loop region [posttranslational modification] 1323661004707 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1323661004708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661004709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661004710 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 1323661004711 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1323661004712 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1323661004713 Walker A/P-loop; other site 1323661004714 ATP binding site [chemical binding]; other site 1323661004715 Q-loop/lid; other site 1323661004716 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1323661004717 ABC transporter signature motif; other site 1323661004718 Walker B; other site 1323661004719 D-loop; other site 1323661004720 H-loop/switch region; other site 1323661004721 arginine repressor; Provisional; Region: PRK04280 1323661004722 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1323661004723 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1323661004724 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1323661004725 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1323661004726 substrate binding pocket [chemical binding]; other site 1323661004727 chain length determination region; other site 1323661004728 substrate-Mg2+ binding site; other site 1323661004729 catalytic residues [active] 1323661004730 aspartate-rich region 1; other site 1323661004731 active site lid residues [active] 1323661004732 aspartate-rich region 2; other site 1323661004733 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1323661004734 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1323661004735 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1323661004736 generic binding surface II; other site 1323661004737 generic binding surface I; other site 1323661004738 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 1323661004739 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1323661004740 putative RNA binding site [nucleotide binding]; other site 1323661004741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1323661004742 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1323661004743 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1323661004744 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1323661004745 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1323661004746 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1323661004747 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1323661004748 carboxyltransferase (CT) interaction site; other site 1323661004749 biotinylation site [posttranslational modification]; other site 1323661004750 elongation factor P; Validated; Region: PRK00529 1323661004751 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1323661004752 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1323661004753 RNA binding site [nucleotide binding]; other site 1323661004754 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1323661004755 RNA binding site [nucleotide binding]; other site 1323661004756 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1323661004757 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1323661004758 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1323661004759 active site 1323661004760 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1323661004761 Nucleopolyhedrovirus protein of unknown function (DUF912); Region: DUF912; pfam06024 1323661004762 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1323661004763 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1323661004764 active site residue [active] 1323661004765 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1323661004766 tetramer interface [polypeptide binding]; other site 1323661004767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661004768 catalytic residue [active] 1323661004769 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1323661004770 tetramer interface [polypeptide binding]; other site 1323661004771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661004772 catalytic residue [active] 1323661004773 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1323661004774 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1323661004775 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1323661004776 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1323661004777 ADP binding site [chemical binding]; other site 1323661004778 magnesium binding site [ion binding]; other site 1323661004779 putative shikimate binding site; other site 1323661004780 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1323661004781 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1323661004782 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1323661004783 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1323661004784 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1323661004785 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1323661004786 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1323661004787 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1323661004788 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1323661004789 Walker A motif; other site 1323661004790 ATP binding site [chemical binding]; other site 1323661004791 Walker B motif; other site 1323661004792 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1323661004793 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1323661004794 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1323661004795 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1323661004796 nucleotide binding site [chemical binding]; other site 1323661004797 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1323661004798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661004799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1323661004800 binding surface 1323661004801 TPR motif; other site 1323661004802 TPR repeat; Region: TPR_11; pfam13414 1323661004803 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1323661004804 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1323661004805 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1323661004806 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1323661004807 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 1323661004808 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1323661004809 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1323661004810 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1323661004811 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1323661004812 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1323661004813 metal binding site 2 [ion binding]; metal-binding site 1323661004814 putative DNA binding helix; other site 1323661004815 metal binding site 1 [ion binding]; metal-binding site 1323661004816 dimer interface [polypeptide binding]; other site 1323661004817 structural Zn2+ binding site [ion binding]; other site 1323661004818 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1323661004819 ABC-ATPase subunit interface; other site 1323661004820 dimer interface [polypeptide binding]; other site 1323661004821 putative PBP binding regions; other site 1323661004822 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1323661004823 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1323661004824 endonuclease IV; Provisional; Region: PRK01060 1323661004825 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1323661004826 AP (apurinic/apyrimidinic) site pocket; other site 1323661004827 DNA interaction; other site 1323661004828 Metal-binding active site; metal-binding site 1323661004829 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1323661004830 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1323661004831 ATP binding site [chemical binding]; other site 1323661004832 putative Mg++ binding site [ion binding]; other site 1323661004833 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661004834 nucleotide binding region [chemical binding]; other site 1323661004835 ATP-binding site [chemical binding]; other site 1323661004836 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1323661004837 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1323661004838 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1323661004839 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1323661004840 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1323661004841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1323661004842 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1323661004843 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1323661004844 DNA binding residues [nucleotide binding] 1323661004845 DNA primase, catalytic core; Region: dnaG; TIGR01391 1323661004846 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1323661004847 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1323661004848 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1323661004849 active site 1323661004850 metal binding site [ion binding]; metal-binding site 1323661004851 interdomain interaction site; other site 1323661004852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1323661004853 FOG: CBS domain [General function prediction only]; Region: COG0517 1323661004854 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1323661004855 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1323661004856 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1323661004857 dimer interface [polypeptide binding]; other site 1323661004858 motif 1; other site 1323661004859 active site 1323661004860 motif 2; other site 1323661004861 motif 3; other site 1323661004862 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1323661004863 anticodon binding site; other site 1323661004864 DNA repair protein RecO; Region: reco; TIGR00613 1323661004865 Recombination protein O N terminal; Region: RecO_N; pfam11967 1323661004866 Recombination protein O C terminal; Region: RecO_C; pfam02565 1323661004867 GTPase Era; Reviewed; Region: era; PRK00089 1323661004868 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1323661004869 G1 box; other site 1323661004870 GTP/Mg2+ binding site [chemical binding]; other site 1323661004871 Switch I region; other site 1323661004872 G2 box; other site 1323661004873 Switch II region; other site 1323661004874 G3 box; other site 1323661004875 G4 box; other site 1323661004876 G5 box; other site 1323661004877 KH domain; Region: KH_2; pfam07650 1323661004878 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1323661004879 active site 1323661004880 catalytic motif [active] 1323661004881 Zn binding site [ion binding]; other site 1323661004882 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 1323661004883 trimer interface [polypeptide binding]; other site 1323661004884 putative active site [active] 1323661004885 Zn binding site [ion binding]; other site 1323661004886 metal-binding heat shock protein; Provisional; Region: PRK00016 1323661004887 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1323661004888 PhoH-like protein; Region: PhoH; pfam02562 1323661004889 DNA translocase FtsK; Provisional; Region: PRK10263 1323661004890 hypothetical protein; Provisional; Region: PRK13665 1323661004891 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1323661004892 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1323661004893 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1323661004894 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1323661004895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661004896 FeS/SAM binding site; other site 1323661004897 TRAM domain; Region: TRAM; cl01282 1323661004898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1323661004899 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1323661004900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661004901 S-adenosylmethionine binding site [chemical binding]; other site 1323661004902 chaperone protein DnaJ; Provisional; Region: PRK14280 1323661004903 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1323661004904 HSP70 interaction site [polypeptide binding]; other site 1323661004905 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1323661004906 substrate binding site [polypeptide binding]; other site 1323661004907 dimer interface [polypeptide binding]; other site 1323661004908 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1323661004909 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1323661004910 nucleotide binding site [chemical binding]; other site 1323661004911 NEF interaction site [polypeptide binding]; other site 1323661004912 SBD interface [polypeptide binding]; other site 1323661004913 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1323661004914 dimer interface [polypeptide binding]; other site 1323661004915 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1323661004916 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1323661004917 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1323661004918 HrcA protein C terminal domain; Region: HrcA; pfam01628 1323661004919 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1323661004920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661004921 FeS/SAM binding site; other site 1323661004922 HemN C-terminal domain; Region: HemN_C; pfam06969 1323661004923 GTP-binding protein LepA; Provisional; Region: PRK05433 1323661004924 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1323661004925 G1 box; other site 1323661004926 putative GEF interaction site [polypeptide binding]; other site 1323661004927 GTP/Mg2+ binding site [chemical binding]; other site 1323661004928 Switch I region; other site 1323661004929 G2 box; other site 1323661004930 G3 box; other site 1323661004931 Switch II region; other site 1323661004932 G4 box; other site 1323661004933 G5 box; other site 1323661004934 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1323661004935 Elongation Factor G, domain II; Region: EFG_II; pfam14492 1323661004936 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1323661004937 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1323661004938 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1323661004939 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1323661004940 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1323661004941 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1323661004942 Competence protein; Region: Competence; pfam03772 1323661004943 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1323661004944 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1323661004945 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1323661004946 catalytic motif [active] 1323661004947 Zn binding site [ion binding]; other site 1323661004948 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1323661004949 SLBB domain; Region: SLBB; pfam10531 1323661004950 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1323661004951 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1323661004952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661004953 S-adenosylmethionine binding site [chemical binding]; other site 1323661004954 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1323661004955 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1323661004956 Zn2+ binding site [ion binding]; other site 1323661004957 Mg2+ binding site [ion binding]; other site 1323661004958 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1323661004959 active site 1323661004960 (T/H)XGH motif; other site 1323661004961 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1323661004962 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1323661004963 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1323661004964 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1323661004965 shikimate binding site; other site 1323661004966 NAD(P) binding site [chemical binding]; other site 1323661004967 GTPase YqeH; Provisional; Region: PRK13796 1323661004968 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1323661004969 GTP/Mg2+ binding site [chemical binding]; other site 1323661004970 G4 box; other site 1323661004971 G5 box; other site 1323661004972 G1 box; other site 1323661004973 Switch I region; other site 1323661004974 G2 box; other site 1323661004975 G3 box; other site 1323661004976 Switch II region; other site 1323661004977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661004978 active site 1323661004979 motif I; other site 1323661004980 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1323661004981 motif II; other site 1323661004982 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1323661004983 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1323661004984 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1323661004985 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661004986 Fic family protein [Function unknown]; Region: COG3177 1323661004987 Fic/DOC family; Region: Fic; pfam02661 1323661004988 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1323661004989 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1323661004990 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1323661004991 putative active site [active] 1323661004992 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1323661004993 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1323661004994 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1323661004995 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1323661004996 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1323661004997 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1323661004998 carboxyltransferase (CT) interaction site; other site 1323661004999 biotinylation site [posttranslational modification]; other site 1323661005000 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1323661005001 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1323661005002 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1323661005003 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1323661005004 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1323661005005 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1323661005006 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1323661005007 Sugar specificity; other site 1323661005008 Pyrimidine base specificity; other site 1323661005009 ATP-binding site [chemical binding]; other site 1323661005010 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1323661005011 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1323661005012 Peptidase family U32; Region: Peptidase_U32; pfam01136 1323661005013 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1323661005014 Peptidase family U32; Region: Peptidase_U32; pfam01136 1323661005015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661005016 S-adenosylmethionine binding site [chemical binding]; other site 1323661005017 hypothetical protein; Provisional; Region: PRK13678 1323661005018 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1323661005019 hypothetical protein; Provisional; Region: PRK05473 1323661005020 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1323661005021 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1323661005022 motif 1; other site 1323661005023 active site 1323661005024 motif 2; other site 1323661005025 motif 3; other site 1323661005026 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1323661005027 DHHA1 domain; Region: DHHA1; pfam02272 1323661005028 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1323661005029 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 1323661005030 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 1323661005031 AAA domain; Region: AAA_30; pfam13604 1323661005032 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1323661005033 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1323661005034 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1323661005035 binding surface 1323661005036 TPR motif; other site 1323661005037 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1323661005038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1323661005039 binding surface 1323661005040 TPR motif; other site 1323661005041 TPR repeat; Region: TPR_11; pfam13414 1323661005042 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1323661005043 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1323661005044 Ligand Binding Site [chemical binding]; other site 1323661005045 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1323661005046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1323661005047 catalytic residue [active] 1323661005048 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1323661005049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1323661005050 Predicted transcriptional regulator [Transcription]; Region: COG1959 1323661005051 Rrf2 family protein; Region: rrf2_super; TIGR00738 1323661005052 recombination factor protein RarA; Reviewed; Region: PRK13342 1323661005053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661005054 Walker A motif; other site 1323661005055 ATP binding site [chemical binding]; other site 1323661005056 Walker B motif; other site 1323661005057 arginine finger; other site 1323661005058 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1323661005059 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1323661005060 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1323661005061 putative ATP binding site [chemical binding]; other site 1323661005062 putative substrate interface [chemical binding]; other site 1323661005063 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1323661005064 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1323661005065 dimer interface [polypeptide binding]; other site 1323661005066 anticodon binding site; other site 1323661005067 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1323661005068 homodimer interface [polypeptide binding]; other site 1323661005069 motif 1; other site 1323661005070 active site 1323661005071 motif 2; other site 1323661005072 motif 3; other site 1323661005073 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1323661005074 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1323661005075 dimer interface [polypeptide binding]; other site 1323661005076 motif 1; other site 1323661005077 active site 1323661005078 motif 2; other site 1323661005079 motif 3; other site 1323661005080 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1323661005081 anticodon binding site; other site 1323661005082 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1323661005083 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1323661005084 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1323661005085 active site 1323661005086 metal binding site [ion binding]; metal-binding site 1323661005087 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 1323661005088 putative active site [active] 1323661005089 putative tRNAtyr binding site [nucleotide binding]; other site 1323661005090 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1323661005091 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1323661005092 Zn2+ binding site [ion binding]; other site 1323661005093 Mg2+ binding site [ion binding]; other site 1323661005094 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1323661005095 synthetase active site [active] 1323661005096 NTP binding site [chemical binding]; other site 1323661005097 metal binding site [ion binding]; metal-binding site 1323661005098 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1323661005099 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1323661005100 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661005101 active site 1323661005102 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1323661005103 DHH family; Region: DHH; pfam01368 1323661005104 DHHA1 domain; Region: DHHA1; pfam02272 1323661005105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1323661005106 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1323661005107 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1323661005108 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1323661005109 Protein export membrane protein; Region: SecD_SecF; pfam02355 1323661005110 Preprotein translocase subunit; Region: YajC; pfam02699 1323661005111 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1323661005112 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1323661005113 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1323661005114 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1323661005115 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1323661005116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661005117 Walker A motif; other site 1323661005118 ATP binding site [chemical binding]; other site 1323661005119 Walker B motif; other site 1323661005120 arginine finger; other site 1323661005121 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1323661005122 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1323661005123 RuvA N terminal domain; Region: RuvA_N; pfam01330 1323661005124 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1323661005125 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 1323661005126 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1323661005127 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1323661005128 GTP1/OBG; Region: GTP1_OBG; pfam01018 1323661005129 Obg GTPase; Region: Obg; cd01898 1323661005130 G1 box; other site 1323661005131 GTP/Mg2+ binding site [chemical binding]; other site 1323661005132 Switch I region; other site 1323661005133 G2 box; other site 1323661005134 G3 box; other site 1323661005135 Switch II region; other site 1323661005136 G4 box; other site 1323661005137 G5 box; other site 1323661005138 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1323661005139 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1323661005140 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1323661005141 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1323661005142 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1323661005143 