-- dump date 20140620_071536 -- class Genbank::misc_feature -- table misc_feature_note -- id note 158190000001 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 158190000002 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190000003 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190000004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000005 dimer interface [polypeptide binding]; other site 158190000006 conserved gate region; other site 158190000007 putative PBP binding loops; other site 158190000008 ABC-ATPase subunit interface; other site 158190000009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000010 dimer interface [polypeptide binding]; other site 158190000011 conserved gate region; other site 158190000012 putative PBP binding loops; other site 158190000013 ABC-ATPase subunit interface; other site 158190000014 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190000015 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 158190000016 Walker A/P-loop; other site 158190000017 ATP binding site [chemical binding]; other site 158190000018 Q-loop/lid; other site 158190000019 ABC transporter signature motif; other site 158190000020 Walker B; other site 158190000021 D-loop; other site 158190000022 H-loop/switch region; other site 158190000023 TOBE domain; Region: TOBE_2; pfam08402 158190000024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 158190000025 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 158190000026 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 158190000027 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 158190000028 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 158190000029 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 158190000030 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 158190000031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190000032 putative substrate translocation pore; other site 158190000033 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190000034 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 158190000035 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 158190000036 active site 158190000037 putative substrate binding pocket [chemical binding]; other site 158190000038 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190000039 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 158190000040 ligand binding site [chemical binding]; other site 158190000041 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190000042 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190000043 Walker A/P-loop; other site 158190000044 ATP binding site [chemical binding]; other site 158190000045 Q-loop/lid; other site 158190000046 ABC transporter signature motif; other site 158190000047 Walker B; other site 158190000048 D-loop; other site 158190000049 H-loop/switch region; other site 158190000050 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190000051 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190000052 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190000053 TM-ABC transporter signature motif; other site 158190000054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190000055 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190000056 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190000057 TM-ABC transporter signature motif; other site 158190000058 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 158190000059 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 158190000060 DNA binding residues [nucleotide binding] 158190000061 drug binding residues [chemical binding]; other site 158190000062 dimer interface [polypeptide binding]; other site 158190000063 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 158190000064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 158190000065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190000066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158190000067 Coenzyme A binding pocket [chemical binding]; other site 158190000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 158190000069 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158190000070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158190000071 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 158190000072 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 158190000073 active site 158190000074 intersubunit interface [polypeptide binding]; other site 158190000075 catalytic residue [active] 158190000076 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 158190000077 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158190000078 substrate binding site [chemical binding]; other site 158190000079 ATP binding site [chemical binding]; other site 158190000080 Transcriptional regulator [Transcription]; Region: IclR; COG1414 158190000081 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 158190000082 Bacterial transcriptional regulator; Region: IclR; pfam01614 158190000083 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 158190000084 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158190000085 minor groove reading motif; other site 158190000086 helix-hairpin-helix signature motif; other site 158190000087 substrate binding pocket [chemical binding]; other site 158190000088 active site 158190000089 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 158190000090 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 158190000091 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 158190000092 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 158190000093 nucleotide binding site [chemical binding]; other site 158190000094 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 158190000095 dimer interface [polypeptide binding]; other site 158190000096 putative threonine allosteric regulatory site; other site 158190000097 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 158190000098 putative threonine allosteric regulatory site; other site 158190000099 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 158190000100 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 158190000101 threonine synthase; Validated; Region: PRK09225 158190000102 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 158190000103 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190000104 catalytic residue [active] 158190000105 Uncharacterized conserved protein [Function unknown]; Region: COG2014 158190000106 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 158190000107 Domain of unknown function (DUF364); Region: DUF364; pfam04016 158190000108 galactokinase; Provisional; Region: PRK05322 158190000109 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 158190000110 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 158190000111 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 158190000112 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 158190000113 dimer interface [polypeptide binding]; other site 158190000114 active site 158190000115 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190000116 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190000117 DNA binding site [nucleotide binding] 158190000118 domain linker motif; other site 158190000119 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190000120 ligand binding site [chemical binding]; other site 158190000121 dimerization interface [polypeptide binding]; other site 158190000122 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 158190000123 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158190000124 active site 158190000125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190000126 non-specific DNA binding site [nucleotide binding]; other site 158190000127 salt bridge; other site 158190000128 sequence-specific DNA binding site [nucleotide binding]; other site 158190000129 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 158190000130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190000131 ATP binding site [chemical binding]; other site 158190000132 putative Mg++ binding site [ion binding]; other site 158190000133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190000134 nucleotide binding region [chemical binding]; other site 158190000135 ATP-binding site [chemical binding]; other site 158190000136 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 158190000137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190000138 active site 158190000139 phosphorylation site [posttranslational modification] 158190000140 intermolecular recognition site; other site 158190000141 dimerization interface [polypeptide binding]; other site 158190000142 LytTr DNA-binding domain; Region: LytTR; smart00850 158190000143 flagellin; Validated; Region: PRK08026 158190000144 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 158190000145 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 158190000146 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158190000147 active site 158190000148 catalytic tetrad [active] 158190000149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190000150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190000151 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158190000152 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158190000153 putative acyl-acceptor binding pocket; other site 158190000154 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 158190000155 reactive center loop; other site 158190000156 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190000157 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190000158 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190000159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000160 dimer interface [polypeptide binding]; other site 158190000161 conserved gate region; other site 158190000162 putative PBP binding loops; other site 158190000163 ABC-ATPase subunit interface; other site 158190000164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000165 dimer interface [polypeptide binding]; other site 158190000166 conserved gate region; other site 158190000167 putative PBP binding loops; other site 158190000168 ABC-ATPase subunit interface; other site 158190000169 4Fe-4S binding domain; Region: Fer4_5; pfam12801 158190000170 4Fe-4S binding domain; Region: Fer4_5; pfam12801 158190000171 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 158190000172 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190000173 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 158190000174 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190000175 active site 158190000176 metal binding site [ion binding]; metal-binding site 158190000177 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 158190000178 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 158190000179 DOMON-like domain of copper-dependent monooxygenases and related proteins; Region: DOMON_DOH; cd09631 158190000180 DOMON domain; Region: DOMON; pfam03351 158190000181 putative ligand binding site [chemical binding]; other site 158190000182 LCCL domain; Region: LCCL; pfam03815 158190000183 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 158190000184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190000185 active site 158190000186 phosphorylation site [posttranslational modification] 158190000187 intermolecular recognition site; other site 158190000188 dimerization interface [polypeptide binding]; other site 158190000189 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190000190 Zn2+ binding site [ion binding]; other site 158190000191 Mg2+ binding site [ion binding]; other site 158190000192 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158190000193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190000194 substrate binding pocket [chemical binding]; other site 158190000195 membrane-bound complex binding site; other site 158190000196 hinge residues; other site 158190000197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190000198 dimer interface [polypeptide binding]; other site 158190000199 phosphorylation site [posttranslational modification] 158190000200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190000201 ATP binding site [chemical binding]; other site 158190000202 Mg2+ binding site [ion binding]; other site 158190000203 G-X-G motif; other site 158190000204 Response regulator receiver domain; Region: Response_reg; pfam00072 158190000205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190000206 active site 158190000207 phosphorylation site [posttranslational modification] 158190000208 intermolecular recognition site; other site 158190000209 dimerization interface [polypeptide binding]; other site 158190000210 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 158190000211 Uncharacterized conserved protein [Function unknown]; Region: COG2461 158190000212 Nucleoside diphosphate kinase; Region: NDK; pfam00334 158190000213 active site 158190000214 multimer interface [polypeptide binding]; other site 158190000215 Isochorismatase family; Region: Isochorismatase; pfam00857 158190000216 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 158190000217 catalytic triad [active] 158190000218 conserved cis-peptide bond; other site 158190000219 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 158190000220 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 158190000221 non-heme iron binding site [ion binding]; other site 158190000222 PBP superfamily domain; Region: PBP_like_2; cl17296 158190000223 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 158190000224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000225 dimer interface [polypeptide binding]; other site 158190000226 conserved gate region; other site 158190000227 putative PBP binding loops; other site 158190000228 ABC-ATPase subunit interface; other site 158190000229 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 158190000230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000231 dimer interface [polypeptide binding]; other site 158190000232 conserved gate region; other site 158190000233 ABC-ATPase subunit interface; other site 158190000234 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 158190000235 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 158190000236 Walker A/P-loop; other site 158190000237 ATP binding site [chemical binding]; other site 158190000238 Q-loop/lid; other site 158190000239 ABC transporter signature motif; other site 158190000240 Walker B; other site 158190000241 D-loop; other site 158190000242 H-loop/switch region; other site 158190000243 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 158190000244 PhoU domain; Region: PhoU; pfam01895 158190000245 PhoU domain; Region: PhoU; pfam01895 158190000246 FemAB family; Region: FemAB; pfam02388 158190000247 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 158190000248 XdhC Rossmann domain; Region: XdhC_C; pfam13478 158190000249 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 158190000250 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158190000251 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 158190000252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190000253 catalytic residue [active] 158190000254 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 158190000255 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 158190000256 CPxP motif; other site 158190000257 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 158190000258 selenophosphate synthetase; Provisional; Region: PRK00943 158190000259 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 158190000260 dimerization interface [polypeptide binding]; other site 158190000261 putative ATP binding site [chemical binding]; other site 158190000262 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 158190000263 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 158190000264 putative active site [active] 158190000265 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190000266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000267 dimer interface [polypeptide binding]; other site 158190000268 conserved gate region; other site 158190000269 putative PBP binding loops; other site 158190000270 ABC-ATPase subunit interface; other site 158190000271 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 158190000272 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190000273 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190000274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190000275 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 158190000276 Ligand binding site [chemical binding]; other site 158190000277 Electron transfer flavoprotein domain; Region: ETF; pfam01012 158190000278 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 158190000279 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 158190000280 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 158190000281 FAD binding domain; Region: FAD_binding_4; pfam01565 158190000282 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 158190000283 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 158190000284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190000285 Coenzyme A binding pocket [chemical binding]; other site 158190000286 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 158190000287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190000288 FeS/SAM binding site; other site 158190000289 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 158190000290 Membrane transport protein; Region: Mem_trans; cl09117 158190000291 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 158190000292 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 158190000293 XdhC Rossmann domain; Region: XdhC_C; pfam13478 158190000294 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 158190000295 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 158190000296 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 158190000297 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 158190000298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190000299 dimer interface [polypeptide binding]; other site 158190000300 phosphorylation site [posttranslational modification] 158190000301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190000302 ATP binding site [chemical binding]; other site 158190000303 Mg2+ binding site [ion binding]; other site 158190000304 G-X-G motif; other site 158190000305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190000306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190000307 active site 158190000308 phosphorylation site [posttranslational modification] 158190000309 intermolecular recognition site; other site 158190000310 dimerization interface [polypeptide binding]; other site 158190000311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190000312 DNA binding site [nucleotide binding] 158190000313 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 158190000314 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 158190000315 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 158190000316 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 158190000317 propionate/acetate kinase; Provisional; Region: PRK12379 158190000318 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 158190000319 FAD binding domain; Region: FAD_binding_4; pfam01565 158190000320 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 158190000321 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 158190000322 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 158190000323 active site 158190000324 HIGH motif; other site 158190000325 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 158190000326 KMSKS motif; other site 158190000327 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 158190000328 tRNA binding surface [nucleotide binding]; other site 158190000329 anticodon binding site; other site 158190000330 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 158190000331 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 158190000332 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158190000333 DNA binding residues [nucleotide binding] 158190000334 Putative zinc-finger; Region: zf-HC2; pfam13490 158190000335 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 158190000336 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158190000337 active site 158190000338 HIGH motif; other site 158190000339 nucleotide binding site [chemical binding]; other site 158190000340 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 158190000341 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 158190000342 active site 158190000343 KMSKS motif; other site 158190000344 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 158190000345 tRNA binding surface [nucleotide binding]; other site 158190000346 anticodon binding site; other site 158190000347 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 158190000348 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158190000349 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 158190000350 active site 158190000351 metal binding site [ion binding]; metal-binding site 158190000352 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 158190000353 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 158190000354 DXD motif; other site 158190000355 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 158190000356 Peptidase family U32; Region: Peptidase_U32; pfam01136 158190000357 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 158190000358 Found in ATP-dependent protease La (LON); Region: LON; smart00464 158190000359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190000360 Walker A motif; other site 158190000361 ATP binding site [chemical binding]; other site 158190000362 Walker B motif; other site 158190000363 arginine finger; other site 158190000364 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 158190000365 carbamate kinase; Reviewed; Region: PRK12686 158190000366 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 158190000367 putative substrate binding site [chemical binding]; other site 158190000368 nucleotide binding site [chemical binding]; other site 158190000369 nucleotide binding site [chemical binding]; other site 158190000370 homodimer interface [polypeptide binding]; other site 158190000371 LemA family; Region: LemA; cl00742 158190000372 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 158190000373 Recombination protein O N terminal; Region: RecO_N; pfam11967 158190000374 Recombination protein O C terminal; Region: RecO_C; pfam02565 158190000375 DHH family; Region: DHH; pfam01368 158190000376 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 158190000377 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 158190000378 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 158190000379 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 158190000380 ligand binding site [chemical binding]; other site 158190000381 NAD binding site [chemical binding]; other site 158190000382 dimerization interface [polypeptide binding]; other site 158190000383 catalytic site [active] 158190000384 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 158190000385 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190000386 catalytic residue [active] 158190000387 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 158190000388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190000389 putative DNA binding site [nucleotide binding]; other site 158190000390 putative Zn2+ binding site [ion binding]; other site 158190000391 AsnC family; Region: AsnC_trans_reg; pfam01037 158190000392 flavodoxin; Provisional; Region: PRK06242 158190000393 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 158190000394 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158190000395 phosphate binding site [ion binding]; other site 158190000396 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 158190000397 putative acyl-acceptor binding pocket; other site 158190000398 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 158190000399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190000400 ATP binding site [chemical binding]; other site 158190000401 Mg2+ binding site [ion binding]; other site 158190000402 G-X-G motif; other site 158190000403 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 158190000404 ATP binding site [chemical binding]; other site 158190000405 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 158190000406 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 158190000407 Ligand Binding Site [chemical binding]; other site 158190000408 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 158190000409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190000410 Zn2+ binding site [ion binding]; other site 158190000411 Mg2+ binding site [ion binding]; other site 158190000412 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 158190000413 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158190000414 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158190000415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000416 dimer interface [polypeptide binding]; other site 158190000417 conserved gate region; other site 158190000418 putative PBP binding loops; other site 158190000419 ABC-ATPase subunit interface; other site 158190000420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000421 dimer interface [polypeptide binding]; other site 158190000422 conserved gate region; other site 158190000423 putative PBP binding loops; other site 158190000424 ABC-ATPase subunit interface; other site 158190000425 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190000426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190000427 Walker A/P-loop; other site 158190000428 ATP binding site [chemical binding]; other site 158190000429 Q-loop/lid; other site 158190000430 ABC transporter signature motif; other site 158190000431 Walker B; other site 158190000432 D-loop; other site 158190000433 H-loop/switch region; other site 158190000434 TOBE domain; Region: TOBE_2; pfam08402 158190000435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190000436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190000437 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 158190000438 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 158190000439 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 158190000440 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 158190000441 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 158190000442 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158190000443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190000444 DNA-binding site [nucleotide binding]; DNA binding site 158190000445 FCD domain; Region: FCD; pfam07729 158190000446 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190000447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000448 dimer interface [polypeptide binding]; other site 158190000449 conserved gate region; other site 158190000450 putative PBP binding loops; other site 158190000451 ABC-ATPase subunit interface; other site 158190000452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158190000453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000454 dimer interface [polypeptide binding]; other site 158190000455 putative PBP binding loops; other site 158190000456 ABC-ATPase subunit interface; other site 158190000457 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190000458 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 158190000459 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158190000460 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190000461 substrate binding pocket [chemical binding]; other site 158190000462 membrane-bound complex binding site; other site 158190000463 hinge residues; other site 158190000464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000465 dimer interface [polypeptide binding]; other site 158190000466 conserved gate region; other site 158190000467 putative PBP binding loops; other site 158190000468 ABC-ATPase subunit interface; other site 158190000469 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158190000470 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158190000471 Walker A/P-loop; other site 158190000472 ATP binding site [chemical binding]; other site 158190000473 Q-loop/lid; other site 158190000474 ABC transporter signature motif; other site 158190000475 Walker B; other site 158190000476 D-loop; other site 158190000477 H-loop/switch region; other site 158190000478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190000479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190000480 metal binding site [ion binding]; metal-binding site 158190000481 active site 158190000482 I-site; other site 158190000483 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190000484 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158190000485 substrate binding pocket [chemical binding]; other site 158190000486 membrane-bound complex binding site; other site 158190000487 hinge residues; other site 158190000488 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 158190000489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000490 dimer interface [polypeptide binding]; other site 158190000491 conserved gate region; other site 158190000492 putative PBP binding loops; other site 158190000493 ABC-ATPase subunit interface; other site 158190000494 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158190000495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190000496 Walker A/P-loop; other site 158190000497 ATP binding site [chemical binding]; other site 158190000498 Q-loop/lid; other site 158190000499 ABC transporter signature motif; other site 158190000500 Walker B; other site 158190000501 D-loop; other site 158190000502 H-loop/switch region; other site 158190000503 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 158190000504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190000505 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 158190000506 putative ADP-binding pocket [chemical binding]; other site 158190000507 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 158190000508 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158190000509 NAD(P) binding site [chemical binding]; other site 158190000510 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158190000511 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 158190000512 nucleotide binding site [chemical binding]; other site 158190000513 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 158190000514 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 158190000515 putative active site; other site 158190000516 catalytic residue [active] 158190000517 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190000518 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190000519 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190000520 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190000521 Walker A/P-loop; other site 158190000522 ATP binding site [chemical binding]; other site 158190000523 Q-loop/lid; other site 158190000524 ABC transporter signature motif; other site 158190000525 Walker B; other site 158190000526 D-loop; other site 158190000527 H-loop/switch region; other site 158190000528 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190000529 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190000530 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190000531 TM-ABC transporter signature motif; other site 158190000532 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190000533 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190000534 TM-ABC transporter signature motif; other site 158190000535 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158190000536 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 158190000537 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 158190000538 DctM-like transporters; Region: DctM; pfam06808 158190000539 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 158190000540 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 158190000541 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190000542 membrane-bound complex binding site; other site 158190000543 hinge residues; other site 158190000544 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 158190000545 UbiA prenyltransferase family; Region: UbiA; pfam01040 158190000546 PAS domain; Region: PAS_9; pfam13426 158190000547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158190000548 putative active site [active] 158190000549 heme pocket [chemical binding]; other site 158190000550 GAF domain; Region: GAF_2; pfam13185 158190000551 GAF domain; Region: GAF_3; pfam13492 158190000552 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 158190000553 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190000554 Zn2+ binding site [ion binding]; other site 158190000555 Mg2+ binding site [ion binding]; other site 158190000556 Borrelia membrane protein P13; Region: Borrelia_P13; pfam05628 158190000557 DAK2 domain; Region: Dak2; pfam02734 158190000558 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 158190000559 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 158190000560 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 158190000561 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190000562 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190000563 TM-ABC transporter signature motif; other site 158190000564 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190000565 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190000566 TM-ABC transporter signature motif; other site 158190000567 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190000568 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190000569 Walker A/P-loop; other site 158190000570 ATP binding site [chemical binding]; other site 158190000571 Q-loop/lid; other site 158190000572 ABC transporter signature motif; other site 158190000573 Walker B; other site 158190000574 D-loop; other site 158190000575 H-loop/switch region; other site 158190000576 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190000577 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 158190000578 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190000579 ligand binding site [chemical binding]; other site 158190000580 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190000581 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190000582 DNA binding site [nucleotide binding] 158190000583 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190000584 ligand binding site [chemical binding]; other site 158190000585 dimerization interface [polypeptide binding]; other site 158190000586 4Fe-4S binding domain; Region: Fer4_5; pfam12801 158190000587 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190000588 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190000589 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190000590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190000591 active site 158190000592 phosphorylation site [posttranslational modification] 158190000593 intermolecular recognition site; other site 158190000594 dimerization interface [polypeptide binding]; other site 158190000595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190000596 DNA binding site [nucleotide binding] 158190000597 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190000598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190000599 dimer interface [polypeptide binding]; other site 158190000600 phosphorylation site [posttranslational modification] 158190000601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190000602 ATP binding site [chemical binding]; other site 158190000603 Mg2+ binding site [ion binding]; other site 158190000604 G-X-G motif; other site 158190000605 Protein of unknown function (DUF969); Region: DUF969; pfam06149 158190000606 Predicted membrane protein [Function unknown]; Region: COG3817 158190000607 Protein of unknown function (DUF979); Region: DUF979; pfam06166 158190000608 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 158190000609 putative substrate binding pocket [chemical binding]; other site 158190000610 AC domain interface; other site 158190000611 catalytic triad [active] 158190000612 AB domain interface; other site 158190000613 interchain disulfide; other site 158190000614 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 158190000615 putative active site pocket [active] 158190000616 dimerization interface [polypeptide binding]; other site 158190000617 putative catalytic residue [active] 158190000618 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 158190000619 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 158190000620 putative dimer interface [polypeptide binding]; other site 158190000621 [2Fe-2S] cluster binding site [ion binding]; other site 158190000622 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 158190000623 dimer interface [polypeptide binding]; other site 158190000624 [2Fe-2S] cluster binding site [ion binding]; other site 158190000625 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 158190000626 SLBB domain; Region: SLBB; pfam10531 158190000627 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 158190000628 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 158190000629 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158190000630 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 158190000631 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 158190000632 catalytic loop [active] 158190000633 iron binding site [ion binding]; other site 158190000634 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 158190000635 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 158190000636 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158190000637 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 158190000638 membrane protein FdrA; Validated; Region: PRK06091 158190000639 CoA binding domain; Region: CoA_binding; pfam02629 158190000640 CoA-ligase; Region: Ligase_CoA; pfam00549 158190000641 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 158190000642 Putative cyclase; Region: Cyclase; cl00814 158190000643 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 158190000644 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 158190000645 active site 158190000646 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 158190000647 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 158190000648 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158190000649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190000650 DNA-binding site [nucleotide binding]; DNA binding site 158190000651 FCD domain; Region: FCD; pfam07729 158190000652 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 158190000653 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 158190000654 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 158190000655 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 158190000656 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 158190000657 catalytic loop [active] 158190000658 iron binding site [ion binding]; other site 158190000659 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158190000660 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 158190000661 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158190000662 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190000663 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 158190000664 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158190000665 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190000666 substrate binding pocket [chemical binding]; other site 158190000667 membrane-bound complex binding site; other site 158190000668 hinge residues; other site 158190000669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000670 dimer interface [polypeptide binding]; other site 158190000671 conserved gate region; other site 158190000672 putative PBP binding loops; other site 158190000673 ABC-ATPase subunit interface; other site 158190000674 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158190000675 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158190000676 Walker A/P-loop; other site 158190000677 ATP binding site [chemical binding]; other site 158190000678 Q-loop/lid; other site 158190000679 ABC transporter signature motif; other site 158190000680 Walker B; other site 158190000681 D-loop; other site 158190000682 H-loop/switch region; other site 158190000683 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190000684 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190000685 metal binding site [ion binding]; metal-binding site 158190000686 active site 158190000687 I-site; other site 158190000688 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158190000689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190000690 catalytic residue [active] 158190000691 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 158190000692 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158190000693 inhibitor-cofactor binding pocket; inhibition site 158190000694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190000695 catalytic residue [active] 158190000696 Peptidase family C69; Region: Peptidase_C69; cl17793 158190000697 Predicted membrane protein [Function unknown]; Region: COG2364 158190000698 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 158190000699 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 158190000700 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158190000701 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 158190000702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190000703 FeS/SAM binding site; other site 158190000704 FMN-binding domain; Region: FMN_bind; cl01081 158190000705 Cna protein B-type domain; Region: Cna_B_2; pfam13715 158190000706 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 158190000707 HNH endonuclease; Region: HNH_2; pfam13391 158190000708 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190000709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190000710 non-specific DNA binding site [nucleotide binding]; other site 158190000711 salt bridge; other site 158190000712 sequence-specific DNA binding site [nucleotide binding]; other site 158190000713 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 158190000714 homodimer interface [polypeptide binding]; other site 158190000715 chemical substrate binding site [chemical binding]; other site 158190000716 oligomer interface [polypeptide binding]; other site 158190000717 metal binding site [ion binding]; metal-binding site 158190000718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190000719 Walker A motif; other site 158190000720 ATP binding site [chemical binding]; other site 158190000721 Walker B motif; other site 158190000722 arginine finger; other site 158190000723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190000724 putative substrate translocation pore; other site 158190000725 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190000726 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190000727 Zn2+ binding site [ion binding]; other site 158190000728 Mg2+ binding site [ion binding]; other site 158190000729 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 158190000730 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 158190000731 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 158190000732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190000733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000734 dimer interface [polypeptide binding]; other site 158190000735 conserved gate region; other site 158190000736 putative PBP binding loops; other site 158190000737 ABC-ATPase subunit interface; other site 158190000738 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190000739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000740 dimer interface [polypeptide binding]; other site 158190000741 conserved gate region; other site 158190000742 putative PBP binding loops; other site 158190000743 ABC-ATPase subunit interface; other site 158190000744 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190000745 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158190000746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190000747 active site 158190000748 phosphorylation site [posttranslational modification] 158190000749 intermolecular recognition site; other site 158190000750 dimerization interface [polypeptide binding]; other site 158190000751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158190000752 DNA binding residues [nucleotide binding] 158190000753 dimerization interface [polypeptide binding]; other site 158190000754 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190000755 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190000756 ligand binding site [chemical binding]; other site 158190000757 dimerization interface [polypeptide binding]; other site 158190000758 GAF domain; Region: GAF_3; pfam13492 158190000759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190000760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190000761 ATP binding site [chemical binding]; other site 158190000762 Mg2+ binding site [ion binding]; other site 158190000763 G-X-G motif; other site 158190000764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 158190000765 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 158190000766 putative FMN binding site [chemical binding]; other site 158190000767 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 158190000768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 158190000769 dimerization interface [polypeptide binding]; other site 158190000770 putative DNA binding site [nucleotide binding]; other site 158190000771 putative Zn2+ binding site [ion binding]; other site 158190000772 Protein of unknown function DUF72; Region: DUF72; pfam01904 158190000773 DNA polymerase IV; Validated; Region: PRK01810 158190000774 Y-family of DNA polymerases; Region: PolY; cl12025 158190000775 active site 158190000776 DNA binding site [nucleotide binding] 158190000777 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 158190000778 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 158190000779 active site 158190000780 PHP Thumb interface [polypeptide binding]; other site 158190000781 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 158190000782 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 158190000783 generic binding surface I; other site 158190000784 generic binding surface II; other site 158190000785 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 158190000786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190000787 Coenzyme A binding pocket [chemical binding]; other site 158190000788 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 158190000789 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 158190000790 putative NAD(P) binding site [chemical binding]; other site 158190000791 dimer interface [polypeptide binding]; other site 158190000792 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 158190000793 FAD binding pocket [chemical binding]; other site 158190000794 conserved FAD binding motif [chemical binding]; other site 158190000795 phosphate binding motif [ion binding]; other site 158190000796 beta-alpha-beta structure motif; other site 158190000797 NAD binding pocket [chemical binding]; other site 158190000798 Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616 158190000799 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158190000800 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158190000801 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158190000802 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158190000803 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 158190000804 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 158190000805 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190000806 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190000807 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190000808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190000809 Walker A/P-loop; other site 158190000810 ATP binding site [chemical binding]; other site 158190000811 Q-loop/lid; other site 158190000812 ABC transporter signature motif; other site 158190000813 Walker B; other site 158190000814 D-loop; other site 158190000815 H-loop/switch region; other site 158190000816 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190000817 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190000818 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190000819 TM-ABC transporter signature motif; other site 158190000820 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190000821 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190000822 TM-ABC transporter signature motif; other site 158190000823 CAAX protease self-immunity; Region: Abi; pfam02517 158190000824 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158190000825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190000826 NAD(P) binding site [chemical binding]; other site 158190000827 active site 158190000828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190000829 NADH(P)-binding; Region: NAD_binding_10; pfam13460 158190000830 NAD(P) binding site [chemical binding]; other site 158190000831 active site 158190000832 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 158190000833 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 158190000834 CAAX protease self-immunity; Region: Abi; pfam02517 158190000835 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158190000836 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 158190000837 Walker A/P-loop; other site 158190000838 ATP binding site [chemical binding]; other site 158190000839 Q-loop/lid; other site 158190000840 ABC transporter signature motif; other site 158190000841 Walker B; other site 158190000842 D-loop; other site 158190000843 H-loop/switch region; other site 158190000844 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 158190000845 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 158190000846 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 158190000847 helicase 45; Provisional; Region: PTZ00424 158190000848 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 158190000849 ATP binding site [chemical binding]; other site 158190000850 Mg++ binding site [ion binding]; other site 158190000851 motif III; other site 158190000852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190000853 nucleotide binding region [chemical binding]; other site 158190000854 ATP-binding site [chemical binding]; other site 158190000855 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 158190000856 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190000857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190000858 metal binding site [ion binding]; metal-binding site 158190000859 active site 158190000860 I-site; other site 158190000861 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 158190000862 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 158190000863 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190000864 active site 158190000865 metal binding site [ion binding]; metal-binding site 158190000866 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 158190000867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 158190000868 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 158190000869 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 158190000870 Helix-turn-helix domain; Region: HTH_18; pfam12833 158190000871 Cupin domain; Region: Cupin_2; pfam07883 158190000872 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 158190000873 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 158190000874 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 158190000875 active site 158190000876 FMN binding site [chemical binding]; other site 158190000877 substrate binding site [chemical binding]; other site 158190000878 putative catalytic residue [active] 158190000879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190000880 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 158190000881 NAD(P) binding site [chemical binding]; other site 158190000882 active site 158190000883 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 158190000884 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 158190000885 C-terminal domain interface [polypeptide binding]; other site 158190000886 sugar binding site [chemical binding]; other site 158190000887 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190000888 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 158190000889 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158190000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190000891 S-adenosylmethionine binding site [chemical binding]; other site 158190000892 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 158190000893 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 158190000894 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 158190000895 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 158190000896 putative active site; other site 158190000897 putative metal binding residues [ion binding]; other site 158190000898 signature motif; other site 158190000899 putative triphosphate binding site [ion binding]; other site 158190000900 Domain of unknown function (DUF336); Region: DUF336; cl01249 158190000901 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190000902 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190000903 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158190000904 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158190000905 putative acyl-acceptor binding pocket; other site 158190000906 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158190000907 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 158190000908 Walker A/P-loop; other site 158190000909 ATP binding site [chemical binding]; other site 158190000910 Q-loop/lid; other site 158190000911 ABC transporter signature motif; other site 158190000912 Walker B; other site 158190000913 D-loop; other site 158190000914 H-loop/switch region; other site 158190000915 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 158190000916 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158190000917 ABC-ATPase subunit interface; other site 158190000918 dimer interface [polypeptide binding]; other site 158190000919 putative PBP binding regions; other site 158190000920 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 158190000921 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 158190000922 putative binding site residues; other site 158190000923 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 158190000924 RNA/DNA hybrid binding site [nucleotide binding]; other site 158190000925 active site 158190000926 Chromate transporter; Region: Chromate_transp; pfam02417 158190000927 Chromate transporter; Region: Chromate_transp; pfam02417 158190000928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190000929 binding surface 158190000930 TPR motif; other site 158190000931 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158190000932 active site 158190000933 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190000934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000935 dimer interface [polypeptide binding]; other site 158190000936 conserved gate region; other site 158190000937 putative PBP binding loops; other site 158190000938 ABC-ATPase subunit interface; other site 158190000939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000940 dimer interface [polypeptide binding]; other site 158190000941 conserved gate region; other site 158190000942 ABC-ATPase subunit interface; other site 158190000943 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190000944 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190000945 adenylate kinase; Reviewed; Region: adk; PRK00279 158190000946 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 158190000947 AMP-binding site [chemical binding]; other site 158190000948 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 158190000949 4-alpha-glucanotransferase; Provisional; Region: PRK14508 158190000950 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190000951 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190000952 DNA binding site [nucleotide binding] 158190000953 domain linker motif; other site 158190000954 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190000955 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 158190000956 trehalose synthase; Region: treS_nterm; TIGR02456 158190000957 active site 158190000958 catalytic site [active] 158190000959 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 158190000960 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 158190000961 active site 158190000962 homodimer interface [polypeptide binding]; other site 158190000963 catalytic site [active] 158190000964 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190000965 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190000966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000967 dimer interface [polypeptide binding]; other site 158190000968 conserved gate region; other site 158190000969 putative PBP binding loops; other site 158190000970 ABC-ATPase subunit interface; other site 158190000971 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190000972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190000973 dimer interface [polypeptide binding]; other site 158190000974 conserved gate region; other site 158190000975 putative PBP binding loops; other site 158190000976 ABC-ATPase subunit interface; other site 158190000977 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 158190000978 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190000979 putative DNA binding site [nucleotide binding]; other site 158190000980 putative Zn2+ binding site [ion binding]; other site 158190000981 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190000982 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158190000983 Uncharacterized conserved protein [Function unknown]; Region: COG5476 158190000984 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 158190000985 MlrC C-terminus; Region: MlrC_C; pfam07171 158190000986 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 158190000987 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158190000988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 158190000989 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 158190000990 active site 158190000991 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 158190000992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190000993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190000994 metal binding site [ion binding]; metal-binding site 158190000995 active site 158190000996 I-site; other site 158190000997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190000998 metal binding site [ion binding]; metal-binding site 158190000999 active site 158190001000 I-site; other site 158190001001 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158190001002 Predicted membrane protein [Function unknown]; Region: COG4905 158190001003 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 158190001004 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 158190001005 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158190001006 catalytic residue [active] 158190001007 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 158190001008 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158190001009 active site 158190001010 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 158190001011 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 158190001012 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 158190001013 GTPase RsgA; Reviewed; Region: PRK00098 158190001014 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 158190001015 RNA binding site [nucleotide binding]; other site 158190001016 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 158190001017 GTPase/Zn-binding domain interface [polypeptide binding]; other site 158190001018 GTP/Mg2+ binding site [chemical binding]; other site 158190001019 G4 box; other site 158190001020 G5 box; other site 158190001021 G1 box; other site 158190001022 Switch I region; other site 158190001023 G2 box; other site 158190001024 G3 box; other site 158190001025 Switch II region; other site 158190001026 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 158190001027 MutS domain III; Region: MutS_III; pfam05192 158190001028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190001029 Walker A/P-loop; other site 158190001030 ATP binding site [chemical binding]; other site 158190001031 Q-loop/lid; other site 158190001032 ABC transporter signature motif; other site 158190001033 Walker B; other site 158190001034 D-loop; other site 158190001035 H-loop/switch region; other site 158190001036 Smr domain; Region: Smr; pfam01713 158190001037 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 158190001038 GIY-YIG motif/motif A; other site 158190001039 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 158190001040 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158190001041 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 158190001042 GIY-YIG motif/motif A; other site 158190001043 active site 158190001044 catalytic site [active] 158190001045 V-type ATP synthase subunit E; Provisional; Region: PRK01558 158190001046 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 158190001047 V-type ATP synthase subunit A; Provisional; Region: PRK04192 158190001048 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158190001049 