-- dump date 20140620_072226 -- class Genbank::misc_feature -- table misc_feature_note -- id note 158189000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 158189000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 158189000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189000004 Walker A motif; other site 158189000005 ATP binding site [chemical binding]; other site 158189000006 Walker B motif; other site 158189000007 arginine finger; other site 158189000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 158189000009 DnaA box-binding interface [nucleotide binding]; other site 158189000010 DNA polymerase III subunit beta; Provisional; Region: PRK14940 158189000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 158189000012 putative DNA binding surface [nucleotide binding]; other site 158189000013 dimer interface [polypeptide binding]; other site 158189000014 beta-clamp/clamp loader binding surface; other site 158189000015 beta-clamp/translesion DNA polymerase binding surface; other site 158189000016 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 158189000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189000018 Walker A/P-loop; other site 158189000019 ATP binding site [chemical binding]; other site 158189000020 Q-loop/lid; other site 158189000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189000022 ABC transporter signature motif; other site 158189000023 Walker B; other site 158189000024 D-loop; other site 158189000025 H-loop/switch region; other site 158189000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 158189000027 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 158189000028 Ribonuclease P; Region: Ribonuclease_P; pfam00825 158189000029 membrane protein insertase; Provisional; Region: PRK01318 158189000030 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 158189000031 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 158189000032 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 158189000033 G-X-X-G motif; other site 158189000034 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 158189000035 RxxxH motif; other site 158189000036 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 158189000037 ATP cone domain; Region: ATP-cone; pfam03477 158189000038 Class III ribonucleotide reductase; Region: RNR_III; cd01675 158189000039 effector binding site; other site 158189000040 active site 158189000041 Zn binding site [ion binding]; other site 158189000042 glycine loop; other site 158189000043 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 158189000044 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189000045 FeS/SAM binding site; other site 158189000046 S-adenosylmethionine synthetase; Validated; Region: PRK05250 158189000047 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 158189000048 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 158189000049 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 158189000050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158189000051 putative DNA binding site [nucleotide binding]; other site 158189000052 putative Zn2+ binding site [ion binding]; other site 158189000053 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158189000054 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 158189000055 substrate binding site [chemical binding]; other site 158189000056 ATP binding site [chemical binding]; other site 158189000057 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 158189000058 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 158189000059 hinge; other site 158189000060 active site 158189000061 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189000062 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189000063 metal binding site [ion binding]; metal-binding site 158189000064 active site 158189000065 I-site; other site 158189000066 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 158189000067 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 158189000068 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 158189000069 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 158189000070 G1 box; other site 158189000071 GTP/Mg2+ binding site [chemical binding]; other site 158189000072 Switch I region; other site 158189000073 G2 box; other site 158189000074 G3 box; other site 158189000075 Switch II region; other site 158189000076 G4 box; other site 158189000077 G5 box; other site 158189000078 Nucleoside recognition; Region: Gate; pfam07670 158189000079 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 158189000080 Nucleoside recognition; Region: Gate; pfam07670 158189000081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189000082 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 158189000083 Walker A motif; other site 158189000084 ATP binding site [chemical binding]; other site 158189000085 Walker B motif; other site 158189000086 arginine finger; other site 158189000087 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 158189000088 C-terminal peptidase (prc); Region: prc; TIGR00225 158189000089 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 158189000090 protein binding site [polypeptide binding]; other site 158189000091 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 158189000092 Catalytic dyad [active] 158189000093 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 158189000094 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 158189000095 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 158189000096 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 158189000097 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 158189000098 active site 158189000099 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 158189000100 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 158189000101 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189000102 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189000103 active site 158189000104 catalytic tetrad [active] 158189000105 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 158189000106 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 158189000107 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 158189000108 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 158189000109 active site 158189000110 catalytic site [active] 158189000111 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 158189000112 putative active site [active] 158189000113 catalytic residue [active] 158189000114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 158189000115 Domain of unknown function DUF39; Region: DUF39; pfam01837 158189000116 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 158189000117 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189000118 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158189000119 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 158189000120 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 158189000121 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 158189000122 substrate binding pocket [chemical binding]; other site 158189000123 dimer interface [polypeptide binding]; other site 158189000124 inhibitor binding site; inhibition site 158189000125 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 158189000126 B12 binding site [chemical binding]; other site 158189000127 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 158189000128 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158189000129 endonuclease III; Region: ENDO3c; smart00478 158189000130 minor groove reading motif; other site 158189000131 helix-hairpin-helix signature motif; other site 158189000132 substrate binding pocket [chemical binding]; other site 158189000133 active site 158189000134 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 158189000135 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 158189000136 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 158189000137 Prephenate dehydratase; Region: PDT; pfam00800 158189000138 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 158189000139 putative L-Phe binding site [chemical binding]; other site 158189000140 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 158189000141 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 158189000142 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 158189000143 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 158189000144 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 158189000145 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 158189000146 HIGH motif; other site 158189000147 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 158189000148 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158189000149 active site 158189000150 KMSKS motif; other site 158189000151 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 158189000152 tRNA binding surface [nucleotide binding]; other site 158189000153 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 158189000154 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 158189000155 Domain of unknown function DUF21; Region: DUF21; pfam01595 158189000156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 158189000157 Transporter associated domain; Region: CorC_HlyC; smart01091 158189000158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189000159 Coenzyme A binding pocket [chemical binding]; other site 158189000160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189000161 Coenzyme A binding pocket [chemical binding]; other site 158189000162 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 158189000163 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 158189000164 oligomer interface [polypeptide binding]; other site 158189000165 metal binding site [ion binding]; metal-binding site 158189000166 metal binding site [ion binding]; metal-binding site 158189000167 Cl binding site [ion binding]; other site 158189000168 aspartate ring; other site 158189000169 basic sphincter; other site 158189000170 putative hydrophobic gate; other site 158189000171 periplasmic entrance; other site 158189000172 YhhN-like protein; Region: YhhN; cl01505 158189000173 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 158189000174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 158189000175 ATP binding site [chemical binding]; other site 158189000176 Mg2+ binding site [ion binding]; other site 158189000177 G-X-G motif; other site 158189000178 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 158189000179 ATP binding site [chemical binding]; other site 158189000180 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 158189000181 active site 158189000182 putative metal-binding site [ion binding]; other site 158189000183 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 158189000184 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 158189000185 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 158189000186 CAP-like domain; other site 158189000187 active site 158189000188 primary dimer interface [polypeptide binding]; other site 158189000189 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 158189000190 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158189000191 active site 158189000192 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 158189000193 transketolase; Reviewed; Region: PRK05899 158189000194 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158189000195 TPP-binding site [chemical binding]; other site 158189000196 dimer interface [polypeptide binding]; other site 158189000197 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 158189000198 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158189000199 PYR/PP interface [polypeptide binding]; other site 158189000200 dimer interface [polypeptide binding]; other site 158189000201 TPP binding site [chemical binding]; other site 158189000202 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158189000203 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189000204 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158189000205 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 158189000206 DctM-like transporters; Region: DctM; pfam06808 158189000207 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189000208 Class I aldolases; Region: Aldolase_Class_I; cl17187 158189000209 catalytic residue [active] 158189000210 Cupin domain; Region: Cupin_2; pfam07883 158189000211 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158189000212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189000213 DNA-binding site [nucleotide binding]; DNA binding site 158189000214 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 158189000215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 158189000216 phosphorylation site [posttranslational modification] 158189000217 intermolecular recognition site; other site 158189000218 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 158189000219 glutamate dehydrogenase; Provisional; Region: PRK09414 158189000220 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 158189000221 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 158189000222 NAD(P) binding site [chemical binding]; other site 158189000223 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 158189000224 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 158189000225 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 158189000226 active site 158189000227 dimer interface [polypeptide binding]; other site 158189000228 effector binding site; other site 158189000229 TSCPD domain; Region: TSCPD; pfam12637 158189000230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189000231 putative substrate translocation pore; other site 158189000232 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 158189000233 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 158189000234 dimer interface [polypeptide binding]; other site 158189000235 PYR/PP interface [polypeptide binding]; other site 158189000236 TPP binding site [chemical binding]; other site 158189000237 substrate binding site [chemical binding]; other site 158189000238 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 158189000239 Domain of unknown function; Region: EKR; pfam10371 158189000240 4Fe-4S binding domain; Region: Fer4_6; pfam12837 158189000241 4Fe-4S binding domain; Region: Fer4; pfam00037 158189000242 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 158189000243 TPP-binding site [chemical binding]; other site 158189000244 PEGA domain; Region: PEGA; pfam08308 158189000245 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 158189000246 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 158189000247 ligand binding site [chemical binding]; other site 158189000248 calcium binding site [ion binding]; other site 158189000249 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189000250 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189000251 Walker A/P-loop; other site 158189000252 ATP binding site [chemical binding]; other site 158189000253 Q-loop/lid; other site 158189000254 ABC transporter signature motif; other site 158189000255 Walker B; other site 158189000256 D-loop; other site 158189000257 H-loop/switch region; other site 158189000258 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189000259 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189000260 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189000261 TM-ABC transporter signature motif; other site 158189000262 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 158189000263 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 158189000264 substrate binding site [chemical binding]; other site 158189000265 hexamer interface [polypeptide binding]; other site 158189000266 metal binding site [ion binding]; metal-binding site 158189000267 KduI/IolB family; Region: KduI; cl01508 158189000268 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158189000269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189000270 DNA-binding site [nucleotide binding]; DNA binding site 158189000271 FCD domain; Region: FCD; pfam07729 158189000272 DctM-like transporters; Region: DctM; pfam06808 158189000273 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189000274 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158189000275 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189000276 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158189000277 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189000278 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189000279 Cache domain; Region: Cache_1; pfam02743 158189000280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189000281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158189000282 dimerization interface [polypeptide binding]; other site 158189000283 Histidine kinase; Region: His_kinase; pfam06580 158189000284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189000285 ATP binding site [chemical binding]; other site 158189000286 Mg2+ binding site [ion binding]; other site 158189000287 G-X-G motif; other site 158189000288 Response regulator receiver domain; Region: Response_reg; pfam00072 158189000289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189000290 active site 158189000291 phosphorylation site [posttranslational modification] 158189000292 intermolecular recognition site; other site 158189000293 dimerization interface [polypeptide binding]; other site 158189000294 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189000295 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189000296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189000297 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 158189000298 FMN binding site [chemical binding]; other site 158189000299 dimer interface [polypeptide binding]; other site 158189000300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189000301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158189000302 putative substrate translocation pore; other site 158189000303 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 158189000304 FMN binding site [chemical binding]; other site 158189000305 dimer interface [polypeptide binding]; other site 158189000306 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 158189000307 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 158189000308 Rubredoxin; Region: Rubredoxin; pfam00301 158189000309 iron binding site [ion binding]; other site 158189000310 Predicted transcriptional regulator [Transcription]; Region: COG2378 158189000311 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 158189000312 DNA-binding interface [nucleotide binding]; DNA binding site 158189000313 WYL domain; Region: WYL; pfam13280 158189000314 SlyX; Region: SlyX; pfam04102 158189000315 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 158189000316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158189000317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189000318 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158189000319 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 158189000320 active site residue [active] 158189000321 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 158189000322 CPxP motif; other site 158189000323 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 158189000324 MarR family; Region: MarR_2; cl17246 158189000325 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 158189000326 DctM-like transporters; Region: DctM; pfam06808 158189000327 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189000328 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189000329 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189000330 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158189000331 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189000332 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189000333 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158189000334 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189000335 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158189000336 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158189000337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189000338 DNA-binding site [nucleotide binding]; DNA binding site 158189000339 FCD domain; Region: FCD; pfam07729 158189000340 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 158189000341 active site 158189000342 catalytic triad [active] 158189000343 oxyanion hole [active] 158189000344 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 158189000345 putative catalytic site [active] 158189000346 putative metal binding site [ion binding]; other site 158189000347 putative phosphate binding site [ion binding]; other site 158189000348 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189000349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000350 dimer interface [polypeptide binding]; other site 158189000351 conserved gate region; other site 158189000352 putative PBP binding loops; other site 158189000353 ABC-ATPase subunit interface; other site 158189000354 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189000355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000356 dimer interface [polypeptide binding]; other site 158189000357 conserved gate region; other site 158189000358 putative PBP binding loops; other site 158189000359 ABC-ATPase subunit interface; other site 158189000360 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189000361 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158189000362 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189000363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189000364 DNA binding site [nucleotide binding] 158189000365 domain linker motif; other site 158189000366 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189000367 dimerization interface [polypeptide binding]; other site 158189000368 ligand binding site [chemical binding]; other site 158189000369 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 158189000370 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 158189000371 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 158189000372 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 158189000373 putative trimer interface [polypeptide binding]; other site 158189000374 putative CoA binding site [chemical binding]; other site 158189000375 Predicted transcriptional regulators [Transcription]; Region: COG1695 158189000376 Transcriptional regulator PadR-like family; Region: PadR; cl17335 158189000377 CTP synthetase; Validated; Region: pyrG; PRK05380 158189000378 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 158189000379 Catalytic site [active] 158189000380 active site 158189000381 UTP binding site [chemical binding]; other site 158189000382 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 158189000383 active site 158189000384 putative oxyanion hole; other site 158189000385 catalytic triad [active] 158189000386 ANTAR domain; Region: ANTAR; pfam03861 158189000387 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 158189000388 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 158189000389 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 158189000390 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 158189000391 domain_subunit interface; other site 158189000392 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 158189000393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189000394 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189000395 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189000396 4Fe-4S binding domain; Region: Fer4; pfam00037 158189000397 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 158189000398 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 158189000399 active site 158189000400 FMN binding site [chemical binding]; other site 158189000401 substrate binding site [chemical binding]; other site 158189000402 3Fe-4S cluster binding site [ion binding]; other site 158189000403 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 158189000404 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 158189000405 putative active site [active] 158189000406 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 158189000407 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 158189000408 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 158189000409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 158189000410 PAS fold; Region: PAS_4; pfam08448 158189000411 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189000412 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189000413 metal binding site [ion binding]; metal-binding site 158189000414 active site 158189000415 I-site; other site 158189000416 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 158189000417 PAS domain S-box; Region: sensory_box; TIGR00229 158189000418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189000419 putative active site [active] 158189000420 heme pocket [chemical binding]; other site 158189000421 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189000422 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189000423 metal binding site [ion binding]; metal-binding site 158189000424 active site 158189000425 I-site; other site 158189000426 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189000427 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 158189000428 Zn2+ binding site [ion binding]; other site 158189000429 Mg2+ binding site [ion binding]; other site 158189000430 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 158189000431 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 158189000432 active site 158189000433 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 158189000434 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158189000435 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 158189000436 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 158189000437 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 158189000438 heterotetramer interface [polypeptide binding]; other site 158189000439 active site pocket [active] 158189000440 cleavage site 158189000441 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 158189000442 feedback inhibition sensing region; other site 158189000443 homohexameric interface [polypeptide binding]; other site 158189000444 nucleotide binding site [chemical binding]; other site 158189000445 N-acetyl-L-glutamate binding site [chemical binding]; other site 158189000446 acetylornithine aminotransferase; Provisional; Region: PRK02627 158189000447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158189000448 inhibitor-cofactor binding pocket; inhibition site 158189000449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189000450 catalytic residue [active] 158189000451 asparagine synthetase B; Provisional; Region: asnB; PRK09431 158189000452 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 158189000453 active site 158189000454 dimer interface [polypeptide binding]; other site 158189000455 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 158189000456 Ligand Binding Site [chemical binding]; other site 158189000457 Molecular Tunnel; other site 158189000458 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 158189000459 Cadmium resistance transporter; Region: Cad; pfam03596 158189000460 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158189000461 MarR family; Region: MarR_2; pfam12802 158189000462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189000463 DNA binding site [nucleotide binding] 158189000464 domain linker motif; other site 158189000465 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158189000466 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189000467 ligand binding site [chemical binding]; other site 158189000468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189000469 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189000470 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189000471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000472 dimer interface [polypeptide binding]; other site 158189000473 conserved gate region; other site 158189000474 putative PBP binding loops; other site 158189000475 ABC-ATPase subunit interface; other site 158189000476 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189000477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000478 dimer interface [polypeptide binding]; other site 158189000479 conserved gate region; other site 158189000480 putative PBP binding loops; other site 158189000481 ABC-ATPase subunit interface; other site 158189000482 putative alpha-glucosidase; Provisional; Region: PRK10658 158189000483 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 158189000484 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 158189000485 active site 158189000486 homotrimer interface [polypeptide binding]; other site 158189000487 catalytic site [active] 158189000488 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 158189000489 AAA domain; Region: AAA_14; pfam13173 158189000490 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 158189000491 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 158189000492 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 158189000493 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 158189000494 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 158189000495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189000496 S-adenosylmethionine binding site [chemical binding]; other site 158189000497 Divergent AAA domain; Region: AAA_4; pfam04326 158189000498 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 158189000499 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 158189000500 MarR family; Region: MarR_2; pfam12802 158189000501 RelB antitoxin; Region: RelB; cl01171 158189000502 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 158189000503 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 158189000504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158189000505 NAD(P) binding site [chemical binding]; other site 158189000506 active site 158189000507 Predicted acetyltransferase [General function prediction only]; Region: COG5628 158189000508 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 158189000509 Beta-lactamase; Region: Beta-lactamase; pfam00144 158189000510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189000511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189000512 FtsX-like permease family; Region: FtsX; pfam02687 158189000513 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158189000514 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158189000515 Walker A/P-loop; other site 158189000516 ATP binding site [chemical binding]; other site 158189000517 Q-loop/lid; other site 158189000518 ABC transporter signature motif; other site 158189000519 Walker B; other site 158189000520 D-loop; other site 158189000521 H-loop/switch region; other site 158189000522 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 158189000523 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158189000524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189000525 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189000526 non-specific DNA binding site [nucleotide binding]; other site 158189000527 salt bridge; other site 158189000528 sequence-specific DNA binding site [nucleotide binding]; other site 158189000529 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 158189000530 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 158189000531 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 158189000532 catalytic residues [active] 158189000533 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 158189000534 AAA domain; Region: AAA_14; pfam13173 158189000535 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 158189000536 Domain of unknown function (DU1801); Region: DUF1801; cl17490 158189000537 Methyltransferase domain; Region: Methyltransf_31; pfam13847 158189000538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189000539 S-adenosylmethionine binding site [chemical binding]; other site 158189000540 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158189000541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189000542 Coenzyme A binding pocket [chemical binding]; other site 158189000543 Peptidase family M23; Region: Peptidase_M23; pfam01551 158189000544 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 158189000545 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 158189000546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189000547 H+ Antiporter protein; Region: 2A0121; TIGR00900 158189000548 putative substrate translocation pore; other site 158189000549 peptidase; Reviewed; Region: PRK13004 158189000550 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 158189000551 putative metal binding site [ion binding]; other site 158189000552 putative dimer interface [polypeptide binding]; other site 158189000553 CHASE3 domain; Region: CHASE3; pfam05227 158189000554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189000555 PAS fold; Region: PAS_3; pfam08447 158189000556 putative active site [active] 158189000557 heme pocket [chemical binding]; other site 158189000558 PAS domain S-box; Region: sensory_box; TIGR00229 158189000559 PAS fold; Region: PAS; pfam00989 158189000560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189000561 putative active site [active] 158189000562 heme pocket [chemical binding]; other site 158189000563 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189000564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189000565 metal binding site [ion binding]; metal-binding site 158189000566 active site 158189000567 I-site; other site 158189000568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189000569 Zn2+ binding site [ion binding]; other site 158189000570 Mg2+ binding site [ion binding]; other site 158189000571 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158189000572 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189000573 peroxiredoxin; Provisional; Region: PRK13189 158189000574 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 158189000575 dimer interface [polypeptide binding]; other site 158189000576 decamer (pentamer of dimers) interface [polypeptide binding]; other site 158189000577 catalytic triad [active] 158189000578 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189000579 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 158189000580 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 158189000581 Cupin domain; Region: Cupin_2; cl17218 158189000582 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158189000583 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158189000584 ligand binding site [chemical binding]; other site 158189000585 flexible hinge region; other site 158189000586 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 158189000587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 158189000588 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 158189000589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 158189000590 Predicted membrane protein [Function unknown]; Region: COG4129 158189000591 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189000592 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189000593 ligand binding site [chemical binding]; other site 158189000594 dimerization interface [polypeptide binding]; other site 158189000595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 158189000596 Histidine kinase; Region: HisKA_3; pfam07730 158189000597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189000598 ATP binding site [chemical binding]; other site 158189000599 Mg2+ binding site [ion binding]; other site 158189000600 G-X-G motif; other site 158189000601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189000602 Response regulator receiver domain; Region: Response_reg; pfam00072 158189000603 active site 158189000604 phosphorylation site [posttranslational modification] 158189000605 intermolecular recognition site; other site 158189000606 dimerization interface [polypeptide binding]; other site 158189000607 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 158189000608 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 158189000609 putative ligand binding site [chemical binding]; other site 158189000610 putative NAD binding site [chemical binding]; other site 158189000611 catalytic site [active] 158189000612 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 158189000613 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 158189000614 dimer interface [polypeptide binding]; other site 158189000615 active site 158189000616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158189000617 catalytic residues [active] 158189000618 substrate binding site [chemical binding]; other site 158189000619 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 158189000620 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 158189000621 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158189000622 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158189000623 inhibitor site; inhibition site 158189000624 active site 158189000625 dimer interface [polypeptide binding]; other site 158189000626 catalytic residue [active] 158189000627 AAA domain; Region: AAA_14; pfam13173 158189000628 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 158189000629 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 158189000630 Transcriptional regulator [Transcription]; Region: IclR; COG1414 158189000631 Bacterial transcriptional regulator; Region: IclR; pfam01614 158189000632 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 158189000633 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 158189000634 active site 158189000635 tetramer interface [polypeptide binding]; other site 158189000636 Membrane transport protein; Region: Mem_trans; cl09117 158189000637 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 158189000638 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 158189000639 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 158189000640 galactarate dehydratase; Region: galactar-dH20; TIGR03248 158189000641 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 158189000642 TIGR04076 family protein; Region: TIGR04076 158189000643 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 158189000644 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 158189000645 active site 158189000646 dimer interface [polypeptide binding]; other site 158189000647 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158189000648 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 158189000649 active site 158189000650 trimer interface [polypeptide binding]; other site 158189000651 allosteric site; other site 158189000652 active site lid [active] 158189000653 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158189000654 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189000655 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158189000656 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158189000657 DctM-like transporters; Region: DctM; pfam06808 158189000658 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189000659 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158189000660 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 158189000661 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189000662 DNA-binding interface [nucleotide binding]; DNA binding site 158189000663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189000664 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189000665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189000666 non-specific DNA binding site [nucleotide binding]; other site 158189000667 salt bridge; other site 158189000668 sequence-specific DNA binding site [nucleotide binding]; other site 158189000669 Domain of unknown function (DUF955); Region: DUF955; cl01076 158189000670 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158189000671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189000672 Walker A/P-loop; other site 158189000673 ATP binding site [chemical binding]; other site 158189000674 Q-loop/lid; other site 158189000675 ABC transporter signature motif; other site 158189000676 Walker B; other site 158189000677 D-loop; other site 158189000678 H-loop/switch region; other site 158189000679 TOBE domain; Region: TOBE_2; pfam08402 158189000680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158189000681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189000682 dimer interface [polypeptide binding]; other site 158189000683 phosphorylation site [posttranslational modification] 158189000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189000685 ATP binding site [chemical binding]; other site 158189000686 Mg2+ binding site [ion binding]; other site 158189000687 G-X-G motif; other site 158189000688 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158189000689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189000690 active site 158189000691 phosphorylation site [posttranslational modification] 158189000692 intermolecular recognition site; other site 158189000693 dimerization interface [polypeptide binding]; other site 158189000694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158189000695 DNA binding site [nucleotide binding] 158189000696 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189000697 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158189000698 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158189000699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000700 dimer interface [polypeptide binding]; other site 158189000701 conserved gate region; other site 158189000702 putative PBP binding loops; other site 158189000703 ABC-ATPase subunit interface; other site 158189000704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000705 dimer interface [polypeptide binding]; other site 158189000706 conserved gate region; other site 158189000707 putative PBP binding loops; other site 158189000708 ABC-ATPase subunit interface; other site 158189000709 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158189000710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189000711 Walker A/P-loop; other site 158189000712 ATP binding site [chemical binding]; other site 158189000713 Q-loop/lid; other site 158189000714 ABC transporter signature motif; other site 158189000715 Walker B; other site 158189000716 D-loop; other site 158189000717 H-loop/switch region; other site 158189000718 TOBE domain; Region: TOBE_2; pfam08402 158189000719 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 158189000720 AAA domain; Region: AAA_14; pfam13173 158189000721 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 158189000722 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189000723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000724 dimer interface [polypeptide binding]; other site 158189000725 conserved gate region; other site 158189000726 putative PBP binding loops; other site 158189000727 ABC-ATPase subunit interface; other site 158189000728 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189000729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000730 dimer interface [polypeptide binding]; other site 158189000731 conserved gate region; other site 158189000732 putative PBP binding loops; other site 158189000733 ABC-ATPase subunit interface; other site 158189000734 Probable beta-xylosidase; Provisional; Region: PLN03080 158189000735 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 158189000736 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 158189000737 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189000738 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189000739 Cupin domain; Region: Cupin_2; pfam07883 158189000740 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 158189000741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189000742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189000743 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189000744 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189000745 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158189000746 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 158189000747 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 158189000748 metal binding site [ion binding]; metal-binding site 158189000749 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 158189000750 Domain of unknown function (DUF303); Region: DUF303; pfam03629 158189000751 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 158189000752 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 158189000753 CPxP motif; other site 158189000754 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 158189000755 selenophosphate synthetase; Provisional; Region: PRK00943 158189000756 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 158189000757 dimerization interface [polypeptide binding]; other site 158189000758 putative ATP binding site [chemical binding]; other site 158189000759 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 158189000760 AAA domain; Region: AAA_14; pfam13173 158189000761 AAA domain; Region: AAA_14; pfam13173 158189000762 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 158189000763 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 158189000764 Divergent AAA domain; Region: AAA_4; pfam04326 158189000765 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 158189000766 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 158189000767 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 158189000768 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 158189000769 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 158189000770 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 158189000771 shikimate binding site; other site 158189000772 NAD(P) binding site [chemical binding]; other site 158189000773 Transcription antiterminator [Transcription]; Region: NusG; COG0250 158189000774 In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold; Region: NGN; smart00738 158189000775 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 158189000776 heterodimer interface [polypeptide binding]; other site 158189000777 homodimer interface [polypeptide binding]; other site 158189000778 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 158189000779 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 158189000780 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 158189000781 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 158189000782 NAD(P) binding site [chemical binding]; other site 158189000783 homodimer interface [polypeptide binding]; other site 158189000784 substrate binding site [chemical binding]; other site 158189000785 active site 158189000786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189000787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189000788 AAA domain; Region: AAA_21; pfam13304 158189000789 Walker A/P-loop; other site 158189000790 Walker A/P-loop; other site 158189000791 ATP binding site [chemical binding]; other site 158189000792 ATP binding site [chemical binding]; other site 158189000793 Q-loop/lid; other site 158189000794 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 158189000795 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 158189000796 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 158189000797 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 158189000798 active site 158189000799 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189000800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000801 dimer interface [polypeptide binding]; other site 158189000802 conserved gate region; other site 158189000803 putative PBP binding loops; other site 158189000804 ABC-ATPase subunit interface; other site 158189000805 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189000806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000807 dimer interface [polypeptide binding]; other site 158189000808 conserved gate region; other site 158189000809 putative PBP binding loops; other site 158189000810 ABC-ATPase subunit interface; other site 158189000811 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189000812 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189000813 MarR family; Region: MarR_2; pfam12802 158189000814 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158189000815 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158189000816 nucleotide binding site [chemical binding]; other site 158189000817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189000818 Walker A/P-loop; other site 158189000819 ATP binding site [chemical binding]; other site 158189000820 AAA domain; Region: AAA_21; pfam13304 158189000821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 158189000822 ABC transporter signature motif; other site 158189000823 Walker B; other site 158189000824 D-loop; other site 158189000825 H-loop/switch region; other site 158189000826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189000827 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 158189000828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189000829 non-specific DNA binding site [nucleotide binding]; other site 158189000830 salt bridge; other site 158189000831 sequence-specific DNA binding site [nucleotide binding]; other site 158189000832 Domain of unknown function (DUF955); Region: DUF955; pfam06114 158189000833 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 158189000834 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 158189000835 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 158189000836 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 158189000837 putative active site [active] 158189000838 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189000839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000840 dimer interface [polypeptide binding]; other site 158189000841 conserved gate region; other site 158189000842 putative PBP binding loops; other site 158189000843 ABC-ATPase subunit interface; other site 158189000844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189000845 dimer interface [polypeptide binding]; other site 158189000846 conserved gate region; other site 158189000847 ABC-ATPase subunit interface; other site 158189000848 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189000849 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189000850 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158189000851 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158189000852 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158189000853 putative active site [active] 158189000854 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 158189000855 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 158189000856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 158189000857 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 158189000858 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158189000859 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189000860 catalytic residue [active] 158189000861 Bacterial sugar transferase; Region: Bac_transf; pfam02397 158189000862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158189000863 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 158189000864 NAD(P) binding site [chemical binding]; other site 158189000865 active site 158189000866 putative glycosyl transferase; Provisional; Region: PRK10307 158189000867 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 158189000868 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 158189000869 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 158189000870 NAD(P) binding site [chemical binding]; other site 158189000871 homodimer interface [polypeptide binding]; other site 158189000872 substrate binding site [chemical binding]; other site 158189000873 active site 158189000874 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 158189000875 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 158189000876 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 158189000877 putative NAD(P) binding site [chemical binding]; other site 158189000878 active site 158189000879 putative substrate binding site [chemical binding]; other site 158189000880 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 158189000881 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 158189000882 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 158189000883 active site 158189000884 homodimer interface [polypeptide binding]; other site 158189000885 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158189000886 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 158189000887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158189000888 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158189000889 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 158189000890 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 158189000891 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 158189000892 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 158189000893 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 158189000894 NAD binding site [chemical binding]; other site 158189000895 substrate binding site [chemical binding]; other site 158189000896 homodimer interface [polypeptide binding]; other site 158189000897 active site 158189000898 putative glycosyl transferase; Provisional; Region: PRK10073 158189000899 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 158189000900 active site 158189000901 LicD family; Region: LicD; cl01378 158189000902 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 158189000903 active site 158189000904 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 158189000905 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158189000906 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189000907 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 158189000908 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 158189000909 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 158189000910 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158189000911 active site 158189000912 KMSKS motif; other site 158189000913 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 158189000914 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 158189000915 tetramer interface [polypeptide binding]; other site 158189000916 active site 158189000917 Mg2+/Mn2+ binding site [ion binding]; other site 158189000918 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 158189000919 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 158189000920 PYR/PP interface [polypeptide binding]; other site 158189000921 dimer interface [polypeptide binding]; other site 158189000922 TPP binding site [chemical binding]; other site 158189000923 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 158189000924 TPP-binding site; other site 158189000925 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 158189000926 active site 158189000927 metal-binding site 158189000928 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158189000929 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189000930 catalytic residue [active] 158189000931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 158189000932 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 158189000933 Walker A motif; other site 158189000934 ATP binding site [chemical binding]; other site 158189000935 Walker B motif; other site 158189000936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 158189000937 Integrase core domain; Region: rve; pfam00665 158189000938 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189000939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189000940 non-specific DNA binding site [nucleotide binding]; other site 158189000941 salt bridge; other site 158189000942 sequence-specific DNA binding site [nucleotide binding]; other site 158189000943 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189000944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189000945 non-specific DNA binding site [nucleotide binding]; other site 158189000946 salt bridge; other site 158189000947 sequence-specific DNA binding site [nucleotide binding]; other site 158189000948 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 158189000949 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 158189000950 BRO family, N-terminal domain; Region: Bro-N; pfam02498 158189000951 Replicase family; Region: Replicase; pfam03090 158189000952 Domain of unknown function (DUF927); Region: DUF927; cl12098 158189000953 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 158189000954 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 158189000955 putative active site pocket [active] 158189000956 dimerization interface [polypeptide binding]; other site 158189000957 putative catalytic residue [active] 158189000958 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158189000959 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 158189000960 catalytic residues [active] 158189000961 catalytic nucleophile [active] 158189000962 Recombinase; Region: Recombinase; pfam07508 158189000963 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158189000964 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 158189000965 catalytic residues [active] 158189000966 catalytic nucleophile [active] 158189000967 Recombinase; Region: Recombinase; pfam07508 158189000968 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 158189000969 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158189000970 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 158189000971 catalytic residues [active] 158189000972 catalytic nucleophile [active] 158189000973 Recombinase; Region: Recombinase; pfam07508 158189000974 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 158189000975 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 158189000976 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 158189000977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189000978 non-specific DNA binding site [nucleotide binding]; other site 158189000979 salt bridge; other site 158189000980 sequence-specific DNA binding site [nucleotide binding]; other site 158189000981 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158189000982 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 158189000983 catalytic residues [active] 158189000984 catalytic nucleophile [active] 158189000985 Recombinase; Region: Recombinase; pfam07508 158189000986 Archaeal ATPase; Region: Arch_ATPase; pfam01637 158189000987 AAA domain; Region: AAA_14; pfam13173 158189000988 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 158189000989 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158189000990 hypothetical protein; Validated; Region: PRK07668 158189000991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158189000992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158189000993 DNA binding residues [nucleotide binding] 158189000994 dimerization interface [polypeptide binding]; other site 158189000995 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 158189000996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189000997 non-specific DNA binding site [nucleotide binding]; other site 158189000998 salt bridge; other site 158189000999 sequence-specific DNA binding site [nucleotide binding]; other site 158189001000 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 158189001001 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 158189001002 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 158189001003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189001004 DNA-binding site [nucleotide binding]; DNA binding site 158189001005 UTRA domain; Region: UTRA; pfam07702 158189001006 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189001007 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158189001008 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158189001009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001010 dimer interface [polypeptide binding]; other site 158189001011 conserved gate region; other site 158189001012 putative PBP binding loops; other site 158189001013 ABC-ATPase subunit interface; other site 158189001014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001015 dimer interface [polypeptide binding]; other site 158189001016 conserved gate region; other site 158189001017 putative PBP binding loops; other site 158189001018 ABC-ATPase subunit interface; other site 158189001019 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 158189001020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189001021 Walker A/P-loop; other site 158189001022 ATP binding site [chemical binding]; other site 158189001023 Q-loop/lid; other site 158189001024 ABC transporter signature motif; other site 158189001025 Walker B; other site 158189001026 D-loop; other site 158189001027 H-loop/switch region; other site 158189001028 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 158189001029 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 158189001030 active site 158189001031 dimerization interface [polypeptide binding]; other site 158189001032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189001033 AAA ATPase domain; Region: AAA_15; pfam13175 158189001034 Walker A/P-loop; other site 158189001035 ATP binding site [chemical binding]; other site 158189001036 Q-loop/lid; other site 158189001037 RloB-like protein; Region: RloB; pfam13707 158189001038 TfoX C-terminal domain; Region: TfoX_C; pfam04994 158189001039 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 158189001040 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 158189001041 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 158189001042 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158189001043 substrate binding site [chemical binding]; other site 158189001044 ATP binding site [chemical binding]; other site 158189001045 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 158189001046 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 158189001047 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001048 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189001049 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158189001050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189001051 active site 158189001052 phosphorylation site [posttranslational modification] 158189001053 intermolecular recognition site; other site 158189001054 dimerization interface [polypeptide binding]; other site 158189001055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158189001056 DNA binding residues [nucleotide binding] 158189001057 dimerization interface [polypeptide binding]; other site 158189001058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189001059 Histidine kinase; Region: HisKA_3; pfam07730 158189001060 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 158189001061 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158189001062 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158189001063 ligand binding site [chemical binding]; other site 158189001064 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189001065 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189001066 Walker A/P-loop; other site 158189001067 ATP binding site [chemical binding]; other site 158189001068 Q-loop/lid; other site 158189001069 ABC transporter signature motif; other site 158189001070 Walker B; other site 158189001071 D-loop; other site 158189001072 H-loop/switch region; other site 158189001073 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189001074 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189001075 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189001076 TM-ABC transporter signature motif; other site 158189001077 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 158189001078 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 158189001079 AAA domain; Region: AAA_14; pfam13173 158189001080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189001081 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158189001082 dimerization interface [polypeptide binding]; other site 158189001083 Histidine kinase; Region: His_kinase; pfam06580 158189001084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189001085 ATP binding site [chemical binding]; other site 158189001086 Mg2+ binding site [ion binding]; other site 158189001087 G-X-G motif; other site 158189001088 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 158189001089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189001090 active site 158189001091 phosphorylation site [posttranslational modification] 158189001092 intermolecular recognition site; other site 158189001093 dimerization interface [polypeptide binding]; other site 158189001094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189001095 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001098 dimer interface [polypeptide binding]; other site 158189001099 conserved gate region; other site 158189001100 putative PBP binding loops; other site 158189001101 ABC-ATPase subunit interface; other site 158189001102 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001104 dimer interface [polypeptide binding]; other site 158189001105 conserved gate region; other site 158189001106 putative PBP binding loops; other site 158189001107 ABC-ATPase subunit interface; other site 158189001108 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 158189001109 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189001110 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189001111 active site 158189001112 catalytic tetrad [active] 158189001113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189001114 non-specific DNA binding site [nucleotide binding]; other site 158189001115 salt bridge; other site 158189001116 sequence-specific DNA binding site [nucleotide binding]; other site 158189001117 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001118 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001120 dimer interface [polypeptide binding]; other site 158189001121 conserved gate region; other site 158189001122 ABC-ATPase subunit interface; other site 158189001123 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189001124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001125 dimer interface [polypeptide binding]; other site 158189001126 conserved gate region; other site 158189001127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158189001128 ABC-ATPase subunit interface; other site 158189001129 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 158189001130 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 158189001131 metal binding site [ion binding]; metal-binding site 158189001132 substrate binding pocket [chemical binding]; other site 158189001133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189001134 DNA-binding site [nucleotide binding]; DNA binding site 158189001135 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 158189001136 FCD domain; Region: FCD; pfam07729 158189001137 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158189001138 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 158189001139 putative NAD(P) binding site [chemical binding]; other site 158189001140 catalytic Zn binding site [ion binding]; other site 158189001141 structural Zn binding site [ion binding]; other site 158189001142 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 158189001143 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 158189001144 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 158189001145 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 158189001146 Histidine kinase; Region: His_kinase; pfam06580 158189001147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189001148 ATP binding site [chemical binding]; other site 158189001149 Mg2+ binding site [ion binding]; other site 158189001150 G-X-G motif; other site 158189001151 Response regulator receiver domain; Region: Response_reg; pfam00072 158189001152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189001153 active site 158189001154 phosphorylation site [posttranslational modification] 158189001155 intermolecular recognition site; other site 158189001156 dimerization interface [polypeptide binding]; other site 158189001157 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189001158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189001159 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001160 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001161 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189001162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001163 dimer interface [polypeptide binding]; other site 158189001164 conserved gate region; other site 158189001165 putative PBP binding loops; other site 158189001166 ABC-ATPase subunit interface; other site 158189001167 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001169 dimer interface [polypeptide binding]; other site 158189001170 conserved gate region; other site 158189001171 putative PBP binding loops; other site 158189001172 ABC-ATPase subunit interface; other site 158189001173 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 158189001174 Sulfatase; Region: Sulfatase; cl17466 158189001175 amino acid transporter; Region: 2A0306; TIGR00909 158189001176 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158189001177 active site 158189001178 HIGH motif; other site 158189001179 nucleotide binding site [chemical binding]; other site 158189001180 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158189001181 active site 158189001182 KMSKS motif; other site 158189001183 Riboflavin kinase; Region: Flavokinase; pfam01687 158189001184 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 158189001185 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 158189001186 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 158189001187 CoA binding domain; Region: CoA_binding; cl17356 158189001188 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 158189001189 NAD(P) binding site [chemical binding]; other site 158189001190 homodimer interface [polypeptide binding]; other site 158189001191 substrate binding site [chemical binding]; other site 158189001192 active site 158189001193 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 158189001194 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 158189001195 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 158189001196 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158189001197 