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1323661005144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661005145 S-adenosylmethionine binding site [chemical binding]; other site 1323661005146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661005147 S-adenosylmethionine binding site [chemical binding]; other site 1323661005148 aminoglycoside resistance protein; Provisional; Region: PRK13746 1323661005149 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1323661005150 active site 1323661005151 NTP binding site [chemical binding]; other site 1323661005152 metal binding triad [ion binding]; metal-binding site 1323661005153 antibiotic binding site [chemical binding]; other site 1323661005154 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1323661005155 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1323661005156 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1323661005157 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 1323661005158 Int/Topo IB signature motif; other site 1323661005159 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 1323661005160 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1323661005161 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 1323661005162 Int/Topo IB signature motif; other site 1323661005163 hypothetical protein; Reviewed; Region: PRK00024 1323661005164 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1323661005165 MPN+ (JAMM) motif; other site 1323661005166 Zinc-binding site [ion binding]; other site 1323661005167 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1323661005168 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1323661005169 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1323661005170 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1323661005171 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1323661005172 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1323661005173 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1323661005174 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1323661005175 active site 1323661005176 HIGH motif; other site 1323661005177 KMSKS motif; other site 1323661005178 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1323661005179 tRNA binding surface [nucleotide binding]; other site 1323661005180 anticodon binding site; other site 1323661005181 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1323661005182 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1323661005183 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1323661005184 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1323661005185 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1323661005186 inhibitor-cofactor binding pocket; inhibition site 1323661005187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661005188 catalytic residue [active] 1323661005189 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1323661005190 dimer interface [polypeptide binding]; other site 1323661005191 active site 1323661005192 Schiff base residues; other site 1323661005193 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1323661005194 active site 1323661005195 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1323661005196 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1323661005197 domain interfaces; other site 1323661005198 active site 1323661005199 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 1323661005200 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1323661005201 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1323661005202 tRNA; other site 1323661005203 putative tRNA binding site [nucleotide binding]; other site 1323661005204 putative NADP binding site [chemical binding]; other site 1323661005205 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 1323661005206 Predicted GTPase [General function prediction only]; Region: COG0218 1323661005207 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1323661005208 G1 box; other site 1323661005209 GTP/Mg2+ binding site [chemical binding]; other site 1323661005210 Switch I region; other site 1323661005211 G2 box; other site 1323661005212 G3 box; other site 1323661005213 Switch II region; other site 1323661005214 G4 box; other site 1323661005215 G5 box; other site 1323661005216 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1323661005217 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1323661005218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661005219 Walker A motif; other site 1323661005220 ATP binding site [chemical binding]; other site 1323661005221 Walker B motif; other site 1323661005222 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1323661005223 trigger factor; Provisional; Region: tig; PRK01490 1323661005224 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 1323661005225 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1323661005226 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1323661005227 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1323661005228 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1323661005229 23S rRNA binding site [nucleotide binding]; other site 1323661005230 L21 binding site [polypeptide binding]; other site 1323661005231 L13 binding site [polypeptide binding]; other site 1323661005232 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1323661005233 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1323661005234 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1323661005235 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1323661005236 lysine transporter; Provisional; Region: PRK10836 1323661005237 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1323661005238 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1323661005239 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1323661005240 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1323661005241 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1323661005242 active site 1323661005243 dimer interface [polypeptide binding]; other site 1323661005244 motif 1; other site 1323661005245 motif 2; other site 1323661005246 motif 3; other site 1323661005247 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1323661005248 anticodon binding site; other site 1323661005249 primosomal protein DnaI; Reviewed; Region: PRK08939 1323661005250 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1323661005251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661005252 Walker A motif; other site 1323661005253 ATP binding site [chemical binding]; other site 1323661005254 Walker B motif; other site 1323661005255 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1323661005256 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1323661005257 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1323661005258 ATP cone domain; Region: ATP-cone; pfam03477 1323661005259 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1323661005260 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1323661005261 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1323661005262 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1323661005263 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1323661005264 CoA-binding site [chemical binding]; other site 1323661005265 ATP-binding [chemical binding]; other site 1323661005266 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1323661005267 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1323661005268 DNA binding site [nucleotide binding] 1323661005269 catalytic residue [active] 1323661005270 H2TH interface [polypeptide binding]; other site 1323661005271 putative catalytic residues [active] 1323661005272 turnover-facilitating residue; other site 1323661005273 intercalation triad [nucleotide binding]; other site 1323661005274 8OG recognition residue [nucleotide binding]; other site 1323661005275 putative reading head residues; other site 1323661005276 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1323661005277 DNA polymerase I; Provisional; Region: PRK05755 1323661005278 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1323661005279 active site 1323661005280 metal binding site 1 [ion binding]; metal-binding site 1323661005281 putative 5' ssDNA interaction site; other site 1323661005282 metal binding site 3; metal-binding site 1323661005283 metal binding site 2 [ion binding]; metal-binding site 1323661005284 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1323661005285 putative DNA binding site [nucleotide binding]; other site 1323661005286 putative metal binding site [ion binding]; other site 1323661005287 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1323661005288 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1323661005289 active site 1323661005290 DNA binding site [nucleotide binding] 1323661005291 catalytic site [active] 1323661005292 HAMP domain; Region: HAMP; pfam00672 1323661005293 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1323661005294 PAS domain; Region: PAS_8; pfam13188 1323661005295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1323661005296 dimer interface [polypeptide binding]; other site 1323661005297 phosphorylation site [posttranslational modification] 1323661005298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661005299 ATP binding site [chemical binding]; other site 1323661005300 Mg2+ binding site [ion binding]; other site 1323661005301 G-X-G motif; other site 1323661005302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661005303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661005304 active site 1323661005305 phosphorylation site [posttranslational modification] 1323661005306 intermolecular recognition site; other site 1323661005307 dimerization interface [polypeptide binding]; other site 1323661005308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661005309 DNA binding site [nucleotide binding] 1323661005310 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1323661005311 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1323661005312 dimer interface [polypeptide binding]; other site 1323661005313 Citrate synthase; Region: Citrate_synt; pfam00285 1323661005314 active site 1323661005315 citrylCoA binding site [chemical binding]; other site 1323661005316 oxalacetate/citrate binding site [chemical binding]; other site 1323661005317 coenzyme A binding site [chemical binding]; other site 1323661005318 catalytic triad [active] 1323661005319 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1323661005320 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1323661005321 pyruvate kinase; Provisional; Region: PRK06354 1323661005322 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1323661005323 domain interfaces; other site 1323661005324 active site 1323661005325 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1323661005326 6-phosphofructokinase; Provisional; Region: PRK03202 1323661005327 active site 1323661005328 ADP/pyrophosphate binding site [chemical binding]; other site 1323661005329 dimerization interface [polypeptide binding]; other site 1323661005330 allosteric effector site; other site 1323661005331 fructose-1,6-bisphosphate binding site; other site 1323661005332 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1323661005333 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1323661005334 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1323661005335 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1323661005336 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1323661005337 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1323661005338 putative NAD(P) binding site [chemical binding]; other site 1323661005339 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1323661005340 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1323661005341 active site 1323661005342 PHP Thumb interface [polypeptide binding]; other site 1323661005343 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1323661005344 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 1323661005345 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1323661005346 generic binding surface I; other site 1323661005347 generic binding surface II; other site 1323661005348 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1323661005349 DHH family; Region: DHH; pfam01368 1323661005350 DHHA1 domain; Region: DHHA1; pfam02272 1323661005351 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1323661005352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1323661005353 DNA-binding site [nucleotide binding]; DNA binding site 1323661005354 DRTGG domain; Region: DRTGG; pfam07085 1323661005355 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1323661005356 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1323661005357 active site 2 [active] 1323661005358 active site 1 [active] 1323661005359 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1323661005360 Ligand Binding Site [chemical binding]; other site 1323661005361 metal-dependent hydrolase; Provisional; Region: PRK00685 1323661005362 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1323661005363 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1323661005364 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1323661005365 active site 1323661005366 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1323661005367 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1323661005368 hexamer interface [polypeptide binding]; other site 1323661005369 ligand binding site [chemical binding]; other site 1323661005370 putative active site [active] 1323661005371 NAD(P) binding site [chemical binding]; other site 1323661005372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1323661005373 Ligand Binding Site [chemical binding]; other site 1323661005374 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1323661005375 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1323661005376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661005377 S-adenosylmethionine binding site [chemical binding]; other site 1323661005378 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1323661005379 dimer interface [polypeptide binding]; other site 1323661005380 catalytic triad [active] 1323661005381 peroxidatic and resolving cysteines [active] 1323661005382 hypothetical protein; Provisional; Region: PRK10621 1323661005383 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1323661005384 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1323661005385 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1323661005386 Ligand Binding Site [chemical binding]; other site 1323661005387 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1323661005388 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1323661005389 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1323661005390 catalytic residue [active] 1323661005391 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1323661005392 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1323661005393 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1323661005394 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1323661005395 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1323661005396 RNA binding surface [nucleotide binding]; other site 1323661005397 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1323661005398 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1323661005399 active site 1323661005400 catalytic site [active] 1323661005401 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1323661005402 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1323661005403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1323661005404 catalytic residue [active] 1323661005405 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1323661005406 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1323661005407 ligand binding site [chemical binding]; other site 1323661005408 NAD binding site [chemical binding]; other site 1323661005409 dimerization interface [polypeptide binding]; other site 1323661005410 catalytic site [active] 1323661005411 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1323661005412 putative L-serine binding site [chemical binding]; other site 1323661005413 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1323661005414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661005415 motif II; other site 1323661005416 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1323661005417 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1323661005418 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1323661005419 active site turn [active] 1323661005420 phosphorylation site [posttranslational modification] 1323661005421 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1323661005422 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1323661005423 putative acyl-acceptor binding pocket; other site 1323661005424 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1323661005425 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1323661005426 protein binding site [polypeptide binding]; other site 1323661005427 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1323661005428 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1323661005429 active site 1323661005430 HIGH motif; other site 1323661005431 dimer interface [polypeptide binding]; other site 1323661005432 KMSKS motif; other site 1323661005433 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1323661005434 RNA binding surface [nucleotide binding]; other site 1323661005435 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1323661005436 Transglycosylase; Region: Transgly; pfam00912 1323661005437 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1323661005438 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1323661005439 NEAr Transporter domain; Region: NEAT; smart00725 1323661005440 NEAr Transporter domain; Region: NEAT; smart00725 1323661005441 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1323661005442 heme-binding site [chemical binding]; other site 1323661005443 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1323661005444 Potassium binding sites [ion binding]; other site 1323661005445 Cesium cation binding sites [ion binding]; other site 1323661005446 acetyl-CoA synthetase; Provisional; Region: PRK04319 1323661005447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1323661005448 acyl-activating enzyme (AAE) consensus motif; other site 1323661005449 AMP binding site [chemical binding]; other site 1323661005450 active site 1323661005451 CoA binding site [chemical binding]; other site 1323661005452 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1323661005453 active site 1323661005454 Zn binding site [ion binding]; other site 1323661005455 catabolite control protein A; Region: ccpA; TIGR01481 1323661005456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1323661005457 DNA binding site [nucleotide binding] 1323661005458 domain linker motif; other site 1323661005459 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1323661005460 dimerization interface [polypeptide binding]; other site 1323661005461 effector binding site; other site 1323661005462 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1323661005463 Chorismate mutase type II; Region: CM_2; cl00693 1323661005464 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1323661005465 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1323661005466 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1323661005467 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1323661005468 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1323661005469 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1323661005470 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1323661005471 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1323661005472 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1323661005473 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 1323661005474 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1323661005475 putative tRNA-binding site [nucleotide binding]; other site 1323661005476 hypothetical protein; Provisional; Region: PRK13668 1323661005477 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1323661005478 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1323661005479 catalytic residues [active] 1323661005480 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1323661005481 oligomer interface [polypeptide binding]; other site 1323661005482 active site 1323661005483 metal binding site [ion binding]; metal-binding site 1323661005484 Predicted small secreted protein [Function unknown]; Region: COG5584 1323661005485 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1323661005486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661005487 S-adenosylmethionine binding site [chemical binding]; other site 1323661005488 Phosphotransferase enzyme family; Region: APH; pfam01636 1323661005489 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1323661005490 active site 1323661005491 substrate binding site [chemical binding]; other site 1323661005492 ATP binding site [chemical binding]; other site 1323661005493 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1323661005494 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1323661005495 homodimer interface [polypeptide binding]; other site 1323661005496 substrate-cofactor binding pocket; other site 1323661005497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661005498 catalytic residue [active] 1323661005499 dipeptidase PepV; Reviewed; Region: PRK07318 1323661005500 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1323661005501 active site 1323661005502 metal binding site [ion binding]; metal-binding site 1323661005503 Hsp70 protein; Region: HSP70; pfam00012 1323661005504 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1323661005505 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1323661005506 RNA binding surface [nucleotide binding]; other site 1323661005507 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1323661005508 active site 1323661005509 uracil binding [chemical binding]; other site 1323661005510 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1323661005511 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1323661005512 HI0933-like protein; Region: HI0933_like; pfam03486 1323661005513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661005514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661005515 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661005516 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1323661005517 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005518 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005519 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005520 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005521 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005522 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005523 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005524 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005525 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005526 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005527 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005528 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005529 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005530 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005531 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005532 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661005533 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1323661005534 active site residue [active] 1323661005535 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1323661005536 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1323661005537 HIGH motif; other site 1323661005538 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1323661005539 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1323661005540 active site 1323661005541 KMSKS motif; other site 1323661005542 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1323661005543 tRNA binding surface [nucleotide binding]; other site 1323661005544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661005545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661005546 putative substrate translocation pore; other site 1323661005547 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1323661005548 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1323661005549 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1323661005550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661005551 S-adenosylmethionine binding site [chemical binding]; other site 1323661005552 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1323661005553 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1323661005554 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1323661005555 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1323661005556 Proline dehydrogenase; Region: Pro_dh; pfam01619 1323661005557 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1323661005558 homopentamer interface [polypeptide binding]; other site 1323661005559 active site 1323661005560 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1323661005561 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1323661005562 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1323661005563 dimerization interface [polypeptide binding]; other site 1323661005564 active site 1323661005565 Riboflavin synthase alpha chain [Coenzyme metabolism]; Region: RibC; COG0307 1323661005566 Lumazine binding domain; Region: Lum_binding; pfam00677 1323661005567 Lumazine binding domain; Region: Lum_binding; pfam00677 1323661005568 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1323661005569 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1323661005570 catalytic motif [active] 1323661005571 Zn binding site [ion binding]; other site 1323661005572 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1323661005573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1323661005574 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1323661005575 