-- dump date 20140620_073158 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1123523000001 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1123523000002 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1123523000003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1123523000004 Integrase core domain; Region: rve; pfam00665 1123523000005 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1123523000006 beta-lactamase TEM; Provisional; Region: PRK15442 1123523000007 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1123523000008 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1123523000009 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1123523000010 Predicted transcriptional regulator [Transcription]; Region: COG3682 1123523000011 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1123523000012 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1123523000013 catalytic residues [active] 1123523000014 catalytic nucleophile [active] 1123523000015 Presynaptic Site I dimer interface [polypeptide binding]; other site 1123523000016 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1123523000017 Synaptic Flat tetramer interface [polypeptide binding]; other site 1123523000018 Synaptic Site I dimer interface [polypeptide binding]; other site 1123523000019 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1123523000020 DNA-binding interface [nucleotide binding]; DNA binding site 1123523000021 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1123523000022 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1123523000023 catalytic residues [active] 1123523000024 catalytic nucleophile [active] 1123523000025 Presynaptic Site I dimer interface [polypeptide binding]; other site 1123523000026 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1123523000027 Synaptic Flat tetramer interface [polypeptide binding]; other site 1123523000028 Synaptic Site I dimer interface [polypeptide binding]; other site 1123523000029 DNA binding site [nucleotide binding] 1123523000030 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1123523000031 DNA-binding interface [nucleotide binding]; DNA binding site 1123523000032 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1123523000033 dimerization interface [polypeptide binding]; other site 1123523000034 putative DNA binding site [nucleotide binding]; other site 1123523000035 putative Zn2+ binding site [ion binding]; other site 1123523000036 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1123523000037 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1123523000038 metal-binding site [ion binding] 1123523000039 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1123523000040 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1123523000041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1123523000042 Integrase core domain; Region: rve; pfam00665 1123523000043 Predicted membrane protein [Function unknown]; Region: COG2855 1123523000044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1123523000045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1123523000046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1123523000047 dimerization interface [polypeptide binding]; other site 1123523000048 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1123523000049 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1123523000050 ATP binding site [chemical binding]; other site 1123523000051 substrate binding site [chemical binding]; other site 1123523000052 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1123523000053 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1123523000054 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 1123523000055 Alkylmercury lyase; Region: MerB; pfam03243 1123523000056 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 1123523000057 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1123523000058 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1123523000059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523000060 Walker A motif; other site 1123523000061 ATP binding site [chemical binding]; other site 1123523000062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1123523000063 Walker B motif; other site 1123523000064 arginine finger; other site 1123523000065 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1123523000066 DnaA box-binding interface [nucleotide binding]; other site 1123523000067 DNA polymerase III subunit beta; Validated; Region: PRK05643 1123523000068 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1123523000069 putative DNA binding surface [nucleotide binding]; other site 1123523000070 dimer interface [polypeptide binding]; other site 1123523000071 beta-clamp/clamp loader binding surface; other site 1123523000072 beta-clamp/translesion DNA polymerase binding surface; other site 1123523000073 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1123523000074 recF protein; Region: recf; TIGR00611 1123523000075 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1123523000076 Walker A/P-loop; other site 1123523000077 ATP binding site [chemical binding]; other site 1123523000078 Q-loop/lid; other site 1123523000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523000080 ABC transporter signature motif; other site 1123523000081 Walker B; other site 1123523000082 D-loop; other site 1123523000083 H-loop/switch region; other site 1123523000084 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1123523000085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523000086 Mg2+ binding site [ion binding]; other site 1123523000087 G-X-G motif; other site 1123523000088 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1123523000089 anchoring element; other site 1123523000090 dimer interface [polypeptide binding]; other site 1123523000091 ATP binding site [chemical binding]; other site 1123523000092 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1123523000093 active site 1123523000094 putative metal-binding site [ion binding]; other site 1123523000095 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1123523000096 DNA gyrase subunit A; Validated; Region: PRK05560 1123523000097 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1123523000098 CAP-like domain; other site 1123523000099 active site 1123523000100 primary dimer interface [polypeptide binding]; other site 1123523000101 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1123523000102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1123523000103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1123523000104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1123523000105 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1123523000106 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1123523000107 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1123523000108 putative substrate binding site [chemical binding]; other site 1123523000109 putative ATP binding site [chemical binding]; other site 1123523000110 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1123523000111 active sites [active] 1123523000112 tetramer interface [polypeptide binding]; other site 1123523000113 seryl-tRNA synthetase; Provisional; Region: PRK05431 1123523000114 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1123523000115 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1123523000116 dimer interface [polypeptide binding]; other site 1123523000117 active site 1123523000118 motif 1; other site 1123523000119 motif 2; other site 1123523000120 motif 3; other site 1123523000121 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1123523000122 Predicted membrane protein [Function unknown]; Region: COG4392 1123523000123 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1123523000124 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1123523000125 Predicted membrane protein [Function unknown]; Region: COG4241 1123523000126 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1123523000127 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1123523000128 DHH family; Region: DHH; pfam01368 1123523000129 DHHA1 domain; Region: DHHA1; pfam02272 1123523000130 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1123523000131 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1123523000132 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1123523000133 replicative DNA helicase; Region: DnaB; TIGR00665 1123523000134 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1123523000135 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1123523000136 Walker A motif; other site 1123523000137 ATP binding site [chemical binding]; other site 1123523000138 Walker B motif; other site 1123523000139 DNA binding loops [nucleotide binding] 1123523000140 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1123523000141 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1123523000142 GDP-binding site [chemical binding]; other site 1123523000143 ACT binding site; other site 1123523000144 IMP binding site; other site 1123523000145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523000146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523000147 active site 1123523000148 phosphorylation site [posttranslational modification] 1123523000149 intermolecular recognition site; other site 1123523000150 dimerization interface [polypeptide binding]; other site 1123523000151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523000152 DNA binding site [nucleotide binding] 1123523000153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1123523000154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1123523000155 dimerization interface [polypeptide binding]; other site 1123523000156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1123523000157 putative active site [active] 1123523000158 heme pocket [chemical binding]; other site 1123523000159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1123523000160 dimer interface [polypeptide binding]; other site 1123523000161 phosphorylation site [posttranslational modification] 1123523000162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523000163 ATP binding site [chemical binding]; other site 1123523000164 Mg2+ binding site [ion binding]; other site 1123523000165 G-X-G motif; other site 1123523000166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1123523000167 YycH protein; Region: YycH; pfam07435 1123523000168 YycH protein; Region: YycI; cl02015 1123523000169 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1123523000170 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1123523000171 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1123523000172 putative active site [active] 1123523000173 putative metal binding site [ion binding]; other site 1123523000174 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1123523000175 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1123523000176 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1123523000177 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1123523000178 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1123523000179 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 1123523000180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1123523000181 Integrase core domain; Region: rve; pfam00665 1123523000182 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1123523000183 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1123523000184 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1123523000185 putative active site [active] 1123523000186 catalytic site [active] 1123523000187 putative metal binding site [ion binding]; other site 1123523000188 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1123523000189 putative active site [active] 1123523000190 putative catalytic site [active] 1123523000191 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1123523000192 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1123523000193 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1123523000194 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1123523000195 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1123523000196 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1123523000197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1123523000198 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1123523000199 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1123523000200 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1123523000201 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1123523000202 Staphylococcus protein of unknown function (DUF950); Region: DUF950; pfam06106 1123523000203 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 1123523000204 Helix-turn-helix domain; Region: HTH_28; pfam13518 1123523000205 Winged helix-turn helix; Region: HTH_29; pfam13551 1123523000206 Integrase core domain; Region: rve; pfam00665 1123523000207 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1123523000208 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1123523000209 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1123523000210 catalytic residues [active] 1123523000211 catalytic nucleophile [active] 1123523000212 Presynaptic Site I dimer interface [polypeptide binding]; other site 1123523000213 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1123523000214 Synaptic Flat tetramer interface [polypeptide binding]; other site 1123523000215 Synaptic Site I dimer interface [polypeptide binding]; other site 1123523000216 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1123523000217 DNA-binding interface [nucleotide binding]; DNA binding site 1123523000218 Predicted transcriptional regulator [Transcription]; Region: COG3682 1123523000219 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1123523000220 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1123523000221 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1123523000222 beta-lactamase TEM; Provisional; Region: PRK15442 1123523000223 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1123523000224 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1123523000225 Phosphotransferase enzyme family; Region: APH; pfam01636 1123523000226 putative active site [active] 1123523000227 putative substrate binding site [chemical binding]; other site 1123523000228 ATP binding site [chemical binding]; other site 1123523000229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523000230 ABC transporter; Region: ABC_tran; pfam00005 1123523000231 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523000232 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1123523000233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1123523000234 Integrase core domain; Region: rve; pfam00665 1123523000235 Lysine efflux permease [General function prediction only]; Region: COG1279 1123523000236 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1123523000237 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1123523000238 putative di-iron ligands [ion binding]; other site 1123523000239 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1123523000240 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1123523000241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1123523000242 DNA-binding site [nucleotide binding]; DNA binding site 1123523000243 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1123523000244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523000245 homodimer interface [polypeptide binding]; other site 1123523000246 catalytic residue [active] 1123523000247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1123523000248 Integrase core domain; Region: rve; pfam00665 1123523000249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523000250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523000251 active site 1123523000252 phosphorylation site [posttranslational modification] 1123523000253 intermolecular recognition site; other site 1123523000254 dimerization interface [polypeptide binding]; other site 1123523000255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523000256 DNA binding site [nucleotide binding] 1123523000257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1123523000258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523000259 ATP binding site [chemical binding]; other site 1123523000260 Mg2+ binding site [ion binding]; other site 1123523000261 G-X-G motif; other site 1123523000262 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1123523000263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523000264 Walker A/P-loop; other site 1123523000265 ATP binding site [chemical binding]; other site 1123523000266 Q-loop/lid; other site 1123523000267 ABC transporter signature motif; other site 1123523000268 Walker B; other site 1123523000269 D-loop; other site 1123523000270 H-loop/switch region; other site 1123523000271 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1123523000272 Bacitracin resistance protein BacA; Region: BacA; cl00858 1123523000273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1123523000274 Integrase core domain; Region: rve; pfam00665 1123523000275 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1123523000276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523000277 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1123523000278 Coenzyme A binding pocket [chemical binding]; other site 1123523000279 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1123523000280 active site 1123523000281 ATP binding site [chemical binding]; other site 1123523000282 Phosphotransferase enzyme family; Region: APH; pfam01636 1123523000283 antibiotic binding site [chemical binding]; other site 1123523000284 Predicted transcriptional regulator [Transcription]; Region: COG2378 1123523000285 HTH domain; Region: HTH_11; pfam08279 1123523000286 WYL domain; Region: WYL; pfam13280 1123523000287 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1123523000288 RibD C-terminal domain; Region: RibD_C; cl17279 1123523000289 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1123523000290 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1123523000291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1123523000292 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1123523000293 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1123523000294 catalytic residues [active] 1123523000295 catalytic nucleophile [active] 1123523000296 Presynaptic Site I dimer interface [polypeptide binding]; other site 1123523000297 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1123523000298 Synaptic Flat tetramer interface [polypeptide binding]; other site 1123523000299 Synaptic Site I dimer interface [polypeptide binding]; other site 1123523000300 DNA binding site [nucleotide binding] 1123523000301 Recombinase; Region: Recombinase; pfam07508 1123523000302 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1123523000303 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 1123523000304 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1123523000305 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1123523000306 catalytic residues [active] 1123523000307 catalytic nucleophile [active] 1123523000308 Recombinase; Region: Recombinase; pfam07508 1123523000309 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1123523000310 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1123523000311 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1123523000312 Divergent AAA domain; Region: AAA_4; pfam04326 1123523000313 Abortive infection C-terminus; Region: Abi_C; pfam14355 1123523000314 Protein of unknown function DUF262; Region: DUF262; pfam03235 1123523000315 Restriction endonuclease FokI, recognition domain; Region: FokI_N; pfam02981 1123523000316 Restriction endonuclease FokI, catalytic domain; Region: FokI_C; pfam02980 1123523000317 Restriction endonuclease FokI, C terminal; Region: Endonuc-FokI_C; pfam09254 1123523000318 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1123523000319 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1123523000320 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1123523000321 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1123523000322 FMN binding site [chemical binding]; other site 1123523000323 active site 1123523000324 catalytic residues [active] 1123523000325 substrate binding site [chemical binding]; other site 1123523000326 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1123523000327 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1123523000328 Part of AAA domain; Region: AAA_19; pfam13245 1123523000329 AAA domain; Region: AAA_12; pfam13087 1123523000330 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1123523000331 active site 1123523000332 catalytic site [active] 1123523000333 putative metal binding site [ion binding]; other site 1123523000334 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523000335 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523000336 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523000337 Esterase/lipase [General function prediction only]; Region: COG1647 1123523000338 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1123523000339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1123523000340 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1123523000341 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1123523000342 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1123523000343 metal binding site [ion binding]; metal-binding site 1123523000344 dimer interface [polypeptide binding]; other site 1123523000345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523000346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523000347 putative substrate translocation pore; other site 1123523000348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523000349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1123523000350 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1123523000351 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1123523000352 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1123523000353 PhoU domain; Region: PhoU; pfam01895 1123523000354 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 1123523000355 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1123523000356 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1123523000357 L-lactate permease; Region: Lactate_perm; cl00701 1123523000358 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523000359 B domain; Region: B; pfam02216 1123523000360 B domain; Region: B; pfam02216 1123523000361 B domain; Region: B; pfam02216 1123523000362 B domain; Region: B; pfam02216 1123523000363 B domain; Region: B; pfam02216 1123523000364 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1123523000365 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523000366 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1123523000367 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523000368 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1123523000369 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1123523000370 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523000371 ABC-ATPase subunit interface; other site 1123523000372 dimer interface [polypeptide binding]; other site 1123523000373 putative PBP binding regions; other site 1123523000374 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1123523000375 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523000376 ABC-ATPase subunit interface; other site 1123523000377 dimer interface [polypeptide binding]; other site 1123523000378 putative PBP binding regions; other site 1123523000379 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1123523000380 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1123523000381 siderophore binding site; other site 1123523000382 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1123523000383 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1123523000384 dimer interface [polypeptide binding]; other site 1123523000385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523000386 catalytic residue [active] 1123523000387 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1123523000388 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1123523000389 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1123523000390 IucA / IucC family; Region: IucA_IucC; pfam04183 1123523000391 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1123523000392 drug efflux system protein MdtG; Provisional; Region: PRK09874 1123523000393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523000394 putative substrate translocation pore; other site 1123523000395 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1123523000396 IucA / IucC family; Region: IucA_IucC; pfam04183 1123523000397 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1123523000398 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1123523000399 IucA / IucC family; Region: IucA_IucC; pfam04183 1123523000400 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1123523000401 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1123523000402 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1123523000403 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1123523000404 dimer interface [polypeptide binding]; other site 1123523000405 active site 1123523000406 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1123523000407 catalytic residues [active] 1123523000408 substrate binding site [chemical binding]; other site 1123523000409 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1123523000410 ParB-like nuclease domain; Region: ParBc; pfam02195 1123523000411 acetoin reductase; Validated; Region: PRK08643 1123523000412 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1123523000413 NAD binding site [chemical binding]; other site 1123523000414 homotetramer interface [polypeptide binding]; other site 1123523000415 homodimer interface [polypeptide binding]; other site 1123523000416 active site 1123523000417 substrate binding site [chemical binding]; other site 1123523000418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1123523000419 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1123523000420 NAD(P) binding site [chemical binding]; other site 1123523000421 active site 1123523000422 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1123523000423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1123523000424 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1123523000425 putative ADP-binding pocket [chemical binding]; other site 1123523000426 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1123523000427 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1123523000428 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1123523000429 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1123523000430 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1123523000431 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1123523000432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1123523000433 DNA-binding site [nucleotide binding]; DNA binding site 1123523000434 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1123523000435 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1123523000436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523000437 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1123523000438 intersubunit interface [polypeptide binding]; other site 1123523000439 active site 1123523000440 catalytic residue [active] 1123523000441 phosphopentomutase; Provisional; Region: PRK05362 1123523000442 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1123523000443 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1123523000444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523000445 dimer interface [polypeptide binding]; other site 1123523000446 conserved gate region; other site 1123523000447 putative PBP binding loops; other site 1123523000448 ABC-ATPase subunit interface; other site 1123523000449 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1123523000450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523000451 dimer interface [polypeptide binding]; other site 1123523000452 conserved gate region; other site 1123523000453 ABC-ATPase subunit interface; other site 1123523000454 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1123523000455 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1123523000456 Walker A/P-loop; other site 1123523000457 ATP binding site [chemical binding]; other site 1123523000458 Q-loop/lid; other site 1123523000459 ABC transporter signature motif; other site 1123523000460 Walker B; other site 1123523000461 D-loop; other site 1123523000462 H-loop/switch region; other site 1123523000463 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1123523000464 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1123523000465 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1123523000466 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1123523000467 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1123523000468 active site 1123523000469 metal binding site [ion binding]; metal-binding site 1123523000470 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1123523000471 Replication initiation factor; Region: Rep_trans; pfam02486 1123523000472 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1123523000473 Transposase IS200 like; Region: Y1_Tnp; cl00848 1123523000474 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1123523000475 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1123523000476 putative catalytic cysteine [active] 1123523000477 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1123523000478 putative active site [active] 1123523000479 metal binding site [ion binding]; metal-binding site 1123523000480 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1123523000481 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1123523000482 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1123523000483 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1123523000484 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1123523000485 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1123523000486 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1123523000487 NAD(P) binding site [chemical binding]; other site 1123523000488 homodimer interface [polypeptide binding]; other site 1123523000489 substrate binding site [chemical binding]; other site 1123523000490 active site 1123523000491 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1123523000492 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1123523000493 NAD(P) binding site [chemical binding]; other site 1123523000494 homodimer interface [polypeptide binding]; other site 1123523000495 substrate binding site [chemical binding]; other site 1123523000496 active site 1123523000497 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1123523000498 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1123523000499 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1123523000500 putative NAD(P) binding site [chemical binding]; other site 1123523000501 active site 1123523000502 putative substrate binding site [chemical binding]; other site 1123523000503 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1123523000504 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1123523000505 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1123523000506 active site 1123523000507 homodimer interface [polypeptide binding]; other site 1123523000508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1123523000509 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1123523000510 trimer interface [polypeptide binding]; other site 1123523000511 active site 1123523000512 substrate binding site [chemical binding]; other site 1123523000513 CoA binding site [chemical binding]; other site 1123523000514 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1123523000515 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1123523000516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1123523000517 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1123523000518 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 1123523000519 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1123523000520 putative NAD(P) binding site [chemical binding]; other site 1123523000521 active site 1123523000522 putative substrate binding site [chemical binding]; other site 1123523000523 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1123523000524 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1123523000525 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1123523000526 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1123523000527 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1123523000528 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1123523000529 active site 1123523000530 homodimer interface [polypeptide binding]; other site 1123523000531 heme-degrading monooxygenase IsdI; Provisional; Region: PRK13313 1123523000532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1123523000533 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 1123523000534 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1123523000535 NAD(P) binding site [chemical binding]; other site 1123523000536 catalytic residues [active] 1123523000537 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1123523000538 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1123523000539 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1123523000540 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1123523000541 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1123523000542 Walker A/P-loop; other site 1123523000543 ATP binding site [chemical binding]; other site 1123523000544 Q-loop/lid; other site 1123523000545 ABC transporter signature motif; other site 1123523000546 Walker B; other site 1123523000547 D-loop; other site 1123523000548 H-loop/switch region; other site 1123523000549 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1123523000550 NMT1-like family; Region: NMT1_2; pfam13379 1123523000551 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1123523000552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1123523000553 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1123523000554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1123523000555 active site 1123523000556 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1123523000557 formate dehydrogenase; Provisional; Region: PRK07574 1123523000558 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1123523000559 dimerization interface [polypeptide binding]; other site 1123523000560 ligand binding site [chemical binding]; other site 1123523000561 NAD binding site [chemical binding]; other site 1123523000562 catalytic site [active] 1123523000563 putative transporter; Provisional; Region: PRK10054 1123523000564 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1123523000565 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1123523000566 acyl-activating enzyme (AAE) consensus motif; other site 1123523000567 AMP binding site [chemical binding]; other site 1123523000568 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1123523000569 Condensation domain; Region: Condensation; pfam00668 1123523000570 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1123523000571 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1123523000572 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1123523000573 acyl-activating enzyme (AAE) consensus motif; other site 1123523000574 AMP binding site [chemical binding]; other site 1123523000575 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1123523000576 thioester reductase domain; Region: Thioester-redct; TIGR01746 1123523000577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1123523000578 NAD(P) binding site [chemical binding]; other site 1123523000579 active site 1123523000580 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1123523000581 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1123523000582 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1123523000583 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1123523000584 nucleotide binding site [chemical binding]; other site 1123523000585 N-acetyl-L-glutamate binding site [chemical binding]; other site 1123523000586 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1123523000587 heterotetramer interface [polypeptide binding]; other site 1123523000588 active site pocket [active] 1123523000589 cleavage site 1123523000590 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1123523000591 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1123523000592 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1123523000593 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1123523000594 inhibitor-cofactor binding pocket; inhibition site 1123523000595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523000596 catalytic residue [active] 1123523000597 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1123523000598 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1123523000599 Isochorismatase family; Region: Isochorismatase; pfam00857 1123523000600 catalytic triad [active] 1123523000601 conserved cis-peptide bond; other site 1123523000602 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1123523000603 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1123523000604 dimer interface [polypeptide binding]; other site 1123523000605 PYR/PP interface [polypeptide binding]; other site 1123523000606 TPP binding site [chemical binding]; other site 1123523000607 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1123523000608 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1123523000609 TPP-binding site [chemical binding]; other site 1123523000610 dimer interface [polypeptide binding]; other site 1123523000611 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1123523000612 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1123523000613 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1123523000614 active site turn [active] 1123523000615 phosphorylation site [posttranslational modification] 1123523000616 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1123523000617 HPr interaction site; other site 1123523000618 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1123523000619 active site 1123523000620 phosphorylation site [posttranslational modification] 1123523000621 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1123523000622 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1123523000623 Predicted sugar phosphate isomerase [General function prediction only]; Region: COG2103 1123523000624 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1123523000625 putative active site [active] 1123523000626 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1123523000627 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1123523000628 active site turn [active] 1123523000629 phosphorylation site [posttranslational modification] 1123523000630 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1123523000631 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1123523000632 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1123523000633 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1123523000634 putative active site [active] 1123523000635 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1123523000636 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1123523000637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523000638 ATP binding site [chemical binding]; other site 1123523000639 putative Mg++ binding site [ion binding]; other site 1123523000640 RES domain; Region: RES; pfam08808 1123523000641 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1123523000642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523000643 Walker A/P-loop; other site 1123523000644 ATP binding site [chemical binding]; other site 1123523000645 Q-loop/lid; other site 1123523000646 ABC transporter signature motif; other site 1123523000647 Walker B; other site 1123523000648 D-loop; other site 1123523000649 H-loop/switch region; other site 1123523000650 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1123523000651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523000652 Walker A/P-loop; other site 1123523000653 ATP binding site [chemical binding]; other site 1123523000654 Q-loop/lid; other site 1123523000655 ABC transporter signature motif; other site 1123523000656 Walker B; other site 1123523000657 D-loop; other site 1123523000658 H-loop/switch region; other site 1123523000659 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1123523000660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523000661 dimer interface [polypeptide binding]; other site 1123523000662 conserved gate region; other site 1123523000663 putative PBP binding loops; other site 1123523000664 ABC-ATPase subunit interface; other site 1123523000665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1123523000666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523000667 dimer interface [polypeptide binding]; other site 1123523000668 conserved gate region; other site 1123523000669 ABC-ATPase subunit interface; other site 1123523000670 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1123523000671 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1123523000672 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1123523000673 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1123523000674 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1123523000675 Staphylococcus tandem lipoproteins; Region: SA_tandem_lipo; TIGR01742 1123523000676 azoreductase; Reviewed; Region: PRK00170 1123523000677 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1123523000678 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1123523000679 Peptidase family M23; Region: Peptidase_M23; pfam01551 1123523000680 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1123523000681 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1123523000682 Walker A/P-loop; other site 1123523000683 ATP binding site [chemical binding]; other site 1123523000684 Q-loop/lid; other site 1123523000685 ABC transporter signature motif; other site 1123523000686 Walker B; other site 1123523000687 D-loop; other site 1123523000688 H-loop/switch region; other site 1123523000689 TOBE domain; Region: TOBE; pfam03459 1123523000690 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1123523000691 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1123523000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523000693 dimer interface [polypeptide binding]; other site 1123523000694 conserved gate region; other site 1123523000695 ABC-ATPase subunit interface; other site 1123523000696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1123523000697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523000698 dimer interface [polypeptide binding]; other site 1123523000699 conserved gate region; other site 1123523000700 putative PBP binding loops; other site 1123523000701 ABC-ATPase subunit interface; other site 1123523000702 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1123523000703 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1123523000704 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1123523000705 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1123523000706 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1123523000707 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1123523000708 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1123523000709 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1123523000710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1123523000711 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1123523000712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523000713 putative substrate translocation pore; other site 1123523000714 Response regulator receiver domain; Region: Response_reg; pfam00072 1123523000715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523000716 active site 1123523000717 phosphorylation site [posttranslational modification] 1123523000718 intermolecular recognition site; other site 1123523000719 dimerization interface [polypeptide binding]; other site 1123523000720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1123523000721 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1123523000722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1123523000723 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1123523000724 Histidine kinase; Region: His_kinase; pfam06580 1123523000725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523000726 ATP binding site [chemical binding]; other site 1123523000727 Mg2+ binding site [ion binding]; other site 1123523000728 G-X-G motif; other site 1123523000729 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1123523000730 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1123523000731 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1123523000732 Pyruvate formate lyase 1; Region: PFL1; cd01678 1123523000733 coenzyme A binding site [chemical binding]; other site 1123523000734 active site 1123523000735 catalytic residues [active] 1123523000736 glycine loop; other site 1123523000737 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1123523000738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523000739 FeS/SAM binding site; other site 1123523000740 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1123523000741 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1123523000742 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1123523000743 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1123523000744 putative active site [active] 1123523000745 catalytic site [active] 1123523000746 putative metal binding site [ion binding]; other site 1123523000747 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1123523000748 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1123523000749 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1123523000750 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1123523000751 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1123523000752 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1123523000753 Staphylocoagulase repeat; Region: Staphylcoagulse; pfam04022 1123523000754 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1123523000755 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1123523000756 dimer interface [polypeptide binding]; other site 1123523000757 active site 1123523000758 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1123523000759 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1123523000760 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1123523000761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1123523000762 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1123523000763 substrate binding site [chemical binding]; other site 1123523000764 oxyanion hole (OAH) forming residues; other site 1123523000765 trimer interface [polypeptide binding]; other site 1123523000766 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1123523000767 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1123523000768 active site 1123523000769 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1123523000770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1123523000771 acyl-activating enzyme (AAE) consensus motif; other site 1123523000772 AMP binding site [chemical binding]; other site 1123523000773 active site 1123523000774 CoA binding site [chemical binding]; other site 1123523000775 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1123523000776 Coenzyme A transferase; Region: CoA_trans; smart00882 1123523000777 Coenzyme A transferase; Region: CoA_trans; cl17247 1123523000778 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1123523000779 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1123523000780 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1123523000781 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1123523000782 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1123523000783 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1123523000784 heme-binding site [chemical binding]; other site 1123523000785 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1123523000786 FAD binding pocket [chemical binding]; other site 1123523000787 FAD binding motif [chemical binding]; other site 1123523000788 phosphate binding motif [ion binding]; other site 1123523000789 beta-alpha-beta structure motif; other site 1123523000790 NAD binding pocket [chemical binding]; other site 1123523000791 Heme binding pocket [chemical binding]; other site 1123523000792 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1123523000793 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1123523000794 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1123523000795 NAD binding site [chemical binding]; other site 1123523000796 dimer interface [polypeptide binding]; other site 1123523000797 substrate binding site [chemical binding]; other site 1123523000798 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1123523000799 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1123523000800 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1123523000801 active site turn [active] 1123523000802 phosphorylation site [posttranslational modification] 1123523000803 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1123523000804 active site 1123523000805 tetramer interface [polypeptide binding]; other site 1123523000806 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1123523000807 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1123523000808 Mga helix-turn-helix domain; Region: Mga; pfam05043 1123523000809 PRD domain; Region: PRD; pfam00874 1123523000810 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1123523000811 active site 1123523000812 P-loop; other site 1123523000813 phosphorylation site [posttranslational modification] 1123523000814 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1123523000815 active site 1123523000816 phosphorylation site [posttranslational modification] 1123523000817 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1123523000818 active site 1123523000819 phosphorylation site [posttranslational modification] 1123523000820 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1123523000821 active site 1123523000822 P-loop; other site 1123523000823 phosphorylation site [posttranslational modification] 1123523000824 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1123523000825 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1123523000826 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1123523000827 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1123523000828 putative NAD(P) binding site [chemical binding]; other site 1123523000829 catalytic Zn binding site [ion binding]; other site 1123523000830 structural Zn binding site [ion binding]; other site 1123523000831 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1123523000832 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1123523000833 putative NAD(P) binding site [chemical binding]; other site 1123523000834 catalytic Zn binding site [ion binding]; other site 1123523000835 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1123523000836 substrate binding site; other site 1123523000837 dimer interface; other site 1123523000838 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1123523000839 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1123523000840 putative NAD(P) binding site [chemical binding]; other site 1123523000841 putative catalytic Zn binding site [ion binding]; other site 1123523000842 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1123523000843 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1123523000844 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1123523000845 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1123523000846 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1123523000847 substrate binding site; other site 1123523000848 dimer interface; other site 1123523000849 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1123523000850 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1123523000851 putative NAD(P) binding site [chemical binding]; other site 1123523000852 putative catalytic Zn binding site [ion binding]; other site 1123523000853 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1123523000854 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1123523000855 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1123523000856 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1123523000857 active site 1123523000858 cell wall biosynthesis protein ScdA; Provisional; Region: PRK13276 1123523000859 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1123523000860 Hemerythrin-like domain; Region: Hr-like; cd12108 1123523000861 Fe binding site [ion binding]; other site 1123523000862 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1123523000863 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1123523000864 Histidine kinase; Region: His_kinase; pfam06580 1123523000865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523000866 Mg2+ binding site [ion binding]; other site 1123523000867 G-X-G motif; other site 1123523000868 two-component response regulator; Provisional; Region: PRK14084 1123523000869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523000870 active site 1123523000871 phosphorylation site [posttranslational modification] 1123523000872 intermolecular recognition site; other site 1123523000873 dimerization interface [polypeptide binding]; other site 1123523000874 LytTr DNA-binding domain; Region: LytTR; pfam04397 1123523000875 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1123523000876 antiholin-like protein LrgB; Provisional; Region: PRK04288 1123523000877 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1123523000878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1123523000879 DNA-binding site [nucleotide binding]; DNA binding site 1123523000880 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1123523000881 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1123523000882 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1123523000883 HPr interaction site; other site 1123523000884 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1123523000885 active site 1123523000886 phosphorylation site [posttranslational modification] 1123523000887 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1123523000888 beta-galactosidase; Region: BGL; TIGR03356 1123523000889 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1123523000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523000891 S-adenosylmethionine binding site [chemical binding]; other site 1123523000892 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1123523000893 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1123523000894 substrate binding site [chemical binding]; other site 1123523000895 dimer interface [polypeptide binding]; other site 1123523000896 ATP binding site [chemical binding]; other site 1123523000897 D-ribose pyranase; Provisional; Region: PRK11797 1123523000898 Sugar transport protein; Region: Sugar_transport; pfam06800 1123523000899 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1123523000900 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1123523000901 DNA binding site [nucleotide binding] 1123523000902 domain linker motif; other site 1123523000903 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1123523000904 dimerization interface [polypeptide binding]; other site 1123523000905 ligand binding site [chemical binding]; other site 1123523000906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1123523000907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523000908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523000909 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1123523000910 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1123523000911 active site 1123523000912 Surface antigen [General function prediction only]; Region: COG3942 1123523000913 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1123523000914 Peptidase family M23; Region: Peptidase_M23; pfam01551 1123523000915 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1123523000916 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1123523000917 Walker A/P-loop; other site 1123523000918 ATP binding site [chemical binding]; other site 1123523000919 Q-loop/lid; other site 1123523000920 ABC transporter signature motif; other site 1123523000921 Walker B; other site 1123523000922 D-loop; other site 1123523000923 H-loop/switch region; other site 1123523000924 Surface antigen [General function prediction only]; Region: COG3942 1123523000925 CHAP domain; Region: CHAP; pfam05257 1123523000926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1123523000927 Predicted membrane protein [Function unknown]; Region: COG1511 1123523000928 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1123523000929 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1123523000930 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1123523000931 Uncharacterized small protein [Function unknown]; Region: COG5417 1123523000932 Predicted membrane protein [Function unknown]; Region: COG4499 1123523000933 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1123523000934 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1123523000935 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1123523000936 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1123523000937 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1123523000938 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1123523000939 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1123523000940 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1123523000941 Protein of unknown function, DUF600; Region: DUF600; cl04640 1123523000942 Protein of unknown function, DUF600; Region: DUF600; cl04640 1123523000943 conserved hypothetical protein; Region: staph_tand_hypo; TIGR01741 1123523000944 Protein of unknown function, DUF600; Region: DUF600; cl04640 1123523000945 Protein of unknown function, DUF600; Region: DUF600; cl04640 1123523000946 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1123523000947 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1123523000948 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1123523000949 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 1123523000950 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1123523000951 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1123523000952 FtsX-like permease family; Region: FtsX; pfam02687 1123523000953 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1123523000954 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1123523000955 Walker A/P-loop; other site 1123523000956 ATP binding site [chemical binding]; other site 1123523000957 Q-loop/lid; other site 1123523000958 ABC transporter signature motif; other site 1123523000959 Walker B; other site 1123523000960 D-loop; other site 1123523000961 H-loop/switch region; other site 1123523000962 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1123523000963 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1123523000964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523000965 non-specific DNA binding site [nucleotide binding]; other site 1123523000966 salt bridge; other site 1123523000967 sequence-specific DNA binding site [nucleotide binding]; other site 1123523000968 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1123523000969 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1123523000970 substrate binding site [chemical binding]; other site 1123523000971 ATP binding site [chemical binding]; other site 1123523000972 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1123523000973 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1123523000974 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1123523000975 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1123523000976 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1123523000977 putative transporter; Provisional; Region: PRK10484 1123523000978 Na binding site [ion binding]; other site 1123523000979 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1123523000980 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1123523000981 inhibitor site; inhibition site 1123523000982 active site 1123523000983 dimer interface [polypeptide binding]; other site 1123523000984 catalytic residue [active] 1123523000985 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1123523000986 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1123523000987 nucleotide binding site [chemical binding]; other site 1123523000988 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1123523000989 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1123523000990 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1123523000991 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1123523000992 putative active site [active] 1123523000993 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1123523000994 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1123523000995 putative active site cavity [active] 