catalytic residue [active] 158189001198 Bacterial sugar transferase; Region: Bac_transf; pfam02397 158189001199 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 158189001200 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 158189001201 homodimer interface [polypeptide binding]; other site 158189001202 substrate-cofactor binding pocket; other site 158189001203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189001204 catalytic residue [active] 158189001205 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 158189001206 active site 158189001207 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 158189001208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158189001209 active site 158189001210 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158189001211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189001212 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 158189001213 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 158189001214 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 158189001215 extended (e) SDRs; Region: SDR_e; cd08946 158189001216 NAD(P) binding site [chemical binding]; other site 158189001217 active site 158189001218 substrate binding site [chemical binding]; other site 158189001219 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 158189001220 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 158189001221 trimer interface [polypeptide binding]; other site 158189001222 active site 158189001223 substrate binding site [chemical binding]; other site 158189001224 CoA binding site [chemical binding]; other site 158189001225 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 158189001226 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 158189001227 NADP binding site [chemical binding]; other site 158189001228 active site 158189001229 putative substrate binding site [chemical binding]; other site 158189001230 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 158189001231 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 158189001232 NAD binding site [chemical binding]; other site 158189001233 substrate binding site [chemical binding]; other site 158189001234 homodimer interface [polypeptide binding]; other site 158189001235 active site 158189001236 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 158189001237 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 158189001238 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 158189001239 active site 158189001240 Substrate binding site; other site 158189001241 Mg++ binding site; other site 158189001242 galactokinase; Region: PLN02865 158189001243 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 158189001244 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 158189001245 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 158189001246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158189001247 active site 158189001248 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 158189001249 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 158189001250 substrate binding site; other site 158189001251 tetramer interface; other site 158189001252 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 158189001253 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 158189001254 NADP binding site [chemical binding]; other site 158189001255 active site 158189001256 putative substrate binding site [chemical binding]; other site 158189001257 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 158189001258 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 158189001259 NAD binding site [chemical binding]; other site 158189001260 substrate binding site [chemical binding]; other site 158189001261 homodimer interface [polypeptide binding]; other site 158189001262 active site 158189001263 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 158189001264 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158189001265 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 158189001266 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 158189001267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 158189001268 active site 158189001269 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 158189001270 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 158189001271 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 158189001272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158189001273 putative ADP-binding pocket [chemical binding]; other site 158189001274 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189001275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189001276 DNA binding site [nucleotide binding] 158189001277 domain linker motif; other site 158189001278 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189001279 dimerization interface [polypeptide binding]; other site 158189001280 ligand binding site [chemical binding]; other site 158189001281 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 158189001282 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 158189001283 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 158189001284 active site 158189001285 catalytic site [active] 158189001286 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001288 dimer interface [polypeptide binding]; other site 158189001289 conserved gate region; other site 158189001290 putative PBP binding loops; other site 158189001291 ABC-ATPase subunit interface; other site 158189001292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001293 dimer interface [polypeptide binding]; other site 158189001294 conserved gate region; other site 158189001295 putative PBP binding loops; other site 158189001296 ABC-ATPase subunit interface; other site 158189001297 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001298 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001299 Uncharacterized conserved protein [Function unknown]; Region: COG5476 158189001300 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 158189001301 MlrC C-terminus; Region: MlrC_C; pfam07171 158189001302 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 158189001303 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 158189001304 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 158189001305 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189001306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001307 dimer interface [polypeptide binding]; other site 158189001308 conserved gate region; other site 158189001309 ABC-ATPase subunit interface; other site 158189001310 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001312 dimer interface [polypeptide binding]; other site 158189001313 ABC-ATPase subunit interface; other site 158189001314 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001315 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001316 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 158189001317 Sulfatase; Region: Sulfatase; pfam00884 158189001318 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 158189001319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189001320 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158189001321 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189001322 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158189001323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189001324 Walker A/P-loop; other site 158189001325 ATP binding site [chemical binding]; other site 158189001326 Q-loop/lid; other site 158189001327 ABC transporter signature motif; other site 158189001328 Walker B; other site 158189001329 D-loop; other site 158189001330 H-loop/switch region; other site 158189001331 TOBE domain; Region: TOBE_2; pfam08402 158189001332 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158189001333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001334 dimer interface [polypeptide binding]; other site 158189001335 conserved gate region; other site 158189001336 putative PBP binding loops; other site 158189001337 ABC-ATPase subunit interface; other site 158189001338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001339 dimer interface [polypeptide binding]; other site 158189001340 conserved gate region; other site 158189001341 putative PBP binding loops; other site 158189001342 ABC-ATPase subunit interface; other site 158189001343 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 158189001344 Divergent AAA domain; Region: AAA_4; pfam04326 158189001345 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 158189001346 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189001347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189001348 non-specific DNA binding site [nucleotide binding]; other site 158189001349 salt bridge; other site 158189001350 sequence-specific DNA binding site [nucleotide binding]; other site 158189001351 Predicted amidohydrolase [General function prediction only]; Region: COG0388 158189001352 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 158189001353 putative active site [active] 158189001354 catalytic triad [active] 158189001355 putative dimer interface [polypeptide binding]; other site 158189001356 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 158189001357 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 158189001358 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 158189001359 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 158189001360 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189001361 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 158189001362 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 158189001363 zinc transporter ZupT; Provisional; Region: PRK04201 158189001364 ZIP Zinc transporter; Region: Zip; pfam02535 158189001365 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 158189001366 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158189001367 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001368 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001370 dimer interface [polypeptide binding]; other site 158189001371 conserved gate region; other site 158189001372 putative PBP binding loops; other site 158189001373 ABC-ATPase subunit interface; other site 158189001374 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001376 dimer interface [polypeptide binding]; other site 158189001377 conserved gate region; other site 158189001378 putative PBP binding loops; other site 158189001379 ABC-ATPase subunit interface; other site 158189001380 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 158189001381 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 158189001382 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189001383 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189001384 DNA binding site [nucleotide binding] 158189001385 domain linker motif; other site 158189001386 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189001387 dimerization interface [polypeptide binding]; other site 158189001388 ligand binding site [chemical binding]; other site 158189001389 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 158189001390 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 158189001391 dimerization interface [polypeptide binding]; other site 158189001392 putative active cleft [active] 158189001393 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001394 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001396 dimer interface [polypeptide binding]; other site 158189001397 conserved gate region; other site 158189001398 putative PBP binding loops; other site 158189001399 ABC-ATPase subunit interface; other site 158189001400 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001402 dimer interface [polypeptide binding]; other site 158189001403 conserved gate region; other site 158189001404 putative PBP binding loops; other site 158189001405 ABC-ATPase subunit interface; other site 158189001406 alpha-galactosidase; Provisional; Region: PRK15076 158189001407 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 158189001408 NAD binding site [chemical binding]; other site 158189001409 sugar binding site [chemical binding]; other site 158189001410 divalent metal binding site [ion binding]; other site 158189001411 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 158189001412 dimer interface [polypeptide binding]; other site 158189001413 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158189001414 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 158189001415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189001416 Phosphotransferase enzyme family; Region: APH; pfam01636 158189001417 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189001418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189001419 DNA binding site [nucleotide binding] 158189001420 domain linker motif; other site 158189001421 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189001422 ligand binding site [chemical binding]; other site 158189001423 dimerization interface [polypeptide binding]; other site 158189001424 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001425 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001426 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189001427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001428 dimer interface [polypeptide binding]; other site 158189001429 conserved gate region; other site 158189001430 putative PBP binding loops; other site 158189001431 ABC-ATPase subunit interface; other site 158189001432 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001434 dimer interface [polypeptide binding]; other site 158189001435 conserved gate region; other site 158189001436 putative PBP binding loops; other site 158189001437 ABC-ATPase subunit interface; other site 158189001438 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 158189001439 Sulfatase; Region: Sulfatase; pfam00884 158189001440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189001441 Chromate transporter; Region: Chromate_transp; pfam02417 158189001442 Chromate transporter; Region: Chromate_transp; pfam02417 158189001443 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 158189001444 AAA domain; Region: AAA_21; pfam13304 158189001445 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 158189001446 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 158189001447 active site 158189001448 putative substrate binding pocket [chemical binding]; other site 158189001449 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158189001450 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 158189001451 ligand binding site [chemical binding]; other site 158189001452 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158189001453 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189001454 Walker A/P-loop; other site 158189001455 ATP binding site [chemical binding]; other site 158189001456 Q-loop/lid; other site 158189001457 ABC transporter signature motif; other site 158189001458 Walker B; other site 158189001459 D-loop; other site 158189001460 H-loop/switch region; other site 158189001461 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189001462 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189001463 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189001464 TM-ABC transporter signature motif; other site 158189001465 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189001466 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189001467 TM-ABC transporter signature motif; other site 158189001468 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 158189001469 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 158189001470 DNA binding residues [nucleotide binding] 158189001471 drug binding residues [chemical binding]; other site 158189001472 dimer interface [polypeptide binding]; other site 158189001473 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 158189001474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 158189001475 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 158189001476 intersubunit interface [polypeptide binding]; other site 158189001477 active site 158189001478 Zn2+ binding site [ion binding]; other site 158189001479 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158189001480 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 158189001481 active site 158189001482 Cupin domain; Region: Cupin_2; cl17218 158189001483 Domain of unknown function (DUF955); Region: DUF955; cl01076 158189001484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189001485 non-specific DNA binding site [nucleotide binding]; other site 158189001486 salt bridge; other site 158189001487 sequence-specific DNA binding site [nucleotide binding]; other site 158189001488 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189001489 Zn2+ binding site [ion binding]; other site 158189001490 Mg2+ binding site [ion binding]; other site 158189001491 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 158189001492 active site 158189001493 PHP-associated; Region: PHP_C; pfam13263 158189001494 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 158189001495 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 158189001496 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 158189001497 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 158189001498 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 158189001499 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 158189001500 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 158189001501 dimer interface [polypeptide binding]; other site 158189001502 active site 158189001503 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 158189001504 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 158189001505 NAD(P) binding site [chemical binding]; other site 158189001506 homotetramer interface [polypeptide binding]; other site 158189001507 homodimer interface [polypeptide binding]; other site 158189001508 active site 158189001509 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 158189001510 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 158189001511 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 158189001512 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 158189001513 dimer interface [polypeptide binding]; other site 158189001514 active site 158189001515 CoA binding pocket [chemical binding]; other site 158189001516 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 158189001517 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 158189001518 carboxyltransferase (CT) interaction site; other site 158189001519 biotinylation site [posttranslational modification]; other site 158189001520 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 158189001521 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158189001522 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158189001523 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 158189001524 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 158189001525 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 158189001526 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 158189001527 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 158189001528 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158189001529 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158189001530 MarR family; Region: MarR; pfam01047 158189001531 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 158189001532 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 158189001533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189001534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158189001535 dimerization interface [polypeptide binding]; other site 158189001536 Histidine kinase; Region: His_kinase; pfam06580 158189001537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189001538 ATP binding site [chemical binding]; other site 158189001539 Mg2+ binding site [ion binding]; other site 158189001540 G-X-G motif; other site 158189001541 Response regulator receiver domain; Region: Response_reg; pfam00072 158189001542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189001543 active site 158189001544 phosphorylation site [posttranslational modification] 158189001545 intermolecular recognition site; other site 158189001546 dimerization interface [polypeptide binding]; other site 158189001547 Helix-turn-helix domain; Region: HTH_18; pfam12833 158189001548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189001549 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189001550 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158189001551 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189001552 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158189001553 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158189001554 DctM-like transporters; Region: DctM; pfam06808 158189001555 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189001556 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189001557 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158189001558 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158189001559 DctM-like transporters; Region: DctM; pfam06808 158189001560 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189001561 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158189001562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189001563 DNA-binding site [nucleotide binding]; DNA binding site 158189001564 FCD domain; Region: FCD; pfam07729 158189001565 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 158189001566 Ligand binding site [chemical binding]; other site 158189001567 Electron transfer flavoprotein domain; Region: ETF; pfam01012 158189001568 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 158189001569 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 158189001570 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 158189001571 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 158189001572 FAD binding domain; Region: FAD_binding_4; pfam01565 158189001573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189001574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189001575 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 158189001576 active site 158189001577 catalytic triad [active] 158189001578 oxyanion hole [active] 158189001579 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 158189001580 active site 158189001581 metal binding site [ion binding]; metal-binding site 158189001582 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 158189001583 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 158189001584 beta-D-glucuronidase; Provisional; Region: PRK10150 158189001585 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 158189001586 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189001587 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189001588 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158189001589 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 158189001590 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 158189001591 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 158189001592 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 158189001593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158189001594 dimer interface [polypeptide binding]; other site 158189001595 active site 158189001596 metal binding site [ion binding]; metal-binding site 158189001597 glutathione binding site [chemical binding]; other site 158189001598 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 158189001599 Sulfate transporter family; Region: Sulfate_transp; pfam00916 158189001600 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 158189001601 transcriptional activator RhaR; Provisional; Region: PRK13502 158189001602 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158189001603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189001604 Class I aldolases; Region: Aldolase_Class_I; cl17187 158189001605 catalytic residue [active] 158189001606 Predicted acetyltransferase [General function prediction only]; Region: COG3393 158189001607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189001608 Coenzyme A binding pocket [chemical binding]; other site 158189001609 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 158189001610 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158189001611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189001612 DNA-binding site [nucleotide binding]; DNA binding site 158189001613 FCD domain; Region: FCD; pfam07729 158189001614 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 158189001615 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 158189001616 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 158189001617 classical (c) SDRs; Region: SDR_c; cd05233 158189001618 NAD(P) binding site [chemical binding]; other site 158189001619 active site 158189001620 transketolase; Reviewed; Region: PRK05899 158189001621 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158189001622 TPP-binding site [chemical binding]; other site 158189001623 dimer interface [polypeptide binding]; other site 158189001624 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 158189001625 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158189001626 PYR/PP interface [polypeptide binding]; other site 158189001627 dimer interface [polypeptide binding]; other site 158189001628 TPP binding site [chemical binding]; other site 158189001629 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158189001630 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 158189001631 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 158189001632 Transaldolase; Region: Transaldolase; pfam00923 158189001633 catalytic residue [active] 158189001634 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 158189001635 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 158189001636 NADP binding site [chemical binding]; other site 158189001637 homodimer interface [polypeptide binding]; other site 158189001638 active site 158189001639 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001640 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001642 dimer interface [polypeptide binding]; other site 158189001643 putative PBP binding loops; other site 158189001644 ABC-ATPase subunit interface; other site 158189001645 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001647 dimer interface [polypeptide binding]; other site 158189001648 conserved gate region; other site 158189001649 putative PBP binding loops; other site 158189001650 ABC-ATPase subunit interface; other site 158189001651 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 158189001652 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 158189001653 inhibitor binding site; inhibition site 158189001654 active site 158189001655 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 158189001656 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189001657 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189001658 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158189001659 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 158189001660 active site 158189001661 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158189001662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189001663 Walker A/P-loop; other site 158189001664 ATP binding site [chemical binding]; other site 158189001665 Q-loop/lid; other site 158189001666 ABC transporter signature motif; other site 158189001667 Walker B; other site 158189001668 D-loop; other site 158189001669 H-loop/switch region; other site 158189001670 TOBE domain; Region: TOBE_2; pfam08402 158189001671 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158189001672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001673 dimer interface [polypeptide binding]; other site 158189001674 conserved gate region; other site 158189001675 putative PBP binding loops; other site 158189001676 ABC-ATPase subunit interface; other site 158189001677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001678 dimer interface [polypeptide binding]; other site 158189001679 conserved gate region; other site 158189001680 putative PBP binding loops; other site 158189001681 ABC-ATPase subunit interface; other site 158189001682 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158189001683 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189001684 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 158189001685 Domain of unknown function DUF20; Region: UPF0118; pfam01594 158189001686 Fic family protein [Function unknown]; Region: COG3177 158189001687 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 158189001688 Fic/DOC family; Region: Fic; pfam02661 158189001689 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189001690 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189001691 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158189001692 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158189001693 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 158189001694 putative NAD(P) binding site [chemical binding]; other site 158189001695 catalytic Zn binding site [ion binding]; other site 158189001696 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158189001697 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 158189001698 substrate binding site [chemical binding]; other site 158189001699 ATP binding site [chemical binding]; other site 158189001700 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 158189001701 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 158189001702 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 158189001703 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158189001704 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158189001705 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158189001706 putative active site [active] 158189001707 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189001708 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189001709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001710 dimer interface [polypeptide binding]; other site 158189001711 conserved gate region; other site 158189001712 putative PBP binding loops; other site 158189001713 ABC-ATPase subunit interface; other site 158189001714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189001715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001716 dimer interface [polypeptide binding]; other site 158189001717 conserved gate region; other site 158189001718 putative PBP binding loops; other site 158189001719 ABC-ATPase subunit interface; other site 158189001720 Protein of unknown function DUF89; Region: DUF89; cl15397 158189001721 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158189001722 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 158189001723 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 158189001724 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 158189001725 putative active site [active] 158189001726 metal binding site [ion binding]; metal-binding site 158189001727 Chromate transporter; Region: Chromate_transp; pfam02417 158189001728 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 158189001729 Chromate transporter; Region: Chromate_transp; pfam02417 158189001730 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 158189001731 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 158189001732 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 158189001733 FMN binding site [chemical binding]; other site 158189001734 substrate binding site [chemical binding]; other site 158189001735 putative catalytic residue [active] 158189001736 Purine nucleoside permease (NUP); Region: NUP; cl17832 158189001737 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189001738 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 158189001739 active site 158189001740 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189001741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189001742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 158189001743 Methyltransferase domain; Region: Methyltransf_31; pfam13847 158189001744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189001745 S-adenosylmethionine binding site [chemical binding]; other site 158189001746 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 158189001747 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 158189001748 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 158189001749 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158189001750 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158189001751 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158189001752 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189001753 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189001754 TM-ABC transporter signature motif; other site 158189001755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189001756 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189001757 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189001758 TM-ABC transporter signature motif; other site 158189001759 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158189001760 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189001761 Walker A/P-loop; other site 158189001762 ATP binding site [chemical binding]; other site 158189001763 Q-loop/lid; other site 158189001764 ABC transporter signature motif; other site 158189001765 Walker B; other site 158189001766 D-loop; other site 158189001767 H-loop/switch region; other site 158189001768 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189001769 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158189001770 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189001771 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 158189001772 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 158189001773 substrate binding site [chemical binding]; other site 158189001774 ATP binding site [chemical binding]; other site 158189001775 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 158189001776 catalytic motif [active] 158189001777 Zn binding site [ion binding]; other site 158189001778 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 158189001779 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 158189001780 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 158189001781 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 158189001782 active site 158189001783 catalytic residues [active] 158189001784 metal binding site [ion binding]; metal-binding site 158189001785 homodimer binding site [polypeptide binding]; other site 158189001786 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 158189001787 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 158189001788 carboxyltransferase (CT) interaction site; other site 158189001789 biotinylation site [posttranslational modification]; other site 158189001790 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 158189001791 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 158189001792 Walker A motif; other site 158189001793 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 158189001794 ADP-ribose binding site [chemical binding]; other site 158189001795 dimer interface [polypeptide binding]; other site 158189001796 active site 158189001797 nudix motif; other site 158189001798 metal binding site [ion binding]; metal-binding site 158189001799 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 158189001800 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 158189001801 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 158189001802 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 158189001803 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 158189001804 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 158189001805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158189001806 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158189001807 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 158189001808 active site 158189001809 trimer interface [polypeptide binding]; other site 158189001810 allosteric site; other site 158189001811 active site lid [active] 158189001812 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 158189001813 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 158189001814 dimer interface [polypeptide binding]; other site 158189001815 substrate binding site [chemical binding]; other site 158189001816 catalytic triad [active] 158189001817 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 158189001818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001819 dimer interface [polypeptide binding]; other site 158189001820 conserved gate region; other site 158189001821 putative PBP binding loops; other site 158189001822 ABC-ATPase subunit interface; other site 158189001823 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 158189001824 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 158189001825 Walker A/P-loop; other site 158189001826 ATP binding site [chemical binding]; other site 158189001827 Q-loop/lid; other site 158189001828 ABC transporter signature motif; other site 158189001829 Walker B; other site 158189001830 D-loop; other site 158189001831 H-loop/switch region; other site 158189001832 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 158189001833 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 158189001834 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 158189001835 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 158189001836 active site 158189001837 dimer interface [polypeptide binding]; other site 158189001838 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 158189001839 dimer interface [polypeptide binding]; other site 158189001840 active site 158189001841 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189001842 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189001843 DNA binding site [nucleotide binding] 158189001844 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189001845 ligand binding site [chemical binding]; other site 158189001846 dimerization interface [polypeptide binding]; other site 158189001847 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 158189001848 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 158189001849 active site 158189001850 dimer interface [polypeptide binding]; other site 158189001851 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 158189001852 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 158189001853 active site 158189001854 ADP/pyrophosphate binding site [chemical binding]; other site 158189001855 dimerization interface [polypeptide binding]; other site 158189001856 allosteric effector site; other site 158189001857 fructose-1,6-bisphosphate binding site; other site 158189001858 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 158189001859 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 158189001860 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 158189001861 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 158189001862 active site 158189001863 intersubunit interface [polypeptide binding]; other site 158189001864 zinc binding site [ion binding]; other site 158189001865 Na+ binding site [ion binding]; other site 158189001866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 158189001867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189001868 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 158189001869 Melibiase; Region: Melibiase; pfam02065 158189001870 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158189001871 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 158189001872 putative active site [active] 158189001873 putative metal binding site [ion binding]; other site 158189001874 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158189001875 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 158189001876 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 158189001877 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 158189001878 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 158189001879 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 158189001880 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 158189001881 Divergent AAA domain; Region: AAA_4; pfam04326 158189001882 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 158189001883 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 158189001884 active site 158189001885 NTP binding site [chemical binding]; other site 158189001886 metal binding triad [ion binding]; metal-binding site 158189001887 antibiotic binding site [chemical binding]; other site 158189001888 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 158189001889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001890 dimer interface [polypeptide binding]; other site 158189001891 conserved gate region; other site 158189001892 putative PBP binding loops; other site 158189001893 ABC-ATPase subunit interface; other site 158189001894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001895 dimer interface [polypeptide binding]; other site 158189001896 conserved gate region; other site 158189001897 putative PBP binding loops; other site 158189001898 ABC-ATPase subunit interface; other site 158189001899 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 158189001900 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158189001901 substrate binding pocket [chemical binding]; other site 158189001902 membrane-bound complex binding site; other site 158189001903 hinge residues; other site 158189001904 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158189001905 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158189001906 Walker A/P-loop; other site 158189001907 ATP binding site [chemical binding]; other site 158189001908 Q-loop/lid; other site 158189001909 ABC transporter signature motif; other site 158189001910 Walker B; other site 158189001911 D-loop; other site 158189001912 H-loop/switch region; other site 158189001913 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 158189001914 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 158189001915 PIN domain; Region: PIN_3; cl17397 158189001916 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 158189001917 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 158189001918 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 158189001919 putative ligand binding site [chemical binding]; other site 158189001920 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189001921 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 158189001922 TM-ABC transporter signature motif; other site 158189001923 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189001924 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 158189001925 TM-ABC transporter signature motif; other site 158189001926 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 158189001927 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 158189001928 Walker A/P-loop; other site 158189001929 ATP binding site [chemical binding]; other site 158189001930 Q-loop/lid; other site 158189001931 ABC transporter signature motif; other site 158189001932 Walker B; other site 158189001933 D-loop; other site 158189001934 H-loop/switch region; other site 158189001935 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 158189001936 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 158189001937 Walker A/P-loop; other site 158189001938 ATP binding site [chemical binding]; other site 158189001939 Q-loop/lid; other site 158189001940 ABC transporter signature motif; other site 158189001941 Walker B; other site 158189001942 D-loop; other site 158189001943 H-loop/switch region; other site 158189001944 Transposase domain (DUF772); Region: DUF772; pfam05598 158189001945 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 158189001946 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 158189001947 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 158189001948 AAA domain; Region: AAA_14; pfam13173 158189001949 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158189001950 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158189001951 ligand binding site [chemical binding]; other site 158189001952 flexible hinge region; other site 158189001953 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 158189001954 Bacterial Ig-like domain; Region: Big_5; pfam13205 158189001955 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 158189001956 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 158189001957 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 158189001958 Bacterial Ig-like domain; Region: Big_5; pfam13205 158189001959 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 158189001960 Helix-turn-helix domain; Region: HTH_17; pfam12728 158189001961 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158189001962 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158189001963 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158189001964 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 158189001965 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 158189001966 Malic enzyme, N-terminal domain; Region: malic; pfam00390 158189001967 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 158189001968 putative NAD(P) binding site [chemical binding]; other site 158189001969 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 158189001970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189001971 Coenzyme A binding pocket [chemical binding]; other site 158189001972 Predicted membrane protein [Function unknown]; Region: COG2860 158189001973 UPF0126 domain; Region: UPF0126; pfam03458 158189001974 UPF0126 domain; Region: UPF0126; pfam03458 158189001975 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 158189001976 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 158189001977 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 158189001978 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 158189001979 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 158189001980 tetramer interface [polypeptide binding]; other site 158189001981 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 158189001982 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158189001983 histidinol-phosphatase; Provisional; Region: PRK07328 158189001984 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 158189001985 active site 158189001986 dimer interface [polypeptide binding]; other site 158189001987 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 158189001988 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 158189001989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001990 dimer interface [polypeptide binding]; other site 158189001991 conserved gate region; other site 158189001992 ABC-ATPase subunit interface; other site 158189001993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189001994 dimer interface [polypeptide binding]; other site 158189001995 conserved gate region; other site 158189001996 putative PBP binding loops; other site 158189001997 ABC-ATPase subunit interface; other site 158189001998 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 158189001999 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 158189002000 Walker A/P-loop; other site 158189002001 ATP binding site [chemical binding]; other site 158189002002 Q-loop/lid; other site 158189002003 ABC transporter signature motif; other site 158189002004 Walker B; other site 158189002005 D-loop; other site 158189002006 H-loop/switch region; other site 158189002007 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 158189002008 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 158189002009 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 158189002010 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 158189002011 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158189002012 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 158189002013 switch II; other site 158189002014 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 158189002015 P loop nucleotide binding; other site 158189002016 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189002017 switch II; other site 158189002018 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 158189002019 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 158189002020 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 158189002021 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 158189002022 GDP-binding site [chemical binding]; other site 158189002023 ACT binding site; other site 158189002024 IMP binding site; other site 158189002025 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 158189002026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158189002027 active site 158189002028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158189002029 active site 158189002030 Flavin Reductases; Region: FlaRed; cl00801 158189002031 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 158189002032 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 158189002033 tetramer interface [polypeptide binding]; other site 158189002034 TPP-binding site [chemical binding]; other site 158189002035 heterodimer interface [polypeptide binding]; other site 158189002036 phosphorylation loop region [posttranslational modification] 158189002037 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 158189002038 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 158189002039 alpha subunit interface [polypeptide binding]; other site 158189002040 TPP binding site [chemical binding]; other site 158189002041 heterodimer interface [polypeptide binding]; other site 158189002042 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158189002043 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 158189002044 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 158189002045 dimer interface [polypeptide binding]; other site 158189002046 motif 1; other site 158189002047 active site 158189002048 motif 2; other site 158189002049 motif 3; other site 158189002050 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616 158189002051 tRNA synthetase B5 domain; Region: B5; smart00874 158189002052 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 158189002053 dimer interface [polypeptide binding]; other site 158189002054 motif 1; other site 158189002055 motif 3; other site 158189002056 motif 2; other site 158189002057 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 158189002058 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 158189002059 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 158189002060 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 158189002061 histidinol dehydrogenase; Region: hisD; TIGR00069 158189002062 NAD binding site [chemical binding]; other site 158189002063 dimerization interface [polypeptide binding]; other site 158189002064 product binding site; other site 158189002065 substrate binding site [chemical binding]; other site 158189002066 zinc binding site [ion binding]; other site 158189002067 catalytic residues [active] 158189002068 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 158189002069 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158189002070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189002071 homodimer interface [polypeptide binding]; other site 158189002072 catalytic residue [active] 158189002073 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 158189002074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189002075 active site 158189002076 motif I; other site 158189002077 motif II; other site 158189002078 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 158189002079 putative active site pocket [active] 158189002080 4-fold oligomerization interface [polypeptide binding]; other site 158189002081 metal binding residues [ion binding]; metal-binding site 158189002082 3-fold/trimer interface [polypeptide binding]; other site 158189002083 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 158189002084 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 158189002085 putative active site [active] 158189002086 oxyanion strand; other site 158189002087 catalytic triad [active] 158189002088 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 158189002089 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 158189002090 catalytic residues [active] 158189002091 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 158189002092 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 158189002093 substrate binding site [chemical binding]; other site 158189002094 glutamase interaction surface [polypeptide binding]; other site 158189002095 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 158189002096 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 158189002097 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 158189002098 metal binding site [ion binding]; metal-binding site 158189002099 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 158189002100 catalytic core [active] 158189002101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189002102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189002103 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158189002104 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158189002105 Walker A/P-loop; other site 158189002106 ATP binding site [chemical binding]; other site 158189002107 Q-loop/lid; other site 158189002108 ABC transporter signature motif; other site 158189002109 Walker B; other site 158189002110 D-loop; other site 158189002111 H-loop/switch region; other site 158189002112 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 158189002113 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 158189002114 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 158189002115 alpha-glucosidase; Provisional; Region: PRK10426 158189002116 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 158189002117 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 158189002118 putative active site [active] 158189002119 putative catalytic site [active] 158189002120 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 158189002121 AAA domain; Region: AAA_14; pfam13173 158189002122 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158189002123 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 158189002124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158189002125 NADH(P)-binding; Region: NAD_binding_10; pfam13460 158189002126 NAD(P) binding site [chemical binding]; other site 158189002127 active site 158189002128 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 158189002129 Putative glucoamylase; Region: Glycoamylase; pfam10091 158189002130 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 158189002131 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 158189002132 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 158189002133 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 158189002134 Carbon starvation protein CstA; Region: CstA; pfam02554 158189002135 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 158189002136 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158189002137 rod shape-determining protein MreB; Provisional; Region: PRK13930 158189002138 MreB and similar proteins; Region: MreB_like; cd10225 158189002139 nucleotide binding site [chemical binding]; other site 158189002140 Mg binding site [ion binding]; other site 158189002141 putative protofilament interaction site [polypeptide binding]; other site 158189002142 RodZ interaction site [polypeptide binding]; other site 158189002143 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 158189002144 MreB and similar proteins; Region: MreB_like; cd10225 158189002145 nucleotide binding site [chemical binding]; other site 158189002146 Mg binding site [ion binding]; other site 158189002147 putative protofilament interaction site [polypeptide binding]; other site 158189002148 RodZ interaction site [polypeptide binding]; other site 158189002149 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 158189002150 MreB and similar proteins; Region: MreB_like; cd10225 158189002151 nucleotide binding site [chemical binding]; other site 158189002152 Mg binding site [ion binding]; other site 158189002153 putative protofilament interaction site [polypeptide binding]; other site 158189002154 RodZ interaction site [polypeptide binding]; other site 158189002155 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 158189002156 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 158189002157 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 158189002158 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 158189002159 active site 158189002160 catalytic triad [active] 158189002161 oxyanion hole [active] 158189002162 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 158189002163 putative active site [active] 158189002164 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 158189002165 hypothetical protein; Reviewed; Region: PRK00024 158189002166 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 158189002167 MPN+ (JAMM) motif; other site 158189002168 Zinc-binding site [ion binding]; other site 158189002169 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 158189002170 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 158189002171 DNA binding residues [nucleotide binding] 158189002172 dimer interface [polypeptide binding]; other site 158189002173 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158189002174 DNA interaction; other site 158189002175 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158189002176 Metal-binding active site; metal-binding site 158189002177 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189002178 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158189002179 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189002180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002181 dimer interface [polypeptide binding]; other site 158189002182 conserved gate region; other site 158189002183 putative PBP binding loops; other site 158189002184 ABC-ATPase subunit interface; other site 158189002185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002186 dimer interface [polypeptide binding]; other site 158189002187 conserved gate region; other site 158189002188 putative PBP binding loops; other site 158189002189 ABC-ATPase subunit interface; other site 158189002190 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 158189002191 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158189002192 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158189002193 putative acyl-acceptor binding pocket; other site 158189002194 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158189002195 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 158189002196 active site 158189002197 catalytic site [active] 158189002198 metal binding site [ion binding]; metal-binding site 158189002199 dimer interface [polypeptide binding]; other site 158189002200 DctM-like transporters; Region: DctM; pfam06808 158189002201 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189002202 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158189002203 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189002204 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158189002205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189002206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189002207 DNA binding site [nucleotide binding] 158189002208 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189002209 ligand binding site [chemical binding]; other site 158189002210 dimerization interface [polypeptide binding]; other site 158189002211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189002212 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158189002213 Nitrogen regulatory protein P-II; Region: P-II; cl00412 158189002214 Nitrogen regulatory protein P-II; Region: P-II; smart00938 158189002215 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 158189002216 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 158189002217 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 158189002218 TPP-binding site [chemical binding]; other site 158189002219 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 158189002220 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158189002221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158189002222 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 158189002223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189002224 DNA-binding site [nucleotide binding]; DNA binding site 158189002225 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 158189002226 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158189002227 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158189002228 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158189002229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189002230 DNA-binding site [nucleotide binding]; DNA binding site 158189002231 FCD domain; Region: FCD; pfam07729 158189002232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158189002233 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189002234 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 158189002235 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 158189002236 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 158189002237 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 158189002238 ligand binding site [chemical binding]; other site 158189002239 NAD binding site [chemical binding]; other site 158189002240 dimerization interface [polypeptide binding]; other site 158189002241 catalytic site [active] 158189002242 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 158189002243 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 158189002244 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 158189002245 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158189002246 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158189002247 inhibitor site; inhibition site 158189002248 active site 158189002249 dimer interface [polypeptide binding]; other site 158189002250 catalytic residue [active] 158189002251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189002252 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189002253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002254 dimer interface [polypeptide binding]; other site 158189002255 conserved gate region; other site 158189002256 putative PBP binding loops; other site 158189002257 ABC-ATPase subunit interface; other site 158189002258 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189002259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002260 dimer interface [polypeptide binding]; other site 158189002261 conserved gate region; other site 158189002262 putative PBP binding loops; other site 158189002263 ABC-ATPase subunit interface; other site 158189002264 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 158189002265 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 158189002266 Predicted transcriptional regulator [Transcription]; Region: COG4189 158189002267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158189002268 dimerization interface [polypeptide binding]; other site 158189002269 putative DNA binding site [nucleotide binding]; other site 158189002270 putative Zn2+ binding site [ion binding]; other site 158189002271 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 158189002272 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 158189002273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 158189002274 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 158189002275 arsenical-resistance protein; Region: acr3; TIGR00832 158189002276 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 158189002277 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 158189002278 DNA binding site [nucleotide binding] 158189002279 active site 158189002280 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 158189002281 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 158189002282 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 158189002283 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 158189002284 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158189002285 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158189002286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189002287 Coenzyme A binding pocket [chemical binding]; other site 158189002288 YoaP-like; Region: YoaP; pfam14268 158189002289 Predicted transcriptional regulator [Transcription]; Region: COG2378 158189002290 HTH domain; Region: HTH_11; pfam08279 158189002291 WYL domain; Region: WYL; pfam13280 158189002292 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 158189002293 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 158189002294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158189002295 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 158189002296 active site 158189002297 metal binding site [ion binding]; metal-binding site 158189002298 Lysine efflux permease [General function prediction only]; Region: COG1279 158189002299 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189002300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189002301 DNA binding site [nucleotide binding] 158189002302 domain linker motif; other site 158189002303 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189002304 ligand binding site [chemical binding]; other site 158189002305 dimerization interface [polypeptide binding]; other site 158189002306 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189002307 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189002308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002309 dimer interface [polypeptide binding]; other site 158189002310 conserved gate region; other site 158189002311 putative PBP binding loops; other site 158189002312 ABC-ATPase subunit interface; other site 158189002313 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189002314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158189002315 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 158189002316 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 158189002317 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 158189002318 active site 158189002319 catalytic site [active] 158189002320 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189002321 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189002322 active site 158189002323 catalytic tetrad [active] 158189002324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 158189002325 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 158189002326 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189002327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002328 dimer interface [polypeptide binding]; other site 158189002329 conserved gate region; other site 158189002330 putative PBP binding loops; other site 158189002331 ABC-ATPase subunit interface; other site 158189002332 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189002333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002334 dimer interface [polypeptide binding]; other site 158189002335 conserved gate region; other site 158189002336 putative PBP binding loops; other site 158189002337 ABC-ATPase subunit interface; other site 158189002338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189002339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189002340 Helix-turn-helix domain; Region: HTH_18; pfam12833 158189002341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189002342 Helix-turn-helix domain; Region: HTH_17; pfam12728 158189002343 Fic family protein [Function unknown]; Region: COG3177 158189002344 Fic/DOC family; Region: Fic; pfam02661 158189002345 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 158189002346 AAA domain; Region: AAA_14; pfam13173 158189002347 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 158189002348 homotrimer interaction site [polypeptide binding]; other site 158189002349 zinc binding site [ion binding]; other site 158189002350 CDP-binding sites; other site 158189002351 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 158189002352 substrate binding site; other site 158189002353 dimer interface; other site 158189002354 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 158189002355 4-alpha-glucanotransferase; Provisional; Region: PRK14508 158189002356 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 158189002357 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 158189002358 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 158189002359 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 158189002360 RNA methyltransferase, RsmE family; Region: TIGR00046 158189002361 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 158189002362 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 158189002363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189002364 Radical SAM superfamily; Region: Radical_SAM; pfam04055 158189002365 FeS/SAM binding site; other site 158189002366 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 158189002367 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 158189002368 GIY-YIG motif/motif A; other site 158189002369 active site 158189002370 catalytic site [active] 158189002371 putative DNA binding site [nucleotide binding]; other site 158189002372 metal binding site [ion binding]; metal-binding site 158189002373 UvrB/uvrC motif; Region: UVR; pfam02151 158189002374 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 158189002375 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 158189002376 DNA polymerase III, delta subunit; Region: holA; TIGR01128 158189002377 LexA repressor; Validated; Region: PRK00215 158189002378 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 158189002379 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 158189002380 Catalytic site [active] 158189002381 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 158189002382 dimerization domain swap beta strand [polypeptide binding]; other site 158189002383 regulatory protein interface [polypeptide binding]; other site 158189002384 active site 158189002385 regulatory phosphorylation site [posttranslational modification]; other site 158189002386 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 158189002387 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 158189002388 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 158189002389 Hpr binding site; other site 158189002390 active site 158189002391 homohexamer subunit interaction site [polypeptide binding]; other site 158189002392 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 158189002393 30S subunit binding site; other site 158189002394 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 158189002395 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 158189002396 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 158189002397 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 158189002398 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 158189002399 Walker A/P-loop; other site 158189002400 ATP binding site [chemical binding]; other site 158189002401 Q-loop/lid; other site 158189002402 ABC transporter signature motif; other site 158189002403 Walker B; other site 158189002404 D-loop; other site 158189002405 H-loop/switch region; other site 158189002406 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 158189002407 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 158189002408 YmdB-like protein; Region: YmdB; pfam13277 158189002409 active site 158189002410 metal binding site [ion binding]; metal-binding site 158189002411 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 158189002412 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 158189002413 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 158189002414 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 158189002415 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158189002416 active site 158189002417 Uncharacterized conserved protein [Function unknown]; Region: COG1284 158189002418 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 158189002419 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 158189002420 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 158189002421 Fic/DOC family; Region: Fic; cl00960 158189002422 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 158189002423 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 158189002424 putative ligand binding site [chemical binding]; other site 158189002425 putative NAD binding site [chemical binding]; other site 158189002426 catalytic site [active] 158189002427 CpXC protein; Region: CpXC; pfam14353 158189002428 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 158189002429 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 158189002430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 158189002431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189002432 S-adenosylmethionine binding site [chemical binding]; other site 158189002433 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 158189002434 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 158189002435 dimerization interface [polypeptide binding]; other site 158189002436 domain crossover interface; other site 158189002437 redox-dependent activation switch; other site 158189002438 FtsH Extracellular; Region: FtsH_ext; pfam06480 158189002439 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 158189002440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189002441 Walker A motif; other site 158189002442 ATP binding site [chemical binding]; other site 158189002443 Walker B motif; other site 158189002444 arginine finger; other site 158189002445 Peptidase family M41; Region: Peptidase_M41; pfam01434 158189002446 pteridine reductase; Provisional; Region: PRK09135 158189002447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158189002448 NAD(P) binding site [chemical binding]; other site 158189002449 active site 158189002450 Outer membrane efflux protein; Region: OEP; pfam02321 158189002451 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 158189002452 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 158189002453 HlyD family secretion protein; Region: HlyD_3; pfam13437 158189002454 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158189002455 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158189002456 Walker A/P-loop; other site 158189002457 ATP binding site [chemical binding]; other site 158189002458 Q-loop/lid; other site 158189002459 ABC transporter signature motif; other site 158189002460 Walker B; other site 158189002461 D-loop; other site 158189002462 H-loop/switch region; other site 158189002463 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158189002464 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 158189002465 FtsX-like permease family; Region: FtsX; pfam02687 158189002466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158189002467 dimer interface [polypeptide binding]; other site 158189002468 phosphorylation site [posttranslational modification] 158189002469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189002470 ATP binding site [chemical binding]; other site 158189002471 Mg2+ binding site [ion binding]; other site 158189002472 G-X-G motif; other site 158189002473 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 158189002474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189002475 active site 158189002476 phosphorylation site [posttranslational modification] 158189002477 intermolecular recognition site; other site 158189002478 dimerization interface [polypeptide binding]; other site 158189002479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189002480 Walker A motif; other site 158189002481 ATP binding site [chemical binding]; other site 158189002482 Walker B motif; other site 158189002483 arginine finger; other site 158189002484 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 158189002485 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 158189002486 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 158189002487 active site 158189002488 Zn binding site [ion binding]; other site 158189002489 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 158189002490 TRAM domain; Region: TRAM; cl01282 158189002491 NAD synthetase; Reviewed; Region: nadE; PRK02628 158189002492 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 158189002493 multimer interface [polypeptide binding]; other site 158189002494 active site 158189002495 catalytic triad [active] 158189002496 protein interface 1 [polypeptide binding]; other site 158189002497 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 158189002498 homodimer interface [polypeptide binding]; other site 158189002499 NAD binding pocket [chemical binding]; other site 158189002500 ATP binding pocket [chemical binding]; other site 158189002501 Mg binding site [ion binding]; other site 158189002502 active-site loop [active] 158189002503 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 158189002504 putative hydrolase; Provisional; Region: PRK02113 158189002505 DNA polymerase I; Provisional; Region: PRK05755 158189002506 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 158189002507 active site 158189002508 metal binding site 1 [ion binding]; metal-binding site 158189002509 putative 5' ssDNA interaction site; other site 158189002510 metal binding site 3; metal-binding site 158189002511 metal binding site 2 [ion binding]; metal-binding site 158189002512 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 158189002513 putative DNA binding site [nucleotide binding]; other site 158189002514 putative metal binding site [ion binding]; other site 158189002515 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 158189002516 active site 158189002517 catalytic site [active] 158189002518 substrate binding site [chemical binding]; other site 158189002519 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 158189002520 active site 158189002521 DNA binding site [nucleotide binding] 158189002522 catalytic site [active] 158189002523 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 158189002524 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 158189002525 CoA-binding site [chemical binding]; other site 158189002526 ATP-binding [chemical binding]; other site 158189002527 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 158189002528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189002529 FeS/SAM binding site; other site 158189002530 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 158189002531 MFS/sugar transport protein; Region: MFS_2; pfam13347 158189002532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189002533 Predicted membrane protein [Function unknown]; Region: COG1971 158189002534 Domain of unknown function DUF; Region: DUF204; pfam02659 158189002535 Domain of unknown function DUF; Region: DUF204; pfam02659 158189002536 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 158189002537 hybrid cluster protein; Provisional; Region: PRK05290 158189002538 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158189002539 ACS interaction site; other site 158189002540 CODH interaction site; other site 158189002541 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 158189002542 hybrid metal cluster; other site 158189002543 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 158189002544 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 158189002545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189002546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189002547 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 158189002548 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189002549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002550 dimer interface [polypeptide binding]; other site 158189002551 conserved gate region; other site 158189002552 putative PBP binding loops; other site 158189002553 ABC-ATPase subunit interface; other site 158189002554 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189002555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002556 dimer interface [polypeptide binding]; other site 158189002557 conserved gate region; other site 158189002558 putative PBP binding loops; other site 158189002559 ABC-ATPase subunit interface; other site 158189002560 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189002561 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189002562 elongation factor P; Validated; Region: PRK00529 158189002563 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 158189002564 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 158189002565 RNA binding site [nucleotide binding]; other site 158189002566 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 158189002567 RNA binding site [nucleotide binding]; other site 158189002568 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 158189002569 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 158189002570 motif 1; other site 158189002571 dimer interface [polypeptide binding]; other site 158189002572 active site 158189002573 motif 2; other site 158189002574 motif 3; other site 158189002575 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 158189002576 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 158189002577 trmE is a tRNA modification GTPase; Region: trmE; cd04164 158189002578 G1 box; other site 158189002579 GTP/Mg2+ binding site [chemical binding]; other site 158189002580 Switch I region; other site 158189002581 G2 box; other site 158189002582 Switch II region; other site 158189002583 G3 box; other site 158189002584 G4 box; other site 158189002585 G5 box; other site 158189002586 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 158189002587 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 158189002588 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 158189002589 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 158189002590 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 158189002591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189002592 S-adenosylmethionine binding site [chemical binding]; other site 158189002593 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 158189002594 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 158189002595 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 158189002596 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 158189002597 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 158189002598 homodimer interface [polypeptide binding]; other site 158189002599 substrate-cofactor binding pocket; other site 158189002600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189002601 catalytic residue [active] 158189002602 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 158189002603 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158189002604 ATP binding site [chemical binding]; other site 158189002605 Mg++ binding site [ion binding]; other site 158189002606 motif III; other site 158189002607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189002608 nucleotide binding region [chemical binding]; other site 158189002609 ATP-binding site [chemical binding]; other site 158189002610 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158189002611 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158189002612 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 158189002613 Walker A/P-loop; other site 158189002614 ATP binding site [chemical binding]; other site 158189002615 Q-loop/lid; other site 158189002616 ABC transporter signature motif; other site 158189002617 Walker B; other site 158189002618 D-loop; other site 158189002619 H-loop/switch region; other site 158189002620 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158189002621 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158189002622 putative acyl-acceptor binding pocket; other site 158189002623 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158189002624 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158189002625 Walker A/P-loop; other site 158189002626 ATP binding site [chemical binding]; other site 158189002627 Q-loop/lid; other site 158189002628 ABC transporter signature motif; other site 158189002629 Walker B; other site 158189002630 D-loop; other site 158189002631 H-loop/switch region; other site 158189002632 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158189002633 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 158189002634 Walker A/P-loop; other site 158189002635 ATP binding site [chemical binding]; other site 158189002636 Q-loop/lid; other site 158189002637 ABC transporter signature motif; other site 158189002638 Walker B; other site 158189002639 D-loop; other site 158189002640 H-loop/switch region; other site 158189002641 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 158189002642 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 158189002643 GMP synthase; Reviewed; Region: guaA; PRK00074 158189002644 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 158189002645 AMP/PPi binding site [chemical binding]; other site 158189002646 candidate oxyanion hole; other site 158189002647 catalytic triad [active] 158189002648 potential glutamine specificity residues [chemical binding]; other site 158189002649 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 158189002650 ATP Binding subdomain [chemical binding]; other site 158189002651 Ligand Binding sites [chemical binding]; other site 158189002652 Dimerization subdomain; other site 158189002653 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 158189002654 active site 158189002655 metal binding site [ion binding]; metal-binding site 158189002656 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158189002657 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 158189002658 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158189002659 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 158189002660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189002661 putative substrate translocation pore; other site 158189002662 aspartate kinase; Reviewed; Region: PRK09034 158189002663 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 158189002664 nucleotide binding site [chemical binding]; other site 158189002665 substrate binding site [chemical binding]; other site 158189002666 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 158189002667 hypothetical protein; Provisional; Region: PRK04164 158189002668 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 158189002669 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 158189002670 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 158189002671 putative ligand binding site [chemical binding]; other site 158189002672 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 158189002673 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189002674 Walker A/P-loop; other site 158189002675 ATP binding site [chemical binding]; other site 158189002676 Q-loop/lid; other site 158189002677 ABC transporter signature motif; other site 158189002678 Walker B; other site 158189002679 D-loop; other site 158189002680 H-loop/switch region; other site 158189002681 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189002682 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189002683 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189002684 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189002685 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189002686 TM-ABC transporter signature motif; other site 158189002687 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 158189002688 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 158189002689 Walker A/P-loop; other site 158189002690 ATP binding site [chemical binding]; other site 158189002691 Q-loop/lid; other site 158189002692 ABC transporter signature motif; other site 158189002693 Walker B; other site 158189002694 D-loop; other site 158189002695 H-loop/switch region; other site 158189002696 TOBE domain; Region: TOBE_2; pfam08402 158189002697 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189002698 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 158189002699 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 158189002700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189002701 active site 158189002702 phosphorylation site [posttranslational modification] 158189002703 intermolecular recognition site; other site 158189002704 dimerization interface [polypeptide binding]; other site 158189002705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189002706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189002707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158189002708 dimerization interface [polypeptide binding]; other site 158189002709 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 158189002710 Histidine kinase; Region: His_kinase; pfam06580 158189002711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189002712 ATP binding site [chemical binding]; other site 158189002713 Mg2+ binding site [ion binding]; other site 158189002714 G-X-G motif; other site 158189002715 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189002716 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189002717 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189002718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002719 dimer interface [polypeptide binding]; other site 158189002720 conserved gate region; other site 158189002721 putative PBP binding loops; other site 158189002722 ABC-ATPase subunit interface; other site 158189002723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189002724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002725 dimer interface [polypeptide binding]; other site 158189002726 conserved gate region; other site 158189002727 putative PBP binding loops; other site 158189002728 ABC-ATPase subunit interface; other site 158189002729 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 158189002730 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 158189002731 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 158189002732 Uncharacterized conserved protein [Function unknown]; Region: COG3461 158189002733 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 158189002734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189002735 DNA-binding site [nucleotide binding]; DNA binding site 158189002736 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 158189002737 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 158189002738 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158189002739 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158189002740 acyl-activating enzyme (AAE) consensus motif; other site 158189002741 acyl-activating enzyme (AAE) consensus motif; other site 158189002742 AMP binding site [chemical binding]; other site 158189002743 active site 158189002744 CoA binding site [chemical binding]; other site 158189002745 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 158189002746 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 158189002747 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 158189002748 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 158189002749 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 158189002750 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 158189002751 active site 158189002752 catalytic site [active] 158189002753 substrate binding site [chemical binding]; other site 158189002754 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 158189002755 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 158189002756 active site 158189002757 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 158189002758 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 158189002759 Ligand Binding Site [chemical binding]; other site 158189002760 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158189002761 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 158189002762 active site 158189002763 trimer interface [polypeptide binding]; other site 158189002764 allosteric site; other site 158189002765 active site lid [active] 158189002766 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158189002767 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 158189002768 Uncharacterized conserved protein [Function unknown]; Region: COG2006 158189002769 4Fe-4S binding domain; Region: Fer4; cl02805 158189002770 4Fe-4S binding domain; Region: Fer4; pfam00037 158189002771 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 158189002772 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 158189002773 putative active site [active] 158189002774 catalytic site [active] 158189002775 putative metal binding site [ion binding]; other site 158189002776 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 158189002777 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 158189002778 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 158189002779 Domain of unknown function DUF20; Region: UPF0118; pfam01594 158189002780 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158189002781 endonuclease III; Region: ENDO3c; smart00478 158189002782 minor groove reading motif; other site 158189002783 helix-hairpin-helix signature motif; other site 158189002784 substrate binding pocket [chemical binding]; other site 158189002785 active site 158189002786 Protein of unknown function, DUF606; Region: DUF606; pfam04657 158189002787 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 158189002788 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 158189002789 active site pocket [active] 158189002790 putative dimer interface [polypeptide binding]; other site 158189002791 putative cataytic base [active] 158189002792 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158189002793 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158189002794 Metal-binding active site; metal-binding site 158189002795 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 158189002796 homotrimer interface [polypeptide binding]; other site 158189002797 Walker A motif; other site 158189002798 GTP binding site [chemical binding]; other site 158189002799 Walker B motif; other site 158189002800 cobalamin synthase; Reviewed; Region: cobS; PRK00235 158189002801 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 158189002802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189002803 motif II; other site 158189002804 Uncharacterized conserved protein [Function unknown]; Region: COG1912 158189002805 hypothetical protein; Provisional; Region: PRK13661 158189002806 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158189002807 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158189002808 Walker A/P-loop; other site 158189002809 ATP binding site [chemical binding]; other site 158189002810 Q-loop/lid; other site 158189002811 ABC transporter signature motif; other site 158189002812 Walker B; other site 158189002813 D-loop; other site 158189002814 H-loop/switch region; other site 158189002815 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 158189002816 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158189002817 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158189002818 Walker A/P-loop; other site 158189002819 ATP binding site [chemical binding]; other site 158189002820 Q-loop/lid; other site 158189002821 ABC transporter signature motif; other site 158189002822 Walker B; other site 158189002823 D-loop; other site 158189002824 H-loop/switch region; other site 158189002825 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 158189002826 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 158189002827 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 158189002828 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 158189002829 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 158189002830 RNA binding site [nucleotide binding]; other site 158189002831 YceG-like family; Region: YceG; pfam02618 158189002832 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 158189002833 dimerization interface [polypeptide binding]; other site 158189002834 Predicted integral membrane protein [Function unknown]; Region: COG5658 158189002835 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 158189002836 SdpI/YhfL protein family; Region: SdpI; pfam13630 158189002837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158189002838 putative DNA binding site [nucleotide binding]; other site 158189002839 dimerization interface [polypeptide binding]; other site 158189002840 putative Zn2+ binding site [ion binding]; other site 158189002841 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 158189002842 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 158189002843 active site 158189002844 nucleophile elbow; other site 158189002845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158189002846 binding surface 158189002847 TPR motif; other site 158189002848 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 158189002849 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 158189002850 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 158189002851 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 158189002852 putative active site [active] 158189002853 catalytic site [active] 158189002854 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 158189002855 putative active site [active] 158189002856 catalytic site [active] 158189002857 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158189002858 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 158189002859 substrate binding site [chemical binding]; other site 158189002860 dimer interface [polypeptide binding]; other site 158189002861 ATP binding site [chemical binding]; other site 158189002862 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158189002863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189002864 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189002865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189002866 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 158189002867 N- and C-terminal domain interface [polypeptide binding]; other site 158189002868 D-xylulose kinase; Region: XylB; TIGR01312 158189002869 active site 158189002870 MgATP binding site [chemical binding]; other site 158189002871 catalytic site [active] 158189002872 metal binding site [ion binding]; metal-binding site 158189002873 xylulose binding site [chemical binding]; other site 158189002874 putative homodimer interface [polypeptide binding]; other site 158189002875 xylose isomerase; Provisional; Region: PRK05474 158189002876 xylose isomerase; Region: xylose_isom_A; TIGR02630 158189002877 Predicted permeases [General function prediction only]; Region: COG0679 158189002878 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189002879 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189002880 active site 158189002881 catalytic tetrad [active] 158189002882 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 158189002883 diiron binding motif [ion binding]; other site 158189002884 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 158189002885 Trp repressor protein; Region: Trp_repressor; cl17266 158189002886 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 158189002887 Bacterial sugar transferase; Region: Bac_transf; pfam02397 158189002888 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 158189002889 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 158189002890 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 158189002891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158189002892 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158189002893 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 158189002894 helicase 45; Provisional; Region: PTZ00424 158189002895 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 158189002896 ATP binding site [chemical binding]; other site 158189002897 Mg++ binding site [ion binding]; other site 158189002898 motif III; other site 158189002899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189002900 nucleotide binding region [chemical binding]; other site 158189002901 ATP-binding site [chemical binding]; other site 158189002902 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 158189002903 RNA binding site [nucleotide binding]; other site 158189002904 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 158189002905 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158189002906 active site 158189002907 metal binding site [ion binding]; metal-binding site 158189002908 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 158189002909 SurA N-terminal domain; Region: SurA_N_3; cl07813 158189002910 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 158189002911 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 158189002912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189002913 motif II; other site 158189002914 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 158189002915 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158189002916 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 158189002917 ligand binding site [chemical binding]; other site 158189002918 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158189002919 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189002920 Walker A/P-loop; other site 158189002921 ATP binding site [chemical binding]; other site 158189002922 Q-loop/lid; other site 158189002923 ABC transporter signature motif; other site 158189002924 Walker B; other site 158189002925 D-loop; other site 158189002926 H-loop/switch region; other site 158189002927 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189002928 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189002929 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189002930 TM-ABC transporter signature motif; other site 158189002931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189002932 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189002933 TM-ABC transporter signature motif; other site 158189002934 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158189002935 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 158189002936 FMN binding site [chemical binding]; other site 158189002937 dimer interface [polypeptide binding]; other site 158189002938 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 158189002939 active site 158189002940 tetramer interface [polypeptide binding]; other site 158189002941 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 158189002942 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 158189002943 L-aspartate oxidase; Provisional; Region: PRK06175 158189002944 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 158189002945 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 158189002946 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 158189002947 active site 158189002948 putative substrate binding pocket [chemical binding]; other site 158189002949 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189002950 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158189002951 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158189002952 Walker A/P-loop; other site 158189002953 ATP binding site [chemical binding]; other site 158189002954 Q-loop/lid; other site 158189002955 ABC transporter signature motif; other site 158189002956 Walker B; other site 158189002957 D-loop; other site 158189002958 H-loop/switch region; other site 158189002959 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 158189002960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002961 dimer interface [polypeptide binding]; other site 158189002962 conserved gate region; other site 158189002963 putative PBP binding loops; other site 158189002964 ABC-ATPase subunit interface; other site 158189002965 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158189002966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158189002967 substrate binding pocket [chemical binding]; other site 158189002968 membrane-bound complex binding site; other site 158189002969 hinge residues; other site 158189002970 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 158189002971 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 158189002972 G1 box; other site 158189002973 GTP/Mg2+ binding site [chemical binding]; other site 158189002974 Switch I region; other site 158189002975 G2 box; other site 158189002976 G3 box; other site 158189002977 Switch II region; other site 158189002978 G4 box; other site 158189002979 G5 box; other site 158189002980 Nucleoside recognition; Region: Gate; pfam07670 158189002981 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 158189002982 Nucleoside recognition; Region: Gate; pfam07670 158189002983 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 158189002984 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 158189002985 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 158189002986 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 158189002987 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189002988 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189002989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002990 dimer interface [polypeptide binding]; other site 158189002991 conserved gate region; other site 158189002992 putative PBP binding loops; other site 158189002993 ABC-ATPase subunit interface; other site 158189002994 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189002995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189002996 dimer interface [polypeptide binding]; other site 158189002997 conserved gate region; other site 158189002998 putative PBP binding loops; other site 158189002999 ABC-ATPase subunit interface; other site 158189003000 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 158189003001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189003002 motif II; other site 158189003003 Response regulator receiver domain; Region: Response_reg; pfam00072 158189003004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189003005 active site 158189003006 phosphorylation site [posttranslational modification] 158189003007 intermolecular recognition site; other site 158189003008 dimerization interface [polypeptide binding]; other site 158189003009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189003010 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189003011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189003012 HAMP domain; Region: HAMP; pfam00672 158189003013 dimerization interface [polypeptide binding]; other site 158189003014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 158189003015 Histidine kinase; Region: His_kinase; pfam06580 158189003016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189003017 ATP binding site [chemical binding]; other site 158189003018 Mg2+ binding site [ion binding]; other site 158189003019 G-X-G motif; other site 158189003020 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 158189003021 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 158189003022 putative valine binding site [chemical binding]; other site 158189003023 dimer interface [polypeptide binding]; other site 158189003024 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 158189003025 ketol-acid reductoisomerase; Provisional; Region: PRK05479 158189003026 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 158189003027 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 158189003028 2-isopropylmalate synthase; Validated; Region: PRK00915 158189003029 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 158189003030 active site 158189003031 catalytic residues [active] 158189003032 metal binding site [ion binding]; metal-binding site 158189003033 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 158189003034 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 158189003035 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 158189003036 active site 158189003037 catalytic residues [active] 158189003038 metal binding site [ion binding]; metal-binding site 158189003039 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 158189003040 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 158189003041 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 158189003042 substrate binding site [chemical binding]; other site 158189003043 ligand binding site [chemical binding]; other site 158189003044 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 158189003045 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 158189003046 substrate binding site [chemical binding]; other site 158189003047 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 158189003048 tartrate dehydrogenase; Region: TTC; TIGR02089 158189003049 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 158189003050 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 158189003051 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 158189003052 PYR/PP interface [polypeptide binding]; other site 158189003053 dimer interface [polypeptide binding]; other site 158189003054 TPP binding site [chemical binding]; other site 158189003055 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 158189003056 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 158189003057 TPP-binding site [chemical binding]; other site 158189003058 dimer interface [polypeptide binding]; other site 158189003059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189003060 non-specific DNA binding site [nucleotide binding]; other site 158189003061 salt bridge; other site 158189003062 sequence-specific DNA binding site [nucleotide binding]; other site 158189003063 Rubrerythrin [Energy production and conversion]; Region: COG1592 158189003064 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 158189003065 iron binding site [ion binding]; other site 158189003066 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 158189003067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189003068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158189003069 putative substrate translocation pore; other site 158189003070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189003071 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 158189003072 active site 158189003073 motif I; other site 158189003074 motif II; other site 158189003075 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 158189003076 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 158189003077 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 158189003078 putative catalytic cysteine [active] 158189003079 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 158189003080 putative active site [active] 158189003081 metal binding site [ion binding]; metal-binding site 158189003082 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 158189003083 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 158189003084 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158189003085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189003086 active site 158189003087 phosphorylation site [posttranslational modification] 158189003088 intermolecular recognition site; other site 158189003089 dimerization interface [polypeptide binding]; other site 158189003090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158189003091 DNA binding site [nucleotide binding] 158189003092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158189003093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189003094 active site 158189003095 phosphorylation site [posttranslational modification] 158189003096 intermolecular recognition site; other site 158189003097 dimerization interface [polypeptide binding]; other site 158189003098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158189003099 DNA binding site [nucleotide binding] 158189003100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189003101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158189003102 dimer interface [polypeptide binding]; other site 158189003103 phosphorylation site [posttranslational modification] 158189003104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189003105 ATP binding site [chemical binding]; other site 158189003106 Mg2+ binding site [ion binding]; other site 158189003107 G-X-G motif; other site 158189003108 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 158189003109 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158189003110 active site 158189003111 metal binding site [ion binding]; metal-binding site 158189003112 homotetramer interface [polypeptide binding]; other site 158189003113 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 158189003114 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 158189003115 putative active site [active] 158189003116 putative NTP binding site [chemical binding]; other site 158189003117 putative nucleic acid binding site [nucleotide binding]; other site 158189003118 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 158189003119 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 158189003120 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158189003121 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158189003122 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158189003123 putative active site [active] 158189003124 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 158189003125 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 158189003126 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 158189003127 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158189003128 N-acetylmannosamine kinase; Provisional; Region: PRK05082 158189003129 nucleotide binding site [chemical binding]; other site 158189003130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158189003131 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189003132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189003133 dimer interface [polypeptide binding]; other site 158189003134 conserved gate region; other site 158189003135 putative PBP binding loops; other site 158189003136 ABC-ATPase subunit interface; other site 158189003137 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189003138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189003139 dimer interface [polypeptide binding]; other site 158189003140 conserved gate region; other site 158189003141 putative PBP binding loops; other site 158189003142 ABC-ATPase subunit interface; other site 158189003143 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189003144 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189003145 GTPase RsgA; Reviewed; Region: PRK01889 158189003146 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 158189003147 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 158189003148 GTPase/Zn-binding domain interface [polypeptide binding]; other site 158189003149 GTP/Mg2+ binding site [chemical binding]; other site 158189003150 G4 box; other site 158189003151 G5 box; other site 158189003152 G1 box; other site 158189003153 Switch I region; other site 158189003154 G2 box; other site 158189003155 G3 box; other site 158189003156 Switch II region; other site 158189003157 RNHCP domain; Region: RNHCP; pfam12647 158189003158 Short C-terminal domain; Region: SHOCT; pfam09851 158189003159 Short C-terminal domain; Region: SHOCT; pfam09851 158189003160 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 158189003161 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158189003162 metal-binding site [ion binding] 158189003163 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158189003164 Soluble P-type ATPase [General function prediction only]; Region: COG4087 158189003165 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158189003166 metal-binding site [ion binding] 158189003167 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 158189003168 putative homodimer interface [polypeptide binding]; other site 158189003169 putative homotetramer interface [polypeptide binding]; other site 158189003170 putative allosteric switch controlling residues; other site 158189003171 putative metal binding site [ion binding]; other site 158189003172 putative homodimer-homodimer interface [polypeptide binding]; other site 158189003173 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 158189003174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158189003175 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 158189003176 Condensation domain; Region: Condensation; pfam00668 158189003177 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 158189003178 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 158189003179 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 158189003180 ApbE family; Region: ApbE; pfam02424 158189003181 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 158189003182 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 158189003183 catalytic residue [active] 158189003184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189003185 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 158189003186 Na binding site [ion binding]; other site 158189003187 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158189003188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189003189 active site 158189003190 phosphorylation site [posttranslational modification] 158189003191 intermolecular recognition site; other site 158189003192 dimerization interface [polypeptide binding]; other site 158189003193 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158189003194 DNA binding residues [nucleotide binding] 158189003195 dimerization interface [polypeptide binding]; other site 158189003196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 158189003197 Histidine kinase; Region: HisKA_3; pfam07730 158189003198 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 158189003199 ATP binding site [chemical binding]; other site 158189003200 Mg2+ binding site [ion binding]; other site 158189003201 G-X-G motif; other site 158189003202 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189003203 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158189003204 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189003205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189003206 dimer interface [polypeptide binding]; other site 158189003207 putative PBP binding loops; other site 158189003208 ABC-ATPase subunit interface; other site 158189003209 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189003210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189003211 dimer interface [polypeptide binding]; other site 158189003212 conserved gate region; other site 158189003213 putative PBP binding loops; other site 158189003214 ABC-ATPase subunit interface; other site 158189003215 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 158189003216 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 158189003217 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 158189003218 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 158189003219 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 158189003220 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 158189003221 catalytic residues [active] 158189003222 dimer interface [polypeptide binding]; other site 158189003223 Fic/DOC family; Region: Fic; pfam02661 158189003224 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 158189003225 catalytic residues [active] 158189003226 dimer interface [polypeptide binding]; other site 158189003227 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 158189003228 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 158189003229 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 158189003230 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 158189003231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158189003232 Coenzyme A binding pocket [chemical binding]; other site 158189003233 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189003234 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189003235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189003236 ABC-ATPase subunit interface; other site 158189003237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189003238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189003239 dimer interface [polypeptide binding]; other site 158189003240 ABC-ATPase subunit interface; other site 158189003241 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189003242 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189003243 DNA binding site [nucleotide binding] 158189003244 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 158189003245 dimerization interface [polypeptide binding]; other site 158189003246 ligand binding site [chemical binding]; other site 158189003247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189003248 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158189003249 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158189003250 ligand binding site [chemical binding]; other site 158189003251 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189003252 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189003253 Walker A/P-loop; other site 158189003254 ATP binding site [chemical binding]; other site 158189003255 Q-loop/lid; other site 158189003256 ABC transporter signature motif; other site 158189003257 Walker B; other site 158189003258 D-loop; other site 158189003259 H-loop/switch region; other site 158189003260 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189003261 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189003262 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189003263 TM-ABC transporter signature motif; other site 158189003264 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189003265 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189003266 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158189003267 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158189003268 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 158189003269 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 158189003270 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 158189003271 homodimer interface [polypeptide binding]; other site 158189003272 substrate-cofactor binding pocket; other site 158189003273 catalytic residue [active] 158189003274 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 158189003275 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158189003276 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189003277 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189003278 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189003279 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 158189003280 EamA-like transporter family; Region: EamA; pfam00892 158189003281 EamA-like transporter family; Region: EamA; pfam00892 158189003282 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 158189003283 Protein export membrane protein; Region: SecD_SecF; cl14618 158189003284 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 158189003285 carboxyltransferase (CT) interaction site; other site 158189003286 biotinylation site [posttranslational modification]; other site 158189003287 HlyD family secretion protein; Region: HlyD_3; pfam13437 158189003288 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 158189003289 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 158189003290 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 158189003291 putative active site [active] 158189003292 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158189003293 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 158189003294 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158189003295 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158189003296 Metal-binding active site; metal-binding site 158189003297 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158189003298 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189003299 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158189003300 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 158189003301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189003302 Walker A/P-loop; other site 158189003303 ATP binding site [chemical binding]; other site 158189003304 Q-loop/lid; other site 158189003305 ABC transporter signature motif; other site 158189003306 Walker B; other site 158189003307 D-loop; other site 158189003308 H-loop/switch region; other site 158189003309 TOBE domain; Region: TOBE_2; pfam08402 158189003310 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158189003311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189003312 dimer interface [polypeptide binding]; other site 158189003313 conserved gate region; other site 158189003314 putative PBP binding loops; other site 158189003315 ABC-ATPase subunit interface; other site 158189003316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189003317 dimer interface [polypeptide binding]; other site 158189003318 conserved gate region; other site 158189003319 ABC-ATPase subunit interface; other site 158189003320 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 158189003321 dimerization interface [polypeptide binding]; other site 158189003322 putative active cleft [active] 158189003323 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 158189003324 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 158189003325 active site 158189003326 substrate binding site [chemical binding]; other site 158189003327 metal binding site [ion binding]; metal-binding site 158189003328 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158189003329 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 158189003330 active site 158189003331 trimer interface [polypeptide binding]; other site 158189003332 allosteric site; other site 158189003333 active site lid [active] 158189003334 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158189003335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189003336 PAS domain; Region: PAS_9; pfam13426 158189003337 putative active site [active] 158189003338 heme pocket [chemical binding]; other site 158189003339 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158189003340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158189003341 binding surface 158189003342 TPR motif; other site 158189003343 Tetratricopeptide repeat; Region: TPR_12; pfam13424 158189003344 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 158189003345 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 158189003346 active site 158189003347 8-oxo-dGMP binding site [chemical binding]; other site 158189003348 nudix motif; other site 158189003349 metal binding site [ion binding]; metal-binding site 158189003350 monoglyceride lipase; Provisional; Region: PHA02857 158189003351 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158189003352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 158189003353 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 158189003354 LPP20 lipoprotein; Region: LPP20; pfam02169 158189003355 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 158189003356 catalytic site [active] 158189003357 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158189003358 active site residue [active] 158189003359 PAS domain; Region: PAS_9; pfam13426 158189003360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189003361 PAS domain; Region: PAS_9; pfam13426 158189003362 putative active site [active] 158189003363 heme pocket [chemical binding]; other site 158189003364 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189003365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189003366 metal binding site [ion binding]; metal-binding site 158189003367 active site 158189003368 I-site; other site 158189003369 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189003370 Zn2+ binding site [ion binding]; other site 158189003371 Mg2+ binding site [ion binding]; other site 158189003372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189003373 metal binding site [ion binding]; metal-binding site 158189003374 active site 158189003375 I-site; other site 158189003376 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158189003377 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158189003378 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189003379 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189003380 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189003381 active site 158189003382 catalytic tetrad [active] 158189003383 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 158189003384 catalytic residues [active] 158189003385 dimer interface [polypeptide binding]; other site 158189003386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158189003387 MarR family; Region: MarR; pfam01047 158189003388 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 158189003389 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 158189003390 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 158189003391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189003392 FeS/SAM binding site; other site 158189003393 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 158189003394 Pyruvate formate lyase 1; Region: PFL1; cd01678 158189003395 coenzyme A binding site [chemical binding]; other site 158189003396 active site 158189003397 catalytic residues [active] 158189003398 glycine loop; other site 158189003399 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158189003400 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158189003401 ligand binding site [chemical binding]; other site 158189003402 flexible hinge region; other site 158189003403 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 158189003404 putative switch regulator; other site 158189003405 non-specific DNA interactions [nucleotide binding]; other site 158189003406 DNA binding site [nucleotide binding] 158189003407 sequence specific DNA binding site [nucleotide binding]; other site 158189003408 putative cAMP binding site [chemical binding]; other site 158189003409 Predicted permease; Region: DUF318; cl17795 158189003410 Predicted permease; Region: DUF318; cl17795 158189003411 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 158189003412 FOG: CBS domain [General function prediction only]; Region: COG0517 158189003413 Uncharacterized conserved protein [Function unknown]; Region: COG2461 158189003414 Family of unknown function (DUF438); Region: DUF438; pfam04282 158189003415 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 158189003416 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 158189003417 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 158189003418 substrate binding pocket [chemical binding]; other site 158189003419 chain length determination region; other site 158189003420 substrate-Mg2+ binding site; other site 158189003421 catalytic residues [active] 158189003422 aspartate-rich region 1; other site 158189003423 active site lid residues [active] 158189003424 aspartate-rich region 2; other site 158189003425 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 158189003426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189003427 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 158189003428 LysE type translocator; Region: LysE; cl00565 158189003429 oligoendopeptidase F; Region: pepF; TIGR00181 158189003430 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 158189003431 active site 158189003432 Zn binding site [ion binding]; other site 158189003433 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 158189003434 active site 158189003435 dimerization interface [polypeptide binding]; other site 158189003436 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 158189003437 DHH family; Region: DHH; pfam01368 158189003438 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 158189003439 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 158189003440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189003441 Walker A motif; other site 158189003442 ATP binding site [chemical binding]; other site 158189003443 Walker B motif; other site 158189003444 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 158189003445 Clp protease; Region: CLP_protease; pfam00574 158189003446 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 158189003447 oligomer interface [polypeptide binding]; other site 158189003448 active site residues [active] 158189003449 trigger factor; Provisional; Region: tig; PRK01490 158189003450 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 158189003451 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 158189003452 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 158189003453 ArsC family; Region: ArsC; pfam03960 158189003454 putative ArsC-like catalytic residues; other site 158189003455 putative TRX-like catalytic residues [active] 158189003456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 158189003457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189003458 Coenzyme A binding pocket [chemical binding]; other site 158189003459 putative pectinesterase; Region: PLN02432; cl01911 158189003460 Predicted membrane protein [Function unknown]; Region: COG2855 158189003461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 158189003462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 158189003463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 158189003464 dimerization interface [polypeptide binding]; other site 158189003465 Fic family protein [Function unknown]; Region: COG3177 158189003466 Fic/DOC family; Region: Fic; pfam02661 158189003467 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 158189003468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189003469 Walker A motif; other site 158189003470 ATP binding site [chemical binding]; other site 158189003471 Walker B motif; other site 158189003472 arginine finger; other site 158189003473 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 158189003474 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158189003475 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 158189003476 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 158189003477 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 158189003478 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 158189003479 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 158189003480 active site 158189003481 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 158189003482 PHP-associated; Region: PHP_C; pfam13263 158189003483 DRTGG domain; Region: DRTGG; pfam07085 158189003484 FOG: CBS domain [General function prediction only]; Region: COG0517 158189003485 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 158189003486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 158189003487 ATP binding site [chemical binding]; other site 158189003488 G-X-G motif; other site 158189003489 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158189003490 active site 158189003491 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 158189003492 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 158189003493 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 158189003494 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 158189003495 Nitrogen regulatory protein P-II; Region: P-II; smart00938 158189003496 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 158189003497 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 158189003498 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 158189003499 putative active site [active] 158189003500 putative substrate binding site [chemical binding]; other site 158189003501 putative cosubstrate binding site; other site 158189003502 catalytic site [active] 158189003503 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 158189003504 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 158189003505 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 158189003506 generic binding surface I; other site 158189003507 generic binding surface II; other site 158189003508 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189003509 4Fe-4S binding domain; Region: Fer4; cl02805 158189003510 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189003511 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189003512 metal binding site [ion binding]; metal-binding site 158189003513 active site 158189003514 I-site; other site 158189003515 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 158189003516 DNA topoisomerase III; Provisional; Region: PRK07726 158189003517 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 158189003518 active site 158189003519 putative interdomain interaction site [polypeptide binding]; other site 158189003520 putative metal-binding site [ion binding]; other site 158189003521 putative nucleotide binding site [chemical binding]; other site 158189003522 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 158189003523 domain I; other site 158189003524 DNA binding groove [nucleotide binding] 158189003525 phosphate binding site [ion binding]; other site 158189003526 domain II; other site 158189003527 domain III; other site 158189003528 nucleotide binding site [chemical binding]; other site 158189003529 catalytic site [active] 158189003530 domain IV; other site 158189003531 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 158189003532 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 158189003533 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 158189003534 DctM-like transporters; Region: DctM; pfam06808 158189003535 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 158189003536 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 158189003537 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 158189003538 hydroxyglutarate oxidase; Provisional; Region: PRK11728 158189003539 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 158189003540 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 158189003541 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 158189003542 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158189003543 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189003544 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 158189003545 4Fe-4S binding domain; Region: Fer4; pfam00037 158189003546 dihydrodipicolinate reductase; Provisional; Region: PRK00048 158189003547 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 158189003548 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 158189003549 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 158189003550 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 158189003551 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 158189003552 dihydrodipicolinate synthase; Region: dapA; TIGR00674 158189003553 dimer interface [polypeptide binding]; other site 158189003554 active site 158189003555 catalytic residue [active] 158189003556 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 158189003557 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158189003558 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 158189003559 dihydrodipicolinate reductase; Provisional; Region: PRK00048 158189003560 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 158189003561 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 158189003562 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 158189003563 dihydrodipicolinate synthase; Region: dapA; TIGR00674 158189003564 dimer interface [polypeptide binding]; other site 158189003565 active site 158189003566 catalytic residue [active] 158189003567 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 158189003568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158189003569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189003570 homodimer interface [polypeptide binding]; other site 158189003571 catalytic residue [active] 158189003572 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 158189003573 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 158189003574 active site 158189003575 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158189003576 substrate binding site [chemical binding]; other site 158189003577 catalytic residues [active] 158189003578 dimer interface [polypeptide binding]; other site 158189003579 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 158189003580 active site 158189003581 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 158189003582 putative ligand binding site [chemical binding]; other site 158189003583 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 158189003584 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 158189003585 putative ATP binding site [chemical binding]; other site 158189003586 putative substrate interface [chemical binding]; other site 158189003587 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189003588 active site 158189003589 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 158189003590 AzlC protein; Region: AzlC; cl00570 158189003591 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 158189003592 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 158189003593 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 158189003594 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 