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1323661005576 arsenical pump membrane protein; Provisional; Region: PRK15445 1323661005577 transmembrane helices; other site 1323661005578 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1323661005579 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1323661005580 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1323661005581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1323661005582 DNA binding residues [nucleotide binding] 1323661005583 ComK protein; Region: ComK; cl11560 1323661005584 CAAX protease self-immunity; Region: Abi; pfam02517 1323661005585 CAAX protease self-immunity; Region: Abi; pfam02517 1323661005586 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1323661005587 active site 1323661005588 intersubunit interactions; other site 1323661005589 catalytic residue [active] 1323661005590 camphor resistance protein CrcB; Provisional; Region: PRK14201 1323661005591 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1323661005592 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1323661005593 active site 1323661005594 catalytic tetrad [active] 1323661005595 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1323661005596 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1323661005597 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1323661005598 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1323661005599 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1323661005600 active site 1323661005601 substrate-binding site [chemical binding]; other site 1323661005602 metal-binding site [ion binding] 1323661005603 ATP binding site [chemical binding]; other site 1323661005604 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1323661005605 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1323661005606 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1323661005607 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1323661005608 nudix motif; other site 1323661005609 Haemolytic domain; Region: Haemolytic; pfam01809 1323661005610 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1323661005611 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1323661005612 metal binding site [ion binding]; metal-binding site 1323661005613 substrate binding pocket [chemical binding]; other site 1323661005614 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1323661005615 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1323661005616 acyl-activating enzyme (AAE) consensus motif; other site 1323661005617 putative AMP binding site [chemical binding]; other site 1323661005618 putative active site [active] 1323661005619 putative CoA binding site [chemical binding]; other site 1323661005620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1323661005621 Transposase; Region: HTH_Tnp_1; cl17663 1323661005622 putative transposase OrfB; Reviewed; Region: PHA02517 1323661005623 HTH-like domain; Region: HTH_21; pfam13276 1323661005624 Integrase core domain; Region: rve; pfam00665 1323661005625 Integrase core domain; Region: rve_3; pfam13683 1323661005626 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1323661005627 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1323661005628 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1323661005629 putative transposase OrfB; Reviewed; Region: PHA02517 1323661005630 HTH-like domain; Region: HTH_21; pfam13276 1323661005631 Integrase core domain; Region: rve; pfam00665 1323661005632 Integrase core domain; Region: rve_3; pfam13683 1323661005633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1323661005634 Transposase; Region: HTH_Tnp_1; cl17663 1323661005635 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1323661005636 Family description; Region: UvrD_C_2; pfam13538 1323661005637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1323661005638 Transposase; Region: HTH_Tnp_1; cl17663 1323661005639 putative transposase OrfB; Reviewed; Region: PHA02517 1323661005640 HTH-like domain; Region: HTH_21; pfam13276 1323661005641 Integrase core domain; Region: rve; pfam00665 1323661005642 Integrase core domain; Region: rve_3; pfam13683 1323661005643 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1323661005644 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 1323661005645 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1323661005646 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661005647 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661005648 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1323661005649 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1323661005650 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661005651 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1323661005652 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661005653 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1323661005654 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661005655 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1323661005656 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1323661005657 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1323661005658 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1323661005659 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1323661005660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1323661005661 ferrochelatase; Provisional; Region: PRK12435 1323661005662 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1323661005663 C-terminal domain interface [polypeptide binding]; other site 1323661005664 active site 1323661005665 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1323661005666 active site 1323661005667 N-terminal domain interface [polypeptide binding]; other site 1323661005668 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1323661005669 substrate binding site [chemical binding]; other site 1323661005670 active site 1323661005671 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1323661005672 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1323661005673 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1323661005674 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1323661005675 Walker A/P-loop; other site 1323661005676 ATP binding site [chemical binding]; other site 1323661005677 Q-loop/lid; other site 1323661005678 ABC transporter signature motif; other site 1323661005679 Walker B; other site 1323661005680 D-loop; other site 1323661005681 H-loop/switch region; other site 1323661005682 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1323661005683 HIT family signature motif; other site 1323661005684 catalytic residue [active] 1323661005685 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1323661005686 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1323661005687 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1323661005688 SurA N-terminal domain; Region: SurA_N_3; cl07813 1323661005689 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1323661005690 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1323661005691 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1323661005692 generic binding surface II; other site 1323661005693 generic binding surface I; other site 1323661005694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1323661005695 Zn2+ binding site [ion binding]; other site 1323661005696 Mg2+ binding site [ion binding]; other site 1323661005697 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1323661005698 AAA domain; Region: AAA_23; pfam13476 1323661005699 Walker A/P-loop; other site 1323661005700 ATP binding site [chemical binding]; other site 1323661005701 Peptidase family M48; Region: Peptidase_M48; cl12018 1323661005702 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1323661005703 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1323661005704 active site 1323661005705 metal binding site [ion binding]; metal-binding site 1323661005706 DNA binding site [nucleotide binding] 1323661005707 hypothetical protein; Provisional; Region: PRK13676 1323661005708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1323661005709 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1323661005710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661005711 non-specific DNA binding site [nucleotide binding]; other site 1323661005712 salt bridge; other site 1323661005713 sequence-specific DNA binding site [nucleotide binding]; other site 1323661005714 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1323661005715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661005716 active site 1323661005717 phosphorylation site [posttranslational modification] 1323661005718 intermolecular recognition site; other site 1323661005719 dimerization interface [polypeptide binding]; other site 1323661005720 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1323661005721 DNA binding residues [nucleotide binding] 1323661005722 dimerization interface [polypeptide binding]; other site 1323661005723 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1323661005724 GAF domain; Region: GAF_3; pfam13492 1323661005725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1323661005726 Histidine kinase; Region: HisKA_3; pfam07730 1323661005727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661005728 ATP binding site [chemical binding]; other site 1323661005729 Mg2+ binding site [ion binding]; other site 1323661005730 G-X-G motif; other site 1323661005731 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1323661005732 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1323661005733 active site 1323661005734 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1323661005735 Class II fumarases; Region: Fumarase_classII; cd01362 1323661005736 active site 1323661005737 tetramer interface [polypeptide binding]; other site 1323661005738 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1323661005739 active site 1323661005740 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1323661005741 epoxyqueuosine reductase; Region: TIGR00276 1323661005742 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1323661005743 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1323661005744 HEAT-like repeat; Region: HEAT_EZ; pfam13513 1323661005745 HEAT repeats; Region: HEAT_2; pfam13646 1323661005746 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1323661005747 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1323661005748 Walker A/P-loop; other site 1323661005749 ATP binding site [chemical binding]; other site 1323661005750 Q-loop/lid; other site 1323661005751 ABC transporter signature motif; other site 1323661005752 Walker B; other site 1323661005753 D-loop; other site 1323661005754 H-loop/switch region; other site 1323661005755 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1323661005756 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1323661005757 substrate binding pocket [chemical binding]; other site 1323661005758 membrane-bound complex binding site; other site 1323661005759 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1323661005760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661005761 dimer interface [polypeptide binding]; other site 1323661005762 conserved gate region; other site 1323661005763 putative PBP binding loops; other site 1323661005764 ABC-ATPase subunit interface; other site 1323661005765 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1323661005766 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1323661005767 metal binding site 2 [ion binding]; metal-binding site 1323661005768 putative DNA binding helix; other site 1323661005769 metal binding site 1 [ion binding]; metal-binding site 1323661005770 dimer interface [polypeptide binding]; other site 1323661005771 structural Zn2+ binding site [ion binding]; other site 1323661005772 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1323661005773 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1323661005774 putative ligand binding site [chemical binding]; other site 1323661005775 NAD binding site [chemical binding]; other site 1323661005776 catalytic site [active] 1323661005777 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1323661005778 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1323661005779 catalytic triad [active] 1323661005780 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1323661005781 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1323661005782 inhibitor-cofactor binding pocket; inhibition site 1323661005783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661005784 catalytic residue [active] 1323661005785 Predicted membrane protein [Function unknown]; Region: COG4129 1323661005786 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1323661005787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1323661005788 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1323661005789 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1323661005790 Walker A/P-loop; other site 1323661005791 ATP binding site [chemical binding]; other site 1323661005792 Q-loop/lid; other site 1323661005793 ABC transporter signature motif; other site 1323661005794 Walker B; other site 1323661005795 D-loop; other site 1323661005796 H-loop/switch region; other site 1323661005797 hypothetical protein; Provisional; Region: PRK13662 1323661005798 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1323661005799 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1323661005800 minor groove reading motif; other site 1323661005801 helix-hairpin-helix signature motif; other site 1323661005802 substrate binding pocket [chemical binding]; other site 1323661005803 active site 1323661005804 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1323661005805 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1323661005806 DNA binding and oxoG recognition site [nucleotide binding] 1323661005807 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1323661005808 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1323661005809 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1323661005810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661005811 Walker A/P-loop; other site 1323661005812 ATP binding site [chemical binding]; other site 1323661005813 Q-loop/lid; other site 1323661005814 ABC transporter signature motif; other site 1323661005815 Walker B; other site 1323661005816 H-loop/switch region; other site 1323661005817 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1323661005818 recombination regulator RecX; Provisional; Region: recX; PRK14135 1323661005819 glycosyltransferase; Provisional; Region: PRK13481 1323661005820 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1323661005821 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1323661005822 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1323661005823 proposed catalytic triad [active] 1323661005824 conserved cys residue [active] 1323661005825 Protein of unknown function DUF16; Region: DUF16; pfam01519 1323661005826 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 1323661005827 CHAP domain; Region: CHAP; pfam05257 1323661005828 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1323661005829 amidase catalytic site [active] 1323661005830 Zn binding residues [ion binding]; other site 1323661005831 substrate binding site [chemical binding]; other site 1323661005832 Bacterial SH3 domain; Region: SH3_5; pfam08460 1323661005833 Bacteriophage holin; Region: Phage_holin_1; pfam04531 1323661005834 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1323661005835 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1323661005836 CHAP domain; Region: CHAP; pfam05257 1323661005837 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1323661005838 Lysozyme subfamily 2; Region: LYZ2; smart00047 1323661005839 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1323661005840 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1323661005841 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 1323661005842 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1323661005843 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1323661005844 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1323661005845 active site 1323661005846 catalytic triad [active] 1323661005847 oxyanion hole [active] 1323661005848 Phage tail protein; Region: Sipho_tail; pfam05709 1323661005849 PspA/IM30 family; Region: PspA_IM30; pfam04012 1323661005850 Phage-related protein [Function unknown]; Region: COG5412 1323661005851 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1323661005852 Phage protein; Region: DUF3647; pfam12363 1323661005853 Pyruvate formate lyase; Region: PFL; pfam02901 1323661005854 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1323661005855 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1323661005856 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1323661005857 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 1323661005858 Phage capsid family; Region: Phage_capsid; pfam05065 1323661005859 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1323661005860 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 1323661005861 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1323661005862 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1323661005863 Phage terminase large subunit; Region: Terminase_3; cl12054 1323661005864 Terminase-like family; Region: Terminase_6; pfam03237 1323661005865 Transcriptional activator RinB; Region: RinB; pfam06116 1323661005866 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1323661005867 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1323661005868 trimer interface [polypeptide binding]; other site 1323661005869 active site 1323661005870 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1323661005871 YopX protein; Region: YopX; pfam09643 1323661005872 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1323661005873 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1323661005874 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1323661005875 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1323661005876 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1323661005877 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1323661005878 dimer interface [polypeptide binding]; other site 1323661005879 ssDNA binding site [nucleotide binding]; other site 1323661005880 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1323661005881 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1323661005882 RecT family; Region: RecT; pfam03837 1323661005883 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1323661005884 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1323661005885 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 1323661005886 Prophage antirepressor [Transcription]; Region: COG3617 1323661005887 BRO family, N-terminal domain; Region: Bro-N; smart01040 1323661005888 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1323661005889 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1323661005890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1323661005891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661005892 non-specific DNA binding site [nucleotide binding]; other site 1323661005893 salt bridge; other site 1323661005894 sequence-specific DNA binding site [nucleotide binding]; other site 1323661005895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1323661005896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661005897 non-specific DNA binding site [nucleotide binding]; other site 1323661005898 salt bridge; other site 1323661005899 sequence-specific DNA binding site [nucleotide binding]; other site 1323661005900 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1323661005901 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1323661005902 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1323661005903 Int/Topo IB signature motif; other site 1323661005904 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1323661005905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661005906 FeS/SAM binding site; other site 1323661005907 YfkB-like domain; Region: YfkB; pfam08756 1323661005908 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1323661005909 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1323661005910 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1323661005911 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1323661005912 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1323661005913 active site 1323661005914 YtxH-like protein; Region: YtxH; pfam12732 1323661005915 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1323661005916 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1323661005917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661005918 active site 1323661005919 phosphorylation site [posttranslational modification] 1323661005920 intermolecular recognition site; other site 1323661005921 dimerization interface [polypeptide binding]; other site 1323661005922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1323661005923 DNA binding residues [nucleotide binding] 1323661005924 dimerization interface [polypeptide binding]; other site 1323661005925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1323661005926 Histidine kinase; Region: HisKA_3; pfam07730 1323661005927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661005928 ATP binding site [chemical binding]; other site 1323661005929 Mg2+ binding site [ion binding]; other site 1323661005930 G-X-G motif; other site 1323661005931 Predicted membrane protein [Function unknown]; Region: COG4758 1323661005932 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1323661005933 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1323661005934 active site 1323661005935 Predicted membrane protein [Function unknown]; Region: COG4129 1323661005936 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1323661005937 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1323661005938 catalytic triad [active] 1323661005939 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1323661005940 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1323661005941 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1323661005942 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1323661005943 Ferritin-like domain; Region: Ferritin; pfam00210 1323661005944 ferroxidase diiron center [ion binding]; other site 1323661005945 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1323661005946 active site 1323661005947 catalytic site [active] 1323661005948 substrate binding site [chemical binding]; other site 1323661005949 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1323661005950 active site 1323661005951 DNA polymerase IV; Validated; Region: PRK02406 1323661005952 DNA binding site [nucleotide binding] 1323661005953 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1323661005954 TRAM domain; Region: TRAM; cl01282 1323661005955 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1323661005956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661005957 S-adenosylmethionine binding site [chemical binding]; other site 1323661005958 putative lipid kinase; Reviewed; Region: PRK13337 1323661005959 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1323661005960 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1323661005961 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1323661005962 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1323661005963 GatB domain; Region: GatB_Yqey; pfam02637 1323661005964 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1323661005965 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1323661005966 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1323661005967 Na binding site [ion binding]; other site 1323661005968 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1323661005969 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1323661005970 putative dimer interface [polypeptide binding]; other site 1323661005971 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1323661005972 putative dimer interface [polypeptide binding]; other site 1323661005973 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1323661005974 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1323661005975 nucleotide binding pocket [chemical binding]; other site 1323661005976 K-X-D-G motif; other site 1323661005977 catalytic site [active] 1323661005978 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1323661005979 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1323661005980 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1323661005981 Dimer interface [polypeptide binding]; other site 1323661005982 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1323661005983 Part of AAA domain; Region: AAA_19; pfam13245 1323661005984 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 1323661005985 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1323661005986 substrate binding site [chemical binding]; other site 1323661005987 putative active site [active] 1323661005988 dimer interface [polypeptide binding]; other site 1323661005989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1323661005990 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1323661005991 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1323661005992 tetramer interface [polypeptide binding]; other site 1323661005993 active site 1323661005994 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1323661005995 Staphopain proregion; Region: Staphopain_pro; pfam14731 1323661005996 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1323661005997 Staphostatin A; Region: Staphostatin_A; pfam09022 1323661005998 NETI protein; Region: NETI; pfam14044 1323661005999 hypothetical protein; Provisional; Region: PRK04164 1323661006000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1323661006001 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1323661006002 homodimer interface [polypeptide binding]; other site 1323661006003 NAD binding pocket [chemical binding]; other site 1323661006004 ATP binding pocket [chemical binding]; other