-- dump date 20140620_073320 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1155084000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1155084000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1155084000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084000004 Walker A motif; other site 1155084000005 ATP binding site [chemical binding]; other site 1155084000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1155084000007 Walker B motif; other site 1155084000008 arginine finger; other site 1155084000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1155084000010 DnaA box-binding interface [nucleotide binding]; other site 1155084000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1155084000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1155084000013 putative DNA binding surface [nucleotide binding]; other site 1155084000014 dimer interface [polypeptide binding]; other site 1155084000015 beta-clamp/clamp loader binding surface; other site 1155084000016 beta-clamp/translesion DNA polymerase binding surface; other site 1155084000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1155084000018 recF protein; Region: recf; TIGR00611 1155084000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1155084000020 Walker A/P-loop; other site 1155084000021 ATP binding site [chemical binding]; other site 1155084000022 Q-loop/lid; other site 1155084000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084000024 ABC transporter signature motif; other site 1155084000025 Walker B; other site 1155084000026 D-loop; other site 1155084000027 H-loop/switch region; other site 1155084000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1155084000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084000030 Mg2+ binding site [ion binding]; other site 1155084000031 G-X-G motif; other site 1155084000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1155084000033 anchoring element; other site 1155084000034 dimer interface [polypeptide binding]; other site 1155084000035 ATP binding site [chemical binding]; other site 1155084000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1155084000037 active site 1155084000038 putative metal-binding site [ion binding]; other site 1155084000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1155084000040 DNA gyrase subunit A; Validated; Region: PRK05560 1155084000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1155084000042 CAP-like domain; other site 1155084000043 active site 1155084000044 primary dimer interface [polypeptide binding]; other site 1155084000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155084000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155084000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155084000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155084000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155084000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155084000051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1155084000052 putative substrate binding site [chemical binding]; other site 1155084000053 putative ATP binding site [chemical binding]; other site 1155084000054 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1155084000055 active sites [active] 1155084000056 tetramer interface [polypeptide binding]; other site 1155084000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 1155084000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1155084000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1155084000060 dimer interface [polypeptide binding]; other site 1155084000061 active site 1155084000062 motif 1; other site 1155084000063 motif 2; other site 1155084000064 motif 3; other site 1155084000065 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1155084000066 Predicted membrane protein [Function unknown]; Region: COG4392 1155084000067 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1155084000068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1155084000069 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1155084000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1155084000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1155084000072 DHH family; Region: DHH; pfam01368 1155084000073 DHHA1 domain; Region: DHHA1; pfam02272 1155084000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1155084000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1155084000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1155084000077 replicative DNA helicase; Region: DnaB; TIGR00665 1155084000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1155084000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1155084000080 Walker A motif; other site 1155084000081 ATP binding site [chemical binding]; other site 1155084000082 Walker B motif; other site 1155084000083 DNA binding loops [nucleotide binding] 1155084000084 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1155084000085 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1155084000086 GDP-binding site [chemical binding]; other site 1155084000087 ACT binding site; other site 1155084000088 IMP binding site; other site 1155084000089 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084000090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155084000091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084000092 active site 1155084000093 phosphorylation site [posttranslational modification] 1155084000094 intermolecular recognition site; other site 1155084000095 dimerization interface [polypeptide binding]; other site 1155084000096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155084000097 DNA binding site [nucleotide binding] 1155084000098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1155084000099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155084000100 dimerization interface [polypeptide binding]; other site 1155084000101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1155084000102 putative active site [active] 1155084000103 heme pocket [chemical binding]; other site 1155084000104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155084000105 dimer interface [polypeptide binding]; other site 1155084000106 phosphorylation site [posttranslational modification] 1155084000107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084000108 ATP binding site [chemical binding]; other site 1155084000109 Mg2+ binding site [ion binding]; other site 1155084000110 G-X-G motif; other site 1155084000111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1155084000112 YycH protein; Region: YycH; pfam07435 1155084000113 YycH protein; Region: YycI; cl02015 1155084000114 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1155084000115 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1155084000116 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1155084000117 putative active site [active] 1155084000118 putative metal binding site [ion binding]; other site 1155084000119 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155084000120 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1155084000121 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1155084000122 AAA domain; Region: AAA_13; pfam13166 1155084000123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1155084000124 Integrase core domain; Region: rve; pfam00665 1155084000125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084000126 Walker A motif; other site 1155084000127 ATP binding site [chemical binding]; other site 1155084000128 Walker B motif; other site 1155084000129 proteasome-activating nucleotidase; Provisional; Region: PRK03992 1155084000130 Integrase core domain; Region: rve; pfam00665 1155084000131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155084000132 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155084000133 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1155084000134 active site 1155084000135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000136 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084000137 putative substrate translocation pore; other site 1155084000138 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1155084000139 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1155084000140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155084000141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155084000142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084000143 Coenzyme A binding pocket [chemical binding]; other site 1155084000144 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1155084000145 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1155084000146 FMN binding site [chemical binding]; other site 1155084000147 active site 1155084000148 catalytic residues [active] 1155084000149 substrate binding site [chemical binding]; other site 1155084000150 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1155084000151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000152 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155084000153 putative substrate translocation pore; other site 1155084000154 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1155084000155 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1155084000156 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155084000157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155084000158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155084000159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155084000160 dimerization interface [polypeptide binding]; other site 1155084000161 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1155084000162 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1155084000163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155084000164 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1155084000165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084000166 S-adenosylmethionine binding site [chemical binding]; other site 1155084000167 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1155084000168 active site 1155084000169 catalytic site [active] 1155084000170 putative metal binding site [ion binding]; other site 1155084000171 Protein of unknown function, DUF576; Region: DUF576; cl04553 1155084000172 Protein of unknown function, DUF576; Region: DUF576; cl04553 1155084000173 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1155084000174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155084000175 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1155084000176 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155084000177 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1155084000178 metal binding site [ion binding]; metal-binding site 1155084000179 dimer interface [polypeptide binding]; other site 1155084000180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084000182 putative substrate translocation pore; other site 1155084000183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000184 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1155084000185 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1155084000186 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1155084000187 PhoU domain; Region: PhoU; pfam01895 1155084000188 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1155084000189 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1155084000190 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1155084000191 L-lactate permease; Region: Lactate_perm; cl00701 1155084000192 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084000193 B domain; Region: B; pfam02216 1155084000194 B domain; Region: B; pfam02216 1155084000195 B domain; Region: B; pfam02216 1155084000196 B domain; Region: B; pfam02216 1155084000197 B domain; Region: B; pfam02216 1155084000198 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155084000199 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1155084000200 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155084000201 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1155084000202 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155084000203 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155084000204 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084000205 ABC-ATPase subunit interface; other site 1155084000206 dimer interface [polypeptide binding]; other site 1155084000207 putative PBP binding regions; other site 1155084000208 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155084000209 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084000210 ABC-ATPase subunit interface; other site 1155084000211 dimer interface [polypeptide binding]; other site 1155084000212 putative PBP binding regions; other site 1155084000213 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1155084000214 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1155084000215 siderophore binding site; other site 1155084000216 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1155084000217 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1155084000218 dimer interface [polypeptide binding]; other site 1155084000219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084000220 catalytic residue [active] 1155084000221 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1155084000222 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1155084000223 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1155084000224 IucA / IucC family; Region: IucA_IucC; pfam04183 1155084000225 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1155084000226 drug efflux system protein MdtG; Provisional; Region: PRK09874 1155084000227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000228 putative substrate translocation pore; other site 1155084000229 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1155084000230 IucA / IucC family; Region: IucA_IucC; pfam04183 1155084000231 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1155084000232 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1155084000233 IucA / IucC family; Region: IucA_IucC; pfam04183 1155084000234 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1155084000235 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1155084000236 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1155084000237 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1155084000238 dimer interface [polypeptide binding]; other site 1155084000239 active site 1155084000240 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155084000241 catalytic residues [active] 1155084000242 substrate binding site [chemical binding]; other site 1155084000243 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1155084000244 ParB-like nuclease domain; Region: ParBc; pfam02195 1155084000245 acetoin reductase; Validated; Region: PRK08643 1155084000246 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1155084000247 NAD binding site [chemical binding]; other site 1155084000248 homotetramer interface [polypeptide binding]; other site 1155084000249 homodimer interface [polypeptide binding]; other site 1155084000250 active site 1155084000251 substrate binding site [chemical binding]; other site 1155084000252 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1155084000253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155084000254 NAD(P) binding site [chemical binding]; other site 1155084000255 active site 1155084000256 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1155084000257 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1155084000258 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155084000259 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1155084000260 putative ADP-binding pocket [chemical binding]; other site 1155084000261 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155084000262 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1155084000263 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1155084000264 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1155084000265 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1155084000266 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155084000267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155084000268 DNA-binding site [nucleotide binding]; DNA binding site 1155084000269 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1155084000270 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1155084000271 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084000272 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1155084000273 intersubunit interface [polypeptide binding]; other site 1155084000274 active site 1155084000275 catalytic residue [active] 1155084000276 phosphopentomutase; Provisional; Region: PRK05362 1155084000277 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1155084000278 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1155084000279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084000280 dimer interface [polypeptide binding]; other site 1155084000281 conserved gate region; other site 1155084000282 putative PBP binding loops; other site 1155084000283 ABC-ATPase subunit interface; other site 1155084000284 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1155084000285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084000286 dimer interface [polypeptide binding]; other site 1155084000287 conserved gate region; other site 1155084000288 ABC-ATPase subunit interface; other site 1155084000289 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1155084000290 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1155084000291 Walker A/P-loop; other site 1155084000292 ATP binding site [chemical binding]; other site 1155084000293 Q-loop/lid; other site 1155084000294 ABC transporter signature motif; other site 1155084000295 Walker B; other site 1155084000296 D-loop; other site 1155084000297 H-loop/switch region; other site 1155084000298 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1155084000299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1155084000300 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1155084000301 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1155084000302 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1155084000303 active site 1155084000304 metal binding site [ion binding]; metal-binding site 1155084000305 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155084000306 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155084000307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084000308 non-specific DNA binding site [nucleotide binding]; other site 1155084000309 salt bridge; other site 1155084000310 sequence-specific DNA binding site [nucleotide binding]; other site 1155084000311 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1155084000312 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1155084000313 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1155084000314 putative catalytic cysteine [active] 1155084000315 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1155084000316 putative active site [active] 1155084000317 metal binding site [ion binding]; metal-binding site 1155084000318 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1155084000319 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1155084000320 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1155084000321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155084000322 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1155084000323 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1155084000324 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1155084000325 NAD(P) binding site [chemical binding]; other site 1155084000326 homodimer interface [polypeptide binding]; other site 1155084000327 substrate binding site [chemical binding]; other site 1155084000328 active site 1155084000329 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1155084000330 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1155084000331 NAD(P) binding site [chemical binding]; other site 1155084000332 homodimer interface [polypeptide binding]; other site 1155084000333 substrate binding site [chemical binding]; other site 1155084000334 active site 1155084000335 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1155084000336 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1155084000337 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1155084000338 putative NAD(P) binding site [chemical binding]; other site 1155084000339 active site 1155084000340 putative substrate binding site [chemical binding]; other site 1155084000341 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1155084000342 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1155084000343 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1155084000344 active site 1155084000345 homodimer interface [polypeptide binding]; other site 1155084000346 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1155084000347 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1155084000348 trimer interface [polypeptide binding]; other site 1155084000349 active site 1155084000350 substrate binding site [chemical binding]; other site 1155084000351 CoA binding site [chemical binding]; other site 1155084000352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155084000353 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155084000354 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1155084000355 O-Antigen ligase; Region: Wzy_C; pfam04932 1155084000356 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155084000357 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1155084000358 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1155084000359 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1155084000360 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1155084000361 putative NAD(P) binding site [chemical binding]; other site 1155084000362 active site 1155084000363 putative substrate binding site [chemical binding]; other site 1155084000364 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1155084000365 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1155084000366 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1155084000367 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1155084000368 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1155084000369 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1155084000370 active site 1155084000371 homodimer interface [polypeptide binding]; other site 1155084000372 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1155084000373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1155084000374 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1155084000375 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1155084000376 NAD(P) binding site [chemical binding]; other site 1155084000377 catalytic residues [active] 1155084000378 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1155084000379 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155084000380 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1155084000381 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1155084000382 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1155084000383 Walker A/P-loop; other site 1155084000384 ATP binding site [chemical binding]; other site 1155084000385 Q-loop/lid; other site 1155084000386 ABC transporter signature motif; other site 1155084000387 Walker B; other site 1155084000388 D-loop; other site 1155084000389 H-loop/switch region; other site 1155084000390 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1155084000391 NMT1-like family; Region: NMT1_2; pfam13379 1155084000392 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1155084000393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1155084000394 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1155084000395 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1155084000396 active site 1155084000397 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1155084000398 formate dehydrogenase; Provisional; Region: PRK07574 1155084000399 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1155084000400 dimerization interface [polypeptide binding]; other site 1155084000401 ligand binding site [chemical binding]; other site 1155084000402 NAD binding site [chemical binding]; other site 1155084000403 catalytic site [active] 1155084000404 putative transporter; Provisional; Region: PRK10054 1155084000405 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1155084000406 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1155084000407 acyl-activating enzyme (AAE) consensus motif; other site 1155084000408 AMP binding site [chemical binding]; other site 1155084000409 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155084000410 Condensation domain; Region: Condensation; pfam00668 1155084000411 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1155084000412 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1155084000413 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1155084000414 acyl-activating enzyme (AAE) consensus motif; other site 1155084000415 AMP binding site [chemical binding]; other site 1155084000416 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1155084000417 thioester reductase domain; Region: Thioester-redct; TIGR01746 1155084000418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155084000419 NAD(P) binding site [chemical binding]; other site 1155084000420 active site 1155084000421 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1155084000422 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1155084000423 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1155084000424 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1155084000425 nucleotide binding site [chemical binding]; other site 1155084000426 N-acetyl-L-glutamate binding site [chemical binding]; other site 1155084000427 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1155084000428 heterotetramer interface [polypeptide binding]; other site 1155084000429 active site pocket [active] 1155084000430 cleavage site 1155084000431 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1155084000432 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1155084000433 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1155084000434 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155084000435 inhibitor-cofactor binding pocket; inhibition site 1155084000436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084000437 catalytic residue [active] 1155084000438 Amidohydrolase; Region: Amidohydro_2; pfam04909 1155084000439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155084000440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155084000441 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1155084000442 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1155084000443 Isochorismatase family; Region: Isochorismatase; pfam00857 1155084000444 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155084000445 catalytic triad [active] 1155084000446 conserved cis-peptide bond; other site 1155084000447 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1155084000448 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1155084000449 dimer interface [polypeptide binding]; other site 1155084000450 PYR/PP interface [polypeptide binding]; other site 1155084000451 TPP binding site [chemical binding]; other site 1155084000452 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155084000453 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1155084000454 TPP-binding site [chemical binding]; other site 1155084000455 dimer interface [polypeptide binding]; other site 1155084000456 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1155084000457 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155084000458 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155084000459 active site turn [active] 1155084000460 phosphorylation site [posttranslational modification] 1155084000461 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1155084000462 HPr interaction site; other site 1155084000463 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155084000464 active site 1155084000465 phosphorylation site [posttranslational modification] 1155084000466 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1155084000467 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1155084000468 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1155084000469 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1155084000470 putative active site [active] 1155084000471 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1155084000472 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155084000473 active site turn [active] 1155084000474 phosphorylation site [posttranslational modification] 1155084000475 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155084000476 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155084000477 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155084000478 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155084000479 putative active site [active] 1155084000480 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1155084000481 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1155084000482 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155084000483 ATP binding site [chemical binding]; other site 1155084000484 putative Mg++ binding site [ion binding]; other site 1155084000485 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1155084000486 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084000487 Walker A/P-loop; other site 1155084000488 ATP binding site [chemical binding]; other site 1155084000489 Q-loop/lid; other site 1155084000490 ABC transporter signature motif; other site 1155084000491 Walker B; other site 1155084000492 D-loop; other site 1155084000493 H-loop/switch region; other site 1155084000494 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1155084000495 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084000496 Walker A/P-loop; other site 1155084000497 ATP binding site [chemical binding]; other site 1155084000498 Q-loop/lid; other site 1155084000499 ABC transporter signature motif; other site 1155084000500 Walker B; other site 1155084000501 D-loop; other site 1155084000502 H-loop/switch region; other site 1155084000503 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155084000504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084000505 dimer interface [polypeptide binding]; other site 1155084000506 conserved gate region; other site 1155084000507 putative PBP binding loops; other site 1155084000508 ABC-ATPase subunit interface; other site 1155084000509 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1155084000510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084000511 dimer interface [polypeptide binding]; other site 1155084000512 conserved gate region; other site 1155084000513 ABC-ATPase subunit interface; other site 1155084000514 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1155084000515 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1155084000516 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1155084000517 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1155084000518 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1155084000519 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 1155084000520 azoreductase; Reviewed; Region: PRK00170 1155084000521 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155084000522 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155084000523 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155084000524 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1155084000525 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1155084000526 Walker A/P-loop; other site 1155084000527 ATP binding site [chemical binding]; other site 1155084000528 Q-loop/lid; other site 1155084000529 ABC transporter signature motif; other site 1155084000530 Walker B; other site 1155084000531 D-loop; other site 1155084000532 H-loop/switch region; other site 1155084000533 TOBE domain; Region: TOBE; pfam03459 1155084000534 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1155084000535 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1155084000536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084000537 dimer interface [polypeptide binding]; other site 1155084000538 conserved gate region; other site 1155084000539 ABC-ATPase subunit interface; other site 1155084000540 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1155084000541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084000542 dimer interface [polypeptide binding]; other site 1155084000543 conserved gate region; other site 1155084000544 putative PBP binding loops; other site 1155084000545 ABC-ATPase subunit interface; other site 1155084000546 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155084000547 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155084000548 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155084000549 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1155084000550 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1155084000551 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1155084000552 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1155084000553 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1155084000554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1155084000555 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1155084000556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000557 putative substrate translocation pore; other site 1155084000558 Response regulator receiver domain; Region: Response_reg; pfam00072 1155084000559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084000560 active site 1155084000561 phosphorylation site [posttranslational modification] 1155084000562 intermolecular recognition site; other site 1155084000563 dimerization interface [polypeptide binding]; other site 1155084000564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155084000565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155084000566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155084000567 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1155084000568 Histidine kinase; Region: His_kinase; pfam06580 1155084000569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084000570 ATP binding site [chemical binding]; other site 1155084000571 Mg2+ binding site [ion binding]; other site 1155084000572 G-X-G motif; other site 1155084000573 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1155084000574 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1155084000575 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1155084000576 Pyruvate formate lyase 1; Region: PFL1; cd01678 1155084000577 coenzyme A binding site [chemical binding]; other site 1155084000578 active site 1155084000579 catalytic residues [active] 1155084000580 glycine loop; other site 1155084000581 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1155084000582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084000583 FeS/SAM binding site; other site 1155084000584 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1155084000585 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1155084000586 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155084000587 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1155084000588 putative active site [active] 1155084000589 catalytic site [active] 1155084000590 putative metal binding site [ion binding]; other site 1155084000591 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1155084000592 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1155084000593 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1155084000594 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1155084000595 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1155084000596 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1155084000597 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1155084000598 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1155084000599 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1155084000600 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1155084000601 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1155084000602 dimer interface [polypeptide binding]; other site 1155084000603 active site 1155084000604 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1155084000605 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1155084000606 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1155084000607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155084000608 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1155084000609 substrate binding site [chemical binding]; other site 1155084000610 oxyanion hole (OAH) forming residues; other site 1155084000611 trimer interface [polypeptide binding]; other site 1155084000612 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1155084000613 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1155084000614 active site 1155084000615 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1155084000616 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1155084000617 acyl-activating enzyme (AAE) consensus motif; other site 1155084000618 AMP binding site [chemical binding]; other site 1155084000619 active site 1155084000620 CoA binding site [chemical binding]; other site 1155084000621 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1155084000622 Coenzyme A transferase; Region: CoA_trans; smart00882 1155084000623 Coenzyme A transferase; Region: CoA_trans; cl17247 1155084000624 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1155084000625 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1155084000626 catalytic triad [active] 1155084000627 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1155084000628 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1155084000629 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1155084000630 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1155084000631 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1155084000632 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1155084000633 heme-binding site [chemical binding]; other site 1155084000634 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1155084000635 FAD binding pocket [chemical binding]; other site 1155084000636 FAD binding motif [chemical binding]; other site 1155084000637 phosphate binding motif [ion binding]; other site 1155084000638 beta-alpha-beta structure motif; other site 1155084000639 NAD binding pocket [chemical binding]; other site 1155084000640 Heme binding pocket [chemical binding]; other site 1155084000641 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1155084000642 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1155084000643 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155084000644 NAD binding site [chemical binding]; other site 1155084000645 dimer interface [polypeptide binding]; other site 1155084000646 substrate binding site [chemical binding]; other site 1155084000647 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1155084000648 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155084000649 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155084000650 active site turn [active] 1155084000651 phosphorylation site [posttranslational modification] 1155084000652 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1155084000653 active site 1155084000654 tetramer interface [polypeptide binding]; other site 1155084000655 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155084000656 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155084000657 PRD domain; Region: PRD; pfam00874 1155084000658 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155084000659 active site 1155084000660 P-loop; other site 1155084000661 phosphorylation site [posttranslational modification] 1155084000662 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155084000663 active site 1155084000664 phosphorylation site [posttranslational modification] 1155084000665 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155084000666 active site 1155084000667 phosphorylation site [posttranslational modification] 1155084000668 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1155084000669 active site 1155084000670 P-loop; other site 1155084000671 phosphorylation site [posttranslational modification] 1155084000672 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1155084000673 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1155084000674 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155084000675 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1155084000676 putative NAD(P) binding site [chemical binding]; other site 1155084000677 catalytic Zn binding site [ion binding]; other site 1155084000678 structural Zn binding site [ion binding]; other site 1155084000679 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155084000680 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1155084000681 putative NAD(P) binding site [chemical binding]; other site 1155084000682 catalytic Zn binding site [ion binding]; other site 1155084000683 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1155084000684 substrate binding site; other site 1155084000685 dimer interface; other site 1155084000686 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1155084000687 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155084000688 putative NAD(P) binding site [chemical binding]; other site 1155084000689 putative catalytic Zn binding site [ion binding]; other site 1155084000690 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1155084000691 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1155084000692 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084000693 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1155084000694 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1155084000695 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1155084000696 substrate binding site; other site 1155084000697 dimer interface; other site 1155084000698 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1155084000699 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1155084000700 putative NAD(P) binding site [chemical binding]; other site 1155084000701 putative catalytic Zn binding site [ion binding]; other site 1155084000702 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1155084000703 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1155084000704 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155084000705 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155084000706 active site 1155084000707 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1155084000708 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1155084000709 Hemerythrin-like domain; Region: Hr-like; cd12108 1155084000710 Fe binding site [ion binding]; other site 1155084000711 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1155084000712 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1155084000713 Histidine kinase; Region: His_kinase; pfam06580 1155084000714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084000715 Mg2+ binding site [ion binding]; other site 1155084000716 G-X-G motif; other site 1155084000717 two-component response regulator; Provisional; Region: PRK14084 1155084000718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084000719 active site 1155084000720 phosphorylation site [posttranslational modification] 1155084000721 intermolecular recognition site; other site 1155084000722 dimerization interface [polypeptide binding]; other site 1155084000723 LytTr DNA-binding domain; Region: LytTR; pfam04397 1155084000724 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1155084000725 antiholin-like protein LrgB; Provisional; Region: PRK04288 1155084000726 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1155084000727 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1155084000728 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155084000729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155084000730 DNA-binding site [nucleotide binding]; DNA binding site 1155084000731 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1155084000732 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1155084000733 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155084000734 HPr interaction site; other site 1155084000735 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155084000736 active site 1155084000737 phosphorylation site [posttranslational modification] 1155084000738 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1155084000739 beta-galactosidase; Region: BGL; TIGR03356 1155084000740 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155084000741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084000742 S-adenosylmethionine binding site [chemical binding]; other site 1155084000743 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155084000744 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1155084000745 substrate binding site [chemical binding]; other site 1155084000746 dimer interface [polypeptide binding]; other site 1155084000747 ATP binding site [chemical binding]; other site 1155084000748 D-ribose pyranase; Provisional; Region: PRK11797 1155084000749 Sugar transport protein; Region: Sugar_transport; pfam06800 1155084000750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155084000751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155084000752 DNA binding site [nucleotide binding] 1155084000753 domain linker motif; other site 1155084000754 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1155084000755 dimerization interface [polypeptide binding]; other site 1155084000756 ligand binding site [chemical binding]; other site 1155084000757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000759 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1155084000760 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1155084000761 active site 1155084000762 Surface antigen [General function prediction only]; Region: COG3942 1155084000763 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155084000764 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155084000765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155084000766 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1155084000767 Walker A/P-loop; other site 1155084000768 ATP binding site [chemical binding]; other site 1155084000769 Q-loop/lid; other site 1155084000770 ABC transporter signature motif; other site 1155084000771 Walker B; other site 1155084000772 D-loop; other site 1155084000773 H-loop/switch region; other site 1155084000774 Surface antigen [General function prediction only]; Region: COG3942 1155084000775 CHAP domain; Region: CHAP; pfam05257 1155084000776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1155084000777 Predicted membrane protein [Function unknown]; Region: COG1511 1155084000778 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1155084000779 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1155084000780 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1155084000781 Uncharacterized small protein [Function unknown]; Region: COG5417 1155084000782 Predicted membrane protein [Function unknown]; Region: COG4499 1155084000783 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1155084000784 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1155084000785 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1155084000786 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155084000787 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155084000788 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1155084000789 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 1155084000790 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155084000791 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155084000792 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155084000793 Protein of unknown function, DUF600; Region: DUF600; cl04640 1155084000794 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1155084000795 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1155084000796 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1155084000797 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 1155084000798 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155084000799 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155084000800 FtsX-like permease family; Region: FtsX; pfam02687 1155084000801 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155084000802 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155084000803 Walker A/P-loop; other site 1155084000804 ATP binding site [chemical binding]; other site 1155084000805 Q-loop/lid; other site 1155084000806 ABC transporter signature motif; other site 1155084000807 Walker B; other site 1155084000808 D-loop; other site 1155084000809 H-loop/switch region; other site 1155084000810 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1155084000811 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1155084000812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084000813 non-specific DNA binding site [nucleotide binding]; other site 1155084000814 salt bridge; other site 1155084000815 sequence-specific DNA binding site [nucleotide binding]; other site 1155084000816 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155084000817 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1155084000818 substrate binding site [chemical binding]; other site 1155084000819 ATP binding site [chemical binding]; other site 1155084000820 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1155084000821 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1155084000822 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1155084000823 Nucleoside recognition; Region: Gate; pfam07670 1155084000824 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1155084000825 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1155084000826 putative transporter; Provisional; Region: PRK10484 1155084000827 Na binding site [ion binding]; other site 1155084000828 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1155084000829 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1155084000830 inhibitor site; inhibition site 1155084000831 active site 1155084000832 dimer interface [polypeptide binding]; other site 1155084000833 catalytic residue [active] 1155084000834 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1155084000835 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1155084000836 nucleotide binding site [chemical binding]; other site 1155084000837 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1155084000838 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155084000839 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155084000840 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155084000841 putative active site [active] 1155084000842 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1155084000843 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1155084000844 putative active site cavity [active] 1155084000845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1155084000846 Nucleoside recognition; Region: Gate; pfam07670 1155084000847 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1155084000848 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1155084000849 PGAP1-like protein; Region: PGAP1; pfam07819 1155084000850 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1155084000851 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1155084000852 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1155084000853 putative active site [active] 1155084000854 putative FMN binding site [chemical binding]; other site 1155084000855 putative substrate binding site [chemical binding]; other site 1155084000856 putative catalytic residue [active] 1155084000857 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1155084000858 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1155084000859 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1155084000860 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1155084000861 lipoyl attachment site [posttranslational modification]; other site 1155084000862 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1155084000863 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1155084000864 putative ADP-ribose binding site [chemical binding]; other site 1155084000865 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1155084000866 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1155084000867 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155084000868 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1155084000869 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1155084000870 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1155084000871 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1155084000872 NADP binding site [chemical binding]; other site 1155084000873 putative substrate binding site [chemical binding]; other site 1155084000874 active site 1155084000875 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1155084000876 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1155084000877 active site 1155084000878 P-loop; other site 1155084000879 phosphorylation site [posttranslational modification] 1155084000880 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155084000881 active site 1155084000882 phosphorylation site [posttranslational modification] 1155084000883 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155084000884 HTH domain; Region: HTH_11; pfam08279 1155084000885 HTH domain; Region: HTH_11; pfam08279 1155084000886 PRD domain; Region: PRD; pfam00874 1155084000887 PRD domain; Region: PRD; pfam00874 1155084000888 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155084000889 active site 1155084000890 P-loop; other site 1155084000891 phosphorylation site [posttranslational modification] 1155084000892 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155084000893 active site 1155084000894 phosphorylation site [posttranslational modification] 1155084000895 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155084000896 MarR family; Region: MarR_2; pfam12802 1155084000897 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1155084000898 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1155084000899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4815 1155084000900 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1155084000901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000902 putative substrate translocation pore; other site 1155084000903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084000904 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1155084000905 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155084000906 Zn binding site [ion binding]; other site 1155084000907 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1155084000908 Zn binding site [ion binding]; other site 1155084000909 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1155084000910 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1155084000911 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155084000912 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155084000913 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1155084000914 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1155084000915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155084000916 Imelysin; Region: Peptidase_M75; pfam09375 1155084000917 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1155084000918 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1155084000919 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1155084000920 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1155084000921 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1155084000922 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1155084000923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084000924 non-specific DNA binding site [nucleotide binding]; other site 1155084000925 salt bridge; other site 1155084000926 sequence-specific DNA binding site [nucleotide binding]; other site 1155084000927 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1155084000928 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155084000929 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155084000930 Walker A/P-loop; other site 1155084000931 ATP binding site [chemical binding]; other site 1155084000932 Q-loop/lid; other site 1155084000933 ABC transporter signature motif; other site 1155084000934 Walker B; other site 1155084000935 D-loop; other site 1155084000936 H-loop/switch region; other site 1155084000937 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1155084000938 Predicted membrane protein [Function unknown]; Region: COG4292 1155084000939 putative acyltransferase; Provisional; Region: PRK05790 1155084000940 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1155084000941 dimer interface [polypeptide binding]; other site 1155084000942 active site 1155084000943 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1155084000944 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1155084000945 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1155084000946 THF binding site; other site 1155084000947 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1155084000948 substrate binding site [chemical binding]; other site 1155084000949 THF binding site; other site 1155084000950 zinc-binding site [ion binding]; other site 1155084000951 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1155084000952 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1155084000953 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1155084000954 FAD binding site [chemical binding]; other site 1155084000955 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1155084000956 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1155084000957 homodimer interface [polypeptide binding]; other site 1155084000958 substrate-cofactor binding pocket; other site 1155084000959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084000960 catalytic residue [active] 1155084000961 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1155084000962 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1155084000963 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155084000964 catalytic residue [active] 1155084000965 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1155084000966 ParB-like nuclease domain; Region: ParB; smart00470 1155084000967 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1155084000968 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1155084000969 GTP-binding protein YchF; Reviewed; Region: PRK09601 1155084000970 YchF GTPase; Region: YchF; cd01900 1155084000971 G1 box; other site 