158189003595 FMN-binding domain; Region: FMN_bind; cl01081 158189003596 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158189003597 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158189003598 active site 158189003599 metal binding site [ion binding]; metal-binding site 158189003600 YhhN-like protein; Region: YhhN; pfam07947 158189003601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189003602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189003603 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 158189003604 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 158189003605 V-type ATP synthase subunit I; Validated; Region: PRK05771 158189003606 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 158189003607 Archaeal/vacuolar-type H+-ATPase subunit F [Energy production and conversion]; Region: NtpG; COG1436 158189003608 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 158189003609 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 158189003610 V-type ATP synthase subunit A; Provisional; Region: PRK04192 158189003611 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158189003612 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 158189003613 Walker A motif/ATP binding site; other site 158189003614 Walker B motif; other site 158189003615 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 158189003616 V-type ATP synthase subunit B; Provisional; Region: PRK04196 158189003617 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158189003618 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 158189003619 Walker A motif homologous position; other site 158189003620 Walker B motif; other site 158189003621 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 158189003622 ATP synthase subunit D; Region: ATP-synt_D; cl00613 158189003623 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 158189003624 Ligand Binding Site [chemical binding]; other site 158189003625 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158189003626 active site 158189003627 phosphorylation site [posttranslational modification] 158189003628 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 158189003629 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 158189003630 dimer interface [polypeptide binding]; other site 158189003631 active site 158189003632 metal binding site [ion binding]; metal-binding site 158189003633 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 158189003634 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 158189003635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158189003636 Beta-Casp domain; Region: Beta-Casp; smart01027 158189003637 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 158189003638 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158189003639 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158189003640 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158189003641 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189003642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189003643 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189003644 Walker A/P-loop; other site 158189003645 ATP binding site [chemical binding]; other site 158189003646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158189003647 dimerization interface [polypeptide binding]; other site 158189003648 putative DNA binding site [nucleotide binding]; other site 158189003649 putative Zn2+ binding site [ion binding]; other site 158189003650 Predicted permeases [General function prediction only]; Region: COG0701 158189003651 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 158189003652 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 158189003653 Low molecular weight phosphatase family; Region: LMWPc; cd00115 158189003654 active site 158189003655 EamA-like transporter family; Region: EamA; pfam00892 158189003656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189003657 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158189003658 putative substrate translocation pore; other site 158189003659 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 158189003660 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 158189003661 G1 box; other site 158189003662 putative GEF interaction site [polypeptide binding]; other site 158189003663 GTP/Mg2+ binding site [chemical binding]; other site 158189003664 Switch I region; other site 158189003665 G2 box; other site 158189003666 G3 box; other site 158189003667 Switch II region; other site 158189003668 G4 box; other site 158189003669 G5 box; other site 158189003670 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 158189003671 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 158189003672 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 158189003673 active site 158189003674 putative catalytic site [active] 158189003675 DNA binding site [nucleotide binding] 158189003676 putative phosphate binding site [ion binding]; other site 158189003677 metal binding site A [ion binding]; metal-binding site 158189003678 AP binding site [nucleotide binding]; other site 158189003679 metal binding site B [ion binding]; metal-binding site 158189003680 asparagine synthetase AsnA; Provisional; Region: PRK05425 158189003681 motif 1; other site 158189003682 dimer interface [polypeptide binding]; other site 158189003683 active site 158189003684 motif 2; other site 158189003685 motif 3; other site 158189003686 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 158189003687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189003688 motif II; other site 158189003689 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 158189003690 beta-galactosidase; Region: BGL; TIGR03356 158189003691 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 158189003692 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 158189003693 P-loop; other site 158189003694 Magnesium ion binding site [ion binding]; other site 158189003695 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 158189003696 Magnesium ion binding site [ion binding]; other site 158189003697 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 158189003698 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 158189003699 active site 158189003700 catalytic site [active] 158189003701 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 158189003702 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 158189003703 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 158189003704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189003705 Walker A/P-loop; other site 158189003706 ATP binding site [chemical binding]; other site 158189003707 Q-loop/lid; other site 158189003708 ABC transporter signature motif; other site 158189003709 Walker B; other site 158189003710 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 158189003711 Part of AAA domain; Region: AAA_19; pfam13245 158189003712 Family description; Region: UvrD_C_2; pfam13538 158189003713 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 158189003714 Uncharacterized conserved protein [Function unknown]; Region: COG2006 158189003715 Domain of unknown function (DUF362); Region: DUF362; pfam04015 158189003716 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 158189003717 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 158189003718 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 158189003719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189003720 S-adenosylmethionine binding site [chemical binding]; other site 158189003721 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 158189003722 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 158189003723 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 158189003724 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158189003725 catalytic residues [active] 158189003726 Haemolysin-III related; Region: HlyIII; cl03831 158189003727 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 158189003728 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158189003729 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158189003730 Walker A/P-loop; other site 158189003731 ATP binding site [chemical binding]; other site 158189003732 Q-loop/lid; other site 158189003733 ABC transporter signature motif; other site 158189003734 Walker B; other site 158189003735 D-loop; other site 158189003736 H-loop/switch region; other site 158189003737 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 158189003738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189003739 dimer interface [polypeptide binding]; other site 158189003740 conserved gate region; other site 158189003741 putative PBP binding loops; other site 158189003742 ABC-ATPase subunit interface; other site 158189003743 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158189003744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158189003745 substrate binding pocket [chemical binding]; other site 158189003746 membrane-bound complex binding site; other site 158189003747 hinge residues; other site 158189003748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158189003749 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158189003750 substrate binding pocket [chemical binding]; other site 158189003751 membrane-bound complex binding site; other site 158189003752 hinge residues; other site 158189003753 Divergent PAP2 family; Region: DUF212; pfam02681 158189003754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189003755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158189003756 putative substrate translocation pore; other site 158189003757 aconitate hydratase; Validated; Region: PRK07229 158189003758 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 158189003759 substrate binding site [chemical binding]; other site 158189003760 ligand binding site [chemical binding]; other site 158189003761 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 158189003762 substrate binding site [chemical binding]; other site 158189003763 isocitrate dehydrogenase; Validated; Region: PRK07362 158189003764 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 158189003765 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 158189003766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189003767 motif II; other site 158189003768 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 158189003769 dimer interface [polypeptide binding]; other site 158189003770 Citrate synthase; Region: Citrate_synt; pfam00285 158189003771 active site 158189003772 citrylCoA binding site [chemical binding]; other site 158189003773 NADH binding [chemical binding]; other site 158189003774 cationic pore residues; other site 158189003775 oxalacetate/citrate binding site [chemical binding]; other site 158189003776 coenzyme A binding site [chemical binding]; other site 158189003777 catalytic triad [active] 158189003778 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158189003779 dimerization interface [polypeptide binding]; other site 158189003780 putative DNA binding site [nucleotide binding]; other site 158189003781 putative Zn2+ binding site [ion binding]; other site 158189003782 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 158189003783 nucleoside/Zn binding site; other site 158189003784 dimer interface [polypeptide binding]; other site 158189003785 catalytic motif [active] 158189003786 argininosuccinate synthase; Provisional; Region: PRK13820 158189003787 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 158189003788 ANP binding site [chemical binding]; other site 158189003789 Substrate Binding Site II [chemical binding]; other site 158189003790 Substrate Binding Site I [chemical binding]; other site 158189003791 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 158189003792 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158189003793 Walker A/P-loop; other site 158189003794 ATP binding site [chemical binding]; other site 158189003795 Q-loop/lid; other site 158189003796 ABC transporter signature motif; other site 158189003797 Walker B; other site 158189003798 D-loop; other site 158189003799 H-loop/switch region; other site 158189003800 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 158189003801 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 158189003802 HflC protein; Region: hflC; TIGR01932 158189003803 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 158189003804 HflK protein; Region: hflK; TIGR01933 158189003805 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 158189003806 probable methionyl-tRNA synthetase; Region: PLN02610 158189003807 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 158189003808 active site 158189003809 HIGH motif; other site 158189003810 KMSKS motif; other site 158189003811 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 158189003812 tRNA binding surface [nucleotide binding]; other site 158189003813 anticodon binding site; other site 158189003814 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 158189003815 putative tRNA-binding site [nucleotide binding]; other site 158189003816 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 158189003817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 158189003818 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 158189003819 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158189003820 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 158189003821 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158189003822 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158189003823 dimer interface [polypeptide binding]; other site 158189003824 ssDNA binding site [nucleotide binding]; other site 158189003825 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158189003826 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 158189003827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 158189003828 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 158189003829 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 158189003830 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 158189003831 replicative DNA helicase; Region: DnaB; TIGR00665 158189003832 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 158189003833 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 158189003834 Walker A motif; other site 158189003835 ATP binding site [chemical binding]; other site 158189003836 Walker B motif; other site 158189003837 DNA binding loops [nucleotide binding] 158189003838 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 158189003839 active site 158189003840 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 158189003841 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 158189003842 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 158189003843 putative substrate binding region [chemical binding]; other site 158189003844 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 158189003845 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 158189003846 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 158189003847 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 158189003848 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 158189003849 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 158189003850 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 158189003851 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 158189003852 catalytic residue [active] 158189003853 putative FPP diphosphate binding site; other site 158189003854 putative FPP binding hydrophobic cleft; other site 158189003855 dimer interface [polypeptide binding]; other site 158189003856 putative IPP diphosphate binding site; other site 158189003857 ribosome recycling factor; Reviewed; Region: frr; PRK00083 158189003858 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 158189003859 hinge region; other site 158189003860 elongation factor Ts; Provisional; Region: tsf; PRK09377 158189003861 UBA/TS-N domain; Region: UBA; pfam00627 158189003862 Elongation factor TS; Region: EF_TS; pfam00889 158189003863 Elongation factor TS; Region: EF_TS; pfam00889 158189003864 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 158189003865 rRNA interaction site [nucleotide binding]; other site 158189003866 S8 interaction site; other site 158189003867 putative laminin-1 binding site; other site 158189003868 DctM-like transporters; Region: DctM; pfam06808 158189003869 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189003870 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158189003871 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189003872 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158189003873 Maf-like protein; Region: Maf; pfam02545 158189003874 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 158189003875 active site 158189003876 dimer interface [polypeptide binding]; other site 158189003877 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158189003878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189003879 Walker A/P-loop; other site 158189003880 ATP binding site [chemical binding]; other site 158189003881 Q-loop/lid; other site 158189003882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189003883 ABC transporter signature motif; other site 158189003884 Walker B; other site 158189003885 D-loop; other site 158189003886 ABC transporter; Region: ABC_tran_2; pfam12848 158189003887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189003888 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520 158189003889 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 158189003890 active site 158189003891 catalytic residue [active] 158189003892 dimer interface [polypeptide binding]; other site 158189003893 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 158189003894 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 158189003895 shikimate binding site; other site 158189003896 NAD(P) binding site [chemical binding]; other site 158189003897 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 158189003898 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 158189003899 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158189003900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189003901 ATP binding site [chemical binding]; other site 158189003902 putative Mg++ binding site [ion binding]; other site 158189003903 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 158189003904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189003905 nucleotide binding region [chemical binding]; other site 158189003906 ATP-binding site [chemical binding]; other site 158189003907 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 158189003908 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 158189003909 Tetramer interface [polypeptide binding]; other site 158189003910 active site 158189003911 FMN-binding site [chemical binding]; other site 158189003912 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 158189003913 active site 158189003914 shikimate kinase; Reviewed; Region: aroK; PRK00131 158189003915 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 158189003916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189003917 Zn2+ binding site [ion binding]; other site 158189003918 Mg2+ binding site [ion binding]; other site 158189003919 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 158189003920 ATP cone domain; Region: ATP-cone; pfam03477 158189003921 Family description; Region: ACT_7; pfam13840 158189003922 NTPase; Region: NTPase_1; cl17478 158189003923 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 158189003924 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 158189003925 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 158189003926 active site 158189003927 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 158189003928 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 158189003929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189003930 ATP binding site [chemical binding]; other site 158189003931 putative Mg++ binding site [ion binding]; other site 158189003932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189003933 nucleotide binding region [chemical binding]; other site 158189003934 ATP-binding site [chemical binding]; other site 158189003935 TRCF domain; Region: TRCF; pfam03461 158189003936 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 158189003937 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 158189003938 elongation factor G; Reviewed; Region: PRK12740 158189003939 G1 box; other site 158189003940 putative GEF interaction site [polypeptide binding]; other site 158189003941 GTP/Mg2+ binding site [chemical binding]; other site 158189003942 Switch I region; other site 158189003943 G2 box; other site 158189003944 G3 box; other site 158189003945 Switch II region; other site 158189003946 G4 box; other site 158189003947 G5 box; other site 158189003948 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 158189003949 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 158189003950 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 158189003951 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189003952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189003953 non-specific DNA binding site [nucleotide binding]; other site 158189003954 salt bridge; other site 158189003955 sequence-specific DNA binding site [nucleotide binding]; other site 158189003956 elongation factor G; Reviewed; Region: PRK00007 158189003957 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 158189003958 G1 box; other site 158189003959 putative GEF interaction site [polypeptide binding]; other site 158189003960 GTP/Mg2+ binding site [chemical binding]; other site 158189003961 Switch I region; other site 158189003962 G2 box; other site 158189003963 G3 box; other site 158189003964 Switch II region; other site 158189003965 G4 box; other site 158189003966 G5 box; other site 158189003967 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 158189003968 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 158189003969 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 158189003970 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 158189003971 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158189003972 metal-binding site [ion binding] 158189003973 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158189003974 Soluble P-type ATPase [General function prediction only]; Region: COG4087 158189003975 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 158189003976 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 158189003977 Cl- selectivity filter; other site 158189003978 Cl- binding residues [ion binding]; other site 158189003979 pore gating glutamate residue; other site 158189003980 dimer interface [polypeptide binding]; other site 158189003981 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 158189003982 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 158189003983 intersubunit interface [polypeptide binding]; other site 158189003984 active site 158189003985 Zn2+ binding site [ion binding]; other site 158189003986 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 158189003987 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158189003988 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158189003989 substrate binding site [chemical binding]; other site 158189003990 trimer interface [polypeptide binding]; other site 158189003991 Mn binding site [ion binding]; other site 158189003992 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 158189003993 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 158189003994 NAD(P) binding site [chemical binding]; other site 158189003995 catalytic residues [active] 158189003996 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 158189003997 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 158189003998 oligomer interface [polypeptide binding]; other site 158189003999 active site 158189004000 metal binding site [ion binding]; metal-binding site 158189004001 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 158189004002 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 158189004003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189004004 Walker A motif; other site 158189004005 ATP binding site [chemical binding]; other site 158189004006 Walker B motif; other site 158189004007 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 158189004008 putative efflux protein, MATE family; Region: matE; TIGR00797 158189004009 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 158189004010 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158189004011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189004012 catalytic residue [active] 158189004013 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 158189004014 ATP-NAD kinase; Region: NAD_kinase; pfam01513 158189004015 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 158189004016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189004017 Walker A/P-loop; other site 158189004018 ATP binding site [chemical binding]; other site 158189004019 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 158189004020 ABC transporter signature motif; other site 158189004021 Walker B; other site 158189004022 D-loop; other site 158189004023 H-loop/switch region; other site 158189004024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189004025 Coenzyme A binding pocket [chemical binding]; other site 158189004026 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 158189004027 active site 158189004028 catalytic site [active] 158189004029 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 158189004030 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158189004031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 158189004032 Uncharacterized conserved protein [Function unknown]; Region: COG1543 158189004033 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 158189004034 active site 158189004035 substrate binding site [chemical binding]; other site 158189004036 catalytic site [active] 158189004037 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 158189004038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 158189004039 MraZ protein; Region: MraZ; pfam02381 158189004040 MraZ protein; Region: MraZ; pfam02381 158189004041 MraW methylase family; Region: Methyltransf_5; cl17771 158189004042 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 158189004043 Cell division protein FtsL; Region: FtsL; cl11433 158189004044 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 158189004045 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 158189004046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158189004047 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 158189004048 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 158189004049 Mg++ binding site [ion binding]; other site 158189004050 putative catalytic motif [active] 158189004051 cell division protein FtsW; Region: ftsW; TIGR02614 158189004052 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 158189004053 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 158189004054 Cell division protein FtsA; Region: FtsA; smart00842 158189004055 Cell division protein FtsA; Region: FtsA; pfam14450 158189004056 cell division protein FtsZ; Validated; Region: PRK09330 158189004057 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 158189004058 nucleotide binding site [chemical binding]; other site 158189004059 SulA interaction site; other site 158189004060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158189004061 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 158189004062 active site 158189004063 DNA binding site [nucleotide binding] 158189004064 Int/Topo IB signature motif; other site 158189004065 hypothetical protein; Provisional; Region: PRK10621 158189004066 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 158189004067 DNA protecting protein DprA; Region: dprA; TIGR00732 158189004068 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158189004069 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 158189004070 active site 158189004071 DNA binding site [nucleotide binding] 158189004072 Int/Topo IB signature motif; other site 158189004073 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 158189004074 active site 158189004075 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 158189004076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189004077 Walker A motif; other site 158189004078 ATP binding site [chemical binding]; other site 158189004079 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 158189004080 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 158189004081 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158189004082 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 158189004083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 158189004084 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 158189004085 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 158189004086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158189004087 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 158189004088 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158189004089 Peptidase family M23; Region: Peptidase_M23; pfam01551 158189004090 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 158189004091 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 158189004092 SEC-C motif; Region: SEC-C; pfam02810 158189004093 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 158189004094 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 158189004095 active site 158189004096 homodimer interface [polypeptide binding]; other site 158189004097 Colicin V production protein; Region: Colicin_V; pfam02674 158189004098 DNA polymerase III subunit delta'; Validated; Region: PRK08485 158189004099 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 158189004100 PAS domain; Region: PAS; smart00091 158189004101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158189004102 dimer interface [polypeptide binding]; other site 158189004103 phosphorylation site [posttranslational modification] 158189004104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189004105 ATP binding site [chemical binding]; other site 158189004106 Mg2+ binding site [ion binding]; other site 158189004107 G-X-G motif; other site 158189004108 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 158189004109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189004110 active site 158189004111 phosphorylation site [posttranslational modification] 158189004112 intermolecular recognition site; other site 158189004113 dimerization interface [polypeptide binding]; other site 158189004114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189004115 Walker A motif; other site 158189004116 ATP binding site [chemical binding]; other site 158189004117 Walker B motif; other site 158189004118 arginine finger; other site 158189004119 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 158189004120 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 158189004121 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 158189004122 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 158189004123 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 158189004124 oligomerisation interface [polypeptide binding]; other site 158189004125 mobile loop; other site 158189004126 roof hairpin; other site 158189004127 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 158189004128 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 158189004129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 158189004130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158189004131 DNA binding residues [nucleotide binding] 158189004132 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158189004133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189004134 DNA-binding site [nucleotide binding]; DNA binding site 158189004135 FCD domain; Region: FCD; pfam07729 158189004136 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 158189004137 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 158189004138 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 158189004139 NADP binding site [chemical binding]; other site 158189004140 homodimer interface [polypeptide binding]; other site 158189004141 active site 158189004142 pyruvate phosphate dikinase; Provisional; Region: PRK09279 158189004143 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 158189004144 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 158189004145 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 158189004146 UGMP family protein; Validated; Region: PRK09604 158189004147 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 158189004148 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 158189004149 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158189004150 active site 158189004151 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 158189004152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189004153 Walker A/P-loop; other site 158189004154 ATP binding site [chemical binding]; other site 158189004155 Q-loop/lid; other site 158189004156 ABC transporter signature motif; other site 158189004157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189004158 Walker B; other site 158189004159 D-loop; other site 158189004160 H-loop/switch region; other site 158189004161 ABC transporter; Region: ABC_tran_2; pfam12848 158189004162 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189004163 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158189004164 nucleotide binding site [chemical binding]; other site 158189004165 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 158189004166 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 158189004167 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 158189004168 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 158189004169 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 158189004170 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 158189004171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158189004172 Coenzyme A binding pocket [chemical binding]; other site 158189004173 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 158189004174 RNA/DNA hybrid binding site [nucleotide binding]; other site 158189004175 active site 158189004176 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 158189004177 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 158189004178 Walker A/P-loop; other site 158189004179 ATP binding site [chemical binding]; other site 158189004180 Q-loop/lid; other site 158189004181 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 158189004182 Q-loop/lid; other site 158189004183 ABC transporter signature motif; other site 158189004184 Walker B; other site 158189004185 D-loop; other site 158189004186 H-loop/switch region; other site 158189004187 signal recognition particle protein; Provisional; Region: PRK10867 158189004188 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 158189004189 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 158189004190 P loop; other site 158189004191 GTP binding site [chemical binding]; other site 158189004192 Signal peptide binding domain; Region: SRP_SPB; pfam02978 158189004193 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 158189004194 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 158189004195 hypothetical protein; Provisional; Region: PRK00468 158189004196 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 158189004197 RimM N-terminal domain; Region: RimM; pfam01782 158189004198 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 158189004199 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 158189004200 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 158189004201 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 158189004202 active site 158189004203 (T/H)XGH motif; other site 158189004204 ribosomal protein L32; Region: rpmF_bact; TIGR01031 158189004205 acyl carrier protein; Provisional; Region: acpP; PRK00982 158189004206 ribonuclease III; Reviewed; Region: rnc; PRK00102 158189004207 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 158189004208 dimerization interface [polypeptide binding]; other site 158189004209 active site 158189004210 metal binding site [ion binding]; metal-binding site 158189004211 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 158189004212 dsRNA binding site [nucleotide binding]; other site 158189004213 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 158189004214 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 158189004215 active site 158189004216 NTP binding site [chemical binding]; other site 158189004217 metal binding triad [ion binding]; metal-binding site 158189004218 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 158189004219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189004220 Zn2+ binding site [ion binding]; other site 158189004221 Mg2+ binding site [ion binding]; other site 158189004222 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 158189004223 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 158189004224 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 158189004225 HIGH motif; other site 158189004226 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 158189004227 active site 158189004228 KMSKS motif; other site 158189004229 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 158189004230 tRNA binding surface [nucleotide binding]; other site 158189004231 anticodon binding site; other site 158189004232 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 158189004233 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 158189004234 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 158189004235 active site 158189004236 HIGH motif; other site 158189004237 dimer interface [polypeptide binding]; other site 158189004238 KMSKS motif; other site 158189004239 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189004240 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158189004241 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189004242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189004243 dimer interface [polypeptide binding]; other site 158189004244 conserved gate region; other site 158189004245 putative PBP binding loops; other site 158189004246 ABC-ATPase subunit interface; other site 158189004247 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189004248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189004249 dimer interface [polypeptide binding]; other site 158189004250 conserved gate region; other site 158189004251 putative PBP binding loops; other site 158189004252 ABC-ATPase subunit interface; other site 158189004253 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 158189004254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189004255 Walker A/P-loop; other site 158189004256 ATP binding site [chemical binding]; other site 158189004257 Q-loop/lid; other site 158189004258 ABC transporter signature motif; other site 158189004259 Walker B; other site 158189004260 D-loop; other site 158189004261 H-loop/switch region; other site 158189004262 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 158189004263 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 158189004264 active site 158189004265 substrate binding site [chemical binding]; other site 158189004266 metal binding site [ion binding]; metal-binding site 158189004267 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 158189004268 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 158189004269 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 158189004270 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 158189004271 active site 158189004272 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 158189004273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 158189004274 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 158189004275 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 158189004276 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 158189004277 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 158189004278 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 158189004279 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 158189004280 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 158189004281 Ligand Binding Site [chemical binding]; other site 158189004282 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 158189004283 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 158189004284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189004285 catalytic residue [active] 158189004286 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 158189004287 active site 158189004288 dimer interface [polypeptide binding]; other site 158189004289 metal binding site [ion binding]; metal-binding site 158189004290 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158189004291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189004292 ATP binding site [chemical binding]; other site 158189004293 putative Mg++ binding site [ion binding]; other site 158189004294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189004295 nucleotide binding region [chemical binding]; other site 158189004296 ATP-binding site [chemical binding]; other site 158189004297 Helicase associated domain (HA2); Region: HA2; pfam04408 158189004298 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 158189004299 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 158189004300 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 158189004301 dimer interface [polypeptide binding]; other site 158189004302 motif 1; other site 158189004303 active site 158189004304 motif 2; other site 158189004305 motif 3; other site 158189004306 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 158189004307 anticodon binding site; other site 158189004308 poly(A) polymerase; Region: pcnB; TIGR01942 158189004309 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 158189004310 active site 158189004311 NTP binding site [chemical binding]; other site 158189004312 metal binding triad [ion binding]; metal-binding site 158189004313 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 158189004314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158189004315 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158189004316 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 158189004317 SLBB domain; Region: SLBB; pfam10531 158189004318 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 158189004319 FMN-binding domain; Region: FMN_bind; cl01081 158189004320 electron transport complex RsxE subunit; Provisional; Region: PRK12405 158189004321 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 158189004322 ferredoxin; Validated; Region: PRK07118 158189004323 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 158189004324 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 158189004325 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 158189004326 peptide chain release factor 2; Validated; Region: prfB; PRK00578 158189004327 This domain is found in peptide chain release factors; Region: PCRF; smart00937 158189004328 RF-1 domain; Region: RF-1; pfam00472 158189004329 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 158189004330 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 158189004331 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158189004332 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158189004333 FtsX-like permease family; Region: FtsX; pfam02687 158189004334 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158189004335 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158189004336 Walker A/P-loop; other site 158189004337 ATP binding site [chemical binding]; other site 158189004338 Q-loop/lid; other site 158189004339 ABC transporter signature motif; other site 158189004340 Walker B; other site 158189004341 D-loop; other site 158189004342 H-loop/switch region; other site 158189004343 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158189004344 FtsX-like permease family; Region: FtsX; pfam02687 158189004345 ribonuclease Z; Region: RNase_Z; TIGR02651 158189004346 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 158189004347 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 158189004348 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 158189004349 Thiamine pyrophosphokinase; Region: TPK; cd07995 158189004350 active site 158189004351 dimerization interface [polypeptide binding]; other site 158189004352 thiamine binding site [chemical binding]; other site 158189004353 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cl10037 158189004354 homotrimer interaction site [polypeptide binding]; other site 158189004355 active site 158189004356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158189004357 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158189004358 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 158189004359 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 158189004360 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 158189004361 hinge; other site 158189004362 active site 158189004363 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189004364 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189004365 DNA binding site [nucleotide binding] 158189004366 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189004367 dimerization interface [polypeptide binding]; other site 158189004368 ligand binding site [chemical binding]; other site 158189004369 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 158189004370 DNA primase; Validated; Region: dnaG; PRK05667 158189004371 CHC2 zinc finger; Region: zf-CHC2; pfam01807 158189004372 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 158189004373 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 158189004374 active site 158189004375 metal binding site [ion binding]; metal-binding site 158189004376 interdomain interaction site; other site 158189004377 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 158189004378 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 158189004379 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 158189004380 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 158189004381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 158189004382 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 158189004383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158189004384 DNA binding residues [nucleotide binding] 158189004385 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 158189004386 Putative zinc ribbon domain; Region: DUF164; pfam02591 158189004387 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 158189004388 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 158189004389 B12 binding site [chemical binding]; other site 158189004390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189004391 FeS/SAM binding site; other site 158189004392 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 158189004393 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 158189004394 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 158189004395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189004396 DNA-binding site [nucleotide binding]; DNA binding site 158189004397 TrkA-C domain; Region: TrkA_C; pfam02080 158189004398 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 158189004399 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 158189004400 homodimer interface [polypeptide binding]; other site 158189004401 metal binding site [ion binding]; metal-binding site 158189004402 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 158189004403 homodimer interface [polypeptide binding]; other site 158189004404 active site 158189004405 putative chemical substrate binding site [chemical binding]; other site 158189004406 metal binding site [ion binding]; metal-binding site 158189004407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189004408 DNA-binding site [nucleotide binding]; DNA binding site 158189004409 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158189004410 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158189004411 Walker A/P-loop; other site 158189004412 ATP binding site [chemical binding]; other site 158189004413 Q-loop/lid; other site 158189004414 ABC transporter signature motif; other site 158189004415 Walker B; other site 158189004416 D-loop; other site 158189004417 H-loop/switch region; other site 158189004418 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 158189004419 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 158189004420 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 158189004421 glutaminase active site [active] 158189004422 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 158189004423 dimer interface [polypeptide binding]; other site 158189004424 active site 158189004425 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 158189004426 dimer interface [polypeptide binding]; other site 158189004427 active site 158189004428 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 158189004429 Tetratricopeptide repeat; Region: TPR_6; pfam13174 158189004430 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 158189004431 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 158189004432 RNA binding site [nucleotide binding]; other site 158189004433 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 158189004434 RNA binding site [nucleotide binding]; other site 158189004435 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 158189004436 RNA binding site [nucleotide binding]; other site 158189004437 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 158189004438 RNA binding site [nucleotide binding]; other site 158189004439 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 158189004440 RNA binding site [nucleotide binding]; other site 158189004441 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 158189004442 RNA binding site [nucleotide binding]; other site 158189004443 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 158189004444 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 158189004445 CMP-binding site; other site 158189004446 The sites determining sugar specificity; other site 158189004447 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 158189004448 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158189004449 RNA binding surface [nucleotide binding]; other site 158189004450 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 158189004451 active site 158189004452 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 158189004453 ScpA/B protein; Region: ScpA_ScpB; cl00598 158189004454 recombinase A; Provisional; Region: recA; PRK09354 158189004455 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 158189004456 hexamer interface [polypeptide binding]; other site 158189004457 Walker A motif; other site 158189004458 ATP binding site [chemical binding]; other site 158189004459 Walker B motif; other site 158189004460 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 158189004461 putative active site [active] 158189004462 dimerization interface [polypeptide binding]; other site 158189004463 putative tRNAtyr binding site [nucleotide binding]; other site 158189004464 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 158189004465 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 158189004466 substrate binding site [chemical binding]; other site 158189004467 hexamer interface [polypeptide binding]; other site 158189004468 metal binding site [ion binding]; metal-binding site 158189004469 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 158189004470 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 158189004471 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 158189004472 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 158189004473 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 158189004474 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 158189004475 integral membrane protein MviN; Region: mviN; TIGR01695 158189004476 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 158189004477 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 158189004478 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 158189004479 Predicted permeases [General function prediction only]; Region: COG0795 158189004480 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 158189004481 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 158189004482 Predicted permeases [General function prediction only]; Region: COG0795 158189004483 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 158189004484 trimer interface [polypeptide binding]; other site 158189004485 active site 158189004486 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 158189004487 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 158189004488 RNase E interface [polypeptide binding]; other site 158189004489 trimer interface [polypeptide binding]; other site 158189004490 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 158189004491 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 158189004492 RNase E interface [polypeptide binding]; other site 158189004493 trimer interface [polypeptide binding]; other site 158189004494 active site 158189004495 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 158189004496 putative nucleic acid binding region [nucleotide binding]; other site 158189004497 G-X-X-G motif; other site 158189004498 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 158189004499 RNA binding site [nucleotide binding]; other site 158189004500 domain interface; other site 158189004501 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 158189004502 16S/18S rRNA binding site [nucleotide binding]; other site 158189004503 S13e-L30e interaction site [polypeptide binding]; other site 158189004504 25S rRNA binding site [nucleotide binding]; other site 158189004505 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 158189004506 active site 158189004507 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 158189004508 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 158189004509 RNA binding site [nucleotide binding]; other site 158189004510 active site 158189004511 Ribosome-binding factor A; Region: RBFA; pfam02033 158189004512 translation initiation factor IF-2; Region: IF-2; TIGR00487 158189004513 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 158189004514 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 158189004515 G1 box; other site 158189004516 putative GEF interaction site [polypeptide binding]; other site 158189004517 GTP/Mg2+ binding site [chemical binding]; other site 158189004518 Switch I region; other site 158189004519 G2 box; other site 158189004520 G3 box; other site 158189004521 Switch II region; other site 158189004522 G4 box; other site 158189004523 G5 box; other site 158189004524 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 158189004525 Translation-initiation factor 2; Region: IF-2; pfam11987 158189004526 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 158189004527 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 158189004528 NusA N-terminal domain; Region: NusA_N; pfam08529 158189004529 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 158189004530 RNA binding site [nucleotide binding]; other site 158189004531 homodimer interface [polypeptide binding]; other site 158189004532 NusA-like KH domain; Region: KH_5; pfam13184 158189004533 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 158189004534 G-X-X-G motif; other site 158189004535 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 158189004536 Double zinc ribbon; Region: DZR; pfam12773 158189004537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 158189004538 Sm and related proteins; Region: Sm_like; cl00259 158189004539 comF family protein; Region: comF; TIGR00201 158189004540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 158189004541 active site 158189004542 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 158189004543 MutS domain I; Region: MutS_I; pfam01624 158189004544 MutS domain II; Region: MutS_II; pfam05188 158189004545 MutS domain III; Region: MutS_III; pfam05192 158189004546 MutS domain V; Region: MutS_V; pfam00488 158189004547 Walker A/P-loop; other site 158189004548 ATP binding site [chemical binding]; other site 158189004549 Q-loop/lid; other site 158189004550 ABC transporter signature motif; other site 158189004551 Walker B; other site 158189004552 D-loop; other site 158189004553 H-loop/switch region; other site 158189004554 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 158189004555 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 158189004556 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 158189004557 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 158189004558 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 158189004559 Surface antigen; Region: Bac_surface_Ag; pfam01103 158189004560 Family of unknown function (DUF490); Region: DUF490; pfam04357 158189004561 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 158189004562 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 158189004563 TMP-binding site; other site 158189004564 ATP-binding site [chemical binding]; other site 158189004565 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 158189004566 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 158189004567 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 158189004568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189004569 Walker A motif; other site 158189004570 ATP binding site [chemical binding]; other site 158189004571 Walker B motif; other site 158189004572 arginine finger; other site 158189004573 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 158189004574 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 158189004575 RuvA N terminal domain; Region: RuvA_N; pfam01330 158189004576 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 158189004577 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 158189004578 active site 158189004579 putative DNA-binding cleft [nucleotide binding]; other site 158189004580 dimer interface [polypeptide binding]; other site 158189004581 hypothetical protein; Validated; Region: PRK00110 158189004582 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 158189004583 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189004584 FeS/SAM binding site; other site 158189004585 HemN C-terminal domain; Region: HemN_C; pfam06969 158189004586 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 158189004587 Catalytic site [active] 158189004588 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 158189004589 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 158189004590 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 158189004591 SmpB-tmRNA interface; other site 158189004592 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 158189004593 active site 158189004594 catalytic residues [active] 158189004595 DNA binding site [nucleotide binding] 158189004596 Int/Topo IB signature motif; other site 158189004597 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 158189004598 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 158189004599 transmembrane helices; other site 158189004600 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 158189004601 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158189004602 active site 158189004603 metal binding site [ion binding]; metal-binding site 158189004604 homotetramer interface [polypeptide binding]; other site 158189004605 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 158189004606 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 158189004607 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 158189004608 NAD-dependent deacetylase; Provisional; Region: PRK00481 158189004609 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 158189004610 NAD+ binding site [chemical binding]; other site 158189004611 substrate binding site [chemical binding]; other site 158189004612 Zn binding site [ion binding]; other site 158189004613 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14335 158189004614 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 158189004615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189004616 FeS/SAM binding site; other site 158189004617 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 158189004618 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 158189004619 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 158189004620 homodimer interface [polypeptide binding]; other site 158189004621 NADP binding site [chemical binding]; other site 158189004622 substrate binding site [chemical binding]; other site 158189004623 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 158189004624 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158189004625 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158189004626 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 158189004627 active site 158189004628 catalytic site [active] 158189004629 metal binding site [ion binding]; metal-binding site 158189004630 dimer interface [polypeptide binding]; other site 158189004631 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189004632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189004633 dimer interface [polypeptide binding]; other site 158189004634 conserved gate region; other site 158189004635 putative PBP binding loops; other site 158189004636 ABC-ATPase subunit interface; other site 158189004637 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 158189004638 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 158189004639 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189004640 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158189004641 Protein of unknown function, DUF624; Region: DUF624; pfam04854 158189004642 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 158189004643 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158189004644 active site 158189004645 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 158189004646 active site 158189004647 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 158189004648 putative RNA binding site [nucleotide binding]; other site 158189004649 SurA N-terminal domain; Region: SurA_N_3; cl07813 158189004650 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 158189004651 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158189004652 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 158189004653 triosephosphate isomerase; Provisional; Region: PRK14567 158189004654 substrate binding site [chemical binding]; other site 158189004655 dimer interface [polypeptide binding]; other site 158189004656 catalytic triad [active] 158189004657 Phosphoglycerate kinase; Region: PGK; pfam00162 158189004658 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 158189004659 substrate binding site [chemical binding]; other site 158189004660 hinge regions; other site 158189004661 ADP binding site [chemical binding]; other site 158189004662 catalytic site [active] 158189004663 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 158189004664 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 158189004665 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 158189004666 FOG: CBS domain [General function prediction only]; Region: COG0517 158189004667 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 158189004668 Transporter associated domain; Region: CorC_HlyC; smart01091 158189004669 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 158189004670 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 158189004671 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 158189004672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189004673 Zn2+ binding site [ion binding]; other site 158189004674 Mg2+ binding site [ion binding]; other site 158189004675 PhoH-like protein; Region: PhoH; pfam02562 158189004676 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 158189004677 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 158189004678 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 158189004679 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 158189004680 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 158189004681 GcpE protein; Region: GcpE; pfam04551 158189004682 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 158189004683 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 158189004684 Domain of unknown function (DUF386); Region: DUF386; cl01047 158189004685 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 158189004686 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 158189004687 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 158189004688 DNA binding site [nucleotide binding] 158189004689 active site 158189004690 V-type ATP synthase subunit K; Validated; Region: PRK06649 158189004691 V-type ATP synthase subunit I; Validated; Region: PRK05771 158189004692 V-type ATP synthase subunit D; Provisional; Region: PRK02195 158189004693 V-type ATP synthase subunit B; Provisional; Region: PRK02118 158189004694 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158189004695 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 158189004696 Walker A motif homologous position; other site 158189004697 Walker B motif; other site 158189004698 V-type ATP synthase subunit A; Provisional; Region: PRK04192 158189004699 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158189004700 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 158189004701 Walker A motif/ATP binding site; other site 158189004702 Walker B motif; other site 158189004703 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 158189004704 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 158189004705 V-type ATP synthase subunit E; Provisional; Region: PRK01558 158189004706 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 158189004707 GIY-YIG motif/motif A; other site 158189004708 active site 158189004709 catalytic site [active] 158189004710 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 158189004711 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158189004712 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 158189004713 GIY-YIG motif/motif A; other site 158189004714 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 158189004715 MutS domain III; Region: MutS_III; pfam05192 158189004716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189004717 Walker A/P-loop; other site 158189004718 ATP binding site [chemical binding]; other site 158189004719 Q-loop/lid; other site 158189004720 ABC transporter signature motif; other site 158189004721 Walker B; other site 158189004722 D-loop; other site 158189004723 H-loop/switch region; other site 158189004724 Smr domain; Region: Smr; pfam01713 158189004725 GTPase RsgA; Reviewed; Region: PRK00098 158189004726 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 158189004727 RNA binding site [nucleotide binding]; other site 158189004728 homodimer interface [polypeptide binding]; other site 158189004729 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 158189004730 GTPase/Zn-binding domain interface [polypeptide binding]; other site 158189004731 GTP/Mg2+ binding site [chemical binding]; other site 158189004732 G4 box; other site 158189004733 G5 box; other site 158189004734 G1 box; other site 158189004735 Switch I region; other site 158189004736 G2 box; other site 158189004737 G3 box; other site 158189004738 Switch II region; other site 158189004739 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 158189004740 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 158189004741 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 158189004742 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 158189004743 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158189004744 RNA binding surface [nucleotide binding]; other site 158189004745 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158189004746 active site 158189004747 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 158189004748 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158189004749 catalytic residue [active] 158189004750 Predicted membrane protein [Function unknown]; Region: COG4905 158189004751 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 158189004752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189004753 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 158189004754 putative active site [active] 158189004755 heme pocket [chemical binding]; other site 158189004756 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189004757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189004758 metal binding site [ion binding]; metal-binding site 158189004759 active site 158189004760 I-site; other site 158189004761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189004762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189004763 metal binding site [ion binding]; metal-binding site 158189004764 active site 158189004765 I-site; other site 158189004766 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158189004767 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 158189004768 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158189004769 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 158189004770 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 158189004771 active site 158189004772 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 158189004773 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 158189004774 active site 158189004775 homodimer interface [polypeptide binding]; other site 158189004776 catalytic site [active] 158189004777 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189004778 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189004779 DNA binding site [nucleotide binding] 158189004780 domain linker motif; other site 158189004781 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189004782 adenylate kinase; Reviewed; Region: adk; PRK00279 158189004783 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 158189004784 AMP-binding site [chemical binding]; other site 158189004785 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 158189004786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158189004787 active site 158189004788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158189004789 binding surface 158189004790 TPR motif; other site 158189004791 Chromate transporter; Region: Chromate_transp; pfam02417 158189004792 Chromate transporter; Region: Chromate_transp; pfam02417 158189004793 