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 158190001050 Walker A motif/ATP binding site; other site 158190001051 Walker B motif; other site 158190001052 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 158190001053 V-type ATP synthase subunit B; Provisional; Region: PRK02118 158190001054 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158190001055 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 158190001056 Walker A motif homologous position; other site 158190001057 Walker B motif; other site 158190001058 V-type ATP synthase subunit D; Provisional; Region: PRK02195 158190001059 V-type ATP synthase subunit I; Validated; Region: PRK05771 158190001060 V-type ATP synthase subunit K; Validated; Region: PRK06649 158190001061 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 158190001062 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 158190001063 DNA binding site [nucleotide binding] 158190001064 active site 158190001065 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 158190001066 dimer interface [polypeptide binding]; other site 158190001067 FMN binding site [chemical binding]; other site 158190001068 Domain of unknown function (DUF386); Region: DUF386; cl01047 158190001069 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 158190001070 GcpE protein; Region: GcpE; pfam04551 158190001071 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 158190001072 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 158190001073 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 158190001074 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 158190001075 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 158190001076 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 158190001077 PhoH-like protein; Region: PhoH; pfam02562 158190001078 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 158190001079 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 158190001080 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190001081 Zn2+ binding site [ion binding]; other site 158190001082 Mg2+ binding site [ion binding]; other site 158190001083 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 158190001084 FOG: CBS domain [General function prediction only]; Region: COG0517 158190001085 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 158190001086 Transporter associated domain; Region: CorC_HlyC; smart01091 158190001087 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 158190001088 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 158190001089 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 158190001090 Phosphoglycerate kinase; Region: PGK; pfam00162 158190001091 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 158190001092 substrate binding site [chemical binding]; other site 158190001093 hinge regions; other site 158190001094 ADP binding site [chemical binding]; other site 158190001095 catalytic site [active] 158190001096 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 158190001097 triosephosphate isomerase; Provisional; Region: PRK14567 158190001098 substrate binding site [chemical binding]; other site 158190001099 dimer interface [polypeptide binding]; other site 158190001100 catalytic triad [active] 158190001101 Preprotein translocase SecG subunit; Region: SecG; pfam03840 158190001102 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158190001103 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 158190001104 SurA N-terminal domain; Region: SurA_N_3; cl07813 158190001105 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 158190001106 transcription antitermination factor NusB; Region: nusB; TIGR01951 158190001107 putative RNA binding site [nucleotide binding]; other site 158190001108 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 158190001109 active site 158190001110 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 158190001111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158190001112 active site 158190001113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190001114 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 158190001115 putative ADP-binding pocket [chemical binding]; other site 158190001116 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 158190001117 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 158190001118 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 158190001119 homodimer interface [polypeptide binding]; other site 158190001120 NADP binding site [chemical binding]; other site 158190001121 substrate binding site [chemical binding]; other site 158190001122 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14335 158190001123 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 158190001124 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190001125 FeS/SAM binding site; other site 158190001126 Suppression of tumorigenicity 7; Region: ST7; cd11557 158190001127 Cupin domain; Region: Cupin_2; cl17218 158190001128 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 158190001129 active site 158190001130 catalytic residues [active] 158190001131 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 158190001132 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 158190001133 DXD motif; other site 158190001134 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 158190001135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158190001136 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190001137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190001138 metal binding site [ion binding]; metal-binding site 158190001139 active site 158190001140 I-site; other site 158190001141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190001142 Response regulator receiver domain; Region: Response_reg; pfam00072 158190001143 active site 158190001144 phosphorylation site [posttranslational modification] 158190001145 intermolecular recognition site; other site 158190001146 dimerization interface [polypeptide binding]; other site 158190001147 NAD-dependent deacetylase; Provisional; Region: PRK00481 158190001148 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 158190001149 NAD+ binding site [chemical binding]; other site 158190001150 substrate binding site [chemical binding]; other site 158190001151 Zn binding site [ion binding]; other site 158190001152 Response regulator receiver domain; Region: Response_reg; pfam00072 158190001153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190001154 active site 158190001155 phosphorylation site [posttranslational modification] 158190001156 intermolecular recognition site; other site 158190001157 dimerization interface [polypeptide binding]; other site 158190001158 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190001159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190001160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 158190001161 Histidine kinase; Region: His_kinase; pfam06580 158190001162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190001163 ATP binding site [chemical binding]; other site 158190001164 Mg2+ binding site [ion binding]; other site 158190001165 G-X-G motif; other site 158190001166 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190001167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190001168 Walker A/P-loop; other site 158190001169 ATP binding site [chemical binding]; other site 158190001170 Q-loop/lid; other site 158190001171 ABC transporter signature motif; other site 158190001172 Walker B; other site 158190001173 H-loop/switch region; other site 158190001174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190001175 Walker A/P-loop; other site 158190001176 ATP binding site [chemical binding]; other site 158190001177 Q-loop/lid; other site 158190001178 ABC transporter signature motif; other site 158190001179 Walker B; other site 158190001180 D-loop; other site 158190001181 H-loop/switch region; other site 158190001182 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190001183 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190001184 Walker A/P-loop; other site 158190001185 ATP binding site [chemical binding]; other site 158190001186 Q-loop/lid; other site 158190001187 ABC transporter signature motif; other site 158190001188 Walker B; other site 158190001189 D-loop; other site 158190001190 H-loop/switch region; other site 158190001191 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190001192 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190001193 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190001194 TM-ABC transporter signature motif; other site 158190001195 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158190001196 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 158190001197 putative ligand binding site [chemical binding]; other site 158190001198 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 158190001199 Carbon starvation protein CstA; Region: CstA; pfam02554 158190001200 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 158190001201 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 158190001202 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158190001203 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 158190001204 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 158190001205 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 158190001206 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 158190001207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190001208 NAD(P) binding site [chemical binding]; other site 158190001209 active site 158190001210 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 158190001211 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 158190001212 transmembrane helices; other site 158190001213 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 158190001214 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 158190001215 EamA-like transporter family; Region: EamA; pfam00892 158190001216 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 158190001217 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 158190001218 active site 158190001219 catalytic residues [active] 158190001220 DNA binding site [nucleotide binding] 158190001221 Int/Topo IB signature motif; other site 158190001222 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 158190001223 SmpB-tmRNA interface; other site 158190001224 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 158190001225 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 158190001226 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 158190001227 Catalytic site [active] 158190001228 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 158190001229 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 158190001230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190001231 FeS/SAM binding site; other site 158190001232 HemN C-terminal domain; Region: HemN_C; pfam06969 158190001233 hypothetical protein; Validated; Region: PRK00110 158190001234 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 158190001235 active site 158190001236 putative DNA-binding cleft [nucleotide binding]; other site 158190001237 dimer interface [polypeptide binding]; other site 158190001238 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 158190001239 RuvA N terminal domain; Region: RuvA_N; pfam01330 158190001240 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 158190001241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190001242 Walker A motif; other site 158190001243 ATP binding site [chemical binding]; other site 158190001244 Walker B motif; other site 158190001245 arginine finger; other site 158190001246 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 158190001247 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 158190001248 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 158190001249 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 158190001250 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 158190001251 TMP-binding site; other site 158190001252 ATP-binding site [chemical binding]; other site 158190001253 Family of unknown function (DUF490); Region: DUF490; pfam04357 158190001254 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 158190001255 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 158190001256 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 158190001257 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 158190001258 Surface antigen; Region: Bac_surface_Ag; pfam01103 158190001259 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 158190001260 MutS domain I; Region: MutS_I; pfam01624 158190001261 MutS domain II; Region: MutS_II; pfam05188 158190001262 MutS domain III; Region: MutS_III; pfam05192 158190001263 MutS domain V; Region: MutS_V; pfam00488 158190001264 Walker A/P-loop; other site 158190001265 ATP binding site [chemical binding]; other site 158190001266 Q-loop/lid; other site 158190001267 ABC transporter signature motif; other site 158190001268 Walker B; other site 158190001269 D-loop; other site 158190001270 H-loop/switch region; other site 158190001271 comF family protein; Region: comF; TIGR00201 158190001272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158190001273 active site 158190001274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 158190001275 Sm and related proteins; Region: Sm_like; cl00259 158190001276 heptamer interface [polypeptide binding]; other site 158190001277 Sm1 motif; other site 158190001278 hexamer interface [polypeptide binding]; other site 158190001279 RNA binding site [nucleotide binding]; other site 158190001280 Sm2 motif; other site 158190001281 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 158190001282 NusA N-terminal domain; Region: NusA_N; pfam08529 158190001283 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 158190001284 RNA binding site [nucleotide binding]; other site 158190001285 homodimer interface [polypeptide binding]; other site 158190001286 NusA-like KH domain; Region: KH_5; pfam13184 158190001287 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 158190001288 G-X-X-G motif; other site 158190001289 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 158190001290 Double zinc ribbon; Region: DZR; pfam12773 158190001291 translation initiation factor IF-2; Region: IF-2; TIGR00487 158190001292 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 158190001293 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 158190001294 G1 box; other site 158190001295 putative GEF interaction site [polypeptide binding]; other site 158190001296 GTP/Mg2+ binding site [chemical binding]; other site 158190001297 Switch I region; other site 158190001298 G2 box; other site 158190001299 G3 box; other site 158190001300 Switch II region; other site 158190001301 G4 box; other site 158190001302 G5 box; other site 158190001303 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 158190001304 Translation-initiation factor 2; Region: IF-2; pfam11987 158190001305 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 158190001306 Ribosome-binding factor A; Region: RBFA; pfam02033 158190001307 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 158190001308 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 158190001309 RNA binding site [nucleotide binding]; other site 158190001310 active site 158190001311 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 158190001312 active site 158190001313 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 158190001314 16S/18S rRNA binding site [nucleotide binding]; other site 158190001315 S13e-L30e interaction site [polypeptide binding]; other site 158190001316 25S rRNA binding site [nucleotide binding]; other site 158190001317 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 158190001318 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 158190001319 RNase E interface [polypeptide binding]; other site 158190001320 trimer interface [polypeptide binding]; other site 158190001321 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 158190001322 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 158190001323 RNase E interface [polypeptide binding]; other site 158190001324 trimer interface [polypeptide binding]; other site 158190001325 active site 158190001326 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 158190001327 putative nucleic acid binding region [nucleotide binding]; other site 158190001328 G-X-X-G motif; other site 158190001329 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 158190001330 RNA binding site [nucleotide binding]; other site 158190001331 domain interface; other site 158190001332 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 158190001333 trimer interface [polypeptide binding]; other site 158190001334 active site 158190001335 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 158190001336 Predicted permeases [General function prediction only]; Region: COG0795 158190001337 Predicted permeases [General function prediction only]; Region: COG0795 158190001338 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 158190001339 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 158190001340 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 158190001341 integral membrane protein MviN; Region: mviN; TIGR01695 158190001342 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 158190001343 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 158190001344 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 158190001345 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 158190001346 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 158190001347 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 158190001348 substrate binding site [chemical binding]; other site 158190001349 hexamer interface [polypeptide binding]; other site 158190001350 metal binding site [ion binding]; metal-binding site 158190001351 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 158190001352 putative active site [active] 158190001353 dimerization interface [polypeptide binding]; other site 158190001354 putative tRNAtyr binding site [nucleotide binding]; other site 158190001355 recombinase A; Provisional; Region: recA; PRK09354 158190001356 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 158190001357 hexamer interface [polypeptide binding]; other site 158190001358 Walker A motif; other site 158190001359 ATP binding site [chemical binding]; other site 158190001360 Walker B motif; other site 158190001361 ScpA/B protein; Region: ScpA_ScpB; cl00598 158190001362 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 158190001363 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 158190001364 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158190001365 RNA binding surface [nucleotide binding]; other site 158190001366 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 158190001367 active site 158190001368 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 158190001369 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 158190001370 CMP-binding site; other site 158190001371 The sites determining sugar specificity; other site 158190001372 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 158190001373 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 158190001374 RNA binding site [nucleotide binding]; other site 158190001375 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 158190001376 RNA binding site [nucleotide binding]; other site 158190001377 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 158190001378 RNA binding site [nucleotide binding]; other site 158190001379 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 158190001380 RNA binding site [nucleotide binding]; other site 158190001381 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 158190001382 RNA binding site [nucleotide binding]; other site 158190001383 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 158190001384 RNA binding site [nucleotide binding]; other site 158190001385 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 158190001386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 158190001387 binding surface 158190001388 TPR motif; other site 158190001389 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 158190001390 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 158190001391 glutaminase active site [active] 158190001392 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 158190001393 dimer interface [polypeptide binding]; other site 158190001394 active site 158190001395 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 158190001396 dimer interface [polypeptide binding]; other site 158190001397 active site 158190001398 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 158190001399 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158190001400 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158190001401 Walker A/P-loop; other site 158190001402 ATP binding site [chemical binding]; other site 158190001403 Q-loop/lid; other site 158190001404 ABC transporter signature motif; other site 158190001405 Walker B; other site 158190001406 D-loop; other site 158190001407 H-loop/switch region; other site 158190001408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190001409 DNA-binding site [nucleotide binding]; DNA binding site 158190001410 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 158190001411 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 158190001412 homodimer interface [polypeptide binding]; other site 158190001413 metal binding site [ion binding]; metal-binding site 158190001414 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 158190001415 homodimer interface [polypeptide binding]; other site 158190001416 active site 158190001417 putative chemical substrate binding site [chemical binding]; other site 158190001418 metal binding site [ion binding]; metal-binding site 158190001419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190001420 DNA-binding site [nucleotide binding]; DNA binding site 158190001421 TrkA-C domain; Region: TrkA_C; pfam02080 158190001422 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 158190001423 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 158190001424 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158190001425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001426 dimer interface [polypeptide binding]; other site 158190001427 conserved gate region; other site 158190001428 putative PBP binding loops; other site 158190001429 ABC-ATPase subunit interface; other site 158190001430 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 158190001431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001432 dimer interface [polypeptide binding]; other site 158190001433 conserved gate region; other site 158190001434 putative PBP binding loops; other site 158190001435 ABC-ATPase subunit interface; other site 158190001436 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 158190001437 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158190001438 Walker A/P-loop; other site 158190001439 ATP binding site [chemical binding]; other site 158190001440 Q-loop/lid; other site 158190001441 ABC transporter signature motif; other site 158190001442 Walker B; other site 158190001443 D-loop; other site 158190001444 H-loop/switch region; other site 158190001445 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 158190001446 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158190001447 Walker A/P-loop; other site 158190001448 ATP binding site [chemical binding]; other site 158190001449 Q-loop/lid; other site 158190001450 ABC transporter signature motif; other site 158190001451 Walker B; other site 158190001452 D-loop; other site 158190001453 H-loop/switch region; other site 158190001454 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158190001455 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 158190001456 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 158190001457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190001458 FeS/SAM binding site; other site 158190001459 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 158190001460 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 158190001461 Putative zinc ribbon domain; Region: DUF164; pfam02591 158190001462 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 158190001463 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 158190001464 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 158190001465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 158190001466 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 158190001467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158190001468 DNA binding residues [nucleotide binding] 158190001469 DNA primase; Validated; Region: dnaG; PRK05667 158190001470 CHC2 zinc finger; Region: zf-CHC2; pfam01807 158190001471 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 158190001472 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 158190001473 active site 158190001474 metal binding site [ion binding]; metal-binding site 158190001475 interdomain interaction site; other site 158190001476 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 158190001477 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 158190001478 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cl10037 158190001479 homotrimer interaction site [polypeptide binding]; other site 158190001480 active site 158190001481 Thiamine pyrophosphokinase; Region: TPK; cd07995 158190001482 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 158190001483 active site 158190001484 dimerization interface [polypeptide binding]; other site 158190001485 thiamine binding site [chemical binding]; other site 158190001486 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 158190001487 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 158190001488 ribonuclease Z; Region: RNase_Z; TIGR02651 158190001489 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158190001490 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158190001491 FtsX-like permease family; Region: FtsX; pfam02687 158190001492 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158190001493 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158190001494 Walker A/P-loop; other site 158190001495 ATP binding site [chemical binding]; other site 158190001496 Q-loop/lid; other site 158190001497 ABC transporter signature motif; other site 158190001498 Walker B; other site 158190001499 D-loop; other site 158190001500 H-loop/switch region; other site 158190001501 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158190001502 FtsX-like permease family; Region: FtsX; pfam02687 158190001503 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 158190001504 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158190001505 peptide chain release factor 2; Validated; Region: prfB; PRK00578 158190001506 This domain is found in peptide chain release factors; Region: PCRF; smart00937 158190001507 RF-1 domain; Region: RF-1; pfam00472 158190001508 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 158190001509 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 158190001510 ferredoxin; Validated; Region: PRK07118 158190001511 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 158190001512 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 158190001513 electron transport complex RsxE subunit; Provisional; Region: PRK12405 158190001514 FMN-binding domain; Region: FMN_bind; cl01081 158190001515 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 158190001516 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 158190001517 SLBB domain; Region: SLBB; pfam10531 158190001518 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190001519 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 158190001520 active site 158190001521 NTP binding site [chemical binding]; other site 158190001522 metal binding triad [ion binding]; metal-binding site 158190001523 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 158190001524 histidyl-tRNA synthetase; Region: hisS; TIGR00442 158190001525 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 158190001526 dimer interface [polypeptide binding]; other site 158190001527 motif 1; other site 158190001528 active site 158190001529 motif 2; other site 158190001530 motif 3; other site 158190001531 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 158190001532 anticodon binding site; other site 158190001533 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158190001534 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190001535 ATP binding site [chemical binding]; other site 158190001536 putative Mg++ binding site [ion binding]; other site 158190001537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190001538 nucleotide binding region [chemical binding]; other site 158190001539 ATP-binding site [chemical binding]; other site 158190001540 Helicase associated domain (HA2); Region: HA2; pfam04408 158190001541 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 158190001542 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 158190001543 active site 158190001544 dimer interface [polypeptide binding]; other site 158190001545 metal binding site [ion binding]; metal-binding site 158190001546 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 158190001547 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 158190001548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190001549 catalytic residue [active] 158190001550 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 158190001551 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 158190001552 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 158190001553 Ligand Binding Site [chemical binding]; other site 158190001554 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190001555 nucleotide binding site [chemical binding]; other site 158190001556 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 158190001557 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 158190001558 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 158190001559 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 158190001560 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 158190001561 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 158190001562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 158190001563 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 158190001564 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 158190001565 active site 158190001566 substrate binding site [chemical binding]; other site 158190001567 metal binding site [ion binding]; metal-binding site 158190001568 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 158190001569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190001570 Walker A/P-loop; other site 158190001571 ATP binding site [chemical binding]; other site 158190001572 Q-loop/lid; other site 158190001573 ABC transporter signature motif; other site 158190001574 Walker B; other site 158190001575 D-loop; other site 158190001576 H-loop/switch region; other site 158190001577 TOBE domain; Region: TOBE_2; pfam08402 158190001578 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190001579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001580 dimer interface [polypeptide binding]; other site 158190001581 conserved gate region; other site 158190001582 putative PBP binding loops; other site 158190001583 ABC-ATPase subunit interface; other site 158190001584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001585 dimer interface [polypeptide binding]; other site 158190001586 conserved gate region; other site 158190001587 putative PBP binding loops; other site 158190001588 ABC-ATPase subunit interface; other site 158190001589 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158190001590 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158190001591 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 158190001592 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 158190001593 active site 158190001594 HIGH motif; other site 158190001595 dimer interface [polypeptide binding]; other site 158190001596 KMSKS motif; other site 158190001597 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 158190001598 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 158190001599 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 158190001600 HIGH motif; other site 158190001601 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 158190001602 active site 158190001603 KMSKS motif; other site 158190001604 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 158190001605 tRNA binding surface [nucleotide binding]; other site 158190001606 anticodon binding site; other site 158190001607 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 158190001608 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 158190001609 active site 158190001610 NTP binding site [chemical binding]; other site 158190001611 metal binding triad [ion binding]; metal-binding site 158190001612 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 158190001613 HD domain; Region: HD; pfam01966 158190001614 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 158190001615 ribonuclease III; Reviewed; Region: rnc; PRK00102 158190001616 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 158190001617 dimerization interface [polypeptide binding]; other site 158190001618 active site 158190001619 metal binding site [ion binding]; metal-binding site 158190001620 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 158190001621 dsRNA binding site [nucleotide binding]; other site 158190001622 acyl carrier protein; Provisional; Region: acpP; PRK00982 158190001623 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 158190001624 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 158190001625 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 158190001626 active site 158190001627 (T/H)XGH motif; other site 158190001628 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 158190001629 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 158190001630 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 158190001631 RimM N-terminal domain; Region: RimM; pfam01782 158190001632 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 158190001633 hypothetical protein; Provisional; Region: PRK00468 158190001634 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 158190001635 signal recognition particle protein; Provisional; Region: PRK10867 158190001636 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 158190001637 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 158190001638 P loop; other site 158190001639 GTP binding site [chemical binding]; other site 158190001640 Signal peptide binding domain; Region: SRP_SPB; pfam02978 158190001641 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 158190001642 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 158190001643 Walker A/P-loop; other site 158190001644 ATP binding site [chemical binding]; other site 158190001645 Q-loop/lid; other site 158190001646 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 158190001647 Q-loop/lid; other site 158190001648 ABC transporter signature motif; other site 158190001649 Walker B; other site 158190001650 D-loop; other site 158190001651 H-loop/switch region; other site 158190001652 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 158190001653 RNA/DNA hybrid binding site [nucleotide binding]; other site 158190001654 active site 158190001655 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 158190001656 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 158190001657 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 158190001658 EamA-like transporter family; Region: EamA; pfam00892 158190001659 EamA-like transporter family; Region: EamA; pfam00892 158190001660 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158190001661 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190001662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190001663 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 158190001664 Sulfatase; Region: Sulfatase; cl17466 158190001665 Sulfatase; Region: Sulfatase; cl17466 158190001666 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 158190001667 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190001668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001669 dimer interface [polypeptide binding]; other site 158190001670 conserved gate region; other site 158190001671 putative PBP binding loops; other site 158190001672 ABC-ATPase subunit interface; other site 158190001673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001674 dimer interface [polypeptide binding]; other site 158190001675 conserved gate region; other site 158190001676 putative PBP binding loops; other site 158190001677 ABC-ATPase subunit interface; other site 158190001678 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190001679 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190001680 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 158190001681 Sulfatase; Region: Sulfatase; pfam00884 158190001682 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158190001683 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158190001684 ligand binding site [chemical binding]; other site 158190001685 flexible hinge region; other site 158190001686 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 158190001687 non-specific DNA interactions [nucleotide binding]; other site 158190001688 DNA binding site [nucleotide binding] 158190001689 sequence specific DNA binding site [nucleotide binding]; other site 158190001690 putative cAMP binding site [chemical binding]; other site 158190001691 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 158190001692 Carbon starvation protein CstA; Region: CstA; pfam02554 158190001693 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 158190001694 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 158190001695 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 158190001696 DTAP/Switch II; other site 158190001697 Switch I; other site 158190001698 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 158190001699 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 158190001700 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 158190001701 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 158190001702 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190001703 nucleotide binding site [chemical binding]; other site 158190001704 Type III pantothenate kinase; Region: Pan_kinase; cl17198 158190001705 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 158190001706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190001707 Walker A/P-loop; other site 158190001708 ATP binding site [chemical binding]; other site 158190001709 Q-loop/lid; other site 158190001710 ABC transporter signature motif; other site 158190001711 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158190001712 Walker B; other site 158190001713 D-loop; other site 158190001714 H-loop/switch region; other site 158190001715 ABC transporter; Region: ABC_tran_2; pfam12848 158190001716 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158190001717 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158190001718 active site 158190001719 UGMP family protein; Validated; Region: PRK09604 158190001720 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190001721 nucleotide binding site [chemical binding]; other site 158190001722 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158190001723 Propionate catabolism activator; Region: PrpR_N; pfam06506 158190001724 PAS domain; Region: PAS; smart00091 158190001725 putative active site [active] 158190001726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 158190001727 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 158190001728 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 158190001729 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 158190001730 metal binding site [ion binding]; metal-binding site 158190001731 substrate binding pocket [chemical binding]; other site 158190001732 Uncharacterized conserved protein [Function unknown]; Region: COG2006 158190001733 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 158190001734 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158190001735 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 158190001736 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 158190001737 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158190001738 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158190001739 inhibitor site; inhibition site 158190001740 active site 158190001741 dimer interface [polypeptide binding]; other site 158190001742 catalytic residue [active] 158190001743 galactarate dehydratase; Region: galactar-dH20; TIGR03248 158190001744 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 158190001745 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 158190001746 pyruvate phosphate dikinase; Provisional; Region: PRK09279 158190001747 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 158190001748 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 158190001749 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 158190001750 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 158190001751 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 158190001752 NADP binding site [chemical binding]; other site 158190001753 homodimer interface [polypeptide binding]; other site 158190001754 active site 158190001755 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 158190001756 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 158190001757 DctM-like transporters; Region: DctM; pfam06808 158190001758 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190001759 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158190001760 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190001761 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158190001762 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 158190001763 Transcriptional regulator [Transcription]; Region: IclR; COG1414 158190001764 Bacterial transcriptional regulator; Region: IclR; pfam01614 158190001765 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 158190001766 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 158190001767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 158190001768 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 158190001769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158190001770 DNA binding residues [nucleotide binding] 158190001771 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 158190001772 oligomerisation interface [polypeptide binding]; other site 158190001773 mobile loop; other site 158190001774 roof hairpin; other site 158190001775 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 158190001776 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 158190001777 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 158190001778 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 158190001779 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 158190001780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190001781 active site 158190001782 phosphorylation site [posttranslational modification] 158190001783 intermolecular recognition site; other site 158190001784 dimerization interface [polypeptide binding]; other site 158190001785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190001786 Walker A motif; other site 158190001787 ATP binding site [chemical binding]; other site 158190001788 Walker B motif; other site 158190001789 arginine finger; other site 158190001790 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 158190001791 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 158190001792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190001793 dimer interface [polypeptide binding]; other site 158190001794 phosphorylation site [posttranslational modification] 158190001795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190001796 ATP binding site [chemical binding]; other site 158190001797 Mg2+ binding site [ion binding]; other site 158190001798 G-X-G motif; other site 158190001799 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 158190001800 DNA polymerase III subunit delta'; Validated; Region: PRK08485 158190001801 Colicin V production protein; Region: Colicin_V; pfam02674 158190001802 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 158190001803 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 158190001804 active site 158190001805 homodimer interface [polypeptide binding]; other site 158190001806 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 158190001807 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 158190001808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 158190001809 nucleotide binding region [chemical binding]; other site 158190001810 ATP-binding site [chemical binding]; other site 158190001811 SEC-C motif; Region: SEC-C; pfam02810 158190001812 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190001813 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190001814 DNA binding site [nucleotide binding] 158190001815 domain linker motif; other site 158190001816 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190001817 dimerization interface [polypeptide binding]; other site 158190001818 ligand binding site [chemical binding]; other site 158190001819 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 158190001820 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 158190001821 NAD(P) binding site [chemical binding]; other site 158190001822 LDH/MDH dimer interface [polypeptide binding]; other site 158190001823 substrate binding site [chemical binding]; other site 158190001824 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190001825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001826 dimer interface [polypeptide binding]; other site 158190001827 conserved gate region; other site 158190001828 putative PBP binding loops; other site 158190001829 ABC-ATPase subunit interface; other site 158190001830 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190001831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001832 dimer interface [polypeptide binding]; other site 158190001833 conserved gate region; other site 158190001834 ABC-ATPase subunit interface; other site 158190001835 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190001836 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190001837 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 158190001838 active site 158190001839 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190001840 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190001841 DNA binding site [nucleotide binding] 158190001842 domain linker motif; other site 158190001843 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190001844 ligand binding site [chemical binding]; other site 158190001845 dimerization interface [polypeptide binding]; other site 158190001846 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190001847 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190001848 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190001849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001850 ABC-ATPase subunit interface; other site 158190001851 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190001852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190001853 dimer interface [polypeptide binding]; other site 158190001854 conserved gate region; other site 158190001855 putative PBP binding loops; other site 158190001856 ABC-ATPase subunit interface; other site 158190001857 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 158190001858 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 158190001859 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 158190001860 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 158190001861 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190001862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190001863 non-specific DNA binding site [nucleotide binding]; other site 158190001864 salt bridge; other site 158190001865 sequence-specific DNA binding site [nucleotide binding]; other site 158190001866 Domain of unknown function (DUF955); Region: DUF955; cl01076 158190001867 alpha-glucosidase; Provisional; Region: PRK10426 158190001868 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 158190001869 putative active site [active] 158190001870 putative catalytic site [active] 158190001871 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 158190001872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190001873 putative substrate translocation pore; other site 158190001874 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 158190001875 Peptidase family M23; Region: Peptidase_M23; pfam01551 158190001876 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 158190001877 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 158190001878 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 158190001879 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 158190001880 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158190001881 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 158190001882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190001883 Walker A motif; other site 158190001884 ATP binding site [chemical binding]; other site 158190001885 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 158190001886 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 158190001887 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 158190001888 active site 158190001889 HslU subunit interaction site [polypeptide binding]; other site 158190001890 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 158190001891 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158190001892 active site 158190001893 DNA binding site [nucleotide binding] 158190001894 Int/Topo IB signature motif; other site 158190001895 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 158190001896 DNA protecting protein DprA; Region: dprA; TIGR00732 158190001897 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 158190001898 hypothetical protein; Provisional; Region: PRK10621 158190001899 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158190001900 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 158190001901 active site 158190001902 DNA binding site [nucleotide binding] 158190001903 Int/Topo IB signature motif; other site 158190001904 cell division protein FtsZ; Validated; Region: PRK09330 158190001905 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 158190001906 nucleotide binding site [chemical binding]; other site 158190001907 SulA interaction site; other site 158190001908 cell division protein FtsA; Region: ftsA; TIGR01174 158190001909 Cell division protein FtsA; Region: FtsA; smart00842 158190001910 Cell division protein FtsA; Region: FtsA; pfam14450 158190001911 cell division protein FtsW; Region: ftsW; TIGR02614 158190001912 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 158190001913 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 158190001914 Mg++ binding site [ion binding]; other site 158190001915 putative catalytic motif [active] 158190001916 putative substrate binding site [chemical binding]; other site 158190001917 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 158190001918 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 158190001919 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158190001920 MraW methylase family; Region: Methyltransf_5; cl17771 158190001921 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 158190001922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 158190001923 MraZ protein; Region: MraZ; pfam02381 158190001924 MraZ protein; Region: MraZ; pfam02381 158190001925 Uncharacterized conserved protein [Function unknown]; Region: COG1543 158190001926 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 158190001927 active site 158190001928 substrate binding site [chemical binding]; other site 158190001929 catalytic site [active] 158190001930 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 158190001931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 158190001932 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158190001933 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 158190001934 active site 158190001935 catalytic site [active] 158190001936 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 158190001937 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 158190001938 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 158190001939 Walker A/P-loop; other site 158190001940 ATP binding site [chemical binding]; other site 158190001941 Q-loop/lid; other site 158190001942 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 158190001943 ABC transporter signature motif; other site 158190001944 Walker B; other site 158190001945 D-loop; other site 158190001946 H-loop/switch region; other site 158190001947 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 158190001948 ATP-NAD kinase; Region: NAD_kinase; pfam01513 158190001949 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 158190001950 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158190001951 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190001952 catalytic residue [active] 158190001953 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190001954 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 158190001955 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 158190001956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190001957 S-adenosylmethionine binding site [chemical binding]; other site 158190001958 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 158190001959 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 158190001960 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 158190001961 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 158190001962 NAD(P) binding site [chemical binding]; other site 158190001963 catalytic residues [active] 158190001964 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 158190001965 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158190001966 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158190001967 substrate binding site [chemical binding]; other site 158190001968 trimer interface [polypeptide binding]; other site 158190001969 Mn binding site [ion binding]; other site 158190001970 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 158190001971 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 158190001972 intersubunit interface [polypeptide binding]; other site 158190001973 active site 158190001974 Zn2+ binding site [ion binding]; other site 158190001975 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 158190001976 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 158190001977 Cl- selectivity filter; other site 158190001978 Cl- binding residues [ion binding]; other site 158190001979 pore gating glutamate residue; other site 158190001980 dimer interface [polypeptide binding]; other site 158190001981 FOG: CBS domain [General function prediction only]; Region: COG0517 158190001982 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 158190001983 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 158190001984 Cl- selectivity filter; other site 158190001985 Cl- binding residues [ion binding]; other site 158190001986 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 158190001987 pore gating glutamate residue; other site 158190001988 dimer interface [polypeptide binding]; other site 158190001989 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158190001990 metal-binding site [ion binding] 158190001991 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158190001992 metal-binding site [ion binding] 158190001993 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 158190001994 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158190001995 Soluble P-type ATPase [General function prediction only]; Region: COG4087 158190001996 elongation factor G; Reviewed; Region: PRK00007 158190001997 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 158190001998 G1 box; other site 158190001999 putative GEF interaction site [polypeptide binding]; other site 158190002000 GTP/Mg2+ binding site [chemical binding]; other site 158190002001 Switch I region; other site 158190002002 G2 box; other site 158190002003 G3 box; other site 158190002004 Switch II region; other site 158190002005 G4 box; other site 158190002006 G5 box; other site 158190002007 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 158190002008 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 158190002009 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 158190002010 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190002011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190002012 non-specific DNA binding site [nucleotide binding]; other site 158190002013 salt bridge; other site 158190002014 sequence-specific DNA binding site [nucleotide binding]; other site 158190002015 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 158190002016 elongation factor G; Reviewed; Region: PRK12740 158190002017 G1 box; other site 158190002018 putative GEF interaction site [polypeptide binding]; other site 158190002019 GTP/Mg2+ binding site [chemical binding]; other site 158190002020 Switch I region; other site 158190002021 G2 box; other site 158190002022 G3 box; other site 158190002023 Switch II region; other site 158190002024 G4 box; other site 158190002025 G5 box; other site 158190002026 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 158190002027 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 158190002028 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 158190002029 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 158190002030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 158190002031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 158190002032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190002033 ATP binding site [chemical binding]; other site 158190002034 putative Mg++ binding site [ion binding]; other site 158190002035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190002036 nucleotide binding region [chemical binding]; other site 158190002037 ATP-binding site [chemical binding]; other site 158190002038 TRCF domain; Region: TRCF; pfam03461 158190002039 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 158190002040 active site 158190002041 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 158190002042 NTPase; Region: NTPase_1; cl17478 158190002043 Family description; Region: ACT_7; pfam13840 158190002044 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 158190002045 ATP cone domain; Region: ATP-cone; pfam03477 158190002046 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 158190002047 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190002048 Zn2+ binding site [ion binding]; other site 158190002049 Mg2+ binding site [ion binding]; other site 158190002050 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 158190002051 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 158190002052 active site 158190002053 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 158190002054 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 158190002055 Tetramer interface [polypeptide binding]; other site 158190002056 active site 158190002057 FMN-binding site [chemical binding]; other site 158190002058 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 158190002059 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158190002060 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190002061 ATP binding site [chemical binding]; other site 158190002062 putative Mg++ binding site [ion binding]; other site 158190002063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190002064 nucleotide binding region [chemical binding]; other site 158190002065 ATP-binding site [chemical binding]; other site 158190002066 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 158190002067 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 158190002068 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 158190002069 active site 158190002070 catalytic residue [active] 158190002071 dimer interface [polypeptide binding]; other site 158190002072 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 158190002073 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 158190002074 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 158190002075 shikimate binding site; other site 158190002076 NAD(P) binding site [chemical binding]; other site 158190002077 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158190002078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158190002079 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158190002080 ABC transporter; Region: ABC_tran_2; pfam12848 158190002081 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158190002082 Maf-like protein; Region: Maf; pfam02545 158190002083 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 158190002084 active site 158190002085 dimer interface [polypeptide binding]; other site 158190002086 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 158190002087 rRNA interaction site [nucleotide binding]; other site 158190002088 S8 interaction site; other site 158190002089 putative laminin-1 binding site; other site 158190002090 elongation factor Ts; Provisional; Region: tsf; PRK09377 158190002091 UBA/TS-N domain; Region: UBA; pfam00627 158190002092 Elongation factor TS; Region: EF_TS; pfam00889 158190002093 Elongation factor TS; Region: EF_TS; pfam00889 158190002094 ribosome recycling factor; Reviewed; Region: frr; PRK00083 158190002095 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 