1155084000972 GTP/Mg2+ binding site [chemical binding]; other site 1155084000973 Switch I region; other site 1155084000974 G2 box; other site 1155084000975 Switch II region; other site 1155084000976 G3 box; other site 1155084000977 G4 box; other site 1155084000978 G5 box; other site 1155084000979 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1155084000980 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1155084000981 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1155084000982 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1155084000983 dimer interface [polypeptide binding]; other site 1155084000984 ssDNA binding site [nucleotide binding]; other site 1155084000985 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155084000986 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1155084000987 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155084000988 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084000989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1155084000990 Predicted membrane protein [Function unknown]; Region: COG3212 1155084000991 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155084000992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1155084000993 non-specific DNA binding site [nucleotide binding]; other site 1155084000994 salt bridge; other site 1155084000995 sequence-specific DNA binding site [nucleotide binding]; other site 1155084000996 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1155084000997 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155084000998 catalytic core [active] 1155084000999 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1155084001000 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1155084001001 catalytic residue [active] 1155084001002 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1155084001003 catalytic residues [active] 1155084001004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155084001005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084001006 peroxiredoxin; Region: AhpC; TIGR03137 1155084001007 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1155084001008 dimer interface [polypeptide binding]; other site 1155084001009 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1155084001010 catalytic triad [active] 1155084001011 peroxidatic and resolving cysteines [active] 1155084001012 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1155084001013 dimer interface [polypeptide binding]; other site 1155084001014 FMN binding site [chemical binding]; other site 1155084001015 NADPH bind site [chemical binding]; other site 1155084001016 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1155084001017 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1155084001018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155084001019 active site 1155084001020 xanthine permease; Region: pbuX; TIGR03173 1155084001021 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1155084001022 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1155084001023 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1155084001024 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1155084001025 active site 1155084001026 GMP synthase; Reviewed; Region: guaA; PRK00074 1155084001027 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1155084001028 AMP/PPi binding site [chemical binding]; other site 1155084001029 candidate oxyanion hole; other site 1155084001030 catalytic triad [active] 1155084001031 potential glutamine specificity residues [chemical binding]; other site 1155084001032 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1155084001033 ATP Binding subdomain [chemical binding]; other site 1155084001034 Ligand Binding sites [chemical binding]; other site 1155084001035 Dimerization subdomain; other site 1155084001036 PemK-like protein; Region: PemK; pfam02452 1155084001037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155084001038 Transposase; Region: HTH_Tnp_1; cl17663 1155084001039 Predicted membrane protein [Function unknown]; Region: COG3759 1155084001040 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1155084001041 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1155084001042 NADP binding site [chemical binding]; other site 1155084001043 superantigen-like protein; Reviewed; Region: PRK13037 1155084001044 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1155084001045 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084001046 superantigen-like protein; Reviewed; Region: PRK13041 1155084001047 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1155084001048 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084001049 superantigen-like protein; Reviewed; Region: PRK13335 1155084001050 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1155084001051 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084001052 superantigen-like protein; Reviewed; Region: PRK13335 1155084001053 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1155084001054 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084001055 superantigen-like protein 5; Reviewed; Region: PRK13035 1155084001056 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1155084001057 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084001058 superantigen-like protein 7; Reviewed; Region: PRK13346 1155084001059 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1155084001060 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084001061 superantigen-like protein; Reviewed; Region: PRK13345 1155084001062 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1155084001063 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084001064 superantigen-like protein; Reviewed; Region: PRK13038 1155084001065 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1155084001066 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084001067 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1155084001068 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1155084001069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084001070 S-adenosylmethionine binding site [chemical binding]; other site 1155084001071 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1155084001072 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1155084001073 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1155084001074 superantigen-like protein; Reviewed; Region: PRK13036 1155084001075 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1155084001076 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084001077 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1155084001078 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1155084001079 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1155084001080 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1155084001081 Protein of unknown function, DUF576; Region: DUF576; cl04553 1155084001082 Protein of unknown function, DUF576; Region: DUF576; cl04553 1155084001083 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1155084001084 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1155084001085 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1155084001086 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1155084001087 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1155084001088 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1155084001089 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1155084001090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1155084001091 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1155084001092 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1155084001093 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1155084001094 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1155084001095 active site 1155084001096 Esterase/lipase [General function prediction only]; Region: COG1647 1155084001097 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155084001098 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1155084001099 Na2 binding site [ion binding]; other site 1155084001100 putative substrate binding site 1 [chemical binding]; other site 1155084001101 Na binding site 1 [ion binding]; other site 1155084001102 putative substrate binding site 2 [chemical binding]; other site 1155084001103 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1155084001104 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1155084001105 dimer interface [polypeptide binding]; other site 1155084001106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084001107 catalytic residue [active] 1155084001108 cystathionine beta-lyase; Provisional; Region: PRK07671 1155084001109 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1155084001110 homodimer interface [polypeptide binding]; other site 1155084001111 substrate-cofactor binding pocket; other site 1155084001112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084001113 catalytic residue [active] 1155084001114 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1155084001115 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1155084001116 Walker A/P-loop; other site 1155084001117 ATP binding site [chemical binding]; other site 1155084001118 Q-loop/lid; other site 1155084001119 ABC transporter signature motif; other site 1155084001120 Walker B; other site 1155084001121 D-loop; other site 1155084001122 H-loop/switch region; other site 1155084001123 NIL domain; Region: NIL; pfam09383 1155084001124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084001125 dimer interface [polypeptide binding]; other site 1155084001126 conserved gate region; other site 1155084001127 ABC-ATPase subunit interface; other site 1155084001128 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1155084001129 LysM domain; Region: LysM; pfam01476 1155084001130 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155084001131 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155084001132 Surface antigen [General function prediction only]; Region: COG3942 1155084001133 CHAP domain; Region: CHAP; pfam05257 1155084001134 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1155084001135 nudix motif; other site 1155084001136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084001137 Coenzyme A binding pocket [chemical binding]; other site 1155084001138 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1155084001139 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1155084001140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155084001141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155084001142 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155084001143 dimerization interface [polypeptide binding]; other site 1155084001144 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1155084001145 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1155084001146 active site 1155084001147 dimer interface [polypeptide binding]; other site 1155084001148 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1155084001149 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1155084001150 active site 1155084001151 FMN binding site [chemical binding]; other site 1155084001152 substrate binding site [chemical binding]; other site 1155084001153 3Fe-4S cluster binding site [ion binding]; other site 1155084001154 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1155084001155 domain interface; other site 1155084001156 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1155084001157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155084001158 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1155084001159 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155084001160 active site turn [active] 1155084001161 phosphorylation site [posttranslational modification] 1155084001162 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155084001163 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155084001164 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155084001165 Ca binding site [ion binding]; other site 1155084001166 active site 1155084001167 catalytic site [active] 1155084001168 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1155084001169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155084001170 DNA-binding site [nucleotide binding]; DNA binding site 1155084001171 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1155084001172 UTRA domain; Region: UTRA; pfam07702 1155084001173 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155084001174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084001175 Coenzyme A binding pocket [chemical binding]; other site 1155084001176 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1155084001177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084001178 Walker A motif; other site 1155084001179 ATP binding site [chemical binding]; other site 1155084001180 Walker B motif; other site 1155084001181 arginine finger; other site 1155084001182 hypothetical protein; Validated; Region: PRK00153 1155084001183 recombination protein RecR; Reviewed; Region: recR; PRK00076 1155084001184 RecR protein; Region: RecR; pfam02132 1155084001185 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1155084001186 putative active site [active] 1155084001187 putative metal-binding site [ion binding]; other site 1155084001188 tetramer interface [polypeptide binding]; other site 1155084001189 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1155084001190 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1155084001191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155084001192 catalytic residue [active] 1155084001193 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1155084001194 thymidylate kinase; Validated; Region: tmk; PRK00698 1155084001195 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1155084001196 TMP-binding site; other site 1155084001197 ATP-binding site [chemical binding]; other site 1155084001198 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1155084001199 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1155084001200 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1155084001201 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1155084001202 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1155084001203 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1155084001204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084001205 S-adenosylmethionine binding site [chemical binding]; other site 1155084001206 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1155084001207 GIY-YIG motif/motif A; other site 1155084001208 putative active site [active] 1155084001209 putative metal binding site [ion binding]; other site 1155084001210 Predicted methyltransferases [General function prediction only]; Region: COG0313 1155084001211 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1155084001212 putative SAM binding site [chemical binding]; other site 1155084001213 putative homodimer interface [polypeptide binding]; other site 1155084001214 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1155084001215 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1155084001216 active site 1155084001217 HIGH motif; other site 1155084001218 KMSKS motif; other site 1155084001219 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1155084001220 tRNA binding surface [nucleotide binding]; other site 1155084001221 anticodon binding site; other site 1155084001222 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1155084001223 dimer interface [polypeptide binding]; other site 1155084001224 putative tRNA-binding site [nucleotide binding]; other site 1155084001225 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1155084001226 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1155084001227 active site 1155084001228 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1155084001229 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1155084001230 putative active site [active] 1155084001231 putative metal binding site [ion binding]; other site 1155084001232 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1155084001233 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1155084001234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084001235 S-adenosylmethionine binding site [chemical binding]; other site 1155084001236 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1155084001237 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1155084001238 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155084001239 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155084001240 pur operon repressor; Provisional; Region: PRK09213 1155084001241 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1155084001242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155084001243 active site 1155084001244 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1155084001245 homotrimer interaction site [polypeptide binding]; other site 1155084001246 putative active site [active] 1155084001247 regulatory protein SpoVG; Reviewed; Region: PRK13259 1155084001248 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1155084001249 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1155084001250 Substrate binding site; other site 1155084001251 Mg++ binding site; other site 1155084001252 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1155084001253 active site 1155084001254 substrate binding site [chemical binding]; other site 1155084001255 CoA binding site [chemical binding]; other site 1155084001256 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1155084001257 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1155084001258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155084001259 active site 1155084001260 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1155084001261 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1155084001262 5S rRNA interface [nucleotide binding]; other site 1155084001263 CTC domain interface [polypeptide binding]; other site 1155084001264 L16 interface [polypeptide binding]; other site 1155084001265 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1155084001266 putative active site [active] 1155084001267 catalytic residue [active] 1155084001268 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1155084001269 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1155084001270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155084001271 ATP binding site [chemical binding]; other site 1155084001272 putative Mg++ binding site [ion binding]; other site 1155084001273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155084001274 nucleotide binding region [chemical binding]; other site 1155084001275 ATP-binding site [chemical binding]; other site 1155084001276 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1155084001277 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155084001278 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155084001279 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1155084001280 putative SAM binding site [chemical binding]; other site 1155084001281 putative homodimer interface [polypeptide binding]; other site 1155084001282 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1155084001283 homodimer interface [polypeptide binding]; other site 1155084001284 metal binding site [ion binding]; metal-binding site 1155084001285 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155084001286 RNA binding surface [nucleotide binding]; other site 1155084001287 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1155084001288 Septum formation initiator; Region: DivIC; pfam04977 1155084001289 hypothetical protein; Provisional; Region: PRK08582 1155084001290 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1155084001291 RNA binding site [nucleotide binding]; other site 1155084001292 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1155084001293 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1155084001294 Ligand Binding Site [chemical binding]; other site 1155084001295 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1155084001296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155084001297 active site 1155084001298 FtsH Extracellular; Region: FtsH_ext; pfam06480 1155084001299 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1155084001300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084001301 Walker A motif; other site 1155084001302 ATP binding site [chemical binding]; other site 1155084001303 Walker B motif; other site 1155084001304 arginine finger; other site 1155084001305 Peptidase family M41; Region: Peptidase_M41; pfam01434 1155084001306 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1155084001307 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1155084001308 dimerization interface [polypeptide binding]; other site 1155084001309 domain crossover interface; other site 1155084001310 redox-dependent activation switch; other site 1155084001311 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1155084001312 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1155084001313 dimer interface [polypeptide binding]; other site 1155084001314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084001315 catalytic residue [active] 1155084001316 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1155084001317 dihydropteroate synthase; Region: DHPS; TIGR01496 1155084001318 substrate binding pocket [chemical binding]; other site 1155084001319 dimer interface [polypeptide binding]; other site 1155084001320 inhibitor binding site; inhibition site 1155084001321 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1155084001322 homooctamer interface [polypeptide binding]; other site 1155084001323 active site 1155084001324 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1155084001325 catalytic center binding site [active] 1155084001326 ATP binding site [chemical binding]; other site 1155084001327 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1155084001328 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1155084001329 dimer interface [polypeptide binding]; other site 1155084001330 putative anticodon binding site; other site 1155084001331 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1155084001332 motif 1; other site 1155084001333 active site 1155084001334 motif 2; other site 1155084001335 motif 3; other site 1155084001336 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1155084001337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155084001338 DNA-binding site [nucleotide binding]; DNA binding site 1155084001339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155084001340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084001341 homodimer interface [polypeptide binding]; other site 1155084001342 catalytic residue [active] 1155084001343 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1155084001344 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1155084001345 active site 1155084001346 multimer interface [polypeptide binding]; other site 1155084001347 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1155084001348 predicted active site [active] 1155084001349 catalytic triad [active] 1155084001350 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1155084001351 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1155084001352 Nucleoside recognition; Region: Gate; pfam07670 1155084001353 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1155084001354 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1155084001355 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1155084001356 UvrB/uvrC motif; Region: UVR; pfam02151 1155084001357 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1155084001358 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1155084001359 ADP binding site [chemical binding]; other site 1155084001360 phosphagen binding site; other site 1155084001361 substrate specificity loop; other site 1155084001362 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1155084001363 Clp amino terminal domain; Region: Clp_N; pfam02861 1155084001364 Clp amino terminal domain; Region: Clp_N; pfam02861 1155084001365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084001366 Walker A motif; other site 1155084001367 ATP binding site [chemical binding]; other site 1155084001368 Walker B motif; other site 1155084001369 arginine finger; other site 1155084001370 UvrB/uvrC motif; Region: UVR; pfam02151 1155084001371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084001372 Walker A motif; other site 1155084001373 ATP binding site [chemical binding]; other site 1155084001374 Walker B motif; other site 1155084001375 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1155084001376 DNA repair protein RadA; Provisional; Region: PRK11823 1155084001377 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1155084001378 Walker A motif/ATP binding site; other site 1155084001379 ATP binding site [chemical binding]; other site 1155084001380 Walker B motif; other site 1155084001381 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1155084001382 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1155084001383 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1155084001384 putative active site [active] 1155084001385 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1155084001386 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1155084001387 active site 1155084001388 HIGH motif; other site 1155084001389 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1155084001390 active site 1155084001391 KMSKS motif; other site 1155084001392 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1155084001393 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1155084001394 trimer interface [polypeptide binding]; other site 1155084001395 active site 1155084001396 substrate binding site [chemical binding]; other site 1155084001397 CoA binding site [chemical binding]; other site 1155084001398 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1155084001399 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1155084001400 active site 1155084001401 HIGH motif; other site 1155084001402 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1155084001403 KMSKS motif; other site 1155084001404 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1155084001405 tRNA binding surface [nucleotide binding]; other site 1155084001406 anticodon binding site; other site 1155084001407 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1155084001408 active site 1155084001409 dimerization interface [polypeptide binding]; other site 1155084001410 metal binding site [ion binding]; metal-binding site 1155084001411 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1155084001412 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1155084001413 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1155084001414 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1155084001415 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1155084001416 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155084001417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1155084001418 DNA binding residues [nucleotide binding] 1155084001419 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1155084001420 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1155084001421 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1155084001422 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1155084001423 putative homodimer interface [polypeptide binding]; other site 1155084001424 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1155084001425 heterodimer interface [polypeptide binding]; other site 1155084001426 homodimer interface [polypeptide binding]; other site 1155084001427 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1155084001428 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1155084001429 23S rRNA interface [nucleotide binding]; other site 1155084001430 L7/L12 interface [polypeptide binding]; other site 1155084001431 putative thiostrepton binding site; other site 1155084001432 L25 interface [polypeptide binding]; other site 1155084001433 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1155084001434 mRNA/rRNA interface [nucleotide binding]; other site 1155084001435 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1155084001436 23S rRNA interface [nucleotide binding]; other site 1155084001437 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1155084001438 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1155084001439 peripheral dimer interface [polypeptide binding]; other site 1155084001440 core dimer interface [polypeptide binding]; other site 1155084001441 L10 interface [polypeptide binding]; other site 1155084001442 L11 interface [polypeptide binding]; other site 1155084001443 putative EF-Tu interaction site [polypeptide binding]; other site 1155084001444 putative EF-G interaction site [polypeptide binding]; other site 1155084001445 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155084001446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084001447 S-adenosylmethionine binding site [chemical binding]; other site 1155084001448 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1155084001449 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1155084001450 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1155084001451 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1155084001452 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1155084001453 RPB10 interaction site [polypeptide binding]; other site 1155084001454 RPB1 interaction site [polypeptide binding]; other site 1155084001455 RPB11 interaction site [polypeptide binding]; other site 1155084001456 RPB3 interaction site [polypeptide binding]; other site 1155084001457 RPB12 interaction site [polypeptide binding]; other site 1155084001458 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1155084001459 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1155084001460 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1155084001461 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1155084001462 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1155084001463 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1155084001464 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1155084001465 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1155084001466 G-loop; other site 1155084001467 DNA binding site [nucleotide binding] 1155084001468 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1155084001469 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1155084001470 S17 interaction site [polypeptide binding]; other site 1155084001471 S8 interaction site; other site 1155084001472 16S rRNA interaction site [nucleotide binding]; other site 1155084001473 streptomycin interaction site [chemical binding]; other site 1155084001474 23S rRNA interaction site [nucleotide binding]; other site 1155084001475 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1155084001476 30S ribosomal protein S7; Validated; Region: PRK05302 1155084001477 elongation factor G; Reviewed; Region: PRK00007 1155084001478 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1155084001479 G1 box; other site 1155084001480 putative GEF interaction site [polypeptide binding]; other site 1155084001481 GTP/Mg2+ binding site [chemical binding]; other site 1155084001482 Switch I region; other site 1155084001483 G2 box; other site 1155084001484 G3 box; other site 1155084001485 Switch II region; other site 1155084001486 G4 box; other site 1155084001487 G5 box; other site 1155084001488 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1155084001489 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1155084001490 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1155084001491 elongation factor Tu; Reviewed; Region: PRK00049 1155084001492 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1155084001493 G1 box; other site 1155084001494 GEF interaction site [polypeptide binding]; other site 1155084001495 GTP/Mg2+ binding site [chemical binding]; other site 1155084001496 Switch I region; other site 1155084001497 G2 box; other site 1155084001498 G3 box; other site 1155084001499 Switch II region; other site 1155084001500 G4 box; other site 1155084001501 G5 box; other site 1155084001502 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1155084001503 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1155084001504 Antibiotic Binding Site [chemical binding]; other site 1155084001505 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155084001506 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1155084001507 metal binding site [ion binding]; metal-binding site 1155084001508 dimer interface [polypeptide binding]; other site 1155084001509 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1155084001510 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1155084001511 substrate-cofactor binding pocket; other site 1155084001512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084001513 catalytic residue [active] 1155084001514 chaperone protein HchA; Provisional; Region: PRK04155 1155084001515 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1155084001516 conserved cys residue [active] 1155084001517 ribulokinase; Provisional; Region: PRK04123 1155084001518 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1155084001519 N- and C-terminal domain interface [polypeptide binding]; other site 1155084001520 active site 1155084001521 MgATP binding site [chemical binding]; other site 1155084001522 catalytic site [active] 1155084001523 metal binding site [ion binding]; metal-binding site 1155084001524 carbohydrate binding site [chemical binding]; other site 1155084001525 homodimer interface [polypeptide binding]; other site 1155084001526 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1155084001527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155084001528 NAD(P) binding site [chemical binding]; other site 1155084001529 active site 1155084001530 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1155084001531 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1155084001532 homodimer interface [polypeptide binding]; other site 1155084001533 substrate-cofactor binding pocket; other site 1155084001534 catalytic residue [active] 1155084001535 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1155084001536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084001537 motif II; other site 1155084001538 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1155084001539 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1155084001540 Substrate-binding site [chemical binding]; other site 1155084001541 Substrate specificity [chemical binding]; other site 1155084001542 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1155084001543 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1155084001544 Substrate-binding site [chemical binding]; other site 1155084001545 Substrate specificity [chemical binding]; other site 1155084001546 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1155084001547 nucleoside/Zn binding site; other site 1155084001548 dimer interface [polypeptide binding]; other site 1155084001549 catalytic motif [active] 1155084001550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084001551 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155084001552 active site 1155084001553 motif I; other site 1155084001554 motif II; other site 1155084001555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084001556 Predicted flavoprotein [General function prediction only]; Region: COG0431 1155084001557 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155084001558 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084001559 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1155084001560 Cna protein B-type domain; Region: Cna_B; pfam05738 1155084001561 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1155084001562 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084001563 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1155084001564 Cna protein B-type domain; Region: Cna_B; pfam05738 1155084001565 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1155084001566 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1155084001567 Cna protein B-type domain; Region: Cna_B; pfam05738 1155084001568 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1155084001569 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1155084001570 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084001571 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1155084001572 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1155084001573 Cna protein B-type domain; Region: Cna_B; pfam05738 1155084001574 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1155084001575 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1155084001576 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1155084001577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155084001578 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1155084001579 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1155084001580 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155084001581 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1155084001582 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1155084001583 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1155084001584 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1155084001585 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1155084001586 active site 1155084001587 trimer interface [polypeptide binding]; other site 1155084001588 allosteric site; other site 1155084001589 active site lid [active] 1155084001590 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1155084001591 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1155084001592 active site 1155084001593 dimer interface [polypeptide binding]; other site 1155084001594 magnesium binding site [ion binding]; other site 1155084001595 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1155084001596 tetramer interface [polypeptide binding]; other site 1155084001597 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155084001598 active site 1155084001599 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1155084001600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084001601 motif II; other site 1155084001602 proline/glycine betaine transporter; Provisional; Region: PRK10642 1155084001603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084001604 putative substrate translocation pore; other site 1155084001605 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1155084001606 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1155084001607 acyl-activating enzyme (AAE) consensus motif; other site 1155084001608 AMP binding site [chemical binding]; other site 1155084001609 active site 1155084001610 CoA binding site [chemical binding]; other site 1155084001611 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1155084001612 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1155084001613 dimer interface [polypeptide binding]; other site 1155084001614 active site 1155084001615 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1155084001616 dimer interface [polypeptide binding]; other site 1155084001617 substrate binding site [chemical binding]; other site 1155084001618 ATP binding site [chemical binding]; other site 1155084001619 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1155084001620 ligand binding site [chemical binding]; other site 1155084001621 active site 1155084001622 UGI interface [polypeptide binding]; other site 1155084001623 catalytic site [active] 1155084001624 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1155084001625 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1155084001626 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1155084001627 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1155084001628 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1155084001629 putative heme peroxidase; Provisional; Region: PRK12276 1155084001630 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1155084001631 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155084001632 mevalonate kinase; Region: mevalon_kin; TIGR00549 1155084001633 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155084001634 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155084001635 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1155084001636 diphosphomevalonate decarboxylase; Region: PLN02407 1155084001637 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1155084001638 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155084001639 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155084001640 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1155084001641 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1155084001642 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1155084001643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084001644 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155084001645 Predicted transcriptional regulator [Transcription]; Region: COG1959 1155084001646 Transcriptional regulator; Region: Rrf2; pfam02082 1155084001647 LXG domain of WXG superfamily; Region: LXG; pfam04740 1155084001648 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1155084001649 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1155084001650 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1155084001651 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155084001652 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155084001653 active site 1155084001654 catalytic tetrad [active] 1155084001655 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084001656 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1155084001657 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1155084001658 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155084001659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084001660 Coenzyme A binding pocket [chemical binding]; other site 1155084001661 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1155084001662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155084001663 Zn2+ binding site [ion binding]; other site 1155084001664 Mg2+ binding site [ion binding]; other site 1155084001665 YwhD family; Region: YwhD; pfam08741 1155084001666 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1155084001667 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1155084001668 NAD binding site [chemical binding]; other site 1155084001669 substrate binding site [chemical binding]; other site 1155084001670 catalytic Zn binding site [ion binding]; other site 1155084001671 tetramer interface [polypeptide binding]; other site 1155084001672 structural Zn binding site [ion binding]; other site 1155084001673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1155084001674 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1155084001675 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1155084001676 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1155084001677 active site 1155084001678 HIGH motif; other site 1155084001679 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155084001680 KMSK motif region; other site 1155084001681 tRNA binding surface [nucleotide binding]; other site 1155084001682 DALR anticodon binding domain; Region: DALR_1; smart00836 1155084001683 anticodon binding site; other site 1155084001684 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1155084001685 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155084001686 minor groove reading motif; other site 1155084001687 helix-hairpin-helix signature motif; other site 1155084001688 substrate binding pocket [chemical binding]; other site 1155084001689 active site 1155084001690 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1155084001691 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1155084001692 putative binding site residues; other site 1155084001693 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084001694 ABC-ATPase subunit interface; other site 1155084001695 dimer interface [polypeptide binding]; other site 1155084001696 putative PBP binding regions; other site 1155084001697 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1155084001698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084001699 motif II; other site 1155084001700 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1155084001701 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155084001702 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1155084001703 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155084001704 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1155084001705 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155084001706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1155084001707 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1155084001708 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1155084001709 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155084001710 active site 1155084001711 DNA binding site [nucleotide binding] 1155084001712 Int/Topo IB signature motif; other site 1155084001713 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1155084001714 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1155084001715 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1155084001716 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1155084001717 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1155084001718 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1155084001719 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1155084001720 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1155084001721 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1155084001722 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1155084001723 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1155084001724 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1155084001725 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155084001726 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1155084001727 metal binding site [ion binding]; metal-binding site 1155084001728 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155084001729 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084001730 ABC-ATPase subunit interface; other site 1155084001731 dimer interface [polypeptide binding]; other site 1155084001732 putative PBP binding regions; other site 1155084001733 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1155084001734 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1155084001735 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1155084001736 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1155084001737 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1155084001738 FeoA domain; Region: FeoA; pfam04023 1155084001739 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1155084001740 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1155084001741 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1155084001742 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1155084001743 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1155084001744 Walker A/P-loop; other site 1155084001745 ATP binding site [chemical binding]; other site 1155084001746 Q-loop/lid; other site 1155084001747 ABC transporter signature motif; other site 1155084001748 Walker B; other site 1155084001749 D-loop; other site 1155084001750 H-loop/switch region; other site 1155084001751 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1155084001752 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1155084001753 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1155084001754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155084001755 active site 1155084001756 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155084001757 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1155084001758 active site 1155084001759 nucleotide binding site [chemical binding]; other site 1155084001760 HIGH motif; other site 1155084001761 KMSKS motif; other site 1155084001762 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1155084001763 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1155084001764 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1155084001765 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155084001766 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155084001767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084001768 Walker A/P-loop; other site 1155084001769 ATP binding site [chemical binding]; other site 1155084001770 Q-loop/lid; other site 1155084001771 ABC transporter signature motif; other site 1155084001772 Walker B; other site 1155084001773 D-loop; other site 1155084001774 H-loop/switch region; other site 1155084001775 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1155084001776 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1155084001777 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1155084001778 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1155084001779 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1155084001780 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155084001781 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1155084001782 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1155084001783 Walker A/P-loop; other site 1155084001784 ATP binding site [chemical binding]; other site 1155084001785 Q-loop/lid; other site 1155084001786 ABC transporter signature motif; other site 1155084001787 Walker B; other site 1155084001788 D-loop; other site 1155084001789 H-loop/switch region; other site 1155084001790 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155084001791 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084001792 ABC-ATPase subunit interface; other site 1155084001793 dimer interface [polypeptide binding]; other site 1155084001794 putative PBP binding regions; other site 1155084001795 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1155084001796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084001797 ABC-ATPase subunit interface; other site 1155084001798 dimer interface [polypeptide binding]; other site 1155084001799 putative PBP binding regions; other site 1155084001800 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1155084001801 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1155084001802 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1155084001803 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1155084001804 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1155084001805 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1155084001806 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1155084001807 Na binding site [ion binding]; other site 1155084001808 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1155084001809 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1155084001810 substrate binding pocket [chemical binding]; other site 1155084001811 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155084001812 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155084001813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084001814 Coenzyme A binding pocket [chemical binding]; other site 1155084001815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155084001816 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1155084001817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155084001818 NAD(P) binding site [chemical binding]; other site 1155084001819 active site 1155084001820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155084001821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084001822 active site 1155084001823 phosphorylation site [posttranslational modification] 1155084001824 intermolecular recognition site; other site 1155084001825 dimerization interface [polypeptide binding]; other site 1155084001826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155084001827 DNA binding site [nucleotide binding] 1155084001828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155084001829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1155084001830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084001831 ATP binding site [chemical binding]; other site 1155084001832 Mg2+ binding site [ion binding]; other site 1155084001833 G-X-G motif; other site 1155084001834 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155084001835 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155084001836 Walker A/P-loop; other site 1155084001837 ATP binding site [chemical binding]; other site 1155084001838 Q-loop/lid; other site 1155084001839 ABC transporter signature motif; other site 1155084001840 Walker B; other site 1155084001841 D-loop; other site 1155084001842 H-loop/switch region; other site 1155084001843 FtsX-like permease family; Region: FtsX; pfam02687 1155084001844 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1155084001845 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1155084001846 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155084001847 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155084001848 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155084001849 Surface antigen [General function prediction only]; Region: COG3942 1155084001850 CHAP domain; Region: CHAP; pfam05257 1155084001851 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1155084001852 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1155084001853 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155084001854 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1155084001855 hypothetical protein; Provisional; Region: PRK12378 1155084001856 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1155084001857 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1155084001858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155084001859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155084001860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155084001861 dimerization interface [polypeptide binding]; other site 1155084001862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084001863 sugar efflux transporter; Region: 2A0120; TIGR00899 1155084001864 putative substrate translocation pore; other site 1155084001865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1155084001866 Serine incorporator (Serinc); Region: Serinc; pfam03348 1155084001867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155084001868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084001869 Coenzyme A binding pocket [chemical binding]; other site 1155084001870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155084001871 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155084001872 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1155084001873 hypothetical protein; Validated; Region: PRK00124 1155084001874 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1155084001875 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1155084001876 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1155084001877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155084001878 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1155084001879 Walker A/P-loop; other site 1155084001880 ATP binding site [chemical binding]; other site 1155084001881 Q-loop/lid; other site 1155084001882 ABC transporter signature motif; other site 1155084001883 Walker B; other site 1155084001884 D-loop; other site 1155084001885 H-loop/switch region; other site 1155084001886 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1155084001887 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155084001888 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1155084001889 Walker A/P-loop; other site 1155084001890 ATP binding site [chemical binding]; other site 1155084001891 Q-loop/lid; other site 1155084001892 ABC transporter signature motif; other site 1155084001893 Walker B; other site 1155084001894 D-loop; other site 1155084001895 H-loop/switch region; other site 1155084001896 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155084001897 MarR family; Region: MarR; pfam01047 1155084001898 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1155084001899 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1155084001900 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1155084001901 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155084001902 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155084001903 active site 1155084001904 catalytic tetrad [active] 1155084001905 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1155084001906 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1155084001907 transmembrane helices; other site 1155084001908 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1155084001909 DNA photolyase; Region: DNA_photolyase; pfam00875 1155084001910 Predicted membrane protein [Function unknown]; Region: COG4330 1155084001911 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1155084001912 trimer interface [polypeptide binding]; other site 1155084001913 putative Zn binding site [ion binding]; other site 1155084001914 D-galactonate transporter; Region: 2A0114; TIGR00893 1155084001915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084001916 putative substrate translocation pore; other site 1155084001917 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1155084001918 putative deacylase active site [active] 1155084001919 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155084001920 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1155084001921 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155084001922 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1155084001923 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1155084001924 putative substrate binding site [chemical binding]; other site 1155084001925 putative ATP binding site [chemical binding]; other site 1155084001926 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1155084001927 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155084001928 active site 1155084001929 phosphorylation site [posttranslational modification] 1155084001930 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1155084001931 active site 1155084001932 P-loop; other site 1155084001933 phosphorylation site [posttranslational modification] 1155084001934 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155084001935 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1155084001936 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1155084001937 active site 1155084001938 dimer interface [polypeptide binding]; other site 1155084001939 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1155084001940 Domain of unknown function DUF21; Region: DUF21; pfam01595 1155084001941 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1155084001942 Transporter associated