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 158189004794 RNA/DNA hybrid binding site [nucleotide binding]; other site 158189004795 active site 158189004796 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 158189004797 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 158189004798 putative binding site residues; other site 158189004799 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 158189004800 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158189004801 ABC-ATPase subunit interface; other site 158189004802 dimer interface [polypeptide binding]; other site 158189004803 putative PBP binding regions; other site 158189004804 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158189004805 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 158189004806 Walker A/P-loop; other site 158189004807 ATP binding site [chemical binding]; other site 158189004808 Q-loop/lid; other site 158189004809 ABC transporter signature motif; other site 158189004810 Walker B; other site 158189004811 D-loop; other site 158189004812 H-loop/switch region; other site 158189004813 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158189004814 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158189004815 putative acyl-acceptor binding pocket; other site 158189004816 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189004817 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189004818 Domain of unknown function (DUF336); Region: DUF336; cl01249 158189004819 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 158189004820 putative active site; other site 158189004821 putative metal binding residues [ion binding]; other site 158189004822 signature motif; other site 158189004823 putative triphosphate binding site [ion binding]; other site 158189004824 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 158189004825 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 158189004826 cofactor binding site; other site 158189004827 DNA binding site [nucleotide binding] 158189004828 substrate interaction site [chemical binding]; other site 158189004829 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 158189004830 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 158189004831 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 158189004832 DNA binding site [nucleotide binding] 158189004833 substrate interaction site [chemical binding]; other site 158189004834 AIPR protein; Region: AIPR; pfam10592 158189004835 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 158189004836 Z1 domain; Region: Z1; pfam10593 158189004837 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 158189004838 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 158189004839 2'-5' RNA ligase; Provisional; Region: PRK15124 158189004840 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 158189004841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189004842 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 158189004843 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158189004844 agmatinase; Region: agmatinase; TIGR01230 158189004845 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 158189004846 putative active site [active] 158189004847 Mn binding site [ion binding]; other site 158189004848 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 158189004849 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 158189004850 dimer interface [polypeptide binding]; other site 158189004851 active site 158189004852 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158189004853 catalytic residues [active] 158189004854 substrate binding site [chemical binding]; other site 158189004855 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 158189004856 arginine decarboxylase; Provisional; Region: PRK05354 158189004857 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 158189004858 dimer interface [polypeptide binding]; other site 158189004859 active site 158189004860 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158189004861 catalytic residues [active] 158189004862 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 158189004863 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 158189004864 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 158189004865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 158189004866 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 158189004867 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 158189004868 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158189004869 active site 158189004870 metal binding site [ion binding]; metal-binding site 158189004871 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 158189004872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 158189004873 hypothetical protein; Provisional; Region: PRK10281 158189004874 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 158189004875 putative active site [active] 158189004876 metal binding site [ion binding]; metal-binding site 158189004877 Protein of unknown function DUF72; Region: DUF72; pfam01904 158189004878 4-alpha-glucanotransferase; Provisional; Region: PRK14508 158189004879 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189004880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189004881 dimer interface [polypeptide binding]; other site 158189004882 conserved gate region; other site 158189004883 putative PBP binding loops; other site 158189004884 ABC-ATPase subunit interface; other site 158189004885 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189004886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189004887 dimer interface [polypeptide binding]; other site 158189004888 conserved gate region; other site 158189004889 putative PBP binding loops; other site 158189004890 ABC-ATPase subunit interface; other site 158189004891 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189004892 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189004893 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189004894 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189004895 metal binding site [ion binding]; metal-binding site 158189004896 active site 158189004897 I-site; other site 158189004898 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189004899 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189004900 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189004901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189004902 dimer interface [polypeptide binding]; other site 158189004903 conserved gate region; other site 158189004904 putative PBP binding loops; other site 158189004905 ABC-ATPase subunit interface; other site 158189004906 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189004907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189004908 dimer interface [polypeptide binding]; other site 158189004909 conserved gate region; other site 158189004910 putative PBP binding loops; other site 158189004911 ABC-ATPase subunit interface; other site 158189004912 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158189004913 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158189004914 substrate binding pocket [chemical binding]; other site 158189004915 membrane-bound complex binding site; other site 158189004916 hinge residues; other site 158189004917 PAS domain S-box; Region: sensory_box; TIGR00229 158189004918 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189004919 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189004920 metal binding site [ion binding]; metal-binding site 158189004921 active site 158189004922 I-site; other site 158189004923 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 158189004924 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189004925 Zn2+ binding site [ion binding]; other site 158189004926 Mg2+ binding site [ion binding]; other site 158189004927 PAS domain S-box; Region: sensory_box; TIGR00229 158189004928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189004929 putative active site [active] 158189004930 heme pocket [chemical binding]; other site 158189004931 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 158189004932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 158189004933 putative active site [active] 158189004934 heme pocket [chemical binding]; other site 158189004935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189004936 putative active site [active] 158189004937 heme pocket [chemical binding]; other site 158189004938 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 158189004939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189004940 active site 158189004941 motif I; other site 158189004942 motif II; other site 158189004943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 158189004944 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 158189004945 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 158189004946 tetramer interface [polypeptide binding]; other site 158189004947 heme binding pocket [chemical binding]; other site 158189004948 NADPH binding site [chemical binding]; other site 158189004949 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189004950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189004951 metal binding site [ion binding]; metal-binding site 158189004952 active site 158189004953 I-site; other site 158189004954 Protein of unknown function DUF72; Region: DUF72; pfam01904 158189004955 DNA polymerase IV; Validated; Region: PRK01810 158189004956 Y-family of DNA polymerases; Region: PolY; cl12025 158189004957 active site 158189004958 DNA binding site [nucleotide binding] 158189004959 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 158189004960 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 158189004961 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 158189004962 active site 158189004963 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 158189004964 generic binding surface I; other site 158189004965 generic binding surface II; other site 158189004966 photolyase PhrII; Region: phr2; TIGR00591 158189004967 DNA photolyase; Region: DNA_photolyase; pfam00875 158189004968 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 158189004969 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158189004970 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 158189004971 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158189004972 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 158189004973 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 158189004974 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 158189004975 nudix motif; other site 158189004976 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189004977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189004978 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158189004979 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158189004980 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158189004981 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158189004982 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 158189004983 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 158189004984 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158189004985 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189004986 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158189004987 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189004988 Walker A/P-loop; other site 158189004989 ATP binding site [chemical binding]; other site 158189004990 Q-loop/lid; other site 158189004991 ABC transporter signature motif; other site 158189004992 Walker B; other site 158189004993 D-loop; other site 158189004994 H-loop/switch region; other site 158189004995 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189004996 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189004997 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189004998 TM-ABC transporter signature motif; other site 158189004999 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189005000 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189005001 TM-ABC transporter signature motif; other site 158189005002 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 158189005003 Active site serine [active] 158189005004 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 158189005005 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158189005006 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158189005007 active site 158189005008 metal binding site [ion binding]; metal-binding site 158189005009 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 158189005010 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 158189005011 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 158189005012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158189005013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189005014 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158189005015 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 158189005016 active site residue [active] 158189005017 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158189005018 active site residue [active] 158189005019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189005020 Walker A motif; other site 158189005021 ATP binding site [chemical binding]; other site 158189005022 Walker B motif; other site 158189005023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 158189005024 Integrase core domain; Region: rve; pfam00665 158189005025 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 158189005026 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 158189005027 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 158189005028 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 158189005029 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 158189005030 Membrane transport protein; Region: Mem_trans; cl09117 158189005031 PAS fold; Region: PAS; pfam00989 158189005032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189005033 putative active site [active] 158189005034 heme pocket [chemical binding]; other site 158189005035 PAS domain S-box; Region: sensory_box; TIGR00229 158189005036 PAS domain; Region: PAS; smart00091 158189005037 PAS domain; Region: PAS; smart00091 158189005038 PAS domain; Region: PAS_9; pfam13426 158189005039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189005040 PAS domain; Region: PAS_9; pfam13426 158189005041 putative active site [active] 158189005042 heme pocket [chemical binding]; other site 158189005043 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 158189005044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189005045 Zn2+ binding site [ion binding]; other site 158189005046 Mg2+ binding site [ion binding]; other site 158189005047 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 158189005048 Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones]; Region: Sms; COG1066 158189005049 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158189005050 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 158189005051 Part of AAA domain; Region: AAA_19; pfam13245 158189005052 Family description; Region: UvrD_C_2; pfam13538 158189005053 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 158189005054 Predicted transcriptional regulators [Transcription]; Region: COG1725 158189005055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189005056 DNA-binding site [nucleotide binding]; DNA binding site 158189005057 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 158189005058 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158189005059 Walker A/P-loop; other site 158189005060 ATP binding site [chemical binding]; other site 158189005061 Q-loop/lid; other site 158189005062 ABC transporter signature motif; other site 158189005063 Walker B; other site 158189005064 D-loop; other site 158189005065 H-loop/switch region; other site 158189005066 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 158189005067 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158189005068 inhibitor-cofactor binding pocket; inhibition site 158189005069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189005070 catalytic residue [active] 158189005071 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 158189005072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189005073 catalytic residue [active] 158189005074 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 158189005075 Predicted membrane protein [Function unknown]; Region: COG2364 158189005076 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 158189005077 active site 158189005078 DOMON-like domain of copper-dependent monooxygenases and related proteins; Region: DOMON_DOH; cd09631 158189005079 DOMON domain; Region: DOMON; pfam03351 158189005080 putative ligand binding site [chemical binding]; other site 158189005081 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 158189005082 Beta-lactamase; Region: Beta-lactamase; pfam00144 158189005083 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 158189005084 Protein export membrane protein; Region: SecD_SecF; cl14618 158189005085 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 158189005086 lipoyl-biotinyl attachment site [posttranslational modification]; other site 158189005087 HlyD family secretion protein; Region: HlyD_3; pfam13437 158189005088 Outer membrane efflux protein; Region: OEP; pfam02321 158189005089 Outer membrane efflux protein; Region: OEP; pfam02321 158189005090 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189005091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189005092 metal binding site [ion binding]; metal-binding site 158189005093 active site 158189005094 I-site; other site 158189005095 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158189005096 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158189005097 ligand binding site [chemical binding]; other site 158189005098 flexible hinge region; other site 158189005099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189005100 putative substrate translocation pore; other site 158189005101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158189005102 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 158189005103 AAA domain; Region: AAA_23; pfam13476 158189005104 G1 box; other site 158189005105 GTP/Mg2+ binding site [chemical binding]; other site 158189005106 G2 box; other site 158189005107 Switch I region; other site 158189005108 muropeptide transporter; Validated; Region: ampG; cl17669 158189005109 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158189005110 active site 158189005111 metal binding site [ion binding]; metal-binding site 158189005112 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 158189005113 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 158189005114 putative NAD(P) binding site [chemical binding]; other site 158189005115 CAAX protease self-immunity; Region: Abi; pfam02517 158189005116 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 158189005117 catalytic loop [active] 158189005118 iron binding site [ion binding]; other site 158189005119 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 158189005120 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158189005121 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 158189005122 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158189005123 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 158189005124 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 158189005125 dimer interface [polypeptide binding]; other site 158189005126 [2Fe-2S] cluster binding site [ion binding]; other site 158189005127 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 158189005128 SLBB domain; Region: SLBB; pfam10531 158189005129 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 158189005130 glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316 158189005131 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158189005132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158189005133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189005134 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 158189005135 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 158189005136 putative dimer interface [polypeptide binding]; other site 158189005137 [2Fe-2S] cluster binding site [ion binding]; other site 158189005138 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 158189005139 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158189005140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189005141 Coenzyme A binding pocket [chemical binding]; other site 158189005142 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 158189005143 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 158189005144 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 158189005145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189005146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158189005147 dimer interface [polypeptide binding]; other site 158189005148 phosphorylation site [posttranslational modification] 158189005149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189005150 ATP binding site [chemical binding]; other site 158189005151 Mg2+ binding site [ion binding]; other site 158189005152 G-X-G motif; other site 158189005153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158189005154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189005155 active site 158189005156 phosphorylation site [posttranslational modification] 158189005157 intermolecular recognition site; other site 158189005158 dimerization interface [polypeptide binding]; other site 158189005159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158189005160 DNA binding site [nucleotide binding] 158189005161 short chain dehydrogenase; Provisional; Region: PRK06841 158189005162 classical (c) SDRs; Region: SDR_c; cd05233 158189005163 NAD(P) binding site [chemical binding]; other site 158189005164 active site 158189005165 Class I aldolases; Region: Aldolase_Class_I; cl17187 158189005166 N-acetylneuraminate lyase; Provisional; Region: PRK04147 158189005167 catalytic residue [active] 158189005168 D-mannonate oxidoreductase; Provisional; Region: PRK08277 158189005169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158189005170 NAD(P) binding site [chemical binding]; other site 158189005171 active site 158189005172 DctM-like transporters; Region: DctM; pfam06808 158189005173 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189005174 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 158189005175 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189005176 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158189005177 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158189005178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189005179 DNA-binding site [nucleotide binding]; DNA binding site 158189005180 FCD domain; Region: FCD; pfam07729 158189005181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189005182 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 158189005183 UbiA prenyltransferase family; Region: UbiA; pfam01040 158189005184 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 158189005185 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 158189005186 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 158189005187 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 158189005188 DctM-like transporters; Region: DctM; pfam06808 158189005189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189005190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189005191 metal binding site [ion binding]; metal-binding site 158189005192 active site 158189005193 I-site; other site 158189005194 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 158189005195 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 158189005196 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 158189005197 HlyD family secretion protein; Region: HlyD_3; pfam13437 158189005198 Cation efflux family; Region: Cation_efflux; cl00316 158189005199 S-formylglutathione hydrolase; Region: PLN02442 158189005200 Putative esterase; Region: Esterase; pfam00756 158189005201 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158189005202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189005203 Walker A/P-loop; other site 158189005204 ATP binding site [chemical binding]; other site 158189005205 Q-loop/lid; other site 158189005206 ABC transporter signature motif; other site 158189005207 Walker B; other site 158189005208 D-loop; other site 158189005209 H-loop/switch region; other site 158189005210 TOBE domain; Region: TOBE_2; pfam08402 158189005211 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158189005212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005213 dimer interface [polypeptide binding]; other site 158189005214 conserved gate region; other site 158189005215 putative PBP binding loops; other site 158189005216 ABC-ATPase subunit interface; other site 158189005217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005218 dimer interface [polypeptide binding]; other site 158189005219 conserved gate region; other site 158189005220 putative PBP binding loops; other site 158189005221 ABC-ATPase subunit interface; other site 158189005222 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 158189005223 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158189005224 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 158189005225 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 158189005226 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 158189005227 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 158189005228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 158189005229 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 158189005230 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189005231 Zn2+ binding site [ion binding]; other site 158189005232 Mg2+ binding site [ion binding]; other site 158189005233 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 158189005234 ribonuclease E; Reviewed; Region: rne; PRK10811 158189005235 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 158189005236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189005237 ATP binding site [chemical binding]; other site 158189005238 Mg2+ binding site [ion binding]; other site 158189005239 G-X-G motif; other site 158189005240 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 158189005241 ATP binding site [chemical binding]; other site 158189005242 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 158189005243 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 158189005244 putative acyl-acceptor binding pocket; other site 158189005245 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 158189005246 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158189005247 phosphate binding site [ion binding]; other site 158189005248 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 158189005249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158189005250 putative DNA binding site [nucleotide binding]; other site 158189005251 putative Zn2+ binding site [ion binding]; other site 158189005252 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 158189005253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189005254 catalytic residue [active] 158189005255 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 158189005256 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 158189005257 ligand binding site [chemical binding]; other site 158189005258 NAD binding site [chemical binding]; other site 158189005259 dimerization interface [polypeptide binding]; other site 158189005260 catalytic site [active] 158189005261 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 158189005262 DHH family; Region: DHH; pfam01368 158189005263 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 158189005264 Recombination protein O N terminal; Region: RecO_N; pfam11967 158189005265 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 158189005266 carbamate kinase; Reviewed; Region: PRK12686 158189005267 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 158189005268 putative substrate binding site [chemical binding]; other site 158189005269 nucleotide binding site [chemical binding]; other site 158189005270 nucleotide binding site [chemical binding]; other site 158189005271 homodimer interface [polypeptide binding]; other site 158189005272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189005273 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158189005274 DNA-binding site [nucleotide binding]; DNA binding site 158189005275 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 158189005276 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189005277 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158189005278 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 158189005279 DctM-like transporters; Region: DctM; pfam06808 158189005280 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189005281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189005282 active site 158189005283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189005284 catalytic tetrad [active] 158189005285 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158189005286 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158189005287 inhibitor site; inhibition site 158189005288 active site 158189005289 dimer interface [polypeptide binding]; other site 158189005290 catalytic residue [active] 158189005291 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 158189005292 classical (c) SDRs; Region: SDR_c; cd05233 158189005293 NAD(P) binding site [chemical binding]; other site 158189005294 active site 158189005295 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 158189005296 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 158189005297 Found in ATP-dependent protease La (LON); Region: LON; smart00464 158189005298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189005299 Walker A motif; other site 158189005300 ATP binding site [chemical binding]; other site 158189005301 Walker B motif; other site 158189005302 arginine finger; other site 158189005303 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 158189005304 putative protease; Provisional; Region: PRK15452 158189005305 Peptidase family U32; Region: Peptidase_U32; pfam01136 158189005306 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 158189005307 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 158189005308 DXD motif; other site 158189005309 Nitroreductase family; Region: Nitroreductase; pfam00881 158189005310 FMN binding site [chemical binding]; other site 158189005311 dimer interface [polypeptide binding]; other site 158189005312 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 158189005313 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158189005314 active site 158189005315 HIGH motif; other site 158189005316 nucleotide binding site [chemical binding]; other site 158189005317 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 158189005318 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 158189005319 active site 158189005320 KMSKS motif; other site 158189005321 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 158189005322 tRNA binding surface [nucleotide binding]; other site 158189005323 anticodon binding site; other site 158189005324 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 158189005325 Putative zinc-finger; Region: zf-HC2; pfam13490 158189005326 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 158189005327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 158189005328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158189005329 DNA binding residues [nucleotide binding] 158189005330 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 158189005331 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158189005332 active site 158189005333 HIGH motif; other site 158189005334 nucleotide binding site [chemical binding]; other site 158189005335 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 158189005336 KMSKS motif; other site 158189005337 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 158189005338 tRNA binding surface [nucleotide binding]; other site 158189005339 anticodon binding site; other site 158189005340 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 158189005341 FAD binding domain; Region: FAD_binding_4; pfam01565 158189005342 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 158189005343 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 158189005344 propionate/acetate kinase; Provisional; Region: PRK12379 158189005345 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158189005346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189005347 active site 158189005348 phosphorylation site [posttranslational modification] 158189005349 intermolecular recognition site; other site 158189005350 dimerization interface [polypeptide binding]; other site 158189005351 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158189005352 DNA binding site [nucleotide binding] 158189005353 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 158189005354 XdhC Rossmann domain; Region: XdhC_C; pfam13478 158189005355 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 158189005356 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 158189005357 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 158189005358 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158189005359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189005360 catalytic residue [active] 158189005361 XdhC Rossmann domain; Region: XdhC_C; pfam13478 158189005362 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 158189005363 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 158189005364 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 158189005365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 158189005366 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158189005367 dimerization interface [polypeptide binding]; other site 158189005368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158189005369 dimer interface [polypeptide binding]; other site 158189005370 phosphorylation site [posttranslational modification] 158189005371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189005372 ATP binding site [chemical binding]; other site 158189005373 Mg2+ binding site [ion binding]; other site 158189005374 G-X-G motif; other site 158189005375 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 158189005376 PhoU domain; Region: PhoU; pfam01895 158189005377 PhoU domain; Region: PhoU; pfam01895 158189005378 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 158189005379 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 158189005380 Walker A/P-loop; other site 158189005381 ATP binding site [chemical binding]; other site 158189005382 Q-loop/lid; other site 158189005383 ABC transporter signature motif; other site 158189005384 Walker B; other site 158189005385 D-loop; other site 158189005386 H-loop/switch region; other site 158189005387 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 158189005388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005389 dimer interface [polypeptide binding]; other site 158189005390 conserved gate region; other site 158189005391 putative PBP binding loops; other site 158189005392 ABC-ATPase subunit interface; other site 158189005393 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 158189005394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005395 dimer interface [polypeptide binding]; other site 158189005396 conserved gate region; other site 158189005397 putative PBP binding loops; other site 158189005398 ABC-ATPase subunit interface; other site 158189005399 PBP superfamily domain; Region: PBP_like_2; cl17296 158189005400 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 158189005401 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 158189005402 non-heme iron binding site [ion binding]; other site 158189005403 dimer interface [polypeptide binding]; other site 158189005404 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 158189005405 non-heme iron binding site [ion binding]; other site 158189005406 Isochorismatase family; Region: Isochorismatase; pfam00857 158189005407 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 158189005408 catalytic triad [active] 158189005409 conserved cis-peptide bond; other site 158189005410 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 158189005411 active site 158189005412 multimer interface [polypeptide binding]; other site 158189005413 PAS domain; Region: PAS_10; pfam13596 158189005414 LCCL domain; Region: LCCL; pfam03815 158189005415 LCCL domain; Region: LCCL; cl02694 158189005416 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 158189005417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189005418 metal binding site [ion binding]; metal-binding site 158189005419 active site 158189005420 I-site; other site 158189005421 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158189005422 Predicted permeases [General function prediction only]; Region: COG0679 158189005423 4Fe-4S binding domain; Region: Fer4_5; pfam12801 158189005424 4Fe-4S binding domain; Region: Fer4_5; pfam12801 158189005425 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 158189005426 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 158189005427 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 158189005428 reactive center loop; other site 158189005429 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 158189005430 MFS/sugar transport protein; Region: MFS_2; pfam13347 158189005431 Phosphate acyltransferases; Region: PlsC; smart00563 158189005432 putative acyl-acceptor binding pocket; other site 158189005433 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158189005434 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158189005435 putative acyl-acceptor binding pocket; other site 158189005436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189005437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158189005438 putative substrate translocation pore; other site 158189005439 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 158189005440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189005441 active site 158189005442 catalytic tetrad [active] 158189005443 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158189005444 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189005445 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189005446 active site 158189005447 catalytic tetrad [active] 158189005448 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158189005449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189005450 ATP binding site [chemical binding]; other site 158189005451 putative Mg++ binding site [ion binding]; other site 158189005452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189005453 nucleotide binding region [chemical binding]; other site 158189005454 ATP-binding site [chemical binding]; other site 158189005455 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189005456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189005457 DNA binding site [nucleotide binding] 158189005458 domain linker motif; other site 158189005459 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189005460 ligand binding site [chemical binding]; other site 158189005461 dimerization interface [polypeptide binding]; other site 158189005462 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 158189005463 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 158189005464 dimer interface [polypeptide binding]; other site 158189005465 active site 158189005466 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 158189005467 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 158189005468 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 158189005469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158189005470 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158189005471 Phage-related protein [Function unknown]; Region: COG4695; cl01923 158189005472 threonine synthase; Validated; Region: PRK09225 158189005473 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 158189005474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189005475 catalytic residue [active] 158189005476 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 158189005477 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 158189005478 nucleotide binding site [chemical binding]; other site 158189005479 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 158189005480 dimer interface [polypeptide binding]; other site 158189005481 putative threonine allosteric regulatory site; other site 158189005482 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 158189005483 putative threonine allosteric regulatory site; other site 158189005484 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 158189005485 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 158189005486 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 158189005487 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 158189005488 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158189005489 minor groove reading motif; other site 158189005490 helix-hairpin-helix signature motif; other site 158189005491 substrate binding pocket [chemical binding]; other site 158189005492 active site 158189005493 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 158189005494 Transcriptional regulator [Transcription]; Region: IclR; COG1414 158189005495 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 158189005496 Bacterial transcriptional regulator; Region: IclR; pfam01614 158189005497 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 158189005498 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158189005499 substrate binding site [chemical binding]; other site 158189005500 ATP binding site [chemical binding]; other site 158189005501 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 158189005502 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 158189005503 active site 158189005504 intersubunit interface [polypeptide binding]; other site 158189005505 catalytic residue [active] 158189005506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158189005507 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158189005508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 158189005509 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 158189005510 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 158189005511 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 158189005512 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 158189005513 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 158189005514 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158189005515 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 158189005516 Walker A/P-loop; other site 158189005517 ATP binding site [chemical binding]; other site 158189005518 Q-loop/lid; other site 158189005519 ABC transporter signature motif; other site 158189005520 Walker B; other site 158189005521 D-loop; other site 158189005522 H-loop/switch region; other site 158189005523 TOBE domain; Region: TOBE_2; pfam08402 158189005524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005525 dimer interface [polypeptide binding]; other site 158189005526 conserved gate region; other site 158189005527 putative PBP binding loops; other site 158189005528 ABC-ATPase subunit interface; other site 158189005529 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189005530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005531 dimer interface [polypeptide binding]; other site 158189005532 conserved gate region; other site 158189005533 putative PBP binding loops; other site 158189005534 ABC-ATPase subunit interface; other site 158189005535 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 158189005536 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158189005537 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 158189005538 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 158189005539 Na binding site [ion binding]; other site 158189005540 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 158189005541 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 158189005542 homodimer interface [polypeptide binding]; other site 158189005543 substrate-cofactor binding pocket; other site 158189005544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189005545 catalytic residue [active] 158189005546 Homoserine O-succinyltransferase; Region: HTS; pfam04204 158189005547 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 158189005548 proposed active site lysine [active] 158189005549 conserved cys residue [active] 158189005550 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158189005551 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 158189005552 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 158189005553 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 158189005554 nucleoside/Zn binding site; other site 158189005555 dimer interface [polypeptide binding]; other site 158189005556 catalytic motif [active] 158189005557 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 158189005558 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 158189005559 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 158189005560 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158189005561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189005562 DNA-binding site [nucleotide binding]; DNA binding site 158189005563 FCD domain; Region: FCD; pfam07729 158189005564 Domain of unknown function (DUF386); Region: DUF386; cl01047 158189005565 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 158189005566 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 158189005567 active site 158189005568 catalytic residues [active] 158189005569 glutamyl-tRNA reductase; Region: hemA; TIGR01035 158189005570 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 158189005571 NAD(P) binding pocket [chemical binding]; other site 158189005572 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 158189005573 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 158189005574 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 158189005575 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158189005576 minor groove reading motif; other site 158189005577 helix-hairpin-helix signature motif; other site 158189005578 active site 158189005579 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 158189005580 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 158189005581 dimer interface [polypeptide binding]; other site 158189005582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189005583 catalytic residue [active] 158189005584 Rrf2 family protein; Region: rrf2_super; TIGR00738 158189005585 Transcriptional regulator; Region: Rrf2; pfam02082 158189005586 Rrf2 family protein; Region: rrf2_super; TIGR00738 158189005587 Transcriptional regulator; Region: Rrf2; cl17282 158189005588 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 158189005589 Putative ammonia monooxygenase; Region: AmoA; pfam05145 158189005590 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 158189005591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 158189005592 hypothetical protein; Provisional; Region: PRK13663 158189005593 DJ-1 family protein; Region: not_thiJ; TIGR01383 158189005594 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 158189005595 conserved cys residue [active] 158189005596 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 158189005597 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 158189005598 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 158189005599 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 158189005600 acyl-activating enzyme (AAE) consensus motif; other site 158189005601 putative AMP binding site [chemical binding]; other site 158189005602 putative active site [active] 158189005603 putative CoA binding site [chemical binding]; other site 158189005604 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 158189005605 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 158189005606 ArsC family; Region: ArsC; pfam03960 158189005607 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 158189005608 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158189005609 acyl-activating enzyme (AAE) consensus motif; other site 158189005610 AMP binding site [chemical binding]; other site 158189005611 active site 158189005612 CoA binding site [chemical binding]; other site 158189005613 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 158189005614 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 158189005615 putative dimer interface [polypeptide binding]; other site 158189005616 putative anticodon binding site; other site 158189005617 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 158189005618 homodimer interface [polypeptide binding]; other site 158189005619 motif 1; other site 158189005620 motif 2; other site 158189005621 active site 158189005622 motif 3; other site 158189005623 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158189005624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158189005625 DNA binding residues [nucleotide binding] 158189005626 dimerization interface [polypeptide binding]; other site 158189005627 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 158189005628 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 158189005629 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 158189005630 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 158189005631 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 158189005632 active site 158189005633 ADP/pyrophosphate binding site [chemical binding]; other site 158189005634 dimerization interface [polypeptide binding]; other site 158189005635 allosteric effector site; other site 158189005636 fructose-1,6-bisphosphate binding site; other site 158189005637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189005638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189005639 metal binding site [ion binding]; metal-binding site 158189005640 active site 158189005641 I-site; other site 158189005642 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 158189005643 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 158189005644 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 158189005645 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189005646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005647 dimer interface [polypeptide binding]; other site 158189005648 conserved gate region; other site 158189005649 putative PBP binding loops; other site 158189005650 ABC-ATPase subunit interface; other site 158189005651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005652 dimer interface [polypeptide binding]; other site 158189005653 conserved gate region; other site 158189005654 putative PBP binding loops; other site 158189005655 ABC-ATPase subunit interface; other site 158189005656 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189005657 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189005658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 158189005659 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 158189005660 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189005661 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189005662 DNA binding site [nucleotide binding] 158189005663 domain linker motif; other site 158189005664 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189005665 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189005666 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189005667 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189005668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005669 dimer interface [polypeptide binding]; other site 158189005670 conserved gate region; other site 158189005671 putative PBP binding loops; other site 158189005672 ABC-ATPase subunit interface; other site 158189005673 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189005674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005675 dimer interface [polypeptide binding]; other site 158189005676 conserved gate region; other site 158189005677 putative PBP binding loops; other site 158189005678 ABC-ATPase subunit interface; other site 158189005679 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 158189005680 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158189005681 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158189005682 nucleotide binding site [chemical binding]; other site 158189005683 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 158189005684 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 158189005685 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 158189005686 active site 158189005687 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 158189005688 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 158189005689 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 158189005690 acyl-activating enzyme (AAE) consensus motif; other site 158189005691 putative AMP binding site [chemical binding]; other site 158189005692 putative active site [active] 158189005693 putative CoA binding site [chemical binding]; other site 158189005694 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 158189005695 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 158189005696 Domain of unknown function (DUF814); Region: DUF814; pfam05670 158189005697 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 158189005698 active site 158189005699 metal binding site [ion binding]; metal-binding site 158189005700 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 158189005701 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 158189005702 cytidylate kinase; Provisional; Region: PRK04182 158189005703 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 158189005704 CMP-binding site; other site 158189005705 The sites determining sugar specificity; other site 158189005706 hypothetical protein; Provisional; Region: PRK11820 158189005707 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 158189005708 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 158189005709 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 158189005710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158189005711 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158189005712 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 158189005713 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 158189005714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158189005715 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158189005716 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 158189005717 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 158189005718 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158189005719 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 158189005720 active site 158189005721 DNA polymerase IV; Validated; Region: PRK02406 158189005722 DNA binding site [nucleotide binding] 158189005723 Protein of unknown function (DUF454); Region: DUF454; pfam04304 158189005724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189005725 putative substrate translocation pore; other site 158189005726 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 158189005727 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 158189005728 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 158189005729 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 158189005730 seryl-tRNA synthetase; Provisional; Region: PRK05431 158189005731 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 158189005732 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 158189005733 dimer interface [polypeptide binding]; other site 158189005734 active site 158189005735 motif 1; other site 158189005736 motif 2; other site 158189005737 motif 3; other site 158189005738 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 158189005739 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 158189005740 active site 158189005741 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 158189005742 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 158189005743 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 158189005744 active site 158189005745 metal binding site [ion binding]; metal-binding site 158189005746 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158189005747 gamma-glutamyl kinase; Provisional; Region: PRK05429 158189005748 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 158189005749 nucleotide binding site [chemical binding]; other site 158189005750 homotetrameric interface [polypeptide binding]; other site 158189005751 putative phosphate binding site [ion binding]; other site 158189005752 putative allosteric binding site; other site 158189005753 PUA domain; Region: PUA; pfam01472 158189005754 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 158189005755 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 158189005756 putative catalytic cysteine [active] 158189005757 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 158189005758 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 158189005759 intersubunit interface [polypeptide binding]; other site 158189005760 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 158189005761 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158189005762 ABC-ATPase subunit interface; other site 158189005763 dimer interface [polypeptide binding]; other site 158189005764 putative PBP binding regions; other site 158189005765 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158189005766 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158189005767 Walker A/P-loop; other site 158189005768 ATP binding site [chemical binding]; other site 158189005769 Q-loop/lid; other site 158189005770 ABC transporter signature motif; other site 158189005771 Walker B; other site 158189005772 D-loop; other site 158189005773 H-loop/switch region; other site 158189005774 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 158189005775 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189005776 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 158189005777 active site 158189005778 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 158189005779 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 158189005780 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158189005781 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 158189005782 putative NAD(P) binding site [chemical binding]; other site 158189005783 active site 158189005784 putative substrate binding site [chemical binding]; other site 158189005785 flavoprotein, HI0933 family; Region: TIGR00275 158189005786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158189005787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158189005788 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 158189005789 active site 158189005790 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 158189005791 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 158189005792 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 158189005793 putative hypoxanthine oxidase; Provisional; Region: PRK09800 158189005794 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158189005795 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158189005796 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158189005797 putative oxidoreductase; Provisional; Region: PRK09799 158189005798 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 158189005799 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 158189005800 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 158189005801 active site 158189005802 putative substrate binding pocket [chemical binding]; other site 158189005803 peptidase; Reviewed; Region: PRK13004 158189005804 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 158189005805 putative metal binding site [ion binding]; other site 158189005806 putative dimer interface [polypeptide binding]; other site 158189005807 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189005808 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 158189005809 active site 158189005810 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 158189005811 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 158189005812 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189005813 threonine synthase; Validated; Region: PRK06260 158189005814 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 158189005815 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189005816 catalytic residue [active] 158189005817 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 158189005818 active site 158189005819 Int/Topo IB signature motif; other site 158189005820 catalytic residues [active] 158189005821 DNA binding site [nucleotide binding] 158189005822 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 158189005823 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u5; cd11542 158189005824 metal binding site [ion binding]; metal-binding site 158189005825 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 158189005826 Bacitracin resistance protein BacA; Region: BacA; cl00858 158189005827 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 158189005828 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 158189005829 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158189005830 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158189005831 dimer interface [polypeptide binding]; other site 158189005832 ssDNA binding site [nucleotide binding]; other site 158189005833 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158189005834 ERF superfamily; Region: ERF; pfam04404 158189005835 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189005836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189005837 non-specific DNA binding site [nucleotide binding]; other site 158189005838 salt bridge; other site 158189005839 sequence-specific DNA binding site [nucleotide binding]; other site 158189005840 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 158189005841 MPN+ (JAMM) motif; other site 158189005842 Zinc-binding site [ion binding]; other site 158189005843 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 158189005844 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 158189005845 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 158189005846 Terminase small subunit; Region: Terminase_2; cl01513 158189005847 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 158189005848 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 158189005849 hypothetical protein; Region: PHA00670 158189005850 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 158189005851 major capsid protein; Region: PHA00665 158189005852 hypothetical protein; Region: PHA00664 158189005853 hypothetical protein; Region: PHA00661 158189005854 hypothetical protein; Region: PHA00661 158189005855 crystallin beta/gamma motif-containing protein; Region: PHA00657 158189005856 Predicted helicase [General function prediction only]; Region: COG4889 158189005857 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 158189005858 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189005859 ATP binding site [chemical binding]; other site 158189005860 putative Mg++ binding site [ion binding]; other site 158189005861 helicase superfamily c-terminal domain; Region: HELICc; smart00490 158189005862 ATP-binding site [chemical binding]; other site 158189005863 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 158189005864 active site flap/lid [active] 158189005865 nucleophilic elbow; other site 158189005866 catalytic triad [active] 158189005867 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 158189005868 oxidoreductase; Provisional; Region: PRK06196 158189005869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158189005870 NAD(P) binding site [chemical binding]; other site 158189005871 active site 158189005872 SnoaL-like domain; Region: SnoaL_2; pfam12680 158189005873 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 158189005874 DctM-like transporters; Region: DctM; pfam06808 158189005875 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 158189005876 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 158189005877 carotene isomerase; Region: carot_isom; TIGR02730 158189005878 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158189005879 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 158189005880 active site 158189005881 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 158189005882 intersubunit interface [polypeptide binding]; other site 158189005883 active site 158189005884 zinc binding site [ion binding]; other site 158189005885 Na+ binding site [ion binding]; other site 158189005886 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 158189005887 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 158189005888 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 158189005889 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 158189005890 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 158189005891 23S rRNA binding site [nucleotide binding]; other site 158189005892 L21 binding site [polypeptide binding]; other site 158189005893 L13 binding site [polypeptide binding]; other site 158189005894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 158189005895 binding surface 158189005896 TPR motif; other site 158189005897 Tetratricopeptide repeat; Region: TPR_16; pfam13432 158189005898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158189005899 binding surface 158189005900 TPR repeat; Region: TPR_11; pfam13414 158189005901 TPR motif; other site 158189005902 TPR repeat; Region: TPR_11; pfam13414 158189005903 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 158189005904 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 158189005905 Glycoprotease family; Region: Peptidase_M22; pfam00814 158189005906 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 158189005907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158189005908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189005909 glycogen synthase; Provisional; Region: glgA; PRK00654 158189005910 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 158189005911 ADP-binding pocket [chemical binding]; other site 158189005912 homodimer interface [polypeptide binding]; other site 158189005913 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 158189005914 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 158189005915 ligand binding site; other site 158189005916 oligomer interface; other site 158189005917 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 158189005918 dimer interface [polypeptide binding]; other site 158189005919 N-terminal domain interface [polypeptide binding]; other site 158189005920 sulfate 1 binding site; other site 158189005921 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 158189005922 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 158189005923 putative N- and C-terminal domain interface [polypeptide binding]; other site 158189005924 putative active site [active] 158189005925 MgATP binding site [chemical binding]; other site 158189005926 catalytic site [active] 158189005927 metal binding site [ion binding]; metal-binding site 158189005928 putative carbohydrate binding site [chemical binding]; other site 158189005929 L-arabinose isomerase; Provisional; Region: PRK02929 158189005930 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158189005931 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158189005932 trimer interface [polypeptide binding]; other site 158189005933 substrate binding site [chemical binding]; other site 158189005934 Mn binding site [ion binding]; other site 158189005935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189005936 DNA binding site [nucleotide binding] 158189005937 domain linker motif; other site 158189005938 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158189005939 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189005940 ligand binding site [chemical binding]; other site 158189005941 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 158189005942 Mechanosensitive ion channel; Region: MS_channel; pfam00924 158189005943 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 158189005944 active site 158189005945 8-oxo-dGMP binding site [chemical binding]; other site 158189005946 nudix motif; other site 158189005947 metal binding site [ion binding]; metal-binding site 158189005948 Uncharacterized conserved protein [Function unknown]; Region: COG0062 158189005949 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 158189005950 putative substrate binding site [chemical binding]; other site 158189005951 putative ATP binding site [chemical binding]; other site 158189005952 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 158189005953 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158189005954 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158189005955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005956 dimer interface [polypeptide binding]; other site 158189005957 conserved gate region; other site 158189005958 putative PBP binding loops; other site 158189005959 ABC-ATPase subunit interface; other site 158189005960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189005961 dimer interface [polypeptide binding]; other site 158189005962 conserved gate region; other site 158189005963 putative PBP binding loops; other site 158189005964 ABC-ATPase subunit interface; other site 158189005965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189005966 spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187 158189005967 Walker A/P-loop; other site 158189005968 ATP binding site [chemical binding]; other site 158189005969 Q-loop/lid; other site 158189005970 ABC transporter signature motif; other site 158189005971 Walker B; other site 158189005972 D-loop; other site 158189005973 H-loop/switch region; other site 158189005974 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 158189005975 Caspase domain; Region: Peptidase_C14; pfam00656 158189005976 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 158189005977 excinuclease ABC subunit B; Provisional; Region: PRK05298 158189005978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189005979 ATP binding site [chemical binding]; other site 158189005980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189005981 