158190002096 hinge region; other site 158190002097 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 158190002098 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 158190002099 catalytic residue [active] 158190002100 putative FPP diphosphate binding site; other site 158190002101 putative FPP binding hydrophobic cleft; other site 158190002102 dimer interface [polypeptide binding]; other site 158190002103 putative IPP diphosphate binding site; other site 158190002104 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 158190002105 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 158190002106 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 158190002107 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 158190002108 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 158190002109 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 158190002110 RIP metalloprotease RseP; Region: TIGR00054 158190002111 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 158190002112 active site 158190002113 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 158190002114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 158190002115 protein binding site [polypeptide binding]; other site 158190002116 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 158190002117 putative substrate binding region [chemical binding]; other site 158190002118 replicative DNA helicase; Region: DnaB; TIGR00665 158190002119 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 158190002120 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 158190002121 Walker A motif; other site 158190002122 ATP binding site [chemical binding]; other site 158190002123 Walker B motif; other site 158190002124 DNA binding loops [nucleotide binding] 158190002125 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 158190002126 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 158190002127 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 158190002128 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 158190002129 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158190002130 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158190002131 dimer interface [polypeptide binding]; other site 158190002132 ssDNA binding site [nucleotide binding]; other site 158190002133 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158190002134 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 158190002135 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 158190002136 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158190002137 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 158190002138 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 158190002139 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 158190002140 active site 158190002141 HIGH motif; other site 158190002142 KMSKS motif; other site 158190002143 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 158190002144 tRNA binding surface [nucleotide binding]; other site 158190002145 anticodon binding site; other site 158190002146 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 158190002147 putative tRNA-binding site [nucleotide binding]; other site 158190002148 HflK protein; Region: hflK; TIGR01933 158190002149 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 158190002150 HflC protein; Region: hflC; TIGR01932 158190002151 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 158190002152 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 158190002153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190002154 motif II; other site 158190002155 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 158190002156 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158190002157 Walker A/P-loop; other site 158190002158 ATP binding site [chemical binding]; other site 158190002159 Q-loop/lid; other site 158190002160 ABC transporter signature motif; other site 158190002161 Walker B; other site 158190002162 D-loop; other site 158190002163 H-loop/switch region; other site 158190002164 argininosuccinate synthase; Provisional; Region: PRK13820 158190002165 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 158190002166 ANP binding site [chemical binding]; other site 158190002167 Substrate Binding Site II [chemical binding]; other site 158190002168 Substrate Binding Site I [chemical binding]; other site 158190002169 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 158190002170 nucleoside/Zn binding site; other site 158190002171 dimer interface [polypeptide binding]; other site 158190002172 catalytic motif [active] 158190002173 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 158190002174 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 158190002175 active site 158190002176 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190002177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002178 dimer interface [polypeptide binding]; other site 158190002179 conserved gate region; other site 158190002180 putative PBP binding loops; other site 158190002181 ABC-ATPase subunit interface; other site 158190002182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002183 dimer interface [polypeptide binding]; other site 158190002184 conserved gate region; other site 158190002185 putative PBP binding loops; other site 158190002186 ABC-ATPase subunit interface; other site 158190002187 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158190002188 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190002189 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158190002190 MarR family; Region: MarR_2; pfam12802 158190002191 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190002192 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190002193 nucleotide binding site [chemical binding]; other site 158190002194 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190002195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190002196 dimerization interface [polypeptide binding]; other site 158190002197 putative DNA binding site [nucleotide binding]; other site 158190002198 putative Zn2+ binding site [ion binding]; other site 158190002199 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 158190002200 dimer interface [polypeptide binding]; other site 158190002201 Citrate synthase; Region: Citrate_synt; pfam00285 158190002202 active site 158190002203 citrylCoA binding site [chemical binding]; other site 158190002204 NADH binding [chemical binding]; other site 158190002205 cationic pore residues; other site 158190002206 oxalacetate/citrate binding site [chemical binding]; other site 158190002207 coenzyme A binding site [chemical binding]; other site 158190002208 catalytic triad [active] 158190002209 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 158190002210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190002211 motif II; other site 158190002212 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 158190002213 isocitrate dehydrogenase; Validated; Region: PRK06451 158190002214 aconitate hydratase; Validated; Region: PRK07229 158190002215 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 158190002216 substrate binding site [chemical binding]; other site 158190002217 ligand binding site [chemical binding]; other site 158190002218 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 158190002219 substrate binding site [chemical binding]; other site 158190002220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190002221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190002222 putative substrate translocation pore; other site 158190002223 Divergent PAP2 family; Region: DUF212; pfam02681 158190002224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190002225 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158190002226 substrate binding pocket [chemical binding]; other site 158190002227 membrane-bound complex binding site; other site 158190002228 hinge residues; other site 158190002229 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158190002230 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190002231 substrate binding pocket [chemical binding]; other site 158190002232 membrane-bound complex binding site; other site 158190002233 hinge residues; other site 158190002234 SNF2 Helicase protein; Region: DUF3670; pfam12419 158190002235 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 158190002236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190002237 ATP binding site [chemical binding]; other site 158190002238 putative Mg++ binding site [ion binding]; other site 158190002239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190002240 nucleotide binding region [chemical binding]; other site 158190002241 ATP-binding site [chemical binding]; other site 158190002242 Uncharacterized conserved protein [Function unknown]; Region: COG4279 158190002243 SWIM zinc finger; Region: SWIM; pfam04434 158190002244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002245 dimer interface [polypeptide binding]; other site 158190002246 conserved gate region; other site 158190002247 putative PBP binding loops; other site 158190002248 ABC-ATPase subunit interface; other site 158190002249 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158190002250 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158190002251 Walker A/P-loop; other site 158190002252 ATP binding site [chemical binding]; other site 158190002253 Q-loop/lid; other site 158190002254 ABC transporter signature motif; other site 158190002255 Walker B; other site 158190002256 D-loop; other site 158190002257 H-loop/switch region; other site 158190002258 Haemolysin-III related; Region: HlyIII; cl03831 158190002259 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 158190002260 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 158190002261 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158190002262 catalytic residues [active] 158190002263 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 158190002264 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 158190002265 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 158190002266 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 158190002267 Uncharacterized conserved protein [Function unknown]; Region: COG2006 158190002268 Domain of unknown function (DUF362); Region: DUF362; pfam04015 158190002269 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 158190002270 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 158190002271 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 158190002272 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 158190002273 Part of AAA domain; Region: AAA_19; pfam13245 158190002274 Family description; Region: UvrD_C_2; pfam13538 158190002275 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 158190002276 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 158190002277 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 158190002278 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 158190002279 active site 158190002280 catalytic site [active] 158190002281 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 158190002282 AAA domain; Region: AAA_31; pfam13614 158190002283 P-loop; other site 158190002284 Magnesium ion binding site [ion binding]; other site 158190002285 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 158190002286 Magnesium ion binding site [ion binding]; other site 158190002287 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 158190002288 beta-galactosidase; Region: BGL; TIGR03356 158190002289 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 158190002290 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 158190002291 asparagine synthetase AsnA; Provisional; Region: PRK05425 158190002292 motif 1; other site 158190002293 dimer interface [polypeptide binding]; other site 158190002294 active site 158190002295 motif 2; other site 158190002296 motif 3; other site 158190002297 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 158190002298 active site 158190002299 putative catalytic site [active] 158190002300 DNA binding site [nucleotide binding] 158190002301 putative phosphate binding site [ion binding]; other site 158190002302 metal binding site A [ion binding]; metal-binding site 158190002303 AP binding site [nucleotide binding]; other site 158190002304 metal binding site B [ion binding]; metal-binding site 158190002305 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 158190002306 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 158190002307 G1 box; other site 158190002308 putative GEF interaction site [polypeptide binding]; other site 158190002309 GTP/Mg2+ binding site [chemical binding]; other site 158190002310 Switch I region; other site 158190002311 G2 box; other site 158190002312 G3 box; other site 158190002313 Switch II region; other site 158190002314 G4 box; other site 158190002315 G5 box; other site 158190002316 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 158190002317 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 158190002318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190002319 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 158190002320 putative substrate translocation pore; other site 158190002321 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 158190002322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190002323 Coenzyme A binding pocket [chemical binding]; other site 158190002324 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 158190002325 Low molecular weight phosphatase family; Region: LMWPc; cd00115 158190002326 active site 158190002327 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 158190002328 Predicted permeases [General function prediction only]; Region: COG0701 158190002329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190002330 putative DNA binding site [nucleotide binding]; other site 158190002331 dimerization interface [polypeptide binding]; other site 158190002332 putative Zn2+ binding site [ion binding]; other site 158190002333 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158190002334 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158190002335 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158190002336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002337 dimer interface [polypeptide binding]; other site 158190002338 conserved gate region; other site 158190002339 putative PBP binding loops; other site 158190002340 ABC-ATPase subunit interface; other site 158190002341 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 158190002342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002343 dimer interface [polypeptide binding]; other site 158190002344 conserved gate region; other site 158190002345 putative PBP binding loops; other site 158190002346 ABC-ATPase subunit interface; other site 158190002347 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 158190002348 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190002349 substrate binding pocket [chemical binding]; other site 158190002350 membrane-bound complex binding site; other site 158190002351 hinge residues; other site 158190002352 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158190002353 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158190002354 Walker A/P-loop; other site 158190002355 ATP binding site [chemical binding]; other site 158190002356 Q-loop/lid; other site 158190002357 ABC transporter signature motif; other site 158190002358 Walker B; other site 158190002359 D-loop; other site 158190002360 H-loop/switch region; other site 158190002361 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190002362 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190002363 TM-ABC transporter signature motif; other site 158190002364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190002365 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190002366 TM-ABC transporter signature motif; other site 158190002367 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190002368 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190002369 Walker A/P-loop; other site 158190002370 ATP binding site [chemical binding]; other site 158190002371 Q-loop/lid; other site 158190002372 ABC transporter signature motif; other site 158190002373 Walker B; other site 158190002374 D-loop; other site 158190002375 H-loop/switch region; other site 158190002376 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190002377 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190002378 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 158190002379 ligand binding site [chemical binding]; other site 158190002380 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 158190002381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158190002382 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 158190002383 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158190002384 Beta-Casp domain; Region: Beta-Casp; smart01027 158190002385 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 158190002386 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 158190002387 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 158190002388 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 158190002389 dimer interface [polypeptide binding]; other site 158190002390 active site 158190002391 metal binding site [ion binding]; metal-binding site 158190002392 Predicted membrane protein [Function unknown]; Region: COG3462 158190002393 Short C-terminal domain; Region: SHOCT; pfam09851 158190002394 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158190002395 active site 158190002396 phosphorylation site [posttranslational modification] 158190002397 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 158190002398 Ligand Binding Site [chemical binding]; other site 158190002399 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 158190002400 V-type ATP synthase subunit B; Provisional; Region: PRK04196 158190002401 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158190002402 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 158190002403 Walker A motif homologous position; other site 158190002404 Walker B motif; other site 158190002405 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 158190002406 V-type ATP synthase subunit A; Provisional; Region: PRK04192 158190002407 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 158190002408 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 158190002409 Walker A motif/ATP binding site; other site 158190002410 Walker B motif; other site 158190002411 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 158190002412 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 158190002413 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 158190002414 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 158190002415 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 158190002416 V-type ATP synthase subunit I; Validated; Region: PRK05771 158190002417 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 158190002418 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 158190002419 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 158190002420 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 158190002421 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 158190002422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190002423 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158190002424 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190002425 active site 158190002426 metal binding site [ion binding]; metal-binding site 158190002427 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 158190002428 putative acyl-acceptor binding pocket; other site 158190002429 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 158190002430 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 158190002431 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190002432 active site 158190002433 metal binding site [ion binding]; metal-binding site 158190002434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190002435 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 158190002436 putative ADP-binding pocket [chemical binding]; other site 158190002437 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190002438 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190002439 metal binding site [ion binding]; metal-binding site 158190002440 active site 158190002441 I-site; other site 158190002442 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 158190002443 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 158190002444 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 158190002445 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 158190002446 AzlC protein; Region: AzlC; pfam03591 158190002447 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 158190002448 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190002449 active site 158190002450 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 158190002451 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 158190002452 putative ATP binding site [chemical binding]; other site 158190002453 putative substrate interface [chemical binding]; other site 158190002454 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 158190002455 putative ligand binding site [chemical binding]; other site 158190002456 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 158190002457 active site 158190002458 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 158190002459 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 158190002460 active site 158190002461 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158190002462 substrate binding site [chemical binding]; other site 158190002463 catalytic residues [active] 158190002464 dimer interface [polypeptide binding]; other site 158190002465 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 158190002466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158190002467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190002468 homodimer interface [polypeptide binding]; other site 158190002469 catalytic residue [active] 158190002470 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 158190002471 dihydrodipicolinate synthase; Region: dapA; TIGR00674 158190002472 dimer interface [polypeptide binding]; other site 158190002473 active site 158190002474 catalytic residue [active] 158190002475 dihydrodipicolinate reductase; Provisional; Region: PRK00048 158190002476 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 158190002477 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 158190002478 DNA topoisomerase III; Provisional; Region: PRK07726 158190002479 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 158190002480 active site 158190002481 putative interdomain interaction site [polypeptide binding]; other site 158190002482 putative metal-binding site [ion binding]; other site 158190002483 putative nucleotide binding site [chemical binding]; other site 158190002484 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 158190002485 domain I; other site 158190002486 DNA binding groove [nucleotide binding] 158190002487 phosphate binding site [ion binding]; other site 158190002488 domain II; other site 158190002489 domain III; other site 158190002490 nucleotide binding site [chemical binding]; other site 158190002491 catalytic site [active] 158190002492 domain IV; other site 158190002493 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 158190002494 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 158190002495 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 158190002496 active site 158190002497 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 158190002498 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190002499 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 158190002500 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 158190002501 generic binding surface I; other site 158190002502 generic binding surface II; other site 158190002503 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 158190002504 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 158190002505 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 158190002506 putative active site [active] 158190002507 putative substrate binding site [chemical binding]; other site 158190002508 putative cosubstrate binding site; other site 158190002509 catalytic site [active] 158190002510 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 158190002511 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 158190002512 Nitrogen regulatory protein P-II; Region: P-II; smart00938 158190002513 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 158190002514 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 158190002515 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158190002516 active site 158190002517 FOG: CBS domain [General function prediction only]; Region: COG0517 158190002518 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 158190002519 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 158190002520 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 158190002521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 158190002522 ATP binding site [chemical binding]; other site 158190002523 G-X-G motif; other site 158190002524 DRTGG domain; Region: DRTGG; pfam07085 158190002525 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 158190002526 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 158190002527 active site 158190002528 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 158190002529 PHP-associated; Region: PHP_C; pfam13263 158190002530 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 158190002531 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 158190002532 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190002533 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 158190002534 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 158190002535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190002536 Walker A motif; other site 158190002537 ATP binding site [chemical binding]; other site 158190002538 Walker B motif; other site 158190002539 arginine finger; other site 158190002540 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 158190002541 trigger factor; Provisional; Region: tig; PRK01490 158190002542 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 158190002543 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 158190002544 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 158190002545 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 158190002546 oligomer interface [polypeptide binding]; other site 158190002547 active site residues [active] 158190002548 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 158190002549 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 158190002550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190002551 Walker A motif; other site 158190002552 ATP binding site [chemical binding]; other site 158190002553 Walker B motif; other site 158190002554 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 158190002555 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 158190002556 DHH family; Region: DHH; pfam01368 158190002557 DHHA1 domain; Region: DHHA1; pfam02272 158190002558 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 158190002559 active site 158190002560 dimerization interface [polypeptide binding]; other site 158190002561 oligoendopeptidase F; Region: pepF; TIGR00181 158190002562 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 158190002563 active site 158190002564 Zn binding site [ion binding]; other site 158190002565 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 158190002566 active site 158190002567 catalytic triad [active] 158190002568 oxyanion hole [active] 158190002569 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190002570 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190002571 metal binding site [ion binding]; metal-binding site 158190002572 active site 158190002573 I-site; other site 158190002574 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 158190002575 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 158190002576 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 158190002577 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 158190002578 HlyD family secretion protein; Region: HlyD_3; pfam13437 158190002579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190002580 active site 158190002581 I-site; other site 158190002582 metal binding site [ion binding]; metal-binding site 158190002583 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158190002584 Cation efflux family; Region: Cation_efflux; cl00316 158190002585 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 158190002586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002587 dimer interface [polypeptide binding]; other site 158190002588 conserved gate region; other site 158190002589 putative PBP binding loops; other site 158190002590 ABC-ATPase subunit interface; other site 158190002591 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 158190002592 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 158190002593 Walker A/P-loop; other site 158190002594 ATP binding site [chemical binding]; other site 158190002595 Q-loop/lid; other site 158190002596 ABC transporter signature motif; other site 158190002597 Walker B; other site 158190002598 D-loop; other site 158190002599 H-loop/switch region; other site 158190002600 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 158190002601 NMT1-like family; Region: NMT1_2; pfam13379 158190002602 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 158190002603 Flavoprotein; Region: Flavoprotein; pfam02441 158190002604 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 158190002605 UbiA prenyltransferase family; Region: UbiA; pfam01040 158190002606 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 158190002607 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 158190002608 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 158190002609 TQO small subunit DoxD; Region: DoxD; pfam04173 158190002610 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 158190002611 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 158190002612 substrate binding pocket [chemical binding]; other site 158190002613 chain length determination region; other site 158190002614 substrate-Mg2+ binding site; other site 158190002615 catalytic residues [active] 158190002616 aspartate-rich region 1; other site 158190002617 active site lid residues [active] 158190002618 aspartate-rich region 2; other site 158190002619 Uncharacterized conserved protein [Function unknown]; Region: COG2461 158190002620 Family of unknown function (DUF438); Region: DUF438; pfam04282 158190002621 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 158190002622 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 158190002623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158190002624 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158190002625 FOG: CBS domain [General function prediction only]; Region: COG0517 158190002626 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 158190002627 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 158190002628 Sodium Bile acid symporter family; Region: SBF; cl17470 158190002629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190002630 dimerization interface [polypeptide binding]; other site 158190002631 putative DNA binding site [nucleotide binding]; other site 158190002632 putative Zn2+ binding site [ion binding]; other site 158190002633 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 158190002634 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 158190002635 dimer interface [polypeptide binding]; other site 158190002636 active site 158190002637 metal binding site [ion binding]; metal-binding site 158190002638 Predicted permease; Region: DUF318; cl17795 158190002639 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158190002640 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158190002641 ligand binding site [chemical binding]; other site 158190002642 flexible hinge region; other site 158190002643 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 158190002644 putative switch regulator; other site 158190002645 non-specific DNA interactions [nucleotide binding]; other site 158190002646 DNA binding site [nucleotide binding] 158190002647 sequence specific DNA binding site [nucleotide binding]; other site 158190002648 putative cAMP binding site [chemical binding]; other site 158190002649 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 158190002650 Pyruvate formate lyase 1; Region: PFL1; cd01678 158190002651 coenzyme A binding site [chemical binding]; other site 158190002652 active site 158190002653 catalytic residues [active] 158190002654 glycine loop; other site 158190002655 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 158190002656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190002657 FeS/SAM binding site; other site 158190002658 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 158190002659 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 158190002660 catalytic residues [active] 158190002661 dimer interface [polypeptide binding]; other site 158190002662 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 158190002663 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190002664 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190002665 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 158190002666 PAS domain; Region: PAS_9; pfam13426 158190002667 PAS fold; Region: PAS_4; pfam08448 158190002668 GAF domain; Region: GAF_2; pfam13185 158190002669 GAF domain; Region: GAF; cl17456 158190002670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158190002671 PAS domain; Region: PAS_9; pfam13426 158190002672 putative active site [active] 158190002673 heme pocket [chemical binding]; other site 158190002674 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190002675 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190002676 metal binding site [ion binding]; metal-binding site 158190002677 active site 158190002678 I-site; other site 158190002679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190002680 Zn2+ binding site [ion binding]; other site 158190002681 Mg2+ binding site [ion binding]; other site 158190002682 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 158190002683 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 158190002684 putative ligand binding site [chemical binding]; other site 158190002685 putative NAD binding site [chemical binding]; other site 158190002686 catalytic site [active] 158190002687 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158190002688 active site residue [active] 158190002689 LPP20 lipoprotein; Region: LPP20; cl15824 158190002690 LPP20 lipoprotein; Region: LPP20; pfam02169 158190002691 Cell-cycle control medial ring component; Region: Blt1; pfam12754 158190002692 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 158190002693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 158190002694 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 158190002695 PLD-like domain; Region: PLDc_2; pfam13091 158190002696 putative homodimer interface [polypeptide binding]; other site 158190002697 putative active site [active] 158190002698 catalytic site [active] 158190002699 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 158190002700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190002701 ATP binding site [chemical binding]; other site 158190002702 putative Mg++ binding site [ion binding]; other site 158190002703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190002704 nucleotide binding region [chemical binding]; other site 158190002705 ATP-binding site [chemical binding]; other site 158190002706 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 158190002707 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 158190002708 active site 158190002709 8-oxo-dGMP binding site [chemical binding]; other site 158190002710 nudix motif; other site 158190002711 metal binding site [ion binding]; metal-binding site 158190002712 Competence protein CoiA-like family; Region: CoiA; cl11541 158190002713 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 158190002714 active site 158190002715 Methyltransferase domain; Region: Methyltransf_23; pfam13489 158190002716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190002717 S-adenosylmethionine binding site [chemical binding]; other site 158190002718 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 158190002719 trimer interface [polypeptide binding]; other site 158190002720 active site 158190002721 G bulge; other site 158190002722 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 158190002723 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 158190002724 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 158190002725 Uncharacterized conserved protein [Function unknown]; Region: COG3535 158190002726 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 158190002727 Na binding site [ion binding]; other site 158190002728 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 158190002729 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 158190002730 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 158190002731 NAD-dependent deacetylase; Provisional; Region: PRK14138 158190002732 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 158190002733 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158190002734 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158190002735 Walker A/P-loop; other site 158190002736 ATP binding site [chemical binding]; other site 158190002737 Q-loop/lid; other site 158190002738 ABC transporter signature motif; other site 158190002739 Walker B; other site 158190002740 D-loop; other site 158190002741 H-loop/switch region; other site 158190002742 FtsX-like permease family; Region: FtsX; pfam02687 158190002743 FtsX-like permease family; Region: FtsX; pfam02687 158190002744 H+ Antiporter protein; Region: 2A0121; TIGR00900 158190002745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190002746 putative substrate translocation pore; other site 158190002747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190002748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190002749 Competence protein CoiA-like family; Region: CoiA; cl11541 158190002750 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 158190002751 Mrr N-terminal domain; Region: Mrr_N; pfam14338 158190002752 Restriction endonuclease; Region: Mrr_cat; pfam04471 158190002753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190002754 non-specific DNA binding site [nucleotide binding]; other site 158190002755 salt bridge; other site 158190002756 sequence-specific DNA binding site [nucleotide binding]; other site 158190002757 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 158190002758 metal ion-dependent adhesion site (MIDAS); other site 158190002759 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 158190002760 putative ADP-ribose binding site [chemical binding]; other site 158190002761 putative active site [active] 158190002762 AAA domain; Region: AAA_23; pfam13476 158190002763 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190002764 active site 158190002765 metal binding site [ion binding]; metal-binding site 158190002766 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 158190002767 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 158190002768 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 158190002769 active site 158190002770 putative substrate binding pocket [chemical binding]; other site 158190002771 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 158190002772 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 158190002773 active site 158190002774 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 158190002775 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 158190002776 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190002777 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190002778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190002779 Walker A/P-loop; other site 158190002780 ATP binding site [chemical binding]; other site 158190002781 Q-loop/lid; other site 158190002782 ABC transporter signature motif; other site 158190002783 Walker B; other site 158190002784 D-loop; other site 158190002785 H-loop/switch region; other site 158190002786 TOBE domain; Region: TOBE_2; pfam08402 158190002787 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190002788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002789 conserved gate region; other site 158190002790 dimer interface [polypeptide binding]; other site 158190002791 putative PBP binding loops; other site 158190002792 ABC-ATPase subunit interface; other site 158190002793 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158190002794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002795 dimer interface [polypeptide binding]; other site 158190002796 conserved gate region; other site 158190002797 putative PBP binding loops; other site 158190002798 ABC-ATPase subunit interface; other site 158190002799 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 158190002800 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 158190002801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190002802 catalytic residue [active] 158190002803 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 158190002804 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 158190002805 substrate binding site [chemical binding]; other site 158190002806 active site 158190002807 catalytic residues [active] 158190002808 heterodimer interface [polypeptide binding]; other site 158190002809 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 158190002810 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 158190002811 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 158190002812 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 158190002813 Glutamine amidotransferase class-I; Region: GATase; pfam00117 158190002814 glutamine binding [chemical binding]; other site 158190002815 catalytic triad [active] 158190002816 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 158190002817 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 158190002818 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 158190002819 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 158190002820 active site 158190002821 ribulose/triose binding site [chemical binding]; other site 158190002822 phosphate binding site [ion binding]; other site 158190002823 substrate (anthranilate) binding pocket [chemical binding]; other site 158190002824 product (indole) binding pocket [chemical binding]; other site 158190002825 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 158190002826 active site 158190002827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158190002828 PAS domain; Region: PAS_9; pfam13426 158190002829 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158190002830 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 158190002831 LabA_like proteins; Region: LabA_like; cd06167 158190002832 putative metal binding site [ion binding]; other site 158190002833 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 158190002834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190002835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190002836 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 158190002837 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 158190002838 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158190002839 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 158190002840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190002841 motif II; other site 158190002842 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 158190002843 RloB-like protein; Region: RloB; pfam13707 158190002844 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 158190002845 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 158190002846 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158190002847 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158190002848 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190002849 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 158190002850 Ligand binding site; other site 158190002851 metal-binding site 158190002852 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 158190002853 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158190002854 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190002855 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 158190002856 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158190002857 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 158190002858 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 158190002859 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 158190002860 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158190002861 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 158190002862 active site 158190002863 trimer interface [polypeptide binding]; other site 158190002864 allosteric site; other site 158190002865 active site lid [active] 158190002866 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158190002867 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 158190002868 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 158190002869 active site 158190002870 dimer interface [polypeptide binding]; other site 158190002871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190002872 DNA binding site [nucleotide binding] 158190002873 domain linker motif; other site 158190002874 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158190002875 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190002876 ligand binding site [chemical binding]; other site 158190002877 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190002878 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158190002879 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158190002880 DctM-like transporters; Region: DctM; pfam06808 158190002881 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190002882 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 158190002883 putative active site [active] 158190002884 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 158190002885 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 158190002886 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 158190002887 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 158190002888 lipoyl-biotinyl attachment site [posttranslational modification]; other site 158190002889 HlyD family secretion protein; Region: HlyD_3; pfam13437 158190002890 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 158190002891 Protein export membrane protein; Region: SecD_SecF; cl14618 158190002892 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 158190002893 EamA-like transporter family; Region: EamA; pfam00892 158190002894 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158190002895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190002896 Walker A/P-loop; other site 158190002897 ATP binding site [chemical binding]; other site 158190002898 Q-loop/lid; other site 158190002899 ABC transporter signature motif; other site 158190002900 Walker B; other site 158190002901 D-loop; other site 158190002902 H-loop/switch region; other site 158190002903 ABC transporter; Region: ABC_tran_2; pfam12848 158190002904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158190002905 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 158190002906 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158190002907 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 158190002908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190002909 Coenzyme A binding pocket [chemical binding]; other site 158190002910 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158190002911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190002912 Coenzyme A binding pocket [chemical binding]; other site 158190002913 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 158190002914 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158190002915 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 158190002916 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158190002917 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 158190002918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190002919 FeS/SAM binding site; other site 158190002920 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 158190002921 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 158190002922 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 158190002923 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 158190002924 homodimer interface [polypeptide binding]; other site 158190002925 substrate-cofactor binding pocket; other site 158190002926 catalytic residue [active] 158190002927 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190002928 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190002929 metal binding site [ion binding]; metal-binding site 158190002930 I-site; other site 158190002931 active site 158190002932 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190002933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190002934 metal binding site [ion binding]; metal-binding site 158190002935 active site 158190002936 I-site; other site 158190002937 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158190002938 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190002939 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158190002940 Metal-binding active site; metal-binding site 158190002941 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 158190002942 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190002943 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190002944 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190002945 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190002946 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190002947 TM-ABC transporter signature motif; other site 158190002948 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190002949 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190002950 Walker A/P-loop; other site 158190002951 ATP binding site [chemical binding]; other site 158190002952 Q-loop/lid; other site 158190002953 ABC transporter signature motif; other site 158190002954 Walker B; other site 158190002955 D-loop; other site 158190002956 H-loop/switch region; other site 158190002957 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190002958 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158190002959 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158190002960 ligand binding site [chemical binding]; other site 158190002961 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190002962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190002963 DNA binding site [nucleotide binding] 158190002964 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190002965 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190002966 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190002967 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190002968 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190002969 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190002970 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 158190002971 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 158190002972 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190002973 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190002974 DNA binding site [nucleotide binding] 158190002975 domain linker motif; other site 158190002976 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190002977 dimerization interface [polypeptide binding]; other site 158190002978 ligand binding site [chemical binding]; other site 158190002979 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 158190002980 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 158190002981 putative active site [active] 158190002982 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190002983 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190002984 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190002985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002986 dimer interface [polypeptide binding]; other site 158190002987 conserved gate region; other site 158190002988 putative PBP binding loops; other site 158190002989 ABC-ATPase subunit interface; other site 158190002990 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190002991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190002992 dimer interface [polypeptide binding]; other site 158190002993 conserved gate region; other site 158190002994 ABC-ATPase subunit interface; other site 158190002995 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 158190002996 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 158190002997 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 158190002998 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 158190002999 active site 158190003000 Beta-lactamase; Region: Beta-lactamase; cl17358 158190003001 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 158190003002 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190003003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190003004 dimer interface [polypeptide binding]; other site 158190003005 ABC-ATPase subunit interface; other site 158190003006 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190003007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190003008 dimer interface [polypeptide binding]; other site 158190003009 conserved gate region; other site 158190003010 ABC-ATPase subunit interface; other site 158190003011 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190003012 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 158190003013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158190003014 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 158190003015 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 158190003016 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 158190003017 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158190003018 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158190003019 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158190003020 putative active site [active] 158190003021 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190003022 nucleotide binding site [chemical binding]; other site 158190003023 Predicted membrane protein [Function unknown]; Region: COG2246 158190003024 GtrA-like protein; Region: GtrA; pfam04138 158190003025 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 158190003026 catalytic residues [active] 158190003027 dimer interface [polypeptide binding]; other site 158190003028 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158190003029 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158190003030 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 158190003031 active site 158190003032 catalytic site [active] 158190003033 metal binding site [ion binding]; metal-binding site 158190003034 dimer interface [polypeptide binding]; other site 158190003035 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190003036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190003037 dimer interface [polypeptide binding]; other site 158190003038 conserved gate region; other site 158190003039 putative PBP binding loops; other site 158190003040 ABC-ATPase subunit interface; other site 158190003041 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 158190003042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190003043 dimer interface [polypeptide binding]; other site 158190003044 conserved gate region; other site 158190003045 putative PBP binding loops; other site 158190003046 ABC-ATPase subunit interface; other site 158190003047 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190003048 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190003049 Protein of unknown function, DUF624; Region: DUF624; cl02369 158190003050 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 158190003051 Na binding site [ion binding]; other site 158190003052 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 158190003053 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 158190003054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190003055 catalytic residue [active] 158190003056 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 158190003057 ApbE family; Region: ApbE; pfam02424 158190003058 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 158190003059 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 158190003060 active site 158190003061 catalytic site [active] 158190003062 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190003063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190003064 dimer interface [polypeptide binding]; other site 158190003065 conserved gate region; other site 158190003066 putative PBP binding loops; other site 158190003067 ABC-ATPase subunit interface; other site 158190003068 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190003069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190003070 putative PBP binding loops; other site 158190003071 dimer interface [polypeptide binding]; other site 158190003072 ABC-ATPase subunit interface; other site 158190003073 PBP superfamily domain; Region: PBP_like_2; cl17296 158190003074 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190003075 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190003076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190003077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190003078 DNA binding site [nucleotide binding] 158190003079 domain linker motif; other site 158190003080 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190003081 ligand binding site [chemical binding]; other site 158190003082 dimerization interface [polypeptide binding]; other site 158190003083 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 158190003084 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 158190003085 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 158190003086 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 158190003087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158190003088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158190003089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190003090 Walker A/P-loop; other site 158190003091 ATP binding site [chemical binding]; other site 158190003092 Q-loop/lid; other site 158190003093 ABC transporter signature motif; other site 158190003094 Walker B; other site 158190003095 D-loop; other site 158190003096 H-loop/switch region; other site 158190003097 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158190003098 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158190003099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190003100 Walker A/P-loop; other site 158190003101 ATP binding site [chemical binding]; other site 158190003102 Q-loop/lid; other site 158190003103 ABC transporter signature motif; other site 158190003104 Walker B; other site 158190003105 D-loop; other site 158190003106 H-loop/switch region; other site 158190003107 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 158190003108 HipA-like N-terminal domain; Region: HipA_N; pfam07805 158190003109 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 158190003110 HipA-like C-terminal domain; Region: HipA_C; pfam07804 158190003111 HipA N-terminal domain; Region: couple_hipA; TIGR03071 158190003112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190003113 non-specific DNA binding site [nucleotide binding]; other site 158190003114 salt bridge; other site 158190003115 sequence-specific DNA binding site [nucleotide binding]; other site 158190003116 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 158190003117 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158190003118 minor groove reading motif; other site 158190003119 helix-hairpin-helix signature motif; other site 158190003120 substrate binding pocket [chemical binding]; other site 158190003121 active site 158190003122 HNH nucleases; Region: HNHc; smart00507 158190003123 active site 158190003124 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 158190003125 putative deacylase active site [active] 158190003126 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 158190003127 dimer interface [polypeptide binding]; other site 158190003128 ADP-ribose binding site [chemical binding]; other site 158190003129 active site 158190003130 nudix motif; other site 158190003131 metal binding site [ion binding]; metal-binding site 158190003132 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158190003133 active site 158190003134 phosphorylation site [posttranslational modification] 158190003135 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 158190003136 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 158190003137 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 158190003138 active site 158190003139 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190003140 Zn2+ binding site [ion binding]; other site 158190003141 Mg2+ binding site [ion binding]; other site 158190003142 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 158190003143 dihydropteroate synthase; Region: DHPS; TIGR01496 158190003144 substrate binding pocket [chemical binding]; other site 158190003145 dimer interface [polypeptide binding]; other site 158190003146 inhibitor binding site; inhibition site 158190003147 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 