site 1323661006005 Mg binding site [ion binding]; other site 1323661006006 active-site loop [active] 1323661006007 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1323661006008 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1323661006009 active site 1323661006010 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1323661006011 active site 1323661006012 dimer interface [polypeptide binding]; other site 1323661006013 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1323661006014 Prephenate dehydratase; Region: PDT; pfam00800 1323661006015 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1323661006016 putative L-Phe binding site [chemical binding]; other site 1323661006017 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1323661006018 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1323661006019 transmembrane helices; other site 1323661006020 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1323661006021 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1323661006022 Isochorismatase family; Region: Isochorismatase; pfam00857 1323661006023 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1323661006024 catalytic triad [active] 1323661006025 conserved cis-peptide bond; other site 1323661006026 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1323661006027 DHH family; Region: DHH; pfam01368 1323661006028 DHHA2 domain; Region: DHHA2; pfam02833 1323661006029 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1323661006030 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1323661006031 NAD(P) binding site [chemical binding]; other site 1323661006032 catalytic residues [active] 1323661006033 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1323661006034 YolD-like protein; Region: YolD; pfam08863 1323661006035 Predicted choloylglycine hydrolase [General function prediction only]; Region: COG4927 1323661006036 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1323661006037 active site 1323661006038 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1323661006039 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1323661006040 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1323661006041 Bacterial PH domain; Region: bPH_2; cl01348 1323661006042 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 1323661006043 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1323661006044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661006045 Walker A/P-loop; other site 1323661006046 ATP binding site [chemical binding]; other site 1323661006047 Q-loop/lid; other site 1323661006048 ABC transporter signature motif; other site 1323661006049 Walker B; other site 1323661006050 D-loop; other site 1323661006051 H-loop/switch region; other site 1323661006052 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1323661006053 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1323661006054 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1323661006055 Walker A/P-loop; other site 1323661006056 ATP binding site [chemical binding]; other site 1323661006057 Q-loop/lid; other site 1323661006058 ABC transporter signature motif; other site 1323661006059 Walker B; other site 1323661006060 D-loop; other site 1323661006061 H-loop/switch region; other site 1323661006062 Predicted transcriptional regulators [Transcription]; Region: COG1725 1323661006063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1323661006064 DNA-binding site [nucleotide binding]; DNA binding site 1323661006065 hypothetical protein; Provisional; Region: PRK08637 1323661006066 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1323661006067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661006068 homodimer interface [polypeptide binding]; other site 1323661006069 catalytic residue [active] 1323661006070 MAP domain; Region: MAP; pfam03642 1323661006071 MAP domain; Region: MAP; pfam03642 1323661006072 MAP domain; Region: MAP; pfam03642 1323661006073 MAP domain; Region: MAP; pfam03642 1323661006074 MAP domain; Region: MAP; pfam03642 1323661006075 MAP domain; Region: MAP; pfam03642 1323661006076 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1323661006077 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1323661006078 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 1323661006079 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1323661006080 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 1323661006081 CHAP domain; Region: CHAP; pfam05257 1323661006082 Small integral membrane protein [Function unknown]; Region: COG5546 1323661006083 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1323661006084 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 1323661006085 TolA protein; Region: tolA_full; TIGR02794 1323661006086 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1323661006087 Phage tail protein; Region: Sipho_tail; cl17486 1323661006088 Phage tail protein; Region: Sipho_tail; cl17486 1323661006089 Phage-related minor tail protein [Function unknown]; Region: COG5280 1323661006090 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1323661006091 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 1323661006092 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1323661006093 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1323661006094 Phage-related protein [Function unknown]; Region: COG5412 1323661006095 membrane protein P6; Region: PHA01399 1323661006096 Peptidase family M23; Region: Peptidase_M23; pfam01551 1323661006097 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1323661006098 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1323661006099 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1323661006100 catalytic residue [active] 1323661006101 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1323661006102 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1323661006103 Translocation protein Sec62; Region: Sec62; cl02170 1323661006104 Phage capsid family; Region: Phage_capsid; pfam05065 1323661006105 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1323661006106 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1323661006107 oligomer interface [polypeptide binding]; other site 1323661006108 active site residues [active] 1323661006109 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1323661006110 putative transposase OrfB; Reviewed; Region: PHA02517 1323661006111 HTH-like domain; Region: HTH_21; pfam13276 1323661006112 Integrase core domain; Region: rve; pfam00665 1323661006113 Integrase core domain; Region: rve_3; pfam13683 1323661006114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1323661006115 Transposase; Region: HTH_Tnp_1; cl17663 1323661006116 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1323661006117 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1323661006118 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1323661006119 HNH endonuclease; Region: HNH; pfam01844 1323661006120 active site 1323661006121 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1323661006122 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1323661006123 Transcriptional activator RinB; Region: RinB; pfam06116 1323661006124 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1323661006125 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1323661006126 dUTPase; Region: dUTPase_2; pfam08761 1323661006127 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1323661006128 active site 1323661006129 homodimer interface [polypeptide binding]; other site 1323661006130 metal binding site [ion binding]; metal-binding site 1323661006131 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1323661006132 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1323661006133 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1323661006134 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1323661006135 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1323661006136 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1323661006137 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1323661006138 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1323661006139 dimer interface [polypeptide binding]; other site 1323661006140 ssDNA binding site [nucleotide binding]; other site 1323661006141 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1323661006142 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1323661006143 RecT family; Region: RecT; pfam03837 1323661006144 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1323661006145 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1323661006146 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 1323661006147 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 1323661006148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 1323661006149 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 1323661006150 Phage anti-repressor protein [Transcription]; Region: COG3561 1323661006151 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1323661006152 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1323661006153 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1323661006154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661006155 non-specific DNA binding site [nucleotide binding]; other site 1323661006156 salt bridge; other site 1323661006157 sequence-specific DNA binding site [nucleotide binding]; other site 1323661006158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661006159 non-specific DNA binding site [nucleotide binding]; other site 1323661006160 salt bridge; other site 1323661006161 sequence-specific DNA binding site [nucleotide binding]; other site 1323661006162 Predicted transcriptional regulator [Transcription]; Region: COG2932 1323661006163 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1323661006164 Catalytic site [active] 1323661006165 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1323661006166 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1323661006167 active site 1323661006168 catalytic site [active] 1323661006169 substrate binding site [chemical binding]; other site 1323661006170 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1323661006171 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 1323661006172 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1323661006173 Int/Topo IB signature motif; other site 1323661006174 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1323661006175 putative catalytic site [active] 1323661006176 phosphate binding site [ion binding]; other site 1323661006177 metal binding site A [ion binding]; metal-binding site 1323661006178 metal binding site C [ion binding]; metal-binding site 1323661006179 metal binding site B [ion binding]; metal-binding site 1323661006180 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1323661006181 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1323661006182 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1323661006183 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1323661006184 metal binding site [ion binding]; metal-binding site 1323661006185 dimer interface [polypeptide binding]; other site 1323661006186 Cation transport protein; Region: TrkH; cl17365 1323661006187 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1323661006188 Cation transport protein; Region: TrkH; cl17365 1323661006189 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 1323661006190 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1323661006191 ring oligomerisation interface [polypeptide binding]; other site 1323661006192 ATP/Mg binding site [chemical binding]; other site 1323661006193 stacking interactions; other site 1323661006194 hinge regions; other site 1323661006195 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1323661006196 oligomerisation interface [polypeptide binding]; other site 1323661006197 mobile loop; other site 1323661006198 roof hairpin; other site 1323661006199 CAAX protease self-immunity; Region: Abi; pfam02517 1323661006200 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1323661006201 dimer interface [polypeptide binding]; other site 1323661006202 FMN binding site [chemical binding]; other site 1323661006203 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1323661006204 putative active site [active] 1323661006205 catalytic triad [active] 1323661006206 putative dimer interface [polypeptide binding]; other site 1323661006207 delta-hemolysin; Provisional; Region: PRK14752 1323661006208 Accessory gene regulator B; Region: AgrB; smart00793 1323661006209 Staphylococcal AgrD protein; Region: AgrD; smart00794 1323661006210 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1323661006211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661006212 Mg2+ binding site [ion binding]; other site 1323661006213 G-X-G motif; other site 1323661006214 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1323661006215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661006216 active site 1323661006217 phosphorylation site [posttranslational modification] 1323661006218 intermolecular recognition site; other site 1323661006219 dimerization interface [polypeptide binding]; other site 1323661006220 LytTr DNA-binding domain; Region: LytTR; pfam04397 1323661006221 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1323661006222 putative substrate binding site [chemical binding]; other site 1323661006223 putative ATP binding site [chemical binding]; other site 1323661006224 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1323661006225 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1323661006226 substrate binding [chemical binding]; other site 1323661006227 active site 1323661006228 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1323661006229 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1323661006230 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1323661006231 DNA binding site [nucleotide binding] 1323661006232 domain linker motif; other site 1323661006233 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1323661006234 dimerization interface [polypeptide binding]; other site 1323661006235 ligand binding site [chemical binding]; other site 1323661006236 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1323661006237 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1323661006238 CPxP motif; other site 1323661006239 Predicted transporter component [General function prediction only]; Region: COG2391 1323661006240 Sulphur transport; Region: Sulf_transp; cl19477 1323661006241 Sulphur transport; Region: Sulf_transp; cl19477 1323661006242 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1323661006243 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1323661006244 CoA binding domain; Region: CoA_binding; pfam02629 1323661006245 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1323661006246 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1323661006247 ABC transporter; Region: ABC_tran_2; pfam12848 1323661006248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1323661006249 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1323661006250 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 1323661006251 Walker A/P-loop; other site 1323661006252 ATP binding site [chemical binding]; other site 1323661006253 Q-loop/lid; other site 1323661006254 ABC transporter signature motif; other site 1323661006255 Walker B; other site 1323661006256 D-loop; other site 1323661006257 H-loop/switch region; other site 1323661006258 UGMP family protein; Validated; Region: PRK09604 1323661006259 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1323661006260 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1323661006261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661006262 Coenzyme A binding pocket [chemical binding]; other site 1323661006263 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1323661006264 Glycoprotease family; Region: Peptidase_M22; pfam00814 1323661006265 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1323661006266 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1323661006267 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1323661006268 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 1323661006269 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1323661006270 PYR/PP interface [polypeptide binding]; other site 1323661006271 dimer interface [polypeptide binding]; other site 1323661006272 TPP binding site [chemical binding]; other site 1323661006273 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1323661006274 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1323661006275 TPP-binding site [chemical binding]; other site 1323661006276 dimer interface [polypeptide binding]; other site 1323661006277 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 1323661006278 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1323661006279 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1323661006280 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1323661006281 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1323661006282 2-isopropylmalate synthase; Validated; Region: PRK00915 1323661006283 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1323661006284 active site 1323661006285 catalytic residues [active] 1323661006286 metal binding site [ion binding]; metal-binding site 1323661006287 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 1323661006288 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1323661006289 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1323661006290 substrate binding site [chemical binding]; other site 1323661006291 ligand binding site [chemical binding]; other site 1323661006292 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1323661006293 substrate binding site [chemical binding]; other site 1323661006294 threonine dehydratase; Validated; Region: PRK08639 1323661006295 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1323661006296 tetramer interface [polypeptide binding]; other site 1323661006297 catalytic residue [active] 1323661006298 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1323661006299 putative Ile/Val binding site [chemical binding]; other site 1323661006300 hypothetical protein; Provisional; Region: PRK04351 1323661006301 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1323661006302 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1323661006303 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1323661006304 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1323661006305 Death-like domain of SPT6; Region: DLD; pfam14878 1323661006306 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1323661006307 RNA binding site [nucleotide binding]; other site 1323661006308 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1323661006309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1323661006310 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1323661006311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1323661006312 DNA binding residues [nucleotide binding] 1323661006313 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1323661006314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661006315 ATP binding site [chemical binding]; other site 1323661006316 Mg2+ binding site [ion binding]; other site 1323661006317 G-X-G motif; other site 1323661006318 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1323661006319 anti sigma factor interaction site; other site 1323661006320 regulatory phosphorylation site [posttranslational modification]; other site 1323661006321 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1323661006322 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1323661006323 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1323661006324 PemK-like protein; Region: PemK; pfam02452 1323661006325 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1323661006326 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1323661006327 active site 1323661006328 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1323661006329 dimer interface [polypeptide binding]; other site 1323661006330 substrate binding site [chemical binding]; other site 1323661006331 catalytic residues [active] 1323661006332 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1323661006333 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1323661006334 Predicted membrane protein [Function unknown]; Region: COG3428 1323661006335 Bacterial PH domain; Region: bPH_2; pfam03703 1323661006336 Bacterial PH domain; Region: bPH_2; pfam03703 1323661006337 Bacterial PH domain; Region: bPH_2; cl01348 1323661006338 Bacterial PH domain; Region: bPH_2; cl01348 1323661006339 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1323661006340 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1323661006341 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1323661006342 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1323661006343 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1323661006344 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1323661006345 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1323661006346 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1323661006347 Ligand Binding Site [chemical binding]; other site 1323661006348 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1323661006349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1323661006350 dimer interface [polypeptide binding]; other site 1323661006351 phosphorylation site [posttranslational modification] 1323661006352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661006353 ATP binding site [chemical binding]; other site 1323661006354 Mg2+ binding site [ion binding]; other site 1323661006355 G-X-G motif; other site 1323661006356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661006357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661006358 active site 1323661006359 phosphorylation site [posttranslational modification] 1323661006360 intermolecular recognition site; other site 1323661006361 dimerization interface [polypeptide binding]; other site 1323661006362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661006363 DNA binding site [nucleotide binding] 1323661006364 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1323661006365 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1323661006366 ATP binding site [chemical binding]; other site 1323661006367 Mg++ binding site [ion binding]; other site 1323661006368 motif III; other site 1323661006369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661006370 nucleotide binding region [chemical binding]; other site 1323661006371 ATP-binding site [chemical binding]; other site 1323661006372 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1323661006373 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1323661006374 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1323661006375 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1323661006376 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1323661006377 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1323661006378 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1323661006379 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1323661006380 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1323661006381 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1323661006382 putative homodimer interface [polypeptide binding]; other site 1323661006383 putative homotetramer interface [polypeptide binding]; other site 1323661006384 allosteric switch controlling residues; other site 1323661006385 putative metal binding site [ion binding]; other site 1323661006386 putative homodimer-homodimer interface [polypeptide binding]; other site 1323661006387 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1323661006388 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1323661006389 putative active site [active] 1323661006390 catalytic site [active] 1323661006391 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1323661006392 putative active site [active] 1323661006393 catalytic site [active] 1323661006394 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1323661006395 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1323661006396 Zn2+ binding site [ion binding]; other site 1323661006397 Mg2+ binding site [ion binding]; other site 1323661006398 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1323661006399 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1323661006400 thiamine phosphate binding site [chemical binding]; other site 1323661006401 active site 1323661006402 pyrophosphate binding site [ion binding]; other site 1323661006403 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1323661006404 substrate binding site [chemical binding]; other site 1323661006405 multimerization interface [polypeptide binding]; other site 1323661006406 ATP binding site [chemical binding]; other site 1323661006407 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1323661006408 dimer interface [polypeptide binding]; other site 1323661006409 substrate binding site [chemical binding]; other site 1323661006410 ATP binding site [chemical binding]; other site 1323661006411 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1323661006412 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1323661006413 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1323661006414 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1323661006415 dimer interface [polypeptide binding]; other site 1323661006416 ssDNA binding site [nucleotide binding]; other site 1323661006417 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1323661006418 YwpF-like protein; Region: YwpF; pfam14183 1323661006419 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1323661006420 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 1323661006421 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1323661006422 hinge; other site 1323661006423 active site 1323661006424 Predicted membrane protein [Function unknown]; Region: COG4836 1323661006425 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1323661006426 