1123523000996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1123523000997 Nucleoside recognition; Region: Gate; pfam07670 1123523000998 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1123523000999 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1123523001000 PGAP1-like protein; Region: PGAP1; pfam07819 1123523001001 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1123523001002 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1123523001003 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1123523001004 putative active site [active] 1123523001005 putative FMN binding site [chemical binding]; other site 1123523001006 putative substrate binding site [chemical binding]; other site 1123523001007 putative catalytic residue [active] 1123523001008 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1123523001009 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1123523001010 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1123523001011 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1123523001012 lipoyl attachment site [posttranslational modification]; other site 1123523001013 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1123523001014 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 1123523001015 putative ADP-ribose binding site [chemical binding]; other site 1123523001016 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1123523001017 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1123523001018 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1123523001019 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1123523001020 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1123523001021 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1123523001022 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1123523001023 NADP binding site [chemical binding]; other site 1123523001024 putative substrate binding site [chemical binding]; other site 1123523001025 active site 1123523001026 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1123523001027 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1123523001028 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1123523001029 active site 1123523001030 phosphorylation site [posttranslational modification] 1123523001031 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1123523001032 HTH domain; Region: HTH_11; pfam08279 1123523001033 HTH domain; Region: HTH_11; pfam08279 1123523001034 PRD domain; Region: PRD; pfam00874 1123523001035 PRD domain; Region: PRD; pfam00874 1123523001036 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1123523001037 active site 1123523001038 P-loop; other site 1123523001039 phosphorylation site [posttranslational modification] 1123523001040 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1123523001041 active site 1123523001042 phosphorylation site [posttranslational modification] 1123523001043 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1123523001044 MarR family; Region: MarR_2; pfam12802 1123523001045 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1123523001046 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1123523001047 MepB protein; Region: MepB; cl01985 1123523001048 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1123523001049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523001050 putative substrate translocation pore; other site 1123523001051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523001052 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1123523001053 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1123523001054 Zn binding site [ion binding]; other site 1123523001055 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1123523001056 Zn binding site [ion binding]; other site 1123523001057 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1123523001058 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1123523001059 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1123523001060 Predicted flavoprotein [General function prediction only]; Region: COG0431 1123523001061 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1123523001062 Predicted membrane protein [Function unknown]; Region: COG2855 1123523001063 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1123523001064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1123523001065 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1123523001066 Imelysin; Region: Peptidase_M75; pfam09375 1123523001067 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1123523001068 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1123523001069 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1123523001070 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1123523001071 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1123523001072 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1123523001073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523001074 non-specific DNA binding site [nucleotide binding]; other site 1123523001075 salt bridge; other site 1123523001076 sequence-specific DNA binding site [nucleotide binding]; other site 1123523001077 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1123523001078 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1123523001079 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1123523001080 Walker A/P-loop; other site 1123523001081 ATP binding site [chemical binding]; other site 1123523001082 Q-loop/lid; other site 1123523001083 ABC transporter signature motif; other site 1123523001084 Walker B; other site 1123523001085 D-loop; other site 1123523001086 H-loop/switch region; other site 1123523001087 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1123523001088 Predicted membrane protein [Function unknown]; Region: COG4292 1123523001089 putative acyltransferase; Provisional; Region: PRK05790 1123523001090 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1123523001091 dimer interface [polypeptide binding]; other site 1123523001092 active site 1123523001093 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1123523001094 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1123523001095 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1123523001096 THF binding site; other site 1123523001097 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1123523001098 substrate binding site [chemical binding]; other site 1123523001099 THF binding site; other site 1123523001100 zinc-binding site [ion binding]; other site 1123523001101 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1123523001102 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1123523001103 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1123523001104 FAD binding site [chemical binding]; other site 1123523001105 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1123523001106 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1123523001107 homodimer interface [polypeptide binding]; other site 1123523001108 substrate-cofactor binding pocket; other site 1123523001109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523001110 catalytic residue [active] 1123523001111 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1123523001112 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1123523001113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1123523001114 catalytic residue [active] 1123523001115 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1123523001116 ParB-like nuclease domain; Region: ParB; smart00470 1123523001117 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1123523001118 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1123523001119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 1123523001120 GTP-binding protein YchF; Reviewed; Region: PRK09601 1123523001121 YchF GTPase; Region: YchF; cd01900 1123523001122 G1 box; other site 1123523001123 GTP/Mg2+ binding site [chemical binding]; other site 1123523001124 Switch I region; other site 1123523001125 G2 box; other site 1123523001126 Switch II region; other site 1123523001127 G3 box; other site 1123523001128 G4 box; other site 1123523001129 G5 box; other site 1123523001130 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1123523001131 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1123523001132 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1123523001133 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1123523001134 dimer interface [polypeptide binding]; other site 1123523001135 ssDNA binding site [nucleotide binding]; other site 1123523001136 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1123523001137 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1123523001138 Abi-like protein; Region: Abi_2; pfam07751 1123523001139 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1123523001140 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1123523001142 Predicted membrane protein [Function unknown]; Region: COG3212 1123523001143 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1123523001144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1123523001145 non-specific DNA binding site [nucleotide binding]; other site 1123523001146 salt bridge; other site 1123523001147 sequence-specific DNA binding site [nucleotide binding]; other site 1123523001148 Predicted membrane protein [Function unknown]; Region: COG2261 1123523001149 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1123523001150 catalytic core [active] 1123523001151 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1123523001152 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1123523001153 catalytic residue [active] 1123523001154 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1123523001155 catalytic residues [active] 1123523001156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1123523001157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523001158 peroxiredoxin; Region: AhpC; TIGR03137 1123523001159 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1123523001160 dimer interface [polypeptide binding]; other site 1123523001161 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1123523001162 catalytic triad [active] 1123523001163 peroxidatic and resolving cysteines [active] 1123523001164 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1123523001165 dimer interface [polypeptide binding]; other site 1123523001166 FMN binding site [chemical binding]; other site 1123523001167 NADPH bind site [chemical binding]; other site 1123523001168 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1123523001169 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1123523001170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1123523001171 active site 1123523001172 xanthine permease; Region: pbuX; TIGR03173 1123523001173 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1123523001174 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1123523001175 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1123523001176 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1123523001177 active site 1123523001178 GMP synthase; Reviewed; Region: guaA; PRK00074 1123523001179 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1123523001180 AMP/PPi binding site [chemical binding]; other site 1123523001181 candidate oxyanion hole; other site 1123523001182 catalytic triad [active] 1123523001183 potential glutamine specificity residues [chemical binding]; other site 1123523001184 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1123523001185 ATP Binding subdomain [chemical binding]; other site 1123523001186 Ligand Binding sites [chemical binding]; other site 1123523001187 Dimerization subdomain; other site 1123523001188 Abi-like protein; Region: Abi_2; pfam07751 1123523001189 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1123523001190 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1123523001191 LabA_like proteins; Region: LabA_like; cd06167 1123523001192 putative metal binding site [ion binding]; other site 1123523001193 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1123523001194 Predicted membrane protein [Function unknown]; Region: COG3759 1123523001195 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1123523001196 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1123523001197 NADP binding site [chemical binding]; other site 1123523001198 superantigen-like protein; Reviewed; Region: PRK13037 1123523001199 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001200 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001201 superantigen-like protein; Reviewed; Region: PRK13041 1123523001202 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001203 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001204 superantigen-like protein; Reviewed; Region: PRK13335 1123523001205 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001206 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001207 superantigen-like protein; Reviewed; Region: PRK13041 1123523001208 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001209 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001210 superantigen-like protein 5; Reviewed; Region: PRK13035 1123523001211 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001212 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001213 superantigen-like protein 7; Reviewed; Region: PRK13346 1123523001214 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001215 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001216 superantigen-like protein; Reviewed; Region: PRK13039 1123523001217 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001218 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001219 superantigen-like protein; Reviewed; Region: PRK13345 1123523001220 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001221 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001222 superantigen-like protein 5; Reviewed; Region: PRK13035 1123523001223 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001224 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001225 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1123523001226 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1123523001227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523001228 S-adenosylmethionine binding site [chemical binding]; other site 1123523001229 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1123523001230 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1123523001231 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1123523001232 superantigen-like protein; Reviewed; Region: PRK13036 1123523001233 Domain of unknown function (DUF1954); Region: DUF1954; pfam09199 1123523001234 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523001235 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523001236 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523001237 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523001238 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523001239 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523001240 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523001241 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523001242 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523001243 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523001244 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1123523001245 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1123523001246 nucleophilic elbow; other site 1123523001247 catalytic triad; other site 1123523001248 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1123523001249 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1123523001250 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1123523001251 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1123523001252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1123523001253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1123523001254 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1123523001255 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 1123523001256 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1123523001257 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1123523001258 active site 1123523001259 Esterase/lipase [General function prediction only]; Region: COG1647 1123523001260 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1123523001261 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1123523001262 Na2 binding site [ion binding]; other site 1123523001263 putative substrate binding site 1 [chemical binding]; other site 1123523001264 Na binding site 1 [ion binding]; other site 1123523001265 putative substrate binding site 2 [chemical binding]; other site 1123523001266 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1123523001267 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1123523001268 dimer interface [polypeptide binding]; other site 1123523001269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523001270 catalytic residue [active] 1123523001271 cystathionine beta-lyase; Provisional; Region: PRK07671 1123523001272 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1123523001273 homodimer interface [polypeptide binding]; other site 1123523001274 substrate-cofactor binding pocket; other site 1123523001275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523001276 catalytic residue [active] 1123523001277 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1123523001278 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1123523001279 Walker A/P-loop; other site 1123523001280 ATP binding site [chemical binding]; other site 1123523001281 Q-loop/lid; other site 1123523001282 ABC transporter signature motif; other site 1123523001283 Walker B; other site 1123523001284 D-loop; other site 1123523001285 H-loop/switch region; other site 1123523001286 NIL domain; Region: NIL; pfam09383 1123523001287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523001288 dimer interface [polypeptide binding]; other site 1123523001289 conserved gate region; other site 1123523001290 ABC-ATPase subunit interface; other site 1123523001291 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1123523001292 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1123523001293 LysM domain; Region: LysM; pfam01476 1123523001294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1123523001295 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1123523001296 Surface antigen [General function prediction only]; Region: COG3942 1123523001297 CHAP domain; Region: CHAP; pfam05257 1123523001298 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1123523001299 nudix motif; other site 1123523001300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523001301 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1123523001302 Coenzyme A binding pocket [chemical binding]; other site 1123523001303 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1123523001304 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 1123523001305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1123523001306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1123523001307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1123523001308 dimerization interface [polypeptide binding]; other site 1123523001309 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1123523001310 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1123523001311 active site 1123523001312 dimer interface [polypeptide binding]; other site 1123523001313 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1123523001314 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1123523001315 active site 1123523001316 FMN binding site [chemical binding]; other site 1123523001317 substrate binding site [chemical binding]; other site 1123523001318 3Fe-4S cluster binding site [ion binding]; other site 1123523001319 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1123523001320 domain interface; other site 1123523001321 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1123523001322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1123523001323 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1123523001324 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1123523001325 active site turn [active] 1123523001326 phosphorylation site [posttranslational modification] 1123523001327 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1123523001328 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1123523001329 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1123523001330 Ca binding site [ion binding]; other site 1123523001331 active site 1123523001332 catalytic site [active] 1123523001333 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1123523001334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1123523001335 DNA-binding site [nucleotide binding]; DNA binding site 1123523001336 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1123523001337 UTRA domain; Region: UTRA; pfam07702 1123523001338 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1123523001339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523001340 Coenzyme A binding pocket [chemical binding]; other site 1123523001341 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1123523001342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523001343 Walker A motif; other site 1123523001344 ATP binding site [chemical binding]; other site 1123523001345 Walker B motif; other site 1123523001346 arginine finger; other site 1123523001347 hypothetical protein; Validated; Region: PRK00153 1123523001348 recombination protein RecR; Reviewed; Region: recR; PRK00076 1123523001349 RecR protein; Region: RecR; pfam02132 1123523001350 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1123523001351 putative active site [active] 1123523001352 putative metal-binding site [ion binding]; other site 1123523001353 tetramer interface [polypeptide binding]; other site 1123523001354 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1123523001355 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1123523001356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1123523001357 catalytic residue [active] 1123523001358 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1123523001359 thymidylate kinase; Validated; Region: tmk; PRK00698 1123523001360 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1123523001361 TMP-binding site; other site 1123523001362 ATP-binding site [chemical binding]; other site 1123523001363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 1123523001364 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1123523001365 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1123523001366 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1123523001367 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1123523001368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523001369 S-adenosylmethionine binding site [chemical binding]; other site 1123523001370 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1123523001371 GIY-YIG motif/motif A; other site 1123523001372 putative active site [active] 1123523001373 putative metal binding site [ion binding]; other site 1123523001374 Predicted methyltransferases [General function prediction only]; Region: COG0313 1123523001375 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1123523001376 putative SAM binding site [chemical binding]; other site 1123523001377 putative homodimer interface [polypeptide binding]; other site 1123523001378 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1123523001379 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1123523001380 active site 1123523001381 HIGH motif; other site 1123523001382 KMSKS motif; other site 1123523001383 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1123523001384 tRNA binding surface [nucleotide binding]; other site 1123523001385 anticodon binding site; other site 1123523001386 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1123523001387 dimer interface [polypeptide binding]; other site 1123523001388 putative tRNA-binding site [nucleotide binding]; other site 1123523001389 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1123523001390 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1123523001391 active site 1123523001392 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1123523001393 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1123523001394 putative active site [active] 1123523001395 putative metal binding site [ion binding]; other site 1123523001396 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1123523001397 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1123523001398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523001399 S-adenosylmethionine binding site [chemical binding]; other site 1123523001400 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1123523001401 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1123523001402 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1123523001403 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1123523001404 pur operon repressor; Provisional; Region: PRK09213 1123523001405 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1123523001406 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1123523001407 active site 1123523001408 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1123523001409 homotrimer interaction site [polypeptide binding]; other site 1123523001410 putative active site [active] 1123523001411 regulatory protein SpoVG; Reviewed; Region: PRK13259 1123523001412 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1123523001413 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1123523001414 Substrate binding site; other site 1123523001415 Mg++ binding site; other site 1123523001416 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1123523001417 active site 1123523001418 substrate binding site [chemical binding]; other site 1123523001419 CoA binding site [chemical binding]; other site 1123523001420 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1123523001421 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1123523001422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1123523001423 active site 1123523001424 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1123523001425 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1123523001426 5S rRNA interface [nucleotide binding]; other site 1123523001427 CTC domain interface [polypeptide binding]; other site 1123523001428 L16 interface [polypeptide binding]; other site 1123523001429 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1123523001430 putative active site [active] 1123523001431 catalytic residue [active] 1123523001432 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1123523001433 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1123523001434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523001435 ATP binding site [chemical binding]; other site 1123523001436 putative Mg++ binding site [ion binding]; other site 1123523001437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1123523001438 nucleotide binding region [chemical binding]; other site 1123523001439 ATP-binding site [chemical binding]; other site 1123523001440 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1123523001441 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1123523001442 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1123523001443 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1123523001444 putative SAM binding site [chemical binding]; other site 1123523001445 putative homodimer interface [polypeptide binding]; other site 1123523001446 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1123523001447 homodimer interface [polypeptide binding]; other site 1123523001448 metal binding site [ion binding]; metal-binding site 1123523001449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1123523001450 RNA binding surface [nucleotide binding]; other site 1123523001451 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1123523001452 Septum formation initiator; Region: DivIC; pfam04977 1123523001453 hypothetical protein; Provisional; Region: PRK08582 1123523001454 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1123523001455 RNA binding site [nucleotide binding]; other site 1123523001456 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1123523001457 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1123523001458 Ligand Binding Site [chemical binding]; other site 1123523001459 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1123523001460 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1123523001461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1123523001462 active site 1123523001463 FtsH Extracellular; Region: FtsH_ext; pfam06480 1123523001464 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1123523001465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523001466 Walker A motif; other site 1123523001467 ATP binding site [chemical binding]; other site 1123523001468 Walker B motif; other site 1123523001469 arginine finger; other site 1123523001470 Peptidase family M41; Region: Peptidase_M41; pfam01434 1123523001471 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1123523001472 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1123523001473 dimerization interface [polypeptide binding]; other site 1123523001474 domain crossover interface; other site 1123523001475 redox-dependent activation switch; other site 1123523001476 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1123523001477 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1123523001478 dimer interface [polypeptide binding]; other site 1123523001479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523001480 catalytic residue [active] 1123523001481 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1123523001482 dihydropteroate synthase; Region: DHPS; TIGR01496 1123523001483 substrate binding pocket [chemical binding]; other site 1123523001484 dimer interface [polypeptide binding]; other site 1123523001485 inhibitor binding site; inhibition site 1123523001486 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1123523001487 homooctamer interface [polypeptide binding]; other site 1123523001488 active site 1123523001489 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1123523001490 catalytic center binding site [active] 1123523001491 ATP binding site [chemical binding]; other site 1123523001492 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1123523001493 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1123523001494 dimer interface [polypeptide binding]; other site 1123523001495 putative anticodon binding site; other site 1123523001496 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1123523001497 motif 1; other site 1123523001498 active site 1123523001499 motif 2; other site 1123523001500 motif 3; other site 1123523001501 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1123523001502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1123523001503 DNA-binding site [nucleotide binding]; DNA binding site 1123523001504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1123523001505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523001506 homodimer interface [polypeptide binding]; other site 1123523001507 catalytic residue [active] 1123523001508 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1123523001509 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1123523001510 active site 1123523001511 multimer interface [polypeptide binding]; other site 1123523001512 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1123523001513 predicted active site [active] 1123523001514 catalytic triad [active] 1123523001515 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1123523001516 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1123523001517 Nucleoside recognition; Region: Gate; pfam07670 1123523001518 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1123523001519 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 1123523001520 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1123523001521 UvrB/uvrC motif; Region: UVR; pfam02151 1123523001522 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1123523001523 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1123523001524 ADP binding site [chemical binding]; other site 1123523001525 phosphagen binding site; other site 1123523001526 substrate specificity loop; other site 1123523001527 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1123523001528 Clp amino terminal domain; Region: Clp_N; pfam02861 1123523001529 Clp amino terminal domain; Region: Clp_N; pfam02861 1123523001530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523001531 Walker A motif; other site 1123523001532 ATP binding site [chemical binding]; other site 1123523001533 Walker B motif; other site 1123523001534 arginine finger; other site 1123523001535 UvrB/uvrC motif; Region: UVR; pfam02151 1123523001536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523001537 Walker A motif; other site 1123523001538 ATP binding site [chemical binding]; other site 1123523001539 Walker B motif; other site 1123523001540 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1123523001541 DNA repair protein RadA; Provisional; Region: PRK11823 1123523001542 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1123523001543 Walker A motif/ATP binding site; other site 1123523001544 ATP binding site [chemical binding]; other site 1123523001545 Walker B motif; other site 1123523001546 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1123523001547 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1123523001548 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1123523001549 putative active site [active] 1123523001550 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1123523001551 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1123523001552 active site 1123523001553 HIGH motif; other site 1123523001554 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1123523001555 active site 1123523001556 KMSKS motif; other site 1123523001557 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1123523001558 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1123523001559 trimer interface [polypeptide binding]; other site 1123523001560 active site 1123523001561 substrate binding site [chemical binding]; other site 1123523001562 CoA binding site [chemical binding]; other site 1123523001563 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1123523001564 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1123523001565 active site 1123523001566 HIGH motif; other site 1123523001567 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1123523001568 KMSKS motif; other site 1123523001569 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1123523001570 tRNA binding surface [nucleotide binding]; other site 1123523001571 anticodon binding site; other site 1123523001572 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1123523001573 active site 1123523001574 dimerization interface [polypeptide binding]; other site 1123523001575 metal binding site [ion binding]; metal-binding site 1123523001576 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1123523001577 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1123523001578 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1123523001579 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1123523001580 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1123523001581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1123523001582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1123523001583 DNA binding residues [nucleotide binding] 1123523001584 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1123523001585 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1123523001586 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1123523001587 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1123523001588 putative homodimer interface [polypeptide binding]; other site 1123523001589 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1123523001590 heterodimer interface [polypeptide binding]; other site 1123523001591 homodimer interface [polypeptide binding]; other site 1123523001592 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1123523001593 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1123523001594 23S rRNA interface [nucleotide binding]; other site 1123523001595 L7/L12 interface [polypeptide binding]; other site 1123523001596 putative thiostrepton binding site; other site 1123523001597 L25 interface [polypeptide binding]; other site 1123523001598 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1123523001599 mRNA/rRNA interface [nucleotide binding]; other site 1123523001600 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1123523001601 23S rRNA interface [nucleotide binding]; other site 1123523001602 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1123523001603 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1123523001604 peripheral dimer interface [polypeptide binding]; other site 1123523001605 core dimer interface [polypeptide binding]; other site 1123523001606 L10 interface [polypeptide binding]; other site 1123523001607 L11 interface [polypeptide binding]; other site 1123523001608 putative EF-Tu interaction site [polypeptide binding]; other site 1123523001609 putative EF-G interaction site [polypeptide binding]; other site 1123523001610 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1123523001611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523001612 S-adenosylmethionine binding site [chemical binding]; other site 1123523001613 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1123523001614 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1123523001615 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1123523001616 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1123523001617 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1123523001618 RPB10 interaction site [polypeptide binding]; other site 1123523001619 RPB1 interaction site [polypeptide binding]; other site 1123523001620 RPB11 interaction site [polypeptide binding]; other site 1123523001621 RPB3 interaction site [polypeptide binding]; other site 1123523001622 RPB12 interaction site [polypeptide binding]; other site 1123523001623 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1123523001624 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1123523001625 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1123523001626 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1123523001627 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1123523001628 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1123523001629 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1123523001630 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1123523001631 G-loop; other site 1123523001632 DNA binding site [nucleotide binding] 1123523001633 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13600 1123523001634 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1123523001635 S17 interaction site [polypeptide binding]; other site 1123523001636 S8 interaction site; other site 1123523001637 16S rRNA interaction site [nucleotide binding]; other site 1123523001638 streptomycin interaction site [chemical binding]; other site 1123523001639 23S rRNA interaction site [nucleotide binding]; other site 1123523001640 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1123523001641 30S ribosomal protein S7; Validated; Region: PRK05302 1123523001642 elongation factor G; Reviewed; Region: PRK00007 1123523001643 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1123523001644 G1 box; other site 1123523001645 putative GEF interaction site [polypeptide binding]; other site 1123523001646 GTP/Mg2+ binding site [chemical binding]; other site 1123523001647 Switch I region; other site 1123523001648 G2 box; other site 1123523001649 G3 box; other site 1123523001650 Switch II region; other site 1123523001651 G4 box; other site 1123523001652 G5 box; other site 1123523001653 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1123523001654 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1123523001655 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1123523001656 elongation factor Tu; Reviewed; Region: PRK00049 1123523001657 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1123523001658 G1 box; other site 1123523001659 GEF interaction site [polypeptide binding]; other site 1123523001660 GTP/Mg2+ binding site [chemical binding]; other site 1123523001661 Switch I region; other site 1123523001662 G2 box; other site 1123523001663 G3 box; other site 1123523001664 Switch II region; other site 1123523001665 G4 box; other site 1123523001666 G5 box; other site 1123523001667 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1123523001668 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1123523001669 Antibiotic Binding Site [chemical binding]; other site 1123523001670 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1123523001671 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1123523001672 metal binding site [ion binding]; metal-binding site 1123523001673 dimer interface [polypeptide binding]; other site 1123523001674 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1123523001675 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1123523001676 substrate-cofactor binding pocket; other site 1123523001677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523001678 catalytic residue [active] 1123523001679 chaperone protein HchA; Provisional; Region: PRK04155 1123523001680 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1123523001681 dimer interface [polypeptide binding]; other site 1123523001682 metal binding site [ion binding]; metal-binding site 1123523001683 potential oxyanion hole; other site 1123523001684 potential catalytic triad [active] 1123523001685 conserved cys residue [active] 1123523001686 ribulokinase; Provisional; Region: PRK04123 1123523001687 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1123523001688 N- and C-terminal domain interface [polypeptide binding]; other site 1123523001689 active site 1123523001690 MgATP binding site [chemical binding]; other site 1123523001691 catalytic site [active] 1123523001692 metal binding site [ion binding]; metal-binding site 1123523001693 carbohydrate binding site [chemical binding]; other site 1123523001694 homodimer interface [polypeptide binding]; other site 1123523001695 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1123523001696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1123523001697 NAD(P) binding site [chemical binding]; other site 1123523001698 active site 1123523001699 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1123523001700 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1123523001701 homodimer interface [polypeptide binding]; other site 1123523001702 substrate-cofactor binding pocket; other site 1123523001703 catalytic residue [active] 1123523001704 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1123523001705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523001706 motif II; other site 1123523001707 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1123523001708 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1123523001709 Substrate-binding site [chemical binding]; other site 1123523001710 Substrate specificity [chemical binding]; other site 1123523001711 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1123523001712 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1123523001713 Substrate-binding site [chemical binding]; other site 1123523001714 Substrate specificity [chemical binding]; other site 1123523001715 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1123523001716 nucleoside/Zn binding site; other site 1123523001717 dimer interface [polypeptide binding]; other site 1123523001718 catalytic motif [active] 1123523001719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523001720 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1123523001721 active site 1123523001722 motif I; other site 1123523001723 motif II; other site 1123523001724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523001725 Predicted flavoprotein [General function prediction only]; Region: COG0431 1123523001726 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1123523001727 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523001728 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1123523001729 Cna protein B-type domain; Region: Cna_B; pfam05738 1123523001730 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1123523001731 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523001732 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1123523001733 Cna protein B-type domain; Region: Cna_B; pfam05738 1123523001734 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1123523001735 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1123523001736 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1123523001737 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1123523001738 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523001739 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1123523001740 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1123523001741 Cna protein B-type domain; Region: Cna_B; pfam05738 1123523001742 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1123523001743 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1123523001744 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1123523001745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1123523001746 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1123523001747 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1123523001748 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1123523001749 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1123523001750 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1123523001751 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1123523001752 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1123523001753 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1123523001754 active site 1123523001755 trimer interface [polypeptide binding]; other site 1123523001756 allosteric site; other site 1123523001757 active site lid [active] 1123523001758 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1123523001759 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1123523001760 active site 1123523001761 dimer interface [polypeptide binding]; other site 1123523001762 magnesium binding site [ion binding]; other site 1123523001763 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1123523001764 tetramer interface [polypeptide binding]; other site 1123523001765 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1123523001766 active site 1123523001767 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1123523001768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523001769 motif II; other site 1123523001770 proline/glycine betaine transporter; Provisional; Region: PRK10642 1123523001771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523001772 putative substrate translocation pore; other site 1123523001773 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1123523001774 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1123523001775 acyl-activating enzyme (AAE) consensus motif; other site 1123523001776 AMP binding site [chemical binding]; other site 1123523001777 active site 1123523001778 CoA binding site [chemical binding]; other site 1123523001779 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1123523001780 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1123523001781 dimer interface [polypeptide binding]; other site 1123523001782 active site 1123523001783 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1123523001784 dimer interface [polypeptide binding]; other site 1123523001785 substrate binding site [chemical binding]; other site 1123523001786 ATP binding site [chemical binding]; other site 1123523001787 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1123523001788 ligand binding site [chemical binding]; other site 1123523001789 active site 1123523001790 UGI interface [polypeptide binding]; other site 1123523001791 catalytic site [active] 1123523001792 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1123523001793 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1123523001794 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1123523001795 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1123523001796 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1123523001797 putative heme peroxidase; Provisional; Region: PRK12276 1123523001798 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1123523001799 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1123523001800 mevalonate kinase; Region: mevalon_kin; TIGR00549 1123523001801 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1123523001802 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1123523001803 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1123523001804 diphosphomevalonate decarboxylase; Region: PLN02407 1123523001805 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1123523001806 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1123523001807 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1123523001808 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1123523001809 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1123523001810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523001811 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1123523001812 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1123523001813 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1123523001814 catalytic residues [active] 1123523001815 catalytic nucleophile [active] 1123523001816 Presynaptic Site I dimer interface [polypeptide binding]; other site 1123523001817 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1123523001818 Synaptic Flat tetramer interface [polypeptide binding]; other site 1123523001819 Synaptic Site I dimer interface [polypeptide binding]; other site 1123523001820 DNA binding site [nucleotide binding] 1123523001821 Recombinase; Region: Recombinase; pfam07508 1123523001822 PemK-like protein; Region: PemK; pfam02452 1123523001823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523001824 non-specific DNA binding site [nucleotide binding]; other site 1123523001825 salt bridge; other site 1123523001826 sequence-specific DNA binding site [nucleotide binding]; other site 1123523001827 Predicted transcriptional regulator [Transcription]; Region: COG2932 1123523001828 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1123523001829 Catalytic site [active] 1123523001830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523001831 non-specific DNA binding site [nucleotide binding]; other site 1123523001832 salt bridge; other site 1123523001833 sequence-specific DNA binding site [nucleotide binding]; other site 1123523001834 Prophage antirepressor [Transcription]; Region: COG3617 1123523001835 BRO family, N-terminal domain; Region: Bro-N; smart01040 1123523001836 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1123523001837 Protein of unknown function (DUF1270); Region: DUF1270; pfam06900 1123523001838 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1123523001839 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1123523001840 RecT family; Region: RecT; pfam03837 1123523001841 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1123523001842 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1123523001843 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1123523001844 dimer interface [polypeptide binding]; other site 1123523001845 ssDNA binding site [nucleotide binding]; other site 1123523001846 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1123523001847 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1123523001848 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1123523001849 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1123523001850 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1123523001851 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1123523001852 dUTPase; Region: dUTPase_2; pfam08761 1123523001853 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1123523001854 active site 1123523001855 homodimer interface [polypeptide binding]; other site 1123523001856 metal binding site [ion binding]; metal-binding site 1123523001857 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1123523001858 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1123523001859 Transcriptional activator RinB; Region: RinB; pfam06116 1123523001860 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1123523001861 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1123523001862 Terminase small subunit; Region: Terminase_2; pfam03592 1123523001863 phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547 1123523001864 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1123523001865 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1123523001866 phage putative head morphogenesis protein, SPP1 gp7 family; Region: phageSPP1_gp7; TIGR01641 1123523001867 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1123523001868 Phage capsid family; Region: Phage_capsid; pfam05065 1123523001869 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 1123523001870 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1123523001871 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 1123523001872 Phage protein; Region: DUF3647; pfam12363 1123523001873 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1123523001874 Phage-related protein [Function unknown]; Region: COG5412 1123523001875 membrane protein P6; Region: PHA01399 1123523001876 Phage tail protein; Region: Sipho_tail; pfam05709 1123523001877 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1123523001878 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1123523001879 active site 1123523001880 catalytic triad [active] 1123523001881 oxyanion hole [active] 1123523001882 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1123523001883 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 1123523001884 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1123523001885 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1123523001886 CHAP domain; Region: CHAP; pfam05257 1123523001887 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1123523001888 Lysozyme subfamily 2; Region: LYZ2; smart00047 1123523001889 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1123523001890 Phage tail repeat like; Region: PTR; pfam12789 1123523001891 Bacteriophage holin; Region: Phage_holin_1; pfam04531 1123523001892 CHAP domain; Region: CHAP; pfam05257 1123523001893 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1123523001894 amidase catalytic site [active] 1123523001895 Zn binding residues [ion binding]; other site 1123523001896 substrate binding site [chemical binding]; other site 1123523001897 Bacterial SH3 domain; Region: SH3_5; pfam08460 1123523001898 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1123523001899 Predicted transcriptional regulator [Transcription]; Region: COG1959 1123523001900 Transcriptional regulator; Region: Rrf2; pfam02082 1123523001901 LXG domain of WXG superfamily; Region: LXG; pfam04740 1123523001902 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1123523001903 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1123523001904 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1123523001905 Protein of unknown function (DUF443); Region: DUF443; pfam04276 1123523001906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1123523001907 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1123523001908 active site 1123523001909 catalytic tetrad [active] 1123523001910 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1123523001911 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1123523001912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1123523001913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523001914 Coenzyme A binding pocket [chemical binding]; other site 1123523001915 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1123523001916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1123523001917 Zn2+ binding site [ion binding]; other site 1123523001918 Mg2+ binding site [ion binding]; other site 1123523001919 YwhD family; Region: YwhD; pfam08741 1123523001920 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1123523001921 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1123523001922 NAD binding site [chemical binding]; other site 1123523001923 substrate binding site [chemical binding]; other site 1123523001924 catalytic Zn binding site [ion binding]; other site 1123523001925 tetramer interface [polypeptide binding]; other site 1123523001926 structural Zn binding site [ion binding]; other site 1123523001927 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1123523001928 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1123523001929 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1123523001930 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1123523001931 active site 1123523001932 HIGH motif; other site 1123523001933 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1123523001934 KMSK motif region; other site 1123523001935 tRNA binding surface [nucleotide binding]; other site 1123523001936 DALR anticodon binding domain; Region: DALR_1; smart00836 1123523001937 anticodon binding site; other site 1123523001938 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1123523001939 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1123523001940 minor groove reading motif; other site 1123523001941 helix-hairpin-helix signature motif; other site 1123523001942 substrate binding pocket [chemical binding]; other site 1123523001943 active site 1123523001944 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1123523001945 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1123523001946 putative binding site residues; other site 1123523001947 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1123523001948 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523001949 ABC-ATPase subunit interface; other site 1123523001950 dimer interface [polypeptide binding]; other site 1123523001951 putative PBP binding regions; other site 1123523001952 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1123523001953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523001954 motif II; other site 1123523001955 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1123523001956 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1123523001957 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1123523001958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1123523001959 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523001960 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1123523001961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1123523001962 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1123523001963 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1123523001964 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1123523001965 active site 1123523001966 DNA binding site [nucleotide binding] 1123523001967 Int/Topo IB signature motif; other site 1123523001968 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 1123523001969 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1123523001970 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1123523001971 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12574 1123523001972 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12660 1123523001973 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 1123523001974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1123523001975 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1123523001976 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12657 1123523001977 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1123523001978 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1123523001979 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1123523001980 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1123523001981 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1123523001982 metal binding site [ion binding]; metal-binding site 1123523001983 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1123523001984 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523001985 ABC-ATPase subunit interface; other site 1123523001986 dimer interface [polypeptide binding]; other site 1123523001987 putative PBP binding regions; other site 1123523001988 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1123523001989 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1123523001990 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1123523001991 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1123523001992 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1123523001993 FeoA domain; Region: FeoA; pfam04023 1123523001994 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1123523001995 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1123523001996 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1123523001997 