158190003148 homooctamer interface [polypeptide binding]; other site 158190003149 active site 158190003150 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 158190003151 catalytic center binding site [active] 158190003152 ATP binding site [chemical binding]; other site 158190003153 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 158190003154 ApbE family; Region: ApbE; pfam02424 158190003155 FMN-binding domain; Region: FMN_bind; cl01081 158190003156 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 158190003157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190003158 Walker A/P-loop; other site 158190003159 ATP binding site [chemical binding]; other site 158190003160 Q-loop/lid; other site 158190003161 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 158190003162 ABC transporter signature motif; other site 158190003163 Walker B; other site 158190003164 D-loop; other site 158190003165 H-loop/switch region; other site 158190003166 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 158190003167 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158190003168 active site 158190003169 metal binding site [ion binding]; metal-binding site 158190003170 DNA binding site [nucleotide binding] 158190003171 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 158190003172 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 158190003173 MFS/sugar transport protein; Region: MFS_2; pfam13347 158190003174 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 158190003175 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158190003176 metal-binding site [ion binding] 158190003177 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 158190003178 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158190003179 metal-binding site [ion binding] 158190003180 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158190003181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190003182 motif II; other site 158190003183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190003184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190003185 putative substrate translocation pore; other site 158190003186 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158190003187 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190003188 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190003189 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190003190 TM-ABC transporter signature motif; other site 158190003191 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190003192 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190003193 Walker A/P-loop; other site 158190003194 ATP binding site [chemical binding]; other site 158190003195 Q-loop/lid; other site 158190003196 ABC transporter signature motif; other site 158190003197 Walker B; other site 158190003198 D-loop; other site 158190003199 H-loop/switch region; other site 158190003200 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190003201 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190003202 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 158190003203 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190003204 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190003205 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190003206 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190003207 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190003208 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190003209 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190003210 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190003211 DNA binding site [nucleotide binding] 158190003212 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190003213 domain linker motif; other site 158190003214 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190003215 dimerization interface [polypeptide binding]; other site 158190003216 ligand binding site [chemical binding]; other site 158190003217 Predicted acetyltransferase [General function prediction only]; Region: COG5628 158190003218 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 158190003219 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 158190003220 active site 158190003221 metal binding site [ion binding]; metal-binding site 158190003222 homotetramer interface [polypeptide binding]; other site 158190003223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190003224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190003225 dimer interface [polypeptide binding]; other site 158190003226 phosphorylation site [posttranslational modification] 158190003227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190003228 ATP binding site [chemical binding]; other site 158190003229 Mg2+ binding site [ion binding]; other site 158190003230 G-X-G motif; other site 158190003231 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190003232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190003233 active site 158190003234 phosphorylation site [posttranslational modification] 158190003235 intermolecular recognition site; other site 158190003236 dimerization interface [polypeptide binding]; other site 158190003237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190003238 DNA binding site [nucleotide binding] 158190003239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190003240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190003241 active site 158190003242 phosphorylation site [posttranslational modification] 158190003243 intermolecular recognition site; other site 158190003244 dimerization interface [polypeptide binding]; other site 158190003245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190003246 DNA binding site [nucleotide binding] 158190003247 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 158190003248 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 158190003249 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 158190003250 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 158190003251 putative catalytic cysteine [active] 158190003252 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 158190003253 putative active site [active] 158190003254 metal binding site [ion binding]; metal-binding site 158190003255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190003256 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 158190003257 active site 158190003258 motif I; other site 158190003259 motif II; other site 158190003260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190003261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190003262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190003263 putative substrate translocation pore; other site 158190003264 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 158190003265 Rubrerythrin [Energy production and conversion]; Region: COG1592 158190003266 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 158190003267 iron binding site [ion binding]; other site 158190003268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190003269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190003270 non-specific DNA binding site [nucleotide binding]; other site 158190003271 salt bridge; other site 158190003272 sequence-specific DNA binding site [nucleotide binding]; other site 158190003273 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 158190003274 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 158190003275 PYR/PP interface [polypeptide binding]; other site 158190003276 dimer interface [polypeptide binding]; other site 158190003277 TPP binding site [chemical binding]; other site 158190003278 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 158190003279 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 158190003280 TPP-binding site [chemical binding]; other site 158190003281 dimer interface [polypeptide binding]; other site 158190003282 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 158190003283 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 158190003284 tartrate dehydrogenase; Region: TTC; TIGR02089 158190003285 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 158190003286 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 158190003287 substrate binding site [chemical binding]; other site 158190003288 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 158190003289 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 158190003290 substrate binding site [chemical binding]; other site 158190003291 ligand binding site [chemical binding]; other site 158190003292 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 158190003293 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 158190003294 active site 158190003295 catalytic residues [active] 158190003296 metal binding site [ion binding]; metal-binding site 158190003297 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 158190003298 2-isopropylmalate synthase; Validated; Region: PRK00915 158190003299 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 158190003300 active site 158190003301 catalytic residues [active] 158190003302 metal binding site [ion binding]; metal-binding site 158190003303 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 158190003304 ketol-acid reductoisomerase; Provisional; Region: PRK05479 158190003305 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 158190003306 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 158190003307 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 158190003308 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 158190003309 putative valine binding site [chemical binding]; other site 158190003310 dimer interface [polypeptide binding]; other site 158190003311 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 158190003312 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 158190003313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190003314 dimerization interface [polypeptide binding]; other site 158190003315 Histidine kinase; Region: His_kinase; pfam06580 158190003316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190003317 ATP binding site [chemical binding]; other site 158190003318 Mg2+ binding site [ion binding]; other site 158190003319 G-X-G motif; other site 158190003320 Response regulator receiver domain; Region: Response_reg; pfam00072 158190003321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190003322 active site 158190003323 phosphorylation site [posttranslational modification] 158190003324 intermolecular recognition site; other site 158190003325 dimerization interface [polypeptide binding]; other site 158190003326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190003327 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190003328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190003329 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 158190003330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190003331 motif II; other site 158190003332 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190003333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190003334 dimer interface [polypeptide binding]; other site 158190003335 conserved gate region; other site 158190003336 putative PBP binding loops; other site 158190003337 ABC-ATPase subunit interface; other site 158190003338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190003339 dimer interface [polypeptide binding]; other site 158190003340 conserved gate region; other site 158190003341 putative PBP binding loops; other site 158190003342 ABC-ATPase subunit interface; other site 158190003343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190003344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190003345 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 158190003346 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 158190003347 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 158190003348 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 158190003349 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 158190003350 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 158190003351 G1 box; other site 158190003352 GTP/Mg2+ binding site [chemical binding]; other site 158190003353 Switch I region; other site 158190003354 G2 box; other site 158190003355 G3 box; other site 158190003356 Switch II region; other site 158190003357 G4 box; other site 158190003358 G5 box; other site 158190003359 Nucleoside recognition; Region: Gate; pfam07670 158190003360 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 158190003361 Nucleoside recognition; Region: Gate; pfam07670 158190003362 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158190003363 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190003364 substrate binding pocket [chemical binding]; other site 158190003365 membrane-bound complex binding site; other site 158190003366 hinge residues; other site 158190003367 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 158190003368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190003369 dimer interface [polypeptide binding]; other site 158190003370 conserved gate region; other site 158190003371 putative PBP binding loops; other site 158190003372 ABC-ATPase subunit interface; other site 158190003373 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158190003374 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158190003375 Walker A/P-loop; other site 158190003376 ATP binding site [chemical binding]; other site 158190003377 Q-loop/lid; other site 158190003378 ABC transporter signature motif; other site 158190003379 Walker B; other site 158190003380 D-loop; other site 158190003381 H-loop/switch region; other site 158190003382 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 158190003383 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 158190003384 active site 158190003385 putative substrate binding pocket [chemical binding]; other site 158190003386 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190003387 Helix-turn-helix domain; Region: HTH_17; pfam12728 158190003388 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 158190003389 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 158190003390 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 158190003391 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 158190003392 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158190003393 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 158190003394 active site 158190003395 tetramer interface [polypeptide binding]; other site 158190003396 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 158190003397 dimer interface [polypeptide binding]; other site 158190003398 FMN binding site [chemical binding]; other site 158190003399 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158190003400 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 158190003401 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190003402 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190003403 TM-ABC transporter signature motif; other site 158190003404 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190003405 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190003406 TM-ABC transporter signature motif; other site 158190003407 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190003408 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190003409 Walker A/P-loop; other site 158190003410 ATP binding site [chemical binding]; other site 158190003411 Q-loop/lid; other site 158190003412 ABC transporter signature motif; other site 158190003413 Walker B; other site 158190003414 D-loop; other site 158190003415 H-loop/switch region; other site 158190003416 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190003417 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190003418 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 158190003419 ligand binding site [chemical binding]; other site 158190003420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190003421 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 158190003422 active site 158190003423 motif I; other site 158190003424 motif II; other site 158190003425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 158190003426 motif I; other site 158190003427 motif II; other site 158190003428 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 158190003429 SurA N-terminal domain; Region: SurA_N_3; cl07813 158190003430 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 158190003431 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 158190003432 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158190003433 putative active site [active] 158190003434 putative metal binding site [ion binding]; other site 158190003435 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 158190003436 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 158190003437 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158190003438 ATP binding site [chemical binding]; other site 158190003439 Mg++ binding site [ion binding]; other site 158190003440 motif III; other site 158190003441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190003442 nucleotide binding region [chemical binding]; other site 158190003443 ATP-binding site [chemical binding]; other site 158190003444 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 158190003445 RNA binding site [nucleotide binding]; other site 158190003446 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 158190003447 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 158190003448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190003449 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158190003450 monogalactosyldiacylglycerol synthase; Region: PLN02605 158190003451 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158190003452 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 158190003453 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 158190003454 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 158190003455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 158190003456 active site 158190003457 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 158190003458 Bacterial sugar transferase; Region: Bac_transf; pfam02397 158190003459 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 158190003460 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 158190003461 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 158190003462 Ligand binding site; other site 158190003463 metal-binding site 158190003464 Trp repressor protein; Region: Trp_repressor; cl17266 158190003465 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 158190003466 diiron binding motif [ion binding]; other site 158190003467 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 158190003468 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158190003469 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158190003470 active site 158190003471 catalytic tetrad [active] 158190003472 EamA-like transporter family; Region: EamA; pfam00892 158190003473 Predicted permeases [General function prediction only]; Region: COG0679 158190003474 xylose isomerase; Provisional; Region: PRK05474 158190003475 xylose isomerase; Region: xylose_isom_A; TIGR02630 158190003476 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 158190003477 N- and C-terminal domain interface [polypeptide binding]; other site 158190003478 D-xylulose kinase; Region: XylB; TIGR01312 158190003479 active site 158190003480 MgATP binding site [chemical binding]; other site 158190003481 catalytic site [active] 158190003482 metal binding site [ion binding]; metal-binding site 158190003483 xylulose binding site [chemical binding]; other site 158190003484 putative homodimer interface [polypeptide binding]; other site 158190003485 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158190003486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190003487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190003488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190003489 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158190003490 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 158190003491 substrate binding site [chemical binding]; other site 158190003492 dimer interface [polypeptide binding]; other site 158190003493 ATP binding site [chemical binding]; other site 158190003494 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 158190003495 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 158190003496 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 158190003497 putative active site [active] 158190003498 catalytic site [active] 158190003499 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 158190003500 putative active site [active] 158190003501 catalytic site [active] 158190003502 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 158190003503 Ligand Binding Site [chemical binding]; other site 158190003504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190003505 binding surface 158190003506 TPR motif; other site 158190003507 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 158190003508 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 158190003509 active site 158190003510 nucleophile elbow; other site 158190003511 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158190003512 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 158190003513 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158190003514 active site 158190003515 DNA binding site [nucleotide binding] 158190003516 Int/Topo IB signature motif; other site 158190003517 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158190003518 active site 158190003519 DNA binding site [nucleotide binding] 158190003520 Int/Topo IB signature motif; other site 158190003521 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 158190003522 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 158190003523 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158190003524 active site 158190003525 DNA binding site [nucleotide binding] 158190003526 Int/Topo IB signature motif; other site 158190003527 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 158190003528 AAA domain; Region: AAA_30; pfam13604 158190003529 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 158190003530 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 158190003531 Preprotein binding site; other site 158190003532 SecA binding site; other site 158190003533 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 158190003534 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 158190003535 Low molecular weight phosphatase family; Region: LMWPc; cd00115 158190003536 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 158190003537 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 158190003538 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 158190003539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190003540 dimerization interface [polypeptide binding]; other site 158190003541 putative DNA binding site [nucleotide binding]; other site 158190003542 putative Zn2+ binding site [ion binding]; other site 158190003543 Predicted integral membrane protein [Function unknown]; Region: COG5658 158190003544 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 158190003545 SdpI/YhfL protein family; Region: SdpI; pfam13630 158190003546 YceG-like family; Region: YceG; pfam02618 158190003547 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 158190003548 dimerization interface [polypeptide binding]; other site 158190003549 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 158190003550 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 158190003551 RNA binding site [nucleotide binding]; other site 158190003552 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 158190003553 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 158190003554 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 158190003555 dimer interface [polypeptide binding]; other site 158190003556 active site 158190003557 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158190003558 catalytic residues [active] 158190003559 substrate binding site [chemical binding]; other site 158190003560 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 158190003561 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158190003562 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158190003563 Walker A/P-loop; other site 158190003564 ATP binding site [chemical binding]; other site 158190003565 Q-loop/lid; other site 158190003566 ABC transporter signature motif; other site 158190003567 Walker B; other site 158190003568 D-loop; other site 158190003569 H-loop/switch region; other site 158190003570 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 158190003571 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158190003572 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158190003573 Walker A/P-loop; other site 158190003574 ATP binding site [chemical binding]; other site 158190003575 Q-loop/lid; other site 158190003576 ABC transporter signature motif; other site 158190003577 Walker B; other site 158190003578 D-loop; other site 158190003579 H-loop/switch region; other site 158190003580 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 158190003581 hypothetical protein; Provisional; Region: PRK13661 158190003582 Uncharacterized conserved protein [Function unknown]; Region: COG1912 158190003583 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 158190003584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190003585 motif II; other site 158190003586 cobalamin synthase; Reviewed; Region: cobS; PRK00235 158190003587 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 158190003588 homotrimer interface [polypeptide binding]; other site 158190003589 Walker A motif; other site 158190003590 GTP binding site [chemical binding]; other site 158190003591 Walker B motif; other site 158190003592 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158190003593 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158190003594 Metal-binding active site; metal-binding site 158190003595 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 158190003596 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 158190003597 active site pocket [active] 158190003598 putative dimer interface [polypeptide binding]; other site 158190003599 putative cataytic base [active] 158190003600 Protein of unknown function, DUF606; Region: DUF606; pfam04657 158190003601 Protein of unknown function, DUF606; Region: DUF606; cl01273 158190003602 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158190003603 endonuclease III; Region: ENDO3c; smart00478 158190003604 minor groove reading motif; other site 158190003605 helix-hairpin-helix signature motif; other site 158190003606 substrate binding pocket [chemical binding]; other site 158190003607 active site 158190003608 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 158190003609 Domain of unknown function DUF20; Region: UPF0118; pfam01594 158190003610 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 158190003611 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 158190003612 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 158190003613 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 158190003614 putative active site [active] 158190003615 catalytic site [active] 158190003616 putative metal binding site [ion binding]; other site 158190003617 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 158190003618 Uncharacterized conserved protein [Function unknown]; Region: COG2006 158190003619 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190003620 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158190003621 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 158190003622 active site 158190003623 trimer interface [polypeptide binding]; other site 158190003624 allosteric site; other site 158190003625 active site lid [active] 158190003626 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158190003627 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 158190003628 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 158190003629 Ligand Binding Site [chemical binding]; other site 158190003630 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 158190003631 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158190003632 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190003633 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 158190003634 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 158190003635 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 158190003636 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 158190003637 catalytic loop [active] 158190003638 iron binding site [ion binding]; other site 158190003639 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158190003640 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 158190003641 active site 158190003642 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 158190003643 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 158190003644 active site 158190003645 catalytic site [active] 158190003646 substrate binding site [chemical binding]; other site 158190003647 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 158190003648 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 158190003649 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 158190003650 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 158190003651 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 158190003652 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 158190003653 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 158190003654 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 158190003655 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158190003656 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158190003657 acyl-activating enzyme (AAE) consensus motif; other site 158190003658 acyl-activating enzyme (AAE) consensus motif; other site 158190003659 AMP binding site [chemical binding]; other site 158190003660 active site 158190003661 CoA binding site [chemical binding]; other site 158190003662 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 158190003663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190003664 DNA-binding site [nucleotide binding]; DNA binding site 158190003665 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 158190003666 Uncharacterized conserved protein [Function unknown]; Region: COG3461 158190003667 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 158190003668 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 158190003669 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 158190003670 Walker A/P-loop; other site 158190003671 ATP binding site [chemical binding]; other site 158190003672 Q-loop/lid; other site 158190003673 ABC transporter signature motif; other site 158190003674 Walker B; other site 158190003675 D-loop; other site 158190003676 H-loop/switch region; other site 158190003677 TOBE domain; Region: TOBE_2; pfam08402 158190003678 aspartate kinase; Reviewed; Region: PRK09034 158190003679 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 158190003680 nucleotide binding site [chemical binding]; other site 158190003681 substrate binding site [chemical binding]; other site 158190003682 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 158190003683 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 158190003684 putative efflux protein, MATE family; Region: matE; TIGR00797 158190003685 GMP synthase; Reviewed; Region: guaA; PRK00074 158190003686 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 158190003687 AMP/PPi binding site [chemical binding]; other site 158190003688 candidate oxyanion hole; other site 158190003689 catalytic triad [active] 158190003690 potential glutamine specificity residues [chemical binding]; other site 158190003691 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 158190003692 ATP Binding subdomain [chemical binding]; other site 158190003693 Ligand Binding sites [chemical binding]; other site 158190003694 Dimerization subdomain; other site 158190003695 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 158190003696 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 158190003697 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158190003698 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158190003699 Walker A/P-loop; other site 158190003700 ATP binding site [chemical binding]; other site 158190003701 Q-loop/lid; other site 158190003702 ABC transporter signature motif; other site 158190003703 Walker B; other site 158190003704 D-loop; other site 158190003705 H-loop/switch region; other site 158190003706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190003707 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 158190003708 Walker A/P-loop; other site 158190003709 ATP binding site [chemical binding]; other site 158190003710 Q-loop/lid; other site 158190003711 ABC transporter signature motif; other site 158190003712 Walker B; other site 158190003713 D-loop; other site 158190003714 H-loop/switch region; other site 158190003715 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158190003716 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158190003717 putative acyl-acceptor binding pocket; other site 158190003718 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158190003719 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158190003720 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 158190003721 Walker A/P-loop; other site 158190003722 ATP binding site [chemical binding]; other site 158190003723 Q-loop/lid; other site 158190003724 ABC transporter signature motif; other site 158190003725 Walker B; other site 158190003726 D-loop; other site 158190003727 H-loop/switch region; other site 158190003728 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 158190003729 DEAD-like helicases superfamily; Region: DEXDc; smart00487 158190003730 ATP binding site [chemical binding]; other site 158190003731 Mg++ binding site [ion binding]; other site 158190003732 motif III; other site 158190003733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190003734 nucleotide binding region [chemical binding]; other site 158190003735 ATP-binding site [chemical binding]; other site 158190003736 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 158190003737 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 158190003738 homodimer interface [polypeptide binding]; other site 158190003739 substrate-cofactor binding pocket; other site 158190003740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190003741 catalytic residue [active] 158190003742 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 158190003743 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 158190003744 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 158190003745 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 158190003746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190003747 S-adenosylmethionine binding site [chemical binding]; other site 158190003748 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 158190003749 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 158190003750 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 158190003751 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 158190003752 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 158190003753 trmE is a tRNA modification GTPase; Region: trmE; cd04164 158190003754 G1 box; other site 158190003755 GTP/Mg2+ binding site [chemical binding]; other site 158190003756 Switch I region; other site 158190003757 G2 box; other site 158190003758 Switch II region; other site 158190003759 G3 box; other site 158190003760 G4 box; other site 158190003761 G5 box; other site 158190003762 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 158190003763 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 158190003764 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 158190003765 motif 1; other site 158190003766 dimer interface [polypeptide binding]; other site 158190003767 active site 158190003768 motif 2; other site 158190003769 motif 3; other site 158190003770 elongation factor P; Validated; Region: PRK00529 158190003771 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 158190003772 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 158190003773 RNA binding site [nucleotide binding]; other site 158190003774 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 158190003775 RNA binding site [nucleotide binding]; other site 158190003776 hybrid cluster protein; Provisional; Region: PRK05290 158190003777 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190003778 ACS interaction site; other site 158190003779 CODH interaction site; other site 158190003780 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 158190003781 hybrid metal cluster; other site 158190003782 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 158190003783 Predicted membrane protein [Function unknown]; Region: COG1971 158190003784 Domain of unknown function DUF; Region: DUF204; pfam02659 158190003785 Domain of unknown function DUF; Region: DUF204; pfam02659 158190003786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190003787 MFS/sugar transport protein; Region: MFS_2; pfam13347 158190003788 putative substrate translocation pore; other site 158190003789 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 158190003790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190003791 FeS/SAM binding site; other site 158190003792 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 158190003793 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 158190003794 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 158190003795 CoA-binding site [chemical binding]; other site 158190003796 ATP-binding [chemical binding]; other site 158190003797 DNA polymerase I; Provisional; Region: PRK05755 158190003798 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 158190003799 active site 158190003800 metal binding site 1 [ion binding]; metal-binding site 158190003801 putative 5' ssDNA interaction site; other site 158190003802 metal binding site 3; metal-binding site 158190003803 metal binding site 2 [ion binding]; metal-binding site 158190003804 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 158190003805 putative DNA binding site [nucleotide binding]; other site 158190003806 putative metal binding site [ion binding]; other site 158190003807 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 158190003808 active site 158190003809 catalytic site [active] 158190003810 substrate binding site [chemical binding]; other site 158190003811 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 158190003812 active site 158190003813 DNA binding site [nucleotide binding] 158190003814 catalytic site [active] 158190003815 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 158190003816 putative hydrolase; Provisional; Region: PRK02113 158190003817 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 158190003818 NAD synthetase; Reviewed; Region: nadE; PRK02628 158190003819 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 158190003820 multimer interface [polypeptide binding]; other site 158190003821 active site 158190003822 catalytic triad [active] 158190003823 protein interface 1 [polypeptide binding]; other site 158190003824 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 158190003825 homodimer interface [polypeptide binding]; other site 158190003826 NAD binding pocket [chemical binding]; other site 158190003827 ATP binding pocket [chemical binding]; other site 158190003828 Mg binding site [ion binding]; other site 158190003829 active-site loop [active] 158190003830 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 158190003831 TRAM domain; Region: TRAM; cl01282 158190003832 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 158190003833 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 158190003834 Zn binding site [ion binding]; other site 158190003835 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 158190003836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190003837 active site 158190003838 phosphorylation site [posttranslational modification] 158190003839 intermolecular recognition site; other site 158190003840 dimerization interface [polypeptide binding]; other site 158190003841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190003842 Walker A motif; other site 158190003843 ATP binding site [chemical binding]; other site 158190003844 Walker B motif; other site 158190003845 arginine finger; other site 158190003846 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 158190003847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190003848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190003849 dimer interface [polypeptide binding]; other site 158190003850 phosphorylation site [posttranslational modification] 158190003851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190003852 ATP binding site [chemical binding]; other site 158190003853 Mg2+ binding site [ion binding]; other site 158190003854 G-X-G motif; other site 158190003855 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158190003856 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 158190003857 FtsX-like permease family; Region: FtsX; pfam02687 158190003858 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158190003859 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158190003860 Walker A/P-loop; other site 158190003861 ATP binding site [chemical binding]; other site 158190003862 Q-loop/lid; other site 158190003863 ABC transporter signature motif; other site 158190003864 Walker B; other site 158190003865 D-loop; other site 158190003866 H-loop/switch region; other site 158190003867 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 158190003868 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 158190003869 HlyD family secretion protein; Region: HlyD_3; pfam13437 158190003870 pteridine reductase; Provisional; Region: PRK09135 158190003871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190003872 NAD(P) binding site [chemical binding]; other site 158190003873 active site 158190003874 FtsH Extracellular; Region: FtsH_ext; pfam06480 158190003875 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 158190003876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190003877 Walker A motif; other site 158190003878 ATP binding site [chemical binding]; other site 158190003879 Walker B motif; other site 158190003880 arginine finger; other site 158190003881 Peptidase family M41; Region: Peptidase_M41; pfam01434 158190003882 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 158190003883 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 158190003884 dimerization interface [polypeptide binding]; other site 158190003885 domain crossover interface; other site 158190003886 redox-dependent activation switch; other site 158190003887 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 158190003888 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 158190003889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 158190003890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190003891 S-adenosylmethionine binding site [chemical binding]; other site 158190003892 Methyltransferase domain; Region: Methyltransf_23; pfam13489 158190003893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190003894 S-adenosylmethionine binding site [chemical binding]; other site 158190003895 CpXC protein; Region: CpXC; pfam14353 158190003896 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 158190003897 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 158190003898 putative ligand binding site [chemical binding]; other site 158190003899 putative NAD binding site [chemical binding]; other site 158190003900 catalytic site [active] 158190003901 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 158190003902 dinuclear metal binding motif [ion binding]; other site 158190003903 Fic/DOC family; Region: Fic; cl00960 158190003904 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 158190003905 Uncharacterized conserved protein [Function unknown]; Region: COG1284 158190003906 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 158190003907 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 158190003908 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 158190003909 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158190003910 active site 158190003911 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 158190003912 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 158190003913 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 158190003914 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 158190003915 YmdB-like protein; Region: YmdB; pfam13277 158190003916 active site 158190003917 metal binding site [ion binding]; metal-binding site 158190003918 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 158190003919 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 158190003920 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 158190003921 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 158190003922 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 158190003923 Walker A/P-loop; other site 158190003924 ATP binding site [chemical binding]; other site 158190003925 Q-loop/lid; other site 158190003926 ABC transporter signature motif; other site 158190003927 Walker B; other site 158190003928 D-loop; other site 158190003929 H-loop/switch region; other site 158190003930 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 158190003931 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 158190003932 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 158190003933 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 158190003934 30S subunit binding site; other site 158190003935 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 158190003936 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 158190003937 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 158190003938 Hpr binding site; other site 158190003939 active site 158190003940 homohexamer subunit interaction site [polypeptide binding]; other site 158190003941 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 158190003942 dimerization domain swap beta strand [polypeptide binding]; other site 158190003943 regulatory protein interface [polypeptide binding]; other site 158190003944 active site 158190003945 regulatory phosphorylation site [posttranslational modification]; other site 158190003946 LexA repressor; Validated; Region: PRK00215 158190003947 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 158190003948 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 158190003949 Catalytic site [active] 158190003950 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 158190003951 DNA polymerase III, delta subunit; Region: holA; TIGR01128 158190003952 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 158190003953 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 158190003954 GIY-YIG motif/motif A; other site 158190003955 active site 158190003956 catalytic site [active] 158190003957 putative DNA binding site [nucleotide binding]; other site 158190003958 metal binding site [ion binding]; metal-binding site 158190003959 UvrB/uvrC motif; Region: UVR; pfam02151 158190003960 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 158190003961 Radical SAM superfamily; Region: Radical_SAM; pfam04055 158190003962 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 158190003963 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 158190003964 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 158190003965 RNA methyltransferase, RsmE family; Region: TIGR00046 158190003966 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 158190003967 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 158190003968 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 158190003969 4-alpha-glucanotransferase; Provisional; Region: PRK14508 158190003970 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 158190003971 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 158190003972 substrate binding site; other site 158190003973 dimer interface; other site 158190003974 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 158190003975 homotrimer interaction site [polypeptide binding]; other site 158190003976 zinc binding site [ion binding]; other site 158190003977 CDP-binding sites; other site 158190003978 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 158190003979 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190003980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190003981 non-specific DNA binding site [nucleotide binding]; other site 158190003982 salt bridge; other site 158190003983 sequence-specific DNA binding site [nucleotide binding]; other site 158190003984 Predicted transcriptional regulator [Transcription]; Region: COG2932 158190003985 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 158190003986 Catalytic site [active] 158190003987 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 158190003988 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 158190003989 active site 158190003990 catalytic triad [active] 158190003991 Src homology 2 (SH2) domain; Region: SH2; cl15255 158190003992 phosphotyrosine binding pocket [polypeptide binding]; other site 158190003993 hydrophobic binding pocket [polypeptide binding]; other site 158190003994 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 158190003995 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 158190003996 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 158190003997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 158190003998 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158190003999 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158190004000 putative acyl-acceptor binding pocket; other site 158190004001 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 158190004002 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158190004003 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158190004004 Walker A/P-loop; other site 158190004005 ATP binding site [chemical binding]; other site 158190004006 Q-loop/lid; other site 158190004007 ABC transporter signature motif; other site 158190004008 Walker B; other site 158190004009 D-loop; other site 158190004010 H-loop/switch region; other site 158190004011 Predicted transcriptional regulators [Transcription]; Region: COG1725 158190004012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190004013 DNA-binding site [nucleotide binding]; DNA binding site 158190004014 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 158190004015 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 158190004016 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 158190004017 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158190004018 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158190004019 Walker A/P-loop; other site 158190004020 ATP binding site [chemical binding]; other site 158190004021 Q-loop/lid; other site 158190004022 ABC transporter signature motif; other site 158190004023 Walker B; other site 158190004024 D-loop; other site 158190004025 H-loop/switch region; other site 158190004026 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 158190004027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190004028 Walker A/P-loop; other site 158190004029 ATP binding site [chemical binding]; other site 158190004030 ABC transporter; Region: ABC_tran; pfam00005 158190004031 Q-loop/lid; other site 158190004032 ABC transporter signature motif; other site 158190004033 Walker B; other site 158190004034 D-loop; other site 158190004035 H-loop/switch region; other site 158190004036 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 158190004037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004038 putative PBP binding loops; other site 158190004039 dimer interface [polypeptide binding]; other site 158190004040 ABC-ATPase subunit interface; other site 158190004041 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 158190004042 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190004043 MOSC domain; Region: MOSC; pfam03473 158190004044 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 158190004045 MPT binding site; other site 158190004046 trimer interface [polypeptide binding]; other site 158190004047 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 158190004048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190004049 FeS/SAM binding site; other site 158190004050 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 158190004051 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 158190004052 trimer interface [polypeptide binding]; other site 158190004053 dimer interface [polypeptide binding]; other site 158190004054 putative active site [active] 158190004055 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 158190004056 putative MPT binding site; other site 158190004057 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 158190004058 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190004059 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190004060 nucleotide binding site [chemical binding]; other site 158190004061 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 158190004062 dimer interface [polypeptide binding]; other site 158190004063 active site 158190004064 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158190004065 MarR family; Region: MarR; pfam01047 158190004066 MarR family; Region: MarR_2; cl17246 158190004067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004068 dimer interface [polypeptide binding]; other site 158190004069 conserved gate region; other site 158190004070 putative PBP binding loops; other site 158190004071 ABC-ATPase subunit interface; other site 158190004072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158190004073 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190004074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004075 dimer interface [polypeptide binding]; other site 158190004076 conserved gate region; other site 158190004077 putative PBP binding loops; other site 158190004078 ABC-ATPase subunit interface; other site 158190004079 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190004080 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190004081 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 158190004082 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 158190004083 DNA binding residues [nucleotide binding] 158190004084 hypothetical protein; Reviewed; Region: PRK00024 158190004085 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 158190004086 MPN+ (JAMM) motif; other site 158190004087 Zinc-binding site [ion binding]; other site 158190004088 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 158190004089 Predicted transcriptional regulator [Transcription]; Region: COG2378 158190004090 HTH domain; Region: HTH_11; pfam08279 158190004091 WYL domain; Region: WYL; pfam13280 158190004092 Isochorismatase family; Region: Isochorismatase; pfam00857 158190004093 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 158190004094 catalytic triad [active] 158190004095 conserved cis-peptide bond; other site 158190004096 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 158190004097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158190004098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158190004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158190004100 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 158190004101 active site residue [active] 158190004102 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 158190004103 active site residue [active] 158190004104 SnoaL-like domain; Region: SnoaL_2; pfam12680 158190004105 oxidoreductase; Provisional; Region: PRK06196 158190004106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190004107 NAD(P) binding site [chemical binding]; other site 158190004108 active site 158190004109 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 158190004110 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 158190004111 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 158190004112 metal binding site [ion binding]; metal-binding site 158190004113 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 158190004114 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 158190004115 substrate binding site [chemical binding]; other site 158190004116 glutamase interaction surface [polypeptide binding]; other site 158190004117 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 158190004118 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 158190004119 catalytic residues [active] 158190004120 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 158190004121 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 158190004122 putative active site [active] 158190004123 oxyanion strand; other site 158190004124 catalytic triad [active] 158190004125 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 158190004126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190004127 active site 158190004128 motif I; other site 158190004129 motif II; other site 158190004130 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 158190004131 putative active site pocket [active] 158190004132 4-fold oligomerization interface [polypeptide binding]; other site 158190004133 metal binding residues [ion binding]; metal-binding site 158190004134 3-fold/trimer interface [polypeptide binding]; other site 158190004135 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 158190004136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158190004137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190004138 homodimer interface [polypeptide binding]; other site 158190004139 catalytic residue [active] 158190004140 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 158190004141 histidinol dehydrogenase; Region: hisD; TIGR00069 158190004142 NAD binding site [chemical binding]; other site 158190004143 dimerization interface [polypeptide binding]; other site 158190004144 product binding site; other site 158190004145 substrate binding site [chemical binding]; other site 158190004146 zinc binding site [ion binding]; other site 158190004147 catalytic residues [active] 158190004148 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 158190004149 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 158190004150 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 158190004151 RelB antitoxin; Region: RelB; cl01171 158190004152 Nitrogen regulatory protein P-II; Region: P-II; cl00412 158190004153 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158190004154 active site 158190004155 phosphorylation site [posttranslational modification] 158190004156 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 158190004157 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 158190004158 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 158190004159 hypothetical protein; Provisional; Region: PRK08378 158190004160 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 158190004161 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 158190004162 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 158190004163 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 158190004164 N-acetylneuraminate lyase; Provisional; Region: PRK04147 158190004165 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158190004166 inhibitor site; inhibition site 158190004167 active site 158190004168 dimer interface [polypeptide binding]; other site 158190004169 catalytic residue [active] 158190004170 D-mannonate oxidoreductase; Provisional; Region: PRK08277 158190004171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190004172 NAD(P) binding site [chemical binding]; other site 158190004173 active site 158190004174 DctM-like transporters; Region: DctM; pfam06808 158190004175 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190004176 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 158190004177 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190004178 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158190004179 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190004180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190004181 DNA-binding site [nucleotide binding]; DNA binding site 158190004182 FCD domain; Region: FCD; pfam07729 158190004183 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616 158190004184 tRNA synthetase B5 domain; Region: B5; smart00874 158190004185 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 158190004186 dimer interface [polypeptide binding]; other site 158190004187 motif 1; other site 158190004188 motif 3; other site 158190004189 motif 2; other site 158190004190 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 158190004191 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 158190004192 dimer interface [polypeptide binding]; other site 158190004193 motif 1; other site 158190004194 active site 158190004195 motif 2; other site 158190004196 motif 3; other site 158190004197 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 158190004198 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 158190004199 tetramer interface [polypeptide binding]; other site 158190004200 TPP-binding site [chemical binding]; other site 158190004201 heterodimer interface [polypeptide binding]; other site 158190004202 phosphorylation loop region [posttranslational modification] 158190004203 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 158190004204 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 158190004205 alpha subunit interface [polypeptide binding]; other site 158190004206 TPP binding site [chemical binding]; other site 