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1323661006427 gamma subunit interface [polypeptide binding]; other site 1323661006428 epsilon subunit interface [polypeptide binding]; other site 1323661006429 LBP interface [polypeptide binding]; other site 1323661006430 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1323661006431 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1323661006432 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1323661006433 alpha subunit interaction interface [polypeptide binding]; other site 1323661006434 Walker A motif; other site 1323661006435 ATP binding site [chemical binding]; other site 1323661006436 Walker B motif; other site 1323661006437 inhibitor binding site; inhibition site 1323661006438 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1323661006439 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1323661006440 core domain interface [polypeptide binding]; other site 1323661006441 delta subunit interface [polypeptide binding]; other site 1323661006442 epsilon subunit interface [polypeptide binding]; other site 1323661006443 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1323661006444 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1323661006445 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1323661006446 beta subunit interaction interface [polypeptide binding]; other site 1323661006447 Walker A motif; other site 1323661006448 ATP binding site [chemical binding]; other site 1323661006449 Walker B motif; other site 1323661006450 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1323661006451 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1323661006452 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1323661006453 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1323661006454 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1323661006455 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1323661006456 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1323661006457 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1323661006458 active site 1323661006459 homodimer interface [polypeptide binding]; other site 1323661006460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1323661006461 active site 1323661006462 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1323661006463 dimer interface [polypeptide binding]; other site 1323661006464 active site 1323661006465 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1323661006466 folate binding site [chemical binding]; other site 1323661006467 hypothetical protein; Provisional; Region: PRK13690 1323661006468 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1323661006469 active site 1323661006470 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1323661006471 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1323661006472 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1323661006473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661006474 S-adenosylmethionine binding site [chemical binding]; other site 1323661006475 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1323661006476 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1323661006477 RF-1 domain; Region: RF-1; pfam00472 1323661006478 thymidine kinase; Provisional; Region: PRK04296 1323661006479 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1323661006480 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1323661006481 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1323661006482 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1323661006483 RNA binding site [nucleotide binding]; other site 1323661006484 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1323661006485 multimer interface [polypeptide binding]; other site 1323661006486 Walker A motif; other site 1323661006487 ATP binding site [chemical binding]; other site 1323661006488 Walker B motif; other site 1323661006489 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1323661006490 NAD binding site [chemical binding]; other site 1323661006491 catalytic residues [active] 1323661006492 Predicted transcriptional regulators [Transcription]; Region: COG1733 1323661006493 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1323661006494 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 1323661006495 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1323661006496 hinge; other site 1323661006497 active site 1323661006498 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1323661006499 intersubunit interface [polypeptide binding]; other site 1323661006500 active site 1323661006501 zinc binding site [ion binding]; other site 1323661006502 Na+ binding site [ion binding]; other site 1323661006503 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1323661006504 CTP synthetase; Validated; Region: pyrG; PRK05380 1323661006505 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1323661006506 Catalytic site [active] 1323661006507 active site 1323661006508 UTP binding site [chemical binding]; other site 1323661006509 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1323661006510 active site 1323661006511 putative oxyanion hole; other site 1323661006512 catalytic triad [active] 1323661006513 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343 1323661006514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661006515 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1323661006516 Coenzyme A binding pocket [chemical binding]; other site 1323661006517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1323661006518 pantothenate kinase; Provisional; Region: PRK13317 1323661006519 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1323661006520 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1323661006521 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1323661006522 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1323661006523 metal binding site [ion binding]; metal-binding site 1323661006524 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1323661006525 Predicted membrane protein [Function unknown]; Region: COG4270 1323661006526 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1323661006527 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1323661006528 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1323661006529 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1323661006530 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1323661006531 intersubunit interface [polypeptide binding]; other site 1323661006532 active site 1323661006533 catalytic residue [active] 1323661006534 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1323661006535 Ferritin-like domain; Region: Ferritin; pfam00210 1323661006536 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1323661006537 dimerization interface [polypeptide binding]; other site 1323661006538 DPS ferroxidase diiron center [ion binding]; other site 1323661006539 ion pore; other site 1323661006540 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1323661006541 EVE domain; Region: EVE; pfam01878 1323661006542 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1323661006543 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 1323661006544 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1323661006545 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1323661006546 NAD(P) binding site [chemical binding]; other site 1323661006547 putative active site [active] 1323661006548 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1323661006549 dimerization interface [polypeptide binding]; other site 1323661006550 putative DNA binding site [nucleotide binding]; other site 1323661006551 putative Zn2+ binding site [ion binding]; other site 1323661006552 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1323661006553 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1323661006554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661006555 active site 1323661006556 motif I; other site 1323661006557 motif II; other site 1323661006558 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1323661006559 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1323661006560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661006561 Walker A/P-loop; other site 1323661006562 ATP binding site [chemical binding]; other site 1323661006563 Q-loop/lid; other site 1323661006564 ABC transporter signature motif; other site 1323661006565 Walker B; other site 1323661006566 D-loop; other site 1323661006567 H-loop/switch region; other site 1323661006568 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1323661006569 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1323661006570 glutaminase active site [active] 1323661006571 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1323661006572 dimer interface [polypeptide binding]; other site 1323661006573 active site 1323661006574 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1323661006575 dimer interface [polypeptide binding]; other site 1323661006576 active site 1323661006577 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1323661006578 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1323661006579 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1323661006580 active site 1323661006581 P-loop; other site 1323661006582 phosphorylation site [posttranslational modification] 1323661006583 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1323661006584 Mga helix-turn-helix domain; Region: Mga; pfam05043 1323661006585 Mga helix-turn-helix domain; Region: Mga; pfam05043 1323661006586 PRD domain; Region: PRD; pfam00874 1323661006587 PRD domain; Region: PRD; pfam00874 1323661006588 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1323661006589 active site 1323661006590 P-loop; other site 1323661006591 phosphorylation site [posttranslational modification] 1323661006592 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1323661006593 active site 1323661006594 phosphorylation site [posttranslational modification] 1323661006595 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1323661006596 active site 1323661006597 phosphorylation site [posttranslational modification] 1323661006598 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1323661006599 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1323661006600 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1323661006601 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661006602 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1323661006603 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661006604 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661006605 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661006606 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661006607 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661006608 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661006609 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1323661006610 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1323661006611 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1323661006612 active site 1323661006613 substrate binding site [chemical binding]; other site 1323661006614 metal binding site [ion binding]; metal-binding site 1323661006615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1323661006616 YbbR-like protein; Region: YbbR; pfam07949 1323661006617 YbbR-like protein; Region: YbbR; pfam07949 1323661006618 TIGR00159 family protein; Region: TIGR00159 1323661006619 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1323661006620 Arginase family; Region: Arginase; cd09989 1323661006621 active site 1323661006622 Mn binding site [ion binding]; other site 1323661006623 oligomer interface [polypeptide binding]; other site 1323661006624 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1323661006625 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1323661006626 Walker A motif; other site 1323661006627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661006628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661006629 putative substrate translocation pore; other site 1323661006630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661006631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661006632 putative substrate translocation pore; other site 1323661006633 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1323661006634 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1323661006635 substrate binding site; other site 1323661006636 dimerization interface; other site 1323661006637 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1323661006638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1323661006639 Nucleoside recognition; Region: Gate; pfam07670 1323661006640 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1323661006641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661006642 ABC-ATPase subunit interface; other site 1323661006643 dimer interface [polypeptide binding]; other site 1323661006644 putative PBP binding regions; other site 1323661006645 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1323661006646 ABC-ATPase subunit interface; other site 1323661006647 dimer interface [polypeptide binding]; other site 1323661006648 putative PBP binding regions; other site 1323661006649 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1323661006650 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1323661006651 siderophore binding site; other site 1323661006652 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1323661006653 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1323661006654 dimer interface [polypeptide binding]; other site 1323661006655 active site 1323661006656 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1323661006657 substrate binding site [chemical binding]; other site 1323661006658 catalytic residue [active] 1323661006659 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1323661006660 IucA / IucC family; Region: IucA_IucC; pfam04183 1323661006661 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1323661006662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661006663 putative substrate translocation pore; other site 1323661006664 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1323661006665 IucA / IucC family; Region: IucA_IucC; pfam04183 1323661006666 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1323661006667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1323661006668 Small integral membrane protein [Function unknown]; Region: COG5547 1323661006669 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1323661006670 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1323661006671 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1323661006672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1323661006673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1323661006674 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1323661006675 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1323661006676 putative NAD(P) binding site [chemical binding]; other site 1323661006677 dimer interface [polypeptide binding]; other site 1323661006678 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1323661006679 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1323661006680 NAD(P) binding site [chemical binding]; other site 1323661006681 substrate binding site [chemical binding]; other site 1323661006682 dimer interface [polypeptide binding]; other site 1323661006683 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1323661006684 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1323661006685 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1323661006686 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1323661006687 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1323661006688 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1323661006689 active site 1323661006690 P-loop; other site 1323661006691 phosphorylation site [posttranslational modification] 1323661006692 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1323661006693 methionine cluster; other site 1323661006694 active site 1323661006695 phosphorylation site [posttranslational modification] 1323661006696 metal binding site [ion binding]; metal-binding site 1323661006697 tagatose 1,6-diphosphate aldolase; Region: lacD; TIGR01232 1323661006698 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1323661006699 putative substrate binding site [chemical binding]; other site 1323661006700 putative ATP binding site [chemical binding]; other site 1323661006701 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1323661006702 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1323661006703 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1323661006704 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1323661006705 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1323661006706 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1323661006707 NAD+ binding site [chemical binding]; other site 1323661006708 substrate binding site [chemical binding]; other site 1323661006709 putative Zn binding site [ion binding]; other site 1323661006710 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1323661006711 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1323661006712 active site 1323661006713 catalytic tetrad [active] 1323661006714 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1323661006715 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1323661006716 DNA binding residues [nucleotide binding] 1323661006717 putative dimer interface [polypeptide binding]; other site 1323661006718 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1323661006719 substrate binding site [chemical binding]; other site 1323661006720 catalytic residues [active] 1323661006721 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1323661006722 Peptidase family M23; Region: Peptidase_M23; pfam01551 1323661006723 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1323661006724 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1323661006725 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1323661006726 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1323661006727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661006728 active site 1323661006729 motif I; other site 1323661006730 motif II; other site 1323661006731 MAP domain; Region: MAP; pfam03642 1323661006732 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1323661006733 acetolactate synthase; Reviewed; Region: PRK08617 1323661006734 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1323661006735 PYR/PP interface [polypeptide binding]; other site 1323661006736 dimer interface [polypeptide binding]; other site 1323661006737 TPP binding site [chemical binding]; other site 1323661006738 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1323661006739 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1323661006740 TPP-binding site [chemical binding]; other site 1323661006741 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1323661006742 Divergent AAA domain; Region: AAA_4; pfam04326 1323661006743 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1323661006744 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1323661006745 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1323661006746 23S rRNA interface [nucleotide binding]; other site 1323661006747 L3 interface [polypeptide binding]; other site 1323661006748 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1323661006749 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1323661006750 dimerization interface 3.5A [polypeptide binding]; other site 1323661006751 active site 1323661006752 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1323661006753 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1323661006754 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1323661006755 Walker A/P-loop; other site 1323661006756 ATP binding site [chemical binding]; other site 1323661006757 Q-loop/lid; other site 1323661006758 ABC transporter signature motif; other site 1323661006759 Walker B; other site 1323661006760 D-loop; other site 1323661006761 H-loop/switch region; other site 1323661006762 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1323661006763 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1323661006764 Walker A/P-loop; other site 1323661006765 ATP binding site [chemical binding]; other site 1323661006766 Q-loop/lid; other site 1323661006767 ABC transporter signature motif; other site 1323661006768 Walker B; other site 1323661006769 D-loop; other site 1323661006770 H-loop/switch region; other site 1323661006771 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1323661006772 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1323661006773 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1323661006774 alphaNTD homodimer interface [polypeptide binding]; other site 1323661006775 alphaNTD - beta interaction site [polypeptide binding]; other site 1323661006776 alphaNTD - beta' interaction site [polypeptide binding]; other site 1323661006777 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1323661006778 30S ribosomal protein S11; Validated; Region: PRK05309 1323661006779 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1323661006780 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1323661006781 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1323661006782 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1323661006783 rRNA binding site [nucleotide binding]; other site 1323661006784 predicted 30S ribosome binding site; other site 1323661006785 adenylate kinase; Reviewed; Region: adk; PRK00279 1323661006786 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1323661006787 AMP-binding site [chemical binding]; other site 1323661006788 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1323661006789 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1323661006790 SecY translocase; Region: SecY; pfam00344 1323661006791 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1323661006792 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1323661006793 23S rRNA binding site [nucleotide binding]; other site 1323661006794 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1323661006795 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1323661006796 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1323661006797 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1323661006798 5S rRNA interface [nucleotide binding]; other site 1323661006799 L27 interface [polypeptide binding]; other site 1323661006800 23S rRNA interface [nucleotide binding]; other site 1323661006801 L5 interface [polypeptide binding]; other site 1323661006802 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1323661006803 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1323661006804 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1323661006805 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1323661006806 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1323661006807 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1323661006808 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1323661006809 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1323661006810 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1323661006811 RNA binding site [nucleotide binding]; other site 1323661006812 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1323661006813 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1323661006814 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1323661006815 23S rRNA interface [nucleotide binding]; other site 1323661006816 putative translocon interaction site; other site 1323661006817 signal recognition particle (SRP54) interaction site; other site 1323661006818 L23 interface [polypeptide binding]; other site 1323661006819 trigger factor interaction site; other site 1323661006820 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1323661006821 23S rRNA interface [nucleotide binding]; other site 1323661006822 5S rRNA interface [nucleotide binding]; other site 1323661006823 putative antibiotic binding site [chemical binding]; other site 1323661006824 L25 interface [polypeptide binding]; other site 1323661006825 L27 interface [polypeptide binding]; other site 1323661006826 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1323661006827 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1323661006828 G-X-X-G motif; other site 1323661006829 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1323661006830 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1323661006831 putative translocon binding site; other site 1323661006832 protein-rRNA interface [nucleotide binding]; other site 1323661006833 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1323661006834 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1323661006835 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1323661006836 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1323661006837 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1323661006838 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1323661006839 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1323661006840 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1323661006841 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1323661006842 Sulfate transporter family; Region: Sulfate_transp; cl19250 1323661006843 DNA topoisomerase III; Provisional; Region: PRK07726 1323661006844 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1323661006845 active site 1323661006846 putative interdomain interaction site [polypeptide binding]; other site 1323661006847 putative metal-binding site [ion binding]; other site 1323661006848 putative nucleotide binding site [chemical binding]; other site 1323661006849 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1323661006850 domain I; other site 1323661006851 DNA binding groove [nucleotide binding] 1323661006852 phosphate binding site [ion binding]; other site 1323661006853 domain II; other site 1323661006854 domain III; other site 1323661006855 nucleotide binding site [chemical binding]; other site 1323661006856 catalytic site [active] 1323661006857 domain IV; other site 1323661006858 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1323661006859 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1323661006860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661006861 Coenzyme A binding pocket [chemical binding]; other site 1323661006862 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1323661006863 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1323661006864 Predicted permeases [General function prediction only]; Region: COG0679 1323661006865 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1323661006866 MMPL family; Region: MMPL; cl14618 1323661006867 MMPL family; Region: MMPL; cl14618 1323661006868 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1323661006869 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1323661006870 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661006871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1323661006872 dimerization interface [polypeptide binding]; other site 1323661006873 putative Zn2+ binding site [ion binding]; other site 1323661006874 putative DNA binding site [nucleotide binding]; other site 1323661006875 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661006876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661006877 putative substrate translocation pore; other site 1323661006878 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1323661006879 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661006880 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1323661006881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661006882 FeS/SAM binding site; other site 1323661006883 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1323661006884 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1323661006885 GTP binding site; other site 1323661006886 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1323661006887 MoaE interaction surface [polypeptide binding]; other site 1323661006888 MoeB interaction surface [polypeptide binding]; other site 1323661006889 thiocarboxylated glycine; other site 1323661006890 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1323661006891 MoaE homodimer interface [polypeptide binding]; other site 1323661006892 MoaD interaction [polypeptide binding]; other site 1323661006893 active site residues [active] 1323661006894 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1323661006895 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1323661006896 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1323661006897 dimer interface [polypeptide binding]; other site 1323661006898 putative functional site; other site 1323661006899 putative MPT binding site; other site 1323661006900 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1323661006901 trimer interface [polypeptide binding]; other site 1323661006902 dimer interface [polypeptide binding]; other site 1323661006903 putative active site [active] 1323661006904 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1323661006905 MPT binding site; other site 1323661006906 trimer interface [polypeptide binding]; other site 1323661006907 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1323661006908 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1323661006909 ATP binding site [chemical binding]; other site 1323661006910 substrate interface [chemical binding]; other site 1323661006911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661006912 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1323661006913 Walker A/P-loop; other site 1323661006914 ATP binding site [chemical binding]; other site 1323661006915 Q-loop/lid; other site 1323661006916 ABC transporter signature motif; other site 1323661006917 Walker B; other site 1323661006918 D-loop; other site 1323661006919 H-loop/switch region; other site 1323661006920 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1323661006921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661006922 dimer interface [polypeptide binding]; other site 1323661006923 conserved gate region; other site 1323661006924 putative PBP binding loops; other site 1323661006925 ABC-ATPase subunit interface; other site 1323661006926 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1323661006927 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1323661006928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661006929 Coenzyme A binding pocket [chemical binding]; other site 1323661006930 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1323661006931 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1323661006932 active site 1323661006933 dimerization interface [polypeptide binding]; other site 1323661006934 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1323661006935 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1323661006936 intersubunit interface [polypeptide binding]; other site 1323661006937 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1323661006938 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 1323661006939 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1323661006940 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1323661006941 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1323661006942 alpha-gamma subunit interface [polypeptide binding]; other site 1323661006943 beta-gamma subunit interface [polypeptide binding]; other site 1323661006944 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1323661006945 gamma-beta subunit interface [polypeptide binding]; other site 1323661006946 alpha-beta subunit interface [polypeptide binding]; other site 1323661006947 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1323661006948 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1323661006949 subunit interactions [polypeptide binding]; other site 1323661006950 active site 1323661006951 flap region; other site 1323661006952 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1323661006953 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1323661006954 dimer interface [polypeptide binding]; other site 1323661006955 catalytic residues [active] 1323661006956 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1323661006957 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1323661006958 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1323661006959 MarR family; Region: MarR_2; cl17246 1323661006960 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661006961 Bacterial PH domain; Region: bPH_3; pfam14470 1323661006962 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1323661006963 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1323661006964 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661006965 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1323661006966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1323661006967 Surface antigen [General function prediction only]; Region: COG3942 1323661006968 CHAP domain; Region: CHAP; pfam05257 1323661006969 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1323661006970 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1323661006971 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1323661006972 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1323661006973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1323661006974 Surface antigen [General function prediction only]; Region: COG3942 1323661006975 CHAP domain; Region: CHAP; pfam05257 1323661006976 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1323661006977 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1323661006978 putative ligand binding site [chemical binding]; other site 1323661006979 putative NAD binding site [chemical binding]; other site 1323661006980 catalytic site [active] 1323661006981 hypothetical protein; Provisional; Region: PRK06753 1323661006982 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1323661006983 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1323661006984 Lysozyme subfamily 2; Region: LYZ2; smart00047 1323661006985 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1323661006986 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1323661006987 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1323661006988 catalytic loop [active] 1323661006989 iron binding site [ion binding]; other site 1323661006990 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1323661006991 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1323661006992 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1323661006993 [4Fe-4S] binding site [ion binding]; other site 1323661006994 molybdopterin cofactor binding site; other site 1323661006995 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1323661006996 molybdopterin cofactor binding site; other site 1323661006997 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1323661006998 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1323661006999 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1323661007000 active site 1323661007001 Predicted transcriptional regulator [Transcription]; Region: COG2378 1323661007002 HTH domain; Region: HTH_11; pfam08279 1323661007003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1323661007004 CAAX protease self-immunity; Region: Abi; pfam02517 1323661007005 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1323661007006 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1323661007007 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1323661007008 putative active site [active] 1323661007009 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1323661007010 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1323661007011 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1323661007012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661007013 active site 1323661007014 motif I; other site 1323661007015 motif II; other site 1323661007016 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1323661007017 Sodium Bile acid symporter family; Region: SBF; pfam01758 1323661007018 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1323661007019 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1323661007020 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1323661007021 active site turn [active] 1323661007022 phosphorylation site [posttranslational modification] 1323661007023 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1323661007024 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1323661007025 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1323661007026 putative active site [active] 1323661007027 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1323661007028 putative hydrophobic ligand binding site [chemical binding]; other site 1323661007029 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1323661007030 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1323661007031 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1323661007032 oxidoreductase; Provisional; Region: PRK07985 1323661007033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661007034 NAD(P) binding site [chemical binding]; other site 1323661007035 active site 1323661007036 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1323661007037 amidohydrolase; Region: amidohydrolases; TIGR01891 1323661007038 metal binding site [ion binding]; metal-binding site 1323661007039 dimer interface [polypeptide binding]; other site 1323661007040 imidazolonepropionase; Validated; Region: PRK09356 1323661007041 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1323661007042 active site 1323661007043 urocanate hydratase; Provisional; Region: PRK05414 1323661007044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1323661007045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1323661007046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1323661007047 dimerization interface [polypeptide binding]; other site 1323661007048 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1323661007049 putative active site [active] 1323661007050 putative metal binding site [ion binding]; other site 1323661007051 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1323661007052 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1323661007053 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1323661007054 active site 1323661007055 dimer interface [polypeptide binding]; other site 1323661007056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1323661007057 MOSC domain; Region: MOSC; pfam03473 1323661007058 3-alpha domain; Region: 3-alpha; pfam03475 1323661007059 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1323661007060 active site 1323661007061 catalytic residues [active] 1323661007062 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1323661007063 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1323661007064 Acyltransferase family; Region: Acyl_transf_3; cl19154 1323661007065 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1323661007066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661007067 Walker A/P-loop; other site 1323661007068 ATP binding site [chemical binding]; other site 1323661007069 Q-loop/lid; other site 1323661007070 ABC transporter signature motif; other site 1323661007071 Walker B; other site 1323661007072 D-loop; other site 1323661007073 H-loop/switch region; other site 1323661007074 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1323661007075 Predicted membrane protein [Function unknown]; Region: COG3152 1323661007076 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1323661007077 active site 1323661007078 DNA binding site [nucleotide binding] 1323661007079 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1323661007080 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1323661007081 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1323661007082 homotetramer interface [polypeptide binding]; other site 1323661007083 FMN binding site [chemical binding]; other site 1323661007084 homodimer contacts [polypeptide binding]; other site 1323661007085 putative active site [active] 1323661007086 putative substrate binding site [chemical binding]; other site 1323661007087 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1323661007088 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1323661007089 oligomer interface [polypeptide binding]; other site 1323661007090 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1323661007091 active site 1323661007092 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1323661007093 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1323661007094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007095 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1323661007096 putative substrate translocation pore; other site 1323661007097 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1323661007098 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1323661007099 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1323661007100 HlyD family secretion protein; Region: HlyD_3; pfam13437 1323661007101 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1323661007102 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 1323661007103 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1323661007104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007105 putative substrate translocation pore; other site 1323661007106 Predicted membrane protein [Function unknown]; Region: COG4640 1323661007107 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1323661007108 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661007109 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1323661007110 putative Zn2+ binding site [ion binding]; other site 1323661007111 putative DNA binding site [nucleotide binding]; other site 1323661007112 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1323661007113 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1323661007114 putative active site [active] 1323661007115 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1323661007116 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1323661007117 Walker A/P-loop; other site 1323661007118 ATP binding site [chemical binding]; other site 1323661007119 Q-loop/lid; other site 1323661007120 ABC transporter signature motif; other site 1323661007121 Walker B; other site 1323661007122 D-loop; other site 1323661007123 H-loop/switch region; other site 1323661007124 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1323661007125 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1323661007126 FtsX-like permease family; Region: FtsX; pfam02687 1323661007127 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661007128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661007129 active site 1323661007130 phosphorylation site [posttranslational modification] 1323661007131 intermolecular recognition site; other site 1323661007132 dimerization interface [polypeptide binding]; other site 1323661007133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661007134 DNA binding site [nucleotide binding] 1323661007135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1323661007136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1323661007137 dimerization interface [polypeptide binding]; other site 1323661007138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1323661007139 dimer interface [polypeptide binding]; other site 1323661007140 phosphorylation site [posttranslational modification] 1323661007141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661007142 ATP binding site [chemical binding]; other site 1323661007143 Mg2+ binding site [ion binding]; other site 1323661007144 G-X-G motif; other site 1323661007145 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1323661007146 LytTr DNA-binding domain; Region: LytTR; pfam04397 1323661007147 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1323661007148 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1323661007149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1323661007150 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1323661007151 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1323661007152 Walker A/P-loop; other site 1323661007153 ATP binding site [chemical binding]; other site 1323661007154 Q-loop/lid; other site 1323661007155 ABC transporter signature motif; other site 1323661007156 Walker B; other site 1323661007157 D-loop; other site 1323661007158 H-loop/switch region; other site 1323661007159 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1323661007160 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1323661007161 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 1323661007162 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1323661007163 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1323661007164 L-lactate permease; Region: Lactate_perm; cl00701 1323661007165 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1323661007166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1323661007167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661007168 Coenzyme A binding pocket [chemical binding]; other site 1323661007169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1323661007170 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1323661007171 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1323661007172 NAD(P) binding site [chemical binding]; other site 1323661007173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661007174 Coenzyme A binding pocket [chemical binding]; other site 1323661007175 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1323661007176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1323661007177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661007178 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1323661007179 Predicted membrane protein [Function unknown]; Region: COG1511 1323661007180 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 1323661007181 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1323661007182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1323661007183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1323661007184 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1323661007185 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1323661007186 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1323661007187 Cl binding site [ion binding]; other site 1323661007188 oligomer interface [polypeptide binding]; other site 1323661007189 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1323661007190 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1323661007191 active site turn [active] 1323661007192 phosphorylation site [posttranslational modification] 1323661007193 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1323661007194 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1323661007195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1323661007196 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1323661007197 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1323661007198 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1323661007199 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1323661007200 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1323661007201 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1323661007202 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661007203 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1323661007204 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1323661007205 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1323661007206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007207 putative substrate translocation pore; other site 1323661007208 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1323661007209 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1323661007210 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1323661007211 DNA binding residues [nucleotide binding] 1323661007212 dimer interface [polypeptide binding]; other site 1323661007213 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1323661007214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1323661007215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661007216 active site 1323661007217 phosphorylation site [posttranslational modification] 1323661007218 intermolecular recognition site; other site 1323661007219 dimerization interface [polypeptide binding]; other site 1323661007220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1323661007221 DNA binding residues [nucleotide binding] 1323661007222 dimerization interface [polypeptide binding]; other site 1323661007223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1323661007224 Histidine kinase; Region: HisKA_3; pfam07730 1323661007225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661007226 ATP binding site [chemical binding]; other site 1323661007227 Mg2+ binding site [ion binding]; other site 1323661007228 G-X-G motif; other site 1323661007229 GAF domain; Region: GAF_2; pfam13185 1323661007230 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1323661007231 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1323661007232 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1323661007233 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1323661007234 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 1323661007235 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1323661007236 [4Fe-4S] binding site [ion binding]; other site 1323661007237 molybdopterin cofactor binding site [chemical binding]; other site 1323661007238 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1323661007239 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1323661007240 molybdopterin cofactor binding site; other site 1323661007241 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1323661007242 active site 1323661007243 SAM binding site [chemical binding]; other site 1323661007244 homodimer interface [polypeptide binding]; other site 1323661007245 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1323661007246 [2Fe-2S] cluster binding site [ion binding]; other site 1323661007247 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1323661007248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661007249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1323661007250 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1323661007251 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1323661007252 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1323661007253 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 1323661007254 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1323661007255 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1323661007256 putative active site [active] 1323661007257 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1323661007258 active site 1323661007259 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1323661007260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661007261 Coenzyme A binding pocket [chemical binding]; other site 1323661007262 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1323661007263 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1323661007264 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1323661007265 putative hydrophobic ligand binding site [chemical binding]; other site 1323661007266 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1323661007267 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1323661007268 intersubunit interface [polypeptide binding]; other site 1323661007269 YodA lipocalin-like domain; Region: YodA; pfam09223 1323661007270 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1323661007271 Thioredoxin; Region: Thioredoxin_4; pfam13462 1323661007272 Domain of unknown function with cystatin-like fold (DUF4467); Region: DUF4467; pfam14729 1323661007273 FemAB family; Region: FemAB; pfam02388 1323661007274 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1323661007275 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1323661007276 Walker A/P-loop; other site 1323661007277 ATP