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 1123523001998 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1123523001999 Walker A/P-loop; other site 1123523002000 ATP binding site [chemical binding]; other site 1123523002001 Q-loop/lid; other site 1123523002002 ABC transporter signature motif; other site 1123523002003 Walker B; other site 1123523002004 D-loop; other site 1123523002005 H-loop/switch region; other site 1123523002006 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1123523002007 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1123523002008 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1123523002009 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1123523002010 active site 1123523002011 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1123523002012 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1123523002013 active site 1123523002014 nucleotide binding site [chemical binding]; other site 1123523002015 HIGH motif; other site 1123523002016 KMSKS motif; other site 1123523002017 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1123523002018 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1123523002019 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1123523002020 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1123523002021 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1123523002022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523002023 Walker A/P-loop; other site 1123523002024 ATP binding site [chemical binding]; other site 1123523002025 Q-loop/lid; other site 1123523002026 ABC transporter signature motif; other site 1123523002027 Walker B; other site 1123523002028 D-loop; other site 1123523002029 H-loop/switch region; other site 1123523002030 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1123523002031 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1123523002032 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1123523002033 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1123523002034 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1123523002035 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1123523002036 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1123523002037 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1123523002038 Walker A/P-loop; other site 1123523002039 ATP binding site [chemical binding]; other site 1123523002040 Q-loop/lid; other site 1123523002041 ABC transporter signature motif; other site 1123523002042 Walker B; other site 1123523002043 D-loop; other site 1123523002044 H-loop/switch region; other site 1123523002045 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1123523002046 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523002047 ABC-ATPase subunit interface; other site 1123523002048 dimer interface [polypeptide binding]; other site 1123523002049 putative PBP binding regions; other site 1123523002050 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1123523002051 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523002052 ABC-ATPase subunit interface; other site 1123523002053 dimer interface [polypeptide binding]; other site 1123523002054 putative PBP binding regions; other site 1123523002055 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1123523002056 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1123523002057 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1123523002058 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1123523002059 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1123523002060 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1123523002061 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1123523002062 Na binding site [ion binding]; other site 1123523002063 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1123523002064 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1123523002065 substrate binding pocket [chemical binding]; other site 1123523002066 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1123523002067 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1123523002068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523002069 Coenzyme A binding pocket [chemical binding]; other site 1123523002070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1123523002071 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1123523002072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1123523002073 NAD(P) binding site [chemical binding]; other site 1123523002074 active site 1123523002075 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523002076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523002077 active site 1123523002078 phosphorylation site [posttranslational modification] 1123523002079 intermolecular recognition site; other site 1123523002080 dimerization interface [polypeptide binding]; other site 1123523002081 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523002082 DNA binding site [nucleotide binding] 1123523002083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1123523002084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1123523002085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523002086 ATP binding site [chemical binding]; other site 1123523002087 Mg2+ binding site [ion binding]; other site 1123523002088 G-X-G motif; other site 1123523002089 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1123523002090 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1123523002091 Walker A/P-loop; other site 1123523002092 ATP binding site [chemical binding]; other site 1123523002093 Q-loop/lid; other site 1123523002094 ABC transporter signature motif; other site 1123523002095 Walker B; other site 1123523002096 D-loop; other site 1123523002097 H-loop/switch region; other site 1123523002098 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1123523002099 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1123523002100 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1123523002101 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1123523002102 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1123523002103 Surface antigen [General function prediction only]; Region: COG3942 1123523002104 CHAP domain; Region: CHAP; pfam05257 1123523002105 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1123523002106 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1123523002107 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1123523002108 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523002109 hypothetical protein; Provisional; Region: PRK12378 1123523002110 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1123523002111 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1123523002112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1123523002113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1123523002114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1123523002115 dimerization interface [polypeptide binding]; other site 1123523002116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523002117 sugar efflux transporter; Region: 2A0120; TIGR00899 1123523002118 putative substrate translocation pore; other site 1123523002119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1123523002120 Serine incorporator (Serinc); Region: Serinc; pfam03348 1123523002121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523002122 Coenzyme A binding pocket [chemical binding]; other site 1123523002123 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1123523002124 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1123523002125 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1123523002126 hypothetical protein; Validated; Region: PRK00124 1123523002127 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1123523002128 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1123523002129 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1123523002130 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1123523002131 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1123523002132 Walker A/P-loop; other site 1123523002133 ATP binding site [chemical binding]; other site 1123523002134 Q-loop/lid; other site 1123523002135 ABC transporter signature motif; other site 1123523002136 Walker B; other site 1123523002137 D-loop; other site 1123523002138 H-loop/switch region; other site 1123523002139 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1123523002140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1123523002141 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1123523002142 Walker A/P-loop; other site 1123523002143 ATP binding site [chemical binding]; other site 1123523002144 Q-loop/lid; other site 1123523002145 ABC transporter signature motif; other site 1123523002146 Walker B; other site 1123523002147 D-loop; other site 1123523002148 H-loop/switch region; other site 1123523002149 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1123523002150 MarR family; Region: MarR; pfam01047 1123523002151 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1123523002152 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1123523002153 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1123523002154 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1123523002155 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1123523002156 active site 1123523002157 catalytic tetrad [active] 1123523002158 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1123523002159 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1123523002160 transmembrane helices; other site 1123523002161 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1123523002162 DNA photolyase; Region: DNA_photolyase; pfam00875 1123523002163 Predicted membrane protein [Function unknown]; Region: COG4330 1123523002164 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1123523002165 trimer interface [polypeptide binding]; other site 1123523002166 putative Zn binding site [ion binding]; other site 1123523002167 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1123523002168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523002169 putative substrate translocation pore; other site 1123523002170 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1123523002171 putative deacylase active site [active] 1123523002172 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1123523002173 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1123523002174 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1123523002175 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1123523002176 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1123523002177 putative substrate binding site [chemical binding]; other site 1123523002178 putative ATP binding site [chemical binding]; other site 1123523002179 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1123523002180 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1123523002181 active site 1123523002182 phosphorylation site [posttranslational modification] 1123523002183 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1123523002184 active site 1123523002185 P-loop; other site 1123523002186 phosphorylation site [posttranslational modification] 1123523002187 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1123523002188 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1123523002189 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1123523002190 active site 1123523002191 dimer interface [polypeptide binding]; other site 1123523002192 Domain of unknown function DUF21; Region: DUF21; pfam01595 1123523002193 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1123523002194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1123523002195 Transporter associated domain; Region: CorC_HlyC; pfam03471 1123523002196 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1123523002197 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1123523002198 active site 1123523002199 catalytic tetrad [active] 1123523002200 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1123523002201 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1123523002202 Ligand binding site; other site 1123523002203 Putative Catalytic site; other site 1123523002204 DXD motif; other site 1123523002205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1123523002206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1123523002207 dimer interface [polypeptide binding]; other site 1123523002208 phosphorylation site [posttranslational modification] 1123523002209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523002210 ATP binding site [chemical binding]; other site 1123523002211 Mg2+ binding site [ion binding]; other site 1123523002212 G-X-G motif; other site 1123523002213 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523002214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523002215 active site 1123523002216 phosphorylation site [posttranslational modification] 1123523002217 intermolecular recognition site; other site 1123523002218 dimerization interface [polypeptide binding]; other site 1123523002219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523002220 DNA binding site [nucleotide binding] 1123523002221 DoxX; Region: DoxX; pfam07681 1123523002222 Electron transfer DM13; Region: DM13; pfam10517 1123523002223 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1123523002224 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1123523002225 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 1123523002226 active site 1123523002227 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1123523002228 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1123523002229 Ligand Binding Site [chemical binding]; other site 1123523002230 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1123523002231 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1123523002232 glutamine binding [chemical binding]; other site 1123523002233 catalytic triad [active] 1123523002234 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1123523002235 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1123523002236 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1123523002237 substrate-cofactor binding pocket; other site 1123523002238 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1123523002239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523002240 catalytic residue [active] 1123523002241 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1123523002242 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1123523002243 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1123523002244 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1123523002245 Sulfatase; Region: Sulfatase; pfam00884 1123523002246 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1123523002247 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523002248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523002249 ABC transporter; Region: ABC_tran_2; pfam12848 1123523002250 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523002251 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1123523002252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523002253 ATP binding site [chemical binding]; other site 1123523002254 putative Mg++ binding site [ion binding]; other site 1123523002255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1123523002256 nucleotide binding region [chemical binding]; other site 1123523002257 ATP-binding site [chemical binding]; other site 1123523002258 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1123523002259 HRDC domain; Region: HRDC; pfam00570 1123523002260 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1123523002261 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1123523002262 Walker A/P-loop; other site 1123523002263 ATP binding site [chemical binding]; other site 1123523002264 Q-loop/lid; other site 1123523002265 ABC transporter signature motif; other site 1123523002266 Walker B; other site 1123523002267 D-loop; other site 1123523002268 H-loop/switch region; other site 1123523002269 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1123523002270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523002271 dimer interface [polypeptide binding]; other site 1123523002272 conserved gate region; other site 1123523002273 ABC-ATPase subunit interface; other site 1123523002274 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1123523002275 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1123523002276 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1123523002277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1123523002278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523002279 homodimer interface [polypeptide binding]; other site 1123523002280 catalytic residue [active] 1123523002281 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1123523002282 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1123523002283 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1123523002284 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1123523002285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523002286 putative substrate translocation pore; other site 1123523002287 POT family; Region: PTR2; cl17359 1123523002288 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1123523002289 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1123523002290 Protein involved in ribonucleotide reduction [Nucleotide transport and metabolism]; Region: NrdI; COG1780 1123523002291 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1123523002292 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1123523002293 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1123523002294 active site 1123523002295 dimer interface [polypeptide binding]; other site 1123523002296 catalytic residues [active] 1123523002297 effector binding site; other site 1123523002298 R2 peptide binding site; other site 1123523002299 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1123523002300 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1123523002301 dimer interface [polypeptide binding]; other site 1123523002302 putative radical transfer pathway; other site 1123523002303 diiron center [ion binding]; other site 1123523002304 tyrosyl radical; other site 1123523002305 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523002306 ABC-ATPase subunit interface; other site 1123523002307 dimer interface [polypeptide binding]; other site 1123523002308 putative PBP binding regions; other site 1123523002309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523002310 ABC-ATPase subunit interface; other site 1123523002311 dimer interface [polypeptide binding]; other site 1123523002312 putative PBP binding regions; other site 1123523002313 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1123523002314 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1123523002315 Walker A/P-loop; other site 1123523002316 ATP binding site [chemical binding]; other site 1123523002317 Q-loop/lid; other site 1123523002318 ABC transporter signature motif; other site 1123523002319 Walker B; other site 1123523002320 D-loop; other site 1123523002321 H-loop/switch region; other site 1123523002322 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1123523002323 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1123523002324 putative ligand binding residues [chemical binding]; other site 1123523002325 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906 1123523002326 FAD binding domain; Region: FAD_binding_4; pfam01565 1123523002327 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1123523002328 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1123523002329 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1123523002330 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1123523002331 peptidase T; Region: peptidase-T; TIGR01882 1123523002332 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1123523002333 metal binding site [ion binding]; metal-binding site 1123523002334 dimer interface [polypeptide binding]; other site 1123523002335 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1123523002336 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1123523002337 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1123523002338 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1123523002339 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1123523002340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1123523002341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1123523002342 metal binding site [ion binding]; metal-binding site 1123523002343 active site 1123523002344 I-site; other site 1123523002345 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1123523002346 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1123523002347 Mg++ binding site [ion binding]; other site 1123523002348 putative catalytic motif [active] 1123523002349 substrate binding site [chemical binding]; other site 1123523002350 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1123523002351 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1123523002352 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1123523002353 EDD domain protein, DegV family; Region: DegV; TIGR00762 1123523002354 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1123523002355 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1123523002356 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523002357 ATP binding site [chemical binding]; other site 1123523002358 putative Mg++ binding site [ion binding]; other site 1123523002359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1123523002360 nucleotide binding region [chemical binding]; other site 1123523002361 ATP-binding site [chemical binding]; other site 1123523002362 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1123523002363 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1123523002364 active site 1123523002365 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1123523002366 30S subunit binding site; other site 1123523002367 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1123523002368 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1123523002369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1123523002370 nucleotide binding region [chemical binding]; other site 1123523002371 ATP-binding site [chemical binding]; other site 1123523002372 SEC-C motif; Region: SEC-C; pfam02810 1123523002373 peptide chain release factor 2; Provisional; Region: PRK06746 1123523002374 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1123523002375 RF-1 domain; Region: RF-1; pfam00472 1123523002376 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1123523002377 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1123523002378 Surface antigen [General function prediction only]; Region: COG3942 1123523002379 CHAP domain; Region: CHAP; pfam05257 1123523002380 HD domain; Region: HD_3; cl17350 1123523002381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 1123523002382 excinuclease ABC subunit B; Provisional; Region: PRK05298 1123523002383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523002384 ATP binding site [chemical binding]; other site 1123523002385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1123523002386 nucleotide binding region [chemical binding]; other site 1123523002387 ATP-binding site [chemical binding]; other site 1123523002388 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1123523002389 UvrB/uvrC motif; Region: UVR; pfam02151 1123523002390 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1123523002391 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1123523002392 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1123523002393 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1123523002394 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1123523002395 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1123523002396 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1123523002397 Hpr binding site; other site 1123523002398 active site 1123523002399 homohexamer subunit interaction site [polypeptide binding]; other site 1123523002400 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1123523002401 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1123523002402 putative trimer interface [polypeptide binding]; other site 1123523002403 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1123523002404 putative CoA binding site [chemical binding]; other site 1123523002405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1123523002406 binding surface 1123523002407 TPR motif; other site 1123523002408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1123523002409 TPR motif; other site 1123523002410 binding surface 1123523002411 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1123523002412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1123523002413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523002414 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1123523002415 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1123523002416 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1123523002417 phosphate binding site [ion binding]; other site 1123523002418 dimer interface [polypeptide binding]; other site 1123523002419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1123523002420 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1123523002421 Clp protease; Region: CLP_protease; pfam00574 1123523002422 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1123523002423 oligomer interface [polypeptide binding]; other site 1123523002424 active site residues [active] 1123523002425 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1123523002426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1123523002427 NAD(P) binding site [chemical binding]; other site 1123523002428 active site 1123523002429 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1123523002430 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1123523002431 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1123523002432 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1123523002433 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1123523002434 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1123523002435 Phosphoglycerate kinase; Region: PGK; pfam00162 1123523002436 substrate binding site [chemical binding]; other site 1123523002437 hinge regions; other site 1123523002438 ADP binding site [chemical binding]; other site 1123523002439 catalytic site [active] 1123523002440 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1123523002441 triosephosphate isomerase; Provisional; Region: PRK14565 1123523002442 substrate binding site [chemical binding]; other site 1123523002443 dimer interface [polypeptide binding]; other site 1123523002444 catalytic triad [active] 1123523002445 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1123523002446 phosphoglyceromutase; Provisional; Region: PRK05434 1123523002447 enolase; Provisional; Region: eno; PRK00077 1123523002448 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1123523002449 dimer interface [polypeptide binding]; other site 1123523002450 metal binding site [ion binding]; metal-binding site 1123523002451 substrate binding pocket [chemical binding]; other site 1123523002452 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1123523002453 Esterase/lipase [General function prediction only]; Region: COG1647 1123523002454 Baculovirus DNA helicase; Region: Baculo_helicase; pfam04735 1123523002455 ribonuclease R; Region: RNase_R; TIGR02063 1123523002456 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1123523002457 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1123523002458 RNB domain; Region: RNB; pfam00773 1123523002459 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1123523002460 RNA binding site [nucleotide binding]; other site 1123523002461 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1123523002462 SmpB-tmRNA interface; other site 1123523002463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523002464 Coenzyme A binding pocket [chemical binding]; other site 1123523002465 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523002466 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1123523002467 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 1123523002468 Staphylococcal nuclease homologues; Region: SNc; smart00318 1123523002469 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1123523002470 Catalytic site; other site 1123523002471 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1123523002472 DNA-binding site [nucleotide binding]; DNA binding site 1123523002473 RNA-binding motif; other site 1123523002474 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1123523002475 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1123523002476 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1123523002477 catalytic core [active] 1123523002478 Lysine efflux permease [General function prediction only]; Region: COG1279 1123523002479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1123523002480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1123523002481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1123523002482 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1123523002483 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1123523002484 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1123523002485 active site 1123523002486 catalytic residue [active] 1123523002487 dimer interface [polypeptide binding]; other site 1123523002488 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1123523002489 putative FMN binding site [chemical binding]; other site 1123523002490 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1123523002491 catalytic residues [active] 1123523002492 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1123523002493 ArsC family; Region: ArsC; pfam03960 1123523002494 putative ArsC-like catalytic residues; other site 1123523002495 putative TRX-like catalytic residues [active] 1123523002496 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1123523002497 lipoyl attachment site [posttranslational modification]; other site 1123523002498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1123523002499 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1123523002500 putative active site [active] 1123523002501 putative metal binding site [ion binding]; other site 1123523002502 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1123523002503 catalytic residues [active] 1123523002504 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1123523002505 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1123523002506 Walker A/P-loop; other site 1123523002507 ATP binding site [chemical binding]; other site 1123523002508 Q-loop/lid; other site 1123523002509 ABC transporter signature motif; other site 1123523002510 Walker B; other site 1123523002511 D-loop; other site 1123523002512 H-loop/switch region; other site 1123523002513 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1123523002514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523002515 dimer interface [polypeptide binding]; other site 1123523002516 conserved gate region; other site 1123523002517 ABC-ATPase subunit interface; other site 1123523002518 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1123523002519 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1123523002520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1123523002521 Predicted membrane protein [Function unknown]; Region: COG2035 1123523002522 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1123523002523 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1123523002524 Walker A/P-loop; other site 1123523002525 ATP binding site [chemical binding]; other site 1123523002526 Q-loop/lid; other site 1123523002527 ABC transporter signature motif; other site 1123523002528 Walker B; other site 1123523002529 D-loop; other site 1123523002530 H-loop/switch region; other site 1123523002531 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1123523002532 FeS assembly protein SufD; Region: sufD; TIGR01981 1123523002533 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1123523002534 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1123523002535 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1123523002536 catalytic residue [active] 1123523002537 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1123523002538 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1123523002539 trimerization site [polypeptide binding]; other site 1123523002540 active site 1123523002541 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1123523002542 FeS assembly protein SufB; Region: sufB; TIGR01980 1123523002543 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1123523002544 Domain of unknown function DUF21; Region: DUF21; pfam01595 1123523002545 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1123523002546 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1123523002547 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1123523002548 FMN binding site [chemical binding]; other site 1123523002549 substrate binding site [chemical binding]; other site 1123523002550 putative catalytic residue [active] 1123523002551 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1123523002552 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1123523002553 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1123523002554 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1123523002555 active site 1123523002556 metal binding site [ion binding]; metal-binding site 1123523002557 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1123523002558 lipoyl synthase; Provisional; Region: PRK05481 1123523002559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523002560 FeS/SAM binding site; other site 1123523002561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1123523002562 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1123523002563 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1123523002564 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1123523002565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523002566 active site 1123523002567 motif I; other site 1123523002568 motif II; other site 1123523002569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523002570 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1123523002571 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1123523002572 dimerization interface [polypeptide binding]; other site 1123523002573 ligand binding site [chemical binding]; other site 1123523002574 NADP binding site [chemical binding]; other site 1123523002575 catalytic site [active] 1123523002576 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1123523002577 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1123523002578 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1123523002579 acyl-activating enzyme (AAE) consensus motif; other site 1123523002580 AMP binding site [chemical binding]; other site 1123523002581 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1123523002582 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1123523002583 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1123523002584 DltD N-terminal region; Region: DltD_N; pfam04915 1123523002585 DltD central region; Region: DltD_M; pfam04918 1123523002586 DltD C-terminal region; Region: DltD_C; pfam04914 1123523002587 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1123523002588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1123523002589 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1123523002590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523002591 hypothetical protein; Provisional; Region: PRK13669 1123523002592 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1123523002593 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1123523002594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523002595 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1123523002596 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1123523002597 interface (dimer of trimers) [polypeptide binding]; other site 1123523002598 Substrate-binding/catalytic site; other site 1123523002599 Zn-binding sites [ion binding]; other site 1123523002600 Predicted permease [General function prediction only]; Region: COG2056 1123523002601 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1123523002602 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1123523002603 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1123523002604 CoenzymeA binding site [chemical binding]; other site 1123523002605 subunit interaction site [polypeptide binding]; other site 1123523002606 PHB binding site; other site 1123523002607 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1123523002608 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1123523002609 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12587 1123523002610 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1123523002611 Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) subfamily; Region: 2a6301s05; TIGR00942 1123523002612 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1123523002613 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1123523002614 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1123523002615 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1123523002616 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1123523002617 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1123523002618 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1123523002619 Kinase associated protein B; Region: KapB; pfam08810 1123523002620 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1123523002621 active site 1123523002622 general stress protein 13; Validated; Region: PRK08059 1123523002623 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1123523002624 RNA binding site [nucleotide binding]; other site 1123523002625 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1123523002626 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1123523002627 putative active site [active] 1123523002628 putative FMN binding site [chemical binding]; other site 1123523002629 putative substrate binding site [chemical binding]; other site 1123523002630 putative catalytic residue [active] 1123523002631 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1123523002632 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1123523002633 inhibitor-cofactor binding pocket; inhibition site 1123523002634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523002635 catalytic residue [active] 1123523002636 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1123523002637 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1123523002638 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1123523002639 NAD(P) binding site [chemical binding]; other site 1123523002640 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1123523002641 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1123523002642 active site 1123523002643 catalytic site [active] 1123523002644 metal binding site [ion binding]; metal-binding site 1123523002645 argininosuccinate lyase; Provisional; Region: PRK00855 1123523002646 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1123523002647 active sites [active] 1123523002648 tetramer interface [polypeptide binding]; other site 1123523002649 argininosuccinate synthase; Provisional; Region: PRK13820 1123523002650 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1123523002651 ANP binding site [chemical binding]; other site 1123523002652 Substrate Binding Site II [chemical binding]; other site 1123523002653 Substrate Binding Site I [chemical binding]; other site 1123523002654 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1123523002655 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1123523002656 active site 1123523002657 dimer interface [polypeptide binding]; other site 1123523002658 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1123523002659 dimer interface [polypeptide binding]; other site 1123523002660 active site 1123523002661 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1123523002662 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1123523002663 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1123523002664 Catalytic site [active] 1123523002665 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1123523002666 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1123523002667 Catalytic site [active] 1123523002668 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1123523002669 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1123523002670 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1123523002671 Part of AAA domain; Region: AAA_19; pfam13245 1123523002672 Family description; Region: UvrD_C_2; pfam13538 1123523002673 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1123523002674 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1123523002675 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1123523002676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1123523002677 hypothetical protein; Provisional; Region: PRK13673 1123523002678 coenzyme A disulfide reductase; Provisional; Region: PRK13512 1123523002679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1123523002680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523002681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1123523002682 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1123523002683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523002684 active site 1123523002685 motif I; other site 1123523002686 motif II; other site 1123523002687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523002688 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1123523002689 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1123523002690 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1123523002691 catalytic triad [active] 1123523002692 catalytic triad [active] 1123523002693 oxyanion hole [active] 1123523002694 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1123523002695 Clp amino terminal domain; Region: Clp_N; pfam02861 1123523002696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523002697 Walker A motif; other site 1123523002698 ATP binding site [chemical binding]; other site 1123523002699 Walker B motif; other site 1123523002700 arginine finger; other site 1123523002701 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1123523002702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523002703 Walker A motif; other site 1123523002704 ATP binding site [chemical binding]; other site 1123523002705 Walker B motif; other site 1123523002706 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1123523002707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1123523002708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1123523002709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1123523002710 dimerization interface [polypeptide binding]; other site 1123523002711 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1123523002712 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1123523002713 active site 1123523002714 catalytic residues [active] 1123523002715 metal binding site [ion binding]; metal-binding site 1123523002716 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1123523002717 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1123523002718 substrate binding site [chemical binding]; other site 1123523002719 MAP domain; Region: MAP; pfam03642 1123523002720 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1123523002721 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1123523002722 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1123523002723 dimer interface [polypeptide binding]; other site 1123523002724 active site 1123523002725 CoA binding pocket [chemical binding]; other site 1123523002726 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1123523002727 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1123523002728 dimer interface [polypeptide binding]; other site 1123523002729 active site 1123523002730 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1123523002731 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1123523002732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523002733 dimer interface [polypeptide binding]; other site 1123523002734 conserved gate region; other site 1123523002735 putative PBP binding loops; other site 1123523002736 ABC-ATPase subunit interface; other site 1123523002737 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1123523002738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523002739 dimer interface [polypeptide binding]; other site 1123523002740 conserved gate region; other site 1123523002741 putative PBP binding loops; other site 1123523002742 ABC-ATPase subunit interface; other site 1123523002743 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1123523002744 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523002745 Walker A/P-loop; other site 1123523002746 ATP binding site [chemical binding]; other site 1123523002747 Q-loop/lid; other site 1123523002748 ABC transporter signature motif; other site 1123523002749 Walker B; other site 1123523002750 D-loop; other site 1123523002751 H-loop/switch region; other site 1123523002752 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1123523002753 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1123523002754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523002755 Walker A/P-loop; other site 1123523002756 ATP binding site [chemical binding]; other site 1123523002757 Q-loop/lid; other site 1123523002758 ABC transporter signature motif; other site 1123523002759 Walker B; other site 1123523002760 D-loop; other site 1123523002761 H-loop/switch region; other site 1123523002762 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1123523002763 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1123523002764 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1123523002765 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1123523002766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523002767 Walker A/P-loop; other site 1123523002768 ATP binding site [chemical binding]; other site 1123523002769 Q-loop/lid; other site 1123523002770 ABC transporter signature motif; other site 1123523002771 Walker B; other site 1123523002772 D-loop; other site 1123523002773 H-loop/switch region; other site 1123523002774 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1123523002775 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1123523002776 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523002777 Walker A/P-loop; other site 1123523002778 ATP binding site [chemical binding]; other site 1123523002779 Q-loop/lid; other site 1123523002780 ABC transporter signature motif; other site 1123523002781 Walker B; other site 1123523002782 D-loop; other site 1123523002783 H-loop/switch region; other site 1123523002784 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1123523002785 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1123523002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523002787 dimer interface [polypeptide binding]; other site 1123523002788 conserved gate region; other site 1123523002789 putative PBP binding loops; other site 1123523002790 ABC-ATPase subunit interface; other site 1123523002791 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1123523002792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523002793 dimer interface [polypeptide binding]; other site 1123523002794 conserved gate region; other site 1123523002795 putative PBP binding loops; other site 1123523002796 ABC-ATPase subunit interface; other site 1123523002797 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1123523002798 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1123523002799 active site 1123523002800 HIGH motif; other site 1123523002801 dimer interface [polypeptide binding]; other site 1123523002802 KMSKS motif; other site 1123523002803 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1123523002804 ArsC family; Region: ArsC; pfam03960 1123523002805 putative catalytic residues [active] 1123523002806 thiol/disulfide switch; other site 1123523002807 adaptor protein; Provisional; Region: PRK02315 1123523002808 Competence protein CoiA-like family; Region: CoiA; cl11541 1123523002809 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1123523002810 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1123523002811 active site 1123523002812 Zn binding site [ion binding]; other site 1123523002813 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1123523002814 Thioredoxin; Region: Thioredoxin_5; pfam13743 1123523002815 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1123523002816 apolar tunnel; other site 1123523002817 heme binding site [chemical binding]; other site 1123523002818 dimerization interface [polypeptide binding]; other site 1123523002819 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1123523002820 putative active site [active] 1123523002821 putative metal binding residues [ion binding]; other site 1123523002822 signature motif; other site 1123523002823 putative triphosphate binding site [ion binding]; other site 1123523002824 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1123523002825 synthetase active site [active] 1123523002826 NTP binding site [chemical binding]; other site 1123523002827 metal binding site [ion binding]; metal-binding site 1123523002828 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1123523002829 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1123523002830 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1123523002831 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1123523002832 active site 1123523002833 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1123523002834 MgtE intracellular N domain; Region: MgtE_N; smart00924 1123523002835 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1123523002836 Divalent cation transporter; Region: MgtE; pfam01769 1123523002837 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1123523002838 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1123523002839 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1123523002840 TrkA-N domain; Region: TrkA_N; pfam02254 1123523002841 TrkA-C domain; Region: TrkA_C; pfam02080 1123523002842 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1123523002843 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1123523002844 NAD binding site [chemical binding]; other site 1123523002845 homotetramer interface [polypeptide binding]; other site 1123523002846 homodimer interface [polypeptide binding]; other site 1123523002847 substrate binding site [chemical binding]; other site 1123523002848 active site 1123523002849 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1123523002850 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1123523002851 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1123523002852 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1123523002853 Putative esterase; Region: Esterase; pfam00756 1123523002854 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1123523002855 hypothetical protein; Provisional; Region: PRK13679 1123523002856 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1123523002857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523002858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523002859 putative substrate translocation pore; other site 1123523002860 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1123523002861 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1123523002862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1123523002863 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1123523002864 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1123523002865 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1123523002866 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1123523002867 YueH-like protein; Region: YueH; pfam14166 1123523002868 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1123523002869 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1123523002870 G1 box; other site 1123523002871 putative GEF interaction site [polypeptide binding]; other site 1123523002872 GTP/Mg2+ binding site [chemical binding]; other site 1123523002873 Switch I region; other site 1123523002874 G2 box; other site 1123523002875 G3 box; other site 1123523002876 Switch II region; other site 1123523002877 G4 box; other site 1123523002878 G5 box; other site 1123523002879 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1123523002880 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1123523002881 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1123523002882 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1123523002883 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1123523002884 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1123523002885 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1123523002886 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1123523002887 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1123523002888 active site 1123523002889 metal binding site [ion binding]; metal-binding site 1123523002890 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1123523002891 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1123523002892 IDEAL domain; Region: IDEAL; pfam08858 1123523002893 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1123523002894 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1123523002895 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1123523002896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1123523002897 CAAX protease self-immunity; Region: Abi; pfam02517 1123523002898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1123523002899 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1123523002900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1123523002901 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1123523002902 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1123523002903 Walker A/P-loop; other site 1123523002904 ATP binding site [chemical binding]; other site 1123523002905 Q-loop/lid; other site 1123523002906 ABC transporter signature motif; other site 1123523002907 Walker B; other site 1123523002908 D-loop; other site 1123523002909 H-loop/switch region; other site 1123523002910 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1123523002911 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1123523002912 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1123523002913 Predicted membrane protein [Function unknown]; Region: COG2259 1123523002914 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1123523002915 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1123523002916 siderophore binding site; other site 1123523002917 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1123523002918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523002919 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1123523002920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1123523002921 Coenzyme A binding pocket [chemical binding]; other site 1123523002922 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1123523002923 UbiA prenyltransferase family; Region: UbiA; pfam01040 1123523002924 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1123523002925 isochorismate synthases; Region: isochor_syn; TIGR00543 1123523002926 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1123523002927 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1123523002928 dimer interface [polypeptide binding]; other site 1123523002929 tetramer interface [polypeptide binding]; other site 1123523002930 PYR/PP interface [polypeptide binding]; other site 1123523002931 TPP binding site [chemical binding]; other site 1123523002932 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1123523002933 TPP-binding site; other site 1123523002934 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1123523002935 PGAP1-like protein; Region: PGAP1; pfam07819 1123523002936 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1123523002937 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1123523002938 substrate binding site [chemical binding]; other site 1123523002939 oxyanion hole (OAH) forming residues; other site 1123523002940 trimer interface [polypeptide binding]; other site 1123523002941 Staphostatin B; Region: Staphostatin_B; pfam09023 1123523002942 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1123523002943 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1123523002944 aminotransferase A; Validated; Region: PRK07683 1123523002945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1123523002946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523002947 homodimer interface [polypeptide binding]; other site 1123523002948 catalytic residue [active] 1123523002949 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1123523002950 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1123523002951 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1123523002952 MarR family; Region: MarR; pfam01047 1123523002953 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1123523002954 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1123523002955 amidase catalytic site [active] 1123523002956 Zn binding residues [ion binding]; other site 1123523002957 substrate binding site [chemical binding]; other site 1123523002958 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1123523002959 Lysozyme subfamily 2; Region: LYZ2; smart00047 1123523002960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523002961 Coenzyme A binding pocket [chemical binding]; other site 1123523002962 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1123523002963 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1123523002964 Beta-lactamase; Region: Beta-lactamase; pfam00144 1123523002965 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1123523002966 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 1123523002967 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1123523002968 Subunit I/III interface [polypeptide binding]; other site 1123523002969 Subunit III/IV interface [polypeptide binding]; other site 1123523002970 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1123523002971 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1123523002972 D-pathway; other site 1123523002973 Putative ubiquinol binding site [chemical binding]; other site 1123523002974 Low-spin heme (heme b) binding site [chemical binding]; other site 1123523002975 Putative water exit pathway; other site 1123523002976 Binuclear center (heme o3/CuB) [ion binding]; other site 1123523002977 K-pathway; other site 1123523002978 Putative proton exit pathway; other site 1123523002979 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1123523002980 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1123523002981 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1123523002982 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1123523002983 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14175 1123523002984 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1123523002985 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1123523002986 homodimer interface [polypeptide binding]; other site 1123523002987 NADP binding site [chemical binding]; other site 1123523002988 substrate binding site [chemical binding]; other site 1123523002989 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1123523002990 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1123523002991 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1123523002992 NAD binding site [chemical binding]; other site 1123523002993 ATP-grasp domain; Region: ATP-grasp; pfam02222 1123523002994 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1123523002995 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1123523002996 ATP binding site [chemical binding]; other site 1123523002997 active site 1123523002998 substrate binding site [chemical binding]; other site 1123523002999 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828 1123523003000 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1123523003001 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1123523003002 putative active site [active] 1123523003003 catalytic triad [active] 1123523003004 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1123523003005 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1123523003006 dimerization interface [polypeptide binding]; other site 1123523003007 ATP binding site [chemical binding]; other site 1123523003008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1123523003009 dimerization interface [polypeptide binding]; other site 1123523003010 ATP binding site [chemical binding]; other site 1123523003011 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1123523003012 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1123523003013 active site 1123523003014 tetramer interface [polypeptide binding]; other site 1123523003015 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1123523003016 active site 1123523003017 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1123523003018 