158190004207 heterodimer interface [polypeptide binding]; other site 158190004208 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158190004209 Flavin Reductases; Region: FlaRed; cl00801 158190004210 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158190004211 active site 158190004212 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 158190004213 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158190004214 active site 158190004215 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 158190004216 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 158190004217 GDP-binding site [chemical binding]; other site 158190004218 ACT binding site; other site 158190004219 IMP binding site; other site 158190004220 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158190004221 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158190004222 Walker A/P-loop; other site 158190004223 ATP binding site [chemical binding]; other site 158190004224 Q-loop/lid; other site 158190004225 ABC transporter signature motif; other site 158190004226 Walker B; other site 158190004227 D-loop; other site 158190004228 H-loop/switch region; other site 158190004229 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 158190004230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004231 dimer interface [polypeptide binding]; other site 158190004232 conserved gate region; other site 158190004233 putative PBP binding loops; other site 158190004234 ABC-ATPase subunit interface; other site 158190004235 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190004236 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 158190004237 substrate binding pocket [chemical binding]; other site 158190004238 membrane-bound complex binding site; other site 158190004239 hinge residues; other site 158190004240 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190004241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190004242 DNA-binding site [nucleotide binding]; DNA binding site 158190004243 FCD domain; Region: FCD; cl11656 158190004244 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158190004245 4Fe-4S binding domain; Region: Fer4; pfam00037 158190004246 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 158190004247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158190004248 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 158190004249 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 158190004250 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 158190004251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190004252 S-adenosylmethionine binding site [chemical binding]; other site 158190004253 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190004254 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 158190004255 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 158190004256 DNA binding residues [nucleotide binding] 158190004257 Uncharacterized conserved protein [Function unknown]; Region: COG1433 158190004258 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 158190004259 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 158190004260 P loop nucleotide binding; other site 158190004261 switch II; other site 158190004262 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 158190004263 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190004264 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 158190004265 switch II; other site 158190004266 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 158190004267 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 158190004268 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 158190004269 Walker A motif; other site 158190004270 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 158190004271 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 158190004272 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 158190004273 active site 158190004274 dimer interface [polypeptide binding]; other site 158190004275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158190004276 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158190004277 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158190004278 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190004279 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 158190004280 Walker A/P-loop; other site 158190004281 ATP binding site [chemical binding]; other site 158190004282 Q-loop/lid; other site 158190004283 ABC transporter signature motif; other site 158190004284 Walker B; other site 158190004285 D-loop; other site 158190004286 H-loop/switch region; other site 158190004287 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158190004288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004289 dimer interface [polypeptide binding]; other site 158190004290 conserved gate region; other site 158190004291 putative PBP binding loops; other site 158190004292 ABC-ATPase subunit interface; other site 158190004293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004294 dimer interface [polypeptide binding]; other site 158190004295 conserved gate region; other site 158190004296 putative PBP binding loops; other site 158190004297 ABC-ATPase subunit interface; other site 158190004298 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190004299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190004300 Walker A/P-loop; other site 158190004301 ATP binding site [chemical binding]; other site 158190004302 Q-loop/lid; other site 158190004303 ABC transporter signature motif; other site 158190004304 Walker B; other site 158190004305 D-loop; other site 158190004306 H-loop/switch region; other site 158190004307 TOBE domain; Region: TOBE_2; pfam08402 158190004308 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158190004309 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158190004310 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190004311 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190004312 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 158190004313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190004314 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 158190004315 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 158190004316 tetramer interface [polypeptide binding]; other site 158190004317 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 158190004318 classical (c) SDRs; Region: SDR_c; cd05233 158190004319 NAD(P) binding site [chemical binding]; other site 158190004320 active site 158190004321 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 158190004322 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 158190004323 Predicted membrane protein [Function unknown]; Region: COG2860 158190004324 UPF0126 domain; Region: UPF0126; pfam03458 158190004325 UPF0126 domain; Region: UPF0126; pfam03458 158190004326 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 158190004327 Malic enzyme, N-terminal domain; Region: malic; pfam00390 158190004328 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 158190004329 putative NAD(P) binding site [chemical binding]; other site 158190004330 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 158190004331 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158190004332 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158190004333 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158190004334 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 158190004335 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 158190004336 Walker A/P-loop; other site 158190004337 ATP binding site [chemical binding]; other site 158190004338 Q-loop/lid; other site 158190004339 ABC transporter signature motif; other site 158190004340 Walker B; other site 158190004341 D-loop; other site 158190004342 H-loop/switch region; other site 158190004343 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 158190004344 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 158190004345 Walker A/P-loop; other site 158190004346 ATP binding site [chemical binding]; other site 158190004347 Q-loop/lid; other site 158190004348 ABC transporter signature motif; other site 158190004349 Walker B; other site 158190004350 D-loop; other site 158190004351 H-loop/switch region; other site 158190004352 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190004353 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 158190004354 TM-ABC transporter signature motif; other site 158190004355 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190004356 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 158190004357 TM-ABC transporter signature motif; other site 158190004358 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 158190004359 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 158190004360 putative ligand binding site [chemical binding]; other site 158190004361 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 158190004362 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 158190004363 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 158190004364 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 158190004365 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 158190004366 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 158190004367 Melibiase; Region: Melibiase; pfam02065 158190004368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 158190004369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158190004370 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 158190004371 Coenzyme A binding pocket [chemical binding]; other site 158190004372 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 158190004373 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 158190004374 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 158190004375 Uncharacterized conserved protein [Function unknown]; Region: COG2968 158190004376 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 158190004377 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 158190004378 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 158190004379 dimer interface [polypeptide binding]; other site 158190004380 ADP-ribose binding site [chemical binding]; other site 158190004381 active site 158190004382 nudix motif; other site 158190004383 metal binding site [ion binding]; metal-binding site 158190004384 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 158190004385 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 158190004386 Walker A motif; other site 158190004387 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 158190004388 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 158190004389 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 158190004390 active site 158190004391 catalytic residues [active] 158190004392 metal binding site [ion binding]; metal-binding site 158190004393 homodimer binding site [polypeptide binding]; other site 158190004394 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 158190004395 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 158190004396 carboxyltransferase (CT) interaction site; other site 158190004397 biotinylation site [posttranslational modification]; other site 158190004398 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 158190004399 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158190004400 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 158190004401 PGAP1-like protein; Region: PGAP1; pfam07819 158190004402 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 158190004403 catalytic motif [active] 158190004404 Zn binding site [ion binding]; other site 158190004405 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 158190004406 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 158190004407 substrate binding site [chemical binding]; other site 158190004408 ATP binding site [chemical binding]; other site 158190004409 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190004410 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190004411 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190004412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190004413 Walker A/P-loop; other site 158190004414 ATP binding site [chemical binding]; other site 158190004415 Q-loop/lid; other site 158190004416 ABC transporter signature motif; other site 158190004417 Walker B; other site 158190004418 D-loop; other site 158190004419 H-loop/switch region; other site 158190004420 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190004421 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190004422 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190004423 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190004424 TM-ABC transporter signature motif; other site 158190004425 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190004426 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190004427 TM-ABC transporter signature motif; other site 158190004428 Abi-like protein; Region: Abi_2; pfam07751 158190004429 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 158190004430 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 158190004431 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158190004432 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158190004433 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190004434 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158190004435 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190004436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 158190004437 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 158190004438 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190004439 active site 158190004440 Purine nucleoside permease (NUP); Region: NUP; cl17832 158190004441 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 158190004442 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 158190004443 FMN binding site [chemical binding]; other site 158190004444 substrate binding site [chemical binding]; other site 158190004445 putative catalytic residue [active] 158190004446 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 158190004447 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 158190004448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158190004449 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 158190004450 Walker A/P-loop; other site 158190004451 ATP binding site [chemical binding]; other site 158190004452 Q-loop/lid; other site 158190004453 ABC transporter signature motif; other site 158190004454 Walker B; other site 158190004455 D-loop; other site 158190004456 H-loop/switch region; other site 158190004457 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 158190004458 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 158190004459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190004460 Walker A/P-loop; other site 158190004461 ATP binding site [chemical binding]; other site 158190004462 Q-loop/lid; other site 158190004463 ABC transporter signature motif; other site 158190004464 Walker B; other site 158190004465 D-loop; other site 158190004466 H-loop/switch region; other site 158190004467 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158190004468 MarR family; Region: MarR; pfam01047 158190004469 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 158190004470 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 158190004471 N- and C-terminal domain interface [polypeptide binding]; other site 158190004472 putative active site [active] 158190004473 MgATP binding site [chemical binding]; other site 158190004474 catalytic site [active] 158190004475 metal binding site [ion binding]; metal-binding site 158190004476 putative xylulose binding site [chemical binding]; other site 158190004477 putative homodimer interface [polypeptide binding]; other site 158190004478 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190004479 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 158190004480 active site 158190004481 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190004482 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190004483 TM-ABC transporter signature motif; other site 158190004484 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190004485 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190004486 TM-ABC transporter signature motif; other site 158190004487 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190004488 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190004489 Walker A/P-loop; other site 158190004490 ATP binding site [chemical binding]; other site 158190004491 Q-loop/lid; other site 158190004492 ABC transporter signature motif; other site 158190004493 Walker B; other site 158190004494 D-loop; other site 158190004495 H-loop/switch region; other site 158190004496 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190004497 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190004498 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 158190004499 ligand binding site [chemical binding]; other site 158190004500 BtpA family; Region: BtpA; cl00440 158190004501 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158190004502 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158190004503 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158190004504 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 158190004505 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 158190004506 putative active site [active] 158190004507 metal binding site [ion binding]; metal-binding site 158190004508 DctM-like transporters; Region: DctM; pfam06808 158190004509 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190004510 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158190004511 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190004512 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158190004513 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 158190004514 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 158190004515 substrate binding site [chemical binding]; other site 158190004516 hexamer interface [polypeptide binding]; other site 158190004517 metal binding site [ion binding]; metal-binding site 158190004518 KduI/IolB family; Region: KduI; cl01508 158190004519 Cupin domain; Region: Cupin_2; cl17218 158190004520 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190004521 DNA binding site [nucleotide binding] 158190004522 domain linker motif; other site 158190004523 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158190004524 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190004525 ligand binding site [chemical binding]; other site 158190004526 DctM-like transporters; Region: DctM; pfam06808 158190004527 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190004528 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158190004529 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190004530 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158190004531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190004532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190004533 dimerization interface [polypeptide binding]; other site 158190004534 Histidine kinase; Region: His_kinase; pfam06580 158190004535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190004536 ATP binding site [chemical binding]; other site 158190004537 Mg2+ binding site [ion binding]; other site 158190004538 G-X-G motif; other site 158190004539 Response regulator receiver domain; Region: Response_reg; pfam00072 158190004540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190004541 active site 158190004542 phosphorylation site [posttranslational modification] 158190004543 intermolecular recognition site; other site 158190004544 dimerization interface [polypeptide binding]; other site 158190004545 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190004546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190004547 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190004548 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190004549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004550 dimer interface [polypeptide binding]; other site 158190004551 conserved gate region; other site 158190004552 putative PBP binding loops; other site 158190004553 ABC-ATPase subunit interface; other site 158190004554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004555 dimer interface [polypeptide binding]; other site 158190004556 conserved gate region; other site 158190004557 putative PBP binding loops; other site 158190004558 ABC-ATPase subunit interface; other site 158190004559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190004560 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190004561 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158190004562 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158190004563 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158190004564 putative active site [active] 158190004565 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 158190004566 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 158190004567 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 158190004568 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158190004569 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 158190004570 substrate binding site [chemical binding]; other site 158190004571 ATP binding site [chemical binding]; other site 158190004572 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158190004573 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 158190004574 putative NAD(P) binding site [chemical binding]; other site 158190004575 catalytic Zn binding site [ion binding]; other site 158190004576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190004577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190004578 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190004579 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 158190004580 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 158190004581 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190004582 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190004583 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190004584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004585 dimer interface [polypeptide binding]; other site 158190004586 conserved gate region; other site 158190004587 ABC-ATPase subunit interface; other site 158190004588 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190004589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004590 dimer interface [polypeptide binding]; other site 158190004591 conserved gate region; other site 158190004592 putative PBP binding loops; other site 158190004593 ABC-ATPase subunit interface; other site 158190004594 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 158190004595 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 158190004596 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190004597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190004598 DNA-binding site [nucleotide binding]; DNA binding site 158190004599 FCD domain; Region: FCD; pfam07729 158190004600 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 158190004601 maltose phosphorylase; Provisional; Region: PRK13807 158190004602 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 158190004603 beta-phosphoglucomutase; Region: bPGM; TIGR01990 158190004604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190004605 motif II; other site 158190004606 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190004607 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190004608 DNA binding site [nucleotide binding] 158190004609 domain linker motif; other site 158190004610 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190004611 ligand binding site [chemical binding]; other site 158190004612 dimerization interface [polypeptide binding]; other site 158190004613 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158190004614 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158190004615 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158190004616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004617 dimer interface [polypeptide binding]; other site 158190004618 conserved gate region; other site 158190004619 putative PBP binding loops; other site 158190004620 ABC-ATPase subunit interface; other site 158190004621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004622 dimer interface [polypeptide binding]; other site 158190004623 conserved gate region; other site 158190004624 putative PBP binding loops; other site 158190004625 ABC-ATPase subunit interface; other site 158190004626 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190004627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190004628 Walker A/P-loop; other site 158190004629 ATP binding site [chemical binding]; other site 158190004630 Q-loop/lid; other site 158190004631 ABC transporter signature motif; other site 158190004632 Walker B; other site 158190004633 D-loop; other site 158190004634 H-loop/switch region; other site 158190004635 TOBE domain; Region: TOBE_2; pfam08402 158190004636 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 158190004637 active site 158190004638 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 158190004639 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 158190004640 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 158190004641 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158190004642 PYR/PP interface [polypeptide binding]; other site 158190004643 dimer interface [polypeptide binding]; other site 158190004644 TPP binding site [chemical binding]; other site 158190004645 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158190004646 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158190004647 TPP-binding site [chemical binding]; other site 158190004648 dimer interface [polypeptide binding]; other site 158190004649 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 158190004650 classical (c) SDRs; Region: SDR_c; cd05233 158190004651 NAD(P) binding site [chemical binding]; other site 158190004652 active site 158190004653 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 158190004654 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158190004655 NAD(P) binding site [chemical binding]; other site 158190004656 DctM-like transporters; Region: DctM; pfam06808 158190004657 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190004658 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 158190004659 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190004660 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 158190004661 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190004662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190004663 DNA-binding site [nucleotide binding]; DNA binding site 158190004664 FCD domain; Region: FCD; pfam07729 158190004665 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 158190004666 TIGR02452 family protein; Region: TIGR02452 158190004667 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 158190004668 Predicted acetyltransferase [General function prediction only]; Region: COG3393 158190004669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158190004670 transcriptional activator RhaR; Provisional; Region: PRK13502 158190004671 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158190004672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190004673 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 158190004674 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 158190004675 putative active site [active] 158190004676 metal binding site [ion binding]; metal-binding site 158190004677 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 158190004678 Sulfate transporter family; Region: Sulfate_transp; pfam00916 158190004679 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 158190004680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158190004681 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 158190004682 dimer interface [polypeptide binding]; other site 158190004683 active site 158190004684 metal binding site [ion binding]; metal-binding site 158190004685 glutathione binding site [chemical binding]; other site 158190004686 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 158190004687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 158190004688 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190004689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190004690 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 158190004691 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 158190004692 active site 158190004693 metal binding site [ion binding]; metal-binding site 158190004694 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 158190004695 active site 158190004696 catalytic triad [active] 158190004697 oxyanion hole [active] 158190004698 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190004699 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190004700 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 158190004701 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190004702 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190004703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004704 dimer interface [polypeptide binding]; other site 158190004705 conserved gate region; other site 158190004706 putative PBP binding loops; other site 158190004707 ABC-ATPase subunit interface; other site 158190004708 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 158190004709 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 158190004710 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 158190004711 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 158190004712 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158190004713 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158190004714 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 158190004715 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 158190004716 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 158190004717 carboxyltransferase (CT) interaction site; other site 158190004718 biotinylation site [posttranslational modification]; other site 158190004719 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 158190004720 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 158190004721 dimer interface [polypeptide binding]; other site 158190004722 active site 158190004723 CoA binding pocket [chemical binding]; other site 158190004724 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 158190004725 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 158190004726 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 158190004727 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 158190004728 NAD(P) binding site [chemical binding]; other site 158190004729 homotetramer interface [polypeptide binding]; other site 158190004730 homodimer interface [polypeptide binding]; other site 158190004731 active site 158190004732 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 158190004733 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 158190004734 dimer interface [polypeptide binding]; other site 158190004735 active site 158190004736 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 158190004737 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 158190004738 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 158190004739 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 158190004740 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 158190004741 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 158190004742 GAF domain; Region: GAF_3; pfam13492 158190004743 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190004744 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190004745 metal binding site [ion binding]; metal-binding site 158190004746 active site 158190004747 I-site; other site 158190004748 Chromate transporter; Region: Chromate_transp; pfam02417 158190004749 Chromate transporter; Region: Chromate_transp; pfam02417 158190004750 anaerobic sulfatase-maturase; Provisional; Region: PRK13758 158190004751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190004752 FeS/SAM binding site; other site 158190004753 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 158190004754 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 158190004755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190004756 DNA-binding site [nucleotide binding]; DNA binding site 158190004757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190004758 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190004759 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 158190004760 Sulfatase; Region: Sulfatase; pfam00884 158190004761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 158190004762 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 158190004763 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190004764 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190004765 DNA binding site [nucleotide binding] 158190004766 domain linker motif; other site 158190004767 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190004768 ligand binding site [chemical binding]; other site 158190004769 dimerization interface [polypeptide binding]; other site 158190004770 Sulfatase; Region: Sulfatase; cl17466 158190004771 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 158190004772 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190004773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004774 dimer interface [polypeptide binding]; other site 158190004775 conserved gate region; other site 158190004776 putative PBP binding loops; other site 158190004777 ABC-ATPase subunit interface; other site 158190004778 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190004779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004780 dimer interface [polypeptide binding]; other site 158190004781 conserved gate region; other site 158190004782 putative PBP binding loops; other site 158190004783 ABC-ATPase subunit interface; other site 158190004784 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190004785 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190004786 Sensory domain found in PocR; Region: PocR; pfam10114 158190004787 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 158190004788 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190004789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190004790 Phosphotransferase enzyme family; Region: APH; pfam01636 158190004791 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190004792 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190004793 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190004794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158190004795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004796 putative PBP binding loops; other site 158190004797 ABC-ATPase subunit interface; other site 158190004798 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190004799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004800 dimer interface [polypeptide binding]; other site 158190004801 conserved gate region; other site 158190004802 putative PBP binding loops; other site 158190004803 ABC-ATPase subunit interface; other site 158190004804 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 158190004805 dimerization interface [polypeptide binding]; other site 158190004806 putative active cleft [active] 158190004807 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158190004808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190004809 DNA-binding site [nucleotide binding]; DNA binding site 158190004810 FCD domain; Region: FCD; pfam07729 158190004811 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158190004812 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158190004813 inhibitor site; inhibition site 158190004814 active site 158190004815 dimer interface [polypeptide binding]; other site 158190004816 catalytic residue [active] 158190004817 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 158190004818 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158190004819 Walker A/P-loop; other site 158190004820 ATP binding site [chemical binding]; other site 158190004821 Q-loop/lid; other site 158190004822 ABC transporter signature motif; other site 158190004823 Walker B; other site 158190004824 D-loop; other site 158190004825 H-loop/switch region; other site 158190004826 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 158190004827 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 158190004828 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158190004829 Walker A/P-loop; other site 158190004830 ATP binding site [chemical binding]; other site 158190004831 Q-loop/lid; other site 158190004832 ABC transporter signature motif; other site 158190004833 Walker B; other site 158190004834 D-loop; other site 158190004835 H-loop/switch region; other site 158190004836 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 158190004837 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 158190004838 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 158190004839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004840 dimer interface [polypeptide binding]; other site 158190004841 conserved gate region; other site 158190004842 putative PBP binding loops; other site 158190004843 ABC-ATPase subunit interface; other site 158190004844 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158190004845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004846 dimer interface [polypeptide binding]; other site 158190004847 conserved gate region; other site 158190004848 putative PBP binding loops; other site 158190004849 ABC-ATPase subunit interface; other site 158190004850 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 158190004851 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 158190004852 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 158190004853 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 158190004854 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 158190004855 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158190004856 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 158190004857 nucleotide binding site [chemical binding]; other site 158190004858 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190004859 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190004860 TM-ABC transporter signature motif; other site 158190004861 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190004862 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190004863 TM-ABC transporter signature motif; other site 158190004864 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190004865 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190004866 Walker A/P-loop; other site 158190004867 ATP binding site [chemical binding]; other site 158190004868 Q-loop/lid; other site 158190004869 ABC transporter signature motif; other site 158190004870 Walker B; other site 158190004871 D-loop; other site 158190004872 H-loop/switch region; other site 158190004873 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190004874 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 158190004875 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190004876 ligand binding site [chemical binding]; other site 158190004877 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 158190004878 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 158190004879 intersubunit interface [polypeptide binding]; other site 158190004880 active site 158190004881 Zn2+ binding site [ion binding]; other site 158190004882 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158190004883 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158190004884 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158190004885 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190004886 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190004887 DNA binding site [nucleotide binding] 158190004888 domain linker motif; other site 158190004889 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190004890 dimerization interface [polypeptide binding]; other site 158190004891 ligand binding site [chemical binding]; other site 158190004892 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 158190004893 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190004894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004895 dimer interface [polypeptide binding]; other site 158190004896 conserved gate region; other site 158190004897 putative PBP binding loops; other site 158190004898 ABC-ATPase subunit interface; other site 158190004899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004900 dimer interface [polypeptide binding]; other site 158190004901 conserved gate region; other site 158190004902 ABC-ATPase subunit interface; other site 158190004903 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190004904 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190004905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158190004906 PAS domain; Region: PAS_9; pfam13426 158190004907 putative active site [active] 158190004908 heme pocket [chemical binding]; other site 158190004909 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190004910 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190004911 metal binding site [ion binding]; metal-binding site 158190004912 active site 158190004913 I-site; other site 158190004914 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 158190004915 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 158190004916 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 158190004917 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190004918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190004919 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190004920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004921 dimer interface [polypeptide binding]; other site 158190004922 conserved gate region; other site 158190004923 putative PBP binding loops; other site 158190004924 ABC-ATPase subunit interface; other site 158190004925 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190004926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004927 dimer interface [polypeptide binding]; other site 158190004928 conserved gate region; other site 158190004929 putative PBP binding loops; other site 158190004930 ABC-ATPase subunit interface; other site 158190004931 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 158190004932 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 158190004933 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 158190004934 active site 158190004935 catalytic site [active] 158190004936 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190004937 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190004938 DNA binding site [nucleotide binding] 158190004939 domain linker motif; other site 158190004940 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190004941 dimerization interface [polypeptide binding]; other site 158190004942 ligand binding site [chemical binding]; other site 158190004943 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190004944 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158190004945 Metal-binding active site; metal-binding site 158190004946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190004947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004948 dimer interface [polypeptide binding]; other site 158190004949 conserved gate region; other site 158190004950 putative PBP binding loops; other site 158190004951 ABC-ATPase subunit interface; other site 158190004952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190004953 dimer interface [polypeptide binding]; other site 158190004954 conserved gate region; other site 158190004955 putative PBP binding loops; other site 158190004956 ABC-ATPase subunit interface; other site 158190004957 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190004958 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190004959 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190004960 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190004961 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190004962 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 158190004963 Transcriptional regulators [Transcription]; Region: MarR; COG1846 158190004964 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190004965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158190004966 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158190004967 Cupin domain; Region: Cupin_2; pfam07883 158190004968 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 158190004969 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 158190004970 putative active site [active] 158190004971 metal binding site [ion binding]; metal-binding site 158190004972 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 158190004973 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 158190004974 PYR/PP interface [polypeptide binding]; other site 158190004975 dimer interface [polypeptide binding]; other site 158190004976 TPP binding site [chemical binding]; other site 158190004977 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 158190004978 TPP-binding site; other site 158190004979 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158190004980 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 158190004981 active site 158190004982 nucleotide binding site [chemical binding]; other site 158190004983 HIGH motif; other site 158190004984 KMSKS motif; other site 158190004985 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 158190004986 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 158190004987 tetramer interface [polypeptide binding]; other site 158190004988 active site 158190004989 Mg2+/Mn2+ binding site [ion binding]; other site 158190004990 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 158190004991 active site 158190004992 metal-binding site 158190004993 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 158190004994 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 158190004995 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 158190004996 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 158190004997 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 158190004998 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 158190004999 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 158190005000 O-Antigen ligase; Region: Wzy_C; pfam04932 158190005001 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 158190005002 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190005003 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 158190005004 putative ADP-binding pocket [chemical binding]; other site 158190005005 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158190005006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190005007 NAD(P) binding site [chemical binding]; other site 158190005008 active site 158190005009 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 158190005010 substrate binding site; other site 158190005011 dimer interface; other site 158190005012 LicD family; Region: LicD; cl01378 158190005013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158190005014 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 158190005015 putative NAD(P) binding site [chemical binding]; other site 158190005016 active site 158190005017 putative substrate binding site [chemical binding]; other site 158190005018 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 158190005019 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 158190005020 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 158190005021 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 158190005022 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 158190005023 putative active site [active] 158190005024 putative metal binding site [ion binding]; other site 158190005025 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 158190005026 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 158190005027 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 158190005028 active site 158190005029 metal-binding site 158190005030 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 158190005031 trimer interface [polypeptide binding]; other site 158190005032 active site 158190005033 substrate binding site [chemical binding]; other site 158190005034 CoA binding site [chemical binding]; other site 158190005035 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 158190005036 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 158190005037 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 158190005038 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 158190005039 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190005040 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 158190005041 putative ADP-binding pocket [chemical binding]; other site 158190005042 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190005043 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 158190005044 putative ADP-binding pocket [chemical binding]; other site 158190005045 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 158190005046 putative ADP-binding pocket [chemical binding]; other site 158190005047 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190005048 Bacterial sugar transferase; Region: Bac_transf; pfam02397 158190005049 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 158190005050 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 158190005051 inhibitor-cofactor binding pocket; inhibition site 158190005052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190005053 catalytic residue [active] 158190005054 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 158190005055 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 158190005056 NAD(P) binding site [chemical binding]; other site 158190005057 homodimer interface [polypeptide binding]; other site 158190005058 substrate binding site [chemical binding]; other site 158190005059 active site 158190005060 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 158190005061 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 158190005062 putative active site [active] 158190005063 metal binding site [ion binding]; metal-binding site 158190005064 Divergent AAA domain; Region: AAA_4; pfam04326 158190005065 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 158190005066 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 158190005067 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 158190005068 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190005069 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190005070 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190005071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005072 dimer interface [polypeptide binding]; other site 158190005073 conserved gate region; other site 158190005074 ABC-ATPase subunit interface; other site 158190005075 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190005076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005077 dimer interface [polypeptide binding]; other site 158190005078 conserved gate region; other site 158190005079 ABC-ATPase subunit interface; other site 158190005080 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 158190005081 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190005082 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190005083 nucleotide binding site [chemical binding]; other site 158190005084 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158190005085 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158190005086 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158190005087 putative active site [active] 158190005088 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158190005089 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158190005090 trimer interface [polypeptide binding]; other site 158190005091 substrate binding site [chemical binding]; other site 158190005092 Mn binding site [ion binding]; other site 158190005093 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 158190005094 active site 158190005095 catalytic residues [active] 158190005096 AAA domain; Region: AAA_14; pfam13173 158190005097 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 158190005098 putative alpha-glucosidase; Provisional; Region: PRK10658 158190005099 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 158190005100 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 158190005101 active site 158190005102 homotrimer interface [polypeptide binding]; other site 158190005103 catalytic site [active] 158190005104 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 158190005105 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190005106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005107 dimer interface [polypeptide binding]; other site 158190005108 conserved gate region; other site 158190005109 putative PBP binding loops; other site 158190005110 ABC-ATPase subunit interface; other site 158190005111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005112 dimer interface [polypeptide binding]; other site 158190005113 conserved gate region; other site 158190005114 putative PBP binding loops; other site 158190005115 ABC-ATPase subunit interface; other site 158190005116 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190005117 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190005118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190005119 DNA binding site [nucleotide binding] 158190005120 domain linker motif; other site 158190005121 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158190005122 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190005123 ligand binding site [chemical binding]; other site 158190005124 Fic family protein [Function unknown]; Region: COG3177 158190005125 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 158190005126 Fic/DOC family; Region: Fic; pfam02661 158190005127 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190005128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190005129 non-specific DNA binding site [nucleotide binding]; other site 158190005130 salt bridge; other site 158190005131 sequence-specific DNA binding site [nucleotide binding]; other site 158190005132 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 158190005133 AAA domain; Region: AAA_21; pfam13304 158190005134 RloB-like protein; Region: RloB; pfam13707 158190005135 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 158190005136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190005137 binding surface 158190005138 TPR motif; other site 158190005139 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 158190005140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190005141 TPR repeat; Region: TPR_11; pfam13414 158190005142 binding surface 158190005143 TPR motif; other site 158190005144 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 158190005145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190005146 TPR motif; other site 158190005147 binding surface 158190005148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190005149 binding surface 158190005150 TPR motif; other site 158190005151 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190005152 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190005153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190005154 TPR motif; other site 158190005155 binding surface 158190005156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 158190005157 Histidine kinase; Region: His_kinase; pfam06580 158190005158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190005159 Mg2+ binding site [ion binding]; other site 158190005160 G-X-G motif; other site 158190005161 Response regulator receiver domain; Region: Response_reg; pfam00072 158190005162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190005163 active site 158190005164 phosphorylation site [posttranslational modification] 158190005165 intermolecular recognition site; other site 158190005166 dimerization interface [polypeptide binding]; other site 158190005167 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190005168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190005169 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190005170 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190005171 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190005172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005173 dimer interface [polypeptide binding]; other site 158190005174 conserved gate region; other site 158190005175 putative PBP binding loops; other site 158190005176 ABC-ATPase subunit interface; other site 158190005177 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190005178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005179 dimer interface [polypeptide binding]; other site 158190005180 conserved gate region; other site 158190005181 putative PBP binding loops; other site 158190005182 ABC-ATPase subunit interface; other site 158190005183 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 158190005184 Transposase IS200 like; Region: Y1_Tnp; cl00848 158190005185 Homeodomain-like domain; Region: HTH_23; pfam13384 158190005186 DNA protecting protein DprA; Region: dprA; TIGR00732 158190005187 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 158190005188 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 158190005189 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 158190005190 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 158190005191 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 158190005192 AAA domain; Region: AAA_14; pfam13173 158190005193 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 158190005194 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 158190005195 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 158190005196 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 158190005197 Preprotein binding site; other site 158190005198 SecA binding site; other site 158190005199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 158190005200 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 158190005201 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 158190005202 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 158190005203 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 158190005204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 158190005205 Transposase; Region: HTH_Tnp_1; cl17663 158190005206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 158190005207 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 158190005208 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 158190005209 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 158190005210 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 158190005211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 158190005212 Transposase; Region: HTH_Tnp_1; cl17663 158190005213 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 158190005214 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 158190005215 active site 158190005216 homodimer interface [polypeptide binding]; other site 158190005217 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 158190005218 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 158190005219 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 158190005220 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 158190005221 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 158190005222 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 158190005223 trimer interface [polypeptide binding]; other site 158190005224 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 158190005225 CoA binding site [chemical binding]; other site 158190005226 active site 158190005227 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 158190005228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158190005229 active site 158190005230 DNA binding site [nucleotide binding] 158190005231 Int/Topo IB signature motif; other site 158190005232 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158190005233 active site 158190005234 DNA binding site [nucleotide binding] 158190005235 Int/Topo IB signature motif; other site 158190005236 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 158190005237 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 158190005238 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 158190005239 active site 158190005240 DNA binding site [nucleotide binding] 158190005241 Int/Topo IB signature motif; other site 158190005242 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158190005243 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 158190005244 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 158190005245 NADP binding site [chemical binding]; other site 158190005246 active site 158190005247 putative substrate binding site [chemical binding]; other site 158190005248 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 158190005249 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 158190005250 NADP-binding site; other site 158190005251 homotetramer interface [polypeptide binding]; other site 158190005252 substrate binding site [chemical binding]; other site 158190005253 homodimer interface [polypeptide binding]; other site 158190005254 active site 158190005255 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 158190005256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190005257 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 158190005258 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158190005259 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 