domain; Region: CorC_HlyC; pfam03471 1155084001943 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155084001944 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155084001945 active site 1155084001946 catalytic tetrad [active] 1155084001947 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1155084001948 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1155084001949 Ligand binding site; other site 1155084001950 Putative Catalytic site; other site 1155084001951 DXD motif; other site 1155084001952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155084001953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155084001954 dimer interface [polypeptide binding]; other site 1155084001955 phosphorylation site [posttranslational modification] 1155084001956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084001957 ATP binding site [chemical binding]; other site 1155084001958 Mg2+ binding site [ion binding]; other site 1155084001959 G-X-G motif; other site 1155084001960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155084001961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084001962 active site 1155084001963 phosphorylation site [posttranslational modification] 1155084001964 intermolecular recognition site; other site 1155084001965 dimerization interface [polypeptide binding]; other site 1155084001966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155084001967 DNA binding site [nucleotide binding] 1155084001968 DoxX; Region: DoxX; cl17842 1155084001969 Electron transfer DM13; Region: DM13; pfam10517 1155084001970 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1155084001971 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1155084001972 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1155084001973 active site 1155084001974 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1155084001975 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1155084001976 Ligand Binding Site [chemical binding]; other site 1155084001977 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1155084001978 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1155084001979 glutamine binding [chemical binding]; other site 1155084001980 catalytic triad [active] 1155084001981 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1155084001982 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1155084001983 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1155084001984 substrate-cofactor binding pocket; other site 1155084001985 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1155084001986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084001987 catalytic residue [active] 1155084001988 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1155084001989 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1155084001990 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1155084001991 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1155084001992 Sulfatase; Region: Sulfatase; pfam00884 1155084001993 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155084001994 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155084001995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155084001996 ABC transporter; Region: ABC_tran_2; pfam12848 1155084001997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155084001998 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1155084001999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155084002000 ATP binding site [chemical binding]; other site 1155084002001 putative Mg++ binding site [ion binding]; other site 1155084002002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155084002003 nucleotide binding region [chemical binding]; other site 1155084002004 ATP-binding site [chemical binding]; other site 1155084002005 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1155084002006 HRDC domain; Region: HRDC; pfam00570 1155084002007 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1155084002008 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1155084002009 Walker A/P-loop; other site 1155084002010 ATP binding site [chemical binding]; other site 1155084002011 Q-loop/lid; other site 1155084002012 ABC transporter signature motif; other site 1155084002013 Walker B; other site 1155084002014 D-loop; other site 1155084002015 H-loop/switch region; other site 1155084002016 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1155084002017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084002018 dimer interface [polypeptide binding]; other site 1155084002019 conserved gate region; other site 1155084002020 ABC-ATPase subunit interface; other site 1155084002021 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1155084002022 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1155084002023 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1155084002024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155084002025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084002026 homodimer interface [polypeptide binding]; other site 1155084002027 catalytic residue [active] 1155084002028 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1155084002029 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084002030 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1155084002031 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155084002032 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1155084002033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084002034 putative substrate translocation pore; other site 1155084002035 POT family; Region: PTR2; cl17359 1155084002036 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1155084002037 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1155084002038 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1155084002039 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1155084002040 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1155084002041 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1155084002042 active site 1155084002043 dimer interface [polypeptide binding]; other site 1155084002044 catalytic residues [active] 1155084002045 effector binding site; other site 1155084002046 R2 peptide binding site; other site 1155084002047 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1155084002048 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1155084002049 dimer interface [polypeptide binding]; other site 1155084002050 putative radical transfer pathway; other site 1155084002051 diiron center [ion binding]; other site 1155084002052 tyrosyl radical; other site 1155084002053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084002054 ABC-ATPase subunit interface; other site 1155084002055 dimer interface [polypeptide binding]; other site 1155084002056 putative PBP binding regions; other site 1155084002057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084002058 ABC-ATPase subunit interface; other site 1155084002059 dimer interface [polypeptide binding]; other site 1155084002060 putative PBP binding regions; other site 1155084002061 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1155084002062 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1155084002063 Walker A/P-loop; other site 1155084002064 ATP binding site [chemical binding]; other site 1155084002065 Q-loop/lid; other site 1155084002066 ABC transporter signature motif; other site 1155084002067 Walker B; other site 1155084002068 D-loop; other site 1155084002069 H-loop/switch region; other site 1155084002070 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1155084002071 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1155084002072 putative ligand binding residues [chemical binding]; other site 1155084002073 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 1155084002074 CHY zinc finger; Region: zf-CHY; pfam05495 1155084002075 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1155084002076 FAD binding domain; Region: FAD_binding_4; pfam01565 1155084002077 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1155084002078 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1155084002079 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1155084002080 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1155084002081 peptidase T; Region: peptidase-T; TIGR01882 1155084002082 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1155084002083 metal binding site [ion binding]; metal-binding site 1155084002084 dimer interface [polypeptide binding]; other site 1155084002085 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1155084002086 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1155084002087 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1155084002088 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1155084002089 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1155084002090 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1155084002091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1155084002092 metal binding site [ion binding]; metal-binding site 1155084002093 active site 1155084002094 I-site; other site 1155084002095 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1155084002096 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1155084002097 Mg++ binding site [ion binding]; other site 1155084002098 putative catalytic motif [active] 1155084002099 substrate binding site [chemical binding]; other site 1155084002100 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1155084002101 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1155084002102 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1155084002103 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155084002104 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155084002105 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155084002106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155084002107 ATP binding site [chemical binding]; other site 1155084002108 putative Mg++ binding site [ion binding]; other site 1155084002109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155084002110 nucleotide binding region [chemical binding]; other site 1155084002111 ATP-binding site [chemical binding]; other site 1155084002112 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1155084002113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155084002114 active site 1155084002115 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1155084002116 30S subunit binding site; other site 1155084002117 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1155084002118 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1155084002119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1155084002120 nucleotide binding region [chemical binding]; other site 1155084002121 ATP-binding site [chemical binding]; other site 1155084002122 SEC-C motif; Region: SEC-C; pfam02810 1155084002123 peptide chain release factor 2; Provisional; Region: PRK06746 1155084002124 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1155084002125 RF-1 domain; Region: RF-1; pfam00472 1155084002126 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084002127 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1155084002128 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155084002129 Surface antigen [General function prediction only]; Region: COG3942 1155084002130 CHAP domain; Region: CHAP; pfam05257 1155084002131 HD domain; Region: HD_3; cl17350 1155084002132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 1155084002133 excinuclease ABC subunit B; Provisional; Region: PRK05298 1155084002134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155084002135 ATP binding site [chemical binding]; other site 1155084002136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155084002137 nucleotide binding region [chemical binding]; other site 1155084002138 ATP-binding site [chemical binding]; other site 1155084002139 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1155084002140 UvrB/uvrC motif; Region: UVR; pfam02151 1155084002141 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1155084002142 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1155084002143 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1155084002144 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1155084002145 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1155084002146 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1155084002147 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1155084002148 Hpr binding site; other site 1155084002149 active site 1155084002150 homohexamer subunit interaction site [polypeptide binding]; other site 1155084002151 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1155084002152 putative acyl transferase; Provisional; Region: PRK10191 1155084002153 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1155084002154 trimer interface [polypeptide binding]; other site 1155084002155 active site 1155084002156 substrate binding site [chemical binding]; other site 1155084002157 CoA binding site [chemical binding]; other site 1155084002158 TPR repeat; Region: TPR_11; pfam13414 1155084002159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1155084002160 binding surface 1155084002161 TPR motif; other site 1155084002162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155084002163 TPR motif; other site 1155084002164 binding surface 1155084002165 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1155084002166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155084002167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084002168 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1155084002169 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1155084002170 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1155084002171 phosphate binding site [ion binding]; other site 1155084002172 dimer interface [polypeptide binding]; other site 1155084002173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1155084002174 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1155084002175 Clp protease; Region: CLP_protease; pfam00574 1155084002176 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1155084002177 oligomer interface [polypeptide binding]; other site 1155084002178 active site residues [active] 1155084002179 malate dehydrogenase; Provisional; Region: PRK13529 1155084002180 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1155084002181 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1155084002182 NAD(P) binding site [chemical binding]; other site 1155084002183 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1155084002184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155084002185 NAD(P) binding site [chemical binding]; other site 1155084002186 active site 1155084002187 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084002188 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1155084002189 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1155084002190 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1155084002191 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1155084002192 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1155084002193 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1155084002194 Phosphoglycerate kinase; Region: PGK; pfam00162 1155084002195 substrate binding site [chemical binding]; other site 1155084002196 hinge regions; other site 1155084002197 ADP binding site [chemical binding]; other site 1155084002198 catalytic site [active] 1155084002199 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1155084002200 triosephosphate isomerase; Provisional; Region: PRK14565 1155084002201 substrate binding site [chemical binding]; other site 1155084002202 dimer interface [polypeptide binding]; other site 1155084002203 catalytic triad [active] 1155084002204 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1155084002205 phosphoglyceromutase; Provisional; Region: PRK05434 1155084002206 enolase; Provisional; Region: eno; PRK00077 1155084002207 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1155084002208 dimer interface [polypeptide binding]; other site 1155084002209 metal binding site [ion binding]; metal-binding site 1155084002210 substrate binding pocket [chemical binding]; other site 1155084002211 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1155084002212 Esterase/lipase [General function prediction only]; Region: COG1647 1155084002213 ribonuclease R; Region: RNase_R; TIGR02063 1155084002214 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1155084002215 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1155084002216 RNB domain; Region: RNB; pfam00773 1155084002217 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1155084002218 RNA binding site [nucleotide binding]; other site 1155084002219 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1155084002220 SmpB-tmRNA interface; other site 1155084002221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084002222 Coenzyme A binding pocket [chemical binding]; other site 1155084002223 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084002224 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1155084002225 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1155084002226 Staphylococcal nuclease homologues; Region: SNc; smart00318 1155084002227 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1155084002228 Catalytic site; other site 1155084002229 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155084002230 DNA-binding site [nucleotide binding]; DNA binding site 1155084002231 RNA-binding motif; other site 1155084002232 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1155084002233 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1155084002234 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155084002235 catalytic core [active] 1155084002236 Lysine efflux permease [General function prediction only]; Region: COG1279 1155084002237 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1155084002238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155084002239 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1155084002240 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1155084002241 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1155084002242 active site 1155084002243 catalytic residue [active] 1155084002244 dimer interface [polypeptide binding]; other site 1155084002245 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1155084002246 putative FMN binding site [chemical binding]; other site 1155084002247 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155084002248 catalytic residues [active] 1155084002249 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1155084002250 ArsC family; Region: ArsC; pfam03960 1155084002251 putative ArsC-like catalytic residues; other site 1155084002252 putative TRX-like catalytic residues [active] 1155084002253 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1155084002254 lipoyl attachment site [posttranslational modification]; other site 1155084002255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1155084002256 antiporter inner membrane protein; Provisional; Region: PRK11670 1155084002257 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1155084002258 putative active site [active] 1155084002259 putative metal binding site [ion binding]; other site 1155084002260 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155084002261 catalytic residues [active] 1155084002262 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1155084002263 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1155084002264 Walker A/P-loop; other site 1155084002265 ATP binding site [chemical binding]; other site 1155084002266 Q-loop/lid; other site 1155084002267 ABC transporter signature motif; other site 1155084002268 Walker B; other site 1155084002269 D-loop; other site 1155084002270 H-loop/switch region; other site 1155084002271 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1155084002272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084002273 dimer interface [polypeptide binding]; other site 1155084002274 conserved gate region; other site 1155084002275 ABC-ATPase subunit interface; other site 1155084002276 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1155084002277 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1155084002278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1155084002279 Predicted membrane protein [Function unknown]; Region: COG2035 1155084002280 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1155084002281 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1155084002282 Walker A/P-loop; other site 1155084002283 ATP binding site [chemical binding]; other site 1155084002284 Q-loop/lid; other site 1155084002285 ABC transporter signature motif; other site 1155084002286 Walker B; other site 1155084002287 D-loop; other site 1155084002288 H-loop/switch region; other site 1155084002289 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1155084002290 FeS assembly protein SufD; Region: sufD; TIGR01981 1155084002291 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1155084002292 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1155084002293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155084002294 catalytic residue [active] 1155084002295 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1155084002296 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1155084002297 trimerization site [polypeptide binding]; other site 1155084002298 active site 1155084002299 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1155084002300 FeS assembly protein SufB; Region: sufB; TIGR01980 1155084002301 Domain of unknown function DUF21; Region: DUF21; pfam01595 1155084002302 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1155084002303 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1155084002304 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1155084002305 FMN binding site [chemical binding]; other site 1155084002306 substrate binding site [chemical binding]; other site 1155084002307 putative catalytic residue [active] 1155084002308 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1155084002309 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1155084002310 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1155084002311 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1155084002312 active site 1155084002313 metal binding site [ion binding]; metal-binding site 1155084002314 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155084002315 lipoyl synthase; Provisional; Region: PRK05481 1155084002316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084002317 FeS/SAM binding site; other site 1155084002318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1155084002319 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1155084002320 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1155084002321 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1155084002322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084002323 active site 1155084002324 motif I; other site 1155084002325 motif II; other site 1155084002326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084002327 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1155084002328 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1155084002329 dimerization interface [polypeptide binding]; other site 1155084002330 ligand binding site [chemical binding]; other site 1155084002331 NADP binding site [chemical binding]; other site 1155084002332 catalytic site [active] 1155084002333 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1155084002334 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1155084002335 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1155084002336 acyl-activating enzyme (AAE) consensus motif; other site 1155084002337 AMP binding site [chemical binding]; other site 1155084002338 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1155084002339 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1155084002340 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1155084002341 DltD N-terminal region; Region: DltD_N; pfam04915 1155084002342 DltD central region; Region: DltD_M; pfam04918 1155084002343 DltD C-terminal region; Region: DltD_C; pfam04914 1155084002344 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1155084002345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1155084002346 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1155084002347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084002348 hypothetical protein; Provisional; Region: PRK13669 1155084002349 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1155084002350 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1155084002351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084002352 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1155084002353 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1155084002354 interface (dimer of trimers) [polypeptide binding]; other site 1155084002355 Substrate-binding/catalytic site; other site 1155084002356 Zn-binding sites [ion binding]; other site 1155084002357 Predicted permease [General function prediction only]; Region: COG2056 1155084002358 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1155084002359 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1155084002360 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1155084002361 CoenzymeA binding site [chemical binding]; other site 1155084002362 subunit interaction site [polypeptide binding]; other site 1155084002363 PHB binding site; other site 1155084002364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155084002365 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1155084002366 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1155084002367 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1155084002368 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 1155084002369 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1155084002370 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1155084002371 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1155084002372 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1155084002373 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1155084002374 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1155084002375 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1155084002376 Kinase associated protein B; Region: KapB; pfam08810 1155084002377 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1155084002378 active site 1155084002379 general stress protein 13; Validated; Region: PRK08059 1155084002380 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1155084002381 RNA binding site [nucleotide binding]; other site 1155084002382 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1155084002383 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1155084002384 putative active site [active] 1155084002385 putative FMN binding site [chemical binding]; other site 1155084002386 putative substrate binding site [chemical binding]; other site 1155084002387 putative catalytic residue [active] 1155084002388 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1155084002389 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155084002390 inhibitor-cofactor binding pocket; inhibition site 1155084002391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084002392 catalytic residue [active] 1155084002393 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1155084002394 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1155084002395 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1155084002396 NAD(P) binding site [chemical binding]; other site 1155084002397 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155084002398 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1155084002399 active site 1155084002400 catalytic site [active] 1155084002401 metal binding site [ion binding]; metal-binding site 1155084002402 argininosuccinate lyase; Provisional; Region: PRK00855 1155084002403 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1155084002404 active sites [active] 1155084002405 tetramer interface [polypeptide binding]; other site 1155084002406 argininosuccinate synthase; Provisional; Region: PRK13820 1155084002407 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1155084002408 ANP binding site [chemical binding]; other site 1155084002409 Substrate Binding Site II [chemical binding]; other site 1155084002410 Substrate Binding Site I [chemical binding]; other site 1155084002411 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1155084002412 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1155084002413 active site 1155084002414 dimer interface [polypeptide binding]; other site 1155084002415 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1155084002416 dimer interface [polypeptide binding]; other site 1155084002417 active site 1155084002418 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1155084002419 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1155084002420 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155084002421 Catalytic site [active] 1155084002422 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1155084002423 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1155084002424 Catalytic site [active] 1155084002425 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1155084002426 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1155084002427 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1155084002428 Part of AAA domain; Region: AAA_19; pfam13245 1155084002429 Family description; Region: UvrD_C_2; pfam13538 1155084002430 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1155084002431 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1155084002432 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1155084002433 hypothetical protein; Provisional; Region: PRK13673 1155084002434 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155084002435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1155084002436 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1155084002437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155084002438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084002439 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155084002440 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1155084002441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084002442 active site 1155084002443 motif I; other site 1155084002444 motif II; other site 1155084002445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084002446 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1155084002447 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1155084002448 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1155084002449 catalytic triad [active] 1155084002450 catalytic triad [active] 1155084002451 oxyanion hole [active] 1155084002452 Clp amino terminal domain; Region: Clp_N; pfam02861 1155084002453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084002454 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155084002455 Walker A motif; other site 1155084002456 ATP binding site [chemical binding]; other site 1155084002457 Walker B motif; other site 1155084002458 arginine finger; other site 1155084002459 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1155084002460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084002461 Walker A motif; other site 1155084002462 ATP binding site [chemical binding]; other site 1155084002463 Walker B motif; other site 1155084002464 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1155084002465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155084002466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155084002467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155084002468 dimerization interface [polypeptide binding]; other site 1155084002469 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1155084002470 substrate binding site [chemical binding]; other site 1155084002471 MAP domain; Region: MAP; pfam03642 1155084002472 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1155084002473 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1155084002474 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1155084002475 dimer interface [polypeptide binding]; other site 1155084002476 active site 1155084002477 CoA binding pocket [chemical binding]; other site 1155084002478 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1155084002479 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1155084002480 dimer interface [polypeptide binding]; other site 1155084002481 active site 1155084002482 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1155084002483 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155084002484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084002485 dimer interface [polypeptide binding]; other site 1155084002486 conserved gate region; other site 1155084002487 putative PBP binding loops; other site 1155084002488 ABC-ATPase subunit interface; other site 1155084002489 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1155084002490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084002491 dimer interface [polypeptide binding]; other site 1155084002492 conserved gate region; other site 1155084002493 putative PBP binding loops; other site 1155084002494 ABC-ATPase subunit interface; other site 1155084002495 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1155084002496 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084002497 Walker A/P-loop; other site 1155084002498 ATP binding site [chemical binding]; other site 1155084002499 Q-loop/lid; other site 1155084002500 ABC transporter signature motif; other site 1155084002501 Walker B; other site 1155084002502 D-loop; other site 1155084002503 H-loop/switch region; other site 1155084002504 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155084002505 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1155084002506 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084002507 Walker A/P-loop; other site 1155084002508 ATP binding site [chemical binding]; other site 1155084002509 Q-loop/lid; other site 1155084002510 ABC transporter signature motif; other site 1155084002511 Walker B; other site 1155084002512 D-loop; other site 1155084002513 H-loop/switch region; other site 1155084002514 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155084002515 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1155084002516 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1155084002517 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1155084002518 peptide binding site [polypeptide binding]; other site 1155084002519 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155084002520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084002521 ABC-ATPase subunit interface; other site 1155084002522 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1155084002523 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1155084002524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084002525 dimer interface [polypeptide binding]; other site 1155084002526 conserved gate region; other site 1155084002527 putative PBP binding loops; other site 1155084002528 ABC-ATPase subunit interface; other site 1155084002529 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1155084002530 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084002531 Walker A/P-loop; other site 1155084002532 ATP binding site [chemical binding]; other site 1155084002533 Q-loop/lid; other site 1155084002534 ABC transporter signature motif; other site 1155084002535 Walker B; other site 1155084002536 D-loop; other site 1155084002537 H-loop/switch region; other site 1155084002538 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155084002539 potential frameshift: common BLAST hit: gi|384549756|ref|YP_005739008.1| oligopeptide ABC transporter ATP-binding protein 1155084002540 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084002541 Walker A/P-loop; other site 1155084002542 ATP binding site [chemical binding]; other site 1155084002543 Q-loop/lid; other site 1155084002544 ABC transporter signature motif; other site 1155084002545 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1155084002546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084002547 Walker B; other site 1155084002548 D-loop; other site 1155084002549 H-loop/switch region; other site 1155084002550 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155084002551 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1155084002552 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1155084002553 peptide binding site [polypeptide binding]; other site 1155084002554 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1155084002555 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1155084002556 active site 1155084002557 HIGH motif; other site 1155084002558 dimer interface [polypeptide binding]; other site 1155084002559 KMSKS motif; other site 1155084002560 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1155084002561 ArsC family; Region: ArsC; pfam03960 1155084002562 putative catalytic residues [active] 1155084002563 thiol/disulfide switch; other site 1155084002564 adaptor protein; Provisional; Region: PRK02315 1155084002565 Competence protein CoiA-like family; Region: CoiA; cl11541 1155084002566 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1155084002567 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1155084002568 active site 1155084002569 Zn binding site [ion binding]; other site 1155084002570 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1155084002571 Thioredoxin; Region: Thioredoxin_5; pfam13743 1155084002572 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1155084002573 apolar tunnel; other site 1155084002574 heme binding site [chemical binding]; other site 1155084002575 dimerization interface [polypeptide binding]; other site 1155084002576 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1155084002577 putative active site [active] 1155084002578 putative metal binding residues [ion binding]; other site 1155084002579 signature motif; other site 1155084002580 putative triphosphate binding site [ion binding]; other site 1155084002581 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155084002582 synthetase active site [active] 1155084002583 NTP binding site [chemical binding]; other site 1155084002584 metal binding site [ion binding]; metal-binding site 1155084002585 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1155084002586 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1155084002587 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1155084002588 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155084002589 active site 1155084002590 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1155084002591 MgtE intracellular N domain; Region: MgtE_N; smart00924 1155084002592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1155084002593 Divalent cation transporter; Region: MgtE; pfam01769 1155084002594 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1155084002595 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1155084002596 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1155084002597 TrkA-N domain; Region: TrkA_N; pfam02254 1155084002598 TrkA-C domain; Region: TrkA_C; pfam02080 1155084002599 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1155084002600 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1155084002601 NAD binding site [chemical binding]; other site 1155084002602 homotetramer interface [polypeptide binding]; other site 1155084002603 homodimer interface [polypeptide binding]; other site 1155084002604 substrate binding site [chemical binding]; other site 1155084002605 active site 1155084002606 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155084002607 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155084002608 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1155084002609 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1155084002610 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1155084002611 Putative esterase; Region: Esterase; pfam00756 1155084002612 hypothetical protein; Provisional; Region: PRK13679 1155084002613 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1155084002614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084002615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084002616 putative substrate translocation pore; other site 1155084002617 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1155084002618 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1155084002619 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155084002620 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1155084002621 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155084002622 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155084002623 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155084002624 YueH-like protein; Region: YueH; pfam14166 1155084002625 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1155084002626 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1155084002627 G1 box; other site 1155084002628 putative GEF interaction site [polypeptide binding]; other site 1155084002629 GTP/Mg2+ binding site [chemical binding]; other site 1155084002630 Switch I region; other site 1155084002631 G2 box; other site 1155084002632 G3 box; other site 1155084002633 Switch II region; other site 1155084002634 G4 box; other site 1155084002635 G5 box; other site 1155084002636 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1155084002637 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1155084002638 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1155084002639 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1155084002640 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1155084002641 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1155084002642 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1155084002643 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1155084002644 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1155084002645 active site 1155084002646 metal binding site [ion binding]; metal-binding site 1155084002647 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1155084002648 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1155084002649 IDEAL domain; Region: IDEAL; pfam08858 1155084002650 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155084002651 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1155084002652 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1155084002653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1155084002654 CAAX protease self-immunity; Region: Abi; pfam02517 1155084002655 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 1155084002656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1155084002657 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1155084002658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1155084002659 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155084002660 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1155084002661 Walker A/P-loop; other site 1155084002662 ATP binding site [chemical binding]; other site 1155084002663 Q-loop/lid; other site 1155084002664 ABC transporter signature motif; other site 1155084002665 Walker B; other site 1155084002666 D-loop; other site 1155084002667 H-loop/switch region; other site 1155084002668 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155084002669 Predicted membrane protein [Function unknown]; Region: COG2259 1155084002670 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1155084002671 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1155084002672 siderophore binding site; other site 1155084002673 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1155084002674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084002675 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155084002676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155084002677 Coenzyme A binding pocket [chemical binding]; other site 1155084002678 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1155084002679 UbiA prenyltransferase family; Region: UbiA; pfam01040 1155084002680 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1155084002681 isochorismate synthases; Region: isochor_syn; TIGR00543 1155084002682 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1155084002683 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1155084002684 dimer interface [polypeptide binding]; other site 1155084002685 tetramer interface [polypeptide binding]; other site 1155084002686 PYR/PP interface [polypeptide binding]; other site 1155084002687 TPP binding site [chemical binding]; other site 1155084002688 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1155084002689 TPP-binding site; other site 1155084002690 Mysoin-binding motif of peroxisomes; Region: Vezatin; pfam12632 1155084002691 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1155084002692 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1155084002693 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1155084002694 substrate binding site [chemical binding]; other site 1155084002695 oxyanion hole (OAH) forming residues; other site 1155084002696 trimer interface [polypeptide binding]; other site 1155084002697 Staphostatin B; Region: Staphostatin_B; pfam09023 1155084002698 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1155084002699 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1155084002700 aminotransferase A; Validated; Region: PRK07683 1155084002701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155084002702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084002703 homodimer interface [polypeptide binding]; other site 1155084002704 catalytic residue [active] 1155084002705 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1155084002706 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1155084002707 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155084002708 MarR family; Region: MarR; pfam01047 1155084002709 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1155084002710 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1155084002711 amidase catalytic site [active] 1155084002712 Zn binding residues [ion binding]; other site 1155084002713 substrate binding site [chemical binding]; other site 1155084002714 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1155084002715 Lysozyme subfamily 2; Region: LYZ2; smart00047 1155084002716 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1155084002717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084002718 Coenzyme A binding pocket [chemical binding]; other site 1155084002719 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1155084002720 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1155084002721 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155084002722 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155084002723 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1155084002724 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1155084002725 Subunit I/III interface [polypeptide binding]; other site 1155084002726 Subunit III/IV interface [polypeptide binding]; other site 1155084002727 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1155084002728 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1155084002729 D-pathway; other site 1155084002730 Putative ubiquinol binding site [chemical binding]; other site 1155084002731 Low-spin heme (heme b) binding site [chemical binding]; other site 1155084002732 Putative water exit pathway; other site 1155084002733 Binuclear center (heme o3/CuB) [ion binding]; other site 1155084002734 K-pathway; other site 1155084002735 Putative proton exit pathway; other site 1155084002736 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1155084002737 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1155084002738 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1155084002739 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1155084002740 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1155084002741 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1155084002742 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1155084002743 homodimer interface [polypeptide binding]; other site 1155084002744 NADP binding site [chemical binding]; other site 1155084002745 substrate binding site [chemical binding]; other site 1155084002746 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1155084002747 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1155084002748 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1155084002749 NAD binding site [chemical binding]; other site 1155084002750 ATP-grasp domain; Region: ATP-grasp; pfam02222 1155084002751 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1155084002752 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1155084002753 ATP binding site [chemical binding]; other site 1155084002754 active site 1155084002755 substrate binding site [chemical binding]; other site 1155084002756 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1155084002757 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1155084002758 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1155084002759 putative active site [active] 1155084002760 catalytic triad [active] 1155084002761 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1155084002762 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1155084002763 dimerization interface [polypeptide binding]; other site 1155084002764 ATP binding site [chemical binding]; other site 1155084002765 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1155084002766 dimerization interface [polypeptide binding]; other site 1155084002767 ATP binding site [chemical binding]; other site 1155084002768 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1155084002769 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1155084002770 active site 1155084002771 tetramer interface [polypeptide binding]; other site 1155084002772 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155084002773 active site 1155084002774 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1155084002775 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1155084002776 dimerization interface [polypeptide binding]; other site 1155084002777 putative ATP binding site [chemical binding]; other site 1155084002778 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1155084002779 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1155084002780 active site 1155084002781 substrate binding site [chemical binding]; other site 1155084002782 cosubstrate binding site; other site 1155084002783 catalytic site [active] 1155084002784 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1155084002785 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1155084002786 purine monophosphate binding site [chemical binding]; other site 1155084002787 dimer interface [polypeptide binding]; other site 1155084002788 putative catalytic residues [active] 1155084002789 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1155084002790 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1155084002791 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1155084002792 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1155084002793 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1155084002794 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1155084002795 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1155084002796 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1155084002797 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155084002798 Walker A/P-loop; other site 1155084002799 ATP binding site [chemical binding]; other site 1155084002800 Q-loop/lid; other site 1155084002801 ABC transporter signature motif; other site 1155084002802 Walker B; other site 1155084002803 D-loop; other site 1155084002804 H-loop/switch region; other site 1155084002805 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1155084002806 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155084002807 Walker A/P-loop; other site 1155084002808 ATP binding site [chemical binding]; other site 1155084002809 Q-loop/lid; other site 1155084002810 ABC transporter signature motif; other site 1155084002811 Walker B; other site 1155084002812 D-loop; other site 1155084002813 H-loop/switch region; other site 1155084002814 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1155084002815 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1155084002816 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1155084002817 putative RNA binding site [nucleotide binding]; other site 1155084002818 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1155084002819 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1155084002820 dimerization domain swap beta strand [polypeptide binding]; other site 1155084002821 regulatory protein interface [polypeptide binding]; other site 1155084002822 active site 1155084002823 regulatory phosphorylation site [posttranslational modification]; other site 1155084002824 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1155084002825 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1155084002826 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1155084002827 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1155084002828 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1155084002829 catalytic residues [active] 1155084002830 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1155084002831 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1155084002832 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1155084002833 TrkA-N domain; Region: TrkA_N; pfam02254 1155084002834 TrkA-C domain; Region: TrkA_C; pfam02080 1155084002835 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084002836 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1155084002837 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1155084002838 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1155084002839 hypothetical protein; Provisional; Region: PRK13667 1155084002840 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1155084002841 active site 1155084002842 catalytic residues [active] 1155084002843 metal binding site [ion binding]; metal-binding site 1155084002844 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1155084002845 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1155084002846 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1155084002847 TPP-binding site [chemical binding]; other site 1155084002848 tetramer interface [polypeptide binding]; other site 1155084002849 heterodimer interface [polypeptide binding]; other site 1155084002850 phosphorylation loop region [posttranslational modification] 1155084002851 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1155084002852 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1155084002853 alpha subunit interface [polypeptide binding]; other site 1155084002854 TPP binding site [chemical binding]; other site 1155084002855 heterodimer interface [polypeptide binding]; other site 1155084002856 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155084002857 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1155084002858 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155084002859 E3 interaction surface; other site 1155084002860 lipoyl attachment site [posttranslational modification]; other site 1155084002861 e3 binding domain; Region: E3_binding; pfam02817 1155084002862 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155084002863 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1155084002864 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155084002865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084002866 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155084002867 hypothetical protein; Provisional; Region: PRK04387 1155084002868 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155084002869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084002870 non-specific DNA binding site [nucleotide binding]; other site 1155084002871 salt bridge; other site 1155084002872 sequence-specific DNA binding site [nucleotide binding]; other site 1155084002873 Cupin domain; Region: Cupin_2; pfam07883 1155084002874 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1155084002875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084002876 Walker A/P-loop; other site 1155084002877 ATP binding site [chemical binding]; other site 1155084002878 Q-loop/lid; other site 1155084002879 ABC transporter signature motif; other site 1155084002880 Walker B; other site 1155084002881 D-loop; other site 1155084002882 H-loop/switch region; other site 1155084002883 TOBE domain; Region: TOBE_2; pfam08402 1155084002884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084002885 putative PBP binding loops; other site 1155084002886 dimer interface [polypeptide binding]; other site 1155084002887 ABC-ATPase subunit interface; other site 1155084002888 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1155084002889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084002890 dimer interface [polypeptide binding]; other site 1155084002891 conserved gate region; other site 1155084002892 putative PBP binding loops; other site 1155084002893 ABC-ATPase subunit interface; other site 1155084002894 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1155084002895 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 1155084002896 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1155084002897 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1155084002898 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155084002899 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1155084002900 manganese transport protein MntH; Reviewed; Region: PRK00701 1155084002901 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1155084002902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1155084002903 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1155084002904 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1155084002905 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1155084002906 active site 1155084002907 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1155084002908 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1155084002909 G1 box; other site 1155084002910 putative GEF interaction site [polypeptide binding]; other site 1155084002911 GTP/Mg2+ binding site [chemical binding]; other site 1155084002912 Switch I region; other site 1155084002913 G2 box; other site 1155084002914 G3 box; other site 1155084002915 Switch II region; other site 1155084002916 G4 box; other site 1155084002917 G5 box; other site 1155084002918 