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1123523003019 dimerization interface [polypeptide binding]; other site 1123523003020 putative ATP binding site [chemical binding]; other site 1123523003021 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1123523003022 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1123523003023 active site 1123523003024 substrate binding site [chemical binding]; other site 1123523003025 cosubstrate binding site; other site 1123523003026 catalytic site [active] 1123523003027 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1123523003028 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1123523003029 purine monophosphate binding site [chemical binding]; other site 1123523003030 dimer interface [polypeptide binding]; other site 1123523003031 putative catalytic residues [active] 1123523003032 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1123523003033 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1123523003034 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1123523003035 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 1123523003036 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1123523003037 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1123523003038 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1123523003039 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1123523003040 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1123523003041 Walker A/P-loop; other site 1123523003042 ATP binding site [chemical binding]; other site 1123523003043 Q-loop/lid; other site 1123523003044 ABC transporter signature motif; other site 1123523003045 Walker B; other site 1123523003046 D-loop; other site 1123523003047 H-loop/switch region; other site 1123523003048 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1123523003049 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1123523003050 Walker A/P-loop; other site 1123523003051 ATP binding site [chemical binding]; other site 1123523003052 Q-loop/lid; other site 1123523003053 ABC transporter signature motif; other site 1123523003054 Walker B; other site 1123523003055 D-loop; other site 1123523003056 H-loop/switch region; other site 1123523003057 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1123523003058 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1123523003059 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1123523003060 putative RNA binding site [nucleotide binding]; other site 1123523003061 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1123523003062 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1123523003063 dimerization domain swap beta strand [polypeptide binding]; other site 1123523003064 regulatory protein interface [polypeptide binding]; other site 1123523003065 active site 1123523003066 regulatory phosphorylation site [posttranslational modification]; other site 1123523003067 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1123523003068 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1123523003069 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1123523003070 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1123523003071 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1123523003072 catalytic residues [active] 1123523003073 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1123523003074 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1123523003075 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1123523003076 TrkA-N domain; Region: TrkA_N; pfam02254 1123523003077 TrkA-C domain; Region: TrkA_C; pfam02080 1123523003078 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1123523003079 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1123523003080 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1123523003081 hypothetical protein; Provisional; Region: PRK13667 1123523003082 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1123523003083 active site 1123523003084 catalytic residues [active] 1123523003085 metal binding site [ion binding]; metal-binding site 1123523003086 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1123523003087 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1123523003088 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1123523003089 TPP-binding site [chemical binding]; other site 1123523003090 tetramer interface [polypeptide binding]; other site 1123523003091 heterodimer interface [polypeptide binding]; other site 1123523003092 phosphorylation loop region [posttranslational modification] 1123523003093 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1123523003094 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1123523003095 alpha subunit interface [polypeptide binding]; other site 1123523003096 TPP binding site [chemical binding]; other site 1123523003097 heterodimer interface [polypeptide binding]; other site 1123523003098 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1123523003099 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1123523003100 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1123523003101 E3 interaction surface; other site 1123523003102 lipoyl attachment site [posttranslational modification]; other site 1123523003103 e3 binding domain; Region: E3_binding; pfam02817 1123523003104 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1123523003105 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1123523003106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1123523003107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523003108 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1123523003109 hypothetical protein; Provisional; Region: PRK04387 1123523003110 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1123523003111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523003112 non-specific DNA binding site [nucleotide binding]; other site 1123523003113 salt bridge; other site 1123523003114 sequence-specific DNA binding site [nucleotide binding]; other site 1123523003115 Cupin domain; Region: Cupin_2; pfam07883 1123523003116 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1123523003117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523003118 Walker A/P-loop; other site 1123523003119 ATP binding site [chemical binding]; other site 1123523003120 Q-loop/lid; other site 1123523003121 ABC transporter signature motif; other site 1123523003122 Walker B; other site 1123523003123 D-loop; other site 1123523003124 H-loop/switch region; other site 1123523003125 TOBE domain; Region: TOBE_2; pfam08402 1123523003126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523003127 putative PBP binding loops; other site 1123523003128 dimer interface [polypeptide binding]; other site 1123523003129 ABC-ATPase subunit interface; other site 1123523003130 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1123523003131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523003132 dimer interface [polypeptide binding]; other site 1123523003133 conserved gate region; other site 1123523003134 putative PBP binding loops; other site 1123523003135 ABC-ATPase subunit interface; other site 1123523003136 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1123523003137 Toxin Fst, type I toxin-antitoxin system; Region: Fst_toxin; pfam13955 1123523003138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1123523003139 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1123523003140 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1123523003141 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1123523003142 manganese transport protein MntH; Reviewed; Region: PRK00701 1123523003143 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1123523003144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1123523003145 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1123523003146 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1123523003147 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1123523003148 active site 1123523003149 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1123523003150 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1123523003151 G1 box; other site 1123523003152 putative GEF interaction site [polypeptide binding]; other site 1123523003153 GTP/Mg2+ binding site [chemical binding]; other site 1123523003154 Switch I region; other site 1123523003155 G2 box; other site 1123523003156 G3 box; other site 1123523003157 Switch II region; other site 1123523003158 G4 box; other site 1123523003159 G5 box; other site 1123523003160 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1123523003161 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1123523003162 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1123523003163 hypothetical protein; Provisional; Region: PRK13666 1123523003164 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1123523003165 pyruvate carboxylase; Reviewed; Region: PRK12999 1123523003166 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1123523003167 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1123523003168 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1123523003169 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1123523003170 active site 1123523003171 catalytic residues [active] 1123523003172 metal binding site [ion binding]; metal-binding site 1123523003173 homodimer binding site [polypeptide binding]; other site 1123523003174 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1123523003175 carboxyltransferase (CT) interaction site; other site 1123523003176 biotinylation site [posttranslational modification]; other site 1123523003177 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1123523003178 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1123523003179 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1123523003180 UbiA prenyltransferase family; Region: UbiA; pfam01040 1123523003181 Predicted membrane protein [Function unknown]; Region: COG2322 1123523003182 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1123523003183 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1123523003184 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1123523003185 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1123523003186 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1123523003187 putative active site [active] 1123523003188 catalytic site [active] 1123523003189 putative metal binding site [ion binding]; other site 1123523003190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4471 1123523003191 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1123523003192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523003193 S-adenosylmethionine binding site [chemical binding]; other site 1123523003194 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1123523003195 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1123523003196 active site 1123523003197 (T/H)XGH motif; other site 1123523003198 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1123523003199 hypothetical protein; Provisional; Region: PRK13670 1123523003200 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1123523003201 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1123523003202 heme uptake protein IsdB; Region: IsdB; TIGR03657 1123523003203 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523003204 NEAr Transporter domain; Region: NEAT; smart00725 1123523003205 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1123523003206 heme-binding site [chemical binding]; other site 1123523003207 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1123523003208 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1123523003209 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1123523003210 heme-binding site [chemical binding]; other site 1123523003211 heme uptake protein IsdC; Region: IsdC; TIGR03656 1123523003212 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1123523003213 heme-binding site [chemical binding]; other site 1123523003214 sortase B signal domain, NPQTN class; Region: srtB_sig_NPQTN; TIGR03068 1123523003215 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1123523003216 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1123523003217 intersubunit interface [polypeptide binding]; other site 1123523003218 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1123523003219 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523003220 ABC-ATPase subunit interface; other site 1123523003221 dimer interface [polypeptide binding]; other site 1123523003222 putative PBP binding regions; other site 1123523003223 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1123523003224 active site 1123523003225 catalytic site [active] 1123523003226 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13312 1123523003227 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1123523003228 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1123523003229 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1123523003230 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1123523003231 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1123523003232 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1123523003233 dimer interface [polypeptide binding]; other site 1123523003234 motif 1; other site 1123523003235 active site 1123523003236 motif 2; other site 1123523003237 motif 3; other site 1123523003238 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1123523003239 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1123523003240 putative tRNA-binding site [nucleotide binding]; other site 1123523003241 B3/4 domain; Region: B3_4; pfam03483 1123523003242 tRNA synthetase B5 domain; Region: B5; smart00874 1123523003243 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1123523003244 dimer interface [polypeptide binding]; other site 1123523003245 motif 1; other site 1123523003246 motif 3; other site 1123523003247 motif 2; other site 1123523003248 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1123523003249 ribonuclease HIII; Provisional; Region: PRK00996 1123523003250 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1123523003251 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1123523003252 RNA/DNA hybrid binding site [nucleotide binding]; other site 1123523003253 active site 1123523003254 Cell division protein ZapA; Region: ZapA; cl01146 1123523003255 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1123523003256 Colicin V production protein; Region: Colicin_V; pfam02674 1123523003257 hypothetical protein; Provisional; Region: PRK08609 1123523003258 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1123523003259 active site 1123523003260 primer binding site [nucleotide binding]; other site 1123523003261 NTP binding site [chemical binding]; other site 1123523003262 metal binding triad [ion binding]; metal-binding site 1123523003263 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1123523003264 active site 1123523003265 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1123523003266 MutS domain III; Region: MutS_III; pfam05192 1123523003267 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1123523003268 Walker A/P-loop; other site 1123523003269 ATP binding site [chemical binding]; other site 1123523003270 Q-loop/lid; other site 1123523003271 ABC transporter signature motif; other site 1123523003272 Walker B; other site 1123523003273 D-loop; other site 1123523003274 H-loop/switch region; other site 1123523003275 Smr domain; Region: Smr; pfam01713 1123523003276 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1123523003277 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1123523003278 catalytic residues [active] 1123523003279 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1123523003280 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1123523003281 GIY-YIG motif/motif A; other site 1123523003282 active site 1123523003283 catalytic site [active] 1123523003284 putative DNA binding site [nucleotide binding]; other site 1123523003285 metal binding site [ion binding]; metal-binding site 1123523003286 UvrB/uvrC motif; Region: UVR; pfam02151 1123523003287 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1123523003288 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1123523003289 putative Iron-sulfur protein interface [polypeptide binding]; other site 1123523003290 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1123523003291 proximal heme binding site [chemical binding]; other site 1123523003292 distal heme binding site [chemical binding]; other site 1123523003293 putative dimer interface [polypeptide binding]; other site 1123523003294 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1123523003295 L-aspartate oxidase; Provisional; Region: PRK06175 1123523003296 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1123523003297 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1123523003298 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1123523003299 glutamate racemase; Provisional; Region: PRK00865 1123523003300 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1123523003301 active site 1123523003302 dimerization interface [polypeptide binding]; other site 1123523003303 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1123523003304 active site 1123523003305 metal binding site [ion binding]; metal-binding site 1123523003306 homotetramer interface [polypeptide binding]; other site 1123523003307 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1123523003308 formyl peptide receptor-like 1 inhibitory protein; Reviewed; Region: PRK13033 1123523003309 Extracellular fibrinogen binding protein C terminal; Region: efb-c; pfam12199 1123523003310 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1123523003311 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1123523003312 superantigen-like protein; Reviewed; Region: PRK13350 1123523003313 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523003314 superantigen-like protein; Reviewed; Region: PRK13349 1123523003315 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523003316 superantigen-like protein; Reviewed; Region: PRK13043 1123523003317 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523003318 ornithine carbamoyltransferase; Provisional; Region: PRK04284 1123523003319 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1123523003320 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1123523003321 carbamate kinase; Reviewed; Region: PRK12686 1123523003322 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1123523003323 putative substrate binding site [chemical binding]; other site 1123523003324 nucleotide binding site [chemical binding]; other site 1123523003325 nucleotide binding site [chemical binding]; other site 1123523003326 homodimer interface [polypeptide binding]; other site 1123523003327 Predicted membrane protein [Function unknown]; Region: COG1288 1123523003328 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1123523003329 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1123523003330 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1123523003331 gating phenylalanine in ion channel; other site 1123523003332 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1123523003333 Staphylococcus haemolytic protein; Region: Staph_haemo; pfam05480 1123523003334 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1123523003335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523003336 motif II; other site 1123523003337 hypothetical protein; Provisional; Region: PRK13688 1123523003338 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1123523003339 Coenzyme A binding pocket [chemical binding]; other site 1123523003340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1123523003341 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1123523003342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1123523003343 MraZ protein; Region: MraZ; pfam02381 1123523003344 MraZ protein; Region: MraZ; pfam02381 1123523003345 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1123523003346 MraW methylase family; Region: Methyltransf_5; pfam01795 1123523003347 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1123523003348 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1123523003349 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1123523003350 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1123523003351 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1123523003352 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1123523003353 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1123523003354 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1123523003355 Mg++ binding site [ion binding]; other site 1123523003356 putative catalytic motif [active] 1123523003357 putative substrate binding site [chemical binding]; other site 1123523003358 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1123523003359 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1123523003360 NAD binding site [chemical binding]; other site 1123523003361 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1123523003362 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1123523003363 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1123523003364 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1123523003365 Cell division protein FtsQ; Region: FtsQ; pfam03799 1123523003366 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1123523003367 Cell division protein FtsA; Region: FtsA; smart00842 1123523003368 Cell division protein FtsA; Region: FtsA; pfam14450 1123523003369 cell division protein FtsZ; Validated; Region: PRK09330 1123523003370 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1123523003371 nucleotide binding site [chemical binding]; other site 1123523003372 SulA interaction site; other site 1123523003373 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1123523003374 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1123523003375 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1123523003376 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1123523003377 catalytic residue [active] 1123523003378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1123523003379 YGGT family; Region: YGGT; pfam02325 1123523003380 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1123523003381 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1123523003382 RNA binding surface [nucleotide binding]; other site 1123523003383 DivIVA protein; Region: DivIVA; pfam05103 1123523003384 DivIVA domain; Region: DivI1A_domain; TIGR03544 1123523003385 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1123523003386 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1123523003387 HIGH motif; other site 1123523003388 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1123523003389 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1123523003390 active site 1123523003391 KMSKS motif; other site 1123523003392 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1123523003393 tRNA binding surface [nucleotide binding]; other site 1123523003394 anticodon binding site; other site 1123523003395 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1123523003396 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1123523003397 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1123523003398 active site 1123523003399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1123523003400 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1123523003401 lipoprotein signal peptidase; Provisional; Region: PRK14787 1123523003402 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1123523003403 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1123523003404 RNA binding surface [nucleotide binding]; other site 1123523003405 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1123523003406 active site 1123523003407 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1123523003408 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1123523003409 uracil transporter; Provisional; Region: PRK10720 1123523003410 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1123523003411 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1123523003412 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1123523003413 dihydroorotase; Validated; Region: pyrC; PRK09357 1123523003414 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1123523003415 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1123523003416 active site 1123523003417 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1123523003418 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1123523003419 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1123523003420 catalytic site [active] 1123523003421 subunit interface [polypeptide binding]; other site 1123523003422 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1123523003423 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1123523003424 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1123523003425 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1123523003426 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1123523003427 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1123523003428 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1123523003429 IMP binding site; other site 1123523003430 dimer interface [polypeptide binding]; other site 1123523003431 interdomain contacts; other site 1123523003432 partial ornithine binding site; other site 1123523003433 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1123523003434 active site 1123523003435 dimer interface [polypeptide binding]; other site 1123523003436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1123523003437 active site 1123523003438 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1123523003439 dimer interface [polypeptide binding]; other site 1123523003440 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1123523003441 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1123523003442 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1123523003443 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1123523003444 catalytic site [active] 1123523003445 G-X2-G-X-G-K; other site 1123523003446 DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758 1123523003447 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1123523003448 Flavoprotein; Region: Flavoprotein; pfam02441 1123523003449 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1123523003450 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1123523003451 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523003452 ATP binding site [chemical binding]; other site 1123523003453 putative Mg++ binding site [ion binding]; other site 1123523003454 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1123523003455 nucleotide binding region [chemical binding]; other site 1123523003456 ATP-binding site [chemical binding]; other site 1123523003457 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1123523003458 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1123523003459 active site 1123523003460 catalytic residues [active] 1123523003461 metal binding site [ion binding]; metal-binding site 1123523003462 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1123523003463 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1123523003464 putative active site [active] 1123523003465 substrate binding site [chemical binding]; other site 1123523003466 putative cosubstrate binding site; other site 1123523003467 catalytic site [active] 1123523003468 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1123523003469 substrate binding site [chemical binding]; other site 1123523003470 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1123523003471 NusB family; Region: NusB; pfam01029 1123523003472 putative RNA binding site [nucleotide binding]; other site 1123523003473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523003474 S-adenosylmethionine binding site [chemical binding]; other site 1123523003475 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1123523003476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523003477 FeS/SAM binding site; other site 1123523003478 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1123523003479 Protein phosphatase 2C; Region: PP2C; pfam00481 1123523003480 active site 1123523003481 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1123523003482 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1123523003483 active site 1123523003484 ATP binding site [chemical binding]; other site 1123523003485 substrate binding site [chemical binding]; other site 1123523003486 activation loop (A-loop); other site 1123523003487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1123523003488 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1123523003489 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1123523003490 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1123523003491 Predicted GTPases [General function prediction only]; Region: COG1162 1123523003492 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1123523003493 RNA binding site [nucleotide binding]; other site 1123523003494 homodimer interface [polypeptide binding]; other site 1123523003495 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1123523003496 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1123523003497 GTP/Mg2+ binding site [chemical binding]; other site 1123523003498 G4 box; other site 1123523003499 G5 box; other site 1123523003500 G1 box; other site 1123523003501 Switch I region; other site 1123523003502 G2 box; other site 1123523003503 G3 box; other site 1123523003504 Switch II region; other site 1123523003505 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1123523003506 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1123523003507 substrate binding site [chemical binding]; other site 1123523003508 hexamer interface [polypeptide binding]; other site 1123523003509 metal binding site [ion binding]; metal-binding site 1123523003510 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1123523003511 Thiamine pyrophosphokinase; Region: TPK; cd07995 1123523003512 active site 1123523003513 dimerization interface [polypeptide binding]; other site 1123523003514 thiamine binding site [chemical binding]; other site 1123523003515 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1123523003516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1123523003517 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1123523003518 DAK2 domain; Region: Dak2; pfam02734 1123523003519 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1123523003520 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1123523003521 generic binding surface II; other site 1123523003522 ssDNA binding site; other site 1123523003523 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523003524 ATP binding site [chemical binding]; other site 1123523003525 putative Mg++ binding site [ion binding]; other site 1123523003526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1123523003527 nucleotide binding region [chemical binding]; other site 1123523003528 ATP-binding site [chemical binding]; other site 1123523003529 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1123523003530 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1123523003531 active site 2 [active] 1123523003532 active site 1 [active] 1123523003533 putative phosphate acyltransferase; Provisional; Region: PRK05331 1123523003534 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1123523003535 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1123523003536 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1123523003537 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1123523003538 NAD(P) binding site [chemical binding]; other site 1123523003539 homotetramer interface [polypeptide binding]; other site 1123523003540 homodimer interface [polypeptide binding]; other site 1123523003541 active site 1123523003542 acyl carrier protein; Provisional; Region: acpP; PRK00982 1123523003543 ribonuclease III; Reviewed; Region: rnc; PRK00102 1123523003544 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1123523003545 dimerization interface [polypeptide binding]; other site 1123523003546 active site 1123523003547 metal binding site [ion binding]; metal-binding site 1123523003548 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1123523003549 dsRNA binding site [nucleotide binding]; other site 1123523003550 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1123523003551 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1123523003552 Walker A/P-loop; other site 1123523003553 ATP binding site [chemical binding]; other site 1123523003554 Q-loop/lid; other site 1123523003555 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1123523003556 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1123523003557 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1123523003558 ABC transporter signature motif; other site 1123523003559 Walker B; other site 1123523003560 D-loop; other site 1123523003561 H-loop/switch region; other site 1123523003562 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1123523003563 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1123523003564 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1123523003565 P loop; other site 1123523003566 GTP binding site [chemical binding]; other site 1123523003567 putative DNA-binding protein; Validated; Region: PRK00118 1123523003568 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1123523003569 signal recognition particle protein; Provisional; Region: PRK10867 1123523003570 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1123523003571 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1123523003572 P loop; other site 1123523003573 GTP binding site [chemical binding]; other site 1123523003574 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1123523003575 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1123523003576 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1123523003577 RimM N-terminal domain; Region: RimM; pfam01782 1123523003578 PRC-barrel domain; Region: PRC; pfam05239 1123523003579 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1123523003580 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1123523003581 Predicted membrane protein [Function unknown]; Region: COG4485 1123523003582 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1123523003583 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1123523003584 GTP/Mg2+ binding site [chemical binding]; other site 1123523003585 G4 box; other site 1123523003586 G5 box; other site 1123523003587 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1123523003588 G1 box; other site 1123523003589 G1 box; other site 1123523003590 GTP/Mg2+ binding site [chemical binding]; other site 1123523003591 Switch I region; other site 1123523003592 G2 box; other site 1123523003593 G2 box; other site 1123523003594 G3 box; other site 1123523003595 G3 box; other site 1123523003596 Switch II region; other site 1123523003597 Switch II region; other site 1123523003598 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1123523003599 RNA/DNA hybrid binding site [nucleotide binding]; other site 1123523003600 active site 1123523003601 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1123523003602 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1123523003603 CoA-ligase; Region: Ligase_CoA; pfam00549 1123523003604 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1123523003605 CoA binding domain; Region: CoA_binding; pfam02629 1123523003606 CoA-ligase; Region: Ligase_CoA; pfam00549 1123523003607 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1123523003608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1123523003609 CHAP domain; Region: CHAP; pfam05257 1123523003610 FemAB family; Region: FemAB; pfam02388 1123523003611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1123523003612 DNA protecting protein DprA; Region: dprA; TIGR00732 1123523003613 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1123523003614 DNA topoisomerase I; Validated; Region: PRK05582 1123523003615 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1123523003616 active site 1123523003617 interdomain interaction site; other site 1123523003618 putative metal-binding site [ion binding]; other site 1123523003619 nucleotide binding site [chemical binding]; other site 1123523003620 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1123523003621 domain I; other site 1123523003622 DNA binding groove [nucleotide binding] 1123523003623 phosphate binding site [ion binding]; other site 1123523003624 domain II; other site 1123523003625 domain III; other site 1123523003626 nucleotide binding site [chemical binding]; other site 1123523003627 catalytic site [active] 1123523003628 domain IV; other site 1123523003629 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1123523003630 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1123523003631 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1123523003632 Glucose inhibited division protein A; Region: GIDA; pfam01134 1123523003633 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1123523003634 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1123523003635 active site 1123523003636 DNA binding site [nucleotide binding] 1123523003637 Int/Topo IB signature motif; other site 1123523003638 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1123523003639 active site 1123523003640 HslU subunit interaction site [polypeptide binding]; other site 1123523003641 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1123523003642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523003643 Walker A motif; other site 1123523003644 ATP binding site [chemical binding]; other site 1123523003645 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1123523003646 Walker B motif; other site 1123523003647 arginine finger; other site 1123523003648 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1123523003649 transcriptional repressor CodY; Validated; Region: PRK04158 1123523003650 CodY GAF-like domain; Region: CodY; pfam06018 1123523003651 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1123523003652 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1123523003653 rRNA interaction site [nucleotide binding]; other site 1123523003654 S8 interaction site; other site 1123523003655 putative laminin-1 binding site; other site 1123523003656 elongation factor Ts; Provisional; Region: tsf; PRK09377 1123523003657 UBA/TS-N domain; Region: UBA; pfam00627 1123523003658 Elongation factor TS; Region: EF_TS; pfam00889 1123523003659 Elongation factor TS; Region: EF_TS; pfam00889 1123523003660 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1123523003661 putative nucleotide binding site [chemical binding]; other site 1123523003662 uridine monophosphate binding site [chemical binding]; other site 1123523003663 homohexameric interface [polypeptide binding]; other site 1123523003664 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1123523003665 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1123523003666 hinge region; other site 1123523003667 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1123523003668 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1123523003669 catalytic residue [active] 1123523003670 putative FPP diphosphate binding site; other site 1123523003671 putative FPP binding hydrophobic cleft; other site 1123523003672 dimer interface [polypeptide binding]; other site 1123523003673 putative IPP diphosphate binding site; other site 1123523003674 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1123523003675 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1123523003676 RIP metalloprotease RseP; Region: TIGR00054 1123523003677 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1123523003678 active site 1123523003679 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1123523003680 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1123523003681 protein binding site [polypeptide binding]; other site 1123523003682 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1123523003683 putative substrate binding region [chemical binding]; other site 1123523003684 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1123523003685 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1123523003686 dimer interface [polypeptide binding]; other site 1123523003687 motif 1; other site 1123523003688 active site 1123523003689 motif 2; other site 1123523003690 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1123523003691 putative deacylase active site [active] 1123523003692 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1123523003693 active site 1123523003694 motif 3; other site 1123523003695 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1123523003696 anticodon binding site; other site 1123523003697 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1123523003698 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1123523003699 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1123523003700 generic binding surface II; other site 1123523003701 generic binding surface I; other site 1123523003702 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1123523003703 active site 1123523003704 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1123523003705 active site 1123523003706 catalytic site [active] 1123523003707 substrate binding site [chemical binding]; other site 1123523003708 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1123523003709 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1123523003710 Sm and related proteins; Region: Sm_like; cl00259 1123523003711 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1123523003712 putative oligomer interface [polypeptide binding]; other site 1123523003713 putative RNA binding site [nucleotide binding]; other site 1123523003714 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1123523003715 NusA N-terminal domain; Region: NusA_N; pfam08529 1123523003716 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1123523003717 RNA binding site [nucleotide binding]; other site 1123523003718 homodimer interface [polypeptide binding]; other site 1123523003719 NusA-like KH domain; Region: KH_5; pfam13184 1123523003720 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1123523003721 G-X-X-G motif; other site 1123523003722 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1123523003723 putative RNA binding cleft [nucleotide binding]; other site 1123523003724 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1123523003725 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1123523003726 translation initiation factor IF-2; Region: IF-2; TIGR00487 1123523003727 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1123523003728 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1123523003729 G1 box; other site 1123523003730 putative GEF interaction site [polypeptide binding]; other site 1123523003731 GTP/Mg2+ binding site [chemical binding]; other site 1123523003732 Switch I region; other site 1123523003733 G2 box; other site 1123523003734 G3 box; other site 1123523003735 Switch II region; other site 1123523003736 G4 box; other site 1123523003737 G5 box; other site 1123523003738 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1123523003739 Translation-initiation factor 2; Region: IF-2; pfam11987 1123523003740 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1123523003741 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1123523003742 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 1123523003743 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1123523003744 RNA binding site [nucleotide binding]; other site 1123523003745 active site 1123523003746 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1123523003747 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1123523003748 active site 1123523003749 Riboflavin kinase; Region: Flavokinase; smart00904 1123523003750 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1123523003751 16S/18S rRNA binding site [nucleotide binding]; other site 1123523003752 S13e-L30e interaction site [polypeptide binding]; other site 1123523003753 25S rRNA binding site [nucleotide binding]; other site 1123523003754 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1123523003755 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1123523003756 RNase E interface [polypeptide binding]; other site 1123523003757 trimer interface [polypeptide binding]; other site 1123523003758 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1123523003759 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1123523003760 RNase E interface [polypeptide binding]; other site 1123523003761 trimer interface [polypeptide binding]; other site 1123523003762 active site 1123523003763 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1123523003764 putative nucleic acid binding region [nucleotide binding]; other site 1123523003765 G-X-X-G motif; other site 1123523003766 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1123523003767 RNA binding site [nucleotide binding]; other site 1123523003768 domain interface; other site 1123523003769 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1123523003770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1123523003771 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1123523003772 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1123523003773 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1123523003774 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1123523003775 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1123523003776 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1123523003777 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1123523003778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1123523003779 DNA-binding site [nucleotide binding]; DNA binding site 1123523003780 UTRA domain; Region: UTRA; pfam07702 1123523003781 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1123523003782 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1123523003783 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1123523003784 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1123523003785 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1123523003786 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1123523003787 classical (c) SDRs; Region: SDR_c; cd05233 1123523003788 NAD(P) binding site [chemical binding]; other site 1123523003789 active site 1123523003790 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1123523003791 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1123523003792 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1123523003793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523003794 non-specific DNA binding site [nucleotide binding]; other site 1123523003795 salt bridge; other site 1123523003796 sequence-specific DNA binding site [nucleotide binding]; other site 1123523003797 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1123523003798 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1123523003799 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1123523003800 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1123523003801 putative MPT binding site; other site 1123523003802 recombinase A; Provisional; Region: recA; PRK09354 1123523003803 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1123523003804 hexamer interface [polypeptide binding]; other site 1123523003805 Walker A motif; other site 1123523003806 ATP binding site [chemical binding]; other site 1123523003807 Walker B motif; other site 1123523003808 phosphodiesterase; Provisional; Region: PRK12704 1123523003809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1123523003810 Zn2+ binding site [ion binding]; other site 1123523003811 Mg2+ binding site [ion binding]; other site 1123523003812 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1123523003813 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1123523003814 putative active site [active] 1123523003815 metal binding site [ion binding]; metal-binding site 1123523003816 homodimer binding site [polypeptide binding]; other site 1123523003817 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1123523003818 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1123523003819 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1123523003820 dimer interface [polypeptide binding]; other site 1123523003821 PYR/PP interface [polypeptide binding]; other site 1123523003822 TPP binding site [chemical binding]; other site 1123523003823 substrate binding site [chemical binding]; other site 1123523003824 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1123523003825 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1123523003826 TPP-binding site [chemical binding]; other site 1123523003827 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1123523003828 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1123523003829 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1123523003830 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1123523003831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523003832 FeS/SAM binding site; other site 1123523003833 TRAM domain; Region: TRAM; pfam01938 1123523003834 Predicted membrane protein [Function unknown]; Region: COG4550 1123523003835 Predicted membrane protein [Function unknown]; Region: COG4732 1123523003836 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1123523003837 MutS domain I; Region: MutS_I; pfam01624 1123523003838 MutS domain II; Region: MutS_II; pfam05188 1123523003839 MutS domain III; Region: MutS_III; pfam05192 1123523003840 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1123523003841 Walker A/P-loop; other site 1123523003842 ATP binding site [chemical binding]; other site 1123523003843 Q-loop/lid; other site 1123523003844 ABC transporter signature motif; other site 1123523003845 Walker B; other site 1123523003846 D-loop; other site 1123523003847 H-loop/switch region; other site 1123523003848 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1123523003849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523003850 ATP binding site [chemical binding]; other site 1123523003851 Mg2+ binding site [ion binding]; other site 1123523003852 G-X-G motif; other site 1123523003853 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1123523003854 ATP binding site [chemical binding]; other site 1123523003855 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1123523003856 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; pfam04309 1123523003857 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1123523003858 amphipathic channel; other site 1123523003859 Asn-Pro-Ala signature motifs; other site 1123523003860 glycerol kinase; Provisional; Region: glpK; PRK00047 1123523003861 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1123523003862 N- and C-terminal domain interface [polypeptide binding]; other site 1123523003863 active site 1123523003864 MgATP binding site [chemical binding]; other site 1123523003865 catalytic site [active] 1123523003866 metal binding site [ion binding]; metal-binding site 1123523003867 glycerol binding site [chemical binding]; other site 1123523003868 homotetramer interface [polypeptide binding]; other site 1123523003869 homodimer interface [polypeptide binding]; other site 1123523003870 FBP binding site [chemical binding]; other site 1123523003871 protein IIAGlc interface [polypeptide binding]; other site 1123523003872 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1123523003873 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1123523003874 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1123523003875 Cofactor of BRCA1 (COBRA1); Region: COBRA1; pfam06209 1123523003876 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1123523003877 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1123523003878 bacterial Hfq-like; Region: Hfq; cd01716 1123523003879 hexamer interface [polypeptide binding]; other site 1123523003880 Sm1 motif; other site 1123523003881 RNA binding site [nucleotide binding]; other site 1123523003882 Sm2 motif; other site 1123523003883 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1123523003884 catalytic residues [active] 1123523003885 dimer interface [polypeptide binding]; other site 1123523003886 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1123523003887 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1123523003888 HflX GTPase family; Region: HflX; cd01878 1123523003889 G1 box; other site 1123523003890 GTP/Mg2+ binding site [chemical binding]; other site 1123523003891 Switch I region; other site 1123523003892 G2 box; other site 1123523003893 G3 box; other site 1123523003894 Switch II region; other site 1123523003895 G4 box; other site 1123523003896 G5 box; other site 1123523003897 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1123523003898 Aluminium resistance protein; Region: Alum_res; pfam06838 1123523003899 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1123523003900 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1123523003901 DNA binding residues [nucleotide binding] 1123523003902 putative dimer interface [polypeptide binding]; other site 1123523003903 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1123523003904 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1123523003905 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1123523003906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1123523003907 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1123523003908 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1123523003909 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1123523003910 catalytic residue [active] 1123523003911 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1123523003912 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1123523003913 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1123523003914 putative active site [active] 1123523003915 catalytic site [active] 1123523003916 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1123523003917 putative active site [active] 1123523003918 catalytic site [active] 1123523003919 Staphylococcal nuclease homologues; Region: SNc; smart00318 1123523003920 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1123523003921 Catalytic site; other site 1123523003922 AAA domain; Region: AAA_11; pfam13086 1123523003923 aspartate kinase; Reviewed; Region: PRK09034 1123523003924 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1123523003925 putative catalytic residues [active] 1123523003926 putative nucleotide binding site [chemical binding]; other site 1123523003927 putative aspartate binding site [chemical binding]; other site 1123523003928 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1123523003929 allosteric regulatory residue; other site 1123523003930 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1123523003931 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1123523003932 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1123523003933 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1123523003934 threonine synthase; Reviewed; Region: PRK06721 1123523003935 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1123523003936 homodimer interface [polypeptide binding]; other site 1123523003937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523003938 catalytic residue [active] 1123523003939 homoserine kinase; Provisional; Region: PRK01212 1123523003940 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1123523003941 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1123523003942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523003943 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1123523003944 active site 1123523003945 motif I; other site 1123523003946 motif II; other site 1123523003947 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1123523003948 lysine transporter; Provisional; Region: PRK10836 1123523003949 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1123523003950 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1123523003951 tetramer interface [polypeptide binding]; other site 1123523003952 heme binding pocket [chemical binding]; other site 1123523003953 NADPH binding site [chemical binding]; other site 1123523003954 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1123523003955 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1123523003956 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1123523003957 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1123523003958 active site 1123523003959 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1123523003960 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1123523003961 LexA repressor; Validated; Region: PRK00215 1123523003962 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1123523003963 putative DNA binding site [nucleotide binding]; other site 1123523003964 putative Zn2+ binding site [ion binding]; other site 1123523003965 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1123523003966 Catalytic site [active] 1123523003967 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1123523003968 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1123523003969 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1123523003970 TPP-binding site [chemical binding]; other site 1123523003971 dimer interface [polypeptide binding]; other site 1123523003972 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1123523003973 PYR/PP interface [polypeptide binding]; other site 1123523003974 dimer interface [polypeptide binding]; other site 1123523003975 TPP binding site [chemical binding]; other site 1123523003976 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1123523003977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1123523003978 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1123523003979 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1123523003980 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1123523003981 active site 1123523003982 metal binding site [ion binding]; metal-binding site 1123523003983 DNA binding site [nucleotide binding] 1123523003984 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1123523003985 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1123523003986 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1123523003987 Walker A/P-loop; other site 1123523003988 ATP binding site [chemical binding]; other site 1123523003989 Q-loop/lid; other site 1123523003990 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1123523003991 ABC transporter signature motif; other site 1123523003992 Walker B; other site 1123523003993 D-loop; other site 1123523003994 H-loop/switch region; other site 1123523003995 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1123523003996 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13954 1123523003997 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1123523003998 aconitate hydratase; Validated; Region: PRK09277 1123523003999 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1123523004000 substrate binding site [chemical binding]; other site 1123523004001 ligand binding site [chemical binding]; other site 1123523004002 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1123523004003 substrate binding site [chemical binding]; other site 1123523004004 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1123523004005 active site 1123523004006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1123523004007 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1123523004008 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1123523004009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523004010 ATP binding site [chemical binding]; other site 1123523004011 Mg2+ binding site [ion binding]; other site 1123523004012 G-X-G motif; other site 1123523004013 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1123523004014 anchoring element; other site 1123523004015 dimer interface [polypeptide binding]; other site 1123523004016 ATP binding site [chemical binding]; other site 1123523004017 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1123523004018 active site 1123523004019 putative metal-binding site [ion binding]; other site 1123523004020 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1123523004021 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1123523004022 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1123523004023 CAP-like domain; other site 1123523004024 active site 1123523004025 primary dimer interface [polypeptide binding]; other site 1123523004026 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1123523004027 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1123523004028 amino acid carrier protein; Region: agcS; TIGR00835 1123523004029 CAT RNA binding domain; Region: CAT_RBD; smart01061 1123523004030 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1123523004031 PRD domain; Region: PRD; pfam00874 1123523004032 PRD domain; Region: PRD; pfam00874 1123523004033 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1123523004034 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1123523004035 Predicted integral membrane protein [Function unknown]; Region: COG0392 1123523004036 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1123523004037 