158190005260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190005261 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158190005262 Coenzyme A binding pocket [chemical binding]; other site 158190005263 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 158190005264 Bacterial sugar transferase; Region: Bac_transf; pfam02397 158190005265 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 158190005266 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 158190005267 inhibitor-cofactor binding pocket; inhibition site 158190005268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190005269 catalytic residue [active] 158190005270 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190005271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190005272 non-specific DNA binding site [nucleotide binding]; other site 158190005273 salt bridge; other site 158190005274 sequence-specific DNA binding site [nucleotide binding]; other site 158190005275 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 158190005276 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 158190005277 NAD(P) binding site [chemical binding]; other site 158190005278 homodimer interface [polypeptide binding]; other site 158190005279 substrate binding site [chemical binding]; other site 158190005280 active site 158190005281 Transcription antiterminator [Transcription]; Region: NusG; COG0250 158190005282 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 158190005283 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 158190005284 heterodimer interface [polypeptide binding]; other site 158190005285 homodimer interface [polypeptide binding]; other site 158190005286 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 158190005287 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 158190005288 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 158190005289 shikimate binding site; other site 158190005290 NAD(P) binding site [chemical binding]; other site 158190005291 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 158190005292 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 158190005293 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158190005294 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 158190005295 Predicted ATPases [General function prediction only]; Region: COG1106 158190005296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190005297 ABC transporter signature motif; other site 158190005298 Walker B; other site 158190005299 D-loop; other site 158190005300 H-loop/switch region; other site 158190005301 RloB-like protein; Region: RloB; pfam13707 158190005302 Cupin domain; Region: Cupin_2; pfam07883 158190005303 AAA ATPase domain; Region: AAA_16; pfam13191 158190005304 Archaeal ATPase; Region: Arch_ATPase; pfam01637 158190005305 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 158190005306 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 158190005307 putative FMN binding site [chemical binding]; other site 158190005308 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 158190005309 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 158190005310 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 158190005311 active site 158190005312 catalytic site [active] 158190005313 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190005314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005315 dimer interface [polypeptide binding]; other site 158190005316 conserved gate region; other site 158190005317 putative PBP binding loops; other site 158190005318 ABC-ATPase subunit interface; other site 158190005319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005320 dimer interface [polypeptide binding]; other site 158190005321 conserved gate region; other site 158190005322 putative PBP binding loops; other site 158190005323 ABC-ATPase subunit interface; other site 158190005324 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158190005325 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190005326 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190005327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190005328 DNA binding site [nucleotide binding] 158190005329 domain linker motif; other site 158190005330 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190005331 ligand binding site [chemical binding]; other site 158190005332 dimerization interface [polypeptide binding]; other site 158190005333 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 158190005334 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190005335 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190005336 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190005337 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158190005338 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 158190005339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190005340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190005341 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190005342 Probable beta-xylosidase; Provisional; Region: PLN03080 158190005343 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 158190005344 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 158190005345 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190005346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005347 dimer interface [polypeptide binding]; other site 158190005348 conserved gate region; other site 158190005349 putative PBP binding loops; other site 158190005350 ABC-ATPase subunit interface; other site 158190005351 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190005352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005353 dimer interface [polypeptide binding]; other site 158190005354 conserved gate region; other site 158190005355 putative PBP binding loops; other site 158190005356 ABC-ATPase subunit interface; other site 158190005357 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 158190005358 DctM-like transporters; Region: DctM; pfam06808 158190005359 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 158190005360 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 158190005361 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720 158190005362 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 158190005363 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158190005364 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158190005365 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158190005366 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 158190005367 dimer interface [polypeptide binding]; other site 158190005368 active site 158190005369 catalytic residue [active] 158190005370 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 158190005371 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158190005372 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158190005373 ligand binding site [chemical binding]; other site 158190005374 flexible hinge region; other site 158190005375 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 158190005376 non-specific DNA interactions [nucleotide binding]; other site 158190005377 DNA binding site [nucleotide binding] 158190005378 sequence specific DNA binding site [nucleotide binding]; other site 158190005379 putative cAMP binding site [chemical binding]; other site 158190005380 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 158190005381 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 158190005382 metal binding site [ion binding]; metal-binding site 158190005383 dimer interface [polypeptide binding]; other site 158190005384 Predicted membrane protein [Function unknown]; Region: COG1288 158190005385 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 158190005386 acetolactate synthase; Reviewed; Region: PRK08322 158190005387 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 158190005388 PYR/PP interface [polypeptide binding]; other site 158190005389 dimer interface [polypeptide binding]; other site 158190005390 TPP binding site [chemical binding]; other site 158190005391 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 158190005392 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 158190005393 TPP-binding site [chemical binding]; other site 158190005394 dimer interface [polypeptide binding]; other site 158190005395 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 158190005396 putative FMN binding site [chemical binding]; other site 158190005397 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190005398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190005399 metal binding site [ion binding]; metal-binding site 158190005400 active site 158190005401 I-site; other site 158190005402 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 158190005403 galactarate dehydratase; Region: galactar-dH20; TIGR03248 158190005404 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 158190005405 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 158190005406 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 158190005407 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158190005408 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158190005409 inhibitor site; inhibition site 158190005410 active site 158190005411 dimer interface [polypeptide binding]; other site 158190005412 catalytic residue [active] 158190005413 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 158190005414 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 158190005415 active site 158190005416 tetramer interface [polypeptide binding]; other site 158190005417 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 158190005418 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 158190005419 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 158190005420 Transcriptional regulator [Transcription]; Region: IclR; COG1414 158190005421 Bacterial transcriptional regulator; Region: IclR; pfam01614 158190005422 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190005423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190005424 non-specific DNA binding site [nucleotide binding]; other site 158190005425 salt bridge; other site 158190005426 sequence-specific DNA binding site [nucleotide binding]; other site 158190005427 HipA N-terminal domain; Region: Couple_hipA; pfam13657 158190005428 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 158190005429 HipA-like N-terminal domain; Region: HipA_N; pfam07805 158190005430 HipA-like C-terminal domain; Region: HipA_C; pfam07804 158190005431 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 158190005432 dihydroxyacetone kinase; Provisional; Region: PRK14479 158190005433 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 158190005434 DAK2 domain; Region: Dak2; pfam02734 158190005435 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 158190005436 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 158190005437 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 158190005438 Walker A/P-loop; other site 158190005439 ATP binding site [chemical binding]; other site 158190005440 Q-loop/lid; other site 158190005441 ABC transporter signature motif; other site 158190005442 Walker B; other site 158190005443 D-loop; other site 158190005444 H-loop/switch region; other site 158190005445 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 158190005446 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 158190005447 Walker A/P-loop; other site 158190005448 ATP binding site [chemical binding]; other site 158190005449 Q-loop/lid; other site 158190005450 ABC transporter signature motif; other site 158190005451 Walker B; other site 158190005452 D-loop; other site 158190005453 H-loop/switch region; other site 158190005454 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 158190005455 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190005456 TM-ABC transporter signature motif; other site 158190005457 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190005458 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 158190005459 TM-ABC transporter signature motif; other site 158190005460 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 158190005461 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190005462 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158190005463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190005464 DNA-binding site [nucleotide binding]; DNA binding site 158190005465 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 158190005466 DAK2 domain; Region: Dak2; pfam02734 158190005467 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 158190005468 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 158190005469 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 158190005470 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 158190005471 Walker A/P-loop; other site 158190005472 ATP binding site [chemical binding]; other site 158190005473 Q-loop/lid; other site 158190005474 ABC transporter signature motif; other site 158190005475 Walker B; other site 158190005476 D-loop; other site 158190005477 H-loop/switch region; other site 158190005478 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 158190005479 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 158190005480 Walker A/P-loop; other site 158190005481 ATP binding site [chemical binding]; other site 158190005482 Q-loop/lid; other site 158190005483 ABC transporter signature motif; other site 158190005484 Walker B; other site 158190005485 D-loop; other site 158190005486 H-loop/switch region; other site 158190005487 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 158190005488 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 158190005489 TM-ABC transporter signature motif; other site 158190005490 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190005491 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 158190005492 TM-ABC transporter signature motif; other site 158190005493 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 158190005494 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190005495 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 158190005496 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158190005497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190005498 DNA-binding site [nucleotide binding]; DNA binding site 158190005499 FCD domain; Region: FCD; pfam07729 158190005500 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158190005501 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 158190005502 substrate binding site [chemical binding]; other site 158190005503 dimer interface [polypeptide binding]; other site 158190005504 ATP binding site [chemical binding]; other site 158190005505 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190005506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190005507 nucleotide binding site [chemical binding]; other site 158190005508 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 158190005509 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158190005510 dimer interface [polypeptide binding]; other site 158190005511 active site 158190005512 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190005513 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190005514 Walker A/P-loop; other site 158190005515 ATP binding site [chemical binding]; other site 158190005516 Q-loop/lid; other site 158190005517 ABC transporter signature motif; other site 158190005518 Walker B; other site 158190005519 D-loop; other site 158190005520 H-loop/switch region; other site 158190005521 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190005522 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190005523 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190005524 TM-ABC transporter signature motif; other site 158190005525 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158190005526 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158190005527 ligand binding site [chemical binding]; other site 158190005528 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190005529 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190005530 nucleotide binding site [chemical binding]; other site 158190005531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 158190005532 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 158190005533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 158190005534 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 158190005535 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158190005536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190005537 DNA-binding site [nucleotide binding]; DNA binding site 158190005538 FCD domain; Region: FCD; pfam07729 158190005539 peptidase; Reviewed; Region: PRK13004 158190005540 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 158190005541 putative metal binding site [ion binding]; other site 158190005542 putative dimer interface [polypeptide binding]; other site 158190005543 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 158190005544 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 158190005545 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190005546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190005547 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190005548 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158190005549 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 158190005550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005551 dimer interface [polypeptide binding]; other site 158190005552 conserved gate region; other site 158190005553 putative PBP binding loops; other site 158190005554 ABC-ATPase subunit interface; other site 158190005555 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190005556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005557 dimer interface [polypeptide binding]; other site 158190005558 conserved gate region; other site 158190005559 putative PBP binding loops; other site 158190005560 ABC-ATPase subunit interface; other site 158190005561 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158190005562 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 158190005563 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 158190005564 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 158190005565 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 158190005566 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 158190005567 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 158190005568 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 158190005569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190005570 S-adenosylmethionine binding site [chemical binding]; other site 158190005571 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 158190005572 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 158190005573 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 158190005574 Protein of unknown function (DUF523); Region: DUF523; pfam04463 158190005575 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 158190005576 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190005577 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190005578 TM-ABC transporter signature motif; other site 158190005579 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190005580 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190005581 TM-ABC transporter signature motif; other site 158190005582 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190005583 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190005584 Walker A/P-loop; other site 158190005585 ATP binding site [chemical binding]; other site 158190005586 Q-loop/lid; other site 158190005587 ABC transporter signature motif; other site 158190005588 Walker B; other site 158190005589 D-loop; other site 158190005590 H-loop/switch region; other site 158190005591 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190005592 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190005593 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 158190005594 putative ligand binding site [chemical binding]; other site 158190005595 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 158190005596 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158190005597 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190005598 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 158190005599 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158190005600 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 158190005601 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 158190005602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190005603 DNA-binding site [nucleotide binding]; DNA binding site 158190005604 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 158190005605 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158190005606 asparagine synthetase B; Provisional; Region: asnB; PRK09431 158190005607 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 158190005608 active site 158190005609 dimer interface [polypeptide binding]; other site 158190005610 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 158190005611 Ligand Binding Site [chemical binding]; other site 158190005612 Molecular Tunnel; other site 158190005613 acetylornithine aminotransferase; Provisional; Region: PRK02627 158190005614 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 158190005615 inhibitor-cofactor binding pocket; inhibition site 158190005616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190005617 catalytic residue [active] 158190005618 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 158190005619 feedback inhibition sensing region; other site 158190005620 homohexameric interface [polypeptide binding]; other site 158190005621 nucleotide binding site [chemical binding]; other site 158190005622 N-acetyl-L-glutamate binding site [chemical binding]; other site 158190005623 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 158190005624 heterotetramer interface [polypeptide binding]; other site 158190005625 active site pocket [active] 158190005626 cleavage site 158190005627 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 158190005628 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 158190005629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158190005630 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 158190005631 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190005632 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190005633 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190005634 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190005635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190005636 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190005637 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190005638 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190005639 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190005640 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 158190005641 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190005642 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190005643 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 158190005644 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158190005645 phosphate binding site [ion binding]; other site 158190005646 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 158190005647 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158190005648 Quinolinate synthetase A protein; Region: NadA; cl00420 158190005649 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 158190005650 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190005651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005652 dimer interface [polypeptide binding]; other site 158190005653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158190005654 ABC-ATPase subunit interface; other site 158190005655 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190005656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005657 dimer interface [polypeptide binding]; other site 158190005658 conserved gate region; other site 158190005659 ABC-ATPase subunit interface; other site 158190005660 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190005661 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 158190005662 inhibitor binding site; inhibition site 158190005663 active site 158190005664 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 158190005665 PAS domain S-box; Region: sensory_box; TIGR00229 158190005666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158190005667 putative active site [active] 158190005668 heme pocket [chemical binding]; other site 158190005669 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190005670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190005671 metal binding site [ion binding]; metal-binding site 158190005672 active site 158190005673 I-site; other site 158190005674 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 158190005675 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190005676 Zn2+ binding site [ion binding]; other site 158190005677 Mg2+ binding site [ion binding]; other site 158190005678 PAS domain S-box; Region: sensory_box; TIGR00229 158190005679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 158190005680 putative active site [active] 158190005681 heme pocket [chemical binding]; other site 158190005682 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190005683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190005684 metal binding site [ion binding]; metal-binding site 158190005685 active site 158190005686 I-site; other site 158190005687 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 158190005688 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 158190005689 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 158190005690 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 158190005691 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 158190005692 putative active site [active] 158190005693 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190005694 4Fe-4S binding domain; Region: Fer4; pfam00037 158190005695 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 158190005696 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 158190005697 active site 158190005698 FMN binding site [chemical binding]; other site 158190005699 substrate binding site [chemical binding]; other site 158190005700 3Fe-4S cluster binding site [ion binding]; other site 158190005701 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 158190005702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 158190005703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158190005704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158190005705 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 158190005706 putative subunit interface; other site 158190005707 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 158190005708 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 158190005709 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 158190005710 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 158190005711 ANTAR domain; Region: ANTAR; pfam03861 158190005712 CTP synthetase; Validated; Region: pyrG; PRK05380 158190005713 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 158190005714 Catalytic site [active] 158190005715 active site 158190005716 UTP binding site [chemical binding]; other site 158190005717 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 158190005718 active site 158190005719 putative oxyanion hole; other site 158190005720 catalytic triad [active] 158190005721 Predicted transcriptional regulators [Transcription]; Region: COG1695 158190005722 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 158190005723 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 158190005724 putative trimer interface [polypeptide binding]; other site 158190005725 putative CoA binding site [chemical binding]; other site 158190005726 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158190005727 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158190005728 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 158190005729 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158190005730 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 158190005731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190005732 Walker A/P-loop; other site 158190005733 ATP binding site [chemical binding]; other site 158190005734 Q-loop/lid; other site 158190005735 ABC transporter signature motif; other site 158190005736 Walker B; other site 158190005737 D-loop; other site 158190005738 H-loop/switch region; other site 158190005739 TOBE domain; Region: TOBE_2; pfam08402 158190005740 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158190005741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005742 dimer interface [polypeptide binding]; other site 158190005743 conserved gate region; other site 158190005744 putative PBP binding loops; other site 158190005745 ABC-ATPase subunit interface; other site 158190005746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005747 dimer interface [polypeptide binding]; other site 158190005748 conserved gate region; other site 158190005749 putative PBP binding loops; other site 158190005750 ABC-ATPase subunit interface; other site 158190005751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190005752 dimerization interface [polypeptide binding]; other site 158190005753 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 158190005754 Histidine kinase; Region: His_kinase; pfam06580 158190005755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190005756 ATP binding site [chemical binding]; other site 158190005757 Mg2+ binding site [ion binding]; other site 158190005758 G-X-G motif; other site 158190005759 Response regulator receiver domain; Region: Response_reg; pfam00072 158190005760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190005761 active site 158190005762 phosphorylation site [posttranslational modification] 158190005763 intermolecular recognition site; other site 158190005764 dimerization interface [polypeptide binding]; other site 158190005765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190005766 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190005767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190005768 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 158190005769 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 158190005770 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 158190005771 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190005772 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190005773 DNA binding site [nucleotide binding] 158190005774 domain linker motif; other site 158190005775 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190005776 dimerization interface [polypeptide binding]; other site 158190005777 ligand binding site [chemical binding]; other site 158190005778 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 158190005779 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190005780 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190005781 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190005782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005783 dimer interface [polypeptide binding]; other site 158190005784 conserved gate region; other site 158190005785 putative PBP binding loops; other site 158190005786 ABC-ATPase subunit interface; other site 158190005787 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190005788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005789 dimer interface [polypeptide binding]; other site 158190005790 conserved gate region; other site 158190005791 putative PBP binding loops; other site 158190005792 ABC-ATPase subunit interface; other site 158190005793 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 158190005794 putative catalytic site [active] 158190005795 putative metal binding site [ion binding]; other site 158190005796 putative phosphate binding site [ion binding]; other site 158190005797 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 158190005798 active site 158190005799 catalytic triad [active] 158190005800 oxyanion hole [active] 158190005801 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 158190005802 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 158190005803 active site 158190005804 catalytic site [active] 158190005805 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190005806 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 158190005807 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190005808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005809 dimer interface [polypeptide binding]; other site 158190005810 conserved gate region; other site 158190005811 putative PBP binding loops; other site 158190005812 ABC-ATPase subunit interface; other site 158190005813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005814 dimer interface [polypeptide binding]; other site 158190005815 conserved gate region; other site 158190005816 putative PBP binding loops; other site 158190005817 ABC-ATPase subunit interface; other site 158190005818 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190005819 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190005820 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 158190005821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158190005822 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158190005823 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 158190005824 active site residue [active] 158190005825 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 158190005826 CPxP motif; other site 158190005827 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 158190005828 SlyX; Region: SlyX; pfam04102 158190005829 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 158190005830 DNA-binding interface [nucleotide binding]; DNA binding site 158190005831 hypothetical protein; Provisional; Region: PHA03007 158190005832 WYL domain; Region: WYL; pfam13280 158190005833 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 158190005834 Rubredoxin; Region: Rubredoxin; pfam00301 158190005835 iron binding site [ion binding]; other site 158190005836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190005837 active site 158190005838 phosphorylation site [posttranslational modification] 158190005839 intermolecular recognition site; other site 158190005840 dimerization interface [polypeptide binding]; other site 158190005841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190005842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190005843 metal binding site [ion binding]; metal-binding site 158190005844 active site 158190005845 I-site; other site 158190005846 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158190005847 PAS fold; Region: PAS_3; pfam08447 158190005848 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 158190005849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190005850 Coenzyme A binding pocket [chemical binding]; other site 158190005851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190005852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190005853 putative substrate translocation pore; other site 158190005854 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 158190005855 FMN binding site [chemical binding]; other site 158190005856 dimer interface [polypeptide binding]; other site 158190005857 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 158190005858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190005859 active site 158190005860 phosphorylation site [posttranslational modification] 158190005861 intermolecular recognition site; other site 158190005862 dimerization interface [polypeptide binding]; other site 158190005863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190005864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190005865 Cache domain; Region: Cache_1; pfam02743 158190005866 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 158190005867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190005868 dimerization interface [polypeptide binding]; other site 158190005869 Histidine kinase; Region: His_kinase; pfam06580 158190005870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190005871 ATP binding site [chemical binding]; other site 158190005872 Mg2+ binding site [ion binding]; other site 158190005873 G-X-G motif; other site 158190005874 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158190005875 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190005876 ligand binding site [chemical binding]; other site 158190005877 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190005878 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190005879 TM-ABC transporter signature motif; other site 158190005880 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190005881 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 158190005882 Walker A/P-loop; other site 158190005883 ATP binding site [chemical binding]; other site 158190005884 Q-loop/lid; other site 158190005885 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190005886 ABC transporter signature motif; other site 158190005887 Walker B; other site 158190005888 D-loop; other site 158190005889 H-loop/switch region; other site 158190005890 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190005891 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 158190005892 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 158190005893 ligand binding site [chemical binding]; other site 158190005894 calcium binding site [ion binding]; other site 158190005895 putative pectinesterase; Region: PLN02432; cl01911 158190005896 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 158190005897 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 158190005898 dimer interface [polypeptide binding]; other site 158190005899 PYR/PP interface [polypeptide binding]; other site 158190005900 TPP binding site [chemical binding]; other site 158190005901 substrate binding site [chemical binding]; other site 158190005902 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 158190005903 Domain of unknown function; Region: EKR; pfam10371 158190005904 4Fe-4S binding domain; Region: Fer4_6; pfam12837 158190005905 4Fe-4S binding domain; Region: Fer4; pfam00037 158190005906 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 158190005907 TPP-binding site [chemical binding]; other site 158190005908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190005909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190005910 putative substrate translocation pore; other site 158190005911 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 158190005912 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 158190005913 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 158190005914 active site 158190005915 dimer interface [polypeptide binding]; other site 158190005916 effector binding site; other site 158190005917 TSCPD domain; Region: TSCPD; pfam12637 158190005918 glutamate dehydrogenase; Provisional; Region: PRK09414 158190005919 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 158190005920 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 158190005921 NAD(P) binding site [chemical binding]; other site 158190005922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190005923 active site 158190005924 phosphorylation site [posttranslational modification] 158190005925 intermolecular recognition site; other site 158190005926 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 158190005927 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 158190005928 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158190005929 active site 158190005930 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 158190005931 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 158190005932 CAP-like domain; other site 158190005933 active site 158190005934 primary dimer interface [polypeptide binding]; other site 158190005935 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 158190005936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 158190005937 ATP binding site [chemical binding]; other site 158190005938 Mg2+ binding site [ion binding]; other site 158190005939 G-X-G motif; other site 158190005940 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 158190005941 anchoring element; other site 158190005942 dimer interface [polypeptide binding]; other site 158190005943 ATP binding site [chemical binding]; other site 158190005944 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 158190005945 active site 158190005946 putative metal-binding site [ion binding]; other site 158190005947 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 158190005948 YhhN-like protein; Region: YhhN; pfam07947 158190005949 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 158190005950 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 158190005951 oligomer interface [polypeptide binding]; other site 158190005952 metal binding site [ion binding]; metal-binding site 158190005953 metal binding site [ion binding]; metal-binding site 158190005954 Cl binding site [ion binding]; other site 158190005955 aspartate ring; other site 158190005956 putative hydrophobic gate; other site 158190005957 periplasmic entrance; other site 158190005958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190005959 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158190005960 Coenzyme A binding pocket [chemical binding]; other site 158190005961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190005962 Coenzyme A binding pocket [chemical binding]; other site 158190005963 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 158190005964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190005965 Coenzyme A binding pocket [chemical binding]; other site 158190005966 Domain of unknown function DUF21; Region: DUF21; pfam01595 158190005967 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 158190005968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 158190005969 Transporter associated domain; Region: CorC_HlyC; smart01091 158190005970 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 158190005971 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 158190005972 HIGH motif; other site 158190005973 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 158190005974 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158190005975 active site 158190005976 KMSKS motif; other site 158190005977 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 158190005978 tRNA binding surface [nucleotide binding]; other site 158190005979 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 158190005980 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158190005981 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 158190005982 active site 158190005983 catalytic site [active] 158190005984 metal binding site [ion binding]; metal-binding site 158190005985 dimer interface [polypeptide binding]; other site 158190005986 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 158190005987 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 158190005988 Walker A/P-loop; other site 158190005989 ATP binding site [chemical binding]; other site 158190005990 Q-loop/lid; other site 158190005991 ABC transporter signature motif; other site 158190005992 Walker B; other site 158190005993 D-loop; other site 158190005994 H-loop/switch region; other site 158190005995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190005996 dimer interface [polypeptide binding]; other site 158190005997 conserved gate region; other site 158190005998 putative PBP binding loops; other site 158190005999 ABC-ATPase subunit interface; other site 158190006000 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 158190006001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158190006002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190006003 putative PBP binding loops; other site 158190006004 dimer interface [polypeptide binding]; other site 158190006005 ABC-ATPase subunit interface; other site 158190006006 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 158190006007 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190006008 substrate binding pocket [chemical binding]; other site 158190006009 membrane-bound complex binding site; other site 158190006010 hinge residues; other site 158190006011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190006012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190006013 DNA binding site [nucleotide binding] 158190006014 domain linker motif; other site 158190006015 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190006016 dimerization interface [polypeptide binding]; other site 158190006017 ligand binding site [chemical binding]; other site 158190006018 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 158190006019 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 158190006020 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 158190006021 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 158190006022 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 158190006023 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 158190006024 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 158190006025 Prephenate dehydratase; Region: PDT; pfam00800 158190006026 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 158190006027 putative L-Phe binding site [chemical binding]; other site 158190006028 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158190006029 endonuclease III; Region: ENDO3c; smart00478 158190006030 minor groove reading motif; other site 158190006031 helix-hairpin-helix signature motif; other site 158190006032 substrate binding pocket [chemical binding]; other site 158190006033 active site 158190006034 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 158190006035 FAD binding site [chemical binding]; other site 158190006036 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 158190006037 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 158190006038 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 158190006039 substrate binding pocket [chemical binding]; other site 158190006040 dimer interface [polypeptide binding]; other site 158190006041 inhibitor binding site; inhibition site 158190006042 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 158190006043 B12 binding site [chemical binding]; other site 158190006044 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 158190006045 hypothetical protein; Provisional; Region: PRK04334 158190006046 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 158190006047 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190006048 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190006049 Domain of unknown function DUF39; Region: DUF39; pfam01837 158190006050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 158190006051 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 158190006052 putative active site [active] 158190006053 catalytic residue [active] 158190006054 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 158190006055 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 158190006056 active site 158190006057 catalytic site [active] 158190006058 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 158190006059 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 158190006060 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 158190006061 DctM-like transporters; Region: DctM; pfam06808 158190006062 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 158190006063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 158190006064 substrate binding pocket [chemical binding]; other site 158190006065 membrane-bound complex binding site; other site 158190006066 hinge residues; other site 158190006067 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 158190006068 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 158190006069 hinge; other site 158190006070 active site 158190006071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190006072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190006073 DNA binding site [nucleotide binding] 158190006074 domain linker motif; other site 158190006075 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190006076 dimerization interface [polypeptide binding]; other site 158190006077 ligand binding site [chemical binding]; other site 158190006078 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 158190006079 active site 158190006080 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158190006081 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158190006082 ligand binding site [chemical binding]; other site 158190006083 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 158190006084 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 158190006085 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 158190006086 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 158190006087 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 158190006088 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 158190006089 active site 158190006090 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 158190006091 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 158190006092 C-terminal peptidase (prc); Region: prc; TIGR00225 158190006093 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 158190006094 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 158190006095 Catalytic dyad [active] 158190006096 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 158190006097 RNA methyltransferase, RsmE family; Region: TIGR00046 158190006098 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 158190006099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190006100 Walker A motif; other site 158190006101 ATP binding site [chemical binding]; other site 158190006102 Walker B motif; other site 158190006103 arginine finger; other site 158190006104 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 158190006105 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 158190006106 hinge; other site 158190006107 active site 158190006108 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 158190006109 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158190006110 substrate binding site [chemical binding]; other site 158190006111 ATP binding site [chemical binding]; other site 158190006112 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190006113 putative DNA binding site [nucleotide binding]; other site 158190006114 putative Zn2+ binding site [ion binding]; other site 158190006115 S-adenosylmethionine synthetase; Validated; Region: PRK05250 158190006116 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 158190006117 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 158190006118 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 158190006119 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 158190006120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190006121 FeS/SAM binding site; other site 158190006122 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 158190006123 ATP cone domain; Region: ATP-cone; pfam03477 158190006124 Class III ribonucleotide reductase; Region: RNR_III; cd01675 158190006125 effector binding site; other site 158190006126 active site 158190006127 Zn binding site [ion binding]; other site 158190006128 glycine loop; other site 158190006129 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 158190006130 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 158190006131 G-X-X-G motif; other site 158190006132 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 158190006133 RxxxH motif; other site 158190006134 membrane protein insertase; Provisional; Region: PRK01318 158190006135 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 158190006136 Ribonuclease P; Region: Ribonuclease_P; pfam00825 158190006137 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 158190006138 Protein of unknown function (DUF721); Region: DUF721; pfam05258 158190006139 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 158190006140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190006141 Walker A/P-loop; other site 158190006142 ATP binding site [chemical binding]; other site 158190006143 Q-loop/lid; other site 158190006144 ABC transporter signature motif; other site 158190006145 DNA polymerase III subunit beta; Provisional; Region: PRK14940 158190006146 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 158190006147 putative DNA binding surface [nucleotide binding]; other site 158190006148 dimer interface [polypeptide binding]; other site 158190006149 beta-clamp/clamp loader binding surface; other site 158190006150 beta-clamp/translesion DNA polymerase binding surface; other site 158190006151 DnaA N-terminal domain; Region: DnaA_N; pfam11638 158190006152 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 158190006153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190006154 Walker A motif; other site 158190006155 ATP binding site [chemical binding]; other site 158190006156 Walker B motif; other site 158190006157 arginine finger; other site 158190006158 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 158190006159 DnaA box-binding interface [nucleotide binding]; other site 158190006160 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 158190006161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190006162 ATP binding site [chemical binding]; other site 158190006163 Mg2+ binding site [ion binding]; other site 158190006164 G-X-G motif; other site 158190006165 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 158190006166 anchoring element; other site 158190006167 dimer interface [polypeptide binding]; other site 158190006168 ATP binding site [chemical binding]; other site 158190006169 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 158190006170 active site 158190006171 putative metal-binding site [ion binding]; other site 158190006172 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 158190006173 DNA gyrase subunit A; Validated; Region: PRK05560 158190006174 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 158190006175 CAP-like domain; other site 158190006176 active site 158190006177 primary dimer interface [polypeptide binding]; other site 158190006178 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158190006179 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158190006180 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158190006181 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158190006182 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158190006183 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 158190006184 NifU-like domain; Region: NifU; pfam01106 158190006185 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 158190006186 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 158190006187 P-loop; other site 158190006188 Magnesium ion binding site [ion binding]; other site 158190006189 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 158190006190 Magnesium ion binding site [ion binding]; other site 158190006191 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 158190006192 ParB-like nuclease domain; Region: ParBc; pfam02195 158190006193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 158190006194 salt bridge; other site 158190006195 sequence-specific DNA binding site [nucleotide binding]; other site 158190006196 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 158190006197 active site 158190006198 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 158190006199 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 158190006200 DNA repair protein RadA; Provisional; Region: PRK11823 158190006201 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 158190006202 Walker A motif; other site 158190006203 ATP binding site [chemical binding]; other site 158190006204 Walker B motif; other site 158190006205 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 158190006206 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 158190006207 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 158190006208 Protein of unknown function DUF45; Region: DUF45; pfam01863 158190006209 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 158190006210 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158190006211 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158190006212 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 158190006213 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 158190006214 catalytic triad [active] 158190006215 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 158190006216 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 158190006217 metal binding site [ion binding]; metal-binding site 158190006218 dimer interface [polypeptide binding]; other site 158190006219 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 158190006220 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 158190006221 active site 158190006222 dimer interface [polypeptide binding]; other site 158190006223 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190006224 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 158190006225 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 158190006226 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 158190006227 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 158190006228 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 158190006229 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 158190006230 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 158190006231 Trehalase; Region: Trehalase; cl17346 158190006232 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 158190006233 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 158190006234 putative metal binding site [ion binding]; other site 158190006235 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 158190006236 HSP70 interaction site [polypeptide binding]; other site 158190006237 recombination protein RecR; Reviewed; Region: recR; PRK00076 158190006238 RecR protein; Region: RecR; pfam02132 158190006239 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 158190006240 putative active site [active] 158190006241 putative metal-binding site [ion binding]; other site 158190006242 tetramer interface [polypeptide binding]; other site 158190006243 hypothetical protein; Validated; Region: PRK00153 158190006244 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 158190006245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190006246 Walker A motif; other site 158190006247 ATP binding site [chemical binding]; other site 158190006248 Walker B motif; other site 158190006249 arginine finger; other site 158190006250 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 158190006251 Peptidase family M28; Region: Peptidase_M28; pfam04389 158190006252 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 158190006253 metal binding site [ion binding]; metal-binding site 158190006254 Uncharacterized conserved protein [Function unknown]; Region: COG1739 158190006255 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 158190006256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158190006257 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158190006258 active site 158190006259 catalytic tetrad [active] 158190006260 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 158190006261 putative active site [active] 158190006262 nucleotide binding site [chemical binding]; other site 158190006263 nudix motif; other site 158190006264 putative metal binding site [ion binding]; other site 158190006265 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 158190006266 intersubunit interface [polypeptide binding]; other site 158190006267 active site 158190006268 catalytic residue [active] 158190006269 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 158190006270 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158190006271 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 158190006272 Metal-binding active site; metal-binding site 158190006273 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 158190006274 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 158190006275 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 158190006276 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 158190006277 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 158190006278 dimer interface [polypeptide binding]; other site 158190006279 active site 158190006280 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 158190006281 YibE/F-like protein; Region: YibE_F; pfam07907 158190006282 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190006283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190006284 Walker A/P-loop; other site 158190006285 ATP binding site [chemical binding]; other site 158190006286 Q-loop/lid; other site 158190006287 ABC transporter signature motif; other site 158190006288 Walker B; other site 158190006289 D-loop; other site 158190006290 H-loop/switch region; other site 158190006291 TOBE domain; Region: TOBE_2; pfam08402 158190006292 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158190006293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190006294 dimer interface [polypeptide binding]; other site 158190006295 conserved gate region; other site 158190006296 putative PBP binding loops; other site 158190006297 ABC-ATPase subunit interface; other site 158190006298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190006299 dimer interface [polypeptide binding]; other site 158190006300 conserved gate region; other site 158190006301 putative PBP binding loops; other site 158190006302 