nucleotide binding region [chemical binding]; other site 158189005982 ATP-binding site [chemical binding]; other site 158189005983 Ultra-violet resistance protein B; Region: UvrB; pfam12344 158189005984 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 158189005985 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 158189005986 protein binding site [polypeptide binding]; other site 158189005987 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158189005988 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 158189005989 putative substrate binding site [chemical binding]; other site 158189005990 putative ATP binding site [chemical binding]; other site 158189005991 HD supefamily hydrolase [General function prediction only]; Region: COG3294 158189005992 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 158189005993 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158189005994 active site 158189005995 HIGH motif; other site 158189005996 nucleotide binding site [chemical binding]; other site 158189005997 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 158189005998 KMSKS motif; other site 158189005999 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 158189006000 Amidohydrolase; Region: Amidohydro_2; pfam04909 158189006001 Rubrerythrin [Energy production and conversion]; Region: COG1592 158189006002 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 158189006003 binuclear metal center [ion binding]; other site 158189006004 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 158189006005 iron binding site [ion binding]; other site 158189006006 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 158189006007 metal binding site 2 [ion binding]; metal-binding site 158189006008 putative DNA binding helix; other site 158189006009 metal binding site 1 [ion binding]; metal-binding site 158189006010 dimer interface [polypeptide binding]; other site 158189006011 structural Zn2+ binding site [ion binding]; other site 158189006012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189006013 S-adenosylmethionine binding site [chemical binding]; other site 158189006014 Cation transport protein; Region: TrkH; cl17365 158189006015 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 158189006016 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 158189006017 active site 158189006018 substrate binding site [chemical binding]; other site 158189006019 metal binding site [ion binding]; metal-binding site 158189006020 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 158189006021 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 158189006022 NAD binding site [chemical binding]; other site 158189006023 homodimer interface [polypeptide binding]; other site 158189006024 active site 158189006025 substrate binding site [chemical binding]; other site 158189006026 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158189006027 active site 158189006028 metal binding site [ion binding]; metal-binding site 158189006029 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 158189006030 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158189006031 active site 158189006032 metal binding site [ion binding]; metal-binding site 158189006033 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 158189006034 hypothetical protein; Validated; Region: PRK00041 158189006035 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 158189006036 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 158189006037 Sugar specificity; other site 158189006038 Pyrimidine base specificity; other site 158189006039 ATP-binding site [chemical binding]; other site 158189006040 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 158189006041 active site 158189006042 catalytic residues [active] 158189006043 GTP-binding protein LepA; Provisional; Region: PRK05433 158189006044 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 158189006045 G1 box; other site 158189006046 putative GEF interaction site [polypeptide binding]; other site 158189006047 GTP/Mg2+ binding site [chemical binding]; other site 158189006048 Switch I region; other site 158189006049 G2 box; other site 158189006050 G3 box; other site 158189006051 Switch II region; other site 158189006052 G4 box; other site 158189006053 G5 box; other site 158189006054 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 158189006055 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 158189006056 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 158189006057 FtsH Extracellular; Region: FtsH_ext; pfam06480 158189006058 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 158189006059 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 158189006060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189006061 Walker A motif; other site 158189006062 ATP binding site [chemical binding]; other site 158189006063 Walker B motif; other site 158189006064 arginine finger; other site 158189006065 Peptidase family M41; Region: Peptidase_M41; pfam01434 158189006066 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 158189006067 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 158189006068 Ligand Binding Site [chemical binding]; other site 158189006069 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 158189006070 putative active site [active] 158189006071 catalytic residue [active] 158189006072 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 158189006073 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 158189006074 5S rRNA interface [nucleotide binding]; other site 158189006075 CTC domain interface [polypeptide binding]; other site 158189006076 L16 interface [polypeptide binding]; other site 158189006077 SpoVG; Region: SpoVG; cl00915 158189006078 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 158189006079 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 158189006080 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 158189006081 ligand binding site [chemical binding]; other site 158189006082 active site 158189006083 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 158189006084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189006085 motif II; other site 158189006086 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 158189006087 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 158189006088 acyl-activating enzyme (AAE) consensus motif; other site 158189006089 putative AMP binding site [chemical binding]; other site 158189006090 putative active site [active] 158189006091 putative CoA binding site [chemical binding]; other site 158189006092 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 158189006093 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 158189006094 active site 158189006095 putative substrate binding pocket [chemical binding]; other site 158189006096 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 158189006097 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 158189006098 glutamate dehydrogenase; Provisional; Region: PRK09414 158189006099 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 158189006100 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 158189006101 NAD(P) binding site [chemical binding]; other site 158189006102 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 158189006103 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 158189006104 non-heme iron binding site [ion binding]; other site 158189006105 dimer interface [polypeptide binding]; other site 158189006106 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 158189006107 non-heme iron binding site [ion binding]; other site 158189006108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189006109 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 158189006110 Walker A/P-loop; other site 158189006111 ATP binding site [chemical binding]; other site 158189006112 Q-loop/lid; other site 158189006113 ABC transporter signature motif; other site 158189006114 Walker B; other site 158189006115 D-loop; other site 158189006116 H-loop/switch region; other site 158189006117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189006118 dimer interface [polypeptide binding]; other site 158189006119 conserved gate region; other site 158189006120 putative PBP binding loops; other site 158189006121 ABC-ATPase subunit interface; other site 158189006122 NMT1/THI5 like; Region: NMT1; pfam09084 158189006123 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 158189006124 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 158189006125 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 158189006126 active site 158189006127 HIGH motif; other site 158189006128 dimer interface [polypeptide binding]; other site 158189006129 KMSKS motif; other site 158189006130 glycyl-tRNA synthetase; Provisional; Region: PRK04173 158189006131 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 158189006132 dimer interface [polypeptide binding]; other site 158189006133 motif 1; other site 158189006134 active site 158189006135 motif 2; other site 158189006136 motif 3; other site 158189006137 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 158189006138 anticodon binding site; other site 158189006139 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 158189006140 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 158189006141 active site 158189006142 HIGH motif; other site 158189006143 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 158189006144 active site 158189006145 KMSKS motif; other site 158189006146 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 158189006147 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158189006148 Esterase/lipase [General function prediction only]; Region: COG1647 158189006149 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158189006150 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158189006151 DNA binding residues [nucleotide binding] 158189006152 dimerization interface [polypeptide binding]; other site 158189006153 RloB-like protein; Region: RloB; pfam13707 158189006154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189006155 AAA domain; Region: AAA_21; pfam13304 158189006156 Walker A/P-loop; other site 158189006157 ATP binding site [chemical binding]; other site 158189006158 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 158189006159 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 158189006160 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 158189006161 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 158189006162 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 158189006163 zinc binding site [ion binding]; other site 158189006164 putative ligand binding site [chemical binding]; other site 158189006165 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 158189006166 zinc binding site [ion binding]; other site 158189006167 putative ligand binding site [chemical binding]; other site 158189006168 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 158189006169 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189006170 TM-ABC transporter signature motif; other site 158189006171 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 158189006172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189006173 Walker A/P-loop; other site 158189006174 ATP binding site [chemical binding]; other site 158189006175 Q-loop/lid; other site 158189006176 ABC transporter signature motif; other site 158189006177 Walker B; other site 158189006178 D-loop; other site 158189006179 H-loop/switch region; other site 158189006180 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 158189006181 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158189006182 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 158189006183 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 158189006184 putative ligand binding site [chemical binding]; other site 158189006185 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189006186 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189006187 Walker A/P-loop; other site 158189006188 ATP binding site [chemical binding]; other site 158189006189 Q-loop/lid; other site 158189006190 ABC transporter signature motif; other site 158189006191 Walker B; other site 158189006192 D-loop; other site 158189006193 H-loop/switch region; other site 158189006194 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189006195 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189006196 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189006197 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189006198 TM-ABC transporter signature motif; other site 158189006199 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189006200 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189006201 DNA binding site [nucleotide binding] 158189006202 domain linker motif; other site 158189006203 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158189006204 ligand binding site [chemical binding]; other site 158189006205 Oligomerisation domain; Region: Oligomerisation; pfam02410 158189006206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 158189006207 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 158189006208 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 158189006209 active site 158189006210 (T/H)XGH motif; other site 158189006211 GTPase CgtA; Reviewed; Region: obgE; PRK12299 158189006212 GTP1/OBG; Region: GTP1_OBG; pfam01018 158189006213 Obg GTPase; Region: Obg; cd01898 158189006214 G1 box; other site 158189006215 GTP/Mg2+ binding site [chemical binding]; other site 158189006216 Switch I region; other site 158189006217 G2 box; other site 158189006218 G3 box; other site 158189006219 Switch II region; other site 158189006220 G4 box; other site 158189006221 G5 box; other site 158189006222 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 158189006223 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 158189006224 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 158189006225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189006226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189006227 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 158189006228 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 158189006229 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 158189006230 KMSK motif region; other site 158189006231 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 158189006232 tRNA binding surface [nucleotide binding]; other site 158189006233 anticodon binding site; other site 158189006234 Biotin operon repressor [Transcription]; Region: BirA; COG1654 158189006235 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 158189006236 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 158189006237 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 158189006238 BioY family; Region: BioY; pfam02632 158189006239 serine O-acetyltransferase; Region: cysE; TIGR01172 158189006240 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 158189006241 trimer interface [polypeptide binding]; other site 158189006242 active site 158189006243 substrate binding site [chemical binding]; other site 158189006244 CoA binding site [chemical binding]; other site 158189006245 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 158189006246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158189006247 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 158189006248 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 158189006249 arogenate dehydrogenase; Region: PLN02256 158189006250 Prephenate dehydrogenase; Region: PDH; pfam02153 158189006251 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 158189006252 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158189006253 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 158189006254 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 158189006255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189006256 S-adenosylmethionine binding site [chemical binding]; other site 158189006257 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 158189006258 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 158189006259 active site 158189006260 substrate binding site [chemical binding]; other site 158189006261 metal binding site [ion binding]; metal-binding site 158189006262 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 158189006263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189006264 motif II; other site 158189006265 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 158189006266 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 158189006267 putative RNA binding site [nucleotide binding]; other site 158189006268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189006269 S-adenosylmethionine binding site [chemical binding]; other site 158189006270 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 158189006271 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 158189006272 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 158189006273 Cl binding site [ion binding]; other site 158189006274 oligomer interface [polypeptide binding]; other site 158189006275 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 158189006276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189006277 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 158189006278 active site 158189006279 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158189006280 phosphate binding site [ion binding]; other site 158189006281 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 158189006282 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 158189006283 FAD binding pocket [chemical binding]; other site 158189006284 conserved FAD binding motif [chemical binding]; other site 158189006285 phosphate binding motif [ion binding]; other site 158189006286 beta-alpha-beta structure motif; other site 158189006287 NAD binding pocket [chemical binding]; other site 158189006288 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 158189006289 dimer interface [polypeptide binding]; other site 158189006290 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158189006291 active site 158189006292 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376 158189006293 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 158189006294 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 158189006295 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 158189006296 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 158189006297 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 158189006298 Chain length determinant protein; Region: Wzz; pfam02706 158189006299 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 158189006300 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 158189006301 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158189006302 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 158189006303 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 158189006304 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158189006305 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 158189006306 putative ligand binding site [chemical binding]; other site 158189006307 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158189006308 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189006309 Walker A/P-loop; other site 158189006310 ATP binding site [chemical binding]; other site 158189006311 Q-loop/lid; other site 158189006312 ABC transporter signature motif; other site 158189006313 Walker B; other site 158189006314 D-loop; other site 158189006315 H-loop/switch region; other site 158189006316 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189006317 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189006318 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189006319 TM-ABC transporter signature motif; other site 158189006320 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189006321 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189006322 TM-ABC transporter signature motif; other site 158189006323 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 158189006324 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 158189006325 putative deacylase active site [active] 158189006326 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 158189006327 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 158189006328 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 158189006329 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 158189006330 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 158189006331 homotrimer interaction site [polypeptide binding]; other site 158189006332 putative active site [active] 158189006333 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 158189006334 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158189006335 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 158189006336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189006337 motif II; other site 158189006338 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 158189006339 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 158189006340 active site 158189006341 dimerization interface [polypeptide binding]; other site 158189006342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189006343 sugar efflux transporter; Region: 2A0120; TIGR00899 158189006344 putative substrate translocation pore; other site 158189006345 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 158189006346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189006347 FeS/SAM binding site; other site 158189006348 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 158189006349 EamA-like transporter family; Region: EamA; pfam00892 158189006350 EamA-like transporter family; Region: EamA; pfam00892 158189006351 Uncharacterized conserved protein [Function unknown]; Region: COG0432 158189006352 aspartate aminotransferase; Provisional; Region: PRK07568 158189006353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158189006354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189006355 homodimer interface [polypeptide binding]; other site 158189006356 catalytic residue [active] 158189006357 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 158189006358 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 158189006359 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158189006360 active site 158189006361 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 158189006362 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 158189006363 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 158189006364 PhoU domain; Region: PhoU; pfam01895 158189006365 argininosuccinate lyase; Provisional; Region: PRK00855 158189006366 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 158189006367 tetramer interface [polypeptide binding]; other site 158189006368 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 158189006369 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158189006370 catalytic residues [active] 158189006371 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189006372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189006373 non-specific DNA binding site [nucleotide binding]; other site 158189006374 salt bridge; other site 158189006375 sequence-specific DNA binding site [nucleotide binding]; other site 158189006376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189006377 H+ Antiporter protein; Region: 2A0121; TIGR00900 158189006378 putative substrate translocation pore; other site 158189006379 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158189006380 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158189006381 dimer interface [polypeptide binding]; other site 158189006382 ssDNA binding site [nucleotide binding]; other site 158189006383 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158189006384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158189006385 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 158189006386 active site 158189006387 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 158189006388 HD domain; Region: HD; pfam01966 158189006389 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158189006390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189006391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189006392 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 158189006393 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 158189006394 N- and C-terminal domain interface [polypeptide binding]; other site 158189006395 active site 158189006396 MgATP binding site [chemical binding]; other site 158189006397 catalytic site [active] 158189006398 metal binding site [ion binding]; metal-binding site 158189006399 xylulose binding site [chemical binding]; other site 158189006400 putative homodimer interface [polypeptide binding]; other site 158189006401 Predicted membrane protein [Function unknown]; Region: COG2246 158189006402 GtrA-like protein; Region: GtrA; pfam04138 158189006403 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 158189006404 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158189006405 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189006406 catalytic residue [active] 158189006407 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 158189006408 intersubunit interface [polypeptide binding]; other site 158189006409 active site 158189006410 Zn2+ binding site [ion binding]; other site 158189006411 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158189006412 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189006413 Predicted membrane protein [Function unknown]; Region: COG2246 158189006414 GtrA-like protein; Region: GtrA; pfam04138 158189006415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189006416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189006417 WHG domain; Region: WHG; pfam13305 158189006418 flavodoxin; Provisional; Region: PRK06242 158189006419 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189006420 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189006421 metal binding site [ion binding]; metal-binding site 158189006422 active site 158189006423 I-site; other site 158189006424 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 158189006425 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 158189006426 active site 158189006427 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 158189006428 active site 158189006429 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189006430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189006431 non-specific DNA binding site [nucleotide binding]; other site 158189006432 salt bridge; other site 158189006433 sequence-specific DNA binding site [nucleotide binding]; other site 158189006434 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 158189006435 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 158189006436 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 158189006437 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 158189006438 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 158189006439 FMN-binding domain; Region: FMN_bind; cl01081 158189006440 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 158189006441 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 158189006442 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 158189006443 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 158189006444 catalytic loop [active] 158189006445 iron binding site [ion binding]; other site 158189006446 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 158189006447 FAD binding pocket [chemical binding]; other site 158189006448 conserved FAD binding motif [chemical binding]; other site 158189006449 phosphate binding motif [ion binding]; other site 158189006450 beta-alpha-beta structure motif; other site 158189006451 NAD binding pocket [chemical binding]; other site 158189006452 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 158189006453 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189006454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189006455 metal binding site [ion binding]; metal-binding site 158189006456 active site 158189006457 I-site; other site 158189006458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158189006459 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 158189006460 dimer interface [polypeptide binding]; other site 158189006461 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 158189006462 dimer interface [polypeptide binding]; other site 158189006463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189006464 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189006465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189006466 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 158189006467 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 158189006468 nucleotide binding site [chemical binding]; other site 158189006469 substrate binding site [chemical binding]; other site 158189006470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189006471 FeS/SAM binding site; other site 158189006472 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 158189006473 active site 158189006474 nucleophile elbow; other site 158189006475 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 158189006476 nucleosidase; Provisional; Region: PRK05634 158189006477 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 158189006478 pyridoxal binding site [chemical binding]; other site 158189006479 dimer interface [polypeptide binding]; other site 158189006480 ATP binding site [chemical binding]; other site 158189006481 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 158189006482 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 158189006483 active site 158189006484 substrate binding site [chemical binding]; other site 158189006485 metal binding site [ion binding]; metal-binding site 158189006486 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 158189006487 additional DNA contacts [nucleotide binding]; other site 158189006488 mismatch recognition site; other site 158189006489 active site 158189006490 zinc binding site [ion binding]; other site 158189006491 DNA intercalation site [nucleotide binding]; other site 158189006492 Hexokinase [Carbohydrate transport and metabolism]; Region: COG5026 158189006493 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158189006494 nucleotide binding site [chemical binding]; other site 158189006495 Hexokinase; Region: Hexokinase_2; pfam03727 158189006496 exonuclease I; Provisional; Region: sbcB; PRK11779 158189006497 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 158189006498 active site 158189006499 catalytic site [active] 158189006500 substrate binding site [chemical binding]; other site 158189006501 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 158189006502 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 158189006503 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 158189006504 substrate-cofactor binding pocket; other site 158189006505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189006506 catalytic residue [active] 158189006507 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158189006508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158189006509 NAD(P) binding site [chemical binding]; other site 158189006510 active site 158189006511 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 158189006512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189006513 non-specific DNA binding site [nucleotide binding]; other site 158189006514 salt bridge; other site 158189006515 sequence-specific DNA binding site [nucleotide binding]; other site 158189006516 Cupin domain; Region: Cupin_2; pfam07883 158189006517 MFS/sugar transport protein; Region: MFS_2; pfam13347 158189006518 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 158189006519 peptide chain release factor 1; Validated; Region: prfA; PRK00591 158189006520 This domain is found in peptide chain release factors; Region: PCRF; smart00937 158189006521 RF-1 domain; Region: RF-1; pfam00472 158189006522 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 158189006523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189006524 S-adenosylmethionine binding site [chemical binding]; other site 158189006525 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 158189006526 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189006527 Zn2+ binding site [ion binding]; other site 158189006528 Mg2+ binding site [ion binding]; other site 158189006529 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 158189006530 synthetase active site [active] 158189006531 NTP binding site [chemical binding]; other site 158189006532 metal binding site [ion binding]; metal-binding site 158189006533 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 158189006534 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 158189006535 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 158189006536 DRTGG domain; Region: DRTGG; pfam07085 158189006537 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 158189006538 DHHA2 domain; Region: DHHA2; pfam02833 158189006539 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 158189006540 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 158189006541 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 158189006542 putative active site [active] 158189006543 catalytic site [active] 158189006544 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 158189006545 putative active site [active] 158189006546 catalytic site [active] 158189006547 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 158189006548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189006549 motif II; other site 158189006550 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 158189006551 active site 158189006552 catalytic motif [active] 158189006553 Zn binding site [ion binding]; other site 158189006554 phenylhydantoinase; Validated; Region: PRK08323 158189006555 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189006556 active site 158189006557 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 158189006558 tetramer interface [polypeptide binding]; other site 158189006559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189006560 catalytic residue [active] 158189006561 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 158189006562 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 158189006563 tetramer interface [polypeptide binding]; other site 158189006564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189006565 catalytic residue [active] 158189006566 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 158189006567 lipoyl attachment site [posttranslational modification]; other site 158189006568 serine hydroxymethyltransferase; Provisional; Region: PRK13580 158189006569 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 158189006570 dimer interface [polypeptide binding]; other site 158189006571 active site 158189006572 glycine-pyridoxal phosphate binding site [chemical binding]; other site 158189006573 folate binding site [chemical binding]; other site 158189006574 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 158189006575 Na2 binding site [ion binding]; other site 158189006576 putative substrate binding site 1 [chemical binding]; other site 158189006577 Na binding site 1 [ion binding]; other site 158189006578 putative substrate binding site 2 [chemical binding]; other site 158189006579 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 158189006580 rRNA binding site [nucleotide binding]; other site 158189006581 predicted 30S ribosome binding site; other site 158189006582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 158189006583 Smr domain; Region: Smr; pfam01713 158189006584 FOG: CBS domain [General function prediction only]; Region: COG0517 158189006585 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 158189006586 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 158189006587 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 158189006588 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 158189006589 Walker A/P-loop; other site 158189006590 ATP binding site [chemical binding]; other site 158189006591 Q-loop/lid; other site 158189006592 ABC transporter signature motif; other site 158189006593 Walker B; other site 158189006594 D-loop; other site 158189006595 H-loop/switch region; other site 158189006596 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 158189006597 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 158189006598 Walker A/P-loop; other site 158189006599 ATP binding site [chemical binding]; other site 158189006600 Q-loop/lid; other site 158189006601 ABC transporter signature motif; other site 158189006602 Walker B; other site 158189006603 D-loop; other site 158189006604 H-loop/switch region; other site 158189006605 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 158189006606 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189006607 TM-ABC transporter signature motif; other site 158189006608 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189006609 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 158189006610 TM-ABC transporter signature motif; other site 158189006611 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 158189006612 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 158189006613 putative ligand binding site [chemical binding]; other site 158189006614 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 158189006615 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 158189006616 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 158189006617 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 158189006618 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 158189006619 active site 158189006620 SCP-2 sterol transfer family; Region: SCP2; pfam02036 158189006621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189006622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189006623 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 158189006624 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 158189006625 active site 158189006626 interdomain interaction site; other site 158189006627 putative metal-binding site [ion binding]; other site 158189006628 nucleotide binding site [chemical binding]; other site 158189006629 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 158189006630 domain I; other site 158189006631 DNA binding groove [nucleotide binding] 158189006632 phosphate binding site [ion binding]; other site 158189006633 domain II; other site 158189006634 domain III; other site 158189006635 nucleotide binding site [chemical binding]; other site 158189006636 catalytic site [active] 158189006637 domain IV; other site 158189006638 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 158189006639 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 158189006640 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 158189006641 B12 binding site [chemical binding]; other site 158189006642 GTP-binding protein YchF; Reviewed; Region: PRK09601 158189006643 YchF GTPase; Region: YchF; cd01900 158189006644 G1 box; other site 158189006645 GTP/Mg2+ binding site [chemical binding]; other site 158189006646 Switch I region; other site 158189006647 G2 box; other site 158189006648 Switch II region; other site 158189006649 G3 box; other site 158189006650 G4 box; other site 158189006651 G5 box; other site 158189006652 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 158189006653 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 158189006654 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 158189006655 HflX GTPase family; Region: HflX; cd01878 158189006656 G1 box; other site 158189006657 GTP/Mg2+ binding site [chemical binding]; other site 158189006658 Switch I region; other site 158189006659 G2 box; other site 158189006660 G3 box; other site 158189006661 Switch II region; other site 158189006662 G4 box; other site 158189006663 G5 box; other site 158189006664 OPT oligopeptide transporter protein; Region: OPT; cl14607 158189006665 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 158189006666 OPT oligopeptide transporter protein; Region: OPT; cl14607 158189006667 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 158189006668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189006669 FeS/SAM binding site; other site 158189006670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189006671 H+ Antiporter protein; Region: 2A0121; TIGR00900 158189006672 putative substrate translocation pore; other site 158189006673 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 158189006674 DNA binding residues [nucleotide binding] 158189006675 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 158189006676 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 158189006677 DNA binding residues [nucleotide binding] 158189006678 alanyl-tRNA synthetase; Provisional; Region: PRK01584 158189006679 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 158189006680 motif 1; other site 158189006681 active site 158189006682 motif 2; other site 158189006683 motif 3; other site 158189006684 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 158189006685 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 158189006686 DNA protecting protein DprA; Region: dprA; TIGR00732 158189006687 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158189006688 endonuclease III; Region: ENDO3c; smart00478 158189006689 minor groove reading motif; other site 158189006690 helix-hairpin-helix signature motif; other site 158189006691 substrate binding pocket [chemical binding]; other site 158189006692 active site 158189006693 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 158189006694 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158189006695 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158189006696 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158189006697 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158189006698 ligand binding site [chemical binding]; other site 158189006699 flexible hinge region; other site 158189006700 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 158189006701 putative switch regulator; other site 158189006702 non-specific DNA interactions [nucleotide binding]; other site 158189006703 DNA binding site [nucleotide binding] 158189006704 sequence specific DNA binding site [nucleotide binding]; other site 158189006705 putative cAMP binding site [chemical binding]; other site 158189006706 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158189006707 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158189006708 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158189006709 putative active site [active] 158189006710 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cl01007 158189006711 SxDxEG motif; other site 158189006712 active site 158189006713 metal binding site [ion binding]; metal-binding site 158189006714 homopentamer interface [polypeptide binding]; other site 158189006715 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158189006716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189006717 putative PBP binding loops; other site 158189006718 dimer interface [polypeptide binding]; other site 158189006719 ABC-ATPase subunit interface; other site 158189006720 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 158189006721 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 158189006722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189006723 dimer interface [polypeptide binding]; other site 158189006724 conserved gate region; other site 158189006725 putative PBP binding loops; other site 158189006726 ABC-ATPase subunit interface; other site 158189006727 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 158189006728 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158189006729 Walker A/P-loop; other site 158189006730 ATP binding site [chemical binding]; other site 158189006731 Q-loop/lid; other site 158189006732 ABC transporter signature motif; other site 158189006733 Walker B; other site 158189006734 D-loop; other site 158189006735 H-loop/switch region; other site 158189006736 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 158189006737 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 158189006738 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158189006739 Walker A/P-loop; other site 158189006740 ATP binding site [chemical binding]; other site 158189006741 Q-loop/lid; other site 158189006742 ABC transporter signature motif; other site 158189006743 Walker B; other site 158189006744 D-loop; other site 158189006745 H-loop/switch region; other site 158189006746 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158189006747 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 158189006748 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 158189006749 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 158189006750 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 158189006751 oligomer interface [polypeptide binding]; other site 158189006752 active site 158189006753 metal binding site [ion binding]; metal-binding site 158189006754 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158189006755 AAA domain; Region: AAA_21; pfam13304 158189006756 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 158189006757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189006758 motif II; other site 158189006759 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158189006760 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 158189006761 Walker A/P-loop; other site 158189006762 ATP binding site [chemical binding]; other site 158189006763 Q-loop/lid; other site 158189006764 ABC transporter signature motif; other site 158189006765 Walker B; other site 158189006766 D-loop; other site 158189006767 H-loop/switch region; other site 158189006768 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 158189006769 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 158189006770 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 158189006771 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158189006772 active site 158189006773 phosphorylation site [posttranslational modification] 158189006774 putative oxidoreductase; Provisional; Region: PRK12831 158189006775 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158189006776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158189006777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189006778 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 158189006779 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 158189006780 FAD binding pocket [chemical binding]; other site 158189006781 FAD binding motif [chemical binding]; other site 158189006782 phosphate binding motif [ion binding]; other site 158189006783 beta-alpha-beta structure motif; other site 158189006784 NAD binding pocket [chemical binding]; other site 158189006785 Iron coordination center [ion binding]; other site 158189006786 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 158189006787 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 158189006788 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 158189006789 putative dimer interface [polypeptide binding]; other site 158189006790 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 158189006791 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 158189006792 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 158189006793 dimerization interface [polypeptide binding]; other site 158189006794 ATP binding site [chemical binding]; other site 158189006795 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 158189006796 dimerization interface [polypeptide binding]; other site 158189006797 ATP binding site [chemical binding]; other site 158189006798 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 158189006799 conserved cys residue [active] 158189006800 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 158189006801 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 158189006802 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 158189006803 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 158189006804 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 158189006805 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 158189006806 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 158189006807 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 158189006808 active site 158189006809 substrate binding site [chemical binding]; other site 158189006810 cosubstrate binding site; other site 158189006811 catalytic site [active] 158189006812 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 158189006813 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 158189006814 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 158189006815 dimerization interface [polypeptide binding]; other site 158189006816 putative ATP binding site [chemical binding]; other site 158189006817 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 158189006818 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 158189006819 active site 158189006820 tetramer interface [polypeptide binding]; other site 158189006821 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158189006822 active site 158189006823 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 158189006824 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 158189006825 ATP binding site [chemical binding]; other site 158189006826 active site 158189006827 substrate binding site [chemical binding]; other site 158189006828 AIR carboxylase; Region: AIRC; cl00310 158189006829 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 158189006830 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158189006831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189006832 Walker A/P-loop; other site 158189006833 ATP binding site [chemical binding]; other site 158189006834 ABC transporter signature motif; other site 158189006835 Walker B; other site 158189006836 D-loop; other site 158189006837 H-loop/switch region; other site 158189006838 ABC transporter; Region: ABC_tran_2; pfam12848 158189006839 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158189006840 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 158189006841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189006842 FeS/SAM binding site; other site 158189006843 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 158189006844 AMMECR1; Region: AMMECR1; pfam01871 158189006845 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 158189006846 putative ligand binding pocket/active site [active] 158189006847 putative metal binding site [ion binding]; other site 158189006848 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 158189006849 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 158189006850 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 158189006851 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189006852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189006853 dimer interface [polypeptide binding]; other site 158189006854 conserved gate region; other site 158189006855 putative PBP binding loops; other site 158189006856 ABC-ATPase subunit interface; other site 158189006857 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189006858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189006859 dimer interface [polypeptide binding]; other site 158189006860 conserved gate region; other site 158189006861 putative PBP binding loops; other site 158189006862 ABC-ATPase subunit interface; other site 158189006863 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189006864 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158189006865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189006866 active site 158189006867 phosphorylation site [posttranslational modification] 158189006868 intermolecular recognition site; other site 158189006869 dimerization interface [polypeptide binding]; other site 158189006870 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158189006871 DNA binding residues [nucleotide binding] 158189006872 dimerization interface [polypeptide binding]; other site 158189006873 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189006874 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189006875 ligand binding site [chemical binding]; other site 158189006876 dimerization interface [polypeptide binding]; other site 158189006877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189006878 Histidine kinase; Region: HisKA_3; pfam07730 158189006879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189006880 ATP binding site [chemical binding]; other site 158189006881 Mg2+ binding site [ion binding]; other site 158189006882 G-X-G motif; other site 158189006883 TrkA-N domain; Region: TrkA_N; pfam02254 158189006884 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 158189006885 TrkA-C domain; Region: TrkA_C; pfam02080 158189006886 TrkA-N domain; Region: TrkA_N; pfam02254 158189006887 TrkA-C domain; Region: TrkA_C; pfam02080 158189006888 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 158189006889 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 158189006890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189006891 WHG domain; Region: WHG; pfam13305 158189006892 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 158189006893 fructuronate transporter; Provisional; Region: PRK10034; cl15264 158189006894 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 158189006895 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 158189006896 A new structural DNA glycosylase; Region: AlkD_like; cd06561 158189006897 active site 158189006898 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 158189006899 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 158189006900 active site 158189006901 dimer interface [polypeptide binding]; other site 158189006902 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 158189006903 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158189006904 catalytic residues [active] 158189006905 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 158189006906 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 158189006907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189006908 catalytic residue [active] 158189006909 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 158189006910 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 158189006911 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 158189006912 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 158189006913 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 158189006914 classical (c) SDRs; Region: SDR_c; cd05233 158189006915 NAD(P) binding site [chemical binding]; other site 158189006916 active site 158189006917 EamA-like transporter family; Region: EamA; pfam00892 158189006918 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 158189006919 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 158189006920 Walker A/P-loop; other site 158189006921 ATP binding site [chemical binding]; other site 158189006922 Q-loop/lid; other site 158189006923 ABC transporter signature motif; other site 158189006924 Walker B; other site 158189006925 D-loop; other site 158189006926 H-loop/switch region; other site 158189006927 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 158189006928 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 158189006929 Walker A/P-loop; other site 158189006930 ATP binding site [chemical binding]; other site 158189006931 Q-loop/lid; other site 158189006932 ABC transporter signature motif; other site 158189006933 Walker B; other site 158189006934 D-loop; other site 158189006935 H-loop/switch region; other site 158189006936 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 158189006937 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 158189006938 TM-ABC transporter signature motif; other site 158189006939 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189006940 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 158189006941 TM-ABC transporter signature motif; other site 158189006942 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 158189006943 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189006944 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158189006945 inhibitor site; inhibition site 158189006946 active site 158189006947 dimer interface [polypeptide binding]; other site 158189006948 catalytic residue [active] 158189006949 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158189006950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158189006951 active site 158189006952 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 158189006953 amidohydrolase; Region: amidohydrolases; TIGR01891 158189006954 metal binding site [ion binding]; metal-binding site 158189006955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189006956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189006957 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 158189006958 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 158189006959 active site 158189006960 RecX family; Region: RecX; cl00936 158189006961 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 158189006962 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 158189006963 23S rRNA interface [nucleotide binding]; other site 158189006964 L3 interface [polypeptide binding]; other site 158189006965 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158189006966 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 158189006967 Part of AAA domain; Region: AAA_19; pfam13245 158189006968 Family description; Region: UvrD_C_2; pfam13538 158189006969 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 158189006970 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 158189006971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189006972 FeS/SAM binding site; other site 158189006973 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 158189006974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189006975 dimer interface [polypeptide binding]; other site 158189006976 conserved gate region; other site 158189006977 putative PBP binding loops; other site 158189006978 ABC-ATPase subunit interface; other site 158189006979 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 158189006980 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 158189006981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189006982 dimer interface [polypeptide binding]; other site 158189006983 conserved gate region; other site 158189006984 putative PBP binding loops; other site 158189006985 ABC-ATPase subunit interface; other site 158189006986 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 158189006987 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158189006988 Walker A/P-loop; other site 158189006989 ATP binding site [chemical binding]; other site 158189006990 Q-loop/lid; other site 158189006991 ABC transporter signature motif; other site 158189006992 Walker B; other site 158189006993 D-loop; other site 158189006994 H-loop/switch region; other site 158189006995 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 158189006996 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 158189006997 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158189006998 Walker A/P-loop; other site 158189006999 ATP binding site [chemical binding]; other site 158189007000 Q-loop/lid; other site 158189007001 ABC transporter signature motif; other site 158189007002 Walker B; other site 158189007003 D-loop; other site 158189007004 H-loop/switch region; other site 158189007005 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 158189007006 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 158189007007 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 158189007008 peptide binding site [polypeptide binding]; other site 158189007009 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 158189007010 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 158189007011 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 158189007012 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 158189007013 tetramer interface [polypeptide binding]; other site 158189007014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189007015 catalytic residue [active] 158189007016 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 158189007017 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 158189007018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158189007019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189007020 homodimer interface [polypeptide binding]; other site 158189007021 catalytic residue [active] 158189007022 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 158189007023 active site 158189007024 catalytic triad [active] 158189007025 oxyanion hole [active] 158189007026 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 158189007027 active site 158189007028 intersubunit interactions; other site 158189007029 catalytic residue [active] 158189007030 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189007031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189007032 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189007033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189007034 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189007035 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189007036 active site 158189007037 catalytic tetrad [active] 158189007038 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158189007039 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 158189007040 putative NAD(P) binding site [chemical binding]; other site 158189007041 catalytic Zn binding site [ion binding]; other site 158189007042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189007043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189007044 DNA binding site [nucleotide binding] 158189007045 domain linker motif; other site 158189007046 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189007047 ligand binding site [chemical binding]; other site 158189007048 dimerization interface [polypeptide binding]; other site 158189007049 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007050 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189007051 TM-ABC transporter signature motif; other site 158189007052 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189007053 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189007054 Walker A/P-loop; other site 158189007055 ATP binding site [chemical binding]; other site 158189007056 Q-loop/lid; other site 158189007057 ABC transporter signature motif; other site 158189007058 Walker B; other site 158189007059 D-loop; other site 158189007060 H-loop/switch region; other site 158189007061 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189007062 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 158189007063 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189007064 putative ligand binding site [chemical binding]; other site 158189007065 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 158189007066 N- and C-terminal domain interface [polypeptide binding]; other site 158189007067 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 158189007068 active site 158189007069 putative catalytic site [active] 158189007070 metal binding site [ion binding]; metal-binding site 158189007071 ATP binding site [chemical binding]; other site 158189007072 carbohydrate binding site [chemical binding]; other site 158189007073 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 158189007074 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158189007075 putative NAD(P) binding site [chemical binding]; other site 158189007076 catalytic Zn binding site [ion binding]; other site 158189007077 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 158189007078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158189007079 NAD(P) binding site [chemical binding]; other site 158189007080 active site 158189007081 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 158189007082 active site 158189007083 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 158189007084 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 158189007085 tetramer interface [polypeptide binding]; other site 158189007086 TPP-binding site [chemical binding]; other site 158189007087 heterodimer interface [polypeptide binding]; other site 158189007088 phosphorylation loop region [posttranslational modification] 158189007089 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 158189007090 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 158189007091 PYR/PP interface [polypeptide binding]; other site 158189007092 dimer interface [polypeptide binding]; other site 158189007093 TPP binding site [chemical binding]; other site 158189007094 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158189007095 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 158189007096 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158189007097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189007098 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158189007099 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 158189007100 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 158189007101 E3 interaction surface; other site 158189007102 lipoyl attachment site [posttranslational modification]; other site 158189007103 e3 binding domain; Region: E3_binding; pfam02817 158189007104 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 158189007105 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158189007106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189007107 DNA-binding site [nucleotide binding]; DNA binding site 158189007108 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158189007109 Domain of unknown function (DUF718); Region: DUF718; pfam05336 158189007110 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007111 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189007112 TM-ABC transporter signature motif; other site 158189007113 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007114 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189007115 TM-ABC transporter signature motif; other site 158189007116 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189007117 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189007118 Walker A/P-loop; other site 158189007119 ATP binding site [chemical binding]; other site 158189007120 Q-loop/lid; other site 158189007121 ABC transporter signature motif; other site 158189007122 Walker B; other site 158189007123 D-loop; other site 158189007124 H-loop/switch region; other site 158189007125 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189007126 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 158189007127 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 158189007128 ligand binding site [chemical binding]; other site 158189007129 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 158189007130 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 158189007131 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 158189007132 L-rhamnose isomerase; Provisional; Region: PRK01076 158189007133 transcriptional activator RhaS; Provisional; Region: PRK13503 158189007134 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158189007135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189007136 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 158189007137 L-fucose isomerase; Provisional; Region: fucI; PRK10991 158189007138 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158189007139 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158189007140 trimer interface [polypeptide binding]; other site 158189007141 substrate binding site [chemical binding]; other site 158189007142 Mn binding site [ion binding]; other site 158189007143 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 158189007144 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 158189007145 Part of AAA domain; Region: AAA_19; pfam13245 158189007146 Family description; Region: UvrD_C_2; pfam13538 158189007147 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 158189007148 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 158189007149 CAAX protease self-immunity; Region: Abi; pfam02517 158189007150 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 158189007151 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 158189007152 putative dimer interface [polypeptide binding]; other site 158189007153 catalytic triad [active] 158189007154 enolase; Provisional; Region: eno; PRK00077 158189007155 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 158189007156 dimer interface [polypeptide binding]; other site 158189007157 metal binding site [ion binding]; metal-binding site 158189007158 substrate binding pocket [chemical binding]; other site 158189007159 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 158189007160 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 158189007161 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 158189007162 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158189007163 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 158189007164 active site 158189007165 trimer interface [polypeptide binding]; other site 158189007166 allosteric site; other site 158189007167 active site lid [active] 158189007168 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158189007169 mannonate dehydratase; Provisional; Region: PRK03906 158189007170 mannonate dehydratase; Region: uxuA; TIGR00695 158189007171 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158189007172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189007173 DNA-binding site [nucleotide binding]; DNA binding site 158189007174 FCD domain; Region: FCD; pfam07729 158189007175 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 158189007176 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 158189007177 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 158189007178 Uncharacterized conserved protein [Function unknown]; Region: COG1284 158189007179 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 158189007180 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 158189007181 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 158189007182 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 158189007183 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 158189007184 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 158189007185 putative FMN binding site [chemical