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1155084002919 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1155084002920 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1155084002921 hypothetical protein; Provisional; Region: PRK13666 1155084002922 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1155084002923 pyruvate carboxylase; Reviewed; Region: PRK12999 1155084002924 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155084002925 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155084002926 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1155084002927 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1155084002928 active site 1155084002929 catalytic residues [active] 1155084002930 metal binding site [ion binding]; metal-binding site 1155084002931 homodimer binding site [polypeptide binding]; other site 1155084002932 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155084002933 carboxyltransferase (CT) interaction site; other site 1155084002934 biotinylation site [posttranslational modification]; other site 1155084002935 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1155084002936 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1155084002937 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1155084002938 UbiA prenyltransferase family; Region: UbiA; pfam01040 1155084002939 Predicted membrane protein [Function unknown]; Region: COG2322 1155084002940 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1155084002941 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1155084002942 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1155084002943 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155084002944 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1155084002945 putative active site [active] 1155084002946 catalytic site [active] 1155084002947 putative metal binding site [ion binding]; other site 1155084002948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1155084002949 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1155084002950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084002951 S-adenosylmethionine binding site [chemical binding]; other site 1155084002952 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1155084002953 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1155084002954 active site 1155084002955 (T/H)XGH motif; other site 1155084002956 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1155084002957 hypothetical protein; Provisional; Region: PRK13670 1155084002958 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1155084002959 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1155084002960 heme uptake protein IsdB; Region: IsdB; TIGR03657 1155084002961 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084002962 NEAr Transporter domain; Region: NEAT; smart00725 1155084002963 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1155084002964 heme-binding site [chemical binding]; other site 1155084002965 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1155084002966 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1155084002967 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1155084002968 heme-binding site [chemical binding]; other site 1155084002969 heme uptake protein IsdC; Region: IsdC; TIGR03656 1155084002970 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1155084002971 heme-binding site [chemical binding]; other site 1155084002972 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1155084002973 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1155084002974 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1155084002975 intersubunit interface [polypeptide binding]; other site 1155084002976 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155084002977 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084002978 ABC-ATPase subunit interface; other site 1155084002979 dimer interface [polypeptide binding]; other site 1155084002980 putative PBP binding regions; other site 1155084002981 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1155084002982 active site 1155084002983 catalytic site [active] 1155084002984 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 1155084002985 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1155084002986 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1155084002987 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1155084002988 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1155084002989 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1155084002990 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1155084002991 dimer interface [polypeptide binding]; other site 1155084002992 motif 1; other site 1155084002993 active site 1155084002994 motif 2; other site 1155084002995 motif 3; other site 1155084002996 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1155084002997 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1155084002998 putative tRNA-binding site [nucleotide binding]; other site 1155084002999 B3/4 domain; Region: B3_4; pfam03483 1155084003000 tRNA synthetase B5 domain; Region: B5; smart00874 1155084003001 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1155084003002 dimer interface [polypeptide binding]; other site 1155084003003 motif 1; other site 1155084003004 motif 3; other site 1155084003005 motif 2; other site 1155084003006 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1155084003007 ribonuclease HIII; Provisional; Region: PRK00996 1155084003008 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1155084003009 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1155084003010 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155084003011 active site 1155084003012 Cell division protein ZapA; Region: ZapA; cl01146 1155084003013 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1155084003014 Colicin V production protein; Region: Colicin_V; pfam02674 1155084003015 hypothetical protein; Provisional; Region: PRK08609 1155084003016 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1155084003017 active site 1155084003018 primer binding site [nucleotide binding]; other site 1155084003019 NTP binding site [chemical binding]; other site 1155084003020 metal binding triad [ion binding]; metal-binding site 1155084003021 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1155084003022 active site 1155084003023 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1155084003024 MutS domain III; Region: MutS_III; pfam05192 1155084003025 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1155084003026 Walker A/P-loop; other site 1155084003027 ATP binding site [chemical binding]; other site 1155084003028 Q-loop/lid; other site 1155084003029 ABC transporter signature motif; other site 1155084003030 Walker B; other site 1155084003031 D-loop; other site 1155084003032 H-loop/switch region; other site 1155084003033 Smr domain; Region: Smr; pfam01713 1155084003034 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155084003035 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155084003036 catalytic residues [active] 1155084003037 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1155084003038 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1155084003039 GIY-YIG motif/motif A; other site 1155084003040 active site 1155084003041 catalytic site [active] 1155084003042 putative DNA binding site [nucleotide binding]; other site 1155084003043 metal binding site [ion binding]; metal-binding site 1155084003044 UvrB/uvrC motif; Region: UVR; pfam02151 1155084003045 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1155084003046 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1155084003047 putative Iron-sulfur protein interface [polypeptide binding]; other site 1155084003048 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1155084003049 proximal heme binding site [chemical binding]; other site 1155084003050 distal heme binding site [chemical binding]; other site 1155084003051 putative dimer interface [polypeptide binding]; other site 1155084003052 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1155084003053 L-aspartate oxidase; Provisional; Region: PRK06175 1155084003054 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1155084003055 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1155084003056 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1155084003057 glutamate racemase; Provisional; Region: PRK00865 1155084003058 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1155084003059 active site 1155084003060 dimerization interface [polypeptide binding]; other site 1155084003061 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1155084003062 active site 1155084003063 metal binding site [ion binding]; metal-binding site 1155084003064 homotetramer interface [polypeptide binding]; other site 1155084003065 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1155084003066 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 1155084003067 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1155084003068 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1155084003069 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1155084003070 superantigen-like protein; Reviewed; Region: PRK13350 1155084003071 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084003072 superantigen-like protein; Reviewed; Region: PRK13349 1155084003073 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084003074 superantigen-like protein; Reviewed; Region: PRK13043 1155084003075 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084003076 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1155084003077 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155084003078 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155084003079 carbamate kinase; Reviewed; Region: PRK12686 1155084003080 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1155084003081 putative substrate binding site [chemical binding]; other site 1155084003082 nucleotide binding site [chemical binding]; other site 1155084003083 nucleotide binding site [chemical binding]; other site 1155084003084 homodimer interface [polypeptide binding]; other site 1155084003085 Predicted membrane protein [Function unknown]; Region: COG1288 1155084003086 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1155084003087 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1155084003088 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1155084003089 gating phenylalanine in ion channel; other site 1155084003090 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1155084003091 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1155084003092 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1155084003093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084003094 motif II; other site 1155084003095 hypothetical protein; Provisional; Region: PRK13688 1155084003096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1155084003097 Coenzyme A binding pocket [chemical binding]; other site 1155084003098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1155084003099 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1155084003100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1155084003101 MraZ protein; Region: MraZ; pfam02381 1155084003102 MraZ protein; Region: MraZ; pfam02381 1155084003103 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1155084003104 MraW methylase family; Region: Methyltransf_5; pfam01795 1155084003105 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1155084003106 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155084003107 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155084003108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155084003109 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1155084003110 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1155084003111 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1155084003112 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1155084003113 Mg++ binding site [ion binding]; other site 1155084003114 putative catalytic motif [active] 1155084003115 putative substrate binding site [chemical binding]; other site 1155084003116 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1155084003117 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1155084003118 NAD binding site [chemical binding]; other site 1155084003119 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155084003120 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155084003121 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1155084003122 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1155084003123 Cell division protein FtsQ; Region: FtsQ; pfam03799 1155084003124 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1155084003125 Cell division protein FtsA; Region: FtsA; smart00842 1155084003126 Cell division protein FtsA; Region: FtsA; pfam14450 1155084003127 cell division protein FtsZ; Validated; Region: PRK09330 1155084003128 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1155084003129 nucleotide binding site [chemical binding]; other site 1155084003130 SulA interaction site; other site 1155084003131 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1155084003132 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1155084003133 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1155084003134 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155084003135 catalytic residue [active] 1155084003136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1155084003137 YGGT family; Region: YGGT; pfam02325 1155084003138 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1155084003139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155084003140 RNA binding surface [nucleotide binding]; other site 1155084003141 DivIVA protein; Region: DivIVA; pfam05103 1155084003142 DivIVA domain; Region: DivI1A_domain; TIGR03544 1155084003143 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1155084003144 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1155084003145 HIGH motif; other site 1155084003146 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155084003147 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1155084003148 active site 1155084003149 KMSKS motif; other site 1155084003150 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1155084003151 tRNA binding surface [nucleotide binding]; other site 1155084003152 anticodon binding site; other site 1155084003153 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1155084003154 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1155084003155 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155084003156 active site 1155084003157 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1155084003158 lipoprotein signal peptidase; Provisional; Region: PRK14787 1155084003159 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1155084003160 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155084003161 RNA binding surface [nucleotide binding]; other site 1155084003162 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155084003163 active site 1155084003164 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1155084003165 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1155084003166 uracil transporter; Provisional; Region: PRK10720 1155084003167 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1155084003168 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155084003169 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155084003170 dihydroorotase; Validated; Region: pyrC; PRK09357 1155084003171 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1155084003172 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1155084003173 active site 1155084003174 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1155084003175 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1155084003176 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1155084003177 catalytic site [active] 1155084003178 subunit interface [polypeptide binding]; other site 1155084003179 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1155084003180 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155084003181 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155084003182 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1155084003183 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155084003184 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155084003185 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1155084003186 IMP binding site; other site 1155084003187 dimer interface [polypeptide binding]; other site 1155084003188 interdomain contacts; other site 1155084003189 partial ornithine binding site; other site 1155084003190 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1155084003191 active site 1155084003192 dimer interface [polypeptide binding]; other site 1155084003193 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155084003194 active site 1155084003195 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1155084003196 dimer interface [polypeptide binding]; other site 1155084003197 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1155084003198 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1155084003199 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1155084003200 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1155084003201 catalytic site [active] 1155084003202 G-X2-G-X-G-K; other site 1155084003203 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1155084003204 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1155084003205 Flavoprotein; Region: Flavoprotein; pfam02441 1155084003206 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1155084003207 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1155084003208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155084003209 ATP binding site [chemical binding]; other site 1155084003210 putative Mg++ binding site [ion binding]; other site 1155084003211 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1155084003212 nucleotide binding region [chemical binding]; other site 1155084003213 ATP-binding site [chemical binding]; other site 1155084003214 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1155084003215 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1155084003216 active site 1155084003217 catalytic residues [active] 1155084003218 metal binding site [ion binding]; metal-binding site 1155084003219 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1155084003220 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1155084003221 putative active site [active] 1155084003222 substrate binding site [chemical binding]; other site 1155084003223 putative cosubstrate binding site; other site 1155084003224 catalytic site [active] 1155084003225 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1155084003226 substrate binding site [chemical binding]; other site 1155084003227 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1155084003228 NusB family; Region: NusB; pfam01029 1155084003229 putative RNA binding site [nucleotide binding]; other site 1155084003230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084003231 S-adenosylmethionine binding site [chemical binding]; other site 1155084003232 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1155084003233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084003234 FeS/SAM binding site; other site 1155084003235 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1155084003236 Protein phosphatase 2C; Region: PP2C; pfam00481 1155084003237 active site 1155084003238 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1155084003239 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1155084003240 active site 1155084003241 ATP binding site [chemical binding]; other site 1155084003242 substrate binding site [chemical binding]; other site 1155084003243 activation loop (A-loop); other site 1155084003244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1155084003245 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155084003246 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155084003247 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1155084003248 Predicted GTPases [General function prediction only]; Region: COG1162 1155084003249 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1155084003250 RNA binding site [nucleotide binding]; other site 1155084003251 homodimer interface [polypeptide binding]; other site 1155084003252 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1155084003253 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1155084003254 GTP/Mg2+ binding site [chemical binding]; other site 1155084003255 G4 box; other site 1155084003256 G5 box; other site 1155084003257 G1 box; other site 1155084003258 Switch I region; other site 1155084003259 G2 box; other site 1155084003260 G3 box; other site 1155084003261 Switch II region; other site 1155084003262 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1155084003263 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1155084003264 substrate binding site [chemical binding]; other site 1155084003265 hexamer interface [polypeptide binding]; other site 1155084003266 metal binding site [ion binding]; metal-binding site 1155084003267 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1155084003268 Thiamine pyrophosphokinase; Region: TPK; cd07995 1155084003269 active site 1155084003270 dimerization interface [polypeptide binding]; other site 1155084003271 thiamine binding site [chemical binding]; other site 1155084003272 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1155084003273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1155084003274 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1155084003275 DAK2 domain; Region: Dak2; pfam02734 1155084003276 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1155084003277 ATP-dependent DNA helicase RecG; Region: recG; TIGR00643 1155084003278 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1155084003279 ssDNA binding site; other site 1155084003280 generic binding surface II; other site 1155084003281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155084003282 ATP binding site [chemical binding]; other site 1155084003283 putative Mg++ binding site [ion binding]; other site 1155084003284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155084003285 nucleotide binding region [chemical binding]; other site 1155084003286 ATP-binding site [chemical binding]; other site 1155084003287 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1155084003288 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1155084003289 active site 2 [active] 1155084003290 active site 1 [active] 1155084003291 putative phosphate acyltransferase; Provisional; Region: PRK05331 1155084003292 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1155084003293 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1155084003294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1155084003295 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1155084003296 NAD(P) binding site [chemical binding]; other site 1155084003297 homotetramer interface [polypeptide binding]; other site 1155084003298 homodimer interface [polypeptide binding]; other site 1155084003299 active site 1155084003300 acyl carrier protein; Provisional; Region: acpP; PRK00982 1155084003301 ribonuclease III; Reviewed; Region: rnc; PRK00102 1155084003302 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1155084003303 dimerization interface [polypeptide binding]; other site 1155084003304 active site 1155084003305 metal binding site [ion binding]; metal-binding site 1155084003306 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1155084003307 dsRNA binding site [nucleotide binding]; other site 1155084003308 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1155084003309 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1155084003310 Walker A/P-loop; other site 1155084003311 ATP binding site [chemical binding]; other site 1155084003312 Q-loop/lid; other site 1155084003313 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1155084003314 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1155084003315 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1155084003316 ABC transporter signature motif; other site 1155084003317 Walker B; other site 1155084003318 D-loop; other site 1155084003319 H-loop/switch region; other site 1155084003320 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1155084003321 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1155084003322 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1155084003323 P loop; other site 1155084003324 GTP binding site [chemical binding]; other site 1155084003325 putative DNA-binding protein; Validated; Region: PRK00118 1155084003326 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1155084003327 signal recognition particle protein; Provisional; Region: PRK10867 1155084003328 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1155084003329 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1155084003330 P loop; other site 1155084003331 GTP binding site [chemical binding]; other site 1155084003332 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1155084003333 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1155084003334 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1155084003335 RimM N-terminal domain; Region: RimM; pfam01782 1155084003336 PRC-barrel domain; Region: PRC; pfam05239 1155084003337 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1155084003338 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1155084003339 Predicted membrane protein [Function unknown]; Region: COG4485 1155084003340 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1155084003341 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1155084003342 GTP/Mg2+ binding site [chemical binding]; other site 1155084003343 G4 box; other site 1155084003344 G5 box; other site 1155084003345 G1 box; other site 1155084003346 Switch I region; other site 1155084003347 G2 box; other site 1155084003348 G3 box; other site 1155084003349 Switch II region; other site 1155084003350 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1155084003351 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155084003352 active site 1155084003353 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1155084003354 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1155084003355 CoA-ligase; Region: Ligase_CoA; pfam00549 1155084003356 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1155084003357 CoA binding domain; Region: CoA_binding; pfam02629 1155084003358 CoA-ligase; Region: Ligase_CoA; pfam00549 1155084003359 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 1155084003360 FemAB family; Region: FemAB; pfam02388 1155084003361 potential frameshift: common BLAST hit: gi|384547491|ref|YP_005736744.1| endopeptidase resistance protein 1155084003362 FemAB family; Region: FemAB; pfam02388 1155084003363 FemAB family; Region: FemAB; pfam02388 1155084003364 DNA protecting protein DprA; Region: dprA; TIGR00732 1155084003365 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1155084003366 DNA topoisomerase I; Validated; Region: PRK05582 1155084003367 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1155084003368 active site 1155084003369 interdomain interaction site; other site 1155084003370 putative metal-binding site [ion binding]; other site 1155084003371 nucleotide binding site [chemical binding]; other site 1155084003372 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155084003373 domain I; other site 1155084003374 DNA binding groove [nucleotide binding] 1155084003375 phosphate binding site [ion binding]; other site 1155084003376 domain II; other site 1155084003377 domain III; other site 1155084003378 nucleotide binding site [chemical binding]; other site 1155084003379 catalytic site [active] 1155084003380 domain IV; other site 1155084003381 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1155084003382 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1155084003383 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1155084003384 Glucose inhibited division protein A; Region: GIDA; pfam01134 1155084003385 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1155084003386 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1155084003387 active site 1155084003388 DNA binding site [nucleotide binding] 1155084003389 Int/Topo IB signature motif; other site 1155084003390 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1155084003391 active site 1155084003392 HslU subunit interaction site [polypeptide binding]; other site 1155084003393 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1155084003394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084003395 Walker A motif; other site 1155084003396 ATP binding site [chemical binding]; other site 1155084003397 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1155084003398 Walker B motif; other site 1155084003399 arginine finger; other site 1155084003400 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155084003401 transcriptional repressor CodY; Validated; Region: PRK04158 1155084003402 CodY GAF-like domain; Region: CodY; pfam06018 1155084003403 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1155084003404 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1155084003405 rRNA interaction site [nucleotide binding]; other site 1155084003406 S8 interaction site; other site 1155084003407 putative laminin-1 binding site; other site 1155084003408 elongation factor Ts; Provisional; Region: tsf; PRK09377 1155084003409 UBA/TS-N domain; Region: UBA; pfam00627 1155084003410 Elongation factor TS; Region: EF_TS; pfam00889 1155084003411 Elongation factor TS; Region: EF_TS; pfam00889 1155084003412 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1155084003413 putative nucleotide binding site [chemical binding]; other site 1155084003414 uridine monophosphate binding site [chemical binding]; other site 1155084003415 homohexameric interface [polypeptide binding]; other site 1155084003416 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1155084003417 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1155084003418 hinge region; other site 1155084003419 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1155084003420 catalytic residue [active] 1155084003421 putative FPP diphosphate binding site; other site 1155084003422 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1155084003423 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1155084003424 putative FPP binding hydrophobic cleft; other site 1155084003425 dimer interface [polypeptide binding]; other site 1155084003426 putative IPP diphosphate binding site; other site 1155084003427 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1155084003428 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1155084003429 RIP metalloprotease RseP; Region: TIGR00054 1155084003430 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1155084003431 active site 1155084003432 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1155084003433 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1155084003434 protein binding site [polypeptide binding]; other site 1155084003435 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1155084003436 putative substrate binding region [chemical binding]; other site 1155084003437 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1155084003438 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1155084003439 dimer interface [polypeptide binding]; other site 1155084003440 motif 1; other site 1155084003441 active site 1155084003442 motif 2; other site 1155084003443 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1155084003444 putative deacylase active site [active] 1155084003445 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1155084003446 active site 1155084003447 motif 3; other site 1155084003448 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1155084003449 anticodon binding site; other site 1155084003450 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1155084003451 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1155084003452 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1155084003453 generic binding surface II; other site 1155084003454 generic binding surface I; other site 1155084003455 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1155084003456 active site 1155084003457 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1155084003458 active site 1155084003459 catalytic site [active] 1155084003460 substrate binding site [chemical binding]; other site 1155084003461 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1155084003462 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1155084003463 Sm and related proteins; Region: Sm_like; cl00259 1155084003464 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1155084003465 putative oligomer interface [polypeptide binding]; other site 1155084003466 putative RNA binding site [nucleotide binding]; other site 1155084003467 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1155084003468 NusA N-terminal domain; Region: NusA_N; pfam08529 1155084003469 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1155084003470 RNA binding site [nucleotide binding]; other site 1155084003471 homodimer interface [polypeptide binding]; other site 1155084003472 NusA-like KH domain; Region: KH_5; pfam13184 1155084003473 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1155084003474 G-X-X-G motif; other site 1155084003475 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1155084003476 putative RNA binding cleft [nucleotide binding]; other site 1155084003477 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1155084003478 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1155084003479 translation initiation factor IF-2; Region: IF-2; TIGR00487 1155084003480 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1155084003481 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1155084003482 G1 box; other site 1155084003483 putative GEF interaction site [polypeptide binding]; other site 1155084003484 GTP/Mg2+ binding site [chemical binding]; other site 1155084003485 Switch I region; other site 1155084003486 G2 box; other site 1155084003487 G3 box; other site 1155084003488 Switch II region; other site 1155084003489 G4 box; other site 1155084003490 G5 box; other site 1155084003491 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1155084003492 Translation-initiation factor 2; Region: IF-2; pfam11987 1155084003493 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1155084003494 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1155084003495 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1155084003496 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1155084003497 RNA binding site [nucleotide binding]; other site 1155084003498 active site 1155084003499 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1155084003500 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1155084003501 active site 1155084003502 Riboflavin kinase; Region: Flavokinase; smart00904 1155084003503 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1155084003504 16S/18S rRNA binding site [nucleotide binding]; other site 1155084003505 S13e-L30e interaction site [polypeptide binding]; other site 1155084003506 25S rRNA binding site [nucleotide binding]; other site 1155084003507 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1155084003508 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1155084003509 RNase E interface [polypeptide binding]; other site 1155084003510 trimer interface [polypeptide binding]; other site 1155084003511 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1155084003512 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1155084003513 RNase E interface [polypeptide binding]; other site 1155084003514 trimer interface [polypeptide binding]; other site 1155084003515 active site 1155084003516 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1155084003517 putative nucleic acid binding region [nucleotide binding]; other site 1155084003518 G-X-X-G motif; other site 1155084003519 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1155084003520 RNA binding site [nucleotide binding]; other site 1155084003521 domain interface; other site 1155084003522 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1155084003523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155084003524 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1155084003525 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1155084003526 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155084003527 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155084003528 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1155084003529 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1155084003530 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1155084003531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1155084003532 DNA-binding site [nucleotide binding]; DNA binding site 1155084003533 UTRA domain; Region: UTRA; pfam07702 1155084003534 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1155084003535 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1155084003536 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1155084003537 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1155084003538 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1155084003539 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1155084003540 classical (c) SDRs; Region: SDR_c; cd05233 1155084003541 NAD(P) binding site [chemical binding]; other site 1155084003542 active site 1155084003543 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1155084003544 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1155084003545 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1155084003546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084003547 non-specific DNA binding site [nucleotide binding]; other site 1155084003548 salt bridge; other site 1155084003549 sequence-specific DNA binding site [nucleotide binding]; other site 1155084003550 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1155084003551 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1155084003552 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1155084003553 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1155084003554 putative MPT binding site; other site 1155084003555 recombinase A; Provisional; Region: recA; PRK09354 1155084003556 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1155084003557 hexamer interface [polypeptide binding]; other site 1155084003558 Walker A motif; other site 1155084003559 ATP binding site [chemical binding]; other site 1155084003560 Walker B motif; other site 1155084003561 phosphodiesterase; Provisional; Region: PRK12704 1155084003562 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155084003563 Zn2+ binding site [ion binding]; other site 1155084003564 Mg2+ binding site [ion binding]; other site 1155084003565 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1155084003566 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1155084003567 putative active site [active] 1155084003568 metal binding site [ion binding]; metal-binding site 1155084003569 homodimer binding site [polypeptide binding]; other site 1155084003570 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1155084003571 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1155084003572 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1155084003573 dimer interface [polypeptide binding]; other site 1155084003574 PYR/PP interface [polypeptide binding]; other site 1155084003575 TPP binding site [chemical binding]; other site 1155084003576 substrate binding site [chemical binding]; other site 1155084003577 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1155084003578 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1155084003579 TPP-binding site [chemical binding]; other site 1155084003580 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1155084003581 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155084003582 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155084003583 Integrase core domain; Region: rve; pfam00665 1155084003584 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1155084003585 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1155084003586 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1155084003587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084003588 FeS/SAM binding site; other site 1155084003589 TRAM domain; Region: TRAM; pfam01938 1155084003590 Predicted membrane protein [Function unknown]; Region: COG4550 1155084003591 Predicted membrane protein [Function unknown]; Region: COG4732 1155084003592 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1155084003593 MutS domain I; Region: MutS_I; pfam01624 1155084003594 MutS domain II; Region: MutS_II; pfam05188 1155084003595 MutS domain III; Region: MutS_III; pfam05192 1155084003596 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1155084003597 Walker A/P-loop; other site 1155084003598 ATP binding site [chemical binding]; other site 1155084003599 Q-loop/lid; other site 1155084003600 ABC transporter signature motif; other site 1155084003601 Walker B; other site 1155084003602 D-loop; other site 1155084003603 H-loop/switch region; other site 1155084003604 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1155084003605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084003606 ATP binding site [chemical binding]; other site 1155084003607 Mg2+ binding site [ion binding]; other site 1155084003608 G-X-G motif; other site 1155084003609 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1155084003610 ATP binding site [chemical binding]; other site 1155084003611 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1155084003612 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 1155084003613 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1155084003614 amphipathic channel; other site 1155084003615 Asn-Pro-Ala signature motifs; other site 1155084003616 glycerol kinase; Provisional; Region: glpK; PRK00047 1155084003617 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1155084003618 N- and C-terminal domain interface [polypeptide binding]; other site 1155084003619 active site 1155084003620 MgATP binding site [chemical binding]; other site 1155084003621 catalytic site [active] 1155084003622 metal binding site [ion binding]; metal-binding site 1155084003623 glycerol binding site [chemical binding]; other site 1155084003624 homotetramer interface [polypeptide binding]; other site 1155084003625 homodimer interface [polypeptide binding]; other site 1155084003626 FBP binding site [chemical binding]; other site 1155084003627 protein IIAGlc interface [polypeptide binding]; other site 1155084003628 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1155084003629 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1155084003630 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155084003631 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 1155084003632 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1155084003633 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1155084003634 bacterial Hfq-like; Region: Hfq; cd01716 1155084003635 hexamer interface [polypeptide binding]; other site 1155084003636 Sm1 motif; other site 1155084003637 RNA binding site [nucleotide binding]; other site 1155084003638 Sm2 motif; other site 1155084003639 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1155084003640 catalytic residues [active] 1155084003641 dimer interface [polypeptide binding]; other site 1155084003642 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1155084003643 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1155084003644 HflX GTPase family; Region: HflX; cd01878 1155084003645 G1 box; other site 1155084003646 GTP/Mg2+ binding site [chemical binding]; other site 1155084003647 Switch I region; other site 1155084003648 G2 box; other site 1155084003649 G3 box; other site 1155084003650 Switch II region; other site 1155084003651 G4 box; other site 1155084003652 G5 box; other site 1155084003653 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1155084003654 Aluminium resistance protein; Region: Alum_res; pfam06838 1155084003655 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1155084003656 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155084003657 DNA binding residues [nucleotide binding] 1155084003658 putative dimer interface [polypeptide binding]; other site 1155084003659 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1155084003660 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1155084003661 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1155084003662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1155084003663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1155084003664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1155084003665 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1155084003666 potential frameshift: common BLAST hit: gi|384868478|ref|YP_005748674.1| transposase 1155084003667 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155084003668 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155084003669 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155084003670 Integrase core domain; Region: rve; pfam00665 1155084003671 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1155084003672 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1155084003673 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1155084003674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155084003675 catalytic residue [active] 1155084003676 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1155084003677 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1155084003678 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1155084003679 putative active site [active] 1155084003680 catalytic site [active] 1155084003681 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1155084003682 putative active site [active] 1155084003683 catalytic site [active] 1155084003684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084003685 Staphylococcal nuclease homologues; Region: SNc; smart00318 1155084003686 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1155084003687 Catalytic site; other site 1155084003688 AAA domain; Region: AAA_11; pfam13086 1155084003689 aspartate kinase; Reviewed; Region: PRK09034 1155084003690 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1155084003691 putative catalytic residues [active] 1155084003692 putative nucleotide binding site [chemical binding]; other site 1155084003693 putative aspartate binding site [chemical binding]; other site 1155084003694 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1155084003695 allosteric regulatory residue; other site 1155084003696 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1155084003697 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1155084003698 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1155084003699 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1155084003700 threonine synthase; Reviewed; Region: PRK06721 1155084003701 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1155084003702 homodimer interface [polypeptide binding]; other site 1155084003703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084003704 catalytic residue [active] 1155084003705 homoserine kinase; Provisional; Region: PRK01212 1155084003706 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1155084003707 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1155084003708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084003709 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1155084003710 active site 1155084003711 motif I; other site 1155084003712 motif II; other site 1155084003713 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1155084003714 lysine transporter; Provisional; Region: PRK10836 1155084003715 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1155084003716 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1155084003717 tetramer interface [polypeptide binding]; other site 1155084003718 heme binding pocket [chemical binding]; other site 1155084003719 NADPH binding site [chemical binding]; other site 1155084003720 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1155084003721 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1155084003722 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1155084003723 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1155084003724 active site 1155084003725 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1155084003726 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1155084003727 LexA repressor; Validated; Region: PRK00215 1155084003728 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155084003729 putative DNA binding site [nucleotide binding]; other site 1155084003730 putative Zn2+ binding site [ion binding]; other site 1155084003731 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1155084003732 Catalytic site [active] 1155084003733 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1155084003734 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1155084003735 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1155084003736 TPP-binding site [chemical binding]; other site 1155084003737 dimer interface [polypeptide binding]; other site 1155084003738 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1155084003739 PYR/PP interface [polypeptide binding]; other site 1155084003740 dimer interface [polypeptide binding]; other site 1155084003741 TPP binding site [chemical binding]; other site 1155084003742 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155084003743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1155084003744 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1155084003745 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1155084003746 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1155084003747 active site 1155084003748 metal binding site [ion binding]; metal-binding site 1155084003749 DNA binding site [nucleotide binding] 1155084003750 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1155084003751 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1155084003752 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1155084003753 Walker A/P-loop; other site 1155084003754 ATP binding site [chemical binding]; other site 1155084003755 Q-loop/lid; other site 1155084003756 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1155084003757 ABC transporter signature motif; other site 1155084003758 Walker B; other site 1155084003759 D-loop; other site 1155084003760 H-loop/switch region; other site 1155084003761 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1155084003762 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1155084003763 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1155084003764 aconitate hydratase; Validated; Region: PRK09277 1155084003765 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1155084003766 substrate binding site [chemical binding]; other site 1155084003767 ligand binding site [chemical binding]; other site 1155084003768 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1155084003769 substrate binding site [chemical binding]; other site 1155084003770 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1155084003771 active site 1155084003772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1155084003773 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1155084003774 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1155084003775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084003776 ATP binding site [chemical binding]; other site 1155084003777 Mg2+ binding site [ion binding]; other site 1155084003778 G-X-G motif; other site 1155084003779 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1155084003780 anchoring element; other site 1155084003781 dimer interface [polypeptide binding]; other site 1155084003782 ATP binding site [chemical binding]; other site 1155084003783 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1155084003784 active site 1155084003785 putative metal-binding site [ion binding]; other site 1155084003786 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1155084003787 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1155084003788 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1155084003789 CAP-like domain; other site 1155084003790 active site 1155084003791 primary dimer interface [polypeptide binding]; other site 1155084003792 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1155084003793 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1155084003794 amino acid carrier protein; Region: agcS; TIGR00835 1155084003795 CAT RNA binding domain; Region: CAT_RBD; smart01061 1155084003796 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155084003797 PRD domain; Region: PRD; pfam00874 1155084003798 PRD domain; Region: PRD; pfam00874 1155084003799 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1155084003800 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1155084003801 Predicted integral membrane protein [Function unknown]; Region: COG0392 1155084003802 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1155084003803 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1155084003804 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1155084003805 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1155084003806 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1155084003807 active site 1 [active] 1155084003808 dimer interface [polypeptide binding]; other site 1155084003809 hexamer interface [polypeptide binding]; other site 1155084003810 active site 2 [active] 1155084003811 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1155084003812 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1155084003813 active site 1155084003814 DNA binding site [nucleotide binding] 1155084003815 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1155084003816 prephenate dehydrogenase; Validated; Region: PRK06545 1155084003817 prephenate dehydrogenase; Validated; Region: PRK08507 1155084003818 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1155084003819 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1155084003820 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1155084003821 putative oligomer interface [polypeptide binding]; other site 1155084003822 putative active site [active] 1155084003823 metal binding site [ion binding]; metal-binding site 1155084003824 anthranilate synthase component I; Provisional; Region: PRK13567 1155084003825 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1155084003826 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1155084003827 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1155084003828 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1155084003829 glutamine binding [chemical binding]; other site 1155084003830 catalytic triad [active] 1155084003831 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1155084003832 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1155084003833 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1155084003834 active site 1155084003835 ribulose/triose binding site [chemical binding]; other site 1155084003836 phosphate binding site [ion binding]; other site 1155084003837 substrate (anthranilate) binding pocket [chemical binding]; other site 1155084003838 product (indole) binding pocket [chemical binding]; other site 1155084003839 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1155084003840 active site 1155084003841 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1155084003842 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1155084003843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084003844 catalytic residue [active] 1155084003845 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1155084003846 substrate binding site [chemical binding]; other site 1155084003847 active site 1155084003848 catalytic residues [active] 1155084003849 heterodimer interface [polypeptide binding]; other site 1155084003850 FemAB family; Region: FemAB; pfam02388 1155084003851 FlxA-like protein; Region: FlxA; pfam14282 1155084003852 FemAB family; Region: FemAB; pfam02388 1155084003853 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1155084003854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084003855 active site 1155084003856 motif I; other site 1155084003857 motif II; other site 1155084003858 SWIM zinc finger; Region: SWIM; pfam04434 1155084003859 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1155084003860 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084003861 Walker A/P-loop; other site 1155084003862 ATP binding site [chemical binding]; other site 1155084003863 Q-loop/lid; other site 1155084003864 ABC transporter signature motif; other site 1155084003865 Walker B; other site 1155084003866 D-loop; other site 1155084003867 H-loop/switch region; other site 1155084003868 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084003869 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1155084003870 Walker A/P-loop; other site 1155084003871 ATP binding site [chemical binding]; other site 1155084003872 Q-loop/lid; other site 1155084003873 ABC transporter signature motif; other site 1155084003874 Walker B; other site 1155084003875 D-loop; other site 1155084003876 H-loop/switch region; other site 1155084003877 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1155084003878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084003879 dimer interface [polypeptide binding]; other site 1155084003880 conserved gate region; other site 1155084003881 putative PBP binding loops; other site 1155084003882 ABC-ATPase subunit interface; other site 1155084003883 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155084003884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084003885 dimer interface [polypeptide binding]; other site 1155084003886 conserved gate region; other site 1155084003887 putative PBP binding loops; other site 1155084003888 ABC-ATPase subunit interface; other site 1155084003889 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1155084003890 oligoendopeptidase F; Region: pepF; TIGR00181 1155084003891 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1155084003892 active site 1155084003893 Zn binding site [ion binding]; other site 1155084003894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1155084003895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1155084003896 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1155084003897 PhoU domain; Region: PhoU; pfam01895 1155084003898 PhoU domain; Region: PhoU; pfam01895 1155084003899 