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1123523004038 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1123523004039 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1123523004040 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1123523004041 active site 1 [active] 1123523004042 dimer interface [polypeptide binding]; other site 1123523004043 hexamer interface [polypeptide binding]; other site 1123523004044 active site 2 [active] 1123523004045 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1123523004046 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1123523004047 active site 1123523004048 DNA binding site [nucleotide binding] 1123523004049 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1123523004050 prephenate dehydrogenase; Validated; Region: PRK06545 1123523004051 prephenate dehydrogenase; Validated; Region: PRK08507 1123523004052 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1123523004053 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1123523004054 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1123523004055 putative oligomer interface [polypeptide binding]; other site 1123523004056 putative active site [active] 1123523004057 metal binding site [ion binding]; metal-binding site 1123523004058 anthranilate synthase component I; Provisional; Region: PRK13567 1123523004059 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1123523004060 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1123523004061 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1123523004062 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1123523004063 glutamine binding [chemical binding]; other site 1123523004064 catalytic triad [active] 1123523004065 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1123523004066 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1123523004067 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1123523004068 active site 1123523004069 ribulose/triose binding site [chemical binding]; other site 1123523004070 phosphate binding site [ion binding]; other site 1123523004071 substrate (anthranilate) binding pocket [chemical binding]; other site 1123523004072 product (indole) binding pocket [chemical binding]; other site 1123523004073 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1123523004074 active site 1123523004075 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1123523004076 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1123523004077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523004078 catalytic residue [active] 1123523004079 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1123523004080 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1123523004081 substrate binding site [chemical binding]; other site 1123523004082 active site 1123523004083 catalytic residues [active] 1123523004084 heterodimer interface [polypeptide binding]; other site 1123523004085 FemAB family; Region: FemAB; pfam02388 1123523004086 FlxA-like protein; Region: FlxA; pfam14282 1123523004087 FemAB family; Region: FemAB; pfam02388 1123523004088 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1123523004089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523004090 active site 1123523004091 motif I; other site 1123523004092 motif II; other site 1123523004093 SWIM zinc finger; Region: SWIM; pfam04434 1123523004094 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1123523004095 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523004096 Walker A/P-loop; other site 1123523004097 ATP binding site [chemical binding]; other site 1123523004098 Q-loop/lid; other site 1123523004099 ABC transporter signature motif; other site 1123523004100 Walker B; other site 1123523004101 D-loop; other site 1123523004102 H-loop/switch region; other site 1123523004103 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523004104 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1123523004105 Walker A/P-loop; other site 1123523004106 ATP binding site [chemical binding]; other site 1123523004107 Q-loop/lid; other site 1123523004108 ABC transporter signature motif; other site 1123523004109 Walker B; other site 1123523004110 D-loop; other site 1123523004111 H-loop/switch region; other site 1123523004112 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1123523004113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523004114 dimer interface [polypeptide binding]; other site 1123523004115 conserved gate region; other site 1123523004116 putative PBP binding loops; other site 1123523004117 ABC-ATPase subunit interface; other site 1123523004118 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1123523004119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523004120 dimer interface [polypeptide binding]; other site 1123523004121 conserved gate region; other site 1123523004122 putative PBP binding loops; other site 1123523004123 ABC-ATPase subunit interface; other site 1123523004124 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 1123523004125 oligoendopeptidase F; Region: pepF; TIGR00181 1123523004126 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 1123523004127 active site 1123523004128 Zn binding site [ion binding]; other site 1123523004129 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1123523004130 PhoU domain; Region: PhoU; pfam01895 1123523004131 PhoU domain; Region: PhoU; pfam01895 1123523004132 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 1123523004133 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1123523004134 Walker A/P-loop; other site 1123523004135 ATP binding site [chemical binding]; other site 1123523004136 Q-loop/lid; other site 1123523004137 ABC transporter signature motif; other site 1123523004138 Walker B; other site 1123523004139 D-loop; other site 1123523004140 H-loop/switch region; other site 1123523004141 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1123523004142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523004143 dimer interface [polypeptide binding]; other site 1123523004144 conserved gate region; other site 1123523004145 putative PBP binding loops; other site 1123523004146 ABC-ATPase subunit interface; other site 1123523004147 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1123523004148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523004149 dimer interface [polypeptide binding]; other site 1123523004150 conserved gate region; other site 1123523004151 ABC-ATPase subunit interface; other site 1123523004152 phosphate binding protein; Region: ptsS_2; TIGR02136 1123523004153 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1123523004154 S1 domain; Region: S1_2; pfam13509 1123523004155 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1123523004156 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523004157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523004158 ABC transporter; Region: ABC_tran_2; pfam12848 1123523004159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523004160 aspartate kinase; Reviewed; Region: PRK06635 1123523004161 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1123523004162 putative nucleotide binding site [chemical binding]; other site 1123523004163 putative catalytic residues [active] 1123523004164 putative Mg ion binding site [ion binding]; other site 1123523004165 putative aspartate binding site [chemical binding]; other site 1123523004166 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 1123523004167 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1123523004168 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1123523004169 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1123523004170 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1123523004171 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1123523004172 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1123523004173 dimer interface [polypeptide binding]; other site 1123523004174 active site 1123523004175 catalytic residue [active] 1123523004176 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1123523004177 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1123523004178 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1123523004179 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1123523004180 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1123523004181 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1123523004182 active site 1123523004183 trimer interface [polypeptide binding]; other site 1123523004184 substrate binding site [chemical binding]; other site 1123523004185 CoA binding site [chemical binding]; other site 1123523004186 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1123523004187 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1123523004188 metal binding site [ion binding]; metal-binding site 1123523004189 dimer interface [polypeptide binding]; other site 1123523004190 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1123523004191 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1123523004192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1123523004193 catalytic residue [active] 1123523004194 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1123523004195 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1123523004196 active site 1123523004197 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1123523004198 substrate binding site [chemical binding]; other site 1123523004199 catalytic residues [active] 1123523004200 dimer interface [polypeptide binding]; other site 1123523004201 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1123523004202 DNA-binding site [nucleotide binding]; DNA binding site 1123523004203 RNA-binding motif; other site 1123523004204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4699 1123523004205 acylphosphatase; Provisional; Region: PRK14431 1123523004206 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1123523004207 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1123523004208 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 1123523004209 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1123523004210 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1123523004211 metal ion-dependent adhesion site (MIDAS); other site 1123523004212 MoxR-like ATPases [General function prediction only]; Region: COG0714 1123523004213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523004214 Walker A motif; other site 1123523004215 ATP binding site [chemical binding]; other site 1123523004216 Walker B motif; other site 1123523004217 arginine finger; other site 1123523004218 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1123523004219 active site 1123523004220 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1123523004221 active site 1123523004222 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1123523004223 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1123523004224 E3 interaction surface; other site 1123523004225 lipoyl attachment site [posttranslational modification]; other site 1123523004226 e3 binding domain; Region: E3_binding; pfam02817 1123523004227 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1123523004228 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1123523004229 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1123523004230 TPP-binding site [chemical binding]; other site 1123523004231 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240 1123523004232 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1123523004233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1123523004234 HAMP domain; Region: HAMP; pfam00672 1123523004235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1123523004236 dimer interface [polypeptide binding]; other site 1123523004237 phosphorylation site [posttranslational modification] 1123523004238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523004239 ATP binding site [chemical binding]; other site 1123523004240 Mg2+ binding site [ion binding]; other site 1123523004241 G-X-G motif; other site 1123523004242 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523004243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523004244 active site 1123523004245 phosphorylation site [posttranslational modification] 1123523004246 intermolecular recognition site; other site 1123523004247 dimerization interface [polypeptide binding]; other site 1123523004248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523004249 DNA binding site [nucleotide binding] 1123523004250 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1123523004251 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1123523004252 active site 1123523004253 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1123523004254 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1123523004255 active site 1123523004256 homodimer interface [polypeptide binding]; other site 1123523004257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523004258 Coenzyme A binding pocket [chemical binding]; other site 1123523004259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1123523004260 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1123523004261 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1123523004262 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1123523004263 protein binding site [polypeptide binding]; other site 1123523004264 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1123523004265 Catalytic dyad [active] 1123523004266 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1123523004267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 1123523004268 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1123523004269 HPr interaction site; other site 1123523004270 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1123523004271 active site 1123523004272 phosphorylation site [posttranslational modification] 1123523004273 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1123523004274 SelR domain; Region: SelR; pfam01641 1123523004275 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1123523004276 EDD domain protein, DegV family; Region: DegV; TIGR00762 1123523004277 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1123523004278 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1123523004279 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1123523004280 folate binding site [chemical binding]; other site 1123523004281 NADP+ binding site [chemical binding]; other site 1123523004282 thymidylate synthase; Region: thym_sym; TIGR03284 1123523004283 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1123523004284 dimerization interface [polypeptide binding]; other site 1123523004285 active site 1123523004286 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1123523004287 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1123523004288 Virulence factor; Region: Virulence_fact; pfam13769 1123523004289 HEAT repeats; Region: HEAT_2; pfam13646 1123523004290 HEAT repeat; Region: HEAT; pfam02985 1123523004291 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1123523004292 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1123523004293 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1123523004294 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1123523004295 RNA/DNA hybrid binding site [nucleotide binding]; other site 1123523004296 active site 1123523004297 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523004298 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1123523004299 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1123523004300 GA module; Region: GA; smart00844 1123523004301 GA module; Region: GA; smart00844 1123523004302 GA module; Region: GA; smart00844 1123523004303 GA module; Region: GA; smart00844 1123523004304 GA module; Region: GA; smart00844 1123523004305 GA module; Region: GA; smart00844 1123523004306 GA module; Region: GA; smart00844 1123523004307 GA module; Region: GA; smart00844 1123523004308 GA module; Region: GA; smart00844 1123523004309 GA module; Region: GA; smart00844 1123523004310 GA module; Region: GA; smart00844 1123523004311 GA module; Region: GA; smart00844 1123523004312 GA module; Region: GA; smart00844 1123523004313 GA module; Region: GA; smart00844 1123523004314 GA module; Region: GA; pfam01468 1123523004315 GA module; Region: GA; smart00844 1123523004316 GA module; Region: GA; smart00844 1123523004317 GA module; Region: GA; smart00844 1123523004318 GA module; Region: GA; smart00844 1123523004319 GA module; Region: GA; smart00844 1123523004320 GA module; Region: GA; smart00844 1123523004321 GA module; Region: GA; smart00844 1123523004322 GA module; Region: GA; smart00844 1123523004323 GA module; Region: GA; smart00844 1123523004324 GA module; Region: GA; smart00844 1123523004325 GA module; Region: GA; pfam01468 1123523004326 GA module; Region: GA; smart00844 1123523004327 GA module; Region: GA; smart00844 1123523004328 GA module; Region: GA; smart00844 1123523004329 GA module; Region: GA; smart00844 1123523004330 GA module; Region: GA; pfam01468 1123523004331 GA module; Region: GA; smart00844 1123523004332 GA module; Region: GA; smart00844 1123523004333 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1123523004334 GA module; Region: GA; smart00844 1123523004335 GA module; Region: GA; smart00844 1123523004336 GA module; Region: GA; smart00844 1123523004337 GA module; Region: GA; smart00844 1123523004338 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1123523004339 GA module; Region: GA; smart00844 1123523004340 GA module; Region: GA; smart00844 1123523004341 GA module; Region: GA; pfam01468 1123523004342 GA module; Region: GA; smart00844 1123523004343 GA module; Region: GA; smart00844 1123523004344 GA module; Region: GA; smart00844 1123523004345 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523004346 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523004347 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1123523004348 Amino acid permease; Region: AA_permease_2; pfam13520 1123523004349 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1123523004350 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1123523004351 tetramer interface [polypeptide binding]; other site 1123523004352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523004353 catalytic residue [active] 1123523004354 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1123523004355 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1123523004356 hexamer interface [polypeptide binding]; other site 1123523004357 ligand binding site [chemical binding]; other site 1123523004358 putative active site [active] 1123523004359 NAD(P) binding site [chemical binding]; other site 1123523004360 5'-3' exonuclease; Region: 53EXOc; smart00475 1123523004361 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1123523004362 active site 1123523004363 metal binding site 1 [ion binding]; metal-binding site 1123523004364 putative 5' ssDNA interaction site; other site 1123523004365 metal binding site 3; metal-binding site 1123523004366 metal binding site 2 [ion binding]; metal-binding site 1123523004367 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1123523004368 putative DNA binding site [nucleotide binding]; other site 1123523004369 putative metal binding site [ion binding]; other site 1123523004370 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1123523004371 Dynamin family; Region: Dynamin_N; pfam00350 1123523004372 G1 box; other site 1123523004373 GTP/Mg2+ binding site [chemical binding]; other site 1123523004374 G2 box; other site 1123523004375 Switch I region; other site 1123523004376 G3 box; other site 1123523004377 Switch II region; other site 1123523004378 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1123523004379 G4 box; other site 1123523004380 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1123523004381 Dynamin family; Region: Dynamin_N; pfam00350 1123523004382 G1 box; other site 1123523004383 GTP/Mg2+ binding site [chemical binding]; other site 1123523004384 G2 box; other site 1123523004385 Switch I region; other site 1123523004386 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1123523004387 G3 box; other site 1123523004388 Switch II region; other site 1123523004389 GTP/Mg2+ binding site [chemical binding]; other site 1123523004390 G4 box; other site 1123523004391 G5 box; other site 1123523004392 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1123523004393 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1123523004394 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1123523004395 Cobalt transport protein component CbiN; Region: CbiN; cl00842 1123523004396 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1123523004397 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1123523004398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1123523004399 cell division protein GpsB; Provisional; Region: PRK14127 1123523004400 DivIVA domain; Region: DivI1A_domain; TIGR03544 1123523004401 hypothetical protein; Provisional; Region: PRK13660 1123523004402 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1123523004403 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1123523004404 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1123523004405 Transglycosylase; Region: Transgly; pfam00912 1123523004406 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1123523004407 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1123523004408 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1123523004409 minor groove reading motif; other site 1123523004410 helix-hairpin-helix signature motif; other site 1123523004411 substrate binding pocket [chemical binding]; other site 1123523004412 active site 1123523004413 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1123523004414 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1123523004415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1123523004416 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1123523004417 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1123523004418 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1123523004419 putative dimer interface [polypeptide binding]; other site 1123523004420 putative anticodon binding site; other site 1123523004421 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1123523004422 homodimer interface [polypeptide binding]; other site 1123523004423 motif 1; other site 1123523004424 motif 2; other site 1123523004425 active site 1123523004426 motif 3; other site 1123523004427 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1123523004428 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1123523004429 active site 1123523004430 catalytic site [active] 1123523004431 substrate binding site [chemical binding]; other site 1123523004432 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1123523004433 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1123523004434 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1123523004435 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1123523004436 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1123523004437 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1123523004438 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1123523004439 active site 1123523004440 NTP binding site [chemical binding]; other site 1123523004441 metal binding triad [ion binding]; metal-binding site 1123523004442 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1123523004443 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1123523004444 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1123523004445 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1123523004446 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1123523004447 homodimer interface [polypeptide binding]; other site 1123523004448 metal binding site [ion binding]; metal-binding site 1123523004449 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1123523004450 Predicted membrane protein [Function unknown]; Region: COG4347 1123523004451 Uncharacterized conserved protein [Function unknown]; Region: COG5582 1123523004452 UPF0302 domain; Region: UPF0302; pfam08864 1123523004453 A short protein domain of unknown function; Region: IDEAL; smart00914 1123523004454 TPR repeat; Region: TPR_11; pfam13414 1123523004455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1123523004456 binding surface 1123523004457 TPR motif; other site 1123523004458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1123523004459 TPR motif; other site 1123523004460 binding surface 1123523004461 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1123523004462 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1123523004463 hinge; other site 1123523004464 active site 1123523004465 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1123523004466 active site 1123523004467 NAD binding site [chemical binding]; other site 1123523004468 metal binding site [ion binding]; metal-binding site 1123523004469 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1123523004470 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1123523004471 Tetramer interface [polypeptide binding]; other site 1123523004472 active site 1123523004473 FMN-binding site [chemical binding]; other site 1123523004474 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1123523004475 active site 1123523004476 multimer interface [polypeptide binding]; other site 1123523004477 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1123523004478 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1123523004479 substrate binding pocket [chemical binding]; other site 1123523004480 chain length determination region; other site 1123523004481 substrate-Mg2+ binding site; other site 1123523004482 catalytic residues [active] 1123523004483 aspartate-rich region 1; other site 1123523004484 active site lid residues [active] 1123523004485 aspartate-rich region 2; other site 1123523004486 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1123523004487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523004488 S-adenosylmethionine binding site [chemical binding]; other site 1123523004489 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1123523004490 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1123523004491 IHF dimer interface [polypeptide binding]; other site 1123523004492 IHF - DNA interface [nucleotide binding]; other site 1123523004493 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1123523004494 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1123523004495 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1123523004496 GTP-binding protein Der; Reviewed; Region: PRK00093 1123523004497 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1123523004498 G1 box; other site 1123523004499 GTP/Mg2+ binding site [chemical binding]; other site 1123523004500 Switch I region; other site 1123523004501 G2 box; other site 1123523004502 Switch II region; other site 1123523004503 G3 box; other site 1123523004504 G4 box; other site 1123523004505 G5 box; other site 1123523004506 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1123523004507 G1 box; other site 1123523004508 GTP/Mg2+ binding site [chemical binding]; other site 1123523004509 Switch I region; other site 1123523004510 G2 box; other site 1123523004511 G3 box; other site 1123523004512 Switch II region; other site 1123523004513 G4 box; other site 1123523004514 G5 box; other site 1123523004515 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1123523004516 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1123523004517 RNA binding site [nucleotide binding]; other site 1123523004518 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1123523004519 RNA binding site [nucleotide binding]; other site 1123523004520 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1123523004521 RNA binding site [nucleotide binding]; other site 1123523004522 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1123523004523 RNA binding site [nucleotide binding]; other site 1123523004524 cytidylate kinase; Provisional; Region: cmk; PRK00023 1123523004525 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1123523004526 CMP-binding site; other site 1123523004527 The sites determining sugar specificity; other site 1123523004528 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1123523004529 active site 1123523004530 homotetramer interface [polypeptide binding]; other site 1123523004531 homodimer interface [polypeptide binding]; other site 1123523004532 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1123523004533 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1123523004534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523004535 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1123523004536 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1123523004537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523004538 ATP binding site [chemical binding]; other site 1123523004539 putative Mg++ binding site [ion binding]; other site 1123523004540 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1123523004541 nucleotide binding region [chemical binding]; other site 1123523004542 ATP-binding site [chemical binding]; other site 1123523004543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1123523004544 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1123523004545 Predicted membrane protein [Function unknown]; Region: COG3601 1123523004546 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1123523004547 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1123523004548 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1123523004549 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1123523004550 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1123523004551 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1123523004552 CHAP domain; Region: CHAP; pfam05257 1123523004553 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1123523004554 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1123523004555 active site 1123523004556 metal binding site [ion binding]; metal-binding site 1123523004557 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1123523004558 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1123523004559 Protein of unknown function (DUF2951); Region: DUF2951; pfam11166 1123523004560 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1123523004561 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 1123523004562 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1123523004563 hypothetical protein; Provisional; Region: PRK05926 1123523004564 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1123523004565 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1123523004566 Phage tail protein; Region: Sipho_tail; pfam05709 1123523004567 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 1123523004568 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1123523004569 linker region; other site 1123523004570 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1123523004571 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 1123523004572 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1123523004573 Peptidase family M23; Region: Peptidase_M23; pfam01551 1123523004574 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1123523004575 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1123523004576 catalytic residue [active] 1123523004577 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1123523004578 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1123523004579 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1123523004580 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1123523004581 oligomerization interface [polypeptide binding]; other site 1123523004582 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1123523004583 Phage capsid family; Region: Phage_capsid; pfam05065 1123523004584 Clp protease; Region: CLP_protease; pfam00574 1123523004585 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1123523004586 oligomer interface [polypeptide binding]; other site 1123523004587 active site residues [active] 1123523004588 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1123523004589 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1123523004590 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1123523004591 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1123523004592 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1123523004593 HNH endonuclease; Region: HNH; pfam01844 1123523004594 active site 1123523004595 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1123523004596 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1123523004597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523004598 ATP binding site [chemical binding]; other site 1123523004599 putative Mg++ binding site [ion binding]; other site 1123523004600 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1123523004601 VRR-NUC domain; Region: VRR_NUC; pfam08774 1123523004602 Virulence-associated protein E; Region: VirE; pfam05272 1123523004603 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1123523004604 Transcriptional activator RinB; Region: RinB; pfam06116 1123523004605 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1123523004606 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1123523004607 trimer interface [polypeptide binding]; other site 1123523004608 active site 1123523004609 Protein of unknown function (DUF1024); Region: DUF1024; pfam06260 1123523004610 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1123523004611 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 1123523004612 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 1123523004613 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1123523004614 Protein of unknown function (DUF3113); Region: DUF3113; pfam11310 1123523004615 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 1123523004616 active site 1123523004617 DNA binding site [nucleotide binding] 1123523004618 catalytic site [active] 1123523004619 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1123523004620 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1123523004621 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1123523004622 Homeodomain-like domain; Region: HTH_23; pfam13384 1123523004623 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1123523004624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523004625 non-specific DNA binding site [nucleotide binding]; other site 1123523004626 salt bridge; other site 1123523004627 sequence-specific DNA binding site [nucleotide binding]; other site 1123523004628 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1123523004629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523004630 non-specific DNA binding site [nucleotide binding]; other site 1123523004631 salt bridge; other site 1123523004632 sequence-specific DNA binding site [nucleotide binding]; other site 1123523004633 Domain of unknown function (DUF955); Region: DUF955; cl01076 1123523004634 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 1123523004635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1123523004636 dimerization interface [polypeptide binding]; other site 1123523004637 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1123523004638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1123523004639 dimer interface [polypeptide binding]; other site 1123523004640 phosphorylation site [posttranslational modification] 1123523004641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523004642 ATP binding site [chemical binding]; other site 1123523004643 Mg2+ binding site [ion binding]; other site 1123523004644 G-X-G motif; other site 1123523004645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523004646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523004647 active site 1123523004648 phosphorylation site [posttranslational modification] 1123523004649 intermolecular recognition site; other site 1123523004650 dimerization interface [polypeptide binding]; other site 1123523004651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523004652 DNA binding site [nucleotide binding] 1123523004653 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1123523004654 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1123523004655 RNA binding surface [nucleotide binding]; other site 1123523004656 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1123523004657 active site 1123523004658 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1123523004659 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1123523004660 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1123523004661 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1123523004662 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1123523004663 active site 1123523004664 Int/Topo IB signature motif; other site 1123523004665 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1123523004666 metal binding site 2 [ion binding]; metal-binding site 1123523004667 putative DNA binding helix; other site 1123523004668 metal binding site 1 [ion binding]; metal-binding site 1123523004669 dimer interface [polypeptide binding]; other site 1123523004670 structural Zn2+ binding site [ion binding]; other site 1123523004671 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1123523004672 dimer interface [polypeptide binding]; other site 1123523004673 ADP-ribose binding site [chemical binding]; other site 1123523004674 active site 1123523004675 nudix motif; other site 1123523004676 metal binding site [ion binding]; metal-binding site 1123523004677 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1123523004678 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1123523004679 active site 1123523004680 catalytic tetrad [active] 1123523004681 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1123523004682 classical (c) SDRs; Region: SDR_c; cd05233 1123523004683 NAD(P) binding site [chemical binding]; other site 1123523004684 active site 1123523004685 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1123523004686 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1123523004687 ribonuclease Z; Region: RNase_Z; TIGR02651 1123523004688 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1123523004689 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1123523004690 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1123523004691 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1123523004692 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1123523004693 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1123523004694 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1123523004695 Ca binding site [ion binding]; other site 1123523004696 active site 1123523004697 catalytic site [active] 1123523004698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1123523004699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1123523004700 DNA binding site [nucleotide binding] 1123523004701 domain linker motif; other site 1123523004702 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1123523004703 putative ligand binding site [chemical binding]; other site 1123523004704 putative dimerization interface [polypeptide binding]; other site 1123523004705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1123523004706 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1123523004707 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1123523004708 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1123523004709 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1123523004710 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1123523004711 peptidase T-like protein; Region: PepT-like; TIGR01883 1123523004712 metal binding site [ion binding]; metal-binding site 1123523004713 putative dimer interface [polypeptide binding]; other site 1123523004714 Predicted membrane protein [Function unknown]; Region: COG4129 1123523004715 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1123523004716 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1123523004717 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1123523004718 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1123523004719 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1123523004720 E3 interaction surface; other site 1123523004721 lipoyl attachment site [posttranslational modification]; other site 1123523004722 e3 binding domain; Region: E3_binding; pfam02817 1123523004723 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1123523004724 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1123523004725 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1123523004726 alpha subunit interface [polypeptide binding]; other site 1123523004727 TPP binding site [chemical binding]; other site 1123523004728 heterodimer interface [polypeptide binding]; other site 1123523004729 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1123523004730 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1123523004731 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1123523004732 tetramer interface [polypeptide binding]; other site 1123523004733 TPP-binding site [chemical binding]; other site 1123523004734 heterodimer interface [polypeptide binding]; other site 1123523004735 phosphorylation loop region [posttranslational modification] 1123523004736 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1123523004737 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1123523004738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523004739 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1123523004740 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1123523004741 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1123523004742 Walker A/P-loop; other site 1123523004743 ATP binding site [chemical binding]; other site 1123523004744 Q-loop/lid; other site 1123523004745 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1123523004746 ABC transporter signature motif; other site 1123523004747 Walker B; other site 1123523004748 D-loop; other site 1123523004749 H-loop/switch region; other site 1123523004750 arginine repressor; Provisional; Region: PRK04280 1123523004751 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1123523004752 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1123523004753 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1123523004754 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1123523004755 substrate binding pocket [chemical binding]; other site 1123523004756 chain length determination region; other site 1123523004757 substrate-Mg2+ binding site; other site 1123523004758 catalytic residues [active] 1123523004759 aspartate-rich region 1; other site 1123523004760 active site lid residues [active] 1123523004761 aspartate-rich region 2; other site 1123523004762 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14068 1123523004763 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1123523004764 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1123523004765 generic binding surface II; other site 1123523004766 generic binding surface I; other site 1123523004767 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1123523004768 putative RNA binding site [nucleotide binding]; other site 1123523004769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1123523004770 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1123523004771 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1123523004772 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1123523004773 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1123523004774 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1123523004775 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1123523004776 carboxyltransferase (CT) interaction site; other site 1123523004777 biotinylation site [posttranslational modification]; other site 1123523004778 elongation factor P; Validated; Region: PRK00529 1123523004779 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1123523004780 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1123523004781 RNA binding site [nucleotide binding]; other site 1123523004782 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1123523004783 RNA binding site [nucleotide binding]; other site 1123523004784 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1123523004785 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1123523004786 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1123523004787 active site 1123523004788 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1123523004789 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1123523004790 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1123523004791 active site residue [active] 1123523004792 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1123523004793 tetramer interface [polypeptide binding]; other site 1123523004794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523004795 catalytic residue [active] 1123523004796 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1123523004797 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1123523004798 tetramer interface [polypeptide binding]; other site 1123523004799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523004800 catalytic residue [active] 1123523004801 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1123523004802 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1123523004803 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1123523004804 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1123523004805 ADP binding site [chemical binding]; other site 1123523004806 magnesium binding site [ion binding]; other site 1123523004807 putative shikimate binding site; other site 1123523004808 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1123523004809 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1123523004810 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1123523004811 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1123523004812 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1123523004813 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1123523004814 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1123523004815 Type II/IV secretion system protein; Region: T2SE; pfam00437 1123523004816 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1123523004817 Walker A motif; other site 1123523004818 ATP binding site [chemical binding]; other site 1123523004819 Walker B motif; other site 1123523004820 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1123523004821 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1123523004822 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1123523004823 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1123523004824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1123523004825 Rhomboid family; Region: Rhomboid; pfam01694 1123523004826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1123523004827 binding surface 1123523004828 TPR motif; other site 1123523004829 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1123523004830 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1123523004831 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1123523004832 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1123523004833 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1123523004834 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1123523004835 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1123523004836 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1123523004837 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1123523004838 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1123523004839 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1123523004840 metal binding site 2 [ion binding]; metal-binding site 1123523004841 putative DNA binding helix; other site 1123523004842 metal binding site 1 [ion binding]; metal-binding site 1123523004843 dimer interface [polypeptide binding]; other site 1123523004844 structural Zn2+ binding site [ion binding]; other site 1123523004845 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1123523004846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523004847 ABC-ATPase subunit interface; other site 1123523004848 dimer interface [polypeptide binding]; other site 1123523004849 putative PBP binding regions; other site 1123523004850 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1123523004851 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1123523004852 endonuclease IV; Provisional; Region: PRK01060 1123523004853 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1123523004854 AP (apurinic/apyrimidinic) site pocket; other site 1123523004855 DNA interaction; other site 1123523004856 Metal-binding active site; metal-binding site 1123523004857 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1123523004858 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1123523004859 ATP binding site [chemical binding]; other site 1123523004860 Mg++ binding site [ion binding]; other site 1123523004861 motif III; other site 1123523004862 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1123523004863 nucleotide binding region [chemical binding]; other site 1123523004864 ATP-binding site [chemical binding]; other site 1123523004865 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1123523004866 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1123523004867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1123523004868 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1123523004869 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1123523004870 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1123523004871 Family of unknown function (DUF633); Region: DUF633; pfam04816 1123523004872 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1123523004873 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1123523004874 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1123523004875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1123523004876 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1123523004877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1123523004878 DNA binding residues [nucleotide binding] 1123523004879 DNA primase, catalytic core; Region: dnaG; TIGR01391 1123523004880 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1123523004881 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1123523004882 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1123523004883 active site 1123523004884 metal binding site [ion binding]; metal-binding site 1123523004885 interdomain interaction site; other site 1123523004886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1123523004887 FOG: CBS domain [General function prediction only]; Region: COG0517 1123523004888 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1123523004889 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1123523004890 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1123523004891 motif 1; other site 1123523004892 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1123523004893 active site 1123523004894 motif 2; other site 1123523004895 motif 3; other site 1123523004896 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1123523004897 anticodon binding site; other site 1123523004898 DNA repair protein RecO; Region: reco; TIGR00613 1123523004899 Recombination protein O N terminal; Region: RecO_N; pfam11967 1123523004900 Recombination protein O C terminal; Region: RecO_C; pfam02565 1123523004901 GTPase Era; Reviewed; Region: era; PRK00089 1123523004902 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1123523004903 G1 box; other site 1123523004904 GTP/Mg2+ binding site [chemical binding]; other site 1123523004905 Switch I region; other site 1123523004906 G2 box; other site 1123523004907 Switch II region; other site 1123523004908 G3 box; other site 1123523004909 G4 box; other site 1123523004910 G5 box; other site 1123523004911 KH domain; Region: KH_2; pfam07650 1123523004912 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1123523004913 active site 1123523004914 catalytic motif [active] 1123523004915 Zn binding site [ion binding]; other site 1123523004916 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1123523004917 metal-binding heat shock protein; Provisional; Region: PRK00016 1123523004918 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1123523004919 PhoH-like protein; Region: PhoH; pfam02562 1123523004920 hypothetical protein; Provisional; Region: PRK13665 1123523004921 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1123523004922 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1123523004923 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1123523004924 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1123523004925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523004926 FeS/SAM binding site; other site 1123523004927 TRAM domain; Region: TRAM; cl01282 1123523004928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1123523004929 RNA methyltransferase, RsmE family; Region: TIGR00046 1123523004930 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1123523004931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523004932 S-adenosylmethionine binding site [chemical binding]; other site 1123523004933 chaperone protein DnaJ; Provisional; Region: PRK14280 1123523004934 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1123523004935 HSP70 interaction site [polypeptide binding]; other site 1123523004936 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1123523004937 substrate binding site [polypeptide binding]; other site 1123523004938 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1123523004939 Zn binding sites [ion binding]; other site 1123523004940 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1123523004941 dimer interface [polypeptide binding]; other site 1123523004942 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1123523004943 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1123523004944 nucleotide binding site [chemical binding]; other site 1123523004945 NEF interaction site [polypeptide binding]; other site 1123523004946 SBD interface [polypeptide binding]; other site 1123523004947 heat shock protein GrpE; Provisional; Region: PRK14140 1123523004948 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1123523004949 dimer interface [polypeptide binding]; other site 1123523004950 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1123523004951 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1123523004952 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 1123523004953 Tubulin C-terminal domain; Region: Tubulin_C; cl10021 1123523004954 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523004955 FeS/SAM binding site; other site 1123523004956 HemN C-terminal domain; Region: HemN_C; pfam06969 1123523004957 GTP-binding protein LepA; Provisional; Region: PRK05433 1123523004958 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1123523004959 G1 box; other site 1123523004960 putative GEF interaction site [polypeptide binding]; other site 1123523004961 GTP/Mg2+ binding site [chemical binding]; other site 1123523004962 Switch I region; other site 1123523004963 G2 box; other site 1123523004964 G3 box; other site 1123523004965 Switch II region; other site 1123523004966 G4 box; other site 1123523004967 G5 box; other site 1123523004968 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1123523004969 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1123523004970 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1123523004971 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1123523004972 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1123523004973 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1123523004974 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1123523004975 Competence protein; Region: Competence; pfam03772 1123523004976 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1123523004977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1123523004978 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1123523004979 catalytic motif [active] 1123523004980 Zn binding site [ion binding]; other site 1123523004981 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1123523004982 Helix-hairpin-helix motif; Region: HHH; pfam00633 1123523004983 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1123523004984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523004985 S-adenosylmethionine binding site [chemical binding]; other site 1123523004986 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1123523004987 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1123523004988 Zn2+ binding site [ion binding]; other site 1123523004989 Mg2+ binding site [ion binding]; other site 1123523004990 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1123523004991 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1123523004992 active site 1123523004993 (T/H)XGH motif; other site 1123523004994 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1123523004995 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1123523004996 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1123523004997 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1123523004998 shikimate binding site; other site 1123523004999 NAD(P) binding site [chemical binding]; other site 1123523005000 GTPase YqeH; Provisional; Region: PRK13796 1123523005001 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1123523005002 GTP/Mg2+ binding site [chemical binding]; other site 1123523005003 G4 box; other site 1123523005004 G5 box; other site 1123523005005 G1 box; other site 1123523005006 Switch I region; other site 1123523005007 G2 box; other site 1123523005008 G3 box; other site 1123523005009 Switch II region; other site 1123523005010 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1123523005011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523005012 active site 1123523005013 motif I; other site 1123523005014 motif II; other site 1123523005015 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1123523005016 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1123523005017 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 1123523005018 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523005019 Fic family protein [Function unknown]; Region: COG3177 1123523005020 Fic/DOC family; Region: Fic; pfam02661 1123523005021 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1123523005022 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1123523005023 putative active site [active] 1123523005024 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1123523005025 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1123523005026 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1123523005027 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1123523005028 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1123523005029 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1123523005030 carboxyltransferase (CT) interaction site; other site 1123523005031 biotinylation site [posttranslational modification]; other site 1123523005032 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1123523005033 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1123523005034 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1123523005035 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1123523005036 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1123523005037 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1123523005038 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1123523005039 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1123523005040 Sugar specificity; other site 1123523005041 Pyrimidine base specificity; other site 1123523005042 ATP-binding site [chemical binding]; other site 1123523005043 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1123523005044 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1123523005045 Peptidase family U32; Region: Peptidase_U32; pfam01136 1123523005046 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1123523005047 Peptidase family U32; Region: Peptidase_U32; pfam01136 1123523005048 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1123523005049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523005050 S-adenosylmethionine binding site [chemical binding]; other site 1123523005051 hypothetical protein; Provisional; Region: PRK13678 1123523005052 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 1123523005053 hypothetical protein; Provisional; Region: PRK05473 1123523005054 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1123523005055 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1123523005056 motif 1; other site 1123523005057 active site 1123523005058 motif 2; other site 1123523005059 motif 3; other site 1123523005060 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1123523005061 DHHA1 domain; Region: DHHA1; pfam02272 1123523005062 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1123523005063 AAA domain; Region: AAA_30; pfam13604 1123523005064 Family description; Region: UvrD_C_2; pfam13538 1123523005065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1123523005066 binding surface 1123523005067 TPR motif; other site 1123523005068 