binding]; other site 158189007186 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 158189007187 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 158189007188 active site 158189007189 substrate binding site [chemical binding]; other site 158189007190 Mg2+ binding site [ion binding]; other site 158189007191 alpha-glucosidase; Provisional; Region: PRK10426 158189007192 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 158189007193 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 158189007194 putative active site [active] 158189007195 putative catalytic site [active] 158189007196 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189007197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189007198 dimer interface [polypeptide binding]; other site 158189007199 conserved gate region; other site 158189007200 putative PBP binding loops; other site 158189007201 ABC-ATPase subunit interface; other site 158189007202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189007203 dimer interface [polypeptide binding]; other site 158189007204 conserved gate region; other site 158189007205 putative PBP binding loops; other site 158189007206 ABC-ATPase subunit interface; other site 158189007207 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189007208 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189007209 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158189007210 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158189007211 trimer interface [polypeptide binding]; other site 158189007212 substrate binding site [chemical binding]; other site 158189007213 Mn binding site [ion binding]; other site 158189007214 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158189007215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158189007216 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158189007217 transketolase; Reviewed; Region: PRK05899 158189007218 TPP-binding site [chemical binding]; other site 158189007219 dimer interface [polypeptide binding]; other site 158189007220 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 158189007221 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158189007222 PYR/PP interface [polypeptide binding]; other site 158189007223 dimer interface [polypeptide binding]; other site 158189007224 TPP binding site [chemical binding]; other site 158189007225 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158189007226 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 158189007227 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 158189007228 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 158189007229 putative active site [active] 158189007230 metal binding site [ion binding]; metal-binding site 158189007231 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 158189007232 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 158189007233 elongation factor G; Reviewed; Region: PRK12740 158189007234 G1 box; other site 158189007235 putative GEF interaction site [polypeptide binding]; other site 158189007236 GTP/Mg2+ binding site [chemical binding]; other site 158189007237 Switch I region; other site 158189007238 G2 box; other site 158189007239 G3 box; other site 158189007240 Switch II region; other site 158189007241 G4 box; other site 158189007242 G5 box; other site 158189007243 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 158189007244 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 158189007245 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 158189007246 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 158189007247 HIT family signature motif; other site 158189007248 catalytic residue [active] 158189007249 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 158189007250 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 158189007251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189007252 motif II; other site 158189007253 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 158189007254 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 158189007255 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 158189007256 Fumarase C-terminus; Region: Fumerase_C; pfam05683 158189007257 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 158189007258 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 158189007259 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 158189007260 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 158189007261 active site 158189007262 nucleophile elbow; other site 158189007263 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 158189007264 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 158189007265 putative active site [active] 158189007266 substrate binding site [chemical binding]; other site 158189007267 putative cosubstrate binding site; other site 158189007268 catalytic site [active] 158189007269 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 158189007270 substrate binding site [chemical binding]; other site 158189007271 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 158189007272 active site 158189007273 catalytic residues [active] 158189007274 metal binding site [ion binding]; metal-binding site 158189007275 primosome assembly protein PriA; Validated; Region: PRK05580 158189007276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189007277 ATP binding site [chemical binding]; other site 158189007278 putative Mg++ binding site [ion binding]; other site 158189007279 helicase superfamily c-terminal domain; Region: HELICc; smart00490 158189007280 ATP-binding site [chemical binding]; other site 158189007281 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 158189007282 Fe-S cluster binding site [ion binding]; other site 158189007283 active site 158189007284 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 158189007285 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 158189007286 dimerization interface 3.5A [polypeptide binding]; other site 158189007287 active site 158189007288 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 158189007289 Uncharacterized conserved protein [Function unknown]; Region: COG1624 158189007290 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 158189007291 glycerol kinase; Provisional; Region: glpK; PRK00047 158189007292 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 158189007293 N- and C-terminal domain interface [polypeptide binding]; other site 158189007294 active site 158189007295 MgATP binding site [chemical binding]; other site 158189007296 catalytic site [active] 158189007297 metal binding site [ion binding]; metal-binding site 158189007298 glycerol binding site [chemical binding]; other site 158189007299 homotetramer interface [polypeptide binding]; other site 158189007300 homodimer interface [polypeptide binding]; other site 158189007301 FBP binding site [chemical binding]; other site 158189007302 protein IIAGlc interface [polypeptide binding]; other site 158189007303 DRTGG domain; Region: DRTGG; pfam07085 158189007304 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 158189007305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189007306 ATP binding site [chemical binding]; other site 158189007307 G-X-G motif; other site 158189007308 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189007309 4Fe-4S binding domain; Region: Fer4; pfam00037 158189007310 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158189007311 Putative Fe-S cluster; Region: FeS; cl17515 158189007312 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 158189007313 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 158189007314 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 158189007315 Peptidase M16C associated; Region: M16C_assoc; pfam08367 158189007316 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 158189007317 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 158189007318 endonuclease IV; Provisional; Region: PRK01060 158189007319 AP (apurinic/apyrimidinic) site pocket; other site 158189007320 DNA interaction; other site 158189007321 Metal-binding active site; metal-binding site 158189007322 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158189007323 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 158189007324 active site 158189007325 catalytic site [active] 158189007326 peptidase T; Region: peptidase-T; TIGR01882 158189007327 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 158189007328 metal binding site [ion binding]; metal-binding site 158189007329 dimer interface [polypeptide binding]; other site 158189007330 Transposase [DNA replication, recombination, and repair]; Region: COG5421 158189007331 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 158189007332 catalytic loop [active] 158189007333 iron binding site [ion binding]; other site 158189007334 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 158189007335 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 158189007336 4Fe-4S binding domain; Region: Fer4; pfam00037 158189007337 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158189007338 4Fe-4S binding domain; Region: Fer4; pfam00037 158189007339 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158189007340 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 158189007341 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 158189007342 dimer interface [polypeptide binding]; other site 158189007343 [2Fe-2S] cluster binding site [ion binding]; other site 158189007344 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 158189007345 SLBB domain; Region: SLBB; pfam10531 158189007346 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 158189007347 4Fe-4S binding domain; Region: Fer4; pfam00037 158189007348 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189007349 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 158189007350 dimer interface [polypeptide binding]; other site 158189007351 [2Fe-2S] cluster binding site [ion binding]; other site 158189007352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189007353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189007354 ATP binding site [chemical binding]; other site 158189007355 Mg2+ binding site [ion binding]; other site 158189007356 G-X-G motif; other site 158189007357 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 158189007358 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 158189007359 putative dimer interface [polypeptide binding]; other site 158189007360 [2Fe-2S] cluster binding site [ion binding]; other site 158189007361 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 158189007362 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 158189007363 CoA binding domain; Region: CoA_binding; pfam02629 158189007364 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 158189007365 putative catalytic site [active] 158189007366 putative metal binding site [ion binding]; other site 158189007367 putative phosphate binding site [ion binding]; other site 158189007368 HEAT repeats; Region: HEAT_2; pfam13646 158189007369 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 158189007370 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 158189007371 oligomer interface [polypeptide binding]; other site 158189007372 active site residues [active] 158189007373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189007374 Walker A/P-loop; other site 158189007375 ATP binding site [chemical binding]; other site 158189007376 GTPase Era; Reviewed; Region: era; PRK00089 158189007377 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 158189007378 G1 box; other site 158189007379 GTP/Mg2+ binding site [chemical binding]; other site 158189007380 Switch I region; other site 158189007381 G2 box; other site 158189007382 Switch II region; other site 158189007383 G3 box; other site 158189007384 G4 box; other site 158189007385 G5 box; other site 158189007386 KH domain; Region: KH_2; pfam07650 158189007387 G-X-X-G motif; other site 158189007388 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 158189007389 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158189007390 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 158189007391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158189007392 active site 158189007393 nucleotide binding site [chemical binding]; other site 158189007394 HIGH motif; other site 158189007395 KMSKS motif; other site 158189007396 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 158189007397 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 158189007398 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 158189007399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158189007400 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 158189007401 Surface antigen; Region: Bac_surface_Ag; pfam01103 158189007402 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 158189007403 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 158189007404 active site 158189007405 catalytic residues [active] 158189007406 DNA binding site [nucleotide binding] 158189007407 Int/Topo IB signature motif; other site 158189007408 Helix-turn-helix domain; Region: HTH_17; pfam12728 158189007409 Helix-turn-helix domain; Region: HTH_17; pfam12728 158189007410 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 158189007411 replicative DNA helicase; Region: DnaB; TIGR00665 158189007412 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 158189007413 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 158189007414 Walker A motif; other site 158189007415 ATP binding site [chemical binding]; other site 158189007416 Walker B motif; other site 158189007417 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158189007418 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158189007419 dimer interface [polypeptide binding]; other site 158189007420 ssDNA binding site [nucleotide binding]; other site 158189007421 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158189007422 NinB protein; Region: NinB; pfam05772 158189007423 ERF superfamily; Region: ERF; pfam04404 158189007424 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 158189007425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189007426 non-specific DNA binding site [nucleotide binding]; other site 158189007427 salt bridge; other site 158189007428 sequence-specific DNA binding site [nucleotide binding]; other site 158189007429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 158189007430 Integrase core domain; Region: rve; pfam00665 158189007431 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 158189007432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189007433 Walker A motif; other site 158189007434 ATP binding site [chemical binding]; other site 158189007435 Walker B motif; other site 158189007436 arginine finger; other site 158189007437 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 158189007438 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 158189007439 MPN+ (JAMM) motif; other site 158189007440 Zinc-binding site [ion binding]; other site 158189007441 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 158189007442 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 158189007443 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 158189007444 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 158189007445 DNA methylase; Region: N6_N4_Mtase; pfam01555 158189007446 DNA methylase; Region: N6_N4_Mtase; pfam01555 158189007447 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 158189007448 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 158189007449 ATP binding site [chemical binding]; other site 158189007450 putative Mg++ binding site [ion binding]; other site 158189007451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189007452 TIR domain; Region: TIR_2; pfam13676 158189007453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189007454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189007455 Walker A motif; other site 158189007456 ATP binding site [chemical binding]; other site 158189007457 Walker B motif; other site 158189007458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 158189007459 Integrase core domain; Region: rve; pfam00665 158189007460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 158189007461 putative Mg++ binding site [ion binding]; other site 158189007462 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 158189007463 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 158189007464 putative homodimer interface [polypeptide binding]; other site 158189007465 putative active site [active] 158189007466 catalytic site [active] 158189007467 Transposase IS200 like; Region: Y1_Tnp; pfam01797 158189007468 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 158189007469 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 158189007470 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158189007471 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158189007472 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 158189007473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158189007474 binding surface 158189007475 TPR motif; other site 158189007476 Tetratricopeptide repeat; Region: TPR_12; pfam13424 158189007477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158189007478 binding surface 158189007479 TPR motif; other site 158189007480 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189007481 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189007482 ligand binding site [chemical binding]; other site 158189007483 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 158189007484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158189007485 TPR motif; other site 158189007486 binding surface 158189007487 RNA polymerase sigma factor; Provisional; Region: PRK12516 158189007488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189007489 HAMP domain; Region: HAMP; pfam00672 158189007490 Histidine kinase; Region: His_kinase; pfam06580 158189007491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189007492 Mg2+ binding site [ion binding]; other site 158189007493 G-X-G motif; other site 158189007494 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 158189007495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189007496 active site 158189007497 phosphorylation site [posttranslational modification] 158189007498 intermolecular recognition site; other site 158189007499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189007500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189007501 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189007502 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189007503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189007504 dimer interface [polypeptide binding]; other site 158189007505 conserved gate region; other site 158189007506 putative PBP binding loops; other site 158189007507 ABC-ATPase subunit interface; other site 158189007508 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189007509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189007510 dimer interface [polypeptide binding]; other site 158189007511 conserved gate region; other site 158189007512 putative PBP binding loops; other site 158189007513 ABC-ATPase subunit interface; other site 158189007514 Transposase [DNA replication, recombination, and repair]; Region: COG5421 158189007515 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158189007516 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158189007517 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007518 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189007519 TM-ABC transporter signature motif; other site 158189007520 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189007521 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007522 TM-ABC transporter signature motif; other site 158189007523 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189007524 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189007525 Walker A/P-loop; other site 158189007526 ATP binding site [chemical binding]; other site 158189007527 Q-loop/lid; other site 158189007528 ABC transporter signature motif; other site 158189007529 Walker B; other site 158189007530 D-loop; other site 158189007531 H-loop/switch region; other site 158189007532 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189007533 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189007534 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189007535 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 158189007536 dimer interface [polypeptide binding]; other site 158189007537 metal binding site [ion binding]; metal-binding site 158189007538 substrate binding site [chemical binding]; other site 158189007539 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 158189007540 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 158189007541 substrate binding site [chemical binding]; other site 158189007542 metal binding site [ion binding]; metal-binding site 158189007543 dimer interface [polypeptide binding]; other site 158189007544 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158189007545 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158189007546 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158189007547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189007548 motif I; other site 158189007549 active site 158189007550 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 158189007551 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 158189007552 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 158189007553 N- and C-terminal domain interface [polypeptide binding]; other site 158189007554 putative active site [active] 158189007555 MgATP binding site [chemical binding]; other site 158189007556 catalytic site [active] 158189007557 metal binding site [ion binding]; metal-binding site 158189007558 putative xylulose binding site [chemical binding]; other site 158189007559 putative homodimer interface [polypeptide binding]; other site 158189007560 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 158189007561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 158189007562 motif II; other site 158189007563 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 158189007564 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189007565 active site 158189007566 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007567 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189007568 TM-ABC transporter signature motif; other site 158189007569 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007570 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189007571 TM-ABC transporter signature motif; other site 158189007572 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158189007573 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189007574 Walker A/P-loop; other site 158189007575 ATP binding site [chemical binding]; other site 158189007576 Q-loop/lid; other site 158189007577 ABC transporter signature motif; other site 158189007578 Walker B; other site 158189007579 D-loop; other site 158189007580 H-loop/switch region; other site 158189007581 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189007582 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 158189007583 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158189007584 ligand binding site [chemical binding]; other site 158189007585 BtpA family; Region: BtpA; cl00440 158189007586 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158189007587 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158189007588 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158189007589 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158189007590 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 158189007591 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 158189007592 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 158189007593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 158189007594 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189007595 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189007596 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189007597 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189007598 Walker A/P-loop; other site 158189007599 ATP binding site [chemical binding]; other site 158189007600 Q-loop/lid; other site 158189007601 ABC transporter signature motif; other site 158189007602 Walker B; other site 158189007603 D-loop; other site 158189007604 H-loop/switch region; other site 158189007605 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189007606 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007607 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189007608 TM-ABC transporter signature motif; other site 158189007609 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189007610 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007611 TM-ABC transporter signature motif; other site 158189007612 Response regulator receiver domain; Region: Response_reg; pfam00072 158189007613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189007614 active site 158189007615 phosphorylation site [posttranslational modification] 158189007616 intermolecular recognition site; other site 158189007617 dimerization interface [polypeptide binding]; other site 158189007618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189007619 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189007620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189007621 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 158189007622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158189007623 dimerization interface [polypeptide binding]; other site 158189007624 Histidine kinase; Region: His_kinase; pfam06580 158189007625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189007626 ATP binding site [chemical binding]; other site 158189007627 Mg2+ binding site [ion binding]; other site 158189007628 G-X-G motif; other site 158189007629 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 158189007630 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189007631 putative ligand binding site [chemical binding]; other site 158189007632 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 158189007633 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158189007634 ATP binding site [chemical binding]; other site 158189007635 Mg++ binding site [ion binding]; other site 158189007636 motif III; other site 158189007637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189007638 nucleotide binding region [chemical binding]; other site 158189007639 ATP-binding site [chemical binding]; other site 158189007640 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 158189007641 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 158189007642 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158189007643 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158189007644 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158189007645 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158189007646 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158189007647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189007648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189007649 Homeobox associated leucine zipper; Region: HALZ; cl02577 158189007650 putative transposase OrfB; Reviewed; Region: PHA02517 158189007651 HTH-like domain; Region: HTH_21; pfam13276 158189007652 Integrase core domain; Region: rve; pfam00665 158189007653 Integrase core domain; Region: rve_2; pfam13333 158189007654 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 158189007655 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 158189007656 active site 158189007657 homodimer interface [polypeptide binding]; other site 158189007658 catalytic site [active] 158189007659 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189007660 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189007661 DNA binding site [nucleotide binding] 158189007662 domain linker motif; other site 158189007663 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189007664 ligand binding site [chemical binding]; other site 158189007665 dimerization interface [polypeptide binding]; other site 158189007666 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189007667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189007668 dimer interface [polypeptide binding]; other site 158189007669 conserved gate region; other site 158189007670 putative PBP binding loops; other site 158189007671 ABC-ATPase subunit interface; other site 158189007672 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189007673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189007674 dimer interface [polypeptide binding]; other site 158189007675 conserved gate region; other site 158189007676 putative PBP binding loops; other site 158189007677 ABC-ATPase subunit interface; other site 158189007678 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189007679 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189007680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189007681 galactonate dehydratase; Provisional; Region: PRK14017 158189007682 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 158189007683 metal binding site [ion binding]; metal-binding site 158189007684 substrate binding pocket [chemical binding]; other site 158189007685 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 158189007686 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189007687 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158189007688 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158189007689 DctM-like transporters; Region: DctM; pfam06808 158189007690 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189007691 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 158189007692 classical (c) SDRs; Region: SDR_c; cd05233 158189007693 NAD(P) binding site [chemical binding]; other site 158189007694 active site 158189007695 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 158189007696 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 158189007697 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 158189007698 mannonate dehydratase; Region: uxuA; TIGR00695 158189007699 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158189007700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189007701 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189007702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189007703 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 158189007704 putative active cleft [active] 158189007705 dimerization interface [polypeptide binding]; other site 158189007706 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 158189007707 active site 158189007708 catalytic triad [active] 158189007709 oxyanion hole [active] 158189007710 Fic family protein [Function unknown]; Region: COG3177 158189007711 Fic/DOC family; Region: Fic; pfam02661 158189007712 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 158189007713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158189007714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158189007715 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158189007716 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 158189007717 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 158189007718 E3 interaction surface; other site 158189007719 lipoyl attachment site [posttranslational modification]; other site 158189007720 e3 binding domain; Region: E3_binding; pfam02817 158189007721 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 158189007722 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 158189007723 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 158189007724 dimer interface [polypeptide binding]; other site 158189007725 TPP-binding site [chemical binding]; other site 158189007726 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158189007727 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 158189007728 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189007729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189007730 non-specific DNA binding site [nucleotide binding]; other site 158189007731 salt bridge; other site 158189007732 sequence-specific DNA binding site [nucleotide binding]; other site 158189007733 Domain of unknown function (DUF955); Region: DUF955; pfam06114 158189007734 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 158189007735 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 158189007736 conserved cys residue [active] 158189007737 Predicted transcriptional regulator [Transcription]; Region: COG2378 158189007738 HTH domain; Region: HTH_11; pfam08279 158189007739 WYL domain; Region: WYL; pfam13280 158189007740 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158189007741 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 158189007742 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158189007743 nucleotide binding site [chemical binding]; other site 158189007744 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 158189007745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189007746 active site 158189007747 phosphorylation site [posttranslational modification] 158189007748 intermolecular recognition site; other site 158189007749 dimerization interface [polypeptide binding]; other site 158189007750 LytTr DNA-binding domain; Region: LytTR; smart00850 158189007751 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 158189007752 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 158189007753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189007754 active site 158189007755 phosphorylation site [posttranslational modification] 158189007756 intermolecular recognition site; other site 158189007757 dimerization interface [polypeptide binding]; other site 158189007758 LytTr DNA-binding domain; Region: LytTR; smart00850 158189007759 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 158189007760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158189007761 putative DNA binding site [nucleotide binding]; other site 158189007762 putative Zn2+ binding site [ion binding]; other site 158189007763 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189007764 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189007765 Walker A/P-loop; other site 158189007766 ATP binding site [chemical binding]; other site 158189007767 Q-loop/lid; other site 158189007768 ABC transporter signature motif; other site 158189007769 Walker B; other site 158189007770 D-loop; other site 158189007771 H-loop/switch region; other site 158189007772 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189007773 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158189007774 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189007775 TM-ABC transporter signature motif; other site 158189007776 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158189007777 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158189007778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189007779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189007780 DNA binding site [nucleotide binding] 158189007781 domain linker motif; other site 158189007782 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189007783 dimerization interface [polypeptide binding]; other site 158189007784 ligand binding site [chemical binding]; other site 158189007785 TIGR04255 family protein; Region: sporadTIGR04255 158189007786 Transposase; Region: HTH_Tnp_IS630; pfam01710 158189007787 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 158189007788 Beta-lactamase; Region: Beta-lactamase; pfam00144 158189007789 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 158189007790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189007791 Coenzyme A binding pocket [chemical binding]; other site 158189007792 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 158189007793 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 158189007794 metal binding site [ion binding]; metal-binding site 158189007795 substrate binding pocket [chemical binding]; other site 158189007796 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 158189007797 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158189007798 Walker A/P-loop; other site 158189007799 ATP binding site [chemical binding]; other site 158189007800 Q-loop/lid; other site 158189007801 ABC transporter signature motif; other site 158189007802 Walker B; other site 158189007803 D-loop; other site 158189007804 H-loop/switch region; other site 158189007805 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158189007806 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 158189007807 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158189007808 Walker A/P-loop; other site 158189007809 ATP binding site [chemical binding]; other site 158189007810 Q-loop/lid; other site 158189007811 ABC transporter signature motif; other site 158189007812 Walker B; other site 158189007813 D-loop; other site 158189007814 H-loop/switch region; other site 158189007815 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158189007816 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 158189007817 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 158189007818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189007819 dimer interface [polypeptide binding]; other site 158189007820 conserved gate region; other site 158189007821 putative PBP binding loops; other site 158189007822 ABC-ATPase subunit interface; other site 158189007823 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158189007824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189007825 dimer interface [polypeptide binding]; other site 158189007826 conserved gate region; other site 158189007827 putative PBP binding loops; other site 158189007828 ABC-ATPase subunit interface; other site 158189007829 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 158189007830 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 158189007831 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 158189007832 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 158189007833 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 158189007834 putative active site [active] 158189007835 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158189007836 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158189007837 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158189007838 putative active site [active] 158189007839 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 158189007840 PLD-like domain; Region: PLDc_2; pfam13091 158189007841 putative homodimer interface [polypeptide binding]; other site 158189007842 putative active site [active] 158189007843 catalytic site [active] 158189007844 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158189007845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189007846 ATP binding site [chemical binding]; other site 158189007847 putative Mg++ binding site [ion binding]; other site 158189007848 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 158189007849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189007850 nucleotide binding region [chemical binding]; other site 158189007851 ATP-binding site [chemical binding]; other site 158189007852 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 158189007853 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 158189007854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189007855 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 158189007856 DNA-binding site [nucleotide binding]; DNA binding site 158189007857 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 158189007858 Cupin domain; Region: Cupin_2; pfam07883 158189007859 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189007860 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158189007861 DctM-like transporters; Region: DctM; pfam06808 158189007862 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189007863 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 158189007864 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189007865 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189007866 metal binding site [ion binding]; metal-binding site 158189007867 active site 158189007868 I-site; other site 158189007869 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 158189007870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158189007871 dimerization interface [polypeptide binding]; other site 158189007872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189007873 PAS domain; Region: PAS_9; pfam13426 158189007874 putative active site [active] 158189007875 heme pocket [chemical binding]; other site 158189007876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189007877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189007878 metal binding site [ion binding]; metal-binding site 158189007879 active site 158189007880 I-site; other site 158189007881 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189007882 Zn2+ binding site [ion binding]; other site 158189007883 Mg2+ binding site [ion binding]; other site 158189007884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189007885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189007886 FMN-binding domain; Region: FMN_bind; cl01081 158189007887 TfoX N-terminal domain; Region: TfoX_N; cl17592 158189007888 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158189007889 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158189007890 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 158189007891 Aspartase; Region: Aspartase; cd01357 158189007892 active sites [active] 158189007893 tetramer interface [polypeptide binding]; other site 158189007894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189007895 non-specific DNA binding site [nucleotide binding]; other site 158189007896 salt bridge; other site 158189007897 sequence-specific DNA binding site [nucleotide binding]; other site 158189007898 FMN-binding domain; Region: FMN_bind; cl01081 158189007899 ApbE family; Region: ApbE; pfam02424 158189007900 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 158189007901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189007902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189007903 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 158189007904 putative active site pocket [active] 158189007905 dimerization interface [polypeptide binding]; other site 158189007906 putative catalytic residue [active] 158189007907 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 158189007908 putative substrate binding pocket [chemical binding]; other site 158189007909 AC domain interface; other site 158189007910 catalytic triad [active] 158189007911 AB domain interface; other site 158189007912 interchain disulfide; other site 158189007913 Predicted membrane protein [Function unknown]; Region: COG3817 158189007914 Protein of unknown function (DUF979); Region: DUF979; pfam06166 158189007915 Protein of unknown function (DUF969); Region: DUF969; pfam06149 158189007916 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189007917 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189007918 metal binding site [ion binding]; metal-binding site 158189007919 active site 158189007920 I-site; other site 158189007921 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 158189007922 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 158189007923 NAD binding site [chemical binding]; other site 158189007924 ligand binding site [chemical binding]; other site 158189007925 catalytic site [active] 158189007926 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 158189007927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189007928 active site 158189007929 phosphorylation site [posttranslational modification] 158189007930 intermolecular recognition site; other site 158189007931 dimerization interface [polypeptide binding]; other site 158189007932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189007933 Zn2+ binding site [ion binding]; other site 158189007934 Mg2+ binding site [ion binding]; other site 158189007935 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158189007936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158189007937 substrate binding pocket [chemical binding]; other site 158189007938 membrane-bound complex binding site; other site 158189007939 hinge residues; other site 158189007940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158189007941 dimer interface [polypeptide binding]; other site 158189007942 phosphorylation site [posttranslational modification] 158189007943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189007944 ATP binding site [chemical binding]; other site 158189007945 Mg2+ binding site [ion binding]; other site 158189007946 G-X-G motif; other site 158189007947 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 158189007948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189007949 active site 158189007950 phosphorylation site [posttranslational modification] 158189007951 intermolecular recognition site; other site 158189007952 dimerization interface [polypeptide binding]; other site 158189007953 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 158189007954 putative binding surface; other site 158189007955 active site 158189007956 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 158189007957 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 158189007958 catalytic site [active] 158189007959 LCCL domain; Region: LCCL; cl02694 158189007960 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158189007961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189007962 DNA-binding site [nucleotide binding]; DNA binding site 158189007963 FCD domain; Region: FCD; pfam07729 158189007964 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189007965 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158189007966 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 158189007967 DctM-like transporters; Region: DctM; pfam06808 158189007968 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 158189007969 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158189007970 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158189007971 DNA interaction; other site 158189007972 Metal-binding active site; metal-binding site 158189007973 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 158189007974 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189007975 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 158189007976 active site 158189007977 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 158189007978 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 158189007979 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 158189007980 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189007981 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158189007982 active site 158189007983 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 158189007984 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 158189007985 active site 158189007986 Zn binding site [ion binding]; other site 158189007987 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 158189007988 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158189007989 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158189007990 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 158189007991 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 158189007992 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 158189007993 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 158189007994 catalytic loop [active] 158189007995 iron binding site [ion binding]; other site 158189007996 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158189007997 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158189007998 metal-binding site [ion binding] 158189007999 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 158189008000 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158189008001 Soluble P-type ATPase [General function prediction only]; Region: COG4087 158189008002 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 158189008003 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 158189008004 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 158189008005 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 158189008006 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 158189008007 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 158189008008 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158189008009 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 158189008010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189008011 Coenzyme A binding pocket [chemical binding]; other site 158189008012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189008013 Coenzyme A binding pocket [chemical binding]; other site 158189008014 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158189008015 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 158189008016 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158189008017 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 158189008018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158189008019 FeS/SAM binding site; other site 158189008020 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 158189008021 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 158189008022 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 158189008023 Mechanosensitive ion channel; Region: MS_channel; pfam00924 158189008024 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 158189008025 OPT oligopeptide transporter protein; Region: OPT; cl14607 158189008026 PAS domain; Region: PAS; smart00091 158189008027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189008028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158189008029 dimer interface [polypeptide binding]; other site 158189008030 phosphorylation site [posttranslational modification] 158189008031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189008032 ATP binding site [chemical binding]; other site 158189008033 Mg2+ binding site [ion binding]; other site 158189008034 G-X-G motif; other site 158189008035 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158189008036 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 158189008037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189008038 active site 158189008039 phosphorylation site [posttranslational modification] 158189008040 intermolecular recognition site; other site 158189008041 dimerization interface [polypeptide binding]; other site 158189008042 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189008043 Zn2+ binding site [ion binding]; other site 158189008044 Mg2+ binding site [ion binding]; other site 158189008045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189008046 S-adenosylmethionine binding site [chemical binding]; other site 158189008047 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 158189008048 TIGR02452 family protein; Region: TIGR02452 158189008049 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 158189008050 putative ADP-ribose binding site [chemical binding]; other site 158189008051 putative active site [active] 158189008052 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 158189008053 metal ion-dependent adhesion site (MIDAS); other site 158189008054 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 158189008055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 158189008056 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 158189008057 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 158189008058 Walker A/P-loop; other site 158189008059 ATP binding site [chemical binding]; other site 158189008060 Q-loop/lid; other site 158189008061 ABC transporter signature motif; other site 158189008062 Walker B; other site 158189008063 D-loop; other site 158189008064 H-loop/switch region; other site 158189008065 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 158189008066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189008067 dimer interface [polypeptide binding]; other site 158189008068 conserved gate region; other site 158189008069 putative PBP binding loops; other site 158189008070 ABC-ATPase subunit interface; other site 158189008071 Predicted flavoprotein [General function prediction only]; Region: COG0431 158189008072 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158189008073 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 158189008074 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 158189008075 Cupin domain; Region: Cupin_2; cl17218 158189008076 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 158189008077 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 158189008078 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158189008079 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158189008080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 158189008081 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158189008082 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 158189008083 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 158189008084 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 158189008085 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158189008086 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189008087 DNA-binding site [nucleotide binding]; DNA binding site 158189008088 FCD domain; Region: FCD; pfam07729 158189008089 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 158189008090 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 158189008091 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 158189008092 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 158189008093 active site 158189008094 Putative cyclase; Region: Cyclase; cl00814 158189008095 membrane protein FdrA; Validated; Region: PRK06091 158189008096 CoA binding domain; Region: CoA_binding; pfam02629 158189008097 CoA-ligase; Region: Ligase_CoA; pfam00549 158189008098 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 158189008099 RES domain; Region: RES; pfam08808 158189008100 HNH endonuclease; Region: HNH_2; pfam13391 158189008101 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 158189008102 Uncharacterized conserved protein [Function unknown]; Region: COG3410 158189008103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189008104 non-specific DNA binding site [nucleotide binding]; other site 158189008105 salt bridge; other site 158189008106 sequence-specific DNA binding site [nucleotide binding]; other site 158189008107 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 158189008108 homodimer interface [polypeptide binding]; other site 158189008109 chemical substrate binding site [chemical binding]; other site 158189008110 oligomer interface [polypeptide binding]; other site 158189008111 metal binding site [ion binding]; metal-binding site 158189008112 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 158189008113 putative active site [active] 158189008114 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 158189008115 putative active site [active] 158189008116 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 158189008117 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 158189008118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189008119 ATP binding site [chemical binding]; other site 158189008120 putative Mg++ binding site [ion binding]; other site 158189008121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189008122 nucleotide binding region [chemical binding]; other site 158189008123 ATP-binding site [chemical binding]; other site 158189008124 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 158189008125 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 158189008126 cofactor binding site; other site 158189008127 DNA binding site [nucleotide binding] 158189008128 substrate interaction site [chemical binding]; other site 158189008129 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 158189008130 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 158189008131 active site 158189008132 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 158189008133 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 158189008134 diiron binding motif [ion binding]; other site 158189008135 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189008136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189008137 ligand binding site [chemical binding]; other site 158189008138 dimerization interface [polypeptide binding]; other site 158189008139 Helix-turn-helix domain; Region: HTH_18; pfam12833 158189008140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189008141 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189008142 Abhydrolase family; Region: Abhydrolase_7; pfam12715 158189008143 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 158189008144 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 158189008145 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 158189008146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158189008147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158189008148 DNA binding residues [nucleotide binding] 158189008149 dimerization interface [polypeptide binding]; other site 158189008150 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 158189008151 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 158189008152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189008153 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158189008154 non-specific DNA binding site [nucleotide binding]; other site 158189008155 salt bridge; other site 158189008156 sequence-specific DNA binding site [nucleotide binding]; other site 158189008157 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 158189008158 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 158189008159 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 158189008160 NAD(P) binding site [chemical binding]; other site 158189008161 LDH/MDH dimer interface [polypeptide binding]; other site 158189008162 substrate binding site [chemical binding]; other site 158189008163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189008164 Response regulator receiver domain; Region: Response_reg; pfam00072 158189008165 active site 158189008166 phosphorylation site [posttranslational modification] 158189008167 intermolecular recognition site; other site 158189008168 dimerization interface [polypeptide binding]; other site 158189008169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189008170 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189008171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189008172 Histidine kinase; Region: His_kinase; pfam06580 158189008173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189008174 ATP binding site [chemical binding]; other site 158189008175 Mg2+ binding site [ion binding]; other site 158189008176 G-X-G motif; other site 158189008177 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189008178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189008179 dimer interface [polypeptide binding]; other site 158189008180 conserved gate region; other site 158189008181 putative PBP binding loops; other site 158189008182 ABC-ATPase subunit interface; other site 158189008183 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189008184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189008185 dimer interface [polypeptide binding]; other site 158189008186 conserved gate region; other site 158189008187 putative PBP binding loops; other site 158189008188 ABC-ATPase subunit interface; other site 158189008189 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189008190 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158189008191 Amidohydrolase; Region: Amidohydro_2; pfam04909 158189008192 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 158189008193 RloB-like protein; Region: RloB; pfam13707 158189008194 CAAX protease self-immunity; Region: Abi; pfam02517 158189008195 Protein of unknown function (DUF523); Region: DUF523; pfam04463 158189008196 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 158189008197 YibE/F-like protein; Region: YibE_F; pfam07907 158189008198 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 158189008199 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 158189008200 dimer interface [polypeptide binding]; other site 158189008201 active site 158189008202 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 158189008203 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 158189008204 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 158189008205 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 158189008206 active site 158189008207 catalytic residues [active] 158189008208 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 158189008209 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 158189008210 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 158189008211 Response regulator receiver domain; Region: Response_reg; pfam00072 158189008212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189008213 active site 158189008214 phosphorylation site [posttranslational modification] 158189008215 intermolecular recognition site; other site 158189008216 dimerization interface [polypeptide binding]; other site 158189008217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189008218 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189008219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189008220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158189008221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158189008222 dimerization interface [polypeptide binding]; other site 158189008223 Histidine kinase; Region: His_kinase; pfam06580 158189008224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189008225 ATP binding site [chemical binding]; other site 158189008226 Mg2+ binding site [ion binding]; other site 158189008227 G-X-G motif; other site 158189008228 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 158189008229 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 158189008230 active site 158189008231 dimerization interface [polypeptide binding]; other site 158189008232 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158189008233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189008234 dimer interface [polypeptide binding]; other site 158189008235 conserved gate region; other site 158189008236 putative PBP binding loops; other site 158189008237 ABC-ATPase subunit interface; other site 158189008238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189008239 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 158189008240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189008241 dimer interface [polypeptide binding]; other site 158189008242 conserved gate region; other site 158189008243 putative PBP binding loops; other site 158189008244 ABC-ATPase subunit interface; other site 158189008245 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158189008246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189008247 Walker A/P-loop; other site 158189008248 ATP binding site [chemical binding]; other site 158189008249 Q-loop/lid; other site 158189008250 ABC transporter signature motif; other site 158189008251 Walker B; other site 158189008252 D-loop; other site 158189008253 H-loop/switch region; other site 158189008254 TOBE domain; Region: TOBE_2; pfam08402 158189008255 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158189008256 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189008257 hypothetical protein; Provisional; Region: PRK09272 158189008258 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189008259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189008260 metal binding site [ion binding]; metal-binding site 158189008261 active site 158189008262 I-site; other site 158189008263 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158189008264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 158189008265 Transposase; Region: DDE_Tnp_ISL3; pfam01610 158189008266 Methyltransferase domain; Region: Methyltransf_23; pfam13489 158189008267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189008268 S-adenosylmethionine binding site [chemical binding]; other site 158189008269 transketolase; Reviewed; Region: PRK12753 158189008270 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158189008271 TPP-binding site [chemical binding]; other site 158189008272 dimer interface [polypeptide binding]; other site 158189008273 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158189008274 PYR/PP interface [polypeptide binding]; other site 158189008275 dimer interface [polypeptide binding]; other site 158189008276 TPP binding site [chemical binding]; other site 158189008277 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158189008278 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158189008279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189008280 DNA-binding site [nucleotide binding]; DNA binding site 158189008281 FCD domain; Region: FCD; pfam07729 158189008282 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 158189008283 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 158189008284 active site 158189008285 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 158189008286 tartrate dehydrogenase; Provisional; Region: PRK08194 158189008287 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189008288 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158189008289 DctM-like transporters; Region: DctM; pfam06808 158189008290 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189008291 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158189008292 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158189008293 active site 158189008294 phosphorylation site [posttranslational modification] 158189008295 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 158189008296 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 158189008297 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 158189008298 active site 158189008299 catalytic triad [active] 158189008300 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158189008301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189008302 active site 158189008303 phosphorylation site [posttranslational modification] 158189008304 intermolecular recognition site; other site 158189008305 dimerization interface [polypeptide binding]; other site 158189008306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158189008307 DNA binding residues [nucleotide binding] 158189008308 dimerization interface [polypeptide binding]; other site 158189008309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 158189008310 Histidine kinase; Region: HisKA_3; pfam07730 158189008311 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 158189008312 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158189008313 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158189008314 Walker A/P-loop; other site 158189008315 ATP binding site [chemical binding]; other site 158189008316 Q-loop/lid; other site 158189008317 ABC transporter signature motif; other site 158189008318 Walker B; other site 158189008319 D-loop; other site 158189008320 H-loop/switch region; other site 158189008321 OsmC-like protein; Region: OsmC; cl00767 158189008322 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 158189008323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158189008324 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189008325 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189008326 metal binding site [ion binding]; metal-binding site 158189008327 active site 158189008328 I-site; other site 158189008329 Response regulator receiver domain; Region: Response_reg; pfam00072 158189008330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158189008331 active site 158189008332 phosphorylation site [posttranslational modification] 158189008333 intermolecular recognition site; other site 158189008334 dimerization interface [polypeptide binding]; other site 158189008335 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 158189008336 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 158189008337 DXD motif; other site 158189008338 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 158189008339 active site 158189008340 catalytic residues [active] 158189008341 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 158189008342 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 158189008343 putative active site [active] 158189008344 putative metal binding site [ion binding]; other site 158189008345 Protein of unknown function (DUF422); Region: DUF422; cl00991 158189008346 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 158189008347 active site lid residues [active] 158189008348 substrate binding pocket [chemical binding]; other site 158189008349 catalytic residues [active] 158189008350 substrate-Mg2+ binding site; other site 158189008351 aspartate-rich region 1; other site 158189008352 aspartate-rich region 2; other site 158189008353 phytoene desaturase; Region: crtI_fam; TIGR02734 158189008354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158189008355 Domain of unknown function (DUF386); Region: DUF386; cl01047 158189008356 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 158189008357 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158189008358 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 158189008359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158189008360 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 158189008361 active site 158189008362 metal binding site [ion binding]; metal-binding site 158189008363 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 158189008364 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 158189008365 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 158189008366 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 158189008367 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158189008368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158189008369 Propionate catabolism activator; Region: PrpR_N; pfam06506 158189008370 PAS domain; Region: PAS; smart00091 158189008371 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 158189008372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189008373 Walker A motif; other site 158189008374 ATP binding site [chemical binding]; other site 158189008375 Walker B motif; other site 158189008376 arginine