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1155084003900 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1155084003901 Walker A/P-loop; other site 1155084003902 ATP binding site [chemical binding]; other site 1155084003903 Q-loop/lid; other site 1155084003904 ABC transporter signature motif; other site 1155084003905 Walker B; other site 1155084003906 D-loop; other site 1155084003907 H-loop/switch region; other site 1155084003908 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1155084003909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084003910 dimer interface [polypeptide binding]; other site 1155084003911 conserved gate region; other site 1155084003912 putative PBP binding loops; other site 1155084003913 ABC-ATPase subunit interface; other site 1155084003914 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1155084003915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084003916 dimer interface [polypeptide binding]; other site 1155084003917 conserved gate region; other site 1155084003918 ABC-ATPase subunit interface; other site 1155084003919 potential frameshift: common BLAST hit: gi|384869930|ref|YP_005752644.1| Phosphate-binding protein pstS 1155084003920 PBP superfamily domain; Region: PBP_like_2; cl17296 1155084003921 PBP superfamily domain; Region: PBP_like_2; cl17296 1155084003922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1155084003923 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155084003924 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1155084003925 S1 domain; Region: S1_2; pfam13509 1155084003926 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1155084003927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155084003928 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155084003929 ABC transporter; Region: ABC_tran_2; pfam12848 1155084003930 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155084003931 aspartate kinase; Reviewed; Region: PRK06635 1155084003932 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1155084003933 putative nucleotide binding site [chemical binding]; other site 1155084003934 putative catalytic residues [active] 1155084003935 putative Mg ion binding site [ion binding]; other site 1155084003936 putative aspartate binding site [chemical binding]; other site 1155084003937 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1155084003938 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1155084003939 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1155084003940 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1155084003941 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1155084003942 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1155084003943 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1155084003944 dimer interface [polypeptide binding]; other site 1155084003945 active site 1155084003946 catalytic residue [active] 1155084003947 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1155084003948 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1155084003949 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1155084003950 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1155084003951 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1155084003952 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1155084003953 active site 1155084003954 trimer interface [polypeptide binding]; other site 1155084003955 substrate binding site [chemical binding]; other site 1155084003956 CoA binding site [chemical binding]; other site 1155084003957 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155084003958 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1155084003959 metal binding site [ion binding]; metal-binding site 1155084003960 dimer interface [polypeptide binding]; other site 1155084003961 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1155084003962 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1155084003963 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155084003964 catalytic residue [active] 1155084003965 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1155084003966 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1155084003967 active site 1155084003968 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155084003969 substrate binding site [chemical binding]; other site 1155084003970 catalytic residues [active] 1155084003971 dimer interface [polypeptide binding]; other site 1155084003972 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1155084003973 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155084003974 DNA-binding site [nucleotide binding]; DNA binding site 1155084003975 RNA-binding motif; other site 1155084003976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1155084003977 acylphosphatase; Provisional; Region: PRK14431 1155084003978 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1155084003979 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1155084003980 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1155084003981 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1155084003982 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1155084003983 metal ion-dependent adhesion site (MIDAS); other site 1155084003984 MoxR-like ATPases [General function prediction only]; Region: COG0714 1155084003985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084003986 Walker A motif; other site 1155084003987 ATP binding site [chemical binding]; other site 1155084003988 Walker B motif; other site 1155084003989 arginine finger; other site 1155084003990 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155084003991 active site 1155084003992 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155084003993 active site 1155084003994 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1155084003995 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155084003996 E3 interaction surface; other site 1155084003997 lipoyl attachment site [posttranslational modification]; other site 1155084003998 e3 binding domain; Region: E3_binding; pfam02817 1155084003999 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155084004000 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1155084004001 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1155084004002 TPP-binding site [chemical binding]; other site 1155084004003 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1155084004004 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1155084004005 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155084004006 HAMP domain; Region: HAMP; pfam00672 1155084004007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155084004008 dimer interface [polypeptide binding]; other site 1155084004009 phosphorylation site [posttranslational modification] 1155084004010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084004011 ATP binding site [chemical binding]; other site 1155084004012 Mg2+ binding site [ion binding]; other site 1155084004013 G-X-G motif; other site 1155084004014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155084004015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084004016 active site 1155084004017 phosphorylation site [posttranslational modification] 1155084004018 intermolecular recognition site; other site 1155084004019 dimerization interface [polypeptide binding]; other site 1155084004020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155084004021 DNA binding site [nucleotide binding] 1155084004022 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1155084004023 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1155084004024 active site 1155084004025 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1155084004026 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1155084004027 active site 1155084004028 homodimer interface [polypeptide binding]; other site 1155084004029 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1155084004030 Coenzyme A binding pocket [chemical binding]; other site 1155084004031 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1155084004032 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1155084004033 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1155084004034 protein binding site [polypeptide binding]; other site 1155084004035 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1155084004036 Catalytic dyad [active] 1155084004037 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1155084004038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 1155084004039 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1155084004040 HPr interaction site; other site 1155084004041 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155084004042 active site 1155084004043 phosphorylation site [posttranslational modification] 1155084004044 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1155084004045 SelR domain; Region: SelR; pfam01641 1155084004046 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1155084004047 EDD domain protein, DegV family; Region: DegV; TIGR00762 1155084004048 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1155084004049 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1155084004050 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1155084004051 folate binding site [chemical binding]; other site 1155084004052 NADP+ binding site [chemical binding]; other site 1155084004053 thymidylate synthase; Region: thym_sym; TIGR03284 1155084004054 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1155084004055 dimerization interface [polypeptide binding]; other site 1155084004056 active site 1155084004057 Disulphide isomerase; Region: Disulph_isomer; cl05813 1155084004058 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1155084004059 Virulence factor; Region: Virulence_fact; pfam13769 1155084004060 HEAT repeats; Region: HEAT_2; pfam13646 1155084004061 HEAT repeat; Region: HEAT; pfam02985 1155084004062 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1155084004063 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1155084004064 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1155084004065 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1155084004066 RNA/DNA hybrid binding site [nucleotide binding]; other site 1155084004067 active site 1155084004068 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084004069 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1155084004070 GA module; Region: GA; smart00844 1155084004071 GA module; Region: GA; smart00844 1155084004072 GA module; Region: GA; smart00844 1155084004073 GA module; Region: GA; smart00844 1155084004074 GA module; Region: GA; smart00844 1155084004075 GA module; Region: GA; smart00844 1155084004076 GA module; Region: GA; smart00844 1155084004077 GA module; Region: GA; smart00844 1155084004078 GA module; Region: GA; smart00844 1155084004079 GA module; Region: GA; smart00844 1155084004080 GA module; Region: GA; smart00844 1155084004081 GA module; Region: GA; smart00844 1155084004082 GA module; Region: GA; smart00844 1155084004083 GA module; Region: GA; smart00844 1155084004084 GA module; Region: GA; smart00844 1155084004085 GA module; Region: GA; smart00844 1155084004086 GA module; Region: GA; smart00844 1155084004087 GA module; Region: GA; smart00844 1155084004088 GA module; Region: GA; smart00844 1155084004089 GA module; Region: GA; smart00844 1155084004090 GA module; Region: GA; smart00844 1155084004091 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 1155084004092 GA module; Region: GA; smart00844 1155084004093 GA module; Region: GA; smart00844 1155084004094 GA module; Region: GA; pfam01468 1155084004095 GA module; Region: GA; smart00844 1155084004096 GA module; Region: GA; smart00844 1155084004097 GA module; Region: GA; smart00844 1155084004098 GA module; Region: GA; smart00844 1155084004099 GA module; Region: GA; smart00844 1155084004100 GA module; Region: GA; smart00844 1155084004101 GA module; Region: GA; smart00844 1155084004102 GA module; Region: GA; smart00844 1155084004103 GA module; Region: GA; smart00844 1155084004104 GA module; Region: GA; smart00844 1155084004105 GA module; Region: GA; smart00844 1155084004106 GA module; Region: GA; smart00844 1155084004107 GA module; Region: GA; smart00844 1155084004108 GA module; Region: GA; smart00844 1155084004109 GA module; Region: GA; smart00844 1155084004110 GA module; Region: GA; smart00844 1155084004111 GA module; Region: GA; smart00844 1155084004112 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084004113 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084004114 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084004115 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084004116 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084004117 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1155084004118 Amino acid permease; Region: AA_permease_2; pfam13520 1155084004119 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1155084004120 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1155084004121 tetramer interface [polypeptide binding]; other site 1155084004122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084004123 catalytic residue [active] 1155084004124 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1155084004125 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1155084004126 hexamer interface [polypeptide binding]; other site 1155084004127 ligand binding site [chemical binding]; other site 1155084004128 putative active site [active] 1155084004129 NAD(P) binding site [chemical binding]; other site 1155084004130 5'-3' exonuclease; Region: 53EXOc; smart00475 1155084004131 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1155084004132 active site 1155084004133 metal binding site 1 [ion binding]; metal-binding site 1155084004134 putative 5' ssDNA interaction site; other site 1155084004135 metal binding site 3; metal-binding site 1155084004136 metal binding site 2 [ion binding]; metal-binding site 1155084004137 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1155084004138 putative DNA binding site [nucleotide binding]; other site 1155084004139 putative metal binding site [ion binding]; other site 1155084004140 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1155084004141 Dynamin family; Region: Dynamin_N; pfam00350 1155084004142 G1 box; other site 1155084004143 GTP/Mg2+ binding site [chemical binding]; other site 1155084004144 G2 box; other site 1155084004145 Switch I region; other site 1155084004146 G3 box; other site 1155084004147 Switch II region; other site 1155084004148 G4 box; other site 1155084004149 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1155084004150 Dynamin family; Region: Dynamin_N; pfam00350 1155084004151 G1 box; other site 1155084004152 GTP/Mg2+ binding site [chemical binding]; other site 1155084004153 G2 box; other site 1155084004154 Switch I region; other site 1155084004155 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1155084004156 G3 box; other site 1155084004157 Switch II region; other site 1155084004158 GTP/Mg2+ binding site [chemical binding]; other site 1155084004159 G4 box; other site 1155084004160 G5 box; other site 1155084004161 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1155084004162 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1155084004163 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1155084004164 Cobalt transport protein component CbiN; Region: CbiN; cl00842 1155084004165 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1155084004166 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1155084004167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1155084004168 cell division protein GpsB; Provisional; Region: PRK14127 1155084004169 DivIVA domain; Region: DivI1A_domain; TIGR03544 1155084004170 hypothetical protein; Provisional; Region: PRK13660 1155084004171 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1155084004172 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1155084004173 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1155084004174 Transglycosylase; Region: Transgly; pfam00912 1155084004175 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1155084004176 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1155084004177 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155084004178 minor groove reading motif; other site 1155084004179 helix-hairpin-helix signature motif; other site 1155084004180 substrate binding pocket [chemical binding]; other site 1155084004181 active site 1155084004182 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1155084004183 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1155084004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1155084004185 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1155084004186 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1155084004187 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1155084004188 putative dimer interface [polypeptide binding]; other site 1155084004189 putative anticodon binding site; other site 1155084004190 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1155084004191 homodimer interface [polypeptide binding]; other site 1155084004192 motif 1; other site 1155084004193 motif 2; other site 1155084004194 active site 1155084004195 motif 3; other site 1155084004196 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1155084004197 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1155084004198 active site 1155084004199 catalytic site [active] 1155084004200 substrate binding site [chemical binding]; other site 1155084004201 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1155084004202 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1155084004203 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1155084004204 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1155084004205 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1155084004206 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1155084004207 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1155084004208 active site 1155084004209 NTP binding site [chemical binding]; other site 1155084004210 metal binding triad [ion binding]; metal-binding site 1155084004211 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1155084004212 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1155084004213 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1155084004214 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1155084004215 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1155084004216 homodimer interface [polypeptide binding]; other site 1155084004217 metal binding site [ion binding]; metal-binding site 1155084004218 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1155084004219 Predicted membrane protein [Function unknown]; Region: COG4347 1155084004220 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1155084004221 UPF0302 domain; Region: UPF0302; pfam08864 1155084004222 A short protein domain of unknown function; Region: IDEAL; smart00914 1155084004223 TPR repeat; Region: TPR_11; pfam13414 1155084004224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155084004225 binding surface 1155084004226 TPR motif; other site 1155084004227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155084004228 TPR motif; other site 1155084004229 binding surface 1155084004230 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1155084004231 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1155084004232 hinge; other site 1155084004233 active site 1155084004234 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1155084004235 active site 1155084004236 NAD binding site [chemical binding]; other site 1155084004237 metal binding site [ion binding]; metal-binding site 1155084004238 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1155084004239 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1155084004240 Tetramer interface [polypeptide binding]; other site 1155084004241 active site 1155084004242 FMN-binding site [chemical binding]; other site 1155084004243 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1155084004244 active site 1155084004245 multimer interface [polypeptide binding]; other site 1155084004246 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1155084004247 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1155084004248 substrate binding pocket [chemical binding]; other site 1155084004249 chain length determination region; other site 1155084004250 substrate-Mg2+ binding site; other site 1155084004251 catalytic residues [active] 1155084004252 aspartate-rich region 1; other site 1155084004253 active site lid residues [active] 1155084004254 aspartate-rich region 2; other site 1155084004255 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1155084004256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084004257 S-adenosylmethionine binding site [chemical binding]; other site 1155084004258 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1155084004259 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1155084004260 IHF dimer interface [polypeptide binding]; other site 1155084004261 IHF - DNA interface [nucleotide binding]; other site 1155084004262 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1155084004263 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1155084004264 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1155084004265 GTP-binding protein Der; Reviewed; Region: PRK00093 1155084004266 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1155084004267 G1 box; other site 1155084004268 GTP/Mg2+ binding site [chemical binding]; other site 1155084004269 Switch I region; other site 1155084004270 G2 box; other site 1155084004271 Switch II region; other site 1155084004272 G3 box; other site 1155084004273 G4 box; other site 1155084004274 G5 box; other site 1155084004275 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1155084004276 G1 box; other site 1155084004277 GTP/Mg2+ binding site [chemical binding]; other site 1155084004278 Switch I region; other site 1155084004279 G2 box; other site 1155084004280 G3 box; other site 1155084004281 Switch II region; other site 1155084004282 G4 box; other site 1155084004283 G5 box; other site 1155084004284 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1155084004285 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1155084004286 RNA binding site [nucleotide binding]; other site 1155084004287 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1155084004288 RNA binding site [nucleotide binding]; other site 1155084004289 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1155084004290 RNA binding site [nucleotide binding]; other site 1155084004291 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1155084004292 RNA binding site [nucleotide binding]; other site 1155084004293 cytidylate kinase; Provisional; Region: cmk; PRK00023 1155084004294 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1155084004295 CMP-binding site; other site 1155084004296 The sites determining sugar specificity; other site 1155084004297 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1155084004298 active site 1155084004299 homotetramer interface [polypeptide binding]; other site 1155084004300 homodimer interface [polypeptide binding]; other site 1155084004301 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1155084004302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1155084004303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084004304 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1155084004305 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1155084004306 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1155084004307 ATP binding site [chemical binding]; other site 1155084004308 putative Mg++ binding site [ion binding]; other site 1155084004309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155084004310 nucleotide binding region [chemical binding]; other site 1155084004311 ATP-binding site [chemical binding]; other site 1155084004312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1155084004313 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1155084004314 Predicted membrane protein [Function unknown]; Region: COG3601 1155084004315 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1155084004316 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1155084004317 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1155084004318 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1155084004319 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 1155084004320 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1155084004321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155084004322 dimerization interface [polypeptide binding]; other site 1155084004323 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1155084004324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155084004325 dimer interface [polypeptide binding]; other site 1155084004326 phosphorylation site [posttranslational modification] 1155084004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084004328 ATP binding site [chemical binding]; other site 1155084004329 Mg2+ binding site [ion binding]; other site 1155084004330 G-X-G motif; other site 1155084004331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155084004332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084004333 active site 1155084004334 phosphorylation site [posttranslational modification] 1155084004335 intermolecular recognition site; other site 1155084004336 dimerization interface [polypeptide binding]; other site 1155084004337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155084004338 DNA binding site [nucleotide binding] 1155084004339 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1155084004340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155084004341 RNA binding surface [nucleotide binding]; other site 1155084004342 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1155084004343 active site 1155084004344 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1155084004345 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1155084004346 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1155084004347 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1155084004348 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1155084004349 active site 1155084004350 Int/Topo IB signature motif; other site 1155084004351 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155084004352 metal binding site 2 [ion binding]; metal-binding site 1155084004353 putative DNA binding helix; other site 1155084004354 metal binding site 1 [ion binding]; metal-binding site 1155084004355 dimer interface [polypeptide binding]; other site 1155084004356 structural Zn2+ binding site [ion binding]; other site 1155084004357 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1155084004358 dimer interface [polypeptide binding]; other site 1155084004359 ADP-ribose binding site [chemical binding]; other site 1155084004360 active site 1155084004361 nudix motif; other site 1155084004362 metal binding site [ion binding]; metal-binding site 1155084004363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155084004364 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155084004365 active site 1155084004366 catalytic tetrad [active] 1155084004367 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1155084004368 classical (c) SDRs; Region: SDR_c; cd05233 1155084004369 NAD(P) binding site [chemical binding]; other site 1155084004370 active site 1155084004371 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1155084004372 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1155084004373 ribonuclease Z; Region: RNase_Z; TIGR02651 1155084004374 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1155084004375 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1155084004376 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1155084004377 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155084004378 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1155084004379 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1155084004380 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1155084004381 Ca binding site [ion binding]; other site 1155084004382 active site 1155084004383 catalytic site [active] 1155084004384 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155084004385 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155084004386 DNA binding site [nucleotide binding] 1155084004387 domain linker motif; other site 1155084004388 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1155084004389 putative ligand binding site [chemical binding]; other site 1155084004390 putative dimerization interface [polypeptide binding]; other site 1155084004391 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155084004392 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1155084004393 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1155084004394 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1155084004395 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1155084004396 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1155084004397 peptidase T-like protein; Region: PepT-like; TIGR01883 1155084004398 metal binding site [ion binding]; metal-binding site 1155084004399 putative dimer interface [polypeptide binding]; other site 1155084004400 Predicted membrane protein [Function unknown]; Region: COG4129 1155084004401 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1155084004402 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1155084004403 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1155084004404 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1155084004405 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1155084004406 E3 interaction surface; other site 1155084004407 lipoyl attachment site [posttranslational modification]; other site 1155084004408 e3 binding domain; Region: E3_binding; pfam02817 1155084004409 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1155084004410 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1155084004411 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1155084004412 alpha subunit interface [polypeptide binding]; other site 1155084004413 TPP binding site [chemical binding]; other site 1155084004414 heterodimer interface [polypeptide binding]; other site 1155084004415 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1155084004416 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1155084004417 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1155084004418 tetramer interface [polypeptide binding]; other site 1155084004419 TPP-binding site [chemical binding]; other site 1155084004420 heterodimer interface [polypeptide binding]; other site 1155084004421 phosphorylation loop region [posttranslational modification] 1155084004422 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1155084004423 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1155084004424 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084004425 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1155084004426 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1155084004427 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1155084004428 Walker A/P-loop; other site 1155084004429 ATP binding site [chemical binding]; other site 1155084004430 Q-loop/lid; other site 1155084004431 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1155084004432 ABC transporter signature motif; other site 1155084004433 Walker B; other site 1155084004434 D-loop; other site 1155084004435 H-loop/switch region; other site 1155084004436 arginine repressor; Provisional; Region: PRK04280 1155084004437 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1155084004438 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1155084004439 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1155084004440 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1155084004441 substrate binding pocket [chemical binding]; other site 1155084004442 chain length determination region; other site 1155084004443 substrate-Mg2+ binding site; other site 1155084004444 catalytic residues [active] 1155084004445 aspartate-rich region 1; other site 1155084004446 active site lid residues [active] 1155084004447 aspartate-rich region 2; other site 1155084004448 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1155084004449 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1155084004450 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1155084004451 generic binding surface II; other site 1155084004452 generic binding surface I; other site 1155084004453 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1155084004454 putative RNA binding site [nucleotide binding]; other site 1155084004455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1155084004456 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1155084004457 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155084004458 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1155084004459 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1155084004460 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1155084004461 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155084004462 carboxyltransferase (CT) interaction site; other site 1155084004463 biotinylation site [posttranslational modification]; other site 1155084004464 elongation factor P; Validated; Region: PRK00529 1155084004465 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1155084004466 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1155084004467 RNA binding site [nucleotide binding]; other site 1155084004468 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1155084004469 RNA binding site [nucleotide binding]; other site 1155084004470 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1155084004471 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1155084004472 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1155084004473 active site 1155084004474 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1155084004475 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1155084004476 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155084004477 active site residue [active] 1155084004478 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1155084004479 tetramer interface [polypeptide binding]; other site 1155084004480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084004481 catalytic residue [active] 1155084004482 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1155084004483 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1155084004484 tetramer interface [polypeptide binding]; other site 1155084004485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084004486 catalytic residue [active] 1155084004487 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1155084004488 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1155084004489 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1155084004490 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1155084004491 ADP binding site [chemical binding]; other site 1155084004492 magnesium binding site [ion binding]; other site 1155084004493 putative shikimate binding site; other site 1155084004494 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1155084004495 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1155084004496 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1155084004497 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1155084004498 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1155084004499 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1155084004500 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1155084004501 Type II/IV secretion system protein; Region: T2SE; pfam00437 1155084004502 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1155084004503 Walker A motif; other site 1155084004504 ATP binding site [chemical binding]; other site 1155084004505 Walker B motif; other site 1155084004506 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155084004507 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1155084004508 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1155084004509 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1155084004510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1155084004511 Rhomboid family; Region: Rhomboid; pfam01694 1155084004512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155084004513 binding surface 1155084004514 TPR motif; other site 1155084004515 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1155084004516 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1155084004517 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1155084004518 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1155084004519 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1155084004520 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1155084004521 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1155084004522 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1155084004523 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1155084004524 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1155084004525 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155084004526 metal binding site 2 [ion binding]; metal-binding site 1155084004527 putative DNA binding helix; other site 1155084004528 metal binding site 1 [ion binding]; metal-binding site 1155084004529 dimer interface [polypeptide binding]; other site 1155084004530 structural Zn2+ binding site [ion binding]; other site 1155084004531 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1155084004532 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084004533 ABC-ATPase subunit interface; other site 1155084004534 dimer interface [polypeptide binding]; other site 1155084004535 putative PBP binding regions; other site 1155084004536 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1155084004537 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1155084004538 endonuclease IV; Provisional; Region: PRK01060 1155084004539 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1155084004540 AP (apurinic/apyrimidinic) site pocket; other site 1155084004541 DNA interaction; other site 1155084004542 Metal-binding active site; metal-binding site 1155084004543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1155084004544 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1155084004545 ATP binding site [chemical binding]; other site 1155084004546 putative Mg++ binding site [ion binding]; other site 1155084004547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155084004548 nucleotide binding region [chemical binding]; other site 1155084004549 ATP-binding site [chemical binding]; other site 1155084004550 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1155084004551 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1155084004552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1155084004553 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1155084004554 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1155084004555 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1155084004556 Family of unknown function (DUF633); Region: DUF633; pfam04816 1155084004557 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1155084004558 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1155084004559 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1155084004560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155084004561 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1155084004562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155084004563 DNA binding residues [nucleotide binding] 1155084004564 DNA primase, catalytic core; Region: dnaG; TIGR01391 1155084004565 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1155084004566 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1155084004567 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1155084004568 active site 1155084004569 metal binding site [ion binding]; metal-binding site 1155084004570 interdomain interaction site; other site 1155084004571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1155084004572 FOG: CBS domain [General function prediction only]; Region: COG0517 1155084004573 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1155084004574 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1155084004575 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1155084004576 motif 1; other site 1155084004577 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1155084004578 active site 1155084004579 motif 2; other site 1155084004580 motif 3; other site 1155084004581 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1155084004582 anticodon binding site; other site 1155084004583 DNA repair protein RecO; Region: reco; TIGR00613 1155084004584 Recombination protein O N terminal; Region: RecO_N; pfam11967 1155084004585 Recombination protein O C terminal; Region: RecO_C; pfam02565 1155084004586 GTPase Era; Reviewed; Region: era; PRK00089 1155084004587 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1155084004588 G1 box; other site 1155084004589 GTP/Mg2+ binding site [chemical binding]; other site 1155084004590 Switch I region; other site 1155084004591 G2 box; other site 1155084004592 Switch II region; other site 1155084004593 G3 box; other site 1155084004594 G4 box; other site 1155084004595 G5 box; other site 1155084004596 KH domain; Region: KH_2; pfam07650 1155084004597 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1155084004598 active site 1155084004599 catalytic motif [active] 1155084004600 Zn binding site [ion binding]; other site 1155084004601 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1155084004602 metal-binding heat shock protein; Provisional; Region: PRK00016 1155084004603 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1155084004604 PhoH-like protein; Region: PhoH; pfam02562 1155084004605 hypothetical protein; Provisional; Region: PRK13665 1155084004606 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1155084004607 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1155084004608 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1155084004609 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1155084004610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084004611 FeS/SAM binding site; other site 1155084004612 TRAM domain; Region: TRAM; cl01282 1155084004613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1155084004614 RNA methyltransferase, RsmE family; Region: TIGR00046 1155084004615 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1155084004616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084004617 S-adenosylmethionine binding site [chemical binding]; other site 1155084004618 chaperone protein DnaJ; Provisional; Region: PRK14280 1155084004619 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1155084004620 HSP70 interaction site [polypeptide binding]; other site 1155084004621 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1155084004622 substrate binding site [polypeptide binding]; other site 1155084004623 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1155084004624 Zn binding sites [ion binding]; other site 1155084004625 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1155084004626 dimer interface [polypeptide binding]; other site 1155084004627 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1155084004628 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1155084004629 nucleotide binding site [chemical binding]; other site 1155084004630 NEF interaction site [polypeptide binding]; other site 1155084004631 SBD interface [polypeptide binding]; other site 1155084004632 heat shock protein GrpE; Provisional; Region: PRK14140 1155084004633 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1155084004634 dimer interface [polypeptide binding]; other site 1155084004635 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1155084004636 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1155084004637 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1155084004638 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1155084004639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084004640 FeS/SAM binding site; other site 1155084004641 HemN C-terminal domain; Region: HemN_C; pfam06969 1155084004642 GTP-binding protein LepA; Provisional; Region: PRK05433 1155084004643 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1155084004644 G1 box; other site 1155084004645 putative GEF interaction site [polypeptide binding]; other site 1155084004646 GTP/Mg2+ binding site [chemical binding]; other site 1155084004647 Switch I region; other site 1155084004648 G2 box; other site 1155084004649 G3 box; other site 1155084004650 Switch II region; other site 1155084004651 G4 box; other site 1155084004652 G5 box; other site 1155084004653 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1155084004654 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1155084004655 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1155084004656 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1155084004657 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1155084004658 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1155084004659 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1155084004660 Competence protein; Region: Competence; pfam03772 1155084004661 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1155084004662 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1155084004663 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1155084004664 catalytic motif [active] 1155084004665 Zn binding site [ion binding]; other site 1155084004666 comEA protein; Region: comE; TIGR01259 1155084004667 Helix-hairpin-helix motif; Region: HHH; pfam00633 1155084004668 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155084004669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084004670 S-adenosylmethionine binding site [chemical binding]; other site 1155084004671 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1155084004672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155084004673 Zn2+ binding site [ion binding]; other site 1155084004674 Mg2+ binding site [ion binding]; other site 1155084004675 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1155084004676 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1155084004677 active site 1155084004678 (T/H)XGH motif; other site 1155084004679 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1155084004680 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1155084004681 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1155084004682 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1155084004683 shikimate binding site; other site 1155084004684 NAD(P) binding site [chemical binding]; other site 1155084004685 GTPase YqeH; Provisional; Region: PRK13796 1155084004686 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1155084004687 GTP/Mg2+ binding site [chemical binding]; other site 1155084004688 G4 box; other site 1155084004689 G5 box; other site 1155084004690 G1 box; other site 1155084004691 Switch I region; other site 1155084004692 G2 box; other site 1155084004693 G3 box; other site 1155084004694 Switch II region; other site 1155084004695 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1155084004696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084004697 active site 1155084004698 motif I; other site 1155084004699 motif II; other site 1155084004700 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1155084004701 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1155084004702 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1155084004703 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1155084004704 Fic family protein [Function unknown]; Region: COG3177 1155084004705 Fic/DOC family; Region: Fic; pfam02661 1155084004706 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1155084004707 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1155084004708 putative active site [active] 1155084004709 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1155084004710 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1155084004711 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1155084004712 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1155084004713 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1155084004714 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1155084004715 carboxyltransferase (CT) interaction site; other site 1155084004716 biotinylation site [posttranslational modification]; other site 1155084004717 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1155084004718 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1155084004719 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1155084004720 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1155084004721 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1155084004722 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1155084004723 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1155084004724 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1155084004725 Sugar specificity; other site 1155084004726 Pyrimidine base specificity; other site 1155084004727 ATP-binding site [chemical binding]; other site 1155084004728 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1155084004729 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1155084004730 Peptidase family U32; Region: Peptidase_U32; pfam01136 1155084004731 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1155084004732 Peptidase family U32; Region: Peptidase_U32; pfam01136 1155084004733 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1155084004734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084004735 S-adenosylmethionine binding site [chemical binding]; other site 1155084004736 hypothetical protein; Provisional; Region: PRK13678 1155084004737 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1155084004738 hypothetical protein; Provisional; Region: PRK05473 1155084004739 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1155084004740 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1155084004741 motif 1; other site 1155084004742 active site 1155084004743 motif 2; other site 1155084004744 motif 3; other site 1155084004745 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1155084004746 DHHA1 domain; Region: DHHA1; pfam02272 1155084004747 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1155084004748 AAA domain; Region: AAA_30; pfam13604 1155084004749 Family description; Region: UvrD_C_2; pfam13538 1155084004750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155084004751 binding surface 1155084004752 TPR motif; other site 1155084004753 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1155084004754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1155084004755 binding surface 1155084004756 TPR motif; other site 1155084004757 TPR repeat; Region: TPR_11; pfam13414 1155084004758 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1155084004759 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1155084004760 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1155084004761 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1155084004762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155084004763 catalytic residue [active] 1155084004764 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1155084004765 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1155084004766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1155084004767 Predicted transcriptional regulator [Transcription]; Region: COG1959 1155084004768 Transcriptional regulator; Region: Rrf2; pfam02082 1155084004769 recombination factor protein RarA; Reviewed; Region: PRK13342 1155084004770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084004771 Walker A motif; other site 1155084004772 ATP binding site [chemical binding]; other site 1155084004773 Walker B motif; other site 1155084004774 arginine finger; other site 1155084004775 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1155084004776 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1155084004777 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1155084004778 putative ATP binding site [chemical binding]; other site 1155084004779 putative substrate interface [chemical binding]; other site 1155084004780 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1155084004781 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1155084004782 dimer interface [polypeptide binding]; other site 1155084004783 anticodon binding site; other site 1155084004784 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1155084004785 homodimer interface [polypeptide binding]; other site 1155084004786 motif 1; other site 1155084004787 active site 1155084004788 motif 2; other site 1155084004789 GAD domain; Region: GAD; pfam02938 1155084004790 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1155084004791 motif 3; other site 1155084004792 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1155084004793 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1155084004794 dimer interface [polypeptide binding]; other site 1155084004795 motif 1; other site 1155084004796 active site 1155084004797 motif 2; other site 1155084004798 motif 3; other site 1155084004799 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1155084004800 anticodon binding site; other site 1155084004801 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1155084004802 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1155084004803 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1155084004804 active site 1155084004805 metal binding site [ion binding]; metal-binding site 1155084004806 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1155084004807 putative active site [active] 1155084004808 dimerization interface [polypeptide binding]; other site 1155084004809 putative tRNAtyr binding site [nucleotide binding]; other site 1155084004810 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1155084004811 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155084004812 Zn2+ binding site [ion binding]; other site 1155084004813 Mg2+ binding site [ion binding]; other site 1155084004814 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155084004815 synthetase active site [active] 1155084004816 NTP binding site [chemical binding]; other site 1155084004817 metal binding site [ion binding]; metal-binding site 1155084004818 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1155084004819 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1155084004820 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155084004821 active site 1155084004822 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1155084004823 DHH family; Region: DHH; pfam01368 1155084004824 DHHA1 domain; Region: DHHA1; pfam02272 1155084004825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1155084004826 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1155084004827 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1155084004828 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1155084004829 Protein export membrane protein; Region: SecD_SecF; pfam02355 1155084004830 Preprotein translocase subunit; Region: YajC; pfam02699 1155084004831 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1155084004832 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1155084004833 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1155084004834 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1155084004835 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1155084004836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084004837 Walker A motif; other site 1155084004838 ATP binding site [chemical binding]; other site 1155084004839 Walker B motif; other site 1155084004840 arginine finger; other site 1155084004841 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1155084004842 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1155084004843 RuvA N terminal domain; Region: RuvA_N; pfam01330 1155084004844 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1155084004845 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 1155084004846 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1155084004847 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1155084004848 GTP1/OBG; Region: GTP1_OBG; pfam01018 1155084004849 Obg GTPase; Region: Obg; cd01898 1155084004850 G1 box; other site 1155084004851 GTP/Mg2+ binding site [chemical binding]; other site 1155084004852 Switch I region; other site 1155084004853 G2 box; other site 1155084004854 G3 box; other site 1155084004855 Switch II region; other site 1155084004856 G4 box; other site 1155084004857 G5 box; other site 1155084004858 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1155084004859 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1155084004860 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1155084004861 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1155084004862 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1155084004863 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1155084004864 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1155084004865 rod shape-determining protein MreC; Region: MreC; pfam04085 1155084004866 hypothetical protein; Reviewed; Region: PRK00024 1155084004867 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1155084004868 MPN+ (JAMM) motif; other site 1155084004869 Zinc-binding site [ion binding]; other site 1155084004870 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1155084004871 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1155084004872 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1155084004873 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155084004874 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155084004875 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1155084004876 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1155084004877 active site 1155084004878 HIGH motif; other site 1155084004879 nucleotide binding site [chemical binding]; other site 1155084004880 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155084004881 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1155084004882 active site 1155084004883 KMSKS motif; other site 1155084004884 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1155084004885 tRNA binding surface [nucleotide binding]; other site 1155084004886 anticodon binding site; other site 1155084004887 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1155084004888 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1155084004889 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1155084004890 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1155084004891 