ABC-ATPase subunit interface; other site 158190006303 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190006304 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 158190006305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190006306 Coenzyme A binding pocket [chemical binding]; other site 158190006307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 158190006308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190006309 Coenzyme A binding pocket [chemical binding]; other site 158190006310 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 158190006311 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 158190006312 active site 158190006313 intersubunit interface [polypeptide binding]; other site 158190006314 catalytic residue [active] 158190006315 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158190006316 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 158190006317 substrate binding site [chemical binding]; other site 158190006318 ATP binding site [chemical binding]; other site 158190006319 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 158190006320 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 158190006321 diiron binding motif [ion binding]; other site 158190006322 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 158190006323 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 158190006324 putative acyl-acceptor binding pocket; other site 158190006325 Cupin domain; Region: Cupin_2; pfam07883 158190006326 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190006327 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190006328 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190006329 Transcriptional regulator [Transcription]; Region: IclR; COG1414 158190006330 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 158190006331 Bacterial transcriptional regulator; Region: IclR; pfam01614 158190006332 Glucuronate isomerase; Region: UxaC; pfam02614 158190006333 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 158190006334 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 158190006335 galactarate dehydratase; Region: galactar-dH20; TIGR03248 158190006336 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 158190006337 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 158190006338 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 158190006339 Sodium Bile acid symporter family; Region: SBF; cl17470 158190006340 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190006341 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190006342 ligand binding site [chemical binding]; other site 158190006343 dimerization interface [polypeptide binding]; other site 158190006344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190006345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190006346 dimer interface [polypeptide binding]; other site 158190006347 phosphorylation site [posttranslational modification] 158190006348 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190006349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190006350 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190006351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190006352 dimer interface [polypeptide binding]; other site 158190006353 conserved gate region; other site 158190006354 ABC-ATPase subunit interface; other site 158190006355 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190006356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190006357 dimer interface [polypeptide binding]; other site 158190006358 conserved gate region; other site 158190006359 putative PBP binding loops; other site 158190006360 ABC-ATPase subunit interface; other site 158190006361 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190006362 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 158190006363 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190006364 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 158190006365 ligand binding site [chemical binding]; other site 158190006366 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190006367 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190006368 Walker A/P-loop; other site 158190006369 ATP binding site [chemical binding]; other site 158190006370 Q-loop/lid; other site 158190006371 ABC transporter signature motif; other site 158190006372 Walker B; other site 158190006373 D-loop; other site 158190006374 H-loop/switch region; other site 158190006375 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190006376 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190006377 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190006378 TM-ABC transporter signature motif; other site 158190006379 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190006380 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190006381 TM-ABC transporter signature motif; other site 158190006382 purine nucleoside phosphorylase; Provisional; Region: PRK08202 158190006383 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 158190006384 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 158190006385 classical (c) SDRs; Region: SDR_c; cd05233 158190006386 NAD(P) binding site [chemical binding]; other site 158190006387 active site 158190006388 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158190006389 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190006390 active site 158190006391 metal binding site [ion binding]; metal-binding site 158190006392 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 158190006393 ParB-like nuclease domain; Region: ParBc; cl02129 158190006394 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 158190006395 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158190006396 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158190006397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190006398 Walker A/P-loop; other site 158190006399 ATP binding site [chemical binding]; other site 158190006400 Q-loop/lid; other site 158190006401 ABC transporter signature motif; other site 158190006402 Walker B; other site 158190006403 D-loop; other site 158190006404 H-loop/switch region; other site 158190006405 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190006406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190006407 DNA-binding site [nucleotide binding]; DNA binding site 158190006408 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190006409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190006410 DNA-binding site [nucleotide binding]; DNA binding site 158190006411 FCD domain; Region: FCD; pfam07729 158190006412 MarR family; Region: MarR_2; cl17246 158190006413 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190006414 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190006415 nucleotide binding site [chemical binding]; other site 158190006416 heat shock protein 90; Provisional; Region: PRK05218 158190006417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190006418 ATP binding site [chemical binding]; other site 158190006419 Mg2+ binding site [ion binding]; other site 158190006420 G-X-G motif; other site 158190006421 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 158190006422 Mechanosensitive ion channel; Region: MS_channel; pfam00924 158190006423 Propionate catabolism activator; Region: PrpR_N; pfam06506 158190006424 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 158190006425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190006426 Walker B motif; other site 158190006427 arginine finger; other site 158190006428 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 158190006429 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 158190006430 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158190006431 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 158190006432 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 158190006433 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 158190006434 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 158190006435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158190006436 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158190006437 active site 158190006438 catalytic tetrad [active] 158190006439 Uncharacterized conserved protein [Function unknown]; Region: COG2006 158190006440 Domain of unknown function (DUF362); Region: DUF362; pfam04015 158190006441 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 158190006442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190006443 DNA-binding site [nucleotide binding]; DNA binding site 158190006444 FCD domain; Region: FCD; pfam07729 158190006445 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158190006446 TPP-binding site [chemical binding]; other site 158190006447 dimer interface [polypeptide binding]; other site 158190006448 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 158190006449 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158190006450 PYR/PP interface [polypeptide binding]; other site 158190006451 dimer interface [polypeptide binding]; other site 158190006452 TPP binding site [chemical binding]; other site 158190006453 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158190006454 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190006455 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 158190006456 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 158190006457 intersubunit interface [polypeptide binding]; other site 158190006458 ABC-ATPase subunit interface; other site 158190006459 dimer interface [polypeptide binding]; other site 158190006460 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 158190006461 putative PBP binding regions; other site 158190006462 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 158190006463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190006464 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 158190006465 Walker A/P-loop; other site 158190006466 ATP binding site [chemical binding]; other site 158190006467 Q-loop/lid; other site 158190006468 ABC transporter signature motif; other site 158190006469 Walker B; other site 158190006470 D-loop; other site 158190006471 H-loop/switch region; other site 158190006472 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 158190006473 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190006474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190006475 DNA-binding site [nucleotide binding]; DNA binding site 158190006476 FCD domain; Region: FCD; pfam07729 158190006477 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 158190006478 fructuronate transporter; Provisional; Region: PRK10034; cl15264 158190006479 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 158190006480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190006481 binding surface 158190006482 TPR motif; other site 158190006483 TPR repeat; Region: TPR_11; pfam13414 158190006484 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 158190006485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190006486 S-adenosylmethionine binding site [chemical binding]; other site 158190006487 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 158190006488 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 158190006489 adenosine deaminase; Provisional; Region: PRK09358 158190006490 active site 158190006491 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 158190006492 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 158190006493 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158190006494 prolyl-tRNA synthetase; Provisional; Region: PRK09194 158190006495 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 158190006496 dimer interface [polypeptide binding]; other site 158190006497 motif 1; other site 158190006498 active site 158190006499 motif 2; other site 158190006500 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 158190006501 putative deacylase active site [active] 158190006502 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 158190006503 active site 158190006504 motif 3; other site 158190006505 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 158190006506 anticodon binding site; other site 158190006507 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 158190006508 intersubunit interface [polypeptide binding]; other site 158190006509 active site 158190006510 Zn2+ binding site [ion binding]; other site 158190006511 transketolase; Reviewed; Region: PRK05899 158190006512 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158190006513 TPP-binding site [chemical binding]; other site 158190006514 dimer interface [polypeptide binding]; other site 158190006515 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 158190006516 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158190006517 PYR/PP interface [polypeptide binding]; other site 158190006518 dimer interface [polypeptide binding]; other site 158190006519 TPP binding site [chemical binding]; other site 158190006520 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158190006521 OsmC-like protein; Region: OsmC; pfam02566 158190006522 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 158190006523 Cation efflux family; Region: Cation_efflux; pfam01545 158190006524 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 158190006525 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 158190006526 dimer interface [polypeptide binding]; other site 158190006527 anticodon binding site; other site 158190006528 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 158190006529 homodimer interface [polypeptide binding]; other site 158190006530 motif 1; other site 158190006531 active site 158190006532 motif 2; other site 158190006533 GAD domain; Region: GAD; pfam02938 158190006534 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 158190006535 active site 158190006536 motif 3; other site 158190006537 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 158190006538 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158190006539 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 158190006540 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 158190006541 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 158190006542 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158190006543 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 158190006544 IMP binding site; other site 158190006545 dimer interface [polypeptide binding]; other site 158190006546 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 158190006547 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 158190006548 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 158190006549 catalytic site [active] 158190006550 subunit interface [polypeptide binding]; other site 158190006551 PspC domain; Region: PspC; cl00864 158190006552 phage shock protein A; Region: phageshock_pspA; TIGR02977 158190006553 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 158190006554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190006555 Walker A motif; other site 158190006556 ATP binding site [chemical binding]; other site 158190006557 Walker B motif; other site 158190006558 arginine finger; other site 158190006559 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 158190006560 PspC domain; Region: PspC; cl00864 158190006561 phage shock protein A; Region: phageshock_pspA; TIGR02977 158190006562 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 158190006563 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 158190006564 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 158190006565 phage shock protein C; Region: phageshock_pspC; TIGR02978 158190006566 phage shock protein A; Region: phageshock_pspA; TIGR02977 158190006567 PspC domain; Region: PspC; cl00864 158190006568 phage shock protein A; Region: phageshock_pspA; TIGR02977 158190006569 Predicted methyltransferases [General function prediction only]; Region: COG0313 158190006570 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 158190006571 putative SAM binding site [chemical binding]; other site 158190006572 putative homodimer interface [polypeptide binding]; other site 158190006573 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 158190006574 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 158190006575 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 158190006576 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190006577 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 158190006578 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 158190006579 Uncharacterized conserved protein [Function unknown]; Region: COG0327 158190006580 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 158190006581 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 158190006582 Cytochrome c oxidase assembly protein COX16; Region: COX16; pfam14138 158190006583 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 158190006584 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 158190006585 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 158190006586 active site 158190006587 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 158190006588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190006589 S-adenosylmethionine binding site [chemical binding]; other site 158190006590 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 158190006591 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 158190006592 ssDNA binding site; other site 158190006593 generic binding surface II; other site 158190006594 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190006595 ATP binding site [chemical binding]; other site 158190006596 putative Mg++ binding site [ion binding]; other site 158190006597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190006598 nucleotide binding region [chemical binding]; other site 158190006599 ATP-binding site [chemical binding]; other site 158190006600 YGGT family; Region: YGGT; pfam02325 158190006601 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 158190006602 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 158190006603 active site 158190006604 PHP Thumb interface [polypeptide binding]; other site 158190006605 metal binding site [ion binding]; metal-binding site 158190006606 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 158190006607 generic binding surface I; other site 158190006608 generic binding surface II; other site 158190006609 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 158190006610 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 158190006611 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 158190006612 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 158190006613 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190006614 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 158190006615 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 158190006616 nucleotide binding pocket [chemical binding]; other site 158190006617 K-X-D-G motif; other site 158190006618 catalytic site [active] 158190006619 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 158190006620 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 158190006621 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 158190006622 Dimer interface [polypeptide binding]; other site 158190006623 BRCT sequence motif; other site 158190006624 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 158190006625 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158190006626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190006627 homodimer interface [polypeptide binding]; other site 158190006628 catalytic residue [active] 158190006629 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 158190006630 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 158190006631 6-phosphofructokinase; Region: PLN02884 158190006632 active site 158190006633 ADP/pyrophosphate binding site [chemical binding]; other site 158190006634 dimerization interface [polypeptide binding]; other site 158190006635 allosteric effector site; other site 158190006636 fructose-1,6-bisphosphate binding site; other site 158190006637 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 158190006638 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 158190006639 active site 158190006640 dimer interface [polypeptide binding]; other site 158190006641 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 158190006642 dimer interface [polypeptide binding]; other site 158190006643 active site 158190006644 Arginine repressor [Transcription]; Region: ArgR; COG1438 158190006645 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 158190006646 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 158190006647 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 158190006648 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 158190006649 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 158190006650 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 158190006651 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 158190006652 Integral membrane protein DUF92; Region: DUF92; pfam01940 158190006653 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 158190006654 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 158190006655 ring oligomerisation interface [polypeptide binding]; other site 158190006656 ATP/Mg binding site [chemical binding]; other site 158190006657 stacking interactions; other site 158190006658 hinge regions; other site 158190006659 Preprotein translocase subunit; Region: YajC; pfam02699 158190006660 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 158190006661 protein-export membrane protein SecD; Region: secD; TIGR01129 158190006662 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 158190006663 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 158190006664 Protein export membrane protein; Region: SecD_SecF; pfam02355 158190006665 LytB protein; Region: LYTB; cl00507 158190006666 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 158190006667 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 158190006668 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 158190006669 CoA binding domain; Region: CoA_binding; smart00881 158190006670 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 158190006671 dimer interface [polypeptide binding]; other site 158190006672 [2Fe-2S] cluster binding site [ion binding]; other site 158190006673 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190006674 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 158190006675 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158190006676 Putative Fe-S cluster; Region: FeS; cl17515 158190006677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158190006678 PAS domain; Region: PAS_9; pfam13426 158190006679 putative active site [active] 158190006680 heme pocket [chemical binding]; other site 158190006681 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 158190006682 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 158190006683 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 158190006684 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190006685 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158190006686 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 158190006687 GAF domain; Region: GAF_2; pfam13185 158190006688 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 158190006689 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 158190006690 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 158190006691 active site 158190006692 dimer interface [polypeptide binding]; other site 158190006693 motif 1; other site 158190006694 motif 2; other site 158190006695 motif 3; other site 158190006696 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 158190006697 anticodon binding site; other site 158190006698 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 158190006699 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 158190006700 active site 158190006701 Zn binding site [ion binding]; other site 158190006702 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 158190006703 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 158190006704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 158190006705 active site 158190006706 motif I; other site 158190006707 motif II; other site 158190006708 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 158190006709 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 158190006710 Walker A/P-loop; other site 158190006711 ATP binding site [chemical binding]; other site 158190006712 Q-loop/lid; other site 158190006713 ABC transporter signature motif; other site 158190006714 Walker B; other site 158190006715 D-loop; other site 158190006716 H-loop/switch region; other site 158190006717 NIL domain; Region: NIL; pfam09383 158190006718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190006719 ABC-ATPase subunit interface; other site 158190006720 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 158190006721 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 158190006722 ornithine carbamoyltransferase; Validated; Region: PRK02102 158190006723 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 158190006724 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 158190006725 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 158190006726 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 158190006727 putative dimer interface [polypeptide binding]; other site 158190006728 hypothetical protein; Provisional; Region: PRK08262 158190006729 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 158190006730 metal binding site [ion binding]; metal-binding site 158190006731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190006732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190006733 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 158190006734 Clp amino terminal domain; Region: Clp_N; pfam02861 158190006735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190006736 Walker A motif; other site 158190006737 ATP binding site [chemical binding]; other site 158190006738 Walker B motif; other site 158190006739 arginine finger; other site 158190006740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190006741 Walker A motif; other site 158190006742 ATP binding site [chemical binding]; other site 158190006743 Walker B motif; other site 158190006744 arginine finger; other site 158190006745 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 158190006746 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 158190006747 Ligand binding site; other site 158190006748 metal-binding site 158190006749 Protein of unknown function (DUF554); Region: DUF554; pfam04474 158190006750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190006751 sequence-specific DNA binding site [nucleotide binding]; other site 158190006752 salt bridge; other site 158190006753 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 158190006754 homodimer interface [polypeptide binding]; other site 158190006755 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 158190006756 active site pocket [active] 158190006757 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 158190006758 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 158190006759 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 158190006760 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 158190006761 putative homodimer interface [polypeptide binding]; other site 158190006762 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 158190006763 heterodimer interface [polypeptide binding]; other site 158190006764 homodimer interface [polypeptide binding]; other site 158190006765 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 158190006766 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 158190006767 23S rRNA interface [nucleotide binding]; other site 158190006768 L7/L12 interface [polypeptide binding]; other site 158190006769 putative thiostrepton binding site; other site 158190006770 L25 interface [polypeptide binding]; other site 158190006771 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 158190006772 mRNA/rRNA interface [nucleotide binding]; other site 158190006773 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 158190006774 23S rRNA interface [nucleotide binding]; other site 158190006775 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 158190006776 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 158190006777 core dimer interface [polypeptide binding]; other site 158190006778 peripheral dimer interface [polypeptide binding]; other site 158190006779 L10 interface [polypeptide binding]; other site 158190006780 L11 interface [polypeptide binding]; other site 158190006781 putative EF-Tu interaction site [polypeptide binding]; other site 158190006782 putative EF-G interaction site [polypeptide binding]; other site 158190006783 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 158190006784 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 158190006785 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 158190006786 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 158190006787 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 158190006788 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 158190006789 RPB10 interaction site [polypeptide binding]; other site 158190006790 RPB1 interaction site [polypeptide binding]; other site 158190006791 RPB11 interaction site [polypeptide binding]; other site 158190006792 RPB3 interaction site [polypeptide binding]; other site 158190006793 RPB12 interaction site [polypeptide binding]; other site 158190006794 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 158190006795 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 158190006796 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 158190006797 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 158190006798 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 158190006799 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 158190006800 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 158190006801 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 158190006802 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 158190006803 DNA binding site [nucleotide binding] 158190006804 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 158190006805 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 158190006806 S17 interaction site [polypeptide binding]; other site 158190006807 S8 interaction site; other site 158190006808 16S rRNA interaction site [nucleotide binding]; other site 158190006809 streptomycin interaction site [chemical binding]; other site 158190006810 23S rRNA interaction site [nucleotide binding]; other site 158190006811 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 158190006812 30S ribosomal protein S7; Validated; Region: PRK05302 158190006813 elongation factor Tu; Reviewed; Region: PRK00049 158190006814 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 158190006815 G1 box; other site 158190006816 GEF interaction site [polypeptide binding]; other site 158190006817 GTP/Mg2+ binding site [chemical binding]; other site 158190006818 Switch I region; other site 158190006819 G2 box; other site 158190006820 G3 box; other site 158190006821 Switch II region; other site 158190006822 G4 box; other site 158190006823 G5 box; other site 158190006824 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 158190006825 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 158190006826 Antibiotic Binding Site [chemical binding]; other site 158190006827 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 158190006828 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 158190006829 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 158190006830 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 158190006831 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 158190006832 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 158190006833 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 158190006834 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 158190006835 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 158190006836 putative translocon binding site; other site 158190006837 protein-rRNA interface [nucleotide binding]; other site 158190006838 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 158190006839 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 158190006840 G-X-X-G motif; other site 158190006841 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 158190006842 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 158190006843 23S rRNA interface [nucleotide binding]; other site 158190006844 5S rRNA interface [nucleotide binding]; other site 158190006845 putative antibiotic binding site [chemical binding]; other site 158190006846 L25 interface [polypeptide binding]; other site 158190006847 L27 interface [polypeptide binding]; other site 158190006848 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 158190006849 23S rRNA interface [nucleotide binding]; other site 158190006850 putative translocon interaction site; other site 158190006851 signal recognition particle (SRP54) interaction site; other site 158190006852 L23 interface [polypeptide binding]; other site 158190006853 trigger factor interaction site; other site 158190006854 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 158190006855 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 158190006856 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 158190006857 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 158190006858 RNA binding site [nucleotide binding]; other site 158190006859 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 158190006860 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 158190006861 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 158190006862 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 158190006863 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 158190006864 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 158190006865 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 158190006866 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 158190006867 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 158190006868 23S rRNA interface [nucleotide binding]; other site 158190006869 L21e interface [polypeptide binding]; other site 158190006870 5S rRNA interface [nucleotide binding]; other site 158190006871 L27 interface [polypeptide binding]; other site 158190006872 L5 interface [polypeptide binding]; other site 158190006873 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 158190006874 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 158190006875 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 158190006876 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 158190006877 23S rRNA binding site [nucleotide binding]; other site 158190006878 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 158190006879 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 158190006880 SecY translocase; Region: SecY; pfam00344 158190006881 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 158190006882 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 158190006883 30S ribosomal protein S13; Region: bact_S13; TIGR03631 158190006884 30S ribosomal protein S11; Validated; Region: PRK05309 158190006885 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 158190006886 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 158190006887 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 158190006888 RNA binding surface [nucleotide binding]; other site 158190006889 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 158190006890 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 158190006891 alphaNTD - beta interaction site [polypeptide binding]; other site 158190006892 alphaNTD homodimer interface [polypeptide binding]; other site 158190006893 alphaNTD - beta' interaction site [polypeptide binding]; other site 158190006894 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 158190006895 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 158190006896 phosphodiesterase; Provisional; Region: PRK12704 158190006897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190006898 Zn2+ binding site [ion binding]; other site 158190006899 Mg2+ binding site [ion binding]; other site 158190006900 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 158190006901 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158190006902 putative active site [active] 158190006903 metal binding site [ion binding]; metal-binding site 158190006904 homodimer binding site [polypeptide binding]; other site 158190006905 hemolysin TlyA family protein; Region: tly; TIGR00478 158190006906 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 158190006907 Sporulation and spore germination; Region: Germane; pfam10646 158190006908 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 158190006909 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 158190006910 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 158190006911 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 158190006912 GTP-binding protein Der; Reviewed; Region: PRK00093 158190006913 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 158190006914 G1 box; other site 158190006915 GTP/Mg2+ binding site [chemical binding]; other site 158190006916 Switch I region; other site 158190006917 G2 box; other site 158190006918 Switch II region; other site 158190006919 G3 box; other site 158190006920 G4 box; other site 158190006921 G5 box; other site 158190006922 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 158190006923 G1 box; other site 158190006924 GTP/Mg2+ binding site [chemical binding]; other site 158190006925 Switch I region; other site 158190006926 G2 box; other site 158190006927 G3 box; other site 158190006928 Switch II region; other site 158190006929 G4 box; other site 158190006930 G5 box; other site 158190006931 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 158190006932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190006933 motif II; other site 158190006934 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 158190006935 GrpE; Region: GrpE; pfam01025 158190006936 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 158190006937 dimer interface [polypeptide binding]; other site 158190006938 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 158190006939 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 158190006940 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 158190006941 nucleotide binding site [chemical binding]; other site 158190006942 NEF interaction site [polypeptide binding]; other site 158190006943 SBD interface [polypeptide binding]; other site 158190006944 chaperone protein DnaJ; Provisional; Region: PRK10767 158190006945 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 158190006946 HSP70 interaction site [polypeptide binding]; other site 158190006947 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 158190006948 substrate binding site [polypeptide binding]; other site 158190006949 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 158190006950 Zn binding sites [ion binding]; other site 158190006951 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 158190006952 dimer interface [polypeptide binding]; other site 158190006953 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 158190006954 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 158190006955 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 158190006956 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190006957 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190006958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190006959 Walker A/P-loop; other site 158190006960 ATP binding site [chemical binding]; other site 158190006961 Q-loop/lid; other site 158190006962 ABC transporter signature motif; other site 158190006963 Walker B; other site 158190006964 D-loop; other site 158190006965 H-loop/switch region; other site 158190006966 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190006967 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 158190006968 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190006969 TM-ABC transporter signature motif; other site 158190006970 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 158190006971 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190006972 TM-ABC transporter signature motif; other site 158190006973 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 158190006974 DsrE/DsrF-like family; Region: DrsE; cl00672 158190006975 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 158190006976 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 158190006977 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158190006978 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 158190006979 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 158190006980 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 158190006981 FMN binding site [chemical binding]; other site 158190006982 active site 158190006983 catalytic residues [active] 158190006984 substrate binding site [chemical binding]; other site 158190006985 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 158190006986 active site 158190006987 PSP1 C-terminal conserved region; Region: PSP1; cl00770 158190006988 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 158190006989 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 158190006990 IHF - DNA interface [nucleotide binding]; other site 158190006991 IHF dimer interface [polypeptide binding]; other site 158190006992 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 158190006993 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 158190006994 putative active site [active] 158190006995 catalytic triad [active] 158190006996 putative dimer interface [polypeptide binding]; other site 158190006997 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 158190006998 competence damage-inducible protein A; Provisional; Region: PRK00549 158190006999 putative MPT binding site; other site 158190007000 Competence-damaged protein; Region: CinA; pfam02464 158190007001 transcription termination factor Rho; Provisional; Region: rho; PRK09376 158190007002 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 158190007003 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 158190007004 RNA binding site [nucleotide binding]; other site 158190007005 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 158190007006 multimer interface [polypeptide binding]; other site 158190007007 Walker A motif; other site 158190007008 ATP binding site [chemical binding]; other site 158190007009 Walker B motif; other site 158190007010 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 158190007011 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 158190007012 Survival protein SurE; Region: SurE; cl00448 158190007013 Flagellin N-methylase; Region: FliB; cl00497 158190007014 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 158190007015 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 158190007016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190007017 catalytic residue [active] 158190007018 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 158190007019 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 158190007020 trimerization site [polypeptide binding]; other site 158190007021 active site 158190007022 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 158190007023 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158190007024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158190007025 DNA binding residues [nucleotide binding] 158190007026 dimerization interface [polypeptide binding]; other site 158190007027 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 158190007028 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 158190007029 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 158190007030 active site 158190007031 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 158190007032 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 158190007033 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 158190007034 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190007035 active site 158190007036 metal binding site [ion binding]; metal-binding site 158190007037 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190007038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190007039 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 158190007040 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 158190007041 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158190007042 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 158190007043 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 158190007044 ZIP Zinc transporter; Region: Zip; pfam02535 158190007045 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 158190007046 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 158190007047 [2Fe-2S] cluster binding site [ion binding]; other site 158190007048 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 158190007049 hydrophobic ligand binding site; other site 158190007050 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 158190007051 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 158190007052 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158190007053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158190007054 ligand binding site [chemical binding]; other site 158190007055 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 158190007056 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190007057 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158190007058 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158190007059 FtsX-like permease family; Region: FtsX; pfam02687 158190007060 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158190007061 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158190007062 FtsX-like permease family; Region: FtsX; pfam02687 158190007063 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158190007064 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158190007065 Walker A/P-loop; other site 158190007066 ATP binding site [chemical binding]; other site 158190007067 Q-loop/lid; other site 158190007068 ABC transporter signature motif; other site 158190007069 Walker B; other site 158190007070 D-loop; other site 158190007071 H-loop/switch region; other site 158190007072 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 158190007073 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 158190007074 Predicted transcriptional regulators [Transcription]; Region: COG1725 158190007075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190007076 DNA-binding site [nucleotide binding]; DNA binding site 158190007077 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158190007078 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158190007079 FtsX-like permease family; Region: FtsX; pfam02687 158190007080 Pirin-related protein [General function prediction only]; Region: COG1741 158190007081 Pirin; Region: Pirin; pfam02678 158190007082 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 158190007083 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 158190007084 Ferritin-like domain; Region: Ferritin; pfam00210 158190007085 ferroxidase diiron center [ion binding]; other site 158190007086 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 158190007087 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 158190007088 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 158190007089 TrkA-N domain; Region: TrkA_N; pfam02254 158190007090 TrkA-C domain; Region: TrkA_C; pfam02080 158190007091 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 158190007092 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 158190007093 trimer interface [polypeptide binding]; other site 158190007094 putative metal binding site [ion binding]; other site 158190007095 xanthine permease; Region: pbuX; TIGR03173 158190007096 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 158190007097 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 158190007098 intersubunit interface [polypeptide binding]; other site 158190007099 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158190007100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190007101 Walker A/P-loop; other site 158190007102 ATP binding site [chemical binding]; other site 158190007103 Q-loop/lid; other site 158190007104 ABC transporter signature motif; other site 158190007105 Walker B; other site 158190007106 D-loop; other site 158190007107 H-loop/switch region; other site 158190007108 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 158190007109 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158190007110 ABC-ATPase subunit interface; other site 158190007111 dimer interface [polypeptide binding]; other site 158190007112 putative PBP binding regions; other site 158190007113 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 158190007114 metal binding site 2 [ion binding]; metal-binding site 158190007115 putative DNA binding helix; other site 158190007116 metal binding site 1 [ion binding]; metal-binding site 158190007117 dimer interface [polypeptide binding]; other site 158190007118 structural Zn2+ binding site [ion binding]; other site 158190007119 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 158190007120 active site 158190007121 metal-binding site [ion binding] 158190007122 nucleotide-binding site [chemical binding]; other site 158190007123 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 158190007124 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190007125 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 158190007126 MreB and similar proteins; Region: MreB_like; cd10225 158190007127 nucleotide binding site [chemical binding]; other site 158190007128 Mg binding site [ion binding]; other site 158190007129 putative protofilament interaction site [polypeptide binding]; other site 158190007130 RodZ interaction site [polypeptide binding]; other site 158190007131 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 158190007132 MreB and similar proteins; Region: MreB_like; cd10225 158190007133 nucleotide binding site [chemical binding]; other site 158190007134 Mg binding site [ion binding]; other site 158190007135 putative protofilament interaction site [polypeptide binding]; other site 158190007136 RodZ interaction site [polypeptide binding]; other site 158190007137 rod shape-determining protein MreB; Provisional; Region: PRK13930 158190007138 MreB and similar proteins; Region: MreB_like; cd10225 158190007139 nucleotide binding site [chemical binding]; other site 158190007140 Mg binding site [ion binding]; other site 158190007141 putative protofilament interaction site [polypeptide binding]; other site 158190007142 RodZ interaction site [polypeptide binding]; other site 158190007143 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158190007144 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158190007145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158190007146 dimerization interface [polypeptide binding]; other site 158190007147 DNA binding residues [nucleotide binding] 158190007148 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 158190007149 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 158190007150 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 158190007151 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 158190007152 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 158190007153 active site 158190007154 catalytic site [active] 158190007155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190007156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190007157 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 158190007158 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 158190007159 domain interfaces; other site 158190007160 active site 158190007161 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 158190007162 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158190007163 active site 158190007164 O-Antigen ligase; Region: Wzy_C; pfam04932 158190007165 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 158190007166 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 158190007167 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 158190007168 Chain length determinant protein; Region: Wzz; pfam02706 158190007169 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 158190007170 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158190007171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158190007172 PAS domain; Region: PAS_9; pfam13426 158190007173 putative active site [active] 158190007174 heme pocket [chemical binding]; other site 158190007175 GAF domain; Region: GAF; pfam01590 158190007176 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 158190007177 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 158190007178 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 158190007179 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 158190007180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190007181 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 158190007182 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 158190007183 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158190007184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 158190007185 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 158190007186 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 158190007187 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 158190007188 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 158190007189 anti sigma factor interaction site; other site 158190007190 regulatory phosphorylation site [posttranslational modification]; other site 158190007191 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 158190007192 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 158190007193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158190007194 active site 158190007195 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 158190007196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 158190007197 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 158190007198 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 158190007199 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 158190007200 Bacterial sugar transferase; Region: Bac_transf; pfam02397 158190007201 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190007202 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 158190007203 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190007204 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 158190007205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190007206 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 158190007207 PAS domain S-box; Region: sensory_box; TIGR00229 158190007208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158190007209 putative active site [active] 158190007210 heme pocket [chemical binding]; other site 158190007211 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190007212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190007213 metal binding site [ion binding]; metal-binding site 158190007214 active site 158190007215 I-site; other site 158190007216 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 158190007217 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 158190007218 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 158190007219 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 158190007220 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 158190007221 catalytic residue [active] 158190007222 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190007223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190007224 metal binding site [ion binding]; metal-binding site 158190007225 active site 158190007226 I-site; other site 158190007227 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 158190007228 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 158190007229 active site 158190007230 Creatinine amidohydrolase; Region: Creatininase; cl00618 158190007231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190007232 putative substrate translocation pore; other site 158190007233 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 158190007234 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 158190007235 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 158190007236 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 158190007237 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 158190007238 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190007239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007240 dimer interface [polypeptide binding]; other site 158190007241 conserved gate region; other site 158190007242 putative PBP binding loops; other site 158190007243 ABC-ATPase subunit interface; other site 158190007244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007245 dimer interface [polypeptide binding]; other site 158190007246 conserved gate region; other site 158190007247 putative PBP binding loops; other site 158190007248 ABC-ATPase subunit interface; other site 158190007249 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190007250 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190007251 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190007252 DNA binding site [nucleotide binding] 158190007253 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190007254 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 158190007255 Helix-turn-helix domain; Region: HTH_18; pfam12833 158190007256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190007257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190007258 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190007259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190007260 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 158190007261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158190007262 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190007263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190007264 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190007265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007266 dimer interface [polypeptide binding]; other site 158190007267 conserved gate region; other site 158190007268 putative PBP binding loops; other site 158190007269 ABC-ATPase subunit interface; other site 158190007270 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190007271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007272 dimer interface [polypeptide binding]; other site 158190007273 conserved gate region; other site 158190007274 putative PBP binding loops; other site 158190007275 ABC-ATPase subunit interface; other site 158190007276 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 158190007277 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 158190007278 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 158190007279 FMN binding site [chemical binding]; other site 158190007280 dimer interface [polypeptide binding]; other site 158190007281 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 158190007282 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 158190007283 Putative esterase; Region: Esterase; pfam00756 158190007284 S-formylglutathione hydrolase; Region: PLN02442 158190007285 homoserine O-succinyltransferase; Provisional; Region: PRK05368 158190007286 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 158190007287 proposed active site lysine [active] 158190007288 conserved cys residue [active] 158190007289 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 158190007290 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 158190007291 homodimer interface [polypeptide binding]; other site 158190007292 substrate-cofactor binding pocket; other site 158190007293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190007294 catalytic residue [active] 158190007295 Predicted transcriptional regulators [Transcription]; Region: COG1695 158190007296 Transcriptional regulator PadR-like family; Region: PadR; cl17335 158190007297 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 158190007298 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158190007299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190007300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190007301 putative substrate translocation pore; other site 158190007302 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 158190007303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190007304 ATP binding site [chemical binding]; other site 158190007305 putative Mg++ binding site [ion binding]; other site 158190007306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190007307 nucleotide binding region [chemical binding]; other site 158190007308 ATP-binding site [chemical binding]; other site 158190007309 RQC domain; Region: RQC; pfam09382 158190007310 HRDC domain; Region: HRDC; pfam00570 158190007311 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190007312 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 158190007313 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 158190007314 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 158190007315 putative ligand binding site [chemical binding]; other site 158190007316 putative NAD binding site [chemical binding]; other site 158190007317 catalytic site [active] 158190007318 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 158190007319 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 158190007320 YheO-like PAS domain; Region: PAS_6; pfam08348 158190007321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 