binding site [chemical binding]; other site 1323661007278 Q-loop/lid; other site 1323661007279 ABC transporter signature motif; other site 1323661007280 Walker B; other site 1323661007281 D-loop; other site 1323661007282 H-loop/switch region; other site 1323661007283 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1323661007284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661007285 dimer interface [polypeptide binding]; other site 1323661007286 conserved gate region; other site 1323661007287 putative PBP binding loops; other site 1323661007288 ABC-ATPase subunit interface; other site 1323661007289 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1323661007290 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1323661007291 substrate binding pocket [chemical binding]; other site 1323661007292 membrane-bound complex binding site; other site 1323661007293 hinge residues; other site 1323661007294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1323661007295 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1323661007296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007297 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661007298 putative substrate translocation pore; other site 1323661007299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007300 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1323661007301 catalytic core [active] 1323661007302 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1323661007303 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1323661007304 B domain; Region: B; pfam02216 1323661007305 B domain; Region: B; pfam02216 1323661007306 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 1323661007307 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1323661007308 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1323661007309 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1323661007310 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1323661007311 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1323661007312 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 1323661007313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1323661007314 catalytic residue [active] 1323661007315 biotin synthase; Validated; Region: PRK06256 1323661007316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661007317 FeS/SAM binding site; other site 1323661007318 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1323661007319 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1323661007320 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1323661007321 inhibitor-cofactor binding pocket; inhibition site 1323661007322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661007323 catalytic residue [active] 1323661007324 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1323661007325 AAA domain; Region: AAA_26; pfam13500 1323661007326 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1323661007327 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1323661007328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661007329 Walker A/P-loop; other site 1323661007330 ATP binding site [chemical binding]; other site 1323661007331 Q-loop/lid; other site 1323661007332 ABC transporter signature motif; other site 1323661007333 Walker B; other site 1323661007334 D-loop; other site 1323661007335 H-loop/switch region; other site 1323661007336 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1323661007337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1323661007338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661007339 Walker A/P-loop; other site 1323661007340 ATP binding site [chemical binding]; other site 1323661007341 Q-loop/lid; other site 1323661007342 ABC transporter signature motif; other site 1323661007343 Walker B; other site 1323661007344 D-loop; other site 1323661007345 H-loop/switch region; other site 1323661007346 GtrA-like protein; Region: GtrA; pfam04138 1323661007347 glycerate kinase; Region: TIGR00045 1323661007348 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1323661007349 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1323661007350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007351 putative substrate translocation pore; other site 1323661007352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1323661007353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1323661007354 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1323661007355 putative phosphoesterase; Region: acc_ester; TIGR03729 1323661007356 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1323661007357 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1323661007358 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1323661007359 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1323661007360 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1323661007361 Beta-lactamase; Region: Beta-lactamase; pfam00144 1323661007362 DHHC palmitoyltransferase; Region: zf-DHHC; cl19890 1323661007363 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1323661007364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661007365 NAD(P) binding site [chemical binding]; other site 1323661007366 active site 1323661007367 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1323661007368 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1323661007369 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1323661007370 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661007371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007372 putative substrate translocation pore; other site 1323661007373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661007374 dimer interface [polypeptide binding]; other site 1323661007375 conserved gate region; other site 1323661007376 putative PBP binding loops; other site 1323661007377 ABC-ATPase subunit interface; other site 1323661007378 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1323661007379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661007380 dimer interface [polypeptide binding]; other site 1323661007381 conserved gate region; other site 1323661007382 putative PBP binding loops; other site 1323661007383 ABC-ATPase subunit interface; other site 1323661007384 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1323661007385 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1323661007386 Walker A/P-loop; other site 1323661007387 ATP binding site [chemical binding]; other site 1323661007388 Q-loop/lid; other site 1323661007389 ABC transporter signature motif; other site 1323661007390 Walker B; other site 1323661007391 D-loop; other site 1323661007392 H-loop/switch region; other site 1323661007393 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1323661007394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1323661007395 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1323661007396 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1323661007397 amino acid transporter; Region: 2A0306; TIGR00909 1323661007398 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1323661007399 substrate binding pocket [chemical binding]; other site 1323661007400 catalytic triad [active] 1323661007401 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1323661007402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007403 putative substrate translocation pore; other site 1323661007404 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1323661007405 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1323661007406 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1323661007407 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1323661007408 Walker A/P-loop; other site 1323661007409 ATP binding site [chemical binding]; other site 1323661007410 Q-loop/lid; other site 1323661007411 ABC transporter signature motif; other site 1323661007412 Walker B; other site 1323661007413 D-loop; other site 1323661007414 H-loop/switch region; other site 1323661007415 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1323661007416 oligomer interface [polypeptide binding]; other site 1323661007417 active site 1323661007418 metal binding site [ion binding]; metal-binding site 1323661007419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1323661007420 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1323661007421 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1323661007422 active site 1323661007423 FMN binding site [chemical binding]; other site 1323661007424 substrate binding site [chemical binding]; other site 1323661007425 3Fe-4S cluster binding site [ion binding]; other site 1323661007426 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1323661007427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1323661007429 putative substrate translocation pore; other site 1323661007430 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1323661007431 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1323661007432 Walker A/P-loop; other site 1323661007433 ATP binding site [chemical binding]; other site 1323661007434 Q-loop/lid; other site 1323661007435 ABC transporter signature motif; other site 1323661007436 Walker B; other site 1323661007437 D-loop; other site 1323661007438 H-loop/switch region; other site 1323661007439 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1323661007440 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1323661007441 Walker A/P-loop; other site 1323661007442 ATP binding site [chemical binding]; other site 1323661007443 Q-loop/lid; other site 1323661007444 ABC transporter signature motif; other site 1323661007445 Walker B; other site 1323661007446 D-loop; other site 1323661007447 H-loop/switch region; other site 1323661007448 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1323661007449 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1323661007450 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1323661007451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661007452 dimer interface [polypeptide binding]; other site 1323661007453 conserved gate region; other site 1323661007454 putative PBP binding loops; other site 1323661007455 ABC-ATPase subunit interface; other site 1323661007456 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1323661007457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1323661007458 dimer interface [polypeptide binding]; other site 1323661007459 conserved gate region; other site 1323661007460 putative PBP binding loops; other site 1323661007461 ABC-ATPase subunit interface; other site 1323661007462 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1323661007463 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1323661007464 substrate binding site [chemical binding]; other site 1323661007465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1323661007466 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1323661007467 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1323661007468 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1323661007469 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1323661007470 short chain dehydrogenase; Validated; Region: PRK08589 1323661007471 classical (c) SDRs; Region: SDR_c; cd05233 1323661007472 NAD(P) binding site [chemical binding]; other site 1323661007473 active site 1323661007474 AbgT putative transporter family; Region: ABG_transport; pfam03806 1323661007475 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1323661007476 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1323661007477 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1323661007478 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1323661007479 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1323661007480 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1323661007481 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1323661007482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661007483 NAD(P) binding site [chemical binding]; other site 1323661007484 active site 1323661007485 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1323661007486 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1323661007487 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1323661007488 Protein of unknown function, DUF576; Region: DUF576; cl04553 1323661007489 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1323661007490 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1323661007491 PLD-like domain; Region: PLDc_2; pfam13091 1323661007492 putative homodimer interface [polypeptide binding]; other site 1323661007493 putative active site [active] 1323661007494 catalytic site [active] 1323661007495 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1323661007496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661007497 ATP binding site [chemical binding]; other site 1323661007498 putative Mg++ binding site [ion binding]; other site 1323661007499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661007500 nucleotide binding region [chemical binding]; other site 1323661007501 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1323661007502 ATP-binding site [chemical binding]; other site 1323661007503 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1323661007504 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1323661007505 active site 1323661007506 8-oxo-dGMP binding site [chemical binding]; other site 1323661007507 nudix motif; other site 1323661007508 metal binding site [ion binding]; metal-binding site 1323661007509 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1323661007510 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1323661007511 active site 1323661007512 substrate binding site [chemical binding]; other site 1323661007513 metal binding site [ion binding]; metal-binding site 1323661007514 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1323661007515 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1323661007516 active site 1323661007517 tetramer interface; other site 1323661007518 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1323661007519 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1323661007520 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1323661007521 Fibronectin binding repeat; Region: Fn_bind; pfam02986 1323661007522 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1323661007523 GntP family permease; Region: GntP_permease; pfam02447 1323661007524 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1323661007525 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1323661007526 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1323661007527 N- and C-terminal domain interface [polypeptide binding]; other site 1323661007528 active site 1323661007529 catalytic site [active] 1323661007530 metal binding site [ion binding]; metal-binding site 1323661007531 carbohydrate binding site [chemical binding]; other site 1323661007532 ATP binding site [chemical binding]; other site 1323661007533 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1323661007534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1323661007535 DNA-binding site [nucleotide binding]; DNA binding site 1323661007536 FCD domain; Region: FCD; pfam07729 1323661007537 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1323661007538 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1323661007539 DNA binding residues [nucleotide binding] 1323661007540 dimer interface [polypeptide binding]; other site 1323661007541 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1323661007542 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1323661007543 synthetase active site [active] 1323661007544 NTP binding site [chemical binding]; other site 1323661007545 metal binding site [ion binding]; metal-binding site 1323661007546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1323661007547 Predicted membrane protein [Function unknown]; Region: COG1289 1323661007548 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1323661007549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1323661007550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1323661007551 putative substrate translocation pore; other site 1323661007552 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1323661007553 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1323661007554 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1323661007555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661007556 Walker A/P-loop; other site 1323661007557 ATP binding site [chemical binding]; other site 1323661007558 Q-loop/lid; other site 1323661007559 ABC transporter signature motif; other site 1323661007560 Walker B; other site 1323661007561 D-loop; other site 1323661007562 H-loop/switch region; other site 1323661007563 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1323661007564 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1323661007565 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1323661007566 Predicted esterase [General function prediction only]; Region: COG0400 1323661007567 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 1323661007568 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1323661007569 Zn binding site [ion binding]; other site 1323661007570 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1323661007571 Zn binding site [ion binding]; other site 1323661007572 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1323661007573 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1323661007574 putative Zn2+ binding site [ion binding]; other site 1323661007575 putative DNA binding site [nucleotide binding]; other site 1323661007576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661007577 Coenzyme A binding pocket [chemical binding]; other site 1323661007578 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1323661007579 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1323661007580 putative metal binding site [ion binding]; other site 1323661007581 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1323661007582 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1323661007583 dimer interface [polypeptide binding]; other site 1323661007584 FMN binding site [chemical binding]; other site 1323661007585 D-lactate dehydrogenase; Provisional; Region: PRK12480 1323661007586 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1323661007587 homodimer interface [polypeptide binding]; other site 1323661007588 ligand binding site [chemical binding]; other site 1323661007589 NAD binding site [chemical binding]; other site 1323661007590 catalytic site [active] 1323661007591 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1323661007592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1323661007593 active site 1323661007594 motif I; other site 1323661007595 motif II; other site 1323661007596 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 1323661007597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1323661007598 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1323661007599 Walker A/P-loop; other site 1323661007600 ATP binding site [chemical binding]; other site 1323661007601 Q-loop/lid; other site 1323661007602 ABC transporter signature motif; other site 1323661007603 Walker B; other site 1323661007604 D-loop; other site 1323661007605 H-loop/switch region; other site 1323661007606 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1323661007607 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1323661007608 active site 1323661007609 catalytic site [active] 1323661007610 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1323661007611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661007612 Coenzyme A binding pocket [chemical binding]; other site 1323661007613 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1323661007614 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1323661007615 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1323661007616 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1323661007617 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1323661007618 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1323661007619 EamA-like transporter family; Region: EamA; pfam00892 1323661007620 EamA-like transporter family; Region: EamA; pfam00892 1323661007621 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1323661007622 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1323661007623 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1323661007624 catalytic residues [active] 1323661007625 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1323661007626 active site 1323661007627 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1323661007628 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1323661007629 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1323661007630 active site turn [active] 1323661007631 phosphorylation site [posttranslational modification] 1323661007632 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1323661007633 HPr interaction site; other site 1323661007634 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1323661007635 active site 1323661007636 phosphorylation site [posttranslational modification] 1323661007637 pyruvate oxidase; Provisional; Region: PRK08611 1323661007638 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1323661007639 PYR/PP interface [polypeptide binding]; other site 1323661007640 tetramer interface [polypeptide binding]; other site 1323661007641 dimer interface [polypeptide binding]; other site 1323661007642 TPP binding site [chemical binding]; other site 1323661007643 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1323661007644 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1323661007645 TPP-binding site [chemical binding]; other site 1323661007646 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1323661007647 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1323661007648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1323661007649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1323661007650 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1323661007651 putative dimerization interface [polypeptide binding]; other site 1323661007652 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1323661007653 Surface antigen [General function prediction only]; Region: COG3942 1323661007654 CHAP domain; Region: CHAP; pfam05257 1323661007655 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1323661007656 homodimer interface [polypeptide binding]; other site 1323661007657 catalytic residues [active] 1323661007658 NAD binding site [chemical binding]; other site 1323661007659 substrate binding pocket [chemical binding]; other site 1323661007660 flexible flap; other site 1323661007661 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1323661007662 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1323661007663 dimer interface [polypeptide binding]; other site 1323661007664 active site 1323661007665 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1323661007666 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1323661007667 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1323661007668 DNA binding site [nucleotide binding] 1323661007669 active site 1323661007670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661007671 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1323661007672 Walker A motif; other site 1323661007673 ATP binding site [chemical binding]; other site 1323661007674 Walker B motif; other site 1323661007675 arginine finger; other site 1323661007676 UvrB/uvrC motif; Region: UVR; pfam02151 1323661007677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1323661007678 Walker A motif; other site 1323661007679 ATP binding site [chemical binding]; other site 1323661007680 Walker B motif; other site 1323661007681 arginine finger; other site 1323661007682 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1323661007683 Virus attachment protein p12 family; Region: P12; pfam12669 1323661007684 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1323661007685 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1323661007686 G1 box; other site 1323661007687 GTP/Mg2+ binding site [chemical binding]; other site 1323661007688 Switch I region; other site 1323661007689 G2 box; other site 1323661007690 G3 box; other site 1323661007691 Switch II region; other site 1323661007692 G4 box; other site 1323661007693 G5 box; other site 1323661007694 Nucleoside recognition; Region: Gate; pfam07670 1323661007695 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1323661007696 Nucleoside recognition; Region: Gate; pfam07670 1323661007697 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1323661007698 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1323661007699 MMPL family; Region: MMPL; pfam03176 1323661007700 MMPL family; Region: MMPL; cl14618 1323661007701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1323661007702 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 1323661007703 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1323661007704 Glutamate binding site [chemical binding]; other site 1323661007705 homodimer interface [polypeptide binding]; other site 1323661007706 NAD binding site [chemical binding]; other site 1323661007707 catalytic residues [active] 1323661007708 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1323661007709 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1323661007710 active site 1323661007711 substrate binding site [chemical binding]; other site 1323661007712 trimer interface [polypeptide binding]; other site 1323661007713 CoA binding site [chemical binding]; other site 1323661007714 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1323661007715 metal-binding site [ion binding] 1323661007716 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1323661007717 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1323661007718 metal-binding site [ion binding] 1323661007719 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1323661007720 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1323661007721 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1323661007722 