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1155084004892 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1155084004893 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155084004894 inhibitor-cofactor binding pocket; inhibition site 1155084004895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084004896 catalytic residue [active] 1155084004897 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1155084004898 dimer interface [polypeptide binding]; other site 1155084004899 active site 1155084004900 Schiff base residues; other site 1155084004901 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1155084004902 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1155084004903 active site 1155084004904 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1155084004905 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1155084004906 domain interfaces; other site 1155084004907 active site 1155084004908 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 1155084004909 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1155084004910 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1155084004911 tRNA; other site 1155084004912 putative tRNA binding site [nucleotide binding]; other site 1155084004913 putative NADP binding site [chemical binding]; other site 1155084004914 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1155084004915 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1155084004916 G1 box; other site 1155084004917 GTP/Mg2+ binding site [chemical binding]; other site 1155084004918 Switch I region; other site 1155084004919 G2 box; other site 1155084004920 G3 box; other site 1155084004921 Switch II region; other site 1155084004922 G4 box; other site 1155084004923 G5 box; other site 1155084004924 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1155084004925 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1155084004926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084004927 Walker A motif; other site 1155084004928 ATP binding site [chemical binding]; other site 1155084004929 Walker B motif; other site 1155084004930 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155084004931 trigger factor; Provisional; Region: tig; PRK01490 1155084004932 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1155084004933 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1155084004934 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1155084004935 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1155084004936 23S rRNA binding site [nucleotide binding]; other site 1155084004937 L21 binding site [polypeptide binding]; other site 1155084004938 L13 binding site [polypeptide binding]; other site 1155084004939 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1155084004940 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1155084004941 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1155084004942 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1155084004943 lysine transporter; Provisional; Region: PRK10836 1155084004944 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1155084004945 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1155084004946 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1155084004947 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1155084004948 active site 1155084004949 dimer interface [polypeptide binding]; other site 1155084004950 motif 1; other site 1155084004951 motif 2; other site 1155084004952 motif 3; other site 1155084004953 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1155084004954 anticodon binding site; other site 1155084004955 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1155084004956 primosomal protein DnaI; Reviewed; Region: PRK08939 1155084004957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084004958 Walker A motif; other site 1155084004959 ATP binding site [chemical binding]; other site 1155084004960 Walker B motif; other site 1155084004961 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1155084004962 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1155084004963 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1155084004964 ATP cone domain; Region: ATP-cone; pfam03477 1155084004965 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1155084004966 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1155084004967 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1155084004968 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1155084004969 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1155084004970 CoA-binding site [chemical binding]; other site 1155084004971 ATP-binding [chemical binding]; other site 1155084004972 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1155084004973 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1155084004974 DNA binding site [nucleotide binding] 1155084004975 catalytic residue [active] 1155084004976 H2TH interface [polypeptide binding]; other site 1155084004977 putative catalytic residues [active] 1155084004978 turnover-facilitating residue; other site 1155084004979 intercalation triad [nucleotide binding]; other site 1155084004980 8OG recognition residue [nucleotide binding]; other site 1155084004981 putative reading head residues; other site 1155084004982 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1155084004983 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1155084004984 DNA polymerase I; Provisional; Region: PRK05755 1155084004985 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1155084004986 active site 1155084004987 metal binding site 1 [ion binding]; metal-binding site 1155084004988 putative 5' ssDNA interaction site; other site 1155084004989 metal binding site 3; metal-binding site 1155084004990 metal binding site 2 [ion binding]; metal-binding site 1155084004991 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1155084004992 putative DNA binding site [nucleotide binding]; other site 1155084004993 putative metal binding site [ion binding]; other site 1155084004994 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1155084004995 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1155084004996 active site 1155084004997 DNA binding site [nucleotide binding] 1155084004998 catalytic site [active] 1155084004999 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1155084005000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155084005001 dimer interface [polypeptide binding]; other site 1155084005002 phosphorylation site [posttranslational modification] 1155084005003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084005004 ATP binding site [chemical binding]; other site 1155084005005 Mg2+ binding site [ion binding]; other site 1155084005006 G-X-G motif; other site 1155084005007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155084005008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084005009 active site 1155084005010 phosphorylation site [posttranslational modification] 1155084005011 intermolecular recognition site; other site 1155084005012 dimerization interface [polypeptide binding]; other site 1155084005013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155084005014 DNA binding site [nucleotide binding] 1155084005015 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1155084005016 isocitrate dehydrogenase; Validated; Region: PRK07362 1155084005017 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1155084005018 dimer interface [polypeptide binding]; other site 1155084005019 Citrate synthase; Region: Citrate_synt; pfam00285 1155084005020 active site 1155084005021 citrylCoA binding site [chemical binding]; other site 1155084005022 oxalacetate/citrate binding site [chemical binding]; other site 1155084005023 coenzyme A binding site [chemical binding]; other site 1155084005024 catalytic triad [active] 1155084005025 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155084005026 pyruvate kinase; Provisional; Region: PRK06354 1155084005027 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1155084005028 domain interfaces; other site 1155084005029 active site 1155084005030 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1155084005031 6-phosphofructokinase; Provisional; Region: PRK03202 1155084005032 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1155084005033 active site 1155084005034 ADP/pyrophosphate binding site [chemical binding]; other site 1155084005035 dimerization interface [polypeptide binding]; other site 1155084005036 allosteric effector site; other site 1155084005037 fructose-1,6-bisphosphate binding site; other site 1155084005038 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1155084005039 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1155084005040 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1155084005041 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1155084005042 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1155084005043 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1155084005044 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1155084005045 putative NAD(P) binding site [chemical binding]; other site 1155084005046 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1155084005047 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1155084005048 active site 1155084005049 PHP Thumb interface [polypeptide binding]; other site 1155084005050 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1155084005051 generic binding surface I; other site 1155084005052 generic binding surface II; other site 1155084005053 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1155084005054 DHH family; Region: DHH; pfam01368 1155084005055 DHHA1 domain; Region: DHHA1; pfam02272 1155084005056 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1155084005057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1155084005058 DNA-binding site [nucleotide binding]; DNA binding site 1155084005059 DRTGG domain; Region: DRTGG; pfam07085 1155084005060 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1155084005061 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1155084005062 active site 2 [active] 1155084005063 active site 1 [active] 1155084005064 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1155084005065 Ligand Binding Site [chemical binding]; other site 1155084005066 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1155084005067 metal-dependent hydrolase; Provisional; Region: PRK00685 1155084005068 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1155084005069 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1155084005070 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1155084005071 active site 1155084005072 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1155084005073 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1155084005074 hexamer interface [polypeptide binding]; other site 1155084005075 ligand binding site [chemical binding]; other site 1155084005076 putative active site [active] 1155084005077 NAD(P) binding site [chemical binding]; other site 1155084005078 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1155084005079 Ligand Binding Site [chemical binding]; other site 1155084005080 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1155084005081 propionate/acetate kinase; Provisional; Region: PRK12379 1155084005082 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1155084005083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084005084 S-adenosylmethionine binding site [chemical binding]; other site 1155084005085 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1155084005086 dimer interface [polypeptide binding]; other site 1155084005087 catalytic triad [active] 1155084005088 peroxidatic and resolving cysteines [active] 1155084005089 hypothetical protein; Provisional; Region: PRK10621 1155084005090 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1155084005091 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1155084005092 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1155084005093 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1155084005094 Ligand Binding Site [chemical binding]; other site 1155084005095 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1155084005096 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1155084005097 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155084005098 catalytic residue [active] 1155084005099 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1155084005100 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1155084005101 GAF domain; Region: GAF_2; pfam13185 1155084005102 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1155084005103 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1155084005104 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155084005105 RNA binding surface [nucleotide binding]; other site 1155084005106 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1155084005107 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1155084005108 active site 1155084005109 catalytic site [active] 1155084005110 OsmC-like protein; Region: OsmC; cl00767 1155084005111 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1155084005112 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155084005113 catalytic residue [active] 1155084005114 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1155084005115 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1155084005116 ligand binding site [chemical binding]; other site 1155084005117 NAD binding site [chemical binding]; other site 1155084005118 dimerization interface [polypeptide binding]; other site 1155084005119 catalytic site [active] 1155084005120 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1155084005121 putative L-serine binding site [chemical binding]; other site 1155084005122 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1155084005123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084005124 motif II; other site 1155084005125 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1155084005126 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155084005127 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155084005128 active site turn [active] 1155084005129 phosphorylation site [posttranslational modification] 1155084005130 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1155084005131 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1155084005132 putative acyl-acceptor binding pocket; other site 1155084005133 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1155084005134 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1155084005135 protein binding site [polypeptide binding]; other site 1155084005136 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1155084005137 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1155084005138 active site 1155084005139 HIGH motif; other site 1155084005140 dimer interface [polypeptide binding]; other site 1155084005141 KMSKS motif; other site 1155084005142 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155084005143 RNA binding surface [nucleotide binding]; other site 1155084005144 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1155084005145 Transglycosylase; Region: Transgly; pfam00912 1155084005146 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1155084005147 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1155084005148 NEAr Transporter domain; Region: NEAT; smart00725 1155084005149 NEAr Transporter domain; Region: NEAT; smart00725 1155084005150 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1155084005151 heme-binding site [chemical binding]; other site 1155084005152 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1155084005153 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1155084005154 Potassium binding sites [ion binding]; other site 1155084005155 Cesium cation binding sites [ion binding]; other site 1155084005156 acetyl-CoA synthetase; Provisional; Region: PRK04319 1155084005157 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1155084005158 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1155084005159 active site 1155084005160 acyl-activating enzyme (AAE) consensus motif; other site 1155084005161 putative CoA binding site [chemical binding]; other site 1155084005162 AMP binding site [chemical binding]; other site 1155084005163 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1155084005164 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1155084005165 active site 1155084005166 Zn binding site [ion binding]; other site 1155084005167 catabolite control protein A; Region: ccpA; TIGR01481 1155084005168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155084005169 DNA binding site [nucleotide binding] 1155084005170 domain linker motif; other site 1155084005171 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1155084005172 dimerization interface [polypeptide binding]; other site 1155084005173 effector binding site; other site 1155084005174 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1155084005175 Chorismate mutase type II; Region: CM_2; cl00693 1155084005176 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1155084005177 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1155084005178 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1155084005179 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155084005180 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155084005181 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155084005182 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1155084005183 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1155084005184 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1155084005185 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1155084005186 putative tRNA-binding site [nucleotide binding]; other site 1155084005187 hypothetical protein; Provisional; Region: PRK13668 1155084005188 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155084005189 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1155084005190 catalytic residues [active] 1155084005191 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1155084005192 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1155084005193 oligomer interface [polypeptide binding]; other site 1155084005194 active site 1155084005195 metal binding site [ion binding]; metal-binding site 1155084005196 Predicted small secreted protein [Function unknown]; Region: COG5584 1155084005197 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1155084005198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084005199 S-adenosylmethionine binding site [chemical binding]; other site 1155084005200 Phosphotransferase enzyme family; Region: APH; pfam01636 1155084005201 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1155084005202 active site 1155084005203 substrate binding site [chemical binding]; other site 1155084005204 ATP binding site [chemical binding]; other site 1155084005205 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1155084005206 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1155084005207 homodimer interface [polypeptide binding]; other site 1155084005208 substrate-cofactor binding pocket; other site 1155084005209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084005210 catalytic residue [active] 1155084005211 dipeptidase PepV; Reviewed; Region: PRK07318 1155084005212 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1155084005213 active site 1155084005214 metal binding site [ion binding]; metal-binding site 1155084005215 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1155084005216 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1155084005217 RNA binding surface [nucleotide binding]; other site 1155084005218 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1155084005219 active site 1155084005220 uracil binding [chemical binding]; other site 1155084005221 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1155084005222 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1155084005223 HI0933-like protein; Region: HI0933_like; pfam03486 1155084005224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155084005225 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084005226 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1155084005227 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005228 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005229 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005230 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005231 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005232 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005233 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005234 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005235 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005236 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005237 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005238 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005239 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005240 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084005241 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1155084005242 active site residue [active] 1155084005243 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1155084005244 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1155084005245 HIGH motif; other site 1155084005246 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1155084005247 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1155084005248 active site 1155084005249 KMSKS motif; other site 1155084005250 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1155084005251 tRNA binding surface [nucleotide binding]; other site 1155084005252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084005253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084005254 putative substrate translocation pore; other site 1155084005255 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1155084005256 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1155084005257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084005258 S-adenosylmethionine binding site [chemical binding]; other site 1155084005259 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1155084005260 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1155084005261 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1155084005262 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1155084005263 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1155084005264 homopentamer interface [polypeptide binding]; other site 1155084005265 active site 1155084005266 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1155084005267 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1155084005268 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1155084005269 dimerization interface [polypeptide binding]; other site 1155084005270 active site 1155084005271 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1155084005272 Lumazine binding domain; Region: Lum_binding; pfam00677 1155084005273 Lumazine binding domain; Region: Lum_binding; pfam00677 1155084005274 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1155084005275 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1155084005276 catalytic motif [active] 1155084005277 Zn binding site [ion binding]; other site 1155084005278 RibD C-terminal domain; Region: RibD_C; cl17279 1155084005279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1155084005280 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1155084005281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155084005282 dimerization interface [polypeptide binding]; other site 1155084005283 putative DNA binding site [nucleotide binding]; other site 1155084005284 putative Zn2+ binding site [ion binding]; other site 1155084005285 arsenical pump membrane protein; Provisional; Region: PRK15445 1155084005286 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1155084005287 transmembrane helices; other site 1155084005288 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1155084005289 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1155084005290 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1155084005291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1155084005292 DNA binding residues [nucleotide binding] 1155084005293 CAAX protease self-immunity; Region: Abi; pfam02517 1155084005294 CAAX protease self-immunity; Region: Abi; pfam02517 1155084005295 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1155084005296 active site 1155084005297 intersubunit interactions; other site 1155084005298 catalytic residue [active] 1155084005299 camphor resistance protein CrcB; Provisional; Region: PRK14201 1155084005300 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1155084005301 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155084005302 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155084005303 active site 1155084005304 catalytic tetrad [active] 1155084005305 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1155084005306 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1155084005307 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1155084005308 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1155084005309 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1155084005310 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1155084005311 active site 1155084005312 substrate-binding site [chemical binding]; other site 1155084005313 metal-binding site [ion binding] 1155084005314 ATP binding site [chemical binding]; other site 1155084005315 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1155084005316 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1155084005317 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1155084005318 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1155084005319 nudix motif; other site 1155084005320 Haemolytic domain; Region: Haemolytic; pfam01809 1155084005321 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1155084005322 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1155084005323 metal binding site [ion binding]; metal-binding site 1155084005324 substrate binding pocket [chemical binding]; other site 1155084005325 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1155084005326 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1155084005327 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1155084005328 acyl-activating enzyme (AAE) consensus motif; other site 1155084005329 putative AMP binding site [chemical binding]; other site 1155084005330 putative active site [active] 1155084005331 putative CoA binding site [chemical binding]; other site 1155084005332 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1155084005333 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1155084005334 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1155084005335 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1155084005336 HTH-like domain; Region: HTH_21; pfam13276 1155084005337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155084005338 Transposase; Region: HTH_Tnp_1; pfam01527 1155084005339 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084005340 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084005341 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084005342 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1155084005343 substrate binding site [chemical binding]; other site 1155084005344 catalytic residues [active] 1155084005345 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084005346 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084005347 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1155084005348 transposase/IS protein; Provisional; Region: PRK09183 1155084005349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084005350 Walker A motif; other site 1155084005351 ATP binding site [chemical binding]; other site 1155084005352 Walker B motif; other site 1155084005353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1155084005354 Integrase core domain; Region: rve; pfam00665 1155084005355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1155084005356 Integrase core domain; Region: rve; pfam00665 1155084005357 Replication protein; Region: Rep_1; cl02412 1155084005358 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155084005359 putative DNA binding site [nucleotide binding]; other site 1155084005360 putative Zn2+ binding site [ion binding]; other site 1155084005361 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1155084005362 Cadmium resistance transporter; Region: Cad; pfam03596 1155084005363 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1155084005364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084005365 S-adenosylmethionine binding site [chemical binding]; other site 1155084005366 Replication protein; Region: Rep_1; cl02412 1155084005367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1155084005368 Integrase core domain; Region: rve; pfam00665 1155084005369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1155084005370 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1155084005371 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1155084005372 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1155084005373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155084005374 ferrochelatase; Provisional; Region: PRK12435 1155084005375 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1155084005376 C-terminal domain interface [polypeptide binding]; other site 1155084005377 active site 1155084005378 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1155084005379 active site 1155084005380 N-terminal domain interface [polypeptide binding]; other site 1155084005381 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1155084005382 substrate binding site [chemical binding]; other site 1155084005383 active site 1155084005384 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1155084005385 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1155084005386 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1155084005387 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155084005388 Walker A/P-loop; other site 1155084005389 ATP binding site [chemical binding]; other site 1155084005390 Q-loop/lid; other site 1155084005391 ABC transporter signature motif; other site 1155084005392 Walker B; other site 1155084005393 D-loop; other site 1155084005394 H-loop/switch region; other site 1155084005395 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1155084005396 HIT family signature motif; other site 1155084005397 catalytic residue [active] 1155084005398 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1155084005399 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1155084005400 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1155084005401 SurA N-terminal domain; Region: SurA_N_3; cl07813 1155084005402 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1155084005403 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1155084005404 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1155084005405 generic binding surface II; other site 1155084005406 generic binding surface I; other site 1155084005407 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155084005408 Zn2+ binding site [ion binding]; other site 1155084005409 Mg2+ binding site [ion binding]; other site 1155084005410 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1155084005411 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1155084005412 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1155084005413 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1155084005414 active site 1155084005415 metal binding site [ion binding]; metal-binding site 1155084005416 DNA binding site [nucleotide binding] 1155084005417 hypothetical protein; Provisional; Region: PRK13676 1155084005418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1155084005419 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155084005420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084005421 non-specific DNA binding site [nucleotide binding]; other site 1155084005422 salt bridge; other site 1155084005423 sequence-specific DNA binding site [nucleotide binding]; other site 1155084005424 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155084005425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084005426 active site 1155084005427 phosphorylation site [posttranslational modification] 1155084005428 intermolecular recognition site; other site 1155084005429 dimerization interface [polypeptide binding]; other site 1155084005430 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155084005431 DNA binding residues [nucleotide binding] 1155084005432 dimerization interface [polypeptide binding]; other site 1155084005433 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1155084005434 GAF domain; Region: GAF_3; pfam13492 1155084005435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155084005436 Histidine kinase; Region: HisKA_3; pfam07730 1155084005437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084005438 ATP binding site [chemical binding]; other site 1155084005439 Mg2+ binding site [ion binding]; other site 1155084005440 G-X-G motif; other site 1155084005441 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1155084005442 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1155084005443 active site 1155084005444 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1155084005445 Class II fumarases; Region: Fumarase_classII; cd01362 1155084005446 active site 1155084005447 tetramer interface [polypeptide binding]; other site 1155084005448 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1155084005449 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1155084005450 active site 1155084005451 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1155084005452 epoxyqueuosine reductase; Region: TIGR00276 1155084005453 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1155084005454 HEAT repeats; Region: HEAT_2; pfam13646 1155084005455 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155084005456 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155084005457 Walker A/P-loop; other site 1155084005458 ATP binding site [chemical binding]; other site 1155084005459 Q-loop/lid; other site 1155084005460 ABC transporter signature motif; other site 1155084005461 Walker B; other site 1155084005462 D-loop; other site 1155084005463 H-loop/switch region; other site 1155084005464 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155084005465 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155084005466 substrate binding pocket [chemical binding]; other site 1155084005467 membrane-bound complex binding site; other site 1155084005468 hinge residues; other site 1155084005469 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155084005470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084005471 dimer interface [polypeptide binding]; other site 1155084005472 conserved gate region; other site 1155084005473 putative PBP binding loops; other site 1155084005474 ABC-ATPase subunit interface; other site 1155084005475 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1155084005476 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1155084005477 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1155084005478 metal binding site 2 [ion binding]; metal-binding site 1155084005479 putative DNA binding helix; other site 1155084005480 metal binding site 1 [ion binding]; metal-binding site 1155084005481 dimer interface [polypeptide binding]; other site 1155084005482 structural Zn2+ binding site [ion binding]; other site 1155084005483 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1155084005484 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1155084005485 putative ligand binding site [chemical binding]; other site 1155084005486 NAD binding site [chemical binding]; other site 1155084005487 catalytic site [active] 1155084005488 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1155084005489 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1155084005490 catalytic triad [active] 1155084005491 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1155084005492 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155084005493 inhibitor-cofactor binding pocket; inhibition site 1155084005494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084005495 catalytic residue [active] 1155084005496 Predicted membrane protein [Function unknown]; Region: COG4129 1155084005497 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1155084005498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155084005499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155084005500 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1155084005501 Walker A/P-loop; other site 1155084005502 ATP binding site [chemical binding]; other site 1155084005503 Q-loop/lid; other site 1155084005504 ABC transporter signature motif; other site 1155084005505 Walker B; other site 1155084005506 D-loop; other site 1155084005507 H-loop/switch region; other site 1155084005508 hypothetical protein; Provisional; Region: PRK13662 1155084005509 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1155084005510 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1155084005511 minor groove reading motif; other site 1155084005512 helix-hairpin-helix signature motif; other site 1155084005513 substrate binding pocket [chemical binding]; other site 1155084005514 active site 1155084005515 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1155084005516 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1155084005517 DNA binding and oxoG recognition site [nucleotide binding] 1155084005518 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1155084005519 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1155084005520 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1155084005521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084005522 Walker A/P-loop; other site 1155084005523 ATP binding site [chemical binding]; other site 1155084005524 Q-loop/lid; other site 1155084005525 ABC transporter signature motif; other site 1155084005526 Walker B; other site 1155084005527 H-loop/switch region; other site 1155084005528 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1155084005529 recombination regulator RecX; Provisional; Region: recX; PRK14135 1155084005530 glycosyltransferase; Provisional; Region: PRK13481 1155084005531 Transglycosylase; Region: Transgly; pfam00912 1155084005532 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1155084005533 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1155084005534 proposed catalytic triad [active] 1155084005535 conserved cys residue [active] 1155084005536 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1155084005537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084005538 FeS/SAM binding site; other site 1155084005539 YfkB-like domain; Region: YfkB; pfam08756 1155084005540 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1155084005541 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1155084005542 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1155084005543 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1155084005544 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1155084005545 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1155084005546 active site 1155084005547 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1155084005548 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155084005549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084005550 active site 1155084005551 phosphorylation site [posttranslational modification] 1155084005552 intermolecular recognition site; other site 1155084005553 dimerization interface [polypeptide binding]; other site 1155084005554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155084005555 DNA binding residues [nucleotide binding] 1155084005556 dimerization interface [polypeptide binding]; other site 1155084005557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155084005558 Histidine kinase; Region: HisKA_3; pfam07730 1155084005559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084005560 ATP binding site [chemical binding]; other site 1155084005561 Mg2+ binding site [ion binding]; other site 1155084005562 G-X-G motif; other site 1155084005563 Predicted membrane protein [Function unknown]; Region: COG4758 1155084005564 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1155084005565 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1155084005566 active site 1155084005567 Predicted membrane protein [Function unknown]; Region: COG4129 1155084005568 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1155084005569 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1155084005570 catalytic triad [active] 1155084005571 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1155084005572 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155084005573 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1155084005574 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1155084005575 Ferritin-like domain; Region: Ferritin; pfam00210 1155084005576 ferroxidase diiron center [ion binding]; other site 1155084005577 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1155084005578 active site 1155084005579 catalytic site [active] 1155084005580 substrate binding site [chemical binding]; other site 1155084005581 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1155084005582 active site 1155084005583 DNA polymerase IV; Validated; Region: PRK02406 1155084005584 DNA binding site [nucleotide binding] 1155084005585 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1155084005586 TRAM domain; Region: TRAM; cl01282 1155084005587 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1155084005588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084005589 S-adenosylmethionine binding site [chemical binding]; other site 1155084005590 putative lipid kinase; Reviewed; Region: PRK13337 1155084005591 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1155084005592 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1155084005593 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1155084005594 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1155084005595 GatB domain; Region: GatB_Yqey; pfam02637 1155084005596 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1155084005597 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1155084005598 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1155084005599 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1155084005600 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1155084005601 Na binding site [ion binding]; other site 1155084005602 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1155084005603 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1155084005604 putative dimer interface [polypeptide binding]; other site 1155084005605 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1155084005606 putative dimer interface [polypeptide binding]; other site 1155084005607 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1155084005608 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1155084005609 nucleotide binding pocket [chemical binding]; other site 1155084005610 K-X-D-G motif; other site 1155084005611 catalytic site [active] 1155084005612 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1155084005613 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1155084005614 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1155084005615 Dimer interface [polypeptide binding]; other site 1155084005616 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1155084005617 Part of AAA domain; Region: AAA_19; pfam13245 1155084005618 Family description; Region: UvrD_C_2; pfam13538 1155084005619 PcrB family; Region: PcrB; pfam01884 1155084005620 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1155084005621 substrate binding site [chemical binding]; other site 1155084005622 putative active site [active] 1155084005623 dimer interface [polypeptide binding]; other site 1155084005624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1155084005625 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1155084005626 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1155084005627 tetramer interface [polypeptide binding]; other site 1155084005628 active site 1155084005629 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1155084005630 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1155084005631 Staphostatin A; Region: Staphostatin_A; pfam09022 1155084005632 NETI protein; Region: NETI; pfam14044 1155084005633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1155084005634 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1155084005635 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1155084005636 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1155084005637 homodimer interface [polypeptide binding]; other site 1155084005638 NAD binding pocket [chemical binding]; other site 1155084005639 ATP binding pocket [chemical binding]; other site 1155084005640 Mg binding site [ion binding]; other site 1155084005641 active-site loop [active] 1155084005642 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1155084005643 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1155084005644 active site 1155084005645 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1155084005646 active site 1155084005647 dimer interface [polypeptide binding]; other site 1155084005648 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1155084005649 Prephenate dehydratase; Region: PDT; pfam00800 1155084005650 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1155084005651 putative L-Phe binding site [chemical binding]; other site 1155084005652 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1155084005653 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1155084005654 transmembrane helices; other site 1155084005655 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1155084005656 Isochorismatase family; Region: Isochorismatase; pfam00857 1155084005657 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155084005658 catalytic triad [active] 1155084005659 conserved cis-peptide bond; other site 1155084005660 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1155084005661 DHH family; Region: DHH; pfam01368 1155084005662 DHHA2 domain; Region: DHHA2; pfam02833 1155084005663 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1155084005664 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1155084005665 NAD(P) binding site [chemical binding]; other site 1155084005666 catalytic residues [active] 1155084005667 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1155084005668 Predicted transcriptional regulator [Transcription]; Region: COG3682 1155084005669 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1155084005670 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1155084005671 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1155084005672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1155084005673 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155084005674 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1155084005675 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1155084005676 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1155084005677 NAD binding site [chemical binding]; other site 1155084005678 homotetramer interface [polypeptide binding]; other site 1155084005679 homodimer interface [polypeptide binding]; other site 1155084005680 substrate binding site [chemical binding]; other site 1155084005681 active site 1155084005682 YolD-like protein; Region: YolD; pfam08863 1155084005683 Tn544B and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes various bacterial transposases similar to TnpB from transposon Tn554; Region: INT_Tn544B_C; cd01195 1155084005684 Int/Topo IB signature motif; other site 1155084005685 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1155084005686 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1155084005687 Tn544A and related transposases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal catalytic domain. This CD includes various bacterial transposases similar to TnpA from transposon Tn554; Region: INT_Tn554A_C; cd01194 1155084005688 Int/Topo IB signature motif; other site 1155084005689 YolD-like protein; Region: YolD; pfam08863 1155084005690 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1155084005691 active site 1155084005692 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1155084005693 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1155084005694 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1155084005695 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1155084005696 Bacterial PH domain; Region: DUF304; cl01348 1155084005697 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 1155084005698 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155084005699 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155084005700 Walker A/P-loop; other site 1155084005701 ATP binding site [chemical binding]; other site 1155084005702 Q-loop/lid; other site 1155084005703 ABC transporter signature motif; other site 1155084005704 Walker B; other site 1155084005705 D-loop; other site 1155084005706 H-loop/switch region; other site 1155084005707 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1155084005708 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1155084005709 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1155084005710 Walker A/P-loop; other site 1155084005711 ATP binding site [chemical binding]; other site 1155084005712 Q-loop/lid; other site 1155084005713 ABC transporter signature motif; other site 1155084005714 Walker B; other site 1155084005715 D-loop; other site 1155084005716 H-loop/switch region; other site 1155084005717 Predicted transcriptional regulators [Transcription]; Region: COG1725 1155084005718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155084005719 DNA-binding site [nucleotide binding]; DNA binding site 1155084005720 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1155084005721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155084005722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084005723 homodimer interface [polypeptide binding]; other site 1155084005724 catalytic residue [active] 1155084005725 MAP domain; Region: MAP; pfam03642 1155084005726 MAP domain; Region: MAP; pfam03642 1155084005727 MAP domain; Region: MAP; pfam03642 1155084005728 MAP domain; Region: MAP; pfam03642 1155084005729 MAP domain; Region: MAP; pfam03642 1155084005730 MAP domain; Region: MAP; pfam03642 1155084005731 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1155084005732 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1155084005733 chemotaxis-inhibiting protein CHIPS; Reviewed; Region: PRK13032 1155084005734 CHAP domain; Region: CHAP; pfam05257 1155084005735 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1155084005736 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1155084005737 active site 1155084005738 metal binding site [ion binding]; metal-binding site 1155084005739 Bacterial SH3 domain; Region: SH3_5; pfam08460 1155084005740 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1155084005741 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1155084005742 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 1155084005743 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 1155084005744 Phage tail protein; Region: Sipho_tail; cl17486 1155084005745 Phage tail protein; Region: Sipho_tail; cl17486 1155084005746 Phage-related minor tail protein [Function unknown]; Region: COG5280 1155084005747 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1155084005748 Phage-related protein [Function unknown]; Region: COG5412 1155084005749 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155084005750 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155084005751 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155084005752 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155084005753 catalytic residue [active] 1155084005754 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1155084005755 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1155084005756 Translocation protein Sec62; Region: Sec62; cl02170 1155084005757 Phage capsid family; Region: Phage_capsid; pfam05065 1155084005758 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1155084005759 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1155084005760 oligomer interface [polypeptide binding]; other site 1155084005761 active site residues [active] 1155084005762 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1155084005763 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1155084005764 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1155084005765 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1155084005766 HNH endonuclease; Region: HNH; pfam01844 1155084005767 active site 1155084005768 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1155084005769 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1155084005770 Transcriptional activator RinB; Region: RinB; pfam06116 1155084005771 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1155084005772 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1155084005773 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1155084005774 trimer interface [polypeptide binding]; other site 1155084005775 active site 1155084005776 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1155084005777 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1155084005778 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1155084005779 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1155084005780 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1155084005781 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1155084005782 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1155084005783 dimer interface [polypeptide binding]; other site 1155084005784 ssDNA binding site [nucleotide binding]; other site 1155084005785 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155084005786 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1155084005787 RecT family; Region: RecT; pfam03837 1155084005788 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1155084005789 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1155084005790 Hypothetical protein of unknown function (DUF2482); Region: DUF2482; pfam10655 1155084005791 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 1155084005792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 1155084005793 Phage anti-repressor protein [Transcription]; Region: COG3561 1155084005794 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 1155084005795 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1155084005796 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155084005797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084005798 non-specific DNA binding site [nucleotide binding]; other site 1155084005799 salt bridge; other site 1155084005800 sequence-specific DNA binding site [nucleotide binding]; other site 1155084005801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084005802 non-specific DNA binding site [nucleotide binding]; other site 1155084005803 salt bridge; other site 1155084005804 sequence-specific DNA binding site [nucleotide binding]; other site 1155084005805 Predicted transcriptional regulator [Transcription]; Region: COG2932 1155084005806 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1155084005807 Catalytic site [active] 1155084005808 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1155084005809 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1155084005810 active site 1155084005811 catalytic site [active] 1155084005812 substrate binding site [chemical binding]; other site 1155084005813 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1155084005814 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1155084005815 Int/Topo IB signature motif; other site 1155084005816 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1155084005817 putative catalytic site [active] 1155084005818 phosphate binding site [ion binding]; other site 1155084005819 metal binding site A [ion binding]; metal-binding site 1155084005820 metal binding site C [ion binding]; metal-binding site 1155084005821 metal binding site B [ion binding]; metal-binding site 1155084005822 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1155084005823 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1155084005824 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1155084005825 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1155084005826 metal binding site [ion binding]; metal-binding site 1155084005827 dimer interface [polypeptide binding]; other site 1155084005828 Cation transport protein; Region: TrkH; cl17365 1155084005829 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1155084005830 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1155084005831 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1155084005832 ring oligomerisation interface [polypeptide binding]; other site 1155084005833 ATP/Mg binding site [chemical binding]; other site 1155084005834 stacking interactions; other site 1155084005835 hinge regions; other site 1155084005836 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1155084005837 oligomerisation interface [polypeptide binding]; other site 1155084005838 mobile loop; other site 1155084005839 roof hairpin; other site 1155084005840 CAAX protease self-immunity; Region: Abi; pfam02517 1155084005841 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1155084005842 dimer interface [polypeptide binding]; other site 1155084005843 FMN binding site [chemical binding]; other site 1155084005844 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1155084005845 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1155084005846 putative active site [active] 1155084005847 catalytic triad [active] 1155084005848 putative dimer interface [polypeptide binding]; other site 1155084005849 delta-hemolysin; Provisional; Region: PRK14752 1155084005850 Accessory gene regulator B; Region: AgrB; smart00793 1155084005851 Staphylococcal AgrD protein; Region: AgrD; smart00794 1155084005852 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1155084005853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084005854 Mg2+ binding site [ion binding]; other site 1155084005855 G-X-G motif; other site 1155084005856 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1155084005857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084005858 active site 1155084005859 phosphorylation site [posttranslational modification] 1155084005860 intermolecular recognition