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1123523005069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1123523005070 binding surface 1123523005071 TPR motif; other site 1123523005072 TPR repeat; Region: TPR_11; pfam13414 1123523005073 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1123523005074 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1123523005075 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1123523005076 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1123523005077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1123523005078 catalytic residue [active] 1123523005079 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1123523005080 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1123523005081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1123523005082 Predicted transcriptional regulator [Transcription]; Region: COG1959 1123523005083 Transcriptional regulator; Region: Rrf2; pfam02082 1123523005084 recombination factor protein RarA; Reviewed; Region: PRK13342 1123523005085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523005086 Walker A motif; other site 1123523005087 ATP binding site [chemical binding]; other site 1123523005088 Walker B motif; other site 1123523005089 arginine finger; other site 1123523005090 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1123523005091 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1123523005092 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1123523005093 putative ATP binding site [chemical binding]; other site 1123523005094 putative substrate interface [chemical binding]; other site 1123523005095 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1123523005096 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1123523005097 dimer interface [polypeptide binding]; other site 1123523005098 anticodon binding site; other site 1123523005099 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1123523005100 homodimer interface [polypeptide binding]; other site 1123523005101 motif 1; other site 1123523005102 active site 1123523005103 motif 2; other site 1123523005104 GAD domain; Region: GAD; pfam02938 1123523005105 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1123523005106 motif 3; other site 1123523005107 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1123523005108 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1123523005109 dimer interface [polypeptide binding]; other site 1123523005110 motif 1; other site 1123523005111 active site 1123523005112 motif 2; other site 1123523005113 motif 3; other site 1123523005114 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1123523005115 anticodon binding site; other site 1123523005116 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1123523005117 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1123523005118 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1123523005119 active site 1123523005120 metal binding site [ion binding]; metal-binding site 1123523005121 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1123523005122 putative active site [active] 1123523005123 dimerization interface [polypeptide binding]; other site 1123523005124 putative tRNAtyr binding site [nucleotide binding]; other site 1123523005125 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1123523005126 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1123523005127 Zn2+ binding site [ion binding]; other site 1123523005128 Mg2+ binding site [ion binding]; other site 1123523005129 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1123523005130 synthetase active site [active] 1123523005131 NTP binding site [chemical binding]; other site 1123523005132 metal binding site [ion binding]; metal-binding site 1123523005133 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1123523005134 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1123523005135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1123523005136 active site 1123523005137 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1123523005138 DHH family; Region: DHH; pfam01368 1123523005139 DHHA1 domain; Region: DHHA1; pfam02272 1123523005140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1123523005141 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1123523005142 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1123523005143 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1123523005144 Protein export membrane protein; Region: SecD_SecF; pfam02355 1123523005145 Preprotein translocase subunit; Region: YajC; pfam02699 1123523005146 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1123523005147 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1123523005148 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1123523005149 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1123523005150 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1123523005151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523005152 Walker A motif; other site 1123523005153 ATP binding site [chemical binding]; other site 1123523005154 Walker B motif; other site 1123523005155 arginine finger; other site 1123523005156 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1123523005157 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1123523005158 RuvA N terminal domain; Region: RuvA_N; pfam01330 1123523005159 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1123523005160 ACT domain-containing protein [General function prediction only]; Region: PheB; COG4492 1123523005161 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1123523005162 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1123523005163 GTP1/OBG; Region: GTP1_OBG; pfam01018 1123523005164 Obg GTPase; Region: Obg; cd01898 1123523005165 G1 box; other site 1123523005166 GTP/Mg2+ binding site [chemical binding]; other site 1123523005167 Switch I region; other site 1123523005168 G2 box; other site 1123523005169 G3 box; other site 1123523005170 Switch II region; other site 1123523005171 G4 box; other site 1123523005172 G5 box; other site 1123523005173 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1123523005174 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1123523005175 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1123523005176 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1123523005177 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1123523005178 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1123523005179 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1123523005180 rod shape-determining protein MreC; Region: MreC; pfam04085 1123523005181 hypothetical protein; Reviewed; Region: PRK00024 1123523005182 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1123523005183 MPN+ (JAMM) motif; other site 1123523005184 Zinc-binding site [ion binding]; other site 1123523005185 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1123523005186 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1123523005187 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1123523005188 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1123523005189 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1123523005190 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1123523005191 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1123523005192 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1123523005193 active site 1123523005194 HIGH motif; other site 1123523005195 nucleotide binding site [chemical binding]; other site 1123523005196 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1123523005197 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1123523005198 active site 1123523005199 KMSKS motif; other site 1123523005200 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1123523005201 tRNA binding surface [nucleotide binding]; other site 1123523005202 anticodon binding site; other site 1123523005203 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1123523005204 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1123523005205 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1123523005206 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1123523005207 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1123523005208 inhibitor-cofactor binding pocket; inhibition site 1123523005209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523005210 catalytic residue [active] 1123523005211 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1123523005212 dimer interface [polypeptide binding]; other site 1123523005213 active site 1123523005214 Schiff base residues; other site 1123523005215 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1123523005216 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1123523005217 active site 1123523005218 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1123523005219 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1123523005220 domain interfaces; other site 1123523005221 active site 1123523005222 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmC; COG0755 1123523005223 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1123523005224 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1123523005225 tRNA; other site 1123523005226 putative tRNA binding site [nucleotide binding]; other site 1123523005227 putative NADP binding site [chemical binding]; other site 1123523005228 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1123523005229 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1123523005230 G1 box; other site 1123523005231 GTP/Mg2+ binding site [chemical binding]; other site 1123523005232 Switch I region; other site 1123523005233 G2 box; other site 1123523005234 G3 box; other site 1123523005235 Switch II region; other site 1123523005236 G4 box; other site 1123523005237 G5 box; other site 1123523005238 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1123523005239 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1123523005240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523005241 Walker A motif; other site 1123523005242 ATP binding site [chemical binding]; other site 1123523005243 Walker B motif; other site 1123523005244 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1123523005245 trigger factor; Provisional; Region: tig; PRK01490 1123523005246 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1123523005247 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1123523005248 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1123523005249 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1123523005250 23S rRNA binding site [nucleotide binding]; other site 1123523005251 L21 binding site [polypeptide binding]; other site 1123523005252 L13 binding site [polypeptide binding]; other site 1123523005253 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1123523005254 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1123523005255 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1123523005256 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1123523005257 lysine transporter; Provisional; Region: PRK10836 1123523005258 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1123523005259 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1123523005260 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1123523005261 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1123523005262 active site 1123523005263 dimer interface [polypeptide binding]; other site 1123523005264 motif 1; other site 1123523005265 motif 2; other site 1123523005266 motif 3; other site 1123523005267 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1123523005268 anticodon binding site; other site 1123523005269 primosomal protein DnaI; Reviewed; Region: PRK08939 1123523005270 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1123523005271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523005272 Walker A motif; other site 1123523005273 ATP binding site [chemical binding]; other site 1123523005274 Walker B motif; other site 1123523005275 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1123523005276 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1123523005277 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1123523005278 ATP cone domain; Region: ATP-cone; pfam03477 1123523005279 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1123523005280 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1123523005281 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1123523005282 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1123523005283 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1123523005284 CoA-binding site [chemical binding]; other site 1123523005285 ATP-binding [chemical binding]; other site 1123523005286 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1123523005287 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1123523005288 DNA binding site [nucleotide binding] 1123523005289 catalytic residue [active] 1123523005290 H2TH interface [polypeptide binding]; other site 1123523005291 putative catalytic residues [active] 1123523005292 turnover-facilitating residue; other site 1123523005293 intercalation triad [nucleotide binding]; other site 1123523005294 8OG recognition residue [nucleotide binding]; other site 1123523005295 putative reading head residues; other site 1123523005296 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1123523005297 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1123523005298 DNA polymerase I; Provisional; Region: PRK05755 1123523005299 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1123523005300 active site 1123523005301 metal binding site 1 [ion binding]; metal-binding site 1123523005302 putative 5' ssDNA interaction site; other site 1123523005303 metal binding site 3; metal-binding site 1123523005304 metal binding site 2 [ion binding]; metal-binding site 1123523005305 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1123523005306 putative DNA binding site [nucleotide binding]; other site 1123523005307 putative metal binding site [ion binding]; other site 1123523005308 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1123523005309 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1123523005310 active site 1123523005311 DNA binding site [nucleotide binding] 1123523005312 catalytic site [active] 1123523005313 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1123523005314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1123523005315 dimer interface [polypeptide binding]; other site 1123523005316 phosphorylation site [posttranslational modification] 1123523005317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523005318 ATP binding site [chemical binding]; other site 1123523005319 Mg2+ binding site [ion binding]; other site 1123523005320 G-X-G motif; other site 1123523005321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523005322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523005323 active site 1123523005324 phosphorylation site [posttranslational modification] 1123523005325 intermolecular recognition site; other site 1123523005326 dimerization interface [polypeptide binding]; other site 1123523005327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523005328 DNA binding site [nucleotide binding] 1123523005329 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1123523005330 isocitrate dehydrogenase; Validated; Region: PRK07362 1123523005331 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1123523005332 dimer interface [polypeptide binding]; other site 1123523005333 Citrate synthase; Region: Citrate_synt; pfam00285 1123523005334 active site 1123523005335 citrylCoA binding site [chemical binding]; other site 1123523005336 oxalacetate/citrate binding site [chemical binding]; other site 1123523005337 coenzyme A binding site [chemical binding]; other site 1123523005338 catalytic triad [active] 1123523005339 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1123523005340 pyruvate kinase; Provisional; Region: PRK06354 1123523005341 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1123523005342 domain interfaces; other site 1123523005343 active site 1123523005344 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1123523005345 6-phosphofructokinase; Provisional; Region: PRK03202 1123523005346 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1123523005347 active site 1123523005348 ADP/pyrophosphate binding site [chemical binding]; other site 1123523005349 dimerization interface [polypeptide binding]; other site 1123523005350 allosteric effector site; other site 1123523005351 fructose-1,6-bisphosphate binding site; other site 1123523005352 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1123523005353 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1123523005354 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1123523005355 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1123523005356 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1123523005357 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1123523005358 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1123523005359 putative NAD(P) binding site [chemical binding]; other site 1123523005360 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1123523005361 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1123523005362 active site 1123523005363 PHP Thumb interface [polypeptide binding]; other site 1123523005364 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1123523005365 generic binding surface I; other site 1123523005366 generic binding surface II; other site 1123523005367 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1123523005368 DHH family; Region: DHH; pfam01368 1123523005369 DHHA1 domain; Region: DHHA1; pfam02272 1123523005370 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1123523005371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1123523005372 DNA-binding site [nucleotide binding]; DNA binding site 1123523005373 DRTGG domain; Region: DRTGG; pfam07085 1123523005374 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1123523005375 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1123523005376 active site 2 [active] 1123523005377 active site 1 [active] 1123523005378 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1123523005379 Ligand Binding Site [chemical binding]; other site 1123523005380 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1123523005381 metal-dependent hydrolase; Provisional; Region: PRK00685 1123523005382 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1123523005383 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1123523005384 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1123523005385 active site 1123523005386 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1123523005387 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1123523005388 hexamer interface [polypeptide binding]; other site 1123523005389 ligand binding site [chemical binding]; other site 1123523005390 putative active site [active] 1123523005391 NAD(P) binding site [chemical binding]; other site 1123523005392 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1123523005393 Ligand Binding Site [chemical binding]; other site 1123523005394 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1123523005395 propionate/acetate kinase; Provisional; Region: PRK12379 1123523005396 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1123523005397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523005398 S-adenosylmethionine binding site [chemical binding]; other site 1123523005399 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1123523005400 dimer interface [polypeptide binding]; other site 1123523005401 catalytic triad [active] 1123523005402 peroxidatic and resolving cysteines [active] 1123523005403 hypothetical protein; Provisional; Region: PRK10621 1123523005404 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1123523005405 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1123523005406 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1123523005407 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1123523005408 Ligand Binding Site [chemical binding]; other site 1123523005409 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1123523005410 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1123523005411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1123523005412 catalytic residue [active] 1123523005413 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1123523005414 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1123523005415 GAF domain; Region: GAF_2; pfam13185 1123523005416 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1123523005417 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1123523005418 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1123523005419 RNA binding surface [nucleotide binding]; other site 1123523005420 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1123523005421 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1123523005422 active site 1123523005423 catalytic site [active] 1123523005424 OsmC-like protein; Region: OsmC; cl00767 1123523005425 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1123523005426 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1123523005427 catalytic residue [active] 1123523005428 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1123523005429 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1123523005430 ligand binding site [chemical binding]; other site 1123523005431 NAD binding site [chemical binding]; other site 1123523005432 dimerization interface [polypeptide binding]; other site 1123523005433 catalytic site [active] 1123523005434 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1123523005435 putative L-serine binding site [chemical binding]; other site 1123523005436 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1123523005437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523005438 motif II; other site 1123523005439 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1123523005440 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1123523005441 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1123523005442 active site turn [active] 1123523005443 phosphorylation site [posttranslational modification] 1123523005444 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1123523005445 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1123523005446 putative acyl-acceptor binding pocket; other site 1123523005447 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1123523005448 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1123523005449 protein binding site [polypeptide binding]; other site 1123523005450 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1123523005451 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1123523005452 active site 1123523005453 HIGH motif; other site 1123523005454 dimer interface [polypeptide binding]; other site 1123523005455 KMSKS motif; other site 1123523005456 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1123523005457 RNA binding surface [nucleotide binding]; other site 1123523005458 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1123523005459 Transglycosylase; Region: Transgly; pfam00912 1123523005460 haptoglobin-binding heme uptake protein HarA; Region: IsdH_HarA; TIGR03658 1123523005461 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1123523005462 NEAr Transporter domain; Region: NEAT; smart00725 1123523005463 NEAr Transporter domain; Region: NEAT; smart00725 1123523005464 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1123523005465 heme-binding site [chemical binding]; other site 1123523005466 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1123523005467 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1123523005468 Potassium binding sites [ion binding]; other site 1123523005469 Cesium cation binding sites [ion binding]; other site 1123523005470 acetyl-CoA synthetase; Provisional; Region: PRK04319 1123523005471 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1123523005472 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1123523005473 active site 1123523005474 acyl-activating enzyme (AAE) consensus motif; other site 1123523005475 putative CoA binding site [chemical binding]; other site 1123523005476 AMP binding site [chemical binding]; other site 1123523005477 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1123523005478 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1123523005479 active site 1123523005480 Zn binding site [ion binding]; other site 1123523005481 catabolite control protein A; Region: ccpA; TIGR01481 1123523005482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1123523005483 DNA binding site [nucleotide binding] 1123523005484 domain linker motif; other site 1123523005485 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1123523005486 dimerization interface [polypeptide binding]; other site 1123523005487 effector binding site; other site 1123523005488 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1123523005489 Chorismate mutase type II; Region: CM_2; cl00693 1123523005490 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1123523005491 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1123523005492 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1123523005493 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1123523005494 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1123523005495 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1123523005496 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1123523005497 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1123523005498 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1123523005499 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1123523005500 putative tRNA-binding site [nucleotide binding]; other site 1123523005501 hypothetical protein; Provisional; Region: PRK13668 1123523005502 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1123523005503 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1123523005504 catalytic residues [active] 1123523005505 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1123523005506 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1123523005507 oligomer interface [polypeptide binding]; other site 1123523005508 active site 1123523005509 metal binding site [ion binding]; metal-binding site 1123523005510 Predicted small secreted protein [Function unknown]; Region: COG5584 1123523005511 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1123523005512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523005513 S-adenosylmethionine binding site [chemical binding]; other site 1123523005514 Phosphotransferase enzyme family; Region: APH; pfam01636 1123523005515 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1123523005516 active site 1123523005517 substrate binding site [chemical binding]; other site 1123523005518 ATP binding site [chemical binding]; other site 1123523005519 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1123523005520 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1123523005521 homodimer interface [polypeptide binding]; other site 1123523005522 substrate-cofactor binding pocket; other site 1123523005523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523005524 catalytic residue [active] 1123523005525 dipeptidase PepV; Reviewed; Region: PRK07318 1123523005526 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1123523005527 active site 1123523005528 metal binding site [ion binding]; metal-binding site 1123523005529 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1123523005530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1123523005531 RNA binding surface [nucleotide binding]; other site 1123523005532 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1123523005533 active site 1123523005534 uracil binding [chemical binding]; other site 1123523005535 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1123523005536 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1123523005537 HI0933-like protein; Region: HI0933_like; pfam03486 1123523005538 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523005539 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1123523005540 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005541 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005542 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005543 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005544 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005545 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005546 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005547 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005548 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005549 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005550 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005551 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005552 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005553 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005554 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005555 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523005556 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1123523005557 active site residue [active] 1123523005558 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1123523005559 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1123523005560 HIGH motif; other site 1123523005561 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1123523005562 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1123523005563 active site 1123523005564 KMSKS motif; other site 1123523005565 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1123523005566 tRNA binding surface [nucleotide binding]; other site 1123523005567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523005568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523005569 putative substrate translocation pore; other site 1123523005570 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1123523005571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523005572 S-adenosylmethionine binding site [chemical binding]; other site 1123523005573 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523005574 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1123523005575 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1123523005576 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1123523005577 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1123523005578 homopentamer interface [polypeptide binding]; other site 1123523005579 active site 1123523005580 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1123523005581 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1123523005582 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1123523005583 dimerization interface [polypeptide binding]; other site 1123523005584 active site 1123523005585 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1123523005586 Lumazine binding domain; Region: Lum_binding; pfam00677 1123523005587 Lumazine binding domain; Region: Lum_binding; pfam00677 1123523005588 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1123523005589 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1123523005590 catalytic motif [active] 1123523005591 Zn binding site [ion binding]; other site 1123523005592 RibD C-terminal domain; Region: RibD_C; cl17279 1123523005593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1123523005594 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1123523005595 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1123523005596 arsenical pump membrane protein; Provisional; Region: PRK15445 1123523005597 transmembrane helices; other site 1123523005598 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1123523005599 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1123523005600 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1123523005601 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1123523005602 DNA binding residues [nucleotide binding] 1123523005603 CAAX protease self-immunity; Region: Abi; pfam02517 1123523005604 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1123523005605 active site 1123523005606 intersubunit interactions; other site 1123523005607 catalytic residue [active] 1123523005608 camphor resistance protein CrcB; Provisional; Region: PRK14201 1123523005609 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1123523005610 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1123523005611 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1123523005612 active site 1123523005613 catalytic tetrad [active] 1123523005614 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1123523005615 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1123523005616 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1123523005617 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1123523005618 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1123523005619 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1123523005620 active site 1123523005621 substrate-binding site [chemical binding]; other site 1123523005622 metal-binding site [ion binding] 1123523005623 ATP binding site [chemical binding]; other site 1123523005624 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1123523005625 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1123523005626 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1123523005627 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1123523005628 nudix motif; other site 1123523005629 Haemolytic domain; Region: Haemolytic; pfam01809 1123523005630 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1123523005631 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1123523005632 metal binding site [ion binding]; metal-binding site 1123523005633 substrate binding pocket [chemical binding]; other site 1123523005634 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1123523005635 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1123523005636 acyl-activating enzyme (AAE) consensus motif; other site 1123523005637 putative AMP binding site [chemical binding]; other site 1123523005638 putative active site [active] 1123523005639 putative CoA binding site [chemical binding]; other site 1123523005640 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1123523005641 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1123523005642 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1123523005643 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1123523005644 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1123523005645 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1123523005646 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1123523005647 nucleophilic elbow; other site 1123523005648 catalytic triad; other site 1123523005649 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1123523005650 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1123523005651 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1123523005652 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1123523005653 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1123523005654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523005655 S-adenosylmethionine binding site [chemical binding]; other site 1123523005656 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1123523005657 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1123523005658 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1123523005659 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1123523005660 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1123523005661 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1123523005662 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1123523005663 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1123523005664 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1123523005665 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1123523005666 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1123523005667 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1123523005668 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1123523005669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523005670 Walker A/P-loop; other site 1123523005671 ATP binding site [chemical binding]; other site 1123523005672 Q-loop/lid; other site 1123523005673 ABC transporter signature motif; other site 1123523005674 Walker B; other site 1123523005675 D-loop; other site 1123523005676 H-loop/switch region; other site 1123523005677 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 1123523005678 active site 1123523005679 catalytic triad [active] 1123523005680 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1123523005681 Flavoprotein; Region: Flavoprotein; pfam02441 1123523005682 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1123523005683 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 1123523005684 active site 1123523005685 zinc binding site [ion binding]; other site 1123523005686 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1123523005687 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1123523005688 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1123523005689 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 1123523005690 beta-channel forming cytolysin; Region: hlyII; TIGR01002 1123523005691 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1123523005692 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1123523005693 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 1123523005694 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1123523005695 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1123523005696 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1123523005697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1123523005698 ferrochelatase; Provisional; Region: PRK12435 1123523005699 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1123523005700 C-terminal domain interface [polypeptide binding]; other site 1123523005701 active site 1123523005702 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1123523005703 active site 1123523005704 N-terminal domain interface [polypeptide binding]; other site 1123523005705 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1123523005706 substrate binding site [chemical binding]; other site 1123523005707 active site 1123523005708 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1123523005709 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1123523005710 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1123523005711 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1123523005712 Walker A/P-loop; other site 1123523005713 ATP binding site [chemical binding]; other site 1123523005714 Q-loop/lid; other site 1123523005715 ABC transporter signature motif; other site 1123523005716 Walker B; other site 1123523005717 D-loop; other site 1123523005718 H-loop/switch region; other site 1123523005719 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1123523005720 HIT family signature motif; other site 1123523005721 catalytic residue [active] 1123523005722 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1123523005723 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1123523005724 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1123523005725 SurA N-terminal domain; Region: SurA_N_3; cl07813 1123523005726 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1123523005727 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1123523005728 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1123523005729 generic binding surface II; other site 1123523005730 generic binding surface I; other site 1123523005731 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1123523005732 Zn2+ binding site [ion binding]; other site 1123523005733 Mg2+ binding site [ion binding]; other site 1123523005734 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1123523005735 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1123523005736 Plant specific eukaryotic initiation factor 4B; Region: eIF-4B; pfam06273 1123523005737 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1123523005738 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1123523005739 active site 1123523005740 metal binding site [ion binding]; metal-binding site 1123523005741 DNA binding site [nucleotide binding] 1123523005742 hypothetical protein; Provisional; Region: PRK13676 1123523005743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1123523005744 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1123523005745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523005746 non-specific DNA binding site [nucleotide binding]; other site 1123523005747 salt bridge; other site 1123523005748 sequence-specific DNA binding site [nucleotide binding]; other site 1123523005749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1123523005750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523005751 active site 1123523005752 phosphorylation site [posttranslational modification] 1123523005753 intermolecular recognition site; other site 1123523005754 dimerization interface [polypeptide binding]; other site 1123523005755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1123523005756 DNA binding residues [nucleotide binding] 1123523005757 dimerization interface [polypeptide binding]; other site 1123523005758 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1123523005759 GAF domain; Region: GAF_3; pfam13492 1123523005760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1123523005761 Histidine kinase; Region: HisKA_3; pfam07730 1123523005762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523005763 ATP binding site [chemical binding]; other site 1123523005764 Mg2+ binding site [ion binding]; other site 1123523005765 G-X-G motif; other site 1123523005766 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1123523005767 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1123523005768 active site 1123523005769 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1123523005770 Class II fumarases; Region: Fumarase_classII; cd01362 1123523005771 active site 1123523005772 tetramer interface [polypeptide binding]; other site 1123523005773 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1123523005774 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1123523005775 active site 1123523005776 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1123523005777 epoxyqueuosine reductase; Region: TIGR00276 1123523005778 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1123523005779 HEAT repeats; Region: HEAT_2; pfam13646 1123523005780 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1123523005781 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1123523005782 Walker A/P-loop; other site 1123523005783 ATP binding site [chemical binding]; other site 1123523005784 Q-loop/lid; other site 1123523005785 ABC transporter signature motif; other site 1123523005786 Walker B; other site 1123523005787 D-loop; other site 1123523005788 H-loop/switch region; other site 1123523005789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1123523005790 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1123523005791 substrate binding pocket [chemical binding]; other site 1123523005792 membrane-bound complex binding site; other site 1123523005793 hinge residues; other site 1123523005794 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1123523005795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523005796 dimer interface [polypeptide binding]; other site 1123523005797 conserved gate region; other site 1123523005798 putative PBP binding loops; other site 1123523005799 ABC-ATPase subunit interface; other site 1123523005800 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1123523005801 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1123523005802 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1123523005803 metal binding site 2 [ion binding]; metal-binding site 1123523005804 putative DNA binding helix; other site 1123523005805 metal binding site 1 [ion binding]; metal-binding site 1123523005806 dimer interface [polypeptide binding]; other site 1123523005807 structural Zn2+ binding site [ion binding]; other site 1123523005808 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1123523005809 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1123523005810 putative ligand binding site [chemical binding]; other site 1123523005811 NAD binding site [chemical binding]; other site 1123523005812 catalytic site [active] 1123523005813 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1123523005814 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1123523005815 catalytic triad [active] 1123523005816 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1123523005817 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1123523005818 inhibitor-cofactor binding pocket; inhibition site 1123523005819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523005820 catalytic residue [active] 1123523005821 Predicted membrane protein [Function unknown]; Region: COG4129 1123523005822 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1123523005823 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1123523005824 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1123523005825 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1123523005826 Walker A/P-loop; other site 1123523005827 ATP binding site [chemical binding]; other site 1123523005828 Q-loop/lid; other site 1123523005829 ABC transporter signature motif; other site 1123523005830 Walker B; other site 1123523005831 D-loop; other site 1123523005832 H-loop/switch region; other site 1123523005833 hypothetical protein; Provisional; Region: PRK13662 1123523005834 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1123523005835 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1123523005836 minor groove reading motif; other site 1123523005837 helix-hairpin-helix signature motif; other site 1123523005838 substrate binding pocket [chemical binding]; other site 1123523005839 active site 1123523005840 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1123523005841 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1123523005842 DNA binding and oxoG recognition site [nucleotide binding] 1123523005843 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1123523005844 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1123523005845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523005846 Walker A/P-loop; other site 1123523005847 ATP binding site [chemical binding]; other site 1123523005848 Q-loop/lid; other site 1123523005849 ABC transporter signature motif; other site 1123523005850 Walker B; other site 1123523005851 H-loop/switch region; other site 1123523005852 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1123523005853 recombination regulator RecX; Provisional; Region: recX; PRK14135 1123523005854 glycosyltransferase; Provisional; Region: PRK13481 1123523005855 Transglycosylase; Region: Transgly; pfam00912 1123523005856 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1123523005857 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1123523005858 proposed catalytic triad [active] 1123523005859 conserved cys residue [active] 1123523005860 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1123523005861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523005862 FeS/SAM binding site; other site 1123523005863 YfkB-like domain; Region: YfkB; pfam08756 1123523005864 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1123523005865 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1123523005866 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1123523005867 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1123523005868 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1123523005869 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1123523005870 active site 1123523005871 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1123523005872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1123523005873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523005874 active site 1123523005875 phosphorylation site [posttranslational modification] 1123523005876 intermolecular recognition site; other site 1123523005877 dimerization interface [polypeptide binding]; other site 1123523005878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1123523005879 DNA binding residues [nucleotide binding] 1123523005880 dimerization interface [polypeptide binding]; other site 1123523005881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1123523005882 Histidine kinase; Region: HisKA_3; pfam07730 1123523005883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523005884 ATP binding site [chemical binding]; other site 1123523005885 Mg2+ binding site [ion binding]; other site 1123523005886 G-X-G motif; other site 1123523005887 Predicted membrane protein [Function unknown]; Region: COG4758 1123523005888 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1123523005889 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1123523005890 active site 1123523005891 Predicted membrane protein [Function unknown]; Region: COG4129 1123523005892 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1123523005893 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1123523005894 catalytic triad [active] 1123523005895 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1123523005896 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1123523005897 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1123523005898 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1123523005899 Ferritin-like domain; Region: Ferritin; pfam00210 1123523005900 ferroxidase diiron center [ion binding]; other site 1123523005901 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1123523005902 active site 1123523005903 catalytic site [active] 1123523005904 substrate binding site [chemical binding]; other site 1123523005905 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1123523005906 active site 1123523005907 DNA polymerase IV; Validated; Region: PRK02406 1123523005908 DNA binding site [nucleotide binding] 1123523005909 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1123523005910 TRAM domain; Region: TRAM; cl01282 1123523005911 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1123523005912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523005913 S-adenosylmethionine binding site [chemical binding]; other site 1123523005914 putative lipid kinase; Reviewed; Region: PRK13337 1123523005915 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1123523005916 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1123523005917 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1123523005918 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1123523005919 GatB domain; Region: GatB_Yqey; pfam02637 1123523005920 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1123523005921 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1123523005922 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1123523005923 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1123523005924 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1123523005925 Na binding site [ion binding]; other site 1123523005926 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1123523005927 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1123523005928 putative dimer interface [polypeptide binding]; other site 1123523005929 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1123523005930 putative dimer interface [polypeptide binding]; other site 1123523005931 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1123523005932 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1123523005933 nucleotide binding pocket [chemical binding]; other site 1123523005934 K-X-D-G motif; other site 1123523005935 catalytic site [active] 1123523005936 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1123523005937 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1123523005938 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1123523005939 Dimer interface [polypeptide binding]; other site 1123523005940 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1123523005941 Part of AAA domain; Region: AAA_19; pfam13245 1123523005942 Family description; Region: UvrD_C_2; pfam13538 1123523005943 PcrB family; Region: PcrB; pfam01884 1123523005944 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1123523005945 substrate binding site [chemical binding]; other site 1123523005946 putative active site [active] 1123523005947 dimer interface [polypeptide binding]; other site 1123523005948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1123523005949 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1123523005950 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1123523005951 tetramer interface [polypeptide binding]; other site 1123523005952 active site 1123523005953 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1123523005954 Staphopain peptidase C47; Region: Peptidase_C47; pfam05543 1123523005955 NETI protein; Region: NETI; pfam14044 1123523005956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1123523005957 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1123523005958 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1123523005959 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1123523005960 homodimer interface [polypeptide binding]; other site 1123523005961 NAD binding pocket [chemical binding]; other site 1123523005962 ATP binding pocket [chemical binding]; other site 1123523005963 Mg binding site [ion binding]; other site 1123523005964 active-site loop [active] 1123523005965 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1123523005966 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1123523005967 active site 1123523005968 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1123523005969 active site 1123523005970 dimer interface [polypeptide binding]; other site 1123523005971 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1123523005972 Prephenate dehydratase; Region: PDT; pfam00800 1123523005973 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1123523005974 putative L-Phe binding site [chemical binding]; other site 1123523005975 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1123523005976 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1123523005977 transmembrane helices; other site 1123523005978 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1123523005979 Isochorismatase family; Region: Isochorismatase; pfam00857 1123523005980 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1123523005981 catalytic triad [active] 1123523005982 conserved cis-peptide bond; other site 1123523005983 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1123523005984 DHH family; Region: DHH; pfam01368 1123523005985 DHHA2 domain; Region: DHHA2; pfam02833 1123523005986 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1123523005987 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1123523005988 NAD(P) binding site [chemical binding]; other site 1123523005989 catalytic residues [active] 1123523005990 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1123523005991 YolD-like protein; Region: YolD; pfam08863 1123523005992 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 1123523005993 active site 1123523005994 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1123523005995 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1123523005996 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1123523005997 Bacterial PH domain; Region: DUF304; cl01348 1123523005998 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 1123523005999 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1123523006000 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1123523006001 Walker A/P-loop; other site 1123523006002 ATP binding site [chemical binding]; other site 1123523006003 Q-loop/lid; other site 1123523006004 ABC transporter signature motif; other site 1123523006005 Walker B; other site 1123523006006 D-loop; other site 1123523006007 H-loop/switch region; other site 1123523006008 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1123523006009 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1123523006010 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1123523006011 Walker A/P-loop; other site 1123523006012 ATP binding site [chemical binding]; other site 1123523006013 Q-loop/lid; other site 1123523006014 ABC transporter signature motif; other site 1123523006015 Walker B; other site 1123523006016 D-loop; other site 1123523006017 H-loop/switch region; other site 1123523006018 Predicted transcriptional regulators [Transcription]; Region: COG1725 1123523006019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1123523006020 DNA-binding site [nucleotide binding]; DNA binding site 1123523006021 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1123523006022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1123523006023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523006024 homodimer interface [polypeptide binding]; other site 1123523006025 catalytic residue [active] 1123523006026 MAP domain; Region: MAP; pfam03642 1123523006027 MAP domain; Region: MAP; pfam03642 1123523006028 MAP domain; Region: MAP; pfam03642 1123523006029 MAP domain; Region: MAP; pfam03642 1123523006030 MAP domain; Region: MAP; pfam03642 1123523006031 MAP domain; Region: MAP; pfam03642 1123523006032 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1123523006033 Staphylococcal complement inhibitor SCIN; Region: CompInhib_SCIN; pfam11546 1123523006034 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1123523006035 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 1123523006036 CHAP domain; Region: CHAP; pfam05257 1123523006037 Small integral membrane protein [Function unknown]; Region: COG5546 1123523006038 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1123523006039 Ligand-gated ion channel; Region: Lig_chan; pfam00060 1123523006040 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 1123523006041 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1123523006042 Phage tail protein; Region: Sipho_tail; cl17486 1123523006043 Phage tail protein; Region: Sipho_tail; cl17486 1123523006044 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1123523006045 Phage-related protein [Function unknown]; Region: COG5412 1123523006046 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1123523006047 Peptidase family M23; Region: Peptidase_M23; pfam01551 1123523006048 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1123523006049 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1123523006050 catalytic residue [active] 1123523006051 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1123523006052 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1123523006053 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 1123523006054 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1123523006055 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1123523006056 oligomerization interface [polypeptide binding]; other site 1123523006057 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1123523006058 Phage capsid family; Region: Phage_capsid; pfam05065 1123523006059 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1123523006060 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1123523006061 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1123523006062 Phage Terminase; Region: Terminase_1; pfam03354 1123523006063 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1123523006064 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1123523006065 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1123523006066 active site 1123523006067 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1123523006068 putative metal binding site [ion binding]; other site 1123523006069 Protein of unknown function (DUF1514); Region: DUF1514; pfam07438 1123523006070 Transcriptional activator RinB; Region: RinB; pfam06116 1123523006071 Protein of unknown function (DUF1381); Region: DUF1381; pfam07129 1123523006072 dUTPase; Region: dUTPase_2; pfam08761 1123523006073 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1123523006074 active site 1123523006075 homodimer interface [polypeptide binding]; other site 1123523006076 metal binding site [ion binding]; metal-binding site 1123523006077 Phage Conserved Open Reading Frame 51; Region: Phage_Orf51; pfam06194 1123523006078 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1123523006079 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1123523006080 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1123523006081 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1123523006082 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1123523006083 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1123523006084 dimer interface [polypeptide binding]; other site 1123523006085 ssDNA binding site [nucleotide binding]; other site 1123523006086 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1123523006087 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1123523006088 RecT family; Region: RecT; pfam03837 1123523006089 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1123523006090 Protein of unknown