finger; other site 158189008377 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 158189008378 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158189008379 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158189008380 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158189008381 DctM-like transporters; Region: DctM; pfam06808 158189008382 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158189008383 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158189008384 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158189008385 inhibitor site; inhibition site 158189008386 active site 158189008387 dimer interface [polypeptide binding]; other site 158189008388 catalytic residue [active] 158189008389 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 158189008390 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158189008391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189008392 DNA-binding site [nucleotide binding]; DNA binding site 158189008393 FCD domain; Region: FCD; pfam07729 158189008394 B12 binding domain; Region: B12-binding_2; pfam02607 158189008395 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 158189008396 B12 binding domain; Region: B12-binding; pfam02310 158189008397 B12 binding site [chemical binding]; other site 158189008398 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189008399 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189008400 metal binding site [ion binding]; metal-binding site 158189008401 active site 158189008402 I-site; other site 158189008403 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 158189008404 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 158189008405 DNA binding residues [nucleotide binding] 158189008406 dimer interface [polypeptide binding]; other site 158189008407 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 158189008408 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 158189008409 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 158189008410 Nitrogen regulatory protein P-II; Region: P-II; smart00938 158189008411 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 158189008412 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189008413 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189008414 active site 158189008415 catalytic tetrad [active] 158189008416 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 158189008417 peptidase T-like protein; Region: PepT-like; TIGR01883 158189008418 metal binding site [ion binding]; metal-binding site 158189008419 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 158189008420 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 158189008421 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 158189008422 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 158189008423 active site 158189008424 catalytic site [active] 158189008425 substrate binding site [chemical binding]; other site 158189008426 HRDC domain; Region: HRDC; cl02578 158189008427 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 158189008428 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 158189008429 putative active site [active] 158189008430 metal binding site [ion binding]; metal-binding site 158189008431 uracil transporter; Provisional; Region: PRK10720 158189008432 Predicted transcriptional regulator [Transcription]; Region: COG2378 158189008433 WYL domain; Region: WYL; pfam13280 158189008434 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 158189008435 active site 158189008436 substrate-binding site [chemical binding]; other site 158189008437 metal-binding site [ion binding] 158189008438 GTP binding site [chemical binding]; other site 158189008439 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158189008440 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158189008441 ligand binding site [chemical binding]; other site 158189008442 flexible hinge region; other site 158189008443 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 158189008444 Peptidase family U32; Region: Peptidase_U32; pfam01136 158189008445 Collagenase; Region: DUF3656; pfam12392 158189008446 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 158189008447 nudix motif; other site 158189008448 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 158189008449 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 158189008450 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 158189008451 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 158189008452 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 158189008453 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 158189008454 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 158189008455 PBP superfamily domain; Region: PBP_like_2; cl17296 158189008456 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158189008457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189008458 dimer interface [polypeptide binding]; other site 158189008459 conserved gate region; other site 158189008460 putative PBP binding loops; other site 158189008461 ABC-ATPase subunit interface; other site 158189008462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189008463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189008464 dimer interface [polypeptide binding]; other site 158189008465 conserved gate region; other site 158189008466 putative PBP binding loops; other site 158189008467 ABC-ATPase subunit interface; other site 158189008468 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 158189008469 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 158189008470 NAD(P) binding site [chemical binding]; other site 158189008471 LDH/MDH dimer interface [polypeptide binding]; other site 158189008472 substrate binding site [chemical binding]; other site 158189008473 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189008474 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189008475 DNA binding site [nucleotide binding] 158189008476 domain linker motif; other site 158189008477 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189008478 dimerization interface [polypeptide binding]; other site 158189008479 ligand binding site [chemical binding]; other site 158189008480 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158189008481 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158189008482 substrate binding pocket [chemical binding]; other site 158189008483 membrane-bound complex binding site; other site 158189008484 hinge residues; other site 158189008485 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 158189008486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189008487 dimer interface [polypeptide binding]; other site 158189008488 conserved gate region; other site 158189008489 putative PBP binding loops; other site 158189008490 ABC-ATPase subunit interface; other site 158189008491 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158189008492 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158189008493 Walker A/P-loop; other site 158189008494 ATP binding site [chemical binding]; other site 158189008495 Q-loop/lid; other site 158189008496 ABC transporter signature motif; other site 158189008497 Walker B; other site 158189008498 D-loop; other site 158189008499 H-loop/switch region; other site 158189008500 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189008501 metal binding site [ion binding]; metal-binding site 158189008502 active site 158189008503 I-site; other site 158189008504 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158189008505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 158189008506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 158189008507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 158189008508 dimerization interface [polypeptide binding]; other site 158189008509 EamA-like transporter family; Region: EamA; pfam00892 158189008510 EamA-like transporter family; Region: EamA; pfam00892 158189008511 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 158189008512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189008513 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 158189008514 putative active site [active] 158189008515 heme pocket [chemical binding]; other site 158189008516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189008517 putative active site [active] 158189008518 heme pocket [chemical binding]; other site 158189008519 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189008520 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189008521 metal binding site [ion binding]; metal-binding site 158189008522 active site 158189008523 I-site; other site 158189008524 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158189008525 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 158189008526 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 158189008527 active site 158189008528 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 158189008529 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 158189008530 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158189008531 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 158189008532 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 158189008533 KDPG and KHG aldolase; Region: Aldolase; cl17259 158189008534 Protein of unknown function (DUF523); Region: DUF523; pfam04463 158189008535 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158189008536 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 158189008537 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 158189008538 homodimer interaction site [polypeptide binding]; other site 158189008539 cofactor binding site; other site 158189008540 Creatinine amidohydrolase; Region: Creatininase; pfam02633 158189008541 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189008542 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189008543 metal binding site [ion binding]; metal-binding site 158189008544 active site 158189008545 I-site; other site 158189008546 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 158189008547 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158189008548 active site 158189008549 LabA_like proteins; Region: LabA_like; cd06167 158189008550 putative metal binding site [ion binding]; other site 158189008551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189008552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189008553 metal binding site [ion binding]; metal-binding site 158189008554 active site 158189008555 I-site; other site 158189008556 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 158189008557 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 158189008558 domain interfaces; other site 158189008559 active site 158189008560 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 158189008561 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 158189008562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158189008563 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158189008564 DNA binding residues [nucleotide binding] 158189008565 dimerization interface [polypeptide binding]; other site 158189008566 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 158189008567 metal binding site 2 [ion binding]; metal-binding site 158189008568 putative DNA binding helix; other site 158189008569 metal binding site 1 [ion binding]; metal-binding site 158189008570 dimer interface [polypeptide binding]; other site 158189008571 structural Zn2+ binding site [ion binding]; other site 158189008572 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 158189008573 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158189008574 ABC-ATPase subunit interface; other site 158189008575 dimer interface [polypeptide binding]; other site 158189008576 putative PBP binding regions; other site 158189008577 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158189008578 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 158189008579 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 158189008580 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 158189008581 intersubunit interface [polypeptide binding]; other site 158189008582 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 158189008583 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 158189008584 trimer interface [polypeptide binding]; other site 158189008585 putative metal binding site [ion binding]; other site 158189008586 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 158189008587 TrkA-N domain; Region: TrkA_N; pfam02254 158189008588 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 158189008589 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 158189008590 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 158189008591 Ferritin-like domain; Region: Ferritin; pfam00210 158189008592 ferroxidase diiron center [ion binding]; other site 158189008593 Pirin-related protein [General function prediction only]; Region: COG1741 158189008594 Pirin; Region: Pirin; pfam02678 158189008595 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 158189008596 Predicted transcriptional regulators [Transcription]; Region: COG1725 158189008597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189008598 DNA-binding site [nucleotide binding]; DNA binding site 158189008599 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 158189008600 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 158189008601 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158189008602 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158189008603 Walker A/P-loop; other site 158189008604 ATP binding site [chemical binding]; other site 158189008605 Q-loop/lid; other site 158189008606 ABC transporter signature motif; other site 158189008607 Walker B; other site 158189008608 D-loop; other site 158189008609 H-loop/switch region; other site 158189008610 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158189008611 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158189008612 FtsX-like permease family; Region: FtsX; pfam02687 158189008613 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158189008614 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158189008615 FtsX-like permease family; Region: FtsX; pfam02687 158189008616 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 158189008617 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 158189008618 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189008619 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158189008620 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158189008621 ligand binding site [chemical binding]; other site 158189008622 flexible hinge region; other site 158189008623 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 158189008624 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 158189008625 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 158189008626 monoglyceride lipase; Provisional; Region: PHA02857 158189008627 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158189008628 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158189008629 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 158189008630 active site 158189008631 metal binding site [ion binding]; metal-binding site 158189008632 homotetramer interface [polypeptide binding]; other site 158189008633 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 158189008634 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 158189008635 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 158189008636 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 158189008637 active site 158189008638 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 158189008639 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 158189008640 trimerization site [polypeptide binding]; other site 158189008641 active site 158189008642 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 158189008643 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 158189008644 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 158189008645 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158189008646 catalytic residue [active] 158189008647 Flagellin N-methylase; Region: FliB; cl00497 158189008648 Survival protein SurE; Region: SurE; pfam01975 158189008649 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 158189008650 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 158189008651 transcription termination factor Rho; Provisional; Region: rho; PRK09376 158189008652 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 158189008653 RNA binding site [nucleotide binding]; other site 158189008654 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 158189008655 multimer interface [polypeptide binding]; other site 158189008656 Walker A motif; other site 158189008657 ATP binding site [chemical binding]; other site 158189008658 Walker B motif; other site 158189008659 competence damage-inducible protein A; Provisional; Region: PRK00549 158189008660 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 158189008661 putative MPT binding site; other site 158189008662 Competence-damaged protein; Region: CinA; cl00666 158189008663 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 158189008664 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 158189008665 putative active site [active] 158189008666 catalytic triad [active] 158189008667 putative dimer interface [polypeptide binding]; other site 158189008668 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 158189008669 IHF - DNA interface [nucleotide binding]; other site 158189008670 IHF dimer interface [polypeptide binding]; other site 158189008671 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 158189008672 PSP1 C-terminal conserved region; Region: PSP1; cl00770 158189008673 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 158189008674 active site 158189008675 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 158189008676 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 158189008677 FMN binding site [chemical binding]; other site 158189008678 active site 158189008679 catalytic residues [active] 158189008680 substrate binding site [chemical binding]; other site 158189008681 phosphoribosylamine--glycine ligase; Region: purD; TIGR00877 158189008682 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 158189008683 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158189008684 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 158189008685 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189008686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189008687 metal binding site [ion binding]; metal-binding site 158189008688 active site 158189008689 I-site; other site 158189008690 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158189008691 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 158189008692 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189008693 TM-ABC transporter signature motif; other site 158189008694 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 158189008695 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189008696 TM-ABC transporter signature motif; other site 158189008697 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158189008698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189008699 Walker A/P-loop; other site 158189008700 ATP binding site [chemical binding]; other site 158189008701 Q-loop/lid; other site 158189008702 ABC transporter signature motif; other site 158189008703 Walker B; other site 158189008704 D-loop; other site 158189008705 H-loop/switch region; other site 158189008706 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189008707 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 158189008708 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189008709 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 158189008710 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 158189008711 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 158189008712 chaperone protein DnaJ; Provisional; Region: PRK10767 158189008713 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 158189008714 HSP70 interaction site [polypeptide binding]; other site 158189008715 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 158189008716 substrate binding site [polypeptide binding]; other site 158189008717 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 158189008718 Zn binding sites [ion binding]; other site 158189008719 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 158189008720 dimer interface [polypeptide binding]; other site 158189008721 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 158189008722 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 158189008723 nucleotide binding site [chemical binding]; other site 158189008724 NEF interaction site [polypeptide binding]; other site 158189008725 SBD interface [polypeptide binding]; other site 158189008726 GrpE; Region: GrpE; pfam01025 158189008727 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 158189008728 dimer interface [polypeptide binding]; other site 158189008729 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 158189008730 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 158189008731 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 158189008732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 158189008733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158189008734 motif II; other site 158189008735 GTP-binding protein Der; Reviewed; Region: PRK00093 158189008736 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 158189008737 G1 box; other site 158189008738 GTP/Mg2+ binding site [chemical binding]; other site 158189008739 Switch I region; other site 158189008740 G2 box; other site 158189008741 Switch II region; other site 158189008742 G3 box; other site 158189008743 G4 box; other site 158189008744 G5 box; other site 158189008745 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 158189008746 G1 box; other site 158189008747 GTP/Mg2+ binding site [chemical binding]; other site 158189008748 Switch I region; other site 158189008749 G2 box; other site 158189008750 G3 box; other site 158189008751 Switch II region; other site 158189008752 G4 box; other site 158189008753 G5 box; other site 158189008754 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 158189008755 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 158189008756 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 158189008757 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 158189008758 Sporulation and spore germination; Region: Germane; smart00909 158189008759 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 158189008760 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 158189008761 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 158189008762 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158189008763 putative active site [active] 158189008764 metal binding site [ion binding]; metal-binding site 158189008765 homodimer binding site [polypeptide binding]; other site 158189008766 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 158189008767 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 158189008768 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158189008769 Zn2+ binding site [ion binding]; other site 158189008770 Mg2+ binding site [ion binding]; other site 158189008771 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 158189008772 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 158189008773 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 158189008774 alphaNTD - beta interaction site [polypeptide binding]; other site 158189008775 alphaNTD homodimer interface [polypeptide binding]; other site 158189008776 alphaNTD - beta' interaction site [polypeptide binding]; other site 158189008777 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 158189008778 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 158189008779 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 158189008780 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158189008781 RNA binding surface [nucleotide binding]; other site 158189008782 30S ribosomal protein S11; Validated; Region: PRK05309 158189008783 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 158189008784 30S ribosomal protein S13; Region: bact_S13; TIGR03631 158189008785 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 158189008786 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 158189008787 SecY translocase; Region: SecY; pfam00344 158189008788 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 158189008789 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 158189008790 23S rRNA binding site [nucleotide binding]; other site 158189008791 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 158189008792 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 158189008793 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 158189008794 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 158189008795 23S rRNA interface [nucleotide binding]; other site 158189008796 L21e interface [polypeptide binding]; other site 158189008797 5S rRNA interface [nucleotide binding]; other site 158189008798 L27 interface [polypeptide binding]; other site 158189008799 L5 interface [polypeptide binding]; other site 158189008800 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 158189008801 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 158189008802 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 158189008803 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 158189008804 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 158189008805 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 158189008806 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 158189008807 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 158189008808 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 158189008809 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 158189008810 RNA binding site [nucleotide binding]; other site 158189008811 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 158189008812 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 158189008813 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 158189008814 putative translocon interaction site; other site 158189008815 signal recognition particle (SRP54) interaction site; other site 158189008816 L23 interface [polypeptide binding]; other site 158189008817 trigger factor interaction site; other site 158189008818 23S rRNA interface [nucleotide binding]; other site 158189008819 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 158189008820 23S rRNA interface [nucleotide binding]; other site 158189008821 5S rRNA interface [nucleotide binding]; other site 158189008822 putative antibiotic binding site [chemical binding]; other site 158189008823 L25 interface [polypeptide binding]; other site 158189008824 L27 interface [polypeptide binding]; other site 158189008825 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 158189008826 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 158189008827 G-X-X-G motif; other site 158189008828 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 158189008829 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 158189008830 putative translocon binding site; other site 158189008831 protein-rRNA interface [nucleotide binding]; other site 158189008832 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 158189008833 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 158189008834 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 158189008835 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 158189008836 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 158189008837 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 158189008838 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 158189008839 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 158189008840 elongation factor Tu; Reviewed; Region: PRK00049 158189008841 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 158189008842 G1 box; other site 158189008843 GEF interaction site [polypeptide binding]; other site 158189008844 GTP/Mg2+ binding site [chemical binding]; other site 158189008845 Switch I region; other site 158189008846 G2 box; other site 158189008847 G3 box; other site 158189008848 Switch II region; other site 158189008849 G4 box; other site 158189008850 G5 box; other site 158189008851 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 158189008852 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 158189008853 Antibiotic Binding Site [chemical binding]; other site 158189008854 30S ribosomal protein S7; Validated; Region: PRK05302 158189008855 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 158189008856 S17 interaction site [polypeptide binding]; other site 158189008857 S8 interaction site; other site 158189008858 16S rRNA interaction site [nucleotide binding]; other site 158189008859 streptomycin interaction site [chemical binding]; other site 158189008860 23S rRNA interaction site [nucleotide binding]; other site 158189008861 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 158189008862 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 158189008863 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 158189008864 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 158189008865 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 158189008866 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 158189008867 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 158189008868 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 158189008869 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 158189008870 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 158189008871 DNA binding site [nucleotide binding] 158189008872 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 158189008873 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 158189008874 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 158189008875 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 158189008876 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 158189008877 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 158189008878 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 158189008879 RPB10 interaction site [polypeptide binding]; other site 158189008880 RPB1 interaction site [polypeptide binding]; other site 158189008881 RPB11 interaction site [polypeptide binding]; other site 158189008882 RPB3 interaction site [polypeptide binding]; other site 158189008883 RPB12 interaction site [polypeptide binding]; other site 158189008884 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 158189008885 core dimer interface [polypeptide binding]; other site 158189008886 peripheral dimer interface [polypeptide binding]; other site 158189008887 L10 interface [polypeptide binding]; other site 158189008888 L11 interface [polypeptide binding]; other site 158189008889 putative EF-Tu interaction site [polypeptide binding]; other site 158189008890 putative EF-G interaction site [polypeptide binding]; other site 158189008891 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 158189008892 23S rRNA interface [nucleotide binding]; other site 158189008893 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 158189008894 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 158189008895 mRNA/rRNA interface [nucleotide binding]; other site 158189008896 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 158189008897 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 158189008898 23S rRNA interface [nucleotide binding]; other site 158189008899 L7/L12 interface [polypeptide binding]; other site 158189008900 putative thiostrepton binding site; other site 158189008901 L25 interface [polypeptide binding]; other site 158189008902 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 158189008903 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 158189008904 putative homodimer interface [polypeptide binding]; other site 158189008905 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 158189008906 heterodimer interface [polypeptide binding]; other site 158189008907 homodimer interface [polypeptide binding]; other site 158189008908 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 158189008909 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 158189008910 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 158189008911 homodimer interface [polypeptide binding]; other site 158189008912 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 158189008913 active site pocket [active] 158189008914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158189008915 non-specific DNA binding site [nucleotide binding]; other site 158189008916 salt bridge; other site 158189008917 sequence-specific DNA binding site [nucleotide binding]; other site 158189008918 Protein of unknown function (DUF554); Region: DUF554; pfam04474 158189008919 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 158189008920 Ligand binding site; other site 158189008921 metal-binding site 158189008922 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 158189008923 Clp amino terminal domain; Region: Clp_N; pfam02861 158189008924 Clp amino terminal domain; Region: Clp_N; pfam02861 158189008925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189008926 Walker A motif; other site 158189008927 ATP binding site [chemical binding]; other site 158189008928 Walker B motif; other site 158189008929 arginine finger; other site 158189008930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189008931 Walker A motif; other site 158189008932 ATP binding site [chemical binding]; other site 158189008933 Walker B motif; other site 158189008934 arginine finger; other site 158189008935 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 158189008936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158189008937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158189008938 hypothetical protein; Provisional; Region: PRK08262 158189008939 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 158189008940 metal binding site [ion binding]; metal-binding site 158189008941 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 158189008942 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 158189008943 putative dimer interface [polypeptide binding]; other site 158189008944 ornithine carbamoyltransferase; Validated; Region: PRK02102 158189008945 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 158189008946 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 158189008947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 158189008948 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 158189008949 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 158189008950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189008951 ABC-ATPase subunit interface; other site 158189008952 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 158189008953 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 158189008954 Walker A/P-loop; other site 158189008955 ATP binding site [chemical binding]; other site 158189008956 Q-loop/lid; other site 158189008957 ABC transporter signature motif; other site 158189008958 Walker B; other site 158189008959 D-loop; other site 158189008960 H-loop/switch region; other site 158189008961 NIL domain; Region: NIL; pfam09383 158189008962 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 158189008963 MFS/sugar transport protein; Region: MFS_2; pfam13347 158189008964 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 158189008965 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158189008966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158189008967 putative substrate translocation pore; other site 158189008968 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 158189008969 intersubunit interface [polypeptide binding]; other site 158189008970 active site 158189008971 catalytic residue [active] 158189008972 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 158189008973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 158189008974 active site 158189008975 motif I; other site 158189008976 motif II; other site 158189008977 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 158189008978 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 158189008979 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 158189008980 Zn binding site [ion binding]; other site 158189008981 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 158189008982 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 158189008983 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 158189008984 active site 158189008985 dimer interface [polypeptide binding]; other site 158189008986 motif 1; other site 158189008987 motif 2; other site 158189008988 motif 3; other site 158189008989 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 158189008990 anticodon binding site; other site 158189008991 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 158189008992 GAF domain; Region: GAF_2; pfam13185 158189008993 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 158189008994 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158189008995 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158189008996 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 158189008997 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 158189008998 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158189008999 4Fe-4S binding domain; Region: Fer4; pfam00037 158189009000 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158189009001 Putative Fe-S cluster; Region: FeS; cl17515 158189009002 PAS domain; Region: PAS_8; pfam13188 158189009003 PAS domain; Region: PAS_9; pfam13426 158189009004 putative active site [active] 158189009005 heme pocket [chemical binding]; other site 158189009006 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 158189009007 dimer interface [polypeptide binding]; other site 158189009008 [2Fe-2S] cluster binding site [ion binding]; other site 158189009009 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 158189009010 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 158189009011 CoA binding domain; Region: CoA_binding; pfam02629 158189009012 LytB protein; Region: LYTB; cl00507 158189009013 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 158189009014 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 158189009015 Protein export membrane protein; Region: SecD_SecF; pfam02355 158189009016 protein-export membrane protein SecD; Region: secD; TIGR01129 158189009017 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 158189009018 Preprotein translocase subunit; Region: YajC; pfam02699 158189009019 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 158189009020 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 158189009021 ring oligomerisation interface [polypeptide binding]; other site 158189009022 ATP/Mg binding site [chemical binding]; other site 158189009023 stacking interactions; other site 158189009024 hinge regions; other site 158189009025 Integral membrane protein DUF92; Region: DUF92; pfam01940 158189009026 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 158189009027 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 158189009028 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 158189009029 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 158189009030 Phosphatidylinositol N-acetylglucosaminyltransferase; Region: GPI2; pfam06432 158189009031 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 158189009032 Arginine repressor [Transcription]; Region: ArgR; COG1438 158189009033 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 158189009034 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 158189009035 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 158189009036 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 158189009037 active site 158189009038 dimer interface [polypeptide binding]; other site 158189009039 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 158189009040 dimer interface [polypeptide binding]; other site 158189009041 active site 158189009042 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158189009043 MarR family; Region: MarR_2; pfam12802 158189009044 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158189009045 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158189009046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189009047 Walker A/P-loop; other site 158189009048 ATP binding site [chemical binding]; other site 158189009049 Q-loop/lid; other site 158189009050 ABC transporter signature motif; other site 158189009051 Walker B; other site 158189009052 D-loop; other site 158189009053 H-loop/switch region; other site 158189009054 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158189009055 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158189009056 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 158189009057 Walker A/P-loop; other site 158189009058 ATP binding site [chemical binding]; other site 158189009059 Q-loop/lid; other site 158189009060 ABC transporter signature motif; other site 158189009061 Walker B; other site 158189009062 D-loop; other site 158189009063 H-loop/switch region; other site 158189009064 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 158189009065 EamA-like transporter family; Region: EamA; pfam00892 158189009066 EamA-like transporter family; Region: EamA; pfam00892 158189009067 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 158189009068 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 158189009069 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 158189009070 6-phosphofructokinase; Region: PLN02884 158189009071 active site 158189009072 ADP/pyrophosphate binding site [chemical binding]; other site 158189009073 dimerization interface [polypeptide binding]; other site 158189009074 allosteric effector site; other site 158189009075 fructose-1,6-bisphosphate binding site; other site 158189009076 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 158189009077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 158189009078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158189009079 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 158189009080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158189009081 homodimer interface [polypeptide binding]; other site 158189009082 catalytic residue [active] 158189009083 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 158189009084 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 158189009085 nucleotide binding pocket [chemical binding]; other site 158189009086 K-X-D-G motif; other site 158189009087 catalytic site [active] 158189009088 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 158189009089 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 158189009090 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 158189009091 Dimer interface [polypeptide binding]; other site 158189009092 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158189009093 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 158189009094 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 158189009095 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 158189009096 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 158189009097 active site 158189009098 PHP Thumb interface [polypeptide binding]; other site 158189009099 metal binding site [ion binding]; metal-binding site 158189009100 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 158189009101 generic binding surface I; other site 158189009102 generic binding surface II; other site 158189009103 YGGT family; Region: YGGT; pfam02325 158189009104 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 158189009105 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 158189009106 ssDNA binding site; other site 158189009107 generic binding surface II; other site 158189009108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158189009109 ATP binding site [chemical binding]; other site 158189009110 putative Mg++ binding site [ion binding]; other site 158189009111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158189009112 nucleotide binding region [chemical binding]; other site 158189009113 ATP-binding site [chemical binding]; other site 158189009114 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 158189009115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189009116 S-adenosylmethionine binding site [chemical binding]; other site 158189009117 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 158189009118 active site 158189009119 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 158189009120 active site 2 [active] 158189009121 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 158189009122 lipoprotein signal peptidase; Provisional; Region: PRK14787 158189009123 Uncharacterized conserved protein [Function unknown]; Region: COG0327 158189009124 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 158189009125 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 158189009126 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 158189009127 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 158189009128 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158189009129 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 158189009130 Predicted methyltransferases [General function prediction only]; Region: COG0313 158189009131 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 158189009132 putative SAM binding site [chemical binding]; other site 158189009133 putative homodimer interface [polypeptide binding]; other site 158189009134 phage shock protein A; Region: phageshock_pspA; TIGR02977 158189009135 phage shock protein C; Region: phageshock_pspC; TIGR02978 158189009136 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 158189009137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189009138 Walker A motif; other site 158189009139 ATP binding site [chemical binding]; other site 158189009140 Walker B motif; other site 158189009141 arginine finger; other site 158189009142 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 158189009143 phage shock protein A; Region: phageshock_pspA; TIGR02977 158189009144 PspC domain; Region: PspC; cl00864 158189009145 phage shock protein C; Region: phageshock_pspC; TIGR02978 158189009146 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 158189009147 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 158189009148 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 158189009149 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 158189009150 adaptive-response sensory kinase; Validated; Region: PRK09303 158189009151 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 158189009152 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158189009153 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158189009154 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 158189009155 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158189009156 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158189009157 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 158189009158 IMP binding site; other site 158189009159 dimer interface [polypeptide binding]; other site 158189009160 interdomain contacts; other site 158189009161 partial ornithine binding site; other site 158189009162 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 158189009163 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 158189009164 dimer interface [polypeptide binding]; other site 158189009165 anticodon binding site; other site 158189009166 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 158189009167 homodimer interface [polypeptide binding]; other site 158189009168 motif 1; other site 158189009169 active site 158189009170 motif 2; other site 158189009171 GAD domain; Region: GAD; pfam02938 158189009172 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 158189009173 motif 3; other site 158189009174 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 158189009175 Cation efflux family; Region: Cation_efflux; cl00316 158189009176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189009177 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189009178 metal binding site [ion binding]; metal-binding site 158189009179 active site 158189009180 I-site; other site 158189009181 OsmC-like protein; Region: OsmC; pfam02566 158189009182 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 158189009183 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 158189009184 intersubunit interface [polypeptide binding]; other site 158189009185 active site 158189009186 Zn2+ binding site [ion binding]; other site 158189009187 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158189009188 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158189009189 DNA binding site [nucleotide binding] 158189009190 domain linker motif; other site 158189009191 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189009192 dimerization interface [polypeptide binding]; other site 158189009193 ligand binding site [chemical binding]; other site 158189009194 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 158189009195 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 158189009196 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189009197 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189009198 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189009199 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189009200 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158189009201 prolyl-tRNA synthetase; Provisional; Region: PRK09194 158189009202 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 158189009203 dimer interface [polypeptide binding]; other site 158189009204 motif 1; other site 158189009205 active site 158189009206 motif 2; other site 158189009207 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 158189009208 putative deacylase active site [active] 158189009209 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 158189009210 active site 158189009211 motif 3; other site 158189009212 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 158189009213 anticodon binding site; other site 158189009214 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 158189009215 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158189009216 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158189009217 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 158189009218 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 158189009219 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158189009220 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 158189009221 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 158189009222 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 158189009223 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 158189009224 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158189009225 adenosine deaminase; Provisional; Region: PRK09358 158189009226 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 158189009227 active site 158189009228 Rhomboid family; Region: Rhomboid; pfam01694 158189009229 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 158189009230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158189009231 S-adenosylmethionine binding site [chemical binding]; other site 158189009232 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 158189009233 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 158189009234 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 158189009235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189009236 Walker A/P-loop; other site 158189009237 ATP binding site [chemical binding]; other site 158189009238 Q-loop/lid; other site 158189009239 ABC transporter signature motif; other site 158189009240 Walker B; other site 158189009241 D-loop; other site 158189009242 H-loop/switch region; other site 158189009243 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 158189009244 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 158189009245 ABC-ATPase subunit interface; other site 158189009246 putative PBP binding regions; other site 158189009247 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 158189009248 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158189009249 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 158189009250 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 158189009251 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 158189009252 active site 158189009253 NAD binding site [chemical binding]; other site 158189009254 metal binding site [ion binding]; metal-binding site 158189009255 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 158189009256 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158189009257 PYR/PP interface [polypeptide binding]; other site 158189009258 dimer interface [polypeptide binding]; other site 158189009259 TPP binding site [chemical binding]; other site 158189009260 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158189009261 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158189009262 TPP-binding site [chemical binding]; other site 158189009263 dimer interface [polypeptide binding]; other site 158189009264 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 158189009265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189009266 DNA-binding site [nucleotide binding]; DNA binding site 158189009267 FCD domain; Region: FCD; pfam07729 158189009268 Domain of unknown function (DUF362); Region: DUF362; pfam04015 158189009269 Uncharacterized conserved protein [Function unknown]; Region: COG2006 158189009270 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189009271 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189009272 active site 158189009273 catalytic tetrad [active] 158189009274 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158189009275 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 158189009276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158189009277 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 158189009278 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158189009279 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 158189009280 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 158189009281 Propionate catabolism activator; Region: PrpR_N; pfam06506 158189009282 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 158189009283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189009284 Walker B motif; other site 158189009285 arginine finger; other site 158189009286 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 158189009287 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 158189009288 Mechanosensitive ion channel; Region: MS_channel; pfam00924 158189009289 heat shock protein 90; Provisional; Region: PRK05218 158189009290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189009291 ATP binding site [chemical binding]; other site 158189009292 Mg2+ binding site [ion binding]; other site 158189009293 G-X-G motif; other site 158189009294 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158189009295 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158189009296 nucleotide binding site [chemical binding]; other site 158189009297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189009298 DNA-binding site [nucleotide binding]; DNA binding site 158189009299 transcriptional regulator NanR; Provisional; Region: PRK03837 158189009300 FCD domain; Region: FCD; pfam07729 158189009301 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158189009302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158189009303 DNA-binding site [nucleotide binding]; DNA binding site 158189009304 FCD domain; Region: FCD; pfam07729 158189009305 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158189009306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189009307 Walker A/P-loop; other site 158189009308 ATP binding site [chemical binding]; other site 158189009309 Q-loop/lid; other site 158189009310 ABC transporter signature motif; other site 158189009311 Walker B; other site 158189009312 D-loop; other site 158189009313 H-loop/switch region; other site 158189009314 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 158189009315 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158189009316 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158189009317 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 158189009318 putative active site [active] 158189009319 putative metal binding site [ion binding]; other site 158189009320 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 158189009321 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 158189009322 classical (c) SDRs; Region: SDR_c; cd05233 158189009323 NAD(P) binding site [chemical binding]; other site 158189009324 active site 158189009325 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 158189009326 purine nucleoside phosphorylase; Provisional; Region: PRK08202 158189009327 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189009328 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189009329 TM-ABC transporter signature motif; other site 158189009330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158189009331 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158189009332 TM-ABC transporter signature motif; other site 158189009333 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158189009334 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158189009335 Walker A/P-loop; other site 158189009336 ATP binding site [chemical binding]; other site 158189009337 Q-loop/lid; other site 158189009338 ABC transporter signature motif; other site 158189009339 Walker B; other site 158189009340 D-loop; other site 158189009341 H-loop/switch region; other site 158189009342 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158189009343 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158189009344 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 158189009345 ligand binding site [chemical binding]; other site 158189009346 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 158189009347 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189009348 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158189009349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189009350 dimer interface [polypeptide binding]; other site 158189009351 conserved gate region; other site 158189009352 putative PBP binding loops; other site 158189009353 ABC-ATPase subunit interface; other site 158189009354 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158189009355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189009356 dimer interface [polypeptide binding]; other site 158189009357 conserved gate region; other site 158189009358 ABC-ATPase subunit interface; other site 158189009359 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 158189009360 Predicted transcriptional regulators [Transcription]; Region: COG1695 158189009361 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 158189009362 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 158189009363 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158189009364 ligand binding site [chemical binding]; other site 158189009365 dimerization interface [polypeptide binding]; other site 158189009366 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 158189009367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158189009368 bile acid transporter; Region: bass; TIGR00841 158189009369 Sodium Bile acid symporter family; Region: SBF; cl17470 158189009370 altronate oxidoreductase; Provisional; Region: PRK03643 158189009371 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 158189009372 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 158189009373 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 158189009374 galactarate dehydratase; Region: galactar-dH20; TIGR03248 158189009375 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 158189009376 Glucuronate isomerase; Region: UxaC; pfam02614 158189009377 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 158189009378 Transcriptional regulator [Transcription]; Region: IclR; COG1414 158189009379 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 158189009380 Bacterial transcriptional regulator; Region: IclR; pfam01614 158189009381 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158189009382 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158189009383 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158189009384 Cupin domain; Region: Cupin_2; pfam07883 158189009385 Predicted permeases [General function prediction only]; Region: COG0679 158189009386 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158189009387 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158189009388 putative acyl-acceptor binding pocket; other site 158189009389 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 158189009390 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 158189009391 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 158189009392 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 158189009393 diiron binding motif [ion binding]; other site 158189009394 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158189009395 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 158189009396 substrate binding site [chemical binding]; other site 158189009397 ATP binding site [chemical binding]; other site 158189009398 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 158189009399 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 158189009400 active site 158189009401 intersubunit interface [polypeptide binding]; other site 158189009402 catalytic residue [active] 158189009403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158189009404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158189009405 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158189009406 Coenzyme A binding pocket [chemical binding]; other site 158189009407 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158189009408 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158189009409 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158189009410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189009411 dimer interface [polypeptide binding]; other site 158189009412 conserved gate region; other site 158189009413 putative PBP binding loops; other site 158189009414 ABC-ATPase subunit interface; other site 158189009415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158189009416 dimer interface [polypeptide binding]; other site 158189009417 conserved gate region; other site 158189009418 putative PBP binding loops; other site 158189009419 ABC-ATPase subunit interface; other site 158189009420 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158189009421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158189009422 Walker A/P-loop; other site 158189009423 ATP binding site [chemical binding]; other site 158189009424 Q-loop/lid; other site 158189009425 ABC transporter signature motif; other site 158189009426 Walker B; other site 158189009427 D-loop; other site 158189009428 H-loop/switch region; other site 158189009429 TOBE domain; Region: TOBE_2; pfam08402 158189009430 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 158189009431 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 158189009432 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158189009433 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158189009434 Metal-binding active site; metal-binding site 158189009435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 158189009436 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 158189009437 ATP binding site [chemical binding]; other site 158189009438 putative Mg++ binding site [ion binding]; other site 158189009439 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 158189009440 intersubunit interface [polypeptide binding]; other site 158189009441 active site 158189009442 catalytic residue [active] 158189009443 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 158189009444 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 158189009445 Zn binding site [ion binding]; other site 158189009446 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 158189009447 putative active site [active] 158189009448 nucleotide binding site [chemical binding]; other site 158189009449 nudix motif; other site 158189009450 putative metal binding site [ion binding]; other site 158189009451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158189009452 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158189009453 active site 158189009454 catalytic tetrad [active] 158189009455 Uncharacterized conserved protein [Function unknown]; Region: COG1739 158189009456 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 158189009457 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 158189009458 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 158189009459 metal binding site [ion binding]; metal-binding site 158189009460 PAS domain S-box; Region: sensory_box; TIGR00229 158189009461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158189009462 putative active site [active] 158189009463 heme pocket [chemical binding]; other site 158189009464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158189009465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158189009466 metal binding site [ion binding]; metal-binding site 158189009467 active site 158189009468 I-site; other site 158189009469 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 158189009470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158189009471 Walker A motif; other site 158189009472 ATP binding site [chemical binding]; other site 158189009473 Walker B motif; other site 158189009474 arginine finger; other site 158189009475 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 158189009476 hypothetical protein; Validated; Region: PRK00153 158189009477 recombination protein RecR; Reviewed; Region: recR; PRK00076 158189009478 RecR protein; Region: RecR; pfam02132 158189009479 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 158189009480 putative active site [active] 158189009481 putative metal-binding site [ion binding]; other site 158189009482 tetramer interface [polypeptide binding]; other site 158189009483 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 158189009484 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 158189009485 putative metal binding site [ion binding]; other site 158189009486 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 158189009487 HSP70 interaction site [polypeptide binding]; other site 158189009488 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 158189009489 Trehalase; Region: Trehalase; cl17346 158189009490 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 158189009491 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 158189009492 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 158189009493 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 158189009494 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 158189009495 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 158189009496 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 158189009497 active site 158189009498 dimer interface [polypeptide binding]; other site 158189009499 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 158189009500 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 158189009501 metal binding site [ion binding]; metal-binding site 158189009502 dimer interface [polypeptide binding]; other site 158189009503 Peptidase C26; Region: Peptidase_C26; pfam07722 158189009504 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 158189009505 catalytic triad [active] 158189009506 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 158189009507 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158189009508 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158189009509 Protein of unknown function DUF45; Region: DUF45; pfam01863 158189009510 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 158189009511 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 158189009512 DNA repair protein RadA; Provisional; Region: PRK11823 158189009513 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 158189009514 Walker A motif; other site 158189009515 ATP binding site [chemical binding]; other site 158189009516 Walker B motif; other site 158189009517 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 158189009518 active site 158189009519 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 158189009520 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 158189009521 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 158189009522 ParB-like nuclease domain; Region: ParBc; pfam02195 158189009523 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 158189009524 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 158189009525 P-loop; other site 158189009526 Magnesium ion binding site [ion binding]; other site 158189009527 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 158189009528 Magnesium ion binding site [ion binding]; other site 158189009529 NifU-like domain; Region: NifU; pfam01106 158189009530 DNA gyrase subunit A; Validated; Region: PRK05560 158189009531 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 158189009532 CAP-like domain; other site 158189009533 active site 158189009534 primary dimer interface [polypeptide binding]; other site 158189009535 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158189009536 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158189009537 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158189009538 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158189009539 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158189009540 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 158189009541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158189009542 ATP binding site [chemical binding]; other site 158189009543 Mg2+ binding site [ion binding]; other site 158189009544 G-X-G motif; other site 158189009545 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 158189009546 anchoring element; other site 158189009547 dimer interface [polypeptide binding]; other site 158189009548 ATP binding site [chemical binding]; other site 158189009549 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 158189009550 active site 158189009551 putative metal-binding site [ion binding]; other site 158189009552 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986