site; other site 1155084005861 dimerization interface [polypeptide binding]; other site 1155084005862 LytTr DNA-binding domain; Region: LytTR; pfam04397 1155084005863 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1155084005864 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1155084005865 putative substrate binding site [chemical binding]; other site 1155084005866 putative ATP binding site [chemical binding]; other site 1155084005867 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1155084005868 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1155084005869 substrate binding [chemical binding]; other site 1155084005870 active site 1155084005871 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1155084005872 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1155084005873 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1155084005874 DNA binding site [nucleotide binding] 1155084005875 domain linker motif; other site 1155084005876 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1155084005877 dimerization interface [polypeptide binding]; other site 1155084005878 ligand binding site [chemical binding]; other site 1155084005879 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1155084005880 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1155084005881 CPxP motif; other site 1155084005882 Predicted transporter component [General function prediction only]; Region: COG2391 1155084005883 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1155084005884 Sulphur transport; Region: Sulf_transp; pfam04143 1155084005885 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1155084005886 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1155084005887 CoA binding domain; Region: CoA_binding; pfam02629 1155084005888 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1155084005889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155084005890 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155084005891 ABC transporter; Region: ABC_tran_2; pfam12848 1155084005892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1155084005893 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1155084005894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084005895 Walker A/P-loop; other site 1155084005896 ATP binding site [chemical binding]; other site 1155084005897 Q-loop/lid; other site 1155084005898 ABC transporter signature motif; other site 1155084005899 Walker B; other site 1155084005900 D-loop; other site 1155084005901 H-loop/switch region; other site 1155084005902 UGMP family protein; Validated; Region: PRK09604 1155084005903 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1155084005904 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1155084005905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084005906 Coenzyme A binding pocket [chemical binding]; other site 1155084005907 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1155084005908 Glycoprotease family; Region: Peptidase_M22; pfam00814 1155084005909 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1155084005910 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1155084005911 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1155084005912 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1155084005913 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1155084005914 PYR/PP interface [polypeptide binding]; other site 1155084005915 dimer interface [polypeptide binding]; other site 1155084005916 TPP binding site [chemical binding]; other site 1155084005917 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155084005918 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1155084005919 TPP-binding site [chemical binding]; other site 1155084005920 dimer interface [polypeptide binding]; other site 1155084005921 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 1155084005922 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1155084005923 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1155084005924 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1155084005925 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1155084005926 2-isopropylmalate synthase; Validated; Region: PRK00915 1155084005927 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1155084005928 active site 1155084005929 catalytic residues [active] 1155084005930 metal binding site [ion binding]; metal-binding site 1155084005931 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1155084005932 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1155084005933 tartrate dehydrogenase; Region: TTC; TIGR02089 1155084005934 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1155084005935 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1155084005936 substrate binding site [chemical binding]; other site 1155084005937 ligand binding site [chemical binding]; other site 1155084005938 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1155084005939 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1155084005940 substrate binding site [chemical binding]; other site 1155084005941 threonine dehydratase; Validated; Region: PRK08639 1155084005942 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1155084005943 tetramer interface [polypeptide binding]; other site 1155084005944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084005945 catalytic residue [active] 1155084005946 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1155084005947 putative Ile/Val binding site [chemical binding]; other site 1155084005948 hypothetical protein; Provisional; Region: PRK04351 1155084005949 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1155084005950 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1155084005951 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1155084005952 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1155084005953 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1155084005954 RNA binding site [nucleotide binding]; other site 1155084005955 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1155084005956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1155084005957 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1155084005958 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1155084005959 DNA binding residues [nucleotide binding] 1155084005960 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1155084005961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084005962 ATP binding site [chemical binding]; other site 1155084005963 Mg2+ binding site [ion binding]; other site 1155084005964 G-X-G motif; other site 1155084005965 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1155084005966 anti sigma factor interaction site; other site 1155084005967 regulatory phosphorylation site [posttranslational modification]; other site 1155084005968 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1155084005969 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1155084005970 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1155084005971 PemK-like protein; Region: PemK; pfam02452 1155084005972 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1155084005973 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1155084005974 active site 1155084005975 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155084005976 dimer interface [polypeptide binding]; other site 1155084005977 substrate binding site [chemical binding]; other site 1155084005978 catalytic residues [active] 1155084005979 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1155084005980 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1155084005981 Predicted membrane protein [Function unknown]; Region: COG3428 1155084005982 Bacterial PH domain; Region: DUF304; pfam03703 1155084005983 Bacterial PH domain; Region: DUF304; pfam03703 1155084005984 Bacterial PH domain; Region: DUF304; cl01348 1155084005985 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 1155084005986 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1155084005987 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155084005988 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155084005989 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1155084005990 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1155084005991 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1155084005992 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1155084005993 Ligand Binding Site [chemical binding]; other site 1155084005994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155084005995 dimer interface [polypeptide binding]; other site 1155084005996 phosphorylation site [posttranslational modification] 1155084005997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084005998 ATP binding site [chemical binding]; other site 1155084005999 Mg2+ binding site [ion binding]; other site 1155084006000 G-X-G motif; other site 1155084006001 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155084006002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084006003 active site 1155084006004 phosphorylation site [posttranslational modification] 1155084006005 intermolecular recognition site; other site 1155084006006 dimerization interface [polypeptide binding]; other site 1155084006007 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155084006008 DNA binding site [nucleotide binding] 1155084006009 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1155084006010 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1155084006011 ATP binding site [chemical binding]; other site 1155084006012 Mg++ binding site [ion binding]; other site 1155084006013 motif III; other site 1155084006014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1155084006015 nucleotide binding region [chemical binding]; other site 1155084006016 ATP-binding site [chemical binding]; other site 1155084006017 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1155084006018 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1155084006019 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1155084006020 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1155084006021 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1155084006022 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1155084006023 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1155084006024 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1155084006025 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1155084006026 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1155084006027 putative homodimer interface [polypeptide binding]; other site 1155084006028 putative homotetramer interface [polypeptide binding]; other site 1155084006029 allosteric switch controlling residues; other site 1155084006030 putative metal binding site [ion binding]; other site 1155084006031 putative homodimer-homodimer interface [polypeptide binding]; other site 1155084006032 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1155084006033 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1155084006034 putative active site [active] 1155084006035 catalytic site [active] 1155084006036 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1155084006037 putative active site [active] 1155084006038 catalytic site [active] 1155084006039 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1155084006040 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1155084006041 Zn2+ binding site [ion binding]; other site 1155084006042 Mg2+ binding site [ion binding]; other site 1155084006043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155084006044 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155084006045 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1155084006046 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1155084006047 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1155084006048 thiamine phosphate binding site [chemical binding]; other site 1155084006049 active site 1155084006050 pyrophosphate binding site [ion binding]; other site 1155084006051 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1155084006052 substrate binding site [chemical binding]; other site 1155084006053 multimerization interface [polypeptide binding]; other site 1155084006054 ATP binding site [chemical binding]; other site 1155084006055 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1155084006056 dimer interface [polypeptide binding]; other site 1155084006057 substrate binding site [chemical binding]; other site 1155084006058 ATP binding site [chemical binding]; other site 1155084006059 thiaminase II; Region: salvage_TenA; TIGR04306 1155084006060 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1155084006061 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1155084006062 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1155084006063 dimer interface [polypeptide binding]; other site 1155084006064 ssDNA binding site [nucleotide binding]; other site 1155084006065 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155084006066 YwpF-like protein; Region: YwpF; pfam14183 1155084006067 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1155084006068 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1155084006069 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1155084006070 hinge; other site 1155084006071 active site 1155084006072 Predicted membrane protein [Function unknown]; Region: COG4836 1155084006073 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 1155084006074 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1155084006075 gamma subunit interface [polypeptide binding]; other site 1155084006076 epsilon subunit interface [polypeptide binding]; other site 1155084006077 LBP interface [polypeptide binding]; other site 1155084006078 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1155084006079 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155084006080 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1155084006081 alpha subunit interaction interface [polypeptide binding]; other site 1155084006082 Walker A motif; other site 1155084006083 ATP binding site [chemical binding]; other site 1155084006084 Walker B motif; other site 1155084006085 inhibitor binding site; inhibition site 1155084006086 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155084006087 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1155084006088 core domain interface [polypeptide binding]; other site 1155084006089 delta subunit interface [polypeptide binding]; other site 1155084006090 epsilon subunit interface [polypeptide binding]; other site 1155084006091 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1155084006092 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1155084006093 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1155084006094 beta subunit interaction interface [polypeptide binding]; other site 1155084006095 Walker A motif; other site 1155084006096 ATP binding site [chemical binding]; other site 1155084006097 Walker B motif; other site 1155084006098 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1155084006099 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1155084006100 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1155084006101 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1155084006102 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1155084006103 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1155084006104 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1155084006105 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1155084006106 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1155084006107 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1155084006108 active site 1155084006109 homodimer interface [polypeptide binding]; other site 1155084006110 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1155084006111 active site 1155084006112 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1155084006113 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1155084006114 dimer interface [polypeptide binding]; other site 1155084006115 active site 1155084006116 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1155084006117 folate binding site [chemical binding]; other site 1155084006118 hypothetical protein; Provisional; Region: PRK13690 1155084006119 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1155084006120 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1155084006121 active site 1155084006122 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1155084006123 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1155084006124 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1155084006125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084006126 S-adenosylmethionine binding site [chemical binding]; other site 1155084006127 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1155084006128 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1155084006129 RF-1 domain; Region: RF-1; pfam00472 1155084006130 thymidine kinase; Provisional; Region: PRK04296 1155084006131 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1155084006132 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1155084006133 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1155084006134 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1155084006135 RNA binding site [nucleotide binding]; other site 1155084006136 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1155084006137 multimer interface [polypeptide binding]; other site 1155084006138 Walker A motif; other site 1155084006139 ATP binding site [chemical binding]; other site 1155084006140 Walker B motif; other site 1155084006141 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1155084006142 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1155084006143 NAD binding site [chemical binding]; other site 1155084006144 catalytic residues [active] 1155084006145 Predicted transcriptional regulators [Transcription]; Region: COG1733 1155084006146 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1155084006147 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1155084006148 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1155084006149 hinge; other site 1155084006150 active site 1155084006151 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1155084006152 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1155084006153 intersubunit interface [polypeptide binding]; other site 1155084006154 active site 1155084006155 zinc binding site [ion binding]; other site 1155084006156 Na+ binding site [ion binding]; other site 1155084006157 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1155084006158 CTP synthetase; Validated; Region: pyrG; PRK05380 1155084006159 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1155084006160 Catalytic site [active] 1155084006161 active site 1155084006162 UTP binding site [chemical binding]; other site 1155084006163 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1155084006164 active site 1155084006165 putative oxyanion hole; other site 1155084006166 catalytic triad [active] 1155084006167 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1155084006168 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1155084006169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084006170 Coenzyme A binding pocket [chemical binding]; other site 1155084006171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155084006172 Coenzyme A binding pocket [chemical binding]; other site 1155084006173 pantothenate kinase; Provisional; Region: PRK13317 1155084006174 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1155084006175 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1155084006176 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1155084006177 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1155084006178 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1155084006179 metal binding site [ion binding]; metal-binding site 1155084006180 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1155084006181 Predicted membrane protein [Function unknown]; Region: COG4270 1155084006182 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1155084006183 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1155084006184 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1155084006185 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1155084006186 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1155084006187 intersubunit interface [polypeptide binding]; other site 1155084006188 active site 1155084006189 catalytic residue [active] 1155084006190 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1155084006191 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1155084006192 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1155084006193 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1155084006194 dimerization interface [polypeptide binding]; other site 1155084006195 DPS ferroxidase diiron center [ion binding]; other site 1155084006196 ion pore; other site 1155084006197 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1155084006198 EVE domain; Region: EVE; cl00728 1155084006199 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1155084006200 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1155084006201 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1155084006202 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1155084006203 NAD(P) binding site [chemical binding]; other site 1155084006204 putative active site [active] 1155084006205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155084006206 dimerization interface [polypeptide binding]; other site 1155084006207 putative DNA binding site [nucleotide binding]; other site 1155084006208 putative Zn2+ binding site [ion binding]; other site 1155084006209 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1155084006210 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155084006211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1155084006212 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1155084006213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084006214 active site 1155084006215 motif I; other site 1155084006216 motif II; other site 1155084006217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084006218 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1155084006219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084006220 Walker A/P-loop; other site 1155084006221 ATP binding site [chemical binding]; other site 1155084006222 Q-loop/lid; other site 1155084006223 ABC transporter signature motif; other site 1155084006224 Walker B; other site 1155084006225 D-loop; other site 1155084006226 H-loop/switch region; other site 1155084006227 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 1155084006228 TIR domain; Region: TIR_2; pfam13676 1155084006229 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1155084006230 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1155084006231 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155084006232 potential frameshift: common BLAST hit: gi|379796482|ref|YP_005326483.1| transposase (pseudogene) 1155084006233 AAA domain; Region: AAA_22; pfam13401 1155084006234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1155084006235 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1155084006236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1155084006237 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155084006238 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1155084006239 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1155084006240 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1155084006241 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1155084006242 glutaminase active site [active] 1155084006243 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1155084006244 dimer interface [polypeptide binding]; other site 1155084006245 active site 1155084006246 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1155084006247 dimer interface [polypeptide binding]; other site 1155084006248 active site 1155084006249 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1155084006250 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1155084006251 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1155084006252 active site 1155084006253 P-loop; other site 1155084006254 phosphorylation site [posttranslational modification] 1155084006255 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155084006256 HTH domain; Region: HTH_11; pfam08279 1155084006257 Mga helix-turn-helix domain; Region: Mga; pfam05043 1155084006258 PRD domain; Region: PRD; pfam00874 1155084006259 PRD domain; Region: PRD; pfam00874 1155084006260 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155084006261 active site 1155084006262 P-loop; other site 1155084006263 phosphorylation site [posttranslational modification] 1155084006264 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1155084006265 active site 1155084006266 phosphorylation site [posttranslational modification] 1155084006267 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155084006268 active site 1155084006269 phosphorylation site [posttranslational modification] 1155084006270 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1155084006271 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1155084006272 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084006273 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1155084006274 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084006275 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084006276 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084006277 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084006278 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084006279 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084006280 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1155084006281 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1155084006282 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1155084006283 active site 1155084006284 substrate binding site [chemical binding]; other site 1155084006285 metal binding site [ion binding]; metal-binding site 1155084006286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1155084006287 YbbR-like protein; Region: YbbR; pfam07949 1155084006288 TIGR00159 family protein; Region: TIGR00159 1155084006289 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1155084006290 Arginase family; Region: Arginase; cd09989 1155084006291 agmatinase; Region: agmatinase; TIGR01230 1155084006292 active site 1155084006293 Mn binding site [ion binding]; other site 1155084006294 oligomer interface [polypeptide binding]; other site 1155084006295 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155084006296 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1155084006297 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1155084006298 Walker A motif; other site 1155084006299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084006300 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1155084006301 putative substrate translocation pore; other site 1155084006302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084006303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084006304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1155084006305 putative substrate translocation pore; other site 1155084006306 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1155084006307 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1155084006308 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1155084006309 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1155084006310 substrate binding site; other site 1155084006311 dimerization interface; other site 1155084006312 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1155084006313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1155084006314 Nucleoside recognition; Region: Gate; pfam07670 1155084006315 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1155084006316 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084006317 ABC-ATPase subunit interface; other site 1155084006318 dimer interface [polypeptide binding]; other site 1155084006319 putative PBP binding regions; other site 1155084006320 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1155084006321 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1155084006322 ABC-ATPase subunit interface; other site 1155084006323 dimer interface [polypeptide binding]; other site 1155084006324 putative PBP binding regions; other site 1155084006325 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1155084006326 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1155084006327 siderophore binding site; other site 1155084006328 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1155084006329 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1155084006330 dimer interface [polypeptide binding]; other site 1155084006331 active site 1155084006332 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1155084006333 substrate binding site [chemical binding]; other site 1155084006334 catalytic residue [active] 1155084006335 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1155084006336 IucA / IucC family; Region: IucA_IucC; pfam04183 1155084006337 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1155084006338 H+ Antiporter protein; Region: 2A0121; TIGR00900 1155084006339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084006340 putative substrate translocation pore; other site 1155084006341 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1155084006342 IucA / IucC family; Region: IucA_IucC; pfam04183 1155084006343 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1155084006344 Asp23 family; Region: Asp23; pfam03780 1155084006345 Small integral membrane protein [Function unknown]; Region: COG5547 1155084006346 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1155084006347 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1155084006348 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1155084006349 putative NAD(P) binding site [chemical binding]; other site 1155084006350 dimer interface [polypeptide binding]; other site 1155084006351 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1155084006352 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1155084006353 NAD(P) binding site [chemical binding]; other site 1155084006354 substrate binding site [chemical binding]; other site 1155084006355 dimer interface [polypeptide binding]; other site 1155084006356 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1155084006357 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1155084006358 beta-galactosidase; Region: BGL; TIGR03356 1155084006359 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1155084006360 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1155084006361 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1155084006362 active site 1155084006363 P-loop; other site 1155084006364 phosphorylation site [posttranslational modification] 1155084006365 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1155084006366 methionine cluster; other site 1155084006367 active site 1155084006368 phosphorylation site [posttranslational modification] 1155084006369 metal binding site [ion binding]; metal-binding site 1155084006370 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1155084006371 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1155084006372 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1155084006373 putative substrate binding site [chemical binding]; other site 1155084006374 putative ATP binding site [chemical binding]; other site 1155084006375 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1155084006376 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1155084006377 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1155084006378 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1155084006379 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1155084006380 NAD-dependent deacetylase; Provisional; Region: PRK00481 1155084006381 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1155084006382 NAD+ binding site [chemical binding]; other site 1155084006383 substrate binding site [chemical binding]; other site 1155084006384 putative Zn binding site [ion binding]; other site 1155084006385 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1155084006386 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1155084006387 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1155084006388 active site 1155084006389 catalytic tetrad [active] 1155084006390 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155084006391 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1155084006392 DNA binding residues [nucleotide binding] 1155084006393 putative dimer interface [polypeptide binding]; other site 1155084006394 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1155084006395 substrate binding site [chemical binding]; other site 1155084006396 catalytic residues [active] 1155084006397 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1155084006398 Peptidase family M23; Region: Peptidase_M23; pfam01551 1155084006399 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1155084006400 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155084006401 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1155084006402 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1155084006403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1155084006404 active site 1155084006405 motif I; other site 1155084006406 motif II; other site 1155084006407 MAP domain; Region: MAP; pfam03642 1155084006408 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1155084006409 acetolactate synthase; Reviewed; Region: PRK08617 1155084006410 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1155084006411 PYR/PP interface [polypeptide binding]; other site 1155084006412 dimer interface [polypeptide binding]; other site 1155084006413 TPP binding site [chemical binding]; other site 1155084006414 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155084006415 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1155084006416 TPP-binding site [chemical binding]; other site 1155084006417 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155084006418 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155084006419 Integrase core domain; Region: rve; pfam00665 1155084006420 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1155084006421 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1155084006422 23S rRNA interface [nucleotide binding]; other site 1155084006423 L3 interface [polypeptide binding]; other site 1155084006424 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1155084006425 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1155084006426 dimerization interface 3.5A [polypeptide binding]; other site 1155084006427 active site 1155084006428 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1155084006429 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1155084006430 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155084006431 Walker A/P-loop; other site 1155084006432 ATP binding site [chemical binding]; other site 1155084006433 Q-loop/lid; other site 1155084006434 ABC transporter signature motif; other site 1155084006435 Walker B; other site 1155084006436 D-loop; other site 1155084006437 H-loop/switch region; other site 1155084006438 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1155084006439 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155084006440 Walker A/P-loop; other site 1155084006441 ATP binding site [chemical binding]; other site 1155084006442 Q-loop/lid; other site 1155084006443 ABC transporter signature motif; other site 1155084006444 Walker B; other site 1155084006445 D-loop; other site 1155084006446 H-loop/switch region; other site 1155084006447 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1155084006448 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1155084006449 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1155084006450 alphaNTD homodimer interface [polypeptide binding]; other site 1155084006451 alphaNTD - beta interaction site [polypeptide binding]; other site 1155084006452 alphaNTD - beta' interaction site [polypeptide binding]; other site 1155084006453 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1155084006454 30S ribosomal protein S11; Validated; Region: PRK05309 1155084006455 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1155084006456 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1155084006457 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1155084006458 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1155084006459 rRNA binding site [nucleotide binding]; other site 1155084006460 predicted 30S ribosome binding site; other site 1155084006461 adenylate kinase; Reviewed; Region: adk; PRK00279 1155084006462 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1155084006463 AMP-binding site [chemical binding]; other site 1155084006464 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1155084006465 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1155084006466 SecY translocase; Region: SecY; pfam00344 1155084006467 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1155084006468 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1155084006469 23S rRNA binding site [nucleotide binding]; other site 1155084006470 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1155084006471 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1155084006472 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1155084006473 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1155084006474 5S rRNA interface [nucleotide binding]; other site 1155084006475 L27 interface [polypeptide binding]; other site 1155084006476 23S rRNA interface [nucleotide binding]; other site 1155084006477 L5 interface [polypeptide binding]; other site 1155084006478 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1155084006479 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1155084006480 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1155084006481 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1155084006482 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1155084006483 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1155084006484 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1155084006485 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1155084006486 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1155084006487 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1155084006488 RNA binding site [nucleotide binding]; other site 1155084006489 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1155084006490 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1155084006491 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1155084006492 23S rRNA interface [nucleotide binding]; other site 1155084006493 putative translocon interaction site; other site 1155084006494 signal recognition particle (SRP54) interaction site; other site 1155084006495 L23 interface [polypeptide binding]; other site 1155084006496 trigger factor interaction site; other site 1155084006497 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1155084006498 23S rRNA interface [nucleotide binding]; other site 1155084006499 5S rRNA interface [nucleotide binding]; other site 1155084006500 putative antibiotic binding site [chemical binding]; other site 1155084006501 L25 interface [polypeptide binding]; other site 1155084006502 L27 interface [polypeptide binding]; other site 1155084006503 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1155084006504 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1155084006505 G-X-X-G motif; other site 1155084006506 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1155084006507 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1155084006508 putative translocon binding site; other site 1155084006509 protein-rRNA interface [nucleotide binding]; other site 1155084006510 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1155084006511 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1155084006512 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1155084006513 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1155084006514 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1155084006515 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1155084006516 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1155084006517 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1155084006518 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1155084006519 DNA topoisomerase III; Provisional; Region: PRK07726 1155084006520 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1155084006521 active site 1155084006522 putative interdomain interaction site [polypeptide binding]; other site 1155084006523 putative metal-binding site [ion binding]; other site 1155084006524 putative nucleotide binding site [chemical binding]; other site 1155084006525 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1155084006526 domain I; other site 1155084006527 DNA binding groove [nucleotide binding] 1155084006528 phosphate binding site [ion binding]; other site 1155084006529 domain II; other site 1155084006530 domain III; other site 1155084006531 nucleotide binding site [chemical binding]; other site 1155084006532 catalytic site [active] 1155084006533 domain IV; other site 1155084006534 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1155084006535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084006536 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1155084006537 Coenzyme A binding pocket [chemical binding]; other site 1155084006538 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1155084006539 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1155084006540 Predicted permeases [General function prediction only]; Region: COG0679 1155084006541 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1155084006542 Protein export membrane protein; Region: SecD_SecF; cl14618 1155084006543 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1155084006544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1155084006545 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1155084006546 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1155084006547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084006548 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084006549 putative substrate translocation pore; other site 1155084006550 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1155084006551 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1155084006552 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1155084006553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084006554 FeS/SAM binding site; other site 1155084006555 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1155084006556 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1155084006557 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1155084006558 GTP binding site; other site 1155084006559 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1155084006560 MoaE interaction surface [polypeptide binding]; other site 1155084006561 MoeB interaction surface [polypeptide binding]; other site 1155084006562 thiocarboxylated glycine; other site 1155084006563 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1155084006564 MoaE homodimer interface [polypeptide binding]; other site 1155084006565 MoaD interaction [polypeptide binding]; other site 1155084006566 active site residues [active] 1155084006567 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1155084006568 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1155084006569 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1155084006570 dimer interface [polypeptide binding]; other site 1155084006571 putative functional site; other site 1155084006572 putative MPT binding site; other site 1155084006573 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1155084006574 trimer interface [polypeptide binding]; other site 1155084006575 dimer interface [polypeptide binding]; other site 1155084006576 putative active site [active] 1155084006577 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1155084006578 MPT binding site; other site 1155084006579 trimer interface [polypeptide binding]; other site 1155084006580 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1155084006581 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1155084006582 ATP binding site [chemical binding]; other site 1155084006583 substrate interface [chemical binding]; other site 1155084006584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084006585 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1155084006586 Walker A/P-loop; other site 1155084006587 ATP binding site [chemical binding]; other site 1155084006588 Q-loop/lid; other site 1155084006589 ABC transporter signature motif; other site 1155084006590 Walker B; other site 1155084006591 D-loop; other site 1155084006592 H-loop/switch region; other site 1155084006593 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1155084006594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084006595 dimer interface [polypeptide binding]; other site 1155084006596 conserved gate region; other site 1155084006597 putative PBP binding loops; other site 1155084006598 ABC-ATPase subunit interface; other site 1155084006599 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1155084006600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155084006601 substrate binding pocket [chemical binding]; other site 1155084006602 membrane-bound complex binding site; other site 1155084006603 hinge residues; other site 1155084006604 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1155084006605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084006606 Coenzyme A binding pocket [chemical binding]; other site 1155084006607 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1155084006608 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1155084006609 active site 1155084006610 dimerization interface [polypeptide binding]; other site 1155084006611 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1155084006612 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1155084006613 intersubunit interface [polypeptide binding]; other site 1155084006614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1155084006615 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1155084006616 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1155084006617 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1155084006618 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1155084006619 alpha-gamma subunit interface [polypeptide binding]; other site 1155084006620 beta-gamma subunit interface [polypeptide binding]; other site 1155084006621 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1155084006622 gamma-beta subunit interface [polypeptide binding]; other site 1155084006623 alpha-beta subunit interface [polypeptide binding]; other site 1155084006624 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1155084006625 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1155084006626 subunit interactions [polypeptide binding]; other site 1155084006627 active site 1155084006628 flap region; other site 1155084006629 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1155084006630 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1155084006631 dimer interface [polypeptide binding]; other site 1155084006632 catalytic residues [active] 1155084006633 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1155084006634 UreF; Region: UreF; pfam01730 1155084006635 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155084006636 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1155084006637 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1155084006638 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1155084006639 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1155084006640 Helix-turn-helix domain; Region: HTH_18; pfam12833 1155084006641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155084006642 Surface antigen [General function prediction only]; Region: COG3942 1155084006643 CHAP domain; Region: CHAP; pfam05257 1155084006644 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1155084006645 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1155084006646 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1155084006647 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1155084006648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1155084006649 Surface antigen [General function prediction only]; Region: COG3942 1155084006650 CHAP domain; Region: CHAP; pfam05257 1155084006651 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1155084006652 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1155084006653 putative ligand binding site [chemical binding]; other site 1155084006654 putative NAD binding site [chemical binding]; other site 1155084006655 catalytic site [active] 1155084006656 hypothetical protein; Provisional; Region: PRK06753 1155084006657 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1155084006658 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084006659 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1155084006660 Lysozyme subfamily 2; Region: LYZ2; smart00047 1155084006661 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1155084006662 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1155084006663 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1155084006664 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1155084006665 4Fe-4S binding domain; Region: Fer4; pfam00037 1155084006666 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1155084006667 [4Fe-4S] binding site [ion binding]; other site 1155084006668 molybdopterin cofactor binding site; other site 1155084006669 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1155084006670 molybdopterin cofactor binding site; other site 1155084006671 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1155084006672 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1155084006673 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1155084006674 active site 1155084006675 Predicted transcriptional regulator [Transcription]; Region: COG2378 1155084006676 HTH domain; Region: HTH_11; pfam08279 1155084006677 CAAX protease self-immunity; Region: Abi; pfam02517 1155084006678 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155084006679 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155084006680 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155084006681 putative active site [active] 1155084006682 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155084006683 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1155084006684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084006685 active site 1155084006686 motif I; other site 1155084006687 motif II; other site 1155084006688 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1155084006689 Sodium Bile acid symporter family; Region: SBF; pfam01758 1155084006690 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1155084006691 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155084006692 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155084006693 active site turn [active] 1155084006694 phosphorylation site [posttranslational modification] 1155084006695 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1155084006696 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1155084006697 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1155084006698 putative active site [active] 1155084006699 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1155084006700 putative hydrophobic ligand binding site [chemical binding]; other site 1155084006701 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1155084006702 oxidoreductase; Provisional; Region: PRK06128 1155084006703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155084006704 NAD(P) binding site [chemical binding]; other site 1155084006705 active site 1155084006706 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1155084006707 amidohydrolase; Region: amidohydrolases; TIGR01891 1155084006708 metal binding site [ion binding]; metal-binding site 1155084006709 dimer interface [polypeptide binding]; other site 1155084006710 imidazolonepropionase; Validated; Region: PRK09356 1155084006711 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1155084006712 active site 1155084006713 urocanate hydratase; Provisional; Region: PRK05414 1155084006714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155084006715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155084006716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1155084006717 dimerization interface [polypeptide binding]; other site 1155084006718 formimidoylglutamase; Provisional; Region: PRK13775 1155084006719 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1155084006720 putative active site [active] 1155084006721 putative metal binding site [ion binding]; other site 1155084006722 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1155084006723 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1155084006724 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155084006725 active site 1155084006726 dimer interface [polypeptide binding]; other site 1155084006727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1155084006728 MOSC domain; Region: MOSC; pfam03473 1155084006729 3-alpha domain; Region: 3-alpha; pfam03475 1155084006730 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1155084006731 active site 1155084006732 catalytic residues [active] 1155084006733 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1155084006734 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1155084006735 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1155084006736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084006737 Walker A/P-loop; other site 1155084006738 ATP binding site [chemical binding]; other site 1155084006739 Q-loop/lid; other site 1155084006740 ABC transporter signature motif; other site 1155084006741 Walker B; other site 1155084006742 D-loop; other site 1155084006743 H-loop/switch region; other site 1155084006744 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1155084006745 Predicted membrane protein [Function unknown]; Region: COG3152 1155084006746 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1155084006747 active site 1155084006748 DNA binding site [nucleotide binding] 1155084006749 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1155084006750 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1155084006751 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1155084006752 homotetramer interface [polypeptide binding]; other site 1155084006753 FMN binding site [chemical binding]; other site 1155084006754 homodimer contacts [polypeptide binding]; other site 1155084006755 putative active site [active] 1155084006756 putative substrate binding site [chemical binding]; other site 1155084006757 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1155084006758 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1155084006759 oligomer interface [polypeptide binding]; other site 1155084006760 metal binding site [ion binding]; metal-binding site 1155084006761 metal binding site [ion binding]; metal-binding site 1155084006762 putative Cl binding site [ion binding]; other site 1155084006763 aspartate ring; other site 1155084006764 basic sphincter; other site 1155084006765 hydrophobic gate; other site 1155084006766 periplasmic entrance; other site 1155084006767 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1155084006768 active site 1155084006769 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1155084006770 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1155084006771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084006772 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1155084006773 putative substrate translocation pore; other site 1155084006774 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1155084006775 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1155084006776 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1155084006777 HlyD family secretion protein; Region: HlyD_3; pfam13437 1155084006778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1155084006779 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1155084006780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084006781 putative substrate translocation pore; other site 1155084006782 Predicted membrane protein [Function unknown]; Region: COG4640 1155084006783 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1155084006784 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155084006785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1155084006786 putative Zn2+ binding site [ion binding]; other site 1155084006787 putative DNA binding site [nucleotide binding]; other site 1155084006788 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1155084006789 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1155084006790 putative active site [active] 1155084006791 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155084006792 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155084006793 Walker A/P-loop; other site 1155084006794 ATP binding site [chemical binding]; other site 1155084006795 Q-loop/lid; other site 1155084006796 ABC transporter signature motif; other site 1155084006797 Walker B; other site 1155084006798 D-loop; other site 1155084006799 H-loop/switch region; other site 1155084006800 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1155084006801 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155084006802 FtsX-like permease family; Region: FtsX; pfam02687 1155084006803 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155084006804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084006805 active site 1155084006806 phosphorylation site [posttranslational modification] 1155084006807 intermolecular recognition site; other site 1155084006808 dimerization interface [polypeptide binding]; other site 1155084006809 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155084006810 DNA binding site [nucleotide binding] 1155084006811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155084006812 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1155084006813 dimerization interface [polypeptide binding]; other site 1155084006814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1155084006815 dimer interface [polypeptide binding]; other site 1155084006816 phosphorylation site [posttranslational modification] 1155084006817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084006818 