function (DUF1108); Region: DUF1108; pfam06531 1123523006091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4707 1123523006092 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 1123523006093 Prophage antirepressor [Transcription]; Region: COG3617 1123523006094 BRO family, N-terminal domain; Region: Bro-N; smart01040 1123523006095 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1123523006096 Protein of unknown function (DUF739); Region: DUF739; pfam05339 1123523006097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523006098 non-specific DNA binding site [nucleotide binding]; other site 1123523006099 salt bridge; other site 1123523006100 sequence-specific DNA binding site [nucleotide binding]; other site 1123523006101 Predicted transcriptional regulator [Transcription]; Region: COG2932 1123523006102 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1123523006103 Catalytic site [active] 1123523006104 HIRAN domain; Region: HIRAN; pfam08797 1123523006105 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1123523006106 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1123523006107 Int/Topo IB signature motif; other site 1123523006108 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1123523006109 putative catalytic site [active] 1123523006110 phosphate binding site [ion binding]; other site 1123523006111 metal binding site A [ion binding]; metal-binding site 1123523006112 metal binding site C [ion binding]; metal-binding site 1123523006113 metal binding site B [ion binding]; metal-binding site 1123523006114 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1123523006115 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1123523006116 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1123523006117 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1123523006118 metal binding site [ion binding]; metal-binding site 1123523006119 dimer interface [polypeptide binding]; other site 1123523006120 Cation transport protein; Region: TrkH; cl17365 1123523006121 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1123523006122 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1123523006123 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1123523006124 ring oligomerisation interface [polypeptide binding]; other site 1123523006125 ATP/Mg binding site [chemical binding]; other site 1123523006126 stacking interactions; other site 1123523006127 hinge regions; other site 1123523006128 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1123523006129 oligomerisation interface [polypeptide binding]; other site 1123523006130 mobile loop; other site 1123523006131 roof hairpin; other site 1123523006132 CAAX protease self-immunity; Region: Abi; pfam02517 1123523006133 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1123523006134 dimer interface [polypeptide binding]; other site 1123523006135 FMN binding site [chemical binding]; other site 1123523006136 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1123523006137 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1123523006138 putative active site [active] 1123523006139 catalytic triad [active] 1123523006140 putative dimer interface [polypeptide binding]; other site 1123523006141 delta-hemolysin; Provisional; Region: PRK14752 1123523006142 Accessory gene regulator B; Region: AgrB; smart00793 1123523006143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523006144 Mg2+ binding site [ion binding]; other site 1123523006145 G-X-G motif; other site 1123523006146 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1123523006147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523006148 active site 1123523006149 phosphorylation site [posttranslational modification] 1123523006150 intermolecular recognition site; other site 1123523006151 dimerization interface [polypeptide binding]; other site 1123523006152 LytTr DNA-binding domain; Region: LytTR; pfam04397 1123523006153 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1123523006154 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1123523006155 putative substrate binding site [chemical binding]; other site 1123523006156 putative ATP binding site [chemical binding]; other site 1123523006157 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1123523006158 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1123523006159 substrate binding [chemical binding]; other site 1123523006160 active site 1123523006161 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1123523006162 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1123523006163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1123523006164 DNA binding site [nucleotide binding] 1123523006165 domain linker motif; other site 1123523006166 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1123523006167 dimerization interface [polypeptide binding]; other site 1123523006168 ligand binding site [chemical binding]; other site 1123523006169 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1123523006170 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1123523006171 CPxP motif; other site 1123523006172 Predicted transporter component [General function prediction only]; Region: COG2391 1123523006173 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1123523006174 Sulphur transport; Region: Sulf_transp; pfam04143 1123523006175 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 1123523006176 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1123523006177 CoA binding domain; Region: CoA_binding; pfam02629 1123523006178 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1123523006179 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523006180 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523006181 ABC transporter; Region: ABC_tran_2; pfam12848 1123523006182 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1123523006183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1123523006184 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1123523006185 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 1123523006186 Walker A/P-loop; other site 1123523006187 ATP binding site [chemical binding]; other site 1123523006188 Q-loop/lid; other site 1123523006189 ABC transporter signature motif; other site 1123523006190 Walker B; other site 1123523006191 D-loop; other site 1123523006192 H-loop/switch region; other site 1123523006193 UGMP family protein; Validated; Region: PRK09604 1123523006194 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1123523006195 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1123523006196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523006197 Coenzyme A binding pocket [chemical binding]; other site 1123523006198 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1123523006199 Glycoprotease family; Region: Peptidase_M22; pfam00814 1123523006200 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1123523006201 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1123523006202 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1123523006203 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1123523006204 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1123523006205 PYR/PP interface [polypeptide binding]; other site 1123523006206 dimer interface [polypeptide binding]; other site 1123523006207 TPP binding site [chemical binding]; other site 1123523006208 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1123523006209 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1123523006210 TPP-binding site [chemical binding]; other site 1123523006211 dimer interface [polypeptide binding]; other site 1123523006212 acetolactate synthase 1 regulatory subunit; Provisional; Region: PRK13562 1123523006213 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1123523006214 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1123523006215 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1123523006216 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1123523006217 2-isopropylmalate synthase; Validated; Region: PRK00915 1123523006218 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1123523006219 active site 1123523006220 catalytic residues [active] 1123523006221 metal binding site [ion binding]; metal-binding site 1123523006222 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1123523006223 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1123523006224 tartrate dehydrogenase; Region: TTC; TIGR02089 1123523006225 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1123523006226 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1123523006227 substrate binding site [chemical binding]; other site 1123523006228 ligand binding site [chemical binding]; other site 1123523006229 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1123523006230 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1123523006231 substrate binding site [chemical binding]; other site 1123523006232 threonine dehydratase; Validated; Region: PRK08639 1123523006233 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1123523006234 tetramer interface [polypeptide binding]; other site 1123523006235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523006236 catalytic residue [active] 1123523006237 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1123523006238 putative Ile/Val binding site [chemical binding]; other site 1123523006239 hypothetical protein; Provisional; Region: PRK04351 1123523006240 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1123523006241 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1123523006242 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1123523006243 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1123523006244 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1123523006245 RNA binding site [nucleotide binding]; other site 1123523006246 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1123523006247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1123523006248 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1123523006249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1123523006250 DNA binding residues [nucleotide binding] 1123523006251 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1123523006252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523006253 ATP binding site [chemical binding]; other site 1123523006254 Mg2+ binding site [ion binding]; other site 1123523006255 G-X-G motif; other site 1123523006256 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1123523006257 anti sigma factor interaction site; other site 1123523006258 regulatory phosphorylation site [posttranslational modification]; other site 1123523006259 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1123523006260 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1123523006261 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1123523006262 PemK-like protein; Region: PemK; pfam02452 1123523006263 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1123523006264 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1123523006265 active site 1123523006266 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1123523006267 dimer interface [polypeptide binding]; other site 1123523006268 substrate binding site [chemical binding]; other site 1123523006269 catalytic residues [active] 1123523006270 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1123523006271 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1123523006272 Predicted membrane protein [Function unknown]; Region: COG3428 1123523006273 Bacterial PH domain; Region: DUF304; pfam03703 1123523006274 Bacterial PH domain; Region: DUF304; pfam03703 1123523006275 Bacterial PH domain; Region: DUF304; cl01348 1123523006276 potassium-transporting ATPase subunit C; Provisional; Region: PRK13998 1123523006277 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 1123523006278 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1123523006279 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1123523006280 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060 1123523006281 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1123523006282 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1123523006283 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1123523006284 Ligand Binding Site [chemical binding]; other site 1123523006285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1123523006286 dimer interface [polypeptide binding]; other site 1123523006287 phosphorylation site [posttranslational modification] 1123523006288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523006289 ATP binding site [chemical binding]; other site 1123523006290 Mg2+ binding site [ion binding]; other site 1123523006291 G-X-G motif; other site 1123523006292 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523006293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523006294 active site 1123523006295 phosphorylation site [posttranslational modification] 1123523006296 intermolecular recognition site; other site 1123523006297 dimerization interface [polypeptide binding]; other site 1123523006298 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523006299 DNA binding site [nucleotide binding] 1123523006300 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1123523006301 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1123523006302 ATP binding site [chemical binding]; other site 1123523006303 Mg++ binding site [ion binding]; other site 1123523006304 motif III; other site 1123523006305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1123523006306 nucleotide binding region [chemical binding]; other site 1123523006307 ATP-binding site [chemical binding]; other site 1123523006308 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1123523006309 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1123523006310 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1123523006311 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1123523006312 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1123523006313 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1123523006314 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1123523006315 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1123523006316 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1123523006317 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1123523006318 putative homodimer interface [polypeptide binding]; other site 1123523006319 putative homotetramer interface [polypeptide binding]; other site 1123523006320 allosteric switch controlling residues; other site 1123523006321 putative metal binding site [ion binding]; other site 1123523006322 putative homodimer-homodimer interface [polypeptide binding]; other site 1123523006323 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1123523006324 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1123523006325 putative active site [active] 1123523006326 catalytic site [active] 1123523006327 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1123523006328 putative active site [active] 1123523006329 catalytic site [active] 1123523006330 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1123523006331 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1123523006332 Zn2+ binding site [ion binding]; other site 1123523006333 Mg2+ binding site [ion binding]; other site 1123523006334 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1123523006335 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1123523006336 thiamine phosphate binding site [chemical binding]; other site 1123523006337 active site 1123523006338 pyrophosphate binding site [ion binding]; other site 1123523006339 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1123523006340 substrate binding site [chemical binding]; other site 1123523006341 multimerization interface [polypeptide binding]; other site 1123523006342 ATP binding site [chemical binding]; other site 1123523006343 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1123523006344 dimer interface [polypeptide binding]; other site 1123523006345 substrate binding site [chemical binding]; other site 1123523006346 ATP binding site [chemical binding]; other site 1123523006347 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1123523006348 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1123523006349 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1123523006350 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1123523006351 dimer interface [polypeptide binding]; other site 1123523006352 ssDNA binding site [nucleotide binding]; other site 1123523006353 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1123523006354 YwpF-like protein; Region: YwpF; pfam14183 1123523006355 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1123523006356 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1123523006357 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1123523006358 hinge; other site 1123523006359 active site 1123523006360 Predicted membrane protein [Function unknown]; Region: COG4836 1123523006361 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 1123523006362 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1123523006363 gamma subunit interface [polypeptide binding]; other site 1123523006364 epsilon subunit interface [polypeptide binding]; other site 1123523006365 LBP interface [polypeptide binding]; other site 1123523006366 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1123523006367 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1123523006368 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1123523006369 alpha subunit interaction interface [polypeptide binding]; other site 1123523006370 Walker A motif; other site 1123523006371 ATP binding site [chemical binding]; other site 1123523006372 Walker B motif; other site 1123523006373 inhibitor binding site; inhibition site 1123523006374 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1123523006375 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1123523006376 core domain interface [polypeptide binding]; other site 1123523006377 delta subunit interface [polypeptide binding]; other site 1123523006378 epsilon subunit interface [polypeptide binding]; other site 1123523006379 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1123523006380 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1123523006381 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1123523006382 beta subunit interaction interface [polypeptide binding]; other site 1123523006383 Walker A motif; other site 1123523006384 ATP binding site [chemical binding]; other site 1123523006385 Walker B motif; other site 1123523006386 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1123523006387 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1123523006388 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1123523006389 F0F1 ATP synthase subunit B; Provisional; Region: PRK13453 1123523006390 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1123523006391 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1123523006392 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1123523006393 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1123523006394 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1123523006395 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1123523006396 active site 1123523006397 homodimer interface [polypeptide binding]; other site 1123523006398 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1123523006399 active site 1123523006400 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1123523006401 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1123523006402 dimer interface [polypeptide binding]; other site 1123523006403 active site 1123523006404 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1123523006405 folate binding site [chemical binding]; other site 1123523006406 hypothetical protein; Provisional; Region: PRK13690 1123523006407 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1123523006408 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1123523006409 active site 1123523006410 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1123523006411 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1123523006412 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1123523006413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523006414 S-adenosylmethionine binding site [chemical binding]; other site 1123523006415 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1123523006416 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1123523006417 RF-1 domain; Region: RF-1; pfam00472 1123523006418 thymidine kinase; Provisional; Region: PRK04296 1123523006419 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1123523006420 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1123523006421 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1123523006422 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1123523006423 RNA binding site [nucleotide binding]; other site 1123523006424 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1123523006425 multimer interface [polypeptide binding]; other site 1123523006426 Walker A motif; other site 1123523006427 ATP binding site [chemical binding]; other site 1123523006428 Walker B motif; other site 1123523006429 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1123523006430 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1123523006431 NAD binding site [chemical binding]; other site 1123523006432 catalytic residues [active] 1123523006433 Predicted transcriptional regulators [Transcription]; Region: COG1733 1123523006434 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1123523006435 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1123523006436 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1123523006437 hinge; other site 1123523006438 active site 1123523006439 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1123523006440 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1123523006441 intersubunit interface [polypeptide binding]; other site 1123523006442 active site 1123523006443 zinc binding site [ion binding]; other site 1123523006444 Na+ binding site [ion binding]; other site 1123523006445 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1123523006446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1123523006447 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1123523006448 CTP synthetase; Validated; Region: pyrG; PRK05380 1123523006449 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1123523006450 Catalytic site [active] 1123523006451 active site 1123523006452 UTP binding site [chemical binding]; other site 1123523006453 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1123523006454 active site 1123523006455 putative oxyanion hole; other site 1123523006456 catalytic triad [active] 1123523006457 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1123523006458 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1123523006459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523006460 Coenzyme A binding pocket [chemical binding]; other site 1123523006461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1123523006462 Coenzyme A binding pocket [chemical binding]; other site 1123523006463 pantothenate kinase; Provisional; Region: PRK13317 1123523006464 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 1123523006465 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1123523006466 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1123523006467 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1123523006468 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1123523006469 metal binding site [ion binding]; metal-binding site 1123523006470 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1123523006471 Predicted membrane protein [Function unknown]; Region: COG4270 1123523006472 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1123523006473 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1123523006474 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1123523006475 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1123523006476 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1123523006477 intersubunit interface [polypeptide binding]; other site 1123523006478 active site 1123523006479 catalytic residue [active] 1123523006480 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1123523006481 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1123523006482 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1123523006483 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1123523006484 dimerization interface [polypeptide binding]; other site 1123523006485 DPS ferroxidase diiron center [ion binding]; other site 1123523006486 ion pore; other site 1123523006487 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1123523006488 EVE domain; Region: EVE; cl00728 1123523006489 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1123523006490 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1123523006491 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1123523006492 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1123523006493 NAD(P) binding site [chemical binding]; other site 1123523006494 putative active site [active] 1123523006495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1123523006496 dimerization interface [polypeptide binding]; other site 1123523006497 putative DNA binding site [nucleotide binding]; other site 1123523006498 putative Zn2+ binding site [ion binding]; other site 1123523006499 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1123523006500 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1123523006501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1123523006502 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1123523006503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523006504 active site 1123523006505 motif I; other site 1123523006506 motif II; other site 1123523006507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523006508 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1123523006509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523006510 Walker A/P-loop; other site 1123523006511 ATP binding site [chemical binding]; other site 1123523006512 Q-loop/lid; other site 1123523006513 ABC transporter signature motif; other site 1123523006514 Walker B; other site 1123523006515 D-loop; other site 1123523006516 H-loop/switch region; other site 1123523006517 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1123523006518 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1123523006519 glutaminase active site [active] 1123523006520 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1123523006521 dimer interface [polypeptide binding]; other site 1123523006522 active site 1123523006523 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1123523006524 dimer interface [polypeptide binding]; other site 1123523006525 active site 1123523006526 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1123523006527 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1123523006528 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1123523006529 active site 1123523006530 P-loop; other site 1123523006531 phosphorylation site [posttranslational modification] 1123523006532 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1123523006533 HTH domain; Region: HTH_11; pfam08279 1123523006534 Mga helix-turn-helix domain; Region: Mga; pfam05043 1123523006535 PRD domain; Region: PRD; pfam00874 1123523006536 PRD domain; Region: PRD; pfam00874 1123523006537 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1123523006538 active site 1123523006539 P-loop; other site 1123523006540 phosphorylation site [posttranslational modification] 1123523006541 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1123523006542 active site 1123523006543 phosphorylation site [posttranslational modification] 1123523006544 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1123523006545 active site 1123523006546 phosphorylation site [posttranslational modification] 1123523006547 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1123523006548 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1123523006549 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1123523006550 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523006551 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 1123523006552 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523006553 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523006554 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523006555 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523006556 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523006557 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523006558 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523006559 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 1123523006560 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1123523006561 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1123523006562 active site 1123523006563 substrate binding site [chemical binding]; other site 1123523006564 metal binding site [ion binding]; metal-binding site 1123523006565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1123523006566 YbbR-like protein; Region: YbbR; pfam07949 1123523006567 TIGR00159 family protein; Region: TIGR00159 1123523006568 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1123523006569 Arginase family; Region: Arginase; cd09989 1123523006570 active site 1123523006571 Mn binding site [ion binding]; other site 1123523006572 oligomer interface [polypeptide binding]; other site 1123523006573 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1123523006574 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1123523006575 Walker A motif; other site 1123523006576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523006577 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523006578 putative substrate translocation pore; other site 1123523006579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523006580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523006581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523006582 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1123523006583 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1123523006584 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1123523006585 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1123523006586 substrate binding site; other site 1123523006587 dimerization interface; other site 1123523006588 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1123523006589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1123523006590 Nucleoside recognition; Region: Gate; pfam07670 1123523006591 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1123523006592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523006593 ABC-ATPase subunit interface; other site 1123523006594 dimer interface [polypeptide binding]; other site 1123523006595 putative PBP binding regions; other site 1123523006596 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1123523006597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1123523006598 ABC-ATPase subunit interface; other site 1123523006599 dimer interface [polypeptide binding]; other site 1123523006600 putative PBP binding regions; other site 1123523006601 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1123523006602 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1123523006603 siderophore binding site; other site 1123523006604 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1123523006605 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1123523006606 dimer interface [polypeptide binding]; other site 1123523006607 active site 1123523006608 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1123523006609 substrate binding site [chemical binding]; other site 1123523006610 catalytic residue [active] 1123523006611 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1123523006612 IucA / IucC family; Region: IucA_IucC; pfam04183 1123523006613 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1123523006614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523006615 putative substrate translocation pore; other site 1123523006616 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1123523006617 IucA / IucC family; Region: IucA_IucC; pfam04183 1123523006618 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1123523006619 Asp23 family; Region: Asp23; pfam03780 1123523006620 Small integral membrane protein [Function unknown]; Region: COG5547 1123523006621 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1123523006622 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1123523006623 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1123523006624 putative NAD(P) binding site [chemical binding]; other site 1123523006625 dimer interface [polypeptide binding]; other site 1123523006626 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1123523006627 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1123523006628 NAD(P) binding site [chemical binding]; other site 1123523006629 substrate binding site [chemical binding]; other site 1123523006630 dimer interface [polypeptide binding]; other site 1123523006631 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1123523006632 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1123523006633 beta-galactosidase; Region: BGL; TIGR03356 1123523006634 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 1123523006635 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1123523006636 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1123523006637 active site 1123523006638 P-loop; other site 1123523006639 phosphorylation site [posttranslational modification] 1123523006640 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1123523006641 methionine cluster; other site 1123523006642 active site 1123523006643 phosphorylation site [posttranslational modification] 1123523006644 metal binding site [ion binding]; metal-binding site 1123523006645 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1123523006646 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1123523006647 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1123523006648 putative substrate binding site [chemical binding]; other site 1123523006649 putative ATP binding site [chemical binding]; other site 1123523006650 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1123523006651 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1123523006652 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1123523006653 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1123523006654 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1123523006655 NAD-dependent deacetylase; Provisional; Region: PRK00481 1123523006656 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1123523006657 NAD+ binding site [chemical binding]; other site 1123523006658 substrate binding site [chemical binding]; other site 1123523006659 putative Zn binding site [ion binding]; other site 1123523006660 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1123523006661 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1123523006662 active site 1123523006663 catalytic tetrad [active] 1123523006664 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1123523006665 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1123523006666 DNA binding residues [nucleotide binding] 1123523006667 putative dimer interface [polypeptide binding]; other site 1123523006668 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1123523006669 substrate binding site [chemical binding]; other site 1123523006670 catalytic residues [active] 1123523006671 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1123523006672 Peptidase family M23; Region: Peptidase_M23; pfam01551 1123523006673 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1123523006674 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1123523006675 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1123523006676 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1123523006677 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1123523006678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523006679 S-adenosylmethionine binding site [chemical binding]; other site 1123523006680 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1123523006681 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1123523006682 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1123523006683 active site 1123523006684 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 1123523006685 active site 1123523006686 conformational flexibility of ligand binding pocket; other site 1123523006687 ADP-ribosylating toxin turn-turn motif; other site 1123523006688 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1123523006689 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1123523006690 putative active site [active] 1123523006691 putative NTP binding site [chemical binding]; other site 1123523006692 putative nucleic acid binding site [nucleotide binding]; other site 1123523006693 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1123523006694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1123523006695 active site 1123523006696 motif I; other site 1123523006697 motif II; other site 1123523006698 MAP domain; Region: MAP; pfam03642 1123523006699 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1123523006700 acetolactate synthase; Reviewed; Region: PRK08617 1123523006701 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1123523006702 PYR/PP interface [polypeptide binding]; other site 1123523006703 dimer interface [polypeptide binding]; other site 1123523006704 TPP binding site [chemical binding]; other site 1123523006705 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1123523006706 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1123523006707 TPP-binding site [chemical binding]; other site 1123523006708 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1123523006709 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1123523006710 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1123523006711 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1123523006712 23S rRNA interface [nucleotide binding]; other site 1123523006713 L3 interface [polypeptide binding]; other site 1123523006714 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1123523006715 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1123523006716 dimerization interface 3.5A [polypeptide binding]; other site 1123523006717 active site 1123523006718 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1123523006719 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13646 1123523006720 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1123523006721 Walker A/P-loop; other site 1123523006722 ATP binding site [chemical binding]; other site 1123523006723 Q-loop/lid; other site 1123523006724 ABC transporter signature motif; other site 1123523006725 Walker B; other site 1123523006726 D-loop; other site 1123523006727 H-loop/switch region; other site 1123523006728 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 1123523006729 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1123523006730 Walker A/P-loop; other site 1123523006731 ATP binding site [chemical binding]; other site 1123523006732 Q-loop/lid; other site 1123523006733 ABC transporter signature motif; other site 1123523006734 Walker B; other site 1123523006735 D-loop; other site 1123523006736 H-loop/switch region; other site 1123523006737 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1123523006738 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1123523006739 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1123523006740 alphaNTD homodimer interface [polypeptide binding]; other site 1123523006741 alphaNTD - beta interaction site [polypeptide binding]; other site 1123523006742 alphaNTD - beta' interaction site [polypeptide binding]; other site 1123523006743 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1123523006744 30S ribosomal protein S11; Validated; Region: PRK05309 1123523006745 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1123523006746 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1123523006747 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1123523006748 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1123523006749 rRNA binding site [nucleotide binding]; other site 1123523006750 predicted 30S ribosome binding site; other site 1123523006751 adenylate kinase; Reviewed; Region: adk; PRK00279 1123523006752 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1123523006753 AMP-binding site [chemical binding]; other site 1123523006754 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1123523006755 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1123523006756 SecY translocase; Region: SecY; pfam00344 1123523006757 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1123523006758 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1123523006759 23S rRNA binding site [nucleotide binding]; other site 1123523006760 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1123523006761 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1123523006762 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1123523006763 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1123523006764 5S rRNA interface [nucleotide binding]; other site 1123523006765 L27 interface [polypeptide binding]; other site 1123523006766 23S rRNA interface [nucleotide binding]; other site 1123523006767 L5 interface [polypeptide binding]; other site 1123523006768 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1123523006769 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1123523006770 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1123523006771 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1123523006772 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1123523006773 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1123523006774 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1123523006775 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1123523006776 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1123523006777 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1123523006778 RNA binding site [nucleotide binding]; other site 1123523006779 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1123523006780 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1123523006781 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1123523006782 23S rRNA interface [nucleotide binding]; other site 1123523006783 putative translocon interaction site; other site 1123523006784 signal recognition particle (SRP54) interaction site; other site 1123523006785 L23 interface [polypeptide binding]; other site 1123523006786 trigger factor interaction site; other site 1123523006787 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1123523006788 23S rRNA interface [nucleotide binding]; other site 1123523006789 5S rRNA interface [nucleotide binding]; other site 1123523006790 putative antibiotic binding site [chemical binding]; other site 1123523006791 L25 interface [polypeptide binding]; other site 1123523006792 L27 interface [polypeptide binding]; other site 1123523006793 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1123523006794 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1123523006795 G-X-X-G motif; other site 1123523006796 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1123523006797 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1123523006798 putative translocon binding site; other site 1123523006799 protein-rRNA interface [nucleotide binding]; other site 1123523006800 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1123523006801 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1123523006802 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1123523006803 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1123523006804 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1123523006805 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1123523006806 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1123523006807 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1123523006808 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1123523006809 DNA topoisomerase III; Provisional; Region: PRK07726 1123523006810 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1123523006811 active site 1123523006812 putative interdomain interaction site [polypeptide binding]; other site 1123523006813 putative metal-binding site [ion binding]; other site 1123523006814 putative nucleotide binding site [chemical binding]; other site 1123523006815 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1123523006816 domain I; other site 1123523006817 DNA binding groove [nucleotide binding] 1123523006818 phosphate binding site [ion binding]; other site 1123523006819 domain II; other site 1123523006820 domain III; other site 1123523006821 nucleotide binding site [chemical binding]; other site 1123523006822 catalytic site [active] 1123523006823 domain IV; other site 1123523006824 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1123523006825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523006826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1123523006827 Coenzyme A binding pocket [chemical binding]; other site 1123523006828 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1123523006829 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1123523006830 Predicted permeases [General function prediction only]; Region: COG0679 1123523006831 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1123523006832 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1123523006833 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1123523006834 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1123523006835 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1123523006836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523006837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523006838 putative substrate translocation pore; other site 1123523006839 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523006840 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1123523006841 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1123523006842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523006843 FeS/SAM binding site; other site 1123523006844 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1123523006845 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1123523006846 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1123523006847 GTP binding site; other site 1123523006848 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1123523006849 MoaE interaction surface [polypeptide binding]; other site 1123523006850 MoeB interaction surface [polypeptide binding]; other site 1123523006851 thiocarboxylated glycine; other site 1123523006852 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1123523006853 MoaE homodimer interface [polypeptide binding]; other site 1123523006854 MoaD interaction [polypeptide binding]; other site 1123523006855 active site residues [active] 1123523006856 Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism]; Region: MobB; COG1763 1123523006857 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1123523006858 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1123523006859 dimer interface [polypeptide binding]; other site 1123523006860 putative functional site; other site 1123523006861 putative MPT binding site; other site 1123523006862 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1123523006863 trimer interface [polypeptide binding]; other site 1123523006864 dimer interface [polypeptide binding]; other site 1123523006865 putative active site [active] 1123523006866 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1123523006867 MPT binding site; other site 1123523006868 trimer interface [polypeptide binding]; other site 1123523006869 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1123523006870 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1123523006871 ATP binding site [chemical binding]; other site 1123523006872 substrate interface [chemical binding]; other site 1123523006873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523006874 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1123523006875 Walker A/P-loop; other site 1123523006876 ATP binding site [chemical binding]; other site 1123523006877 Q-loop/lid; other site 1123523006878 ABC transporter signature motif; other site 1123523006879 Walker B; other site 1123523006880 D-loop; other site 1123523006881 H-loop/switch region; other site 1123523006882 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1123523006883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523006884 dimer interface [polypeptide binding]; other site 1123523006885 conserved gate region; other site 1123523006886 putative PBP binding loops; other site 1123523006887 ABC-ATPase subunit interface; other site 1123523006888 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1123523006889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1123523006890 substrate binding pocket [chemical binding]; other site 1123523006891 membrane-bound complex binding site; other site 1123523006892 hinge residues; other site 1123523006893 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1123523006894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523006895 Coenzyme A binding pocket [chemical binding]; other site 1123523006896 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1123523006897 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1123523006898 active site 1123523006899 dimerization interface [polypeptide binding]; other site 1123523006900 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1123523006901 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1123523006902 intersubunit interface [polypeptide binding]; other site 1123523006903 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1123523006904 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1123523006905 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1123523006906 Urea transporter [Amino acid transport and metabolism]; Region: Utp; COG4413 1123523006907 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1123523006908 alpha-gamma subunit interface [polypeptide binding]; other site 1123523006909 beta-gamma subunit interface [polypeptide binding]; other site 1123523006910 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1123523006911 gamma-beta subunit interface [polypeptide binding]; other site 1123523006912 alpha-beta subunit interface [polypeptide binding]; other site 1123523006913 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1123523006914 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1123523006915 subunit interactions [polypeptide binding]; other site 1123523006916 active site 1123523006917 flap region; other site 1123523006918 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1123523006919 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1123523006920 dimer interface [polypeptide binding]; other site 1123523006921 catalytic residues [active] 1123523006922 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1123523006923 UreF; Region: UreF; pfam01730 1123523006924 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1123523006925 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1123523006926 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523006927 MarR family; Region: MarR_2; cl17246 1123523006928 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523006929 Helix-turn-helix domain; Region: HTH_18; pfam12833 1123523006930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1123523006931 Surface antigen [General function prediction only]; Region: COG3942 1123523006932 CHAP domain; Region: CHAP; pfam05257 1123523006933 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1123523006934 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1123523006935 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1123523006936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 1123523006937 Surface antigen [General function prediction only]; Region: COG3942 1123523006938 CHAP domain; Region: CHAP; pfam05257 1123523006939 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1123523006940 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1123523006941 putative ligand binding site [chemical binding]; other site 1123523006942 putative NAD binding site [chemical binding]; other site 1123523006943 catalytic site [active] 1123523006944 hypothetical protein; Provisional; Region: PRK06753 1123523006945 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1123523006946 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1123523006947 Lysozyme subfamily 2; Region: LYZ2; smart00047 1123523006948 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1123523006949 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1123523006950 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1123523006951 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1123523006952 4Fe-4S binding domain; Region: Fer4; pfam00037 1123523006953 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1123523006954 [4Fe-4S] binding site [ion binding]; other site 1123523006955 molybdopterin cofactor binding site; other site 1123523006956 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1123523006957 molybdopterin cofactor binding site; other site 1123523006958 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1123523006959 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1123523006960 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1123523006961 active site 1123523006962 Predicted transcriptional regulator [Transcription]; Region: COG2378 1123523006963 HTH domain; Region: HTH_11; pfam08279 1123523006964 CAAX protease self-immunity; Region: Abi; pfam02517 1123523006965 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1123523006966 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1123523006967 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1123523006968 putative active site [active] 1123523006969 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1123523006970 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1123523006971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523006972 active site 1123523006973 motif I; other site 1123523006974 motif II; other site 1123523006975 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1123523006976 Sodium Bile acid symporter family; Region: SBF; pfam01758 1123523006977 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1123523006978 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1123523006979 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1123523006980 active site turn [active] 1123523006981 phosphorylation site [posttranslational modification] 1123523006982 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1123523006983 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1123523006984 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1123523006985 putative active site [active] 1123523006986 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1123523006987 putative hydrophobic ligand binding site [chemical binding]; other site 1123523006988 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1123523006989 oxidoreductase; Provisional; Region: PRK06128 1123523006990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1123523006991 NAD(P) binding site [chemical binding]; other site 1123523006992 active site 1123523006993 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1123523006994 amidohydrolase; Region: amidohydrolases; TIGR01891 1123523006995 metal binding site [ion binding]; metal-binding site 1123523006996 dimer interface [polypeptide binding]; other site 1123523006997 imidazolonepropionase; Validated; Region: PRK09356 1123523006998 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1123523006999 active site 1123523007000 urocanate hydratase; Provisional; Region: PRK05414 1123523007001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1123523007002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1123523007003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1123523007004 dimerization interface [polypeptide binding]; other site 1123523007005 formimidoylglutamase; Provisional; Region: PRK13775 1123523007006 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1123523007007 putative active site [active] 1123523007008 putative metal binding site [ion binding]; other site 1123523007009 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1123523007010 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1123523007011 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1123523007012 active site 1123523007013 dimer interface [polypeptide binding]; other site 1123523007014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1123523007015 MOSC domain; Region: MOSC; pfam03473 1123523007016 3-alpha domain; Region: 3-alpha; pfam03475 1123523007017 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1123523007018 active site 1123523007019 catalytic residues [active] 1123523007020 Uncharacterized conserved protein [Function unknown]; Region: COG1742 1123523007021 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1123523007022 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1123523007023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523007024 Walker A/P-loop; other site 1123523007025 ATP binding site [chemical binding]; other site 1123523007026 Q-loop/lid; other site 1123523007027 ABC transporter signature motif; other site 1123523007028 Walker B; other site 1123523007029 D-loop; other site 1123523007030 H-loop/switch region; other site 1123523007031 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1123523007032 Predicted membrane protein [Function unknown]; Region: COG3152 1123523007033 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1123523007034 active site 1123523007035 DNA binding site [nucleotide binding] 1123523007036 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1123523007037 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1123523007038 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1123523007039 homotetramer interface [polypeptide binding]; other site 1123523007040 FMN binding site [chemical binding]; other site 1123523007041 homodimer contacts [polypeptide binding]; other site 1123523007042 putative active site [active] 1123523007043 putative substrate binding site [chemical binding]; other site 1123523007044 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1123523007045 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1123523007046 oligomer interface [polypeptide binding]; other site 1123523007047 metal binding site [ion binding]; metal-binding site 1123523007048 metal binding site [ion binding]; metal-binding site 1123523007049 putative Cl binding site [ion binding]; other site 1123523007050 aspartate ring; other site 1123523007051 basic sphincter; other site 1123523007052 hydrophobic gate; other site 1123523007053 periplasmic entrance; other site 1123523007054 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1123523007055 active site 1123523007056 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1123523007057 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1123523007058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007059 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1123523007060 putative substrate translocation pore; other site 1123523007061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007062 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1123523007063 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1123523007064 HlyD family secretion protein; Region: HlyD_3; pfam13437 1123523007065 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1123523007066 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1123523007067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007068 putative substrate translocation pore; other site 1123523007069 Predicted membrane protein [Function unknown]; Region: COG4640 1123523007070 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1123523007071 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1123523007072 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1123523007073 putative Zn2+ binding site [ion binding]; other site 1123523007074 putative DNA binding site [nucleotide binding]; other site 1123523007075 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1123523007076 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1123523007077 putative active site [active] 1123523007078 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1123523007079 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1123523007080 Walker A/P-loop; other site 1123523007081 ATP binding site [chemical binding]; other site 1123523007082 Q-loop/lid; other site 1123523007083 ABC transporter signature motif; other site 1123523007084 Walker B; other site 1123523007085 D-loop; other site 1123523007086 H-loop/switch region; other site 1123523007087 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1123523007088 