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1323661007723 metal-binding site [ion binding] 1323661007724 D-lactate dehydrogenase; Validated; Region: PRK08605 1323661007725 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1323661007726 homodimer interface [polypeptide binding]; other site 1323661007727 ligand binding site [chemical binding]; other site 1323661007728 NAD binding site [chemical binding]; other site 1323661007729 catalytic site [active] 1323661007730 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1323661007731 homodimer interface [polypeptide binding]; other site 1323661007732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661007733 catalytic residue [active] 1323661007734 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1323661007735 phytoene desaturase; Region: crtI_fam; TIGR02734 1323661007736 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1323661007737 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1323661007738 active site lid residues [active] 1323661007739 substrate binding pocket [chemical binding]; other site 1323661007740 catalytic residues [active] 1323661007741 substrate-Mg2+ binding site; other site 1323661007742 aspartate-rich region 1; other site 1323661007743 aspartate-rich region 2; other site 1323661007744 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1323661007745 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1323661007746 active site 1323661007747 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1323661007748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661007749 Surface antigen [General function prediction only]; Region: COG3942 1323661007750 CHAP domain; Region: CHAP; pfam05257 1323661007751 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1323661007752 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1323661007753 catalytic triad [active] 1323661007754 catalytic triad [active] 1323661007755 oxyanion hole [active] 1323661007756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661007757 Coenzyme A binding pocket [chemical binding]; other site 1323661007758 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1323661007759 catalytic residue [active] 1323661007760 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1323661007761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1323661007762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1323661007763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1323661007764 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1323661007765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1323661007766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661007767 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1323661007768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661007769 NAD(P) binding site [chemical binding]; other site 1323661007770 active site 1323661007771 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 1323661007772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1323661007773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1323661007774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1323661007775 short chain dehydrogenase; Region: adh_short; pfam00106 1323661007776 NAD(P) binding site [chemical binding]; other site 1323661007777 active site 1323661007778 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1323661007779 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1323661007780 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1323661007781 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1323661007782 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1323661007783 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1323661007784 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1323661007785 Nucleoside recognition; Region: Gate; pfam07670 1323661007786 Nucleoside recognition; Region: Gate; pfam07670 1323661007787 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1323661007788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1323661007789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 1323661007790 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1323661007791 Phosphotransferase enzyme family; Region: APH; pfam01636 1323661007792 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1323661007793 active site 1323661007794 substrate binding site [chemical binding]; other site 1323661007795 ATP binding site [chemical binding]; other site 1323661007796 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1323661007797 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1323661007798 quinone interaction residues [chemical binding]; other site 1323661007799 active site 1323661007800 catalytic residues [active] 1323661007801 FMN binding site [chemical binding]; other site 1323661007802 substrate binding site [chemical binding]; other site 1323661007803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1323661007804 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1323661007805 dimer interface [polypeptide binding]; other site 1323661007806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1323661007807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1323661007808 Predicted acyl esterases [General function prediction only]; Region: COG2936 1323661007809 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1323661007810 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1323661007811 tetramerization interface [polypeptide binding]; other site 1323661007812 active site 1323661007813 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1323661007814 active site 1323661007815 ATP-binding site [chemical binding]; other site 1323661007816 pantoate-binding site; other site 1323661007817 HXXH motif; other site 1323661007818 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1323661007819 oligomerization interface [polypeptide binding]; other site 1323661007820 active site 1323661007821 metal binding site [ion binding]; metal-binding site 1323661007822 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1323661007823 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1323661007824 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1323661007825 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1323661007826 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1323661007827 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1323661007828 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1323661007829 NAD binding site [chemical binding]; other site 1323661007830 dimer interface [polypeptide binding]; other site 1323661007831 substrate binding site [chemical binding]; other site 1323661007832 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1323661007833 amino acid transporter; Region: 2A0306; TIGR00909 1323661007834 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1323661007835 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1323661007836 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1323661007837 inhibitor-cofactor binding pocket; inhibition site 1323661007838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661007839 catalytic residue [active] 1323661007840 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1323661007841 catalytic residue [active] 1323661007842 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1323661007843 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1323661007844 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1323661007845 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1323661007846 acyl-activating enzyme (AAE) consensus motif; other site 1323661007847 AMP binding site [chemical binding]; other site 1323661007848 active site 1323661007849 CoA binding site [chemical binding]; other site 1323661007850 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1323661007851 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1323661007852 choline dehydrogenase; Validated; Region: PRK02106 1323661007853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 1323661007854 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1323661007855 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1323661007856 tetramerization interface [polypeptide binding]; other site 1323661007857 NAD(P) binding site [chemical binding]; other site 1323661007858 catalytic residues [active] 1323661007859 Predicted transcriptional regulators [Transcription]; Region: COG1510 1323661007860 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1323661007861 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1323661007862 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1323661007863 FeS/SAM binding site; other site 1323661007864 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1323661007865 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1323661007866 effector binding site; other site 1323661007867 active site 1323661007868 Zn binding site [ion binding]; other site 1323661007869 glycine loop; other site 1323661007870 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1323661007871 Citrate transporter; Region: CitMHS; pfam03600 1323661007872 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1323661007873 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1323661007874 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 1323661007875 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1323661007876 Flavodoxin; Region: Flavodoxin_1; pfam00258 1323661007877 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1323661007878 FAD binding pocket [chemical binding]; other site 1323661007879 FAD binding motif [chemical binding]; other site 1323661007880 catalytic residues [active] 1323661007881 NAD binding pocket [chemical binding]; other site 1323661007882 phosphate binding motif [ion binding]; other site 1323661007883 beta-alpha-beta structure motif; other site 1323661007884 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1323661007885 catalytic residues [active] 1323661007886 dimer interface [polypeptide binding]; other site 1323661007887 FtsX-like permease family; Region: FtsX; pfam02687 1323661007888 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1323661007889 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1323661007890 Walker A/P-loop; other site 1323661007891 ATP binding site [chemical binding]; other site 1323661007892 Q-loop/lid; other site 1323661007893 ABC transporter signature motif; other site 1323661007894 Walker B; other site 1323661007895 D-loop; other site 1323661007896 H-loop/switch region; other site 1323661007897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1323661007898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1323661007899 ATP binding site [chemical binding]; other site 1323661007900 Mg2+ binding site [ion binding]; other site 1323661007901 G-X-G motif; other site 1323661007902 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1323661007903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1323661007904 active site 1323661007905 phosphorylation site [posttranslational modification] 1323661007906 intermolecular recognition site; other site 1323661007907 dimerization interface [polypeptide binding]; other site 1323661007908 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1323661007909 DNA binding site [nucleotide binding] 1323661007910 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1323661007911 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1323661007912 dimer interface [polypeptide binding]; other site 1323661007913 active site 1323661007914 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1323661007915 MarR family; Region: MarR_2; pfam12802 1323661007916 Predicted esterase [General function prediction only]; Region: COG0627 1323661007917 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 1323661007918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1323661007919 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1323661007920 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1323661007921 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1323661007922 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1323661007923 ligand binding site [chemical binding]; other site 1323661007924 flexible hinge region; other site 1323661007925 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1323661007926 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1323661007927 putative substrate binding site [chemical binding]; other site 1323661007928 nucleotide binding site [chemical binding]; other site 1323661007929 nucleotide binding site [chemical binding]; other site 1323661007930 homodimer interface [polypeptide binding]; other site 1323661007931 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1323661007932 ornithine carbamoyltransferase; Validated; Region: PRK02102 1323661007933 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1323661007934 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1323661007935 arginine deiminase; Provisional; Region: PRK01388 1323661007936 Arginine repressor [Transcription]; Region: ArgR; COG1438 1323661007937 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1323661007938 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1323661007939 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1323661007940 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1323661007941 active site 1323661007942 Zn binding site [ion binding]; other site 1323661007943 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1323661007944 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1323661007945 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1323661007946 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1323661007947 HTH domain; Region: HTH_11; pfam08279 1323661007948 PRD domain; Region: PRD; pfam00874 1323661007949 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1323661007950 active site 1323661007951 P-loop; other site 1323661007952 phosphorylation site [posttranslational modification] 1323661007953 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1323661007954 active site 1323661007955 phosphorylation site [posttranslational modification] 1323661007956 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1323661007957 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1323661007958 active site 1323661007959 P-loop; other site 1323661007960 phosphorylation site [posttranslational modification] 1323661007961 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1323661007962 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1323661007963 active site 1323661007964 phosphorylation site [posttranslational modification] 1323661007965 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1323661007966 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 1323661007967 Predicted membrane protein [Function unknown]; Region: COG1511 1323661007968 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 1323661007969 Retro-transposon transporting motif; Region: Nup_retrotrp_bd; pfam10599 1323661007970 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1323661007971 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1323661007972 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1323661007973 CHAP domain; Region: CHAP; pfam05257 1323661007974 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1323661007975 catalytic triad [active] 1323661007976 conserved cis-peptide bond; other site 1323661007977 Protein of unknown function (DUF812); Region: DUF812; pfam05667 1323661007978 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1323661007979 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1323661007980 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1323661007981 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1323661007982 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1323661007983 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1323661007984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1323661007985 ATP binding site [chemical binding]; other site 1323661007986 putative Mg++ binding site [ion binding]; other site 1323661007987 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1323661007988 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1323661007989 nucleotide binding region [chemical binding]; other site 1323661007990 ATP-binding site [chemical binding]; other site 1323661007991 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 1323661007992 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1323661007993 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1323661007994 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1323661007995 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1323661007996 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1323661007997 SecY translocase; Region: SecY; pfam00344 1323661007998 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1323661007999 legume lectins; Region: lectin_L-type; cd01951 1323661008000 homotetramer interaction site [polypeptide binding]; other site 1323661008001 carbohydrate binding site [chemical binding]; other site 1323661008002 metal binding site [ion binding]; metal-binding site 1323661008003 Putative Ig domain; Region: He_PIG; pfam05345 1323661008004 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1323661008005 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1323661008006 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1323661008007 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1323661008008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1323661008009 Coenzyme A binding pocket [chemical binding]; other site 1323661008010 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1323661008011 PHP domain; Region: PHP; pfam02811 1323661008012 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1323661008013 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1323661008014 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1323661008015 Chain length determinant protein; Region: Wzz; cl15801 1323661008016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1323661008017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1323661008018 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1323661008019 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1323661008020 DXD motif; other site 1323661008021 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 1323661008022 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 1323661008023 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1323661008024 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1323661008025 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1323661008026 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1323661008027 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1323661008028 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1323661008029 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1323661008030 metal binding site [ion binding]; metal-binding site 1323661008031 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1323661008032 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1323661008033 substrate binding site [chemical binding]; other site 1323661008034 glutamase interaction surface [polypeptide binding]; other site 1323661008035 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1323661008036 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1323661008037 catalytic residues [active] 1323661008038 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1323661008039 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1323661008040 putative active site [active] 1323661008041 oxyanion strand; other site 1323661008042 catalytic triad [active] 1323661008043 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1323661008044 putative active site pocket [active] 1323661008045 4-fold oligomerization interface [polypeptide binding]; other site 1323661008046 metal binding residues [ion binding]; metal-binding site 1323661008047 3-fold/trimer interface [polypeptide binding]; other site 1323661008048 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1323661008049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1323661008050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1323661008051 homodimer interface [polypeptide binding]; other site 1323661008052 catalytic residue [active] 1323661008053 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1323661008054 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1323661008055 NAD binding site [chemical binding]; other site 1323661008056 dimerization interface [polypeptide binding]; other site 1323661008057 product binding site; other site 1323661008058 substrate binding site [chemical binding]; other site 1323661008059 zinc binding site [ion binding]; other site 1323661008060 catalytic residues [active] 1323661008061 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 1323661008062 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1323661008063 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1323661008064 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1323661008065 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1323661008066 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1323661008067 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1323661008068 Strictosidine synthase; Region: Str_synth; pfam03088 1323661008069 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1323661008070 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1323661008071 active site residue [active] 1323661008072 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1323661008073 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1323661008074 putative substrate binding pocket [chemical binding]; other site 1323661008075 AC domain interface; other site 1323661008076 catalytic triad [active] 1323661008077 AB domain interface; other site 1323661008078 interchain disulfide; other site 1323661008079 DinB superfamily; Region: DinB_2; pfam12867 1323661008080 Collagen binding domain; Region: Collagen_bind; pfam05737 1323661008081 Cna protein B-type domain; Region: Cna_B; pfam05738 1323661008082 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1323661008083 domain interaction interfaces [polypeptide binding]; other site 1323661008084 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1323661008085 domain interaction interfaces [polypeptide binding]; other site 1323661008086 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1323661008087 domain interaction interfaces [polypeptide binding]; other site 1323661008088 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1323661008089 domain interaction interfaces [polypeptide binding]; other site 1323661008090 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1323661008091 domain interaction interfaces [polypeptide binding]; other site 1323661008092 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 1323661008093 anion transporter; Region: dass; TIGR00785 1323661008094 transmembrane helices; other site 1323661008095 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1323661008096 hypothetical protein; Provisional; Region: PRK07758 1323661008097 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1323661008098 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1323661008099 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1323661008100 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1323661008101 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1323661008102 Walker A/P-loop; other site 1323661008103 ATP binding site [chemical binding]; other site 1323661008104 Q-loop/lid; other site 1323661008105 ABC transporter signature motif; other site 1323661008106 Walker B; other site 1323661008107 D-loop; other site 1323661008108 H-loop/switch region; other site 1323661008109 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1323661008110 FtsX-like permease family; Region: FtsX; pfam02687 1323661008111 FtsX-like permease family; Region: FtsX; pfam02687 1323661008112 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1323661008113 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1323661008114 active site 1323661008115 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1323661008116 DNA-binding site [nucleotide binding]; DNA binding site 1323661008117 RNA-binding motif; other site 1323661008118 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1323661008119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1323661008120 non-specific DNA binding site [nucleotide binding]; other site 1323661008121 salt bridge; other site 1323661008122 sequence-specific DNA binding site [nucleotide binding]; other site 1323661008123 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1323661008124 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1323661008125 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1323661008126 ParB-like nuclease domain; Region: ParBc; pfam02195 1323661008127 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1323661008128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1323661008129 S-adenosylmethionine binding site [chemical binding]; other site 1323661008130 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1323661008131 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1323661008132 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1323661008133 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1323661008134 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1323661008135 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1323661008136 G1 box; other site 1323661008137 GTP/Mg2+ binding site [chemical binding]; other site 1323661008138 Switch I region; other site 1323661008139 G2 box; other site 1323661008140 Switch II region; other site 1323661008141 G3 box; other site 1323661008142 G4 box; other site 1323661008143 G5 box; other site 1323661008144 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1323661008145 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1323661008146 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399