ATP binding site [chemical binding]; other site 1155084006819 Mg2+ binding site [ion binding]; other site 1155084006820 G-X-G motif; other site 1155084006821 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1155084006822 LytTr DNA-binding domain; Region: LytTR; smart00850 1155084006823 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1155084006824 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 1155084006825 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1155084006826 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1155084006827 L-lactate permease; Region: Lactate_perm; cl00701 1155084006828 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1155084006829 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1155084006830 Helix-turn-helix domain; Region: HTH_38; pfam13936 1155084006831 Integrase core domain; Region: rve; pfam00665 1155084006832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084006833 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1155084006834 Coenzyme A binding pocket [chemical binding]; other site 1155084006835 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1155084006836 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1155084006837 NAD(P) binding site [chemical binding]; other site 1155084006838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084006839 Coenzyme A binding pocket [chemical binding]; other site 1155084006840 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1155084006841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155084006842 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084006843 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1155084006844 Predicted membrane protein [Function unknown]; Region: COG1511 1155084006845 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1155084006846 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1155084006847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155084006848 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1155084006849 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1155084006850 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1155084006851 Cl binding site [ion binding]; other site 1155084006852 oligomer interface [polypeptide binding]; other site 1155084006853 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1155084006854 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155084006855 active site turn [active] 1155084006856 phosphorylation site [posttranslational modification] 1155084006857 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155084006858 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1155084006859 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1155084006860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1155084006861 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1155084006862 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1155084006863 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1155084006864 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1155084006865 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1155084006866 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155084006867 MarR family; Region: MarR_2; pfam12802 1155084006868 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1155084006869 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1155084006870 putative dimer interface [polypeptide binding]; other site 1155084006871 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1155084006872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084006873 putative substrate translocation pore; other site 1155084006874 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084006875 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1155084006876 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1155084006877 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1155084006878 DNA binding residues [nucleotide binding] 1155084006879 dimer interface [polypeptide binding]; other site 1155084006880 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1155084006881 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1155084006882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084006883 active site 1155084006884 phosphorylation site [posttranslational modification] 1155084006885 intermolecular recognition site; other site 1155084006886 dimerization interface [polypeptide binding]; other site 1155084006887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1155084006888 DNA binding residues [nucleotide binding] 1155084006889 dimerization interface [polypeptide binding]; other site 1155084006890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1155084006891 Histidine kinase; Region: HisKA_3; pfam07730 1155084006892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084006893 ATP binding site [chemical binding]; other site 1155084006894 Mg2+ binding site [ion binding]; other site 1155084006895 G-X-G motif; other site 1155084006896 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1155084006897 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1155084006898 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1155084006899 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1155084006900 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1155084006901 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1155084006902 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1155084006903 [4Fe-4S] binding site [ion binding]; other site 1155084006904 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1155084006905 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1155084006906 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1155084006907 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1155084006908 molybdopterin cofactor binding site; other site 1155084006909 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1155084006910 active site 1155084006911 SAM binding site [chemical binding]; other site 1155084006912 homodimer interface [polypeptide binding]; other site 1155084006913 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1155084006914 [2Fe-2S] cluster binding site [ion binding]; other site 1155084006915 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1155084006916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155084006917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1155084006918 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1155084006919 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1155084006920 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1155084006921 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1155084006922 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1155084006923 putative active site [active] 1155084006924 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1155084006925 active site 1155084006926 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1155084006927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084006928 Coenzyme A binding pocket [chemical binding]; other site 1155084006929 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1155084006930 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1155084006931 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1155084006932 putative hydrophobic ligand binding site [chemical binding]; other site 1155084006933 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1155084006934 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1155084006935 intersubunit interface [polypeptide binding]; other site 1155084006936 YodA lipocalin-like domain; Region: YodA; pfam09223 1155084006937 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1155084006938 Thioredoxin; Region: Thioredoxin_4; pfam13462 1155084006939 FemAB family; Region: FemAB; pfam02388 1155084006940 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1155084006941 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1155084006942 Walker A/P-loop; other site 1155084006943 ATP binding site [chemical binding]; other site 1155084006944 Q-loop/lid; other site 1155084006945 ABC transporter signature motif; other site 1155084006946 Walker B; other site 1155084006947 D-loop; other site 1155084006948 H-loop/switch region; other site 1155084006949 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1155084006950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084006951 dimer interface [polypeptide binding]; other site 1155084006952 conserved gate region; other site 1155084006953 putative PBP binding loops; other site 1155084006954 ABC-ATPase subunit interface; other site 1155084006955 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1155084006956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1155084006957 substrate binding pocket [chemical binding]; other site 1155084006958 membrane-bound complex binding site; other site 1155084006959 hinge residues; other site 1155084006960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084006961 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084006962 putative substrate translocation pore; other site 1155084006963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084006964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155084006965 catalytic core [active] 1155084006966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1155084006967 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1155084006968 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1155084006969 B domain; Region: B; pfam02216 1155084006970 B domain; Region: B; pfam02216 1155084006971 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 1155084006972 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1155084006973 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1155084006974 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1155084006975 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1155084006976 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1155084006977 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1155084006978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1155084006979 catalytic residue [active] 1155084006980 biotin synthase; Validated; Region: PRK06256 1155084006981 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084006982 FeS/SAM binding site; other site 1155084006983 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1155084006984 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155084006985 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1155084006986 inhibitor-cofactor binding pocket; inhibition site 1155084006987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084006988 catalytic residue [active] 1155084006989 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1155084006990 AAA domain; Region: AAA_26; pfam13500 1155084006991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084006992 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1155084006993 Walker A/P-loop; other site 1155084006994 ATP binding site [chemical binding]; other site 1155084006995 Q-loop/lid; other site 1155084006996 ABC transporter signature motif; other site 1155084006997 Walker B; other site 1155084006998 D-loop; other site 1155084006999 H-loop/switch region; other site 1155084007000 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1155084007001 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1155084007002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084007003 Walker A/P-loop; other site 1155084007004 ATP binding site [chemical binding]; other site 1155084007005 Q-loop/lid; other site 1155084007006 ABC transporter signature motif; other site 1155084007007 Walker B; other site 1155084007008 D-loop; other site 1155084007009 H-loop/switch region; other site 1155084007010 Predicted membrane protein [Function unknown]; Region: COG2246 1155084007011 GtrA-like protein; Region: GtrA; pfam04138 1155084007012 glycerate kinase; Region: TIGR00045 1155084007013 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1155084007014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084007015 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1155084007016 putative substrate translocation pore; other site 1155084007017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1155084007018 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1155084007019 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1155084007020 putative phosphoesterase; Region: acc_ester; TIGR03729 1155084007021 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1155084007022 Spore germination protein; Region: Spore_permease; cl17796 1155084007023 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1155084007024 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1155084007025 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1155084007026 Beta-lactamase; Region: Beta-lactamase; pfam00144 1155084007027 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1155084007028 extended (e) SDRs; Region: SDR_e; cd08946 1155084007029 NAD(P) binding site [chemical binding]; other site 1155084007030 active site 1155084007031 substrate binding site [chemical binding]; other site 1155084007032 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1155084007033 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1155084007034 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1155084007035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084007036 putative substrate translocation pore; other site 1155084007037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084007038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084007039 dimer interface [polypeptide binding]; other site 1155084007040 conserved gate region; other site 1155084007041 ABC-ATPase subunit interface; other site 1155084007042 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1155084007043 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1155084007044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084007045 dimer interface [polypeptide binding]; other site 1155084007046 conserved gate region; other site 1155084007047 putative PBP binding loops; other site 1155084007048 ABC-ATPase subunit interface; other site 1155084007049 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1155084007050 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1155084007051 Walker A/P-loop; other site 1155084007052 ATP binding site [chemical binding]; other site 1155084007053 Q-loop/lid; other site 1155084007054 ABC transporter signature motif; other site 1155084007055 Walker B; other site 1155084007056 D-loop; other site 1155084007057 H-loop/switch region; other site 1155084007058 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1155084007059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1155084007060 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1155084007061 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1155084007062 amino acid transporter; Region: 2A0306; TIGR00909 1155084007063 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1155084007064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1155084007065 substrate binding pocket [chemical binding]; other site 1155084007066 catalytic triad [active] 1155084007067 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1155084007068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084007069 putative substrate translocation pore; other site 1155084007070 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1155084007071 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1155084007072 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1155084007073 Walker A/P-loop; other site 1155084007074 ATP binding site [chemical binding]; other site 1155084007075 Q-loop/lid; other site 1155084007076 ABC transporter signature motif; other site 1155084007077 Walker B; other site 1155084007078 D-loop; other site 1155084007079 H-loop/switch region; other site 1155084007080 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1155084007081 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1155084007082 oligomer interface [polypeptide binding]; other site 1155084007083 active site 1155084007084 metal binding site [ion binding]; metal-binding site 1155084007085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1155084007086 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1155084007087 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1155084007088 active site 1155084007089 FMN binding site [chemical binding]; other site 1155084007090 substrate binding site [chemical binding]; other site 1155084007091 3Fe-4S cluster binding site [ion binding]; other site 1155084007092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084007093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084007094 putative substrate translocation pore; other site 1155084007095 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1155084007096 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084007097 Walker A/P-loop; other site 1155084007098 ATP binding site [chemical binding]; other site 1155084007099 Q-loop/lid; other site 1155084007100 ABC transporter signature motif; other site 1155084007101 Walker B; other site 1155084007102 D-loop; other site 1155084007103 H-loop/switch region; other site 1155084007104 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1155084007105 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1155084007106 Walker A/P-loop; other site 1155084007107 ATP binding site [chemical binding]; other site 1155084007108 Q-loop/lid; other site 1155084007109 ABC transporter signature motif; other site 1155084007110 Walker B; other site 1155084007111 D-loop; other site 1155084007112 H-loop/switch region; other site 1155084007113 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1155084007114 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1155084007115 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1155084007116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084007117 dimer interface [polypeptide binding]; other site 1155084007118 conserved gate region; other site 1155084007119 putative PBP binding loops; other site 1155084007120 ABC-ATPase subunit interface; other site 1155084007121 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1155084007122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1155084007123 dimer interface [polypeptide binding]; other site 1155084007124 conserved gate region; other site 1155084007125 putative PBP binding loops; other site 1155084007126 ABC-ATPase subunit interface; other site 1155084007127 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1155084007128 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1155084007129 substrate binding site [chemical binding]; other site 1155084007130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1155084007131 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1155084007132 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1155084007133 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1155084007134 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084007135 short chain dehydrogenase; Validated; Region: PRK08589 1155084007136 classical (c) SDRs; Region: SDR_c; cd05233 1155084007137 NAD(P) binding site [chemical binding]; other site 1155084007138 active site 1155084007139 AbgT putative transporter family; Region: ABG_transport; pfam03806 1155084007140 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1155084007141 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1155084007142 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1155084007143 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084007144 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084007145 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084007146 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084007147 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1155084007148 potential frameshift: common BLAST hit: gi|384548863|ref|YP_005738116.1| putative transposase 1155084007149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1155084007150 Helix-turn-helix domain; Region: HTH_28; pfam13518 1155084007151 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1155084007152 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1155084007153 classical (c) SDRs; Region: SDR_c; cd05233 1155084007154 NAD(P) binding site [chemical binding]; other site 1155084007155 active site 1155084007156 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1155084007157 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1155084007158 nucleophilic elbow; other site 1155084007159 catalytic triad; other site 1155084007160 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1155084007161 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1155084007162 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1155084007163 EcoRII C terminal; Region: EcoRII-C; pfam09019 1155084007164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084007165 non-specific DNA binding site [nucleotide binding]; other site 1155084007166 salt bridge; other site 1155084007167 sequence-specific DNA binding site [nucleotide binding]; other site 1155084007168 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1155084007169 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1155084007170 cofactor binding site; other site 1155084007171 DNA binding site [nucleotide binding] 1155084007172 substrate interaction site [chemical binding]; other site 1155084007173 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1155084007174 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1155084007175 active site 1155084007176 substrate binding site [chemical binding]; other site 1155084007177 metal binding site [ion binding]; metal-binding site 1155084007178 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1155084007179 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1155084007180 active site 1155084007181 tetramer interface; other site 1155084007182 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084007183 Mucin-like glycoprotein; Region: Mucin; pfam01456 1155084007184 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1155084007185 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084007186 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1155084007187 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1155084007188 GntP family permease; Region: GntP_permease; pfam02447 1155084007189 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1155084007190 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1155084007191 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1155084007192 N- and C-terminal domain interface [polypeptide binding]; other site 1155084007193 active site 1155084007194 catalytic site [active] 1155084007195 metal binding site [ion binding]; metal-binding site 1155084007196 carbohydrate binding site [chemical binding]; other site 1155084007197 ATP binding site [chemical binding]; other site 1155084007198 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1155084007199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1155084007200 DNA-binding site [nucleotide binding]; DNA binding site 1155084007201 FCD domain; Region: FCD; pfam07729 1155084007202 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1155084007203 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1155084007204 DNA binding residues [nucleotide binding] 1155084007205 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1155084007206 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1155084007207 synthetase active site [active] 1155084007208 NTP binding site [chemical binding]; other site 1155084007209 metal binding site [ion binding]; metal-binding site 1155084007210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1155084007211 Predicted membrane protein [Function unknown]; Region: COG1289 1155084007212 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1155084007213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084007214 D-galactonate transporter; Region: 2A0114; TIGR00893 1155084007215 putative substrate translocation pore; other site 1155084007216 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1155084007217 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1155084007218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1155084007219 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1155084007220 putative substrate translocation pore; other site 1155084007221 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155084007222 MarR family; Region: MarR; pfam01047 1155084007223 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1155084007224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1155084007225 Walker A/P-loop; other site 1155084007226 ATP binding site [chemical binding]; other site 1155084007227 Q-loop/lid; other site 1155084007228 ABC transporter signature motif; other site 1155084007229 Walker B; other site 1155084007230 D-loop; other site 1155084007231 H-loop/switch region; other site 1155084007232 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1155084007233 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1155084007234 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1155084007235 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1155084007236 Predicted esterase [General function prediction only]; Region: COG0400 1155084007237 putative hydrolase; Provisional; Region: PRK11460 1155084007238 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1155084007239 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155084007240 Zn binding site [ion binding]; other site 1155084007241 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1155084007242 Zn binding site [ion binding]; other site 1155084007243 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155084007244 MarR family; Region: MarR; pfam01047 1155084007245 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1155084007246 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1155084007247 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1155084007248 putative metal binding site [ion binding]; other site 1155084007249 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1155084007250 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1155084007251 dimer interface [polypeptide binding]; other site 1155084007252 FMN binding site [chemical binding]; other site 1155084007253 D-lactate dehydrogenase; Provisional; Region: PRK12480 1155084007254 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1155084007255 homodimer interface [polypeptide binding]; other site 1155084007256 ligand binding site [chemical binding]; other site 1155084007257 NAD binding site [chemical binding]; other site 1155084007258 catalytic site [active] 1155084007259 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1155084007260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1155084007261 active site 1155084007262 motif I; other site 1155084007263 motif II; other site 1155084007264 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1155084007265 active site 1155084007266 catalytic site [active] 1155084007267 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1155084007268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084007269 Coenzyme A binding pocket [chemical binding]; other site 1155084007270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1155084007271 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1155084007272 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1155084007273 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1155084007274 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1155084007275 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1155084007276 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155084007277 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1155084007278 EamA-like transporter family; Region: EamA; pfam00892 1155084007279 EamA-like transporter family; Region: EamA; pfam00892 1155084007280 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1155084007281 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1155084007282 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1155084007283 catalytic residues [active] 1155084007284 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1155084007285 active site 1155084007286 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1155084007287 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1155084007288 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1155084007289 active site turn [active] 1155084007290 phosphorylation site [posttranslational modification] 1155084007291 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1155084007292 HPr interaction site; other site 1155084007293 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1155084007294 active site 1155084007295 phosphorylation site [posttranslational modification] 1155084007296 pyruvate oxidase; Provisional; Region: PRK08611 1155084007297 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1155084007298 PYR/PP interface [polypeptide binding]; other site 1155084007299 tetramer interface [polypeptide binding]; other site 1155084007300 dimer interface [polypeptide binding]; other site 1155084007301 TPP binding site [chemical binding]; other site 1155084007302 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1155084007303 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1155084007304 TPP-binding site [chemical binding]; other site 1155084007305 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1155084007306 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1155084007307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1155084007308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1155084007309 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1155084007310 putative dimerization interface [polypeptide binding]; other site 1155084007311 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1155084007312 Surface antigen [General function prediction only]; Region: COG3942 1155084007313 CHAP domain; Region: CHAP; pfam05257 1155084007314 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1155084007315 homodimer interface [polypeptide binding]; other site 1155084007316 catalytic residues [active] 1155084007317 NAD binding site [chemical binding]; other site 1155084007318 substrate binding pocket [chemical binding]; other site 1155084007319 flexible flap; other site 1155084007320 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1155084007321 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1155084007322 dimer interface [polypeptide binding]; other site 1155084007323 active site 1155084007324 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1155084007325 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1155084007326 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1155084007327 DNA binding site [nucleotide binding] 1155084007328 active site 1155084007329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084007330 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1155084007331 Walker A motif; other site 1155084007332 ATP binding site [chemical binding]; other site 1155084007333 Walker B motif; other site 1155084007334 arginine finger; other site 1155084007335 UvrB/uvrC motif; Region: UVR; pfam02151 1155084007336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1155084007337 Walker A motif; other site 1155084007338 ATP binding site [chemical binding]; other site 1155084007339 Walker B motif; other site 1155084007340 arginine finger; other site 1155084007341 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1155084007342 Virus attachment protein p12 family; Region: P12; pfam12669 1155084007343 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1155084007344 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1155084007345 G1 box; other site 1155084007346 GTP/Mg2+ binding site [chemical binding]; other site 1155084007347 Switch I region; other site 1155084007348 G2 box; other site 1155084007349 G3 box; other site 1155084007350 Switch II region; other site 1155084007351 G4 box; other site 1155084007352 G5 box; other site 1155084007353 Nucleoside recognition; Region: Gate; pfam07670 1155084007354 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1155084007355 Nucleoside recognition; Region: Gate; pfam07670 1155084007356 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1155084007357 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1155084007358 Protein export membrane protein; Region: SecD_SecF; cl14618 1155084007359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155084007360 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1155084007361 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1155084007362 Glutamate binding site [chemical binding]; other site 1155084007363 homodimer interface [polypeptide binding]; other site 1155084007364 NAD binding site [chemical binding]; other site 1155084007365 catalytic residues [active] 1155084007366 maltose O-acetyltransferase; Provisional; Region: PRK10092 1155084007367 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1155084007368 active site 1155084007369 substrate binding site [chemical binding]; other site 1155084007370 trimer interface [polypeptide binding]; other site 1155084007371 CoA binding site [chemical binding]; other site 1155084007372 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155084007373 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155084007374 metal-binding site [ion binding] 1155084007375 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155084007376 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155084007377 metal-binding site [ion binding] 1155084007378 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1155084007379 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1155084007380 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1155084007381 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1155084007382 metal-binding site [ion binding] 1155084007383 D-lactate dehydrogenase; Validated; Region: PRK08605 1155084007384 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1155084007385 homodimer interface [polypeptide binding]; other site 1155084007386 ligand binding site [chemical binding]; other site 1155084007387 NAD binding site [chemical binding]; other site 1155084007388 catalytic site [active] 1155084007389 transaminase; Reviewed; Region: PRK08068 1155084007390 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155084007391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084007392 homodimer interface [polypeptide binding]; other site 1155084007393 catalytic residue [active] 1155084007394 phytoene desaturase; Region: crtI_fam; TIGR02734 1155084007395 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155084007396 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1155084007397 active site lid residues [active] 1155084007398 substrate binding pocket [chemical binding]; other site 1155084007399 catalytic residues [active] 1155084007400 substrate-Mg2+ binding site; other site 1155084007401 aspartate-rich region 1; other site 1155084007402 aspartate-rich region 2; other site 1155084007403 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1155084007404 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1155084007405 active site 1155084007406 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1155084007407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1155084007408 Adenylosuccinate lyase C-terminus; Region: ADSL_C; cl17237 1155084007409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1155084007410 Surface antigen [General function prediction only]; Region: COG3942 1155084007411 CHAP domain; Region: CHAP; pfam05257 1155084007412 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1155084007413 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1155084007414 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1155084007415 catalytic triad [active] 1155084007416 catalytic triad [active] 1155084007417 oxyanion hole [active] 1155084007418 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1155084007419 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1155084007420 catalytic residue [active] 1155084007421 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1155084007422 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1155084007423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155084007424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155084007425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1155084007426 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084007427 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1155084007428 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155084007429 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1155084007430 NmrA-like family; Region: NmrA; pfam05368 1155084007431 NADP binding site [chemical binding]; other site 1155084007432 active site 1155084007433 regulatory binding site [polypeptide binding]; other site 1155084007434 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 1155084007435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155084007436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155084007437 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1155084007438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1155084007439 NAD(P) binding site [chemical binding]; other site 1155084007440 active site 1155084007441 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1155084007442 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1155084007443 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1155084007444 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1155084007445 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1155084007446 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1155084007447 Nucleoside recognition; Region: Gate; pfam07670 1155084007448 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1155084007449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1155084007450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 1155084007451 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 1155084007452 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1155084007453 Phosphotransferase enzyme family; Region: APH; pfam01636 1155084007454 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1155084007455 active site 1155084007456 ATP binding site [chemical binding]; other site 1155084007457 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1155084007458 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1155084007459 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1155084007460 quinone interaction residues [chemical binding]; other site 1155084007461 active site 1155084007462 catalytic residues [active] 1155084007463 FMN binding site [chemical binding]; other site 1155084007464 substrate binding site [chemical binding]; other site 1155084007465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1155084007466 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1155084007467 dimer interface [polypeptide binding]; other site 1155084007468 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1155084007469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155084007470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155084007471 Predicted acyl esterases [General function prediction only]; Region: COG2936 1155084007472 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1155084007473 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1155084007474 tetramerization interface [polypeptide binding]; other site 1155084007475 active site 1155084007476 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1155084007477 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1155084007478 active site 1155084007479 ATP-binding site [chemical binding]; other site 1155084007480 pantoate-binding site; other site 1155084007481 HXXH motif; other site 1155084007482 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1155084007483 oligomerization interface [polypeptide binding]; other site 1155084007484 active site 1155084007485 metal binding site [ion binding]; metal-binding site 1155084007486 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1155084007487 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1155084007488 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1155084007489 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1155084007490 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1155084007491 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1155084007492 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1155084007493 NAD binding site [chemical binding]; other site 1155084007494 dimer interface [polypeptide binding]; other site 1155084007495 substrate binding site [chemical binding]; other site 1155084007496 amino acid transporter; Region: 2A0306; TIGR00909 1155084007497 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1155084007498 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1155084007499 inhibitor-cofactor binding pocket; inhibition site 1155084007500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084007501 catalytic residue [active] 1155084007502 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1155084007503 catalytic residue [active] 1155084007504 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1155084007505 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1155084007506 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1155084007507 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1155084007508 acyl-activating enzyme (AAE) consensus motif; other site 1155084007509 AMP binding site [chemical binding]; other site 1155084007510 active site 1155084007511 CoA binding site [chemical binding]; other site 1155084007512 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1155084007513 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1155084007514 choline dehydrogenase; Validated; Region: PRK02106 1155084007515 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1155084007516 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1155084007517 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1155084007518 tetramerization interface [polypeptide binding]; other site 1155084007519 NAD(P) binding site [chemical binding]; other site 1155084007520 catalytic residues [active] 1155084007521 Predicted transcriptional regulators [Transcription]; Region: COG1510 1155084007522 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1155084007523 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1155084007524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1155084007525 FeS/SAM binding site; other site 1155084007526 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1155084007527 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1155084007528 effector binding site; other site 1155084007529 active site 1155084007530 Zn binding site [ion binding]; other site 1155084007531 glycine loop; other site 1155084007532 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1155084007533 Citrate transporter; Region: CitMHS; pfam03600 1155084007534 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1155084007535 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1155084007536 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1155084007537 Flavodoxin; Region: Flavodoxin_1; pfam00258 1155084007538 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1155084007539 FAD binding pocket [chemical binding]; other site 1155084007540 FAD binding motif [chemical binding]; other site 1155084007541 catalytic residues [active] 1155084007542 NAD binding pocket [chemical binding]; other site 1155084007543 phosphate binding motif [ion binding]; other site 1155084007544 beta-alpha-beta structure motif; other site 1155084007545 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1155084007546 catalytic residues [active] 1155084007547 dimer interface [polypeptide binding]; other site 1155084007548 FtsX-like permease family; Region: FtsX; pfam02687 1155084007549 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155084007550 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155084007551 Walker A/P-loop; other site 1155084007552 ATP binding site [chemical binding]; other site 1155084007553 Q-loop/lid; other site 1155084007554 ABC transporter signature motif; other site 1155084007555 Walker B; other site 1155084007556 D-loop; other site 1155084007557 H-loop/switch region; other site 1155084007558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1155084007559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1155084007560 ATP binding site [chemical binding]; other site 1155084007561 Mg2+ binding site [ion binding]; other site 1155084007562 G-X-G motif; other site 1155084007563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1155084007564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1155084007565 active site 1155084007566 phosphorylation site [posttranslational modification] 1155084007567 intermolecular recognition site; other site 1155084007568 dimerization interface [polypeptide binding]; other site 1155084007569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1155084007570 DNA binding site [nucleotide binding] 1155084007571 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1155084007572 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1155084007573 dimer interface [polypeptide binding]; other site 1155084007574 active site 1155084007575 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1155084007576 Protein of unknown function (DUF2648); Region: DUF2648; pfam10855 1155084007577 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1155084007578 MarR family; Region: MarR_2; pfam12802 1155084007579 Predicted esterase [General function prediction only]; Region: COG0627 1155084007580 S-formylglutathione hydrolase; Region: PLN02442 1155084007581 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1155084007582 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1155084007583 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1155084007584 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1155084007585 ligand binding site [chemical binding]; other site 1155084007586 flexible hinge region; other site 1155084007587 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1155084007588 carbamate kinase; Reviewed; Region: PRK12686 1155084007589 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1155084007590 putative substrate binding site [chemical binding]; other site 1155084007591 nucleotide binding site [chemical binding]; other site 1155084007592 nucleotide binding site [chemical binding]; other site 1155084007593 homodimer interface [polypeptide binding]; other site 1155084007594 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1155084007595 ornithine carbamoyltransferase; Validated; Region: PRK02102 1155084007596 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1155084007597 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1155084007598 arginine deiminase; Provisional; Region: PRK01388 1155084007599 Arginine repressor [Transcription]; Region: ArgR; COG1438 1155084007600 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1155084007601 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1155084007602 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1155084007603 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1155084007604 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1155084007605 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1155084007606 active site 1155084007607 Zn binding site [ion binding]; other site 1155084007608 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1155084007609 HTH domain; Region: HTH_11; pfam08279 1155084007610 PRD domain; Region: PRD; pfam00874 1155084007611 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1155084007612 active site 1155084007613 P-loop; other site 1155084007614 phosphorylation site [posttranslational modification] 1155084007615 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155084007616 active site 1155084007617 phosphorylation site [posttranslational modification] 1155084007618 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1155084007619 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1155084007620 active site 1155084007621 P-loop; other site 1155084007622 phosphorylation site [posttranslational modification] 1155084007623 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1155084007624 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1155084007625 active site 1155084007626 phosphorylation site [posttranslational modification] 1155084007627 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1155084007628 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1155084007629 Predicted membrane protein [Function unknown]; Region: COG1511 1155084007630 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1155084007631 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1155084007632 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1155084007633 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1155084007634 CHAP domain; Region: CHAP; pfam05257 1155084007635 Isochorismatase family; Region: Isochorismatase; pfam00857 1155084007636 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1155084007637 catalytic triad [active] 1155084007638 conserved cis-peptide bond; other site 1155084007639 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1155084007640 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155084007641 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1155084007642 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1155084007643 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1155084007644 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1155084007645 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1155084007646 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1155084007647 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1155084007648 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1155084007649 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1155084007650 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1155084007651 SecY translocase; Region: SecY; pfam00344 1155084007652 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1155084007653 legume lectins; Region: lectin_L-type; cd01951 1155084007654 homotetramer interaction site [polypeptide binding]; other site 1155084007655 carbohydrate binding site [chemical binding]; other site 1155084007656 metal binding site [ion binding]; metal-binding site 1155084007657 Putative Ig domain; Region: He_PIG; pfam05345 1155084007658 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1155084007659 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1155084007660 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1155084007661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1155084007662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1155084007663 Coenzyme A binding pocket [chemical binding]; other site 1155084007664 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1155084007665 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1155084007666 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1155084007667 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1155084007668 Chain length determinant protein; Region: Wzz; cl15801 1155084007669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1155084007670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1155084007671 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1155084007672 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1155084007673 DXD motif; other site 1155084007674 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 1155084007675 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1155084007676 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1155084007677 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1155084007678 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1155084007679 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1155084007680 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1155084007681 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1155084007682 metal binding site [ion binding]; metal-binding site 1155084007683 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1155084007684 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1155084007685 substrate binding site [chemical binding]; other site 1155084007686 glutamase interaction surface [polypeptide binding]; other site 1155084007687 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1155084007688 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1155084007689 catalytic residues [active] 1155084007690 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1155084007691 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1155084007692 putative active site [active] 1155084007693 oxyanion strand; other site 1155084007694 catalytic triad [active] 1155084007695 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1155084007696 putative active site pocket [active] 1155084007697 4-fold oligomerization interface [polypeptide binding]; other site 1155084007698 metal binding residues [ion binding]; metal-binding site 1155084007699 3-fold/trimer interface [polypeptide binding]; other site 1155084007700 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1155084007701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1155084007702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1155084007703 homodimer interface [polypeptide binding]; other site 1155084007704 catalytic residue [active] 1155084007705 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1155084007706 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1155084007707 NAD binding site [chemical binding]; other site 1155084007708 dimerization interface [polypeptide binding]; other site 1155084007709 product binding site; other site 1155084007710 substrate binding site [chemical binding]; other site 1155084007711 zinc binding site [ion binding]; other site 1155084007712 catalytic residues [active] 1155084007713 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 1155084007714 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1155084007715 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1155084007716 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1155084007717 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1155084007718 putative active site [active] 1155084007719 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1155084007720 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1155084007721 Strictosidine synthase; Region: Str_synth; pfam03088 1155084007722 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1155084007723 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1155084007724 active site residue [active] 1155084007725 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1155084007726 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1155084007727 putative substrate binding pocket [chemical binding]; other site 1155084007728 AC domain interface; other site 1155084007729 catalytic triad [active] 1155084007730 AB domain interface; other site 1155084007731 interchain disulfide; other site 1155084007732 hypothetical protein; Validated; Region: PRK07668 1155084007733 Predicted transcriptional regulators [Transcription]; Region: COG1695 1155084007734 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1155084007735 DinB superfamily; Region: DinB_2; pfam12867 1155084007736 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1155084007737 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1155084007738 transmembrane helices; other site 1155084007739 Protein of unknown function (DUF3125); Region: DUF3125; pfam11323 1155084007740 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1155084007741 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1155084007742 hypothetical protein; Provisional; Region: PRK07758 1155084007743 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1155084007744 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1155084007745 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1155084007746 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1155084007747 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1155084007748 Walker A/P-loop; other site 1155084007749 ATP binding site [chemical binding]; other site 1155084007750 Q-loop/lid; other site 1155084007751 ABC transporter signature motif; other site 1155084007752 Walker B; other site 1155084007753 D-loop; other site 1155084007754 H-loop/switch region; other site 1155084007755 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1155084007756 FtsX-like permease family; Region: FtsX; pfam02687 1155084007757 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1155084007758 DNA-binding site [nucleotide binding]; DNA binding site 1155084007759 RNA-binding motif; other site 1155084007760 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1155084007761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1155084007762 non-specific DNA binding site [nucleotide binding]; other site 1155084007763 salt bridge; other site 1155084007764 sequence-specific DNA binding site [nucleotide binding]; other site 1155084007765 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1155084007766 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1155084007767 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1155084007768 ParB-like nuclease domain; Region: ParBc; pfam02195 1155084007769 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1155084007770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1155084007771 S-adenosylmethionine binding site [chemical binding]; other site 1155084007772 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1155084007773 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1155084007774 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1155084007775 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1155084007776 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1155084007777 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1155084007778 G1 box; other site 1155084007779 GTP/Mg2+ binding site [chemical binding]; other site 1155084007780 Switch I region; other site 1155084007781 G2 box; other site 1155084007782 Switch II region; other site 1155084007783 G3 box; other site 1155084007784 G4 box; other site 1155084007785 G5 box; other site 1155084007786 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1155084007787 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1155084007788 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399