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1123523007089 FtsX-like permease family; Region: FtsX; pfam02687 1123523007090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523007091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523007092 active site 1123523007093 phosphorylation site [posttranslational modification] 1123523007094 intermolecular recognition site; other site 1123523007095 dimerization interface [polypeptide binding]; other site 1123523007096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523007097 DNA binding site [nucleotide binding] 1123523007098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1123523007099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1123523007100 dimerization interface [polypeptide binding]; other site 1123523007101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1123523007102 dimer interface [polypeptide binding]; other site 1123523007103 phosphorylation site [posttranslational modification] 1123523007104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523007105 ATP binding site [chemical binding]; other site 1123523007106 Mg2+ binding site [ion binding]; other site 1123523007107 G-X-G motif; other site 1123523007108 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1123523007109 LytTr DNA-binding domain; Region: LytTR; smart00850 1123523007110 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1123523007111 Malate:quinone oxidoreductase (Mqo); Region: Mqo; pfam06039 1123523007112 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1123523007113 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1123523007114 L-lactate permease; Region: Lactate_perm; cl00701 1123523007115 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1123523007116 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1123523007117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523007118 Coenzyme A binding pocket [chemical binding]; other site 1123523007119 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1123523007120 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1123523007121 NAD(P) binding site [chemical binding]; other site 1123523007122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523007123 Coenzyme A binding pocket [chemical binding]; other site 1123523007124 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1123523007125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1123523007126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523007127 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 1123523007128 Predicted membrane protein [Function unknown]; Region: COG1511 1123523007129 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1123523007130 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1123523007131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1123523007132 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1123523007133 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1123523007134 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1123523007135 Cl binding site [ion binding]; other site 1123523007136 oligomer interface [polypeptide binding]; other site 1123523007137 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1123523007138 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1123523007139 active site turn [active] 1123523007140 phosphorylation site [posttranslational modification] 1123523007141 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1123523007142 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1123523007143 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1123523007144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1123523007145 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1123523007146 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1123523007147 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1123523007148 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1123523007149 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1123523007150 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1123523007151 MarR family; Region: MarR_2; pfam12802 1123523007152 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1123523007153 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1123523007154 putative dimer interface [polypeptide binding]; other site 1123523007155 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1123523007156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007157 putative substrate translocation pore; other site 1123523007158 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1123523007159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523007160 active site 1123523007161 phosphorylation site [posttranslational modification] 1123523007162 intermolecular recognition site; other site 1123523007163 dimerization interface [polypeptide binding]; other site 1123523007164 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1123523007165 DNA binding residues [nucleotide binding] 1123523007166 dimerization interface [polypeptide binding]; other site 1123523007167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1123523007168 Histidine kinase; Region: HisKA_3; pfam07730 1123523007169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523007170 ATP binding site [chemical binding]; other site 1123523007171 Mg2+ binding site [ion binding]; other site 1123523007172 G-X-G motif; other site 1123523007173 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1123523007174 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1123523007175 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1123523007176 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1123523007177 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1123523007178 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1123523007179 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1123523007180 [4Fe-4S] binding site [ion binding]; other site 1123523007181 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1123523007182 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1123523007183 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1123523007184 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1123523007185 molybdopterin cofactor binding site; other site 1123523007186 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1123523007187 active site 1123523007188 SAM binding site [chemical binding]; other site 1123523007189 homodimer interface [polypeptide binding]; other site 1123523007190 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1123523007191 [2Fe-2S] cluster binding site [ion binding]; other site 1123523007192 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1123523007193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1123523007194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1123523007195 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1123523007196 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1123523007197 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1123523007198 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1123523007199 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1123523007200 putative active site [active] 1123523007201 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1123523007202 active site 1123523007203 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1123523007204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523007205 Coenzyme A binding pocket [chemical binding]; other site 1123523007206 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1123523007207 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1123523007208 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1123523007209 putative hydrophobic ligand binding site [chemical binding]; other site 1123523007210 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1123523007211 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1123523007212 intersubunit interface [polypeptide binding]; other site 1123523007213 YodA lipocalin-like domain; Region: YodA; pfam09223 1123523007214 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1123523007215 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1123523007216 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1123523007217 Thioredoxin; Region: Thioredoxin_4; cl17273 1123523007218 FemAB family; Region: FemAB; pfam02388 1123523007219 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1123523007220 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1123523007221 Walker A/P-loop; other site 1123523007222 ATP binding site [chemical binding]; other site 1123523007223 Q-loop/lid; other site 1123523007224 ABC transporter signature motif; other site 1123523007225 Walker B; other site 1123523007226 D-loop; other site 1123523007227 H-loop/switch region; other site 1123523007228 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1123523007229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523007230 dimer interface [polypeptide binding]; other site 1123523007231 conserved gate region; other site 1123523007232 putative PBP binding loops; other site 1123523007233 ABC-ATPase subunit interface; other site 1123523007234 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1123523007235 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1123523007236 substrate binding pocket [chemical binding]; other site 1123523007237 membrane-bound complex binding site; other site 1123523007238 hinge residues; other site 1123523007239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523007241 putative substrate translocation pore; other site 1123523007242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007243 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1123523007244 catalytic core [active] 1123523007245 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1123523007246 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1123523007247 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1123523007248 B domain; Region: B; pfam02216 1123523007249 B domain; Region: B; pfam02216 1123523007250 C3 binding domain 4 of IgG-bind protein SBI; Region: Sbi-IV; pfam11621 1123523007251 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1123523007252 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 1123523007253 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 1123523007254 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1123523007255 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1123523007256 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1123523007257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1123523007258 catalytic residue [active] 1123523007259 biotin synthase; Validated; Region: PRK06256 1123523007260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523007261 FeS/SAM binding site; other site 1123523007262 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1123523007263 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1123523007264 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1123523007265 inhibitor-cofactor binding pocket; inhibition site 1123523007266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523007267 catalytic residue [active] 1123523007268 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1123523007269 AAA domain; Region: AAA_26; pfam13500 1123523007270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523007271 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1123523007272 Walker A/P-loop; other site 1123523007273 ATP binding site [chemical binding]; other site 1123523007274 Q-loop/lid; other site 1123523007275 ABC transporter signature motif; other site 1123523007276 Walker B; other site 1123523007277 D-loop; other site 1123523007278 H-loop/switch region; other site 1123523007279 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1123523007280 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1123523007281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523007282 Walker A/P-loop; other site 1123523007283 ATP binding site [chemical binding]; other site 1123523007284 Q-loop/lid; other site 1123523007285 ABC transporter signature motif; other site 1123523007286 Walker B; other site 1123523007287 D-loop; other site 1123523007288 H-loop/switch region; other site 1123523007289 Predicted membrane protein [Function unknown]; Region: COG2246 1123523007290 GtrA-like protein; Region: GtrA; pfam04138 1123523007291 glycerate kinase; Region: TIGR00045 1123523007292 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1123523007293 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1123523007294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007295 putative substrate translocation pore; other site 1123523007296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1123523007297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4990 1123523007298 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1123523007299 putative phosphoesterase; Region: acc_ester; TIGR03729 1123523007300 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1123523007301 Spore germination protein; Region: Spore_permease; cl17796 1123523007302 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1123523007303 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1123523007304 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1123523007305 Beta-lactamase; Region: Beta-lactamase; pfam00144 1123523007306 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1123523007307 extended (e) SDRs; Region: SDR_e; cd08946 1123523007308 NAD(P) binding site [chemical binding]; other site 1123523007309 active site 1123523007310 substrate binding site [chemical binding]; other site 1123523007311 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1123523007312 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1123523007313 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1123523007314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007315 putative substrate translocation pore; other site 1123523007316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523007318 dimer interface [polypeptide binding]; other site 1123523007319 conserved gate region; other site 1123523007320 ABC-ATPase subunit interface; other site 1123523007321 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1123523007322 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1123523007323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523007324 dimer interface [polypeptide binding]; other site 1123523007325 conserved gate region; other site 1123523007326 putative PBP binding loops; other site 1123523007327 ABC-ATPase subunit interface; other site 1123523007328 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1123523007329 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1123523007330 Walker A/P-loop; other site 1123523007331 ATP binding site [chemical binding]; other site 1123523007332 Q-loop/lid; other site 1123523007333 ABC transporter signature motif; other site 1123523007334 Walker B; other site 1123523007335 D-loop; other site 1123523007336 H-loop/switch region; other site 1123523007337 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1123523007338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1123523007339 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1123523007340 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1123523007341 amino acid transporter; Region: 2A0306; TIGR00909 1123523007342 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1123523007343 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1123523007344 substrate binding pocket [chemical binding]; other site 1123523007345 catalytic triad [active] 1123523007346 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1123523007347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007348 putative substrate translocation pore; other site 1123523007349 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1123523007350 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1123523007351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523007352 Walker A/P-loop; other site 1123523007353 ATP binding site [chemical binding]; other site 1123523007354 Q-loop/lid; other site 1123523007355 ABC transporter signature motif; other site 1123523007356 Walker B; other site 1123523007357 D-loop; other site 1123523007358 H-loop/switch region; other site 1123523007359 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1123523007360 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1123523007361 oligomer interface [polypeptide binding]; other site 1123523007362 active site 1123523007363 metal binding site [ion binding]; metal-binding site 1123523007364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4115 1123523007365 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1123523007366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1123523007367 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1123523007368 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1123523007369 active site 1123523007370 FMN binding site [chemical binding]; other site 1123523007371 substrate binding site [chemical binding]; other site 1123523007372 3Fe-4S cluster binding site [ion binding]; other site 1123523007373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523007375 putative substrate translocation pore; other site 1123523007376 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1123523007377 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523007378 Walker A/P-loop; other site 1123523007379 ATP binding site [chemical binding]; other site 1123523007380 Q-loop/lid; other site 1123523007381 ABC transporter signature motif; other site 1123523007382 Walker B; other site 1123523007383 D-loop; other site 1123523007384 H-loop/switch region; other site 1123523007385 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1123523007386 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1123523007387 Walker A/P-loop; other site 1123523007388 ATP binding site [chemical binding]; other site 1123523007389 Q-loop/lid; other site 1123523007390 ABC transporter signature motif; other site 1123523007391 Walker B; other site 1123523007392 D-loop; other site 1123523007393 H-loop/switch region; other site 1123523007394 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1123523007395 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1123523007396 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1123523007397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523007398 dimer interface [polypeptide binding]; other site 1123523007399 conserved gate region; other site 1123523007400 putative PBP binding loops; other site 1123523007401 ABC-ATPase subunit interface; other site 1123523007402 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1123523007403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1123523007404 dimer interface [polypeptide binding]; other site 1123523007405 conserved gate region; other site 1123523007406 putative PBP binding loops; other site 1123523007407 ABC-ATPase subunit interface; other site 1123523007408 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1123523007409 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1123523007410 substrate binding site [chemical binding]; other site 1123523007411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1123523007412 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1123523007413 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1123523007414 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1123523007415 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1123523007416 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1123523007417 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1123523007418 classical (c) SDRs; Region: SDR_c; cd05233 1123523007419 NAD(P) binding site [chemical binding]; other site 1123523007420 active site 1123523007421 AbgT putative transporter family; Region: ABG_transport; pfam03806 1123523007422 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1123523007423 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1123523007424 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1123523007425 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1123523007426 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1123523007427 classical (c) SDRs; Region: SDR_c; cd05233 1123523007428 NAD(P) binding site [chemical binding]; other site 1123523007429 active site 1123523007430 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 1123523007431 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523007432 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523007433 Protein of unknown function, DUF576; Region: DUF576; pfam04507 1123523007434 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1123523007435 PLD-like domain; Region: PLDc_2; pfam13091 1123523007436 putative homodimer interface [polypeptide binding]; other site 1123523007437 putative active site [active] 1123523007438 catalytic site [active] 1123523007439 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1123523007440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1123523007441 ATP binding site [chemical binding]; other site 1123523007442 putative Mg++ binding site [ion binding]; other site 1123523007443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1123523007444 nucleotide binding region [chemical binding]; other site 1123523007445 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1123523007446 ATP-binding site [chemical binding]; other site 1123523007447 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1123523007448 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1123523007449 active site 1123523007450 8-oxo-dGMP binding site [chemical binding]; other site 1123523007451 nudix motif; other site 1123523007452 metal binding site [ion binding]; metal-binding site 1123523007453 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1123523007454 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1123523007455 active site 1123523007456 substrate binding site [chemical binding]; other site 1123523007457 metal binding site [ion binding]; metal-binding site 1123523007458 H+ Antiporter protein; Region: 2A0121; TIGR00900 1123523007459 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523007460 G5 domain; Region: G5; pfam07501 1123523007461 G5 domain; Region: G5; pfam07501 1123523007462 G5 domain; Region: G5; pfam07501 1123523007463 G5 domain; Region: G5; pfam07501 1123523007464 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1123523007465 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523007466 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1123523007467 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523007468 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1123523007469 staphylococcal accessory regulator family; Region: Staph_reg_Sar; TIGR01889 1123523007470 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1123523007471 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1123523007472 active site 1123523007473 tetramer interface; other site 1123523007474 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1123523007475 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1123523007476 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1123523007477 Fibronectin binding repeat; Region: Fn_bind; pfam02986 1123523007478 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1123523007479 GntP family permease; Region: GntP_permease; pfam02447 1123523007480 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1123523007481 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1123523007482 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1123523007483 N- and C-terminal domain interface [polypeptide binding]; other site 1123523007484 active site 1123523007485 catalytic site [active] 1123523007486 metal binding site [ion binding]; metal-binding site 1123523007487 carbohydrate binding site [chemical binding]; other site 1123523007488 ATP binding site [chemical binding]; other site 1123523007489 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1123523007490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1123523007491 DNA-binding site [nucleotide binding]; DNA binding site 1123523007492 FCD domain; Region: FCD; pfam07729 1123523007493 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1123523007494 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1123523007495 DNA binding residues [nucleotide binding] 1123523007496 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1123523007497 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1123523007498 synthetase active site [active] 1123523007499 NTP binding site [chemical binding]; other site 1123523007500 metal binding site [ion binding]; metal-binding site 1123523007501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1123523007502 Predicted membrane protein [Function unknown]; Region: COG1289 1123523007503 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1123523007504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007505 D-galactonate transporter; Region: 2A0114; TIGR00893 1123523007506 putative substrate translocation pore; other site 1123523007507 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1123523007508 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1123523007509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1123523007510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1123523007511 putative substrate translocation pore; other site 1123523007512 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1123523007513 MarR family; Region: MarR; pfam01047 1123523007514 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1123523007515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523007516 Walker A/P-loop; other site 1123523007517 ATP binding site [chemical binding]; other site 1123523007518 Q-loop/lid; other site 1123523007519 ABC transporter signature motif; other site 1123523007520 Walker B; other site 1123523007521 D-loop; other site 1123523007522 H-loop/switch region; other site 1123523007523 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1123523007524 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 1123523007525 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1123523007526 Predicted esterase [General function prediction only]; Region: COG0400 1123523007527 putative hydrolase; Provisional; Region: PRK11460 1123523007528 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1123523007529 MarR family; Region: MarR; pfam01047 1123523007530 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1123523007531 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1123523007532 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1123523007533 putative metal binding site [ion binding]; other site 1123523007534 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1123523007535 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1123523007536 dimer interface [polypeptide binding]; other site 1123523007537 FMN binding site [chemical binding]; other site 1123523007538 D-lactate dehydrogenase; Provisional; Region: PRK12480 1123523007539 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1123523007540 homodimer interface [polypeptide binding]; other site 1123523007541 ligand binding site [chemical binding]; other site 1123523007542 NAD binding site [chemical binding]; other site 1123523007543 catalytic site [active] 1123523007544 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1123523007545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1123523007546 active site 1123523007547 motif I; other site 1123523007548 motif II; other site 1123523007549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1123523007550 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1123523007551 Walker A/P-loop; other site 1123523007552 ATP binding site [chemical binding]; other site 1123523007553 Q-loop/lid; other site 1123523007554 ABC transporter signature motif; other site 1123523007555 Walker B; other site 1123523007556 D-loop; other site 1123523007557 H-loop/switch region; other site 1123523007558 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 1123523007559 active site 1123523007560 catalytic site [active] 1123523007561 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1123523007562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523007563 Coenzyme A binding pocket [chemical binding]; other site 1123523007564 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1123523007565 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1123523007566 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1123523007567 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1123523007568 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1123523007569 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1123523007570 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1123523007571 EamA-like transporter family; Region: EamA; pfam00892 1123523007572 EamA-like transporter family; Region: EamA; pfam00892 1123523007573 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1123523007574 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1123523007575 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1123523007576 catalytic residues [active] 1123523007577 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1123523007578 active site 1123523007579 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1123523007580 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1123523007581 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1123523007582 active site turn [active] 1123523007583 phosphorylation site [posttranslational modification] 1123523007584 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1123523007585 HPr interaction site; other site 1123523007586 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1123523007587 active site 1123523007588 phosphorylation site [posttranslational modification] 1123523007589 pyruvate oxidase; Provisional; Region: PRK08611 1123523007590 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1123523007591 PYR/PP interface [polypeptide binding]; other site 1123523007592 tetramer interface [polypeptide binding]; other site 1123523007593 dimer interface [polypeptide binding]; other site 1123523007594 TPP binding site [chemical binding]; other site 1123523007595 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1123523007596 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1123523007597 TPP-binding site [chemical binding]; other site 1123523007598 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1123523007599 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1123523007600 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1123523007601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1123523007602 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1123523007603 putative dimerization interface [polypeptide binding]; other site 1123523007604 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1123523007605 Surface antigen [General function prediction only]; Region: COG3942 1123523007606 CHAP domain; Region: CHAP; pfam05257 1123523007607 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1123523007608 homodimer interface [polypeptide binding]; other site 1123523007609 catalytic residues [active] 1123523007610 NAD binding site [chemical binding]; other site 1123523007611 substrate binding pocket [chemical binding]; other site 1123523007612 flexible flap; other site 1123523007613 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1123523007614 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1123523007615 dimer interface [polypeptide binding]; other site 1123523007616 active site 1123523007617 superantigen-like protein; Reviewed; Region: PRK13037 1123523007618 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 1123523007619 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1123523007620 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1123523007621 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1123523007622 DNA binding site [nucleotide binding] 1123523007623 active site 1123523007624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523007625 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1123523007626 Walker A motif; other site 1123523007627 ATP binding site [chemical binding]; other site 1123523007628 Walker B motif; other site 1123523007629 arginine finger; other site 1123523007630 UvrB/uvrC motif; Region: UVR; pfam02151 1123523007631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1123523007632 Walker A motif; other site 1123523007633 ATP binding site [chemical binding]; other site 1123523007634 Walker B motif; other site 1123523007635 arginine finger; other site 1123523007636 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1123523007637 Virus attachment protein p12 family; Region: P12; pfam12669 1123523007638 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1123523007639 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1123523007640 G1 box; other site 1123523007641 GTP/Mg2+ binding site [chemical binding]; other site 1123523007642 Switch I region; other site 1123523007643 G2 box; other site 1123523007644 G3 box; other site 1123523007645 Switch II region; other site 1123523007646 G4 box; other site 1123523007647 G5 box; other site 1123523007648 Nucleoside recognition; Region: Gate; pfam07670 1123523007649 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1123523007650 Nucleoside recognition; Region: Gate; pfam07670 1123523007651 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1123523007652 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1123523007653 Protein export membrane protein; Region: SecD_SecF; cl14618 1123523007654 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1123523007655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1123523007656 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1123523007657 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1123523007658 Glutamate binding site [chemical binding]; other site 1123523007659 homodimer interface [polypeptide binding]; other site 1123523007660 NAD binding site [chemical binding]; other site 1123523007661 catalytic residues [active] 1123523007662 maltose O-acetyltransferase; Provisional; Region: PRK10092 1123523007663 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1123523007664 active site 1123523007665 substrate binding site [chemical binding]; other site 1123523007666 trimer interface [polypeptide binding]; other site 1123523007667 CoA binding site [chemical binding]; other site 1123523007668 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1123523007669 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1123523007670 metal-binding site [ion binding] 1123523007671 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1123523007672 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1123523007673 metal-binding site [ion binding] 1123523007674 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1123523007675 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1123523007676 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1123523007677 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1123523007678 metal-binding site [ion binding] 1123523007679 D-lactate dehydrogenase; Validated; Region: PRK08605 1123523007680 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1123523007681 homodimer interface [polypeptide binding]; other site 1123523007682 ligand binding site [chemical binding]; other site 1123523007683 NAD binding site [chemical binding]; other site 1123523007684 catalytic site [active] 1123523007685 transaminase; Reviewed; Region: PRK08068 1123523007686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1123523007687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523007688 homodimer interface [polypeptide binding]; other site 1123523007689 catalytic residue [active] 1123523007690 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1123523007691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1123523007692 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1123523007693 active site lid residues [active] 1123523007694 substrate binding pocket [chemical binding]; other site 1123523007695 catalytic residues [active] 1123523007696 substrate-Mg2+ binding site; other site 1123523007697 aspartate-rich region 1; other site 1123523007698 aspartate-rich region 2; other site 1123523007699 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1123523007700 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1123523007701 active site 1123523007702 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1123523007703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1123523007704 Surface antigen [General function prediction only]; Region: COG3942 1123523007705 CHAP domain; Region: CHAP; pfam05257 1123523007706 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1123523007707 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1123523007708 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1123523007709 catalytic triad [active] 1123523007710 catalytic triad [active] 1123523007711 oxyanion hole [active] 1123523007712 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1123523007713 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1123523007714 catalytic residue [active] 1123523007715 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1123523007716 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1123523007717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1123523007718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1123523007719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1123523007720 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1123523007721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1123523007722 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1123523007723 NmrA-like family; Region: NmrA; pfam05368 1123523007724 NADP binding site [chemical binding]; other site 1123523007725 active site 1123523007726 regulatory binding site [polypeptide binding]; other site 1123523007727 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 1123523007728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1123523007729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1123523007730 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 1123523007731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1123523007732 NAD(P) binding site [chemical binding]; other site 1123523007733 active site 1123523007734 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1123523007735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1123523007736 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1123523007737 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1123523007738 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1123523007739 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1123523007740 Nucleoside recognition; Region: Gate; pfam07670 1123523007741 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1123523007742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1123523007743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 1123523007744 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 1123523007745 Phosphotransferase enzyme family; Region: APH; pfam01636 1123523007746 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1123523007747 active site 1123523007748 ATP binding site [chemical binding]; other site 1123523007749 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1123523007750 active site 1123523007751 ATP binding site [chemical binding]; other site 1123523007752 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1123523007753 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1123523007754 quinone interaction residues [chemical binding]; other site 1123523007755 active site 1123523007756 catalytic residues [active] 1123523007757 FMN binding site [chemical binding]; other site 1123523007758 substrate binding site [chemical binding]; other site 1123523007759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1123523007760 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1123523007761 dimer interface [polypeptide binding]; other site 1123523007762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1123523007763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1123523007764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1123523007765 Predicted acyl esterases [General function prediction only]; Region: COG2936 1123523007766 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1123523007767 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1123523007768 tetramerization interface [polypeptide binding]; other site 1123523007769 active site 1123523007770 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1123523007771 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1123523007772 active site 1123523007773 ATP-binding site [chemical binding]; other site 1123523007774 pantoate-binding site; other site 1123523007775 HXXH motif; other site 1123523007776 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1123523007777 oligomerization interface [polypeptide binding]; other site 1123523007778 active site 1123523007779 metal binding site [ion binding]; metal-binding site 1123523007780 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1123523007781 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1123523007782 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1123523007783 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1123523007784 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1123523007785 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1123523007786 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1123523007787 NAD binding site [chemical binding]; other site 1123523007788 dimer interface [polypeptide binding]; other site 1123523007789 substrate binding site [chemical binding]; other site 1123523007790 amino acid transporter; Region: 2A0306; TIGR00909 1123523007791 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1123523007792 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1123523007793 inhibitor-cofactor binding pocket; inhibition site 1123523007794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523007795 catalytic residue [active] 1123523007796 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1123523007797 catalytic residue [active] 1123523007798 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1123523007799 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1123523007800 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1123523007801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1123523007802 acyl-activating enzyme (AAE) consensus motif; other site 1123523007803 AMP binding site [chemical binding]; other site 1123523007804 active site 1123523007805 CoA binding site [chemical binding]; other site 1123523007806 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1123523007807 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 1123523007808 choline dehydrogenase; Validated; Region: PRK02106 1123523007809 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1123523007810 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1123523007811 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1123523007812 tetramerization interface [polypeptide binding]; other site 1123523007813 NAD(P) binding site [chemical binding]; other site 1123523007814 catalytic residues [active] 1123523007815 Predicted transcriptional regulators [Transcription]; Region: COG1510 1123523007816 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1123523007817 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1123523007818 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1123523007819 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1123523007820 FeS/SAM binding site; other site 1123523007821 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 1123523007822 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1123523007823 effector binding site; other site 1123523007824 active site 1123523007825 Zn binding site [ion binding]; other site 1123523007826 glycine loop; other site 1123523007827 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1123523007828 Citrate transporter; Region: CitMHS; pfam03600 1123523007829 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1123523007830 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1123523007831 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1123523007832 Flavodoxin; Region: Flavodoxin_1; pfam00258 1123523007833 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1123523007834 FAD binding pocket [chemical binding]; other site 1123523007835 FAD binding motif [chemical binding]; other site 1123523007836 catalytic residues [active] 1123523007837 NAD binding pocket [chemical binding]; other site 1123523007838 phosphate binding motif [ion binding]; other site 1123523007839 beta-alpha-beta structure motif; other site 1123523007840 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1123523007841 catalytic residues [active] 1123523007842 dimer interface [polypeptide binding]; other site 1123523007843 FtsX-like permease family; Region: FtsX; pfam02687 1123523007844 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1123523007845 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1123523007846 Walker A/P-loop; other site 1123523007847 ATP binding site [chemical binding]; other site 1123523007848 Q-loop/lid; other site 1123523007849 ABC transporter signature motif; other site 1123523007850 Walker B; other site 1123523007851 D-loop; other site 1123523007852 H-loop/switch region; other site 1123523007853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1123523007854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1123523007855 ATP binding site [chemical binding]; other site 1123523007856 Mg2+ binding site [ion binding]; other site 1123523007857 G-X-G motif; other site 1123523007858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1123523007859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1123523007860 active site 1123523007861 phosphorylation site [posttranslational modification] 1123523007862 intermolecular recognition site; other site 1123523007863 dimerization interface [polypeptide binding]; other site 1123523007864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1123523007865 DNA binding site [nucleotide binding] 1123523007866 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1123523007867 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1123523007868 dimer interface [polypeptide binding]; other site 1123523007869 active site 1123523007870 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1123523007871 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1123523007872 MarR family; Region: MarR_2; pfam12802 1123523007873 Predicted esterase [General function prediction only]; Region: COG0627 1123523007874 S-formylglutathione hydrolase; Region: PLN02442 1123523007875 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1123523007876 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 1123523007877 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1123523007878 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1123523007879 ligand binding site [chemical binding]; other site 1123523007880 flexible hinge region; other site 1123523007881 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1123523007882 carbamate kinase; Reviewed; Region: PRK12686 1123523007883 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1123523007884 putative substrate binding site [chemical binding]; other site 1123523007885 nucleotide binding site [chemical binding]; other site 1123523007886 nucleotide binding site [chemical binding]; other site 1123523007887 homodimer interface [polypeptide binding]; other site 1123523007888 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1123523007889 ornithine carbamoyltransferase; Validated; Region: PRK02102 1123523007890 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1123523007891 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1123523007892 arginine deiminase; Provisional; Region: PRK01388 1123523007893 Arginine repressor [Transcription]; Region: ArgR; COG1438 1123523007894 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1123523007895 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1123523007896 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1123523007897 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1123523007898 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1123523007899 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1123523007900 active site 1123523007901 Zn binding site [ion binding]; other site 1123523007902 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1123523007903 HTH domain; Region: HTH_11; pfam08279 1123523007904 PRD domain; Region: PRD; pfam00874 1123523007905 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1123523007906 active site 1123523007907 P-loop; other site 1123523007908 phosphorylation site [posttranslational modification] 1123523007909 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1123523007910 active site 1123523007911 phosphorylation site [posttranslational modification] 1123523007912 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1123523007913 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1123523007914 active site 1123523007915 P-loop; other site 1123523007916 phosphorylation site [posttranslational modification] 1123523007917 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1123523007918 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1123523007919 active site 1123523007920 phosphorylation site [posttranslational modification] 1123523007921 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1123523007922 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1123523007923 Predicted membrane protein [Function unknown]; Region: COG1511 1123523007924 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1123523007925 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1123523007926 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 1123523007927 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1123523007928 CHAP domain; Region: CHAP; pfam05257 1123523007929 Isochorismatase family; Region: Isochorismatase; pfam00857 1123523007930 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1123523007931 catalytic triad [active] 1123523007932 conserved cis-peptide bond; other site 1123523007933 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1123523007934 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1123523007935 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1123523007936 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1123523007937 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1123523007938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1123523007939 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1123523007940 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1123523007941 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1123523007942 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1123523007943 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1123523007944 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 1123523007945 SecY translocase; Region: SecY; pfam00344 1123523007946 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1123523007947 legume lectins; Region: lectin_L-type; cd01951 1123523007948 homotetramer interaction site [polypeptide binding]; other site 1123523007949 carbohydrate binding site [chemical binding]; other site 1123523007950 metal binding site [ion binding]; metal-binding site 1123523007951 Putative Ig domain; Region: He_PIG; pfam05345 1123523007952 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1123523007953 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 1123523007954 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1123523007955 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1123523007956 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1123523007957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1123523007958 Coenzyme A binding pocket [chemical binding]; other site 1123523007959 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1123523007960 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1123523007961 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1123523007962 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1123523007963 Chain length determinant protein; Region: Wzz; cl15801 1123523007964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1123523007965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1123523007966 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1123523007967 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1123523007968 DXD motif; other site 1123523007969 intracellular adhesion protein D; Region: PIA_icaD; TIGR03932 1123523007970 intercellular adhesin biosynthesis polysaccharide N-deacetylase; Region: PIA_icaB; TIGR03933 1123523007971 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1123523007972 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1123523007973 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1123523007974 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1123523007975 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1123523007976 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1123523007977 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1123523007978 metal binding site [ion binding]; metal-binding site 1123523007979 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1123523007980 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1123523007981 substrate binding site [chemical binding]; other site 1123523007982 glutamase interaction surface [polypeptide binding]; other site 1123523007983 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1123523007984 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1123523007985 catalytic residues [active] 1123523007986 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 1123523007987 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1123523007988 putative active site [active] 1123523007989 oxyanion strand; other site 1123523007990 catalytic triad [active] 1123523007991 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1123523007992 putative active site pocket [active] 1123523007993 4-fold oligomerization interface [polypeptide binding]; other site 1123523007994 metal binding residues [ion binding]; metal-binding site 1123523007995 3-fold/trimer interface [polypeptide binding]; other site 1123523007996 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1123523007997 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1123523007998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1123523007999 homodimer interface [polypeptide binding]; other site 1123523008000 catalytic residue [active] 1123523008001 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1123523008002 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1123523008003 NAD binding site [chemical binding]; other site 1123523008004 dimerization interface [polypeptide binding]; other site 1123523008005 product binding site; other site 1123523008006 substrate binding site [chemical binding]; other site 1123523008007 zinc binding site [ion binding]; other site 1123523008008 catalytic residues [active] 1123523008009 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13584 1123523008010 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1123523008011 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12294 1123523008012 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1123523008013 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1123523008014 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1123523008015 putative active site [active] 1123523008016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1123523008017 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1123523008018 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1123523008019 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1123523008020 Walker A/P-loop; other site 1123523008021 ATP binding site [chemical binding]; other site 1123523008022 Q-loop/lid; other site 1123523008023 ABC transporter signature motif; other site 1123523008024 Walker B; other site 1123523008025 D-loop; other site 1123523008026 H-loop/switch region; other site 1123523008027 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1123523008028 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1123523008029 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1123523008030 Walker A/P-loop; other site 1123523008031 ATP binding site [chemical binding]; other site 1123523008032 Q-loop/lid; other site 1123523008033 ABC transporter signature motif; other site 1123523008034 Walker B; other site 1123523008035 D-loop; other site 1123523008036 H-loop/switch region; other site 1123523008037 hypothetical protein; Provisional; Region: PRK13661 1123523008038 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1123523008039 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1123523008040 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1123523008041 Strictosidine synthase; Region: Str_synth; pfam03088 1123523008042 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1123523008043 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1123523008044 active site residue [active] 1123523008045 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1123523008046 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1123523008047 putative substrate binding pocket [chemical binding]; other site 1123523008048 AC domain interface; other site 1123523008049 catalytic triad [active] 1123523008050 AB domain interface; other site 1123523008051 interchain disulfide; other site 1123523008052 hypothetical protein; Validated; Region: PRK07668 1123523008053 Predicted transcriptional regulators [Transcription]; Region: COG1695 1123523008054 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1123523008055 DinB superfamily; Region: DinB_2; pfam12867 1123523008056 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1123523008057 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1123523008058 transmembrane helices; other site 1123523008059 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1123523008060 EamA-like transporter family; Region: EamA; pfam00892 1123523008061 hypothetical protein; Provisional; Region: PRK07758 1123523008062 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1123523008063 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1123523008064 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1123523008065 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1123523008066 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1123523008067 Walker A/P-loop; other site 1123523008068 ATP binding site [chemical binding]; other site 1123523008069 Q-loop/lid; other site 1123523008070 ABC transporter signature motif; other site 1123523008071 Walker B; other site 1123523008072 D-loop; other site 1123523008073 H-loop/switch region; other site 1123523008074 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1123523008075 FtsX-like permease family; Region: FtsX; pfam02687 1123523008076 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1123523008077 DNA-binding site [nucleotide binding]; DNA binding site 1123523008078 RNA-binding motif; other site 1123523008079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1123523008080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1123523008081 non-specific DNA binding site [nucleotide binding]; other site 1123523008082 salt bridge; other site 1123523008083 sequence-specific DNA binding site [nucleotide binding]; other site 1123523008084 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1123523008085 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1123523008086 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1123523008087 ParB-like nuclease domain; Region: ParBc; pfam02195 1123523008088 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1123523008089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1123523008090 S-adenosylmethionine binding site [chemical binding]; other site 1123523008091 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1123523008092 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1123523008093 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1123523008094 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1123523008095 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1123523008096 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1123523008097 G1 box; other site 1123523008098 GTP/Mg2+ binding site [chemical binding]; other site 1123523008099 Switch I region; other site 1123523008100 G2 box; other site 1123523008101 Switch II region; other site 1123523008102 G3 box; other site 1123523008103 G4 box; other site 1123523008104 G5 box; other site 1123523008105 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1123523008106 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1123523008107 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399