158190007322 HTH domain; Region: HTH_22; pfam13309 158190007323 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 158190007324 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158190007325 phosphate binding site [ion binding]; other site 158190007326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190007327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190007328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190007329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190007330 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 158190007331 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 158190007332 E3 interaction surface; other site 158190007333 lipoyl attachment site [posttranslational modification]; other site 158190007334 HlyD family secretion protein; Region: HlyD_3; pfam13437 158190007335 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 158190007336 Peptidase family M23; Region: Peptidase_M23; pfam01551 158190007337 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 158190007338 catalytic core [active] 158190007339 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 158190007340 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 158190007341 RNB domain; Region: RNB; pfam00773 158190007342 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 158190007343 RNA binding site [nucleotide binding]; other site 158190007344 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 158190007345 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 158190007346 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158190007347 active site 158190007348 phosphorylation site [posttranslational modification] 158190007349 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 158190007350 photolyase PhrII; Region: phr2; TIGR00591 158190007351 DNA photolyase; Region: DNA_photolyase; pfam00875 158190007352 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 158190007353 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 158190007354 Nitrogen regulatory protein P-II; Region: P-II; smart00938 158190007355 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 158190007356 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 158190007357 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158190007358 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 158190007359 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 158190007360 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 158190007361 nudix motif; other site 158190007362 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 158190007363 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 158190007364 putative active site [active] 158190007365 putative metal binding site [ion binding]; other site 158190007366 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 158190007367 Peptidase family U32; Region: Peptidase_U32; pfam01136 158190007368 Collagenase; Region: DUF3656; pfam12392 158190007369 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 158190007370 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 158190007371 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158190007372 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158190007373 ligand binding site [chemical binding]; other site 158190007374 flexible hinge region; other site 158190007375 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 158190007376 active site 158190007377 substrate-binding site [chemical binding]; other site 158190007378 metal-binding site [ion binding] 158190007379 GTP binding site [chemical binding]; other site 158190007380 Predicted transcriptional regulator [Transcription]; Region: COG2378 158190007381 WYL domain; Region: WYL; pfam13280 158190007382 uracil transporter; Provisional; Region: PRK10720 158190007383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190007384 S-adenosylmethionine binding site [chemical binding]; other site 158190007385 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 158190007386 catalytic site [active] 158190007387 putative active site [active] 158190007388 putative substrate binding site [chemical binding]; other site 158190007389 HRDC domain; Region: HRDC; cl02578 158190007390 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 158190007391 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 158190007392 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 158190007393 peptidase T-like protein; Region: PepT-like; TIGR01883 158190007394 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 158190007395 metal binding site [ion binding]; metal-binding site 158190007396 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158190007397 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158190007398 active site 158190007399 catalytic tetrad [active] 158190007400 Domain of unknown function (DU1801); Region: DUF1801; cl17490 158190007401 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190007402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190007403 metal binding site [ion binding]; metal-binding site 158190007404 active site 158190007405 I-site; other site 158190007406 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158190007407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190007408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190007409 metal binding site [ion binding]; metal-binding site 158190007410 active site 158190007411 I-site; other site 158190007412 rarD protein; Region: rarD; TIGR00688 158190007413 EamA-like transporter family; Region: EamA; pfam00892 158190007414 EamA-like transporter family; Region: EamA; pfam00892 158190007415 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 158190007416 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 158190007417 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 158190007418 ligand binding site [chemical binding]; other site 158190007419 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 158190007420 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 158190007421 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 158190007422 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 158190007423 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 158190007424 active site 158190007425 NAD binding site [chemical binding]; other site 158190007426 metal binding site [ion binding]; metal-binding site 158190007427 OsmC-like protein; Region: OsmC; cl00767 158190007428 RibD C-terminal domain; Region: RibD_C; cl17279 158190007429 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 158190007430 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 158190007431 active site 158190007432 catalytic residues [active] 158190007433 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190007434 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190007435 Walker A/P-loop; other site 158190007436 ATP binding site [chemical binding]; other site 158190007437 Q-loop/lid; other site 158190007438 ABC transporter signature motif; other site 158190007439 Walker B; other site 158190007440 D-loop; other site 158190007441 H-loop/switch region; other site 158190007442 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190007443 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190007444 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190007445 TM-ABC transporter signature motif; other site 158190007446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158190007447 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190007448 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158190007449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190007450 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190007451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190007452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190007453 TPR motif; other site 158190007454 binding surface 158190007455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190007456 binding surface 158190007457 TPR motif; other site 158190007458 TPR repeat; Region: TPR_11; pfam13414 158190007459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190007460 binding surface 158190007461 TPR motif; other site 158190007462 Tetratricopeptide repeat; Region: TPR_12; pfam13424 158190007463 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 158190007464 active site 158190007465 catalytic site [active] 158190007466 substrate binding site [chemical binding]; other site 158190007467 Predicted permeases [General function prediction only]; Region: COG0679 158190007468 Protein of unknown function DUF72; Region: DUF72; pfam01904 158190007469 Winged helix-turn helix; Region: HTH_29; pfam13551 158190007470 Homeodomain-like domain; Region: HTH_32; pfam13565 158190007471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190007472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190007473 DNA binding site [nucleotide binding] 158190007474 domain linker motif; other site 158190007475 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190007476 dimerization interface [polypeptide binding]; other site 158190007477 ligand binding site [chemical binding]; other site 158190007478 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190007479 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190007480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007481 dimer interface [polypeptide binding]; other site 158190007482 conserved gate region; other site 158190007483 putative PBP binding loops; other site 158190007484 ABC-ATPase subunit interface; other site 158190007485 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190007486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007487 dimer interface [polypeptide binding]; other site 158190007488 conserved gate region; other site 158190007489 putative PBP binding loops; other site 158190007490 ABC-ATPase subunit interface; other site 158190007491 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 158190007492 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158190007493 nucleotide binding site [chemical binding]; other site 158190007494 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158190007495 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 158190007496 putative NAD(P) binding site [chemical binding]; other site 158190007497 catalytic Zn binding site [ion binding]; other site 158190007498 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 158190007499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190007500 NAD(P) binding site [chemical binding]; other site 158190007501 active site 158190007502 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158190007503 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 158190007504 inhibitor binding site; inhibition site 158190007505 catalytic Zn binding site [ion binding]; other site 158190007506 structural Zn binding site [ion binding]; other site 158190007507 NADP binding site [chemical binding]; other site 158190007508 tetramer interface [polypeptide binding]; other site 158190007509 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 158190007510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190007511 active site 158190007512 phosphorylation site [posttranslational modification] 158190007513 intermolecular recognition site; other site 158190007514 dimerization interface [polypeptide binding]; other site 158190007515 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190007516 Zn2+ binding site [ion binding]; other site 158190007517 Mg2+ binding site [ion binding]; other site 158190007518 Phospholipid methyltransferase; Region: PEMT; cl17370 158190007519 PAS domain; Region: PAS; smart00091 158190007520 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 158190007521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190007522 dimer interface [polypeptide binding]; other site 158190007523 phosphorylation site [posttranslational modification] 158190007524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190007525 ATP binding site [chemical binding]; other site 158190007526 Mg2+ binding site [ion binding]; other site 158190007527 G-X-G motif; other site 158190007528 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158190007529 Uncharacterized conserved protein [Function unknown]; Region: COG1633 158190007530 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 158190007531 diiron binding motif [ion binding]; other site 158190007532 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 158190007533 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190007534 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 158190007535 N- and C-terminal domain interface [polypeptide binding]; other site 158190007536 D-xylulose kinase; Region: XylB; TIGR01312 158190007537 active site 158190007538 MgATP binding site [chemical binding]; other site 158190007539 catalytic site [active] 158190007540 metal binding site [ion binding]; metal-binding site 158190007541 xylulose binding site [chemical binding]; other site 158190007542 homodimer interface [polypeptide binding]; other site 158190007543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190007544 sequence-specific DNA binding site [nucleotide binding]; other site 158190007545 salt bridge; other site 158190007546 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 158190007547 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 158190007548 putative NAD(P) binding site [chemical binding]; other site 158190007549 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 158190007550 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 158190007551 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 158190007552 DctM-like transporters; Region: DctM; pfam06808 158190007553 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 158190007554 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 158190007555 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 158190007556 nudix motif; other site 158190007557 PGAP1-like protein; Region: PGAP1; pfam07819 158190007558 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 158190007559 TIGR01177 family protein; Region: TIGR01177 158190007560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190007561 S-adenosylmethionine binding site [chemical binding]; other site 158190007562 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190007563 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158190007564 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 158190007565 DctM-like transporters; Region: DctM; pfam06808 158190007566 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190007567 Isochorismatase family; Region: Isochorismatase; pfam00857 158190007568 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 158190007569 catalytic triad [active] 158190007570 conserved cis-peptide bond; other site 158190007571 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158190007572 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 158190007573 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 158190007574 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 158190007575 intersubunit interface [polypeptide binding]; other site 158190007576 active site 158190007577 Zn2+ binding site [ion binding]; other site 158190007578 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158190007579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190007580 DNA-binding site [nucleotide binding]; DNA binding site 158190007581 FCD domain; Region: FCD; pfam07729 158190007582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190007583 metal binding site [ion binding]; metal-binding site 158190007584 active site 158190007585 I-site; other site 158190007586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 158190007587 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 158190007588 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 158190007589 DNA binding residues [nucleotide binding] 158190007590 drug binding residues [chemical binding]; other site 158190007591 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 158190007592 Beta-lactamase; Region: Beta-lactamase; pfam00144 158190007593 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 158190007594 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190007595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190007596 Walker A/P-loop; other site 158190007597 ATP binding site [chemical binding]; other site 158190007598 Q-loop/lid; other site 158190007599 ABC transporter signature motif; other site 158190007600 Walker B; other site 158190007601 D-loop; other site 158190007602 H-loop/switch region; other site 158190007603 TOBE domain; Region: TOBE_2; pfam08402 158190007604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190007605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190007606 dimer interface [polypeptide binding]; other site 158190007607 phosphorylation site [posttranslational modification] 158190007608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190007609 ATP binding site [chemical binding]; other site 158190007610 Mg2+ binding site [ion binding]; other site 158190007611 G-X-G motif; other site 158190007612 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190007613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190007614 active site 158190007615 phosphorylation site [posttranslational modification] 158190007616 intermolecular recognition site; other site 158190007617 dimerization interface [polypeptide binding]; other site 158190007618 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190007619 DNA binding site [nucleotide binding] 158190007620 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190007621 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 158190007622 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158190007623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007624 dimer interface [polypeptide binding]; other site 158190007625 conserved gate region; other site 158190007626 putative PBP binding loops; other site 158190007627 ABC-ATPase subunit interface; other site 158190007628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007629 dimer interface [polypeptide binding]; other site 158190007630 conserved gate region; other site 158190007631 putative PBP binding loops; other site 158190007632 ABC-ATPase subunit interface; other site 158190007633 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190007634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190007635 Walker A/P-loop; other site 158190007636 ATP binding site [chemical binding]; other site 158190007637 Q-loop/lid; other site 158190007638 ABC transporter signature motif; other site 158190007639 Walker B; other site 158190007640 D-loop; other site 158190007641 H-loop/switch region; other site 158190007642 TOBE domain; Region: TOBE_2; pfam08402 158190007643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190007644 non-specific DNA binding site [nucleotide binding]; other site 158190007645 salt bridge; other site 158190007646 sequence-specific DNA binding site [nucleotide binding]; other site 158190007647 Domain of unknown function (DUF955); Region: DUF955; pfam06114 158190007648 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 158190007649 active site 158190007650 catalytic residues [active] 158190007651 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 158190007652 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190007653 nucleotide binding site [chemical binding]; other site 158190007654 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158190007655 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158190007656 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158190007657 putative active site [active] 158190007658 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 158190007659 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158190007660 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158190007661 substrate binding site [chemical binding]; other site 158190007662 trimer interface [polypeptide binding]; other site 158190007663 Mn binding site [ion binding]; other site 158190007664 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 158190007665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190007666 dimerization interface [polypeptide binding]; other site 158190007667 Histidine kinase; Region: His_kinase; pfam06580 158190007668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190007669 ATP binding site [chemical binding]; other site 158190007670 Mg2+ binding site [ion binding]; other site 158190007671 G-X-G motif; other site 158190007672 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 158190007673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190007674 active site 158190007675 phosphorylation site [posttranslational modification] 158190007676 intermolecular recognition site; other site 158190007677 dimerization interface [polypeptide binding]; other site 158190007678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190007679 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190007680 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190007681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007682 dimer interface [polypeptide binding]; other site 158190007683 conserved gate region; other site 158190007684 putative PBP binding loops; other site 158190007685 ABC-ATPase subunit interface; other site 158190007686 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190007687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190007688 dimer interface [polypeptide binding]; other site 158190007689 conserved gate region; other site 158190007690 putative PBP binding loops; other site 158190007691 ABC-ATPase subunit interface; other site 158190007692 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 158190007693 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 158190007694 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 158190007695 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190007696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190007697 DNA-binding site [nucleotide binding]; DNA binding site 158190007698 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190007699 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190007700 ligand binding site [chemical binding]; other site 158190007701 dimerization interface [polypeptide binding]; other site 158190007702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158190007703 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158190007704 ligand binding site [chemical binding]; other site 158190007705 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190007706 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190007707 Walker A/P-loop; other site 158190007708 ATP binding site [chemical binding]; other site 158190007709 Q-loop/lid; other site 158190007710 ABC transporter signature motif; other site 158190007711 Walker B; other site 158190007712 D-loop; other site 158190007713 H-loop/switch region; other site 158190007714 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190007715 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190007716 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190007717 TM-ABC transporter signature motif; other site 158190007718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190007719 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 158190007720 NAD(P) binding site [chemical binding]; other site 158190007721 active site 158190007722 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 158190007723 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158190007724 TPP-binding site [chemical binding]; other site 158190007725 dimer interface [polypeptide binding]; other site 158190007726 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158190007727 PYR/PP interface [polypeptide binding]; other site 158190007728 dimer interface [polypeptide binding]; other site 158190007729 TPP binding site [chemical binding]; other site 158190007730 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158190007731 ribulokinase; Provisional; Region: PRK04123 158190007732 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158190007733 nucleotide binding site [chemical binding]; other site 158190007734 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 158190007735 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 158190007736 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 158190007737 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 158190007738 DNA binding residues [nucleotide binding] 158190007739 drug binding residues [chemical binding]; other site 158190007740 dimer interface [polypeptide binding]; other site 158190007741 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 158190007742 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 158190007743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190007744 active site 158190007745 Helix-turn-helix domain; Region: HTH_18; pfam12833 158190007746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190007747 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 158190007748 Transposase; Region: DEDD_Tnp_IS110; pfam01548 158190007749 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 158190007750 putative active site [active] 158190007751 putative metal binding site [ion binding]; other site 158190007752 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190007753 Homeobox associated leucine zipper; Region: HALZ; cl02577 158190007754 putative transposase OrfB; Reviewed; Region: PHA02517 158190007755 HTH-like domain; Region: HTH_21; pfam13276 158190007756 Integrase core domain; Region: rve; pfam00665 158190007757 Integrase core domain; Region: rve_2; pfam13333 158190007758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190007759 Walker A motif; other site 158190007760 ATP binding site [chemical binding]; other site 158190007761 Walker B motif; other site 158190007762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 158190007763 Integrase core domain; Region: rve; pfam00665 158190007764 Homeobox associated leucine zipper; Region: HALZ; cl02577 158190007765 putative transposase OrfB; Reviewed; Region: PHA02517 158190007766 HTH-like domain; Region: HTH_21; pfam13276 158190007767 Integrase core domain; Region: rve; pfam00665 158190007768 Integrase core domain; Region: rve_2; pfam13333 158190007769 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190007770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190007771 non-specific DNA binding site [nucleotide binding]; other site 158190007772 salt bridge; other site 158190007773 sequence-specific DNA binding site [nucleotide binding]; other site 158190007774 ParB-like nuclease domain; Region: ParBc; pfam02195 158190007775 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 158190007776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190007777 ATP binding site [chemical binding]; other site 158190007778 putative Mg++ binding site [ion binding]; other site 158190007779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190007780 nucleotide binding region [chemical binding]; other site 158190007781 ATP-binding site [chemical binding]; other site 158190007782 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 158190007783 ParB-like nuclease domain; Region: ParB; smart00470 158190007784 Tetratricopeptide repeat; Region: TPR_12; pfam13424 158190007785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190007786 binding surface 158190007787 TPR motif; other site 158190007788 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 158190007789 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 158190007790 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 158190007791 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 158190007792 active site 158190007793 HIGH motif; other site 158190007794 KMSKS motif; other site 158190007795 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 158190007796 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158190007797 GTPase Era; Reviewed; Region: era; PRK00089 158190007798 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 158190007799 G1 box; other site 158190007800 GTP/Mg2+ binding site [chemical binding]; other site 158190007801 Switch I region; other site 158190007802 G2 box; other site 158190007803 Switch II region; other site 158190007804 G3 box; other site 158190007805 G4 box; other site 158190007806 G5 box; other site 158190007807 KH domain; Region: KH_2; pfam07650 158190007808 G-X-X-G motif; other site 158190007809 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 158190007810 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 158190007811 oligomer interface [polypeptide binding]; other site 158190007812 active site residues [active] 158190007813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190007814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190007815 putative substrate translocation pore; other site 158190007816 HEAT repeats; Region: HEAT_2; pfam13646 158190007817 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 158190007818 putative catalytic site [active] 158190007819 putative metal binding site [ion binding]; other site 158190007820 putative phosphate binding site [ion binding]; other site 158190007821 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 158190007822 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 158190007823 CoA binding domain; Region: CoA_binding; pfam02629 158190007824 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 158190007825 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 158190007826 putative dimer interface [polypeptide binding]; other site 158190007827 [2Fe-2S] cluster binding site [ion binding]; other site 158190007828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190007829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190007830 ATP binding site [chemical binding]; other site 158190007831 Mg2+ binding site [ion binding]; other site 158190007832 G-X-G motif; other site 158190007833 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 158190007834 dimer interface [polypeptide binding]; other site 158190007835 [2Fe-2S] cluster binding site [ion binding]; other site 158190007836 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 158190007837 dimer interface [polypeptide binding]; other site 158190007838 [2Fe-2S] cluster binding site [ion binding]; other site 158190007839 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 158190007840 SLBB domain; Region: SLBB; pfam10531 158190007841 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 158190007842 4Fe-4S binding domain; Region: Fer4; pfam00037 158190007843 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190007844 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 158190007845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 158190007846 catalytic loop [active] 158190007847 iron binding site [ion binding]; other site 158190007848 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 158190007849 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 158190007850 4Fe-4S binding domain; Region: Fer4; pfam00037 158190007851 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158190007852 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 158190007853 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190007854 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190007855 metal binding site [ion binding]; metal-binding site 158190007856 active site 158190007857 I-site; other site 158190007858 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 158190007859 active site 158190007860 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 158190007861 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 158190007862 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 158190007863 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158190007864 active site 158190007865 phosphorylation site [posttranslational modification] 158190007866 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 158190007867 peptidase T; Region: peptidase-T; TIGR01882 158190007868 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 158190007869 metal binding site [ion binding]; metal-binding site 158190007870 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 158190007871 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 158190007872 active site 158190007873 catalytic site [active] 158190007874 endonuclease IV; Provisional; Region: PRK01060 158190007875 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 158190007876 AP (apurinic/apyrimidinic) site pocket; other site 158190007877 DNA interaction; other site 158190007878 Metal-binding active site; metal-binding site 158190007879 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 158190007880 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 158190007881 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 158190007882 Peptidase M16C associated; Region: M16C_assoc; pfam08367 158190007883 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190007884 4Fe-4S binding domain; Region: Fer4; pfam00037 158190007885 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 158190007886 Putative Fe-S cluster; Region: FeS; cl17515 158190007887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 158190007888 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 158190007889 ATP binding site [chemical binding]; other site 158190007890 Mg2+ binding site [ion binding]; other site 158190007891 G-X-G motif; other site 158190007892 DRTGG domain; Region: DRTGG; pfam07085 158190007893 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 158190007894 nucleophile elbow; other site 158190007895 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158190007896 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 158190007897 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158190007898 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158190007899 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 158190007900 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 158190007901 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 158190007902 glycerol kinase; Provisional; Region: glpK; PRK00047 158190007903 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 158190007904 N- and C-terminal domain interface [polypeptide binding]; other site 158190007905 active site 158190007906 MgATP binding site [chemical binding]; other site 158190007907 catalytic site [active] 158190007908 metal binding site [ion binding]; metal-binding site 158190007909 glycerol binding site [chemical binding]; other site 158190007910 homotetramer interface [polypeptide binding]; other site 158190007911 homodimer interface [polypeptide binding]; other site 158190007912 FBP binding site [chemical binding]; other site 158190007913 protein IIAGlc interface [polypeptide binding]; other site 158190007914 Uncharacterized conserved protein [Function unknown]; Region: COG1624 158190007915 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 158190007916 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 158190007917 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 158190007918 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 158190007919 dimerization interface 3.5A [polypeptide binding]; other site 158190007920 active site 158190007921 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 158190007922 Fe-S cluster binding site [ion binding]; other site 158190007923 active site 158190007924 primosome assembly protein PriA; Validated; Region: PRK05580 158190007925 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190007926 ATP binding site [chemical binding]; other site 158190007927 putative Mg++ binding site [ion binding]; other site 158190007928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190007929 ATP-binding site [chemical binding]; other site 158190007930 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 158190007931 active site 158190007932 catalytic residues [active] 158190007933 metal binding site [ion binding]; metal-binding site 158190007934 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 158190007935 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 158190007936 putative active site [active] 158190007937 substrate binding site [chemical binding]; other site 158190007938 putative cosubstrate binding site; other site 158190007939 catalytic site [active] 158190007940 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 158190007941 substrate binding site [chemical binding]; other site 158190007942 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 158190007943 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 158190007944 active site 158190007945 nucleophile elbow; other site 158190007946 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 158190007947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190007948 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 158190007949 Fumarase C-terminus; Region: Fumerase_C; cl00795 158190007950 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 158190007951 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 158190007952 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 158190007953 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 158190007954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190007955 motif II; other site 158190007956 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 158190007957 HIT family signature motif; other site 158190007958 catalytic residue [active] 158190007959 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 158190007960 elongation factor G; Reviewed; Region: PRK12740 158190007961 G1 box; other site 158190007962 putative GEF interaction site [polypeptide binding]; other site 158190007963 GTP/Mg2+ binding site [chemical binding]; other site 158190007964 Switch I region; other site 158190007965 G2 box; other site 158190007966 G3 box; other site 158190007967 Switch II region; other site 158190007968 G4 box; other site 158190007969 G5 box; other site 158190007970 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 158190007971 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 158190007972 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 158190007973 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 158190007974 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 158190007975 lactaldehyde reductase; Region: lactal_redase; TIGR02638 158190007976 active site 158190007977 NAD binding site [chemical binding]; other site 158190007978 metal binding site [ion binding]; metal-binding site 158190007979 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 158190007980 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 158190007981 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 158190007982 PYR/PP interface [polypeptide binding]; other site 158190007983 dimer interface [polypeptide binding]; other site 158190007984 TPP binding site [chemical binding]; other site 158190007985 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158190007986 transketolase; Reviewed; Region: PRK05899 158190007987 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 158190007988 TPP-binding site [chemical binding]; other site 158190007989 dimer interface [polypeptide binding]; other site 158190007990 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 158190007991 active site 158190007992 catalytic residues [active] 158190007993 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 158190007994 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158190007995 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 158190007996 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158190007997 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158190007998 trimer interface [polypeptide binding]; other site 158190007999 substrate binding site [chemical binding]; other site 158190008000 Mn binding site [ion binding]; other site 158190008001 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 158190008002 putative switch regulator; other site 158190008003 non-specific DNA interactions [nucleotide binding]; other site 158190008004 DNA binding site [nucleotide binding] 158190008005 sequence specific DNA binding site [nucleotide binding]; other site 158190008006 putative cAMP binding site [chemical binding]; other site 158190008007 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190008008 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 158190008009 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190008010 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190008011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190008012 dimer interface [polypeptide binding]; other site 158190008013 conserved gate region; other site 158190008014 putative PBP binding loops; other site 158190008015 ABC-ATPase subunit interface; other site 158190008016 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190008017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190008018 dimer interface [polypeptide binding]; other site 158190008019 conserved gate region; other site 158190008020 putative PBP binding loops; other site 158190008021 ABC-ATPase subunit interface; other site 158190008022 alpha-glucosidase; Provisional; Region: PRK10426 158190008023 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 158190008024 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 158190008025 putative active site [active] 158190008026 putative catalytic site [active] 158190008027 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 158190008028 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 158190008029 active site 158190008030 substrate binding site [chemical binding]; other site 158190008031 Mg2+ binding site [ion binding]; other site 158190008032 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190008033 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158190008034 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158190008035 DctM-like transporters; Region: DctM; pfam06808 158190008036 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190008037 mannonate dehydratase; Provisional; Region: PRK03906 158190008038 mannonate dehydratase; Region: uxuA; TIGR00695 158190008039 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158190008040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190008041 DNA-binding site [nucleotide binding]; DNA binding site 158190008042 FCD domain; Region: FCD; pfam07729 158190008043 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 158190008044 FMN binding site [chemical binding]; other site 158190008045 dimer interface [polypeptide binding]; other site 158190008046 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 158190008047 LrgB-like family; Region: LrgB; pfam04172 158190008048 Uncharacterized conserved protein [Function unknown]; Region: COG1284 158190008049 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 158190008050 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 158190008051 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 158190008052 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 158190008053 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 158190008054 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 158190008055 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 158190008056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190008057 DNA-binding site [nucleotide binding]; DNA binding site 158190008058 FCD domain; Region: FCD; pfam07729 158190008059 mannonate dehydratase; Provisional; Region: PRK03906 158190008060 mannonate dehydratase; Region: uxuA; TIGR00695 158190008061 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 158190008062 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 158190008063 active site 158190008064 trimer interface [polypeptide binding]; other site 158190008065 allosteric site; other site 158190008066 active site lid [active] 158190008067 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158190008068 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 158190008069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190008070 Coenzyme A binding pocket [chemical binding]; other site 158190008071 enolase; Provisional; Region: eno; PRK00077 158190008072 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 158190008073 dimer interface [polypeptide binding]; other site 158190008074 metal binding site [ion binding]; metal-binding site 158190008075 substrate binding pocket [chemical binding]; other site 158190008076 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 158190008077 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158190008078 active site 158190008079 nucleotide binding site [chemical binding]; other site 158190008080 HIGH motif; other site 158190008081 KMSKS motif; other site 158190008082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190008083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190008084 active site 158190008085 phosphorylation site [posttranslational modification] 158190008086 intermolecular recognition site; other site 158190008087 dimerization interface [polypeptide binding]; other site 158190008088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190008089 DNA binding site [nucleotide binding] 158190008090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190008091 dimer interface [polypeptide binding]; other site 158190008092 phosphorylation site [posttranslational modification] 158190008093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190008094 ATP binding site [chemical binding]; other site 158190008095 Mg2+ binding site [ion binding]; other site 158190008096 G-X-G motif; other site 158190008097 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 158190008098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190008099 active site 158190008100 phosphorylation site [posttranslational modification] 158190008101 intermolecular recognition site; other site 158190008102 dimerization interface [polypeptide binding]; other site 158190008103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158190008104 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158190008105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 158190008106 citrate lyase subunit gamma; Provisional; Region: PRK13253 158190008107 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 158190008108 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 158190008109 Coenzyme A transferase; Region: CoA_trans; cl17247 158190008110 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 158190008111 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 158190008112 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 158190008113 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 158190008114 putative dimer interface [polypeptide binding]; other site 158190008115 catalytic triad [active] 158190008116 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 158190008117 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190008118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190008119 dimer interface [polypeptide binding]; other site 158190008120 conserved gate region; other site 158190008121 putative PBP binding loops; other site 158190008122 ABC-ATPase subunit interface; other site 158190008123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190008124 dimer interface [polypeptide binding]; other site 158190008125 conserved gate region; other site 158190008126 putative PBP binding loops; other site 158190008127 ABC-ATPase subunit interface; other site 158190008128 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 158190008129 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190008130 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 158190008131 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190008132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190008133 DNA binding site [nucleotide binding] 158190008134 domain linker motif; other site 158190008135 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190008136 dimerization interface [polypeptide binding]; other site 158190008137 ligand binding site [chemical binding]; other site 158190008138 CAAX protease self-immunity; Region: Abi; pfam02517 158190008139 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 158190008140 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 158190008141 Part of AAA domain; Region: AAA_19; pfam13245 158190008142 Family description; Region: UvrD_C_2; pfam13538 158190008143 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 158190008144 Sensory domain found in PocR; Region: PocR; pfam10114 158190008145 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 158190008146 PAS domain; Region: PAS_9; pfam13426 158190008147 PAS fold; Region: PAS_4; pfam08448 158190008148 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190008149 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190008150 metal binding site [ion binding]; metal-binding site 158190008151 active site 158190008152 I-site; other site 158190008153 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 158190008154 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190008155 Zn2+ binding site [ion binding]; other site 158190008156 Mg2+ binding site [ion binding]; other site 158190008157 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 158190008158 L-fucose isomerase; Provisional; Region: fucI; PRK10991 158190008159 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158190008160 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158190008161 trimer interface [polypeptide binding]; other site 158190008162 substrate binding site [chemical binding]; other site 158190008163 Mn binding site [ion binding]; other site 158190008164 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 158190008165 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158190008166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190008167 Helix-turn-helix domain; Region: HTH_18; pfam12833 158190008168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190008169 L-rhamnose isomerase; Provisional; Region: PRK01076 158190008170 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 158190008171 Uncharacterized conserved protein [Function unknown]; Region: COG3347 158190008172 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 158190008173 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 158190008174 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 158190008175 ligand binding site [chemical binding]; other site 158190008176 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190008177 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190008178 Walker A/P-loop; other site 158190008179 ATP binding site [chemical binding]; other site 158190008180 Q-loop/lid; other site 158190008181 ABC transporter signature motif; other site 158190008182 Walker B; other site 158190008183 D-loop; other site 158190008184 H-loop/switch region; other site 158190008185 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190008186 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190008187 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190008188 TM-ABC transporter signature motif; other site 158190008189 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190008190 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190008191 TM-ABC transporter signature motif; other site 158190008192 Domain of unknown function (DUF718); Region: DUF718; pfam05336 158190008193 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158190008194 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 158190008195 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158190008196 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 158190008197 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 158190008198 E3 interaction surface; other site 158190008199 lipoyl attachment site [posttranslational modification]; other site 158190008200 e3 binding domain; Region: E3_binding; pfam02817 158190008201 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 158190008202 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 158190008203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158190008204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158190008205 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 158190008206 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 158190008207 tetramer interface [polypeptide binding]; other site 158190008208 TPP-binding site [chemical binding]; other site 158190008209 heterodimer interface [polypeptide binding]; other site 158190008210 phosphorylation loop region [posttranslational modification] 158190008211 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 158190008212 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 158190008213 PYR/PP interface [polypeptide binding]; other site 158190008214 dimer interface [polypeptide binding]; other site 158190008215 TPP binding site [chemical binding]; other site 158190008216 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 158190008217 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 158190008218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190008219 NAD(P) binding site [chemical binding]; other site 158190008220 active site 158190008221 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 158190008222 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158190008223 putative NAD(P) binding site [chemical binding]; other site 158190008224 catalytic Zn binding site [ion binding]; other site 158190008225 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 158190008226 N- and C-terminal domain interface [polypeptide binding]; other site 158190008227 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 158190008228 active site 158190008229 putative catalytic site [active] 158190008230 metal binding site [ion binding]; metal-binding site 158190008231 ATP binding site [chemical binding]; other site 158190008232 carbohydrate binding site [chemical binding]; other site 158190008233 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158190008234 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 158190008235 putative ligand binding site [chemical binding]; other site 158190008236 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190008237 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190008238 Walker A/P-loop; other site 158190008239 ATP binding site [chemical binding]; other site 158190008240 Q-loop/lid; other site 158190008241 ABC transporter signature motif; other site 158190008242 Walker B; other site 158190008243 D-loop; other site 158190008244 H-loop/switch region; other site 158190008245 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190008246 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190008247 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190008248 TM-ABC transporter signature motif; other site 158190008249 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190008250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190008251 DNA binding site [nucleotide binding] 158190008252 domain linker motif; other site 158190008253 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190008254 ligand binding site [chemical binding]; other site 158190008255 dimerization interface [polypeptide binding]; other site 158190008256 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 158190008257 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158190008258 putative NAD(P) binding site [chemical binding]; other site 158190008259 catalytic Zn binding site [ion binding]; other site 158190008260 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158190008261 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158190008262 active site 158190008263 catalytic tetrad [active] 158190008264 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190008265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190008266 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190008267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190008268 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 158190008269 active site 158190008270 intersubunit interactions; other site 158190008271 catalytic residue [active] 158190008272 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 158190008273 active site 158190008274 catalytic triad [active] 158190008275 oxyanion hole [active] 158190008276 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 158190008277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158190008278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190008279 homodimer interface [polypeptide binding]; other site 158190008280 catalytic residue [active] 158190008281 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158190008282 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190008283 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 158190008284 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 158190008285 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 158190008286 tetramer interface [polypeptide binding]; other site 158190008287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190008288 catalytic residue [active] 158190008289 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 158190008290 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 158190008291 hinge; other site 158190008292 active site 158190008293 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 158190008294 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 158190008295 peptide binding site [polypeptide binding]; other site 158190008296 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 158190008297 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158190008298 Walker A/P-loop; other site 158190008299 ATP binding site [chemical binding]; other site 158190008300 Q-loop/lid; other site 158190008301 ABC transporter signature motif; other site 158190008302 Walker B; other site 158190008303 D-loop; other site 158190008304 H-loop/switch region; other site 158190008305 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158190008306 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 158190008307 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158190008308 Walker A/P-loop; other site 158190008309 ATP binding site [chemical binding]; other site 158190008310 Q-loop/lid; other site 158190008311 ABC transporter signature motif; other site 158190008312 Walker B; other site 158190008313 D-loop; other site 158190008314 H-loop/switch region; other site 158190008315 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158190008316 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 158190008317 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 158190008318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190008319 dimer interface [polypeptide binding]; other site 158190008320 conserved gate region; other site 158190008321 putative PBP binding loops; other site 158190008322 ABC-ATPase subunit interface; other site 158190008323 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 158190008324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190008325 dimer interface [polypeptide binding]; other site 158190008326 conserved gate region; other site 158190008327 putative PBP binding loops; other site 158190008328 ABC-ATPase subunit interface; other site 158190008329 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 158190008330 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 158190008331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190008332 FeS/SAM binding site; other site 158190008333 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 158190008334 Part of AAA domain; Region: AAA_19; pfam13245 158190008335 Family description; Region: UvrD_C_2; pfam13538 158190008336 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158190008337 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 158190008338 23S rRNA interface [nucleotide binding]; other site 158190008339 L3 interface [polypeptide binding]; other site 158190008340 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 158190008341 recombination regulator RecX; Reviewed; Region: recX; PRK00117 158190008342 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 158190008343 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 158190008344 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 158190008345 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 158190008346 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 158190008347 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 158190008348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190008349 catalytic residue [active] 158190008350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 158190008351 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158190008352 catalytic residues [active] 158190008353 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 158190008354 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 158190008355 active site 158190008356 dimer interface [polypeptide binding]; other site 158190008357 A new structural DNA glycosylase; Region: AlkD_like; cd06561 158190008358 active site 158190008359 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 158190008360 fructuronate transporter; Provisional; Region: PRK10034; cl15264 158190008361 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 158190008362 Cation transport protein; Region: TrkH; cl17365 158190008363 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 158190008364 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 158190008365 TrkA-N domain; Region: TrkA_N; pfam02254 158190008366 TrkA-C domain; Region: TrkA_C; pfam02080 158190008367 TrkA-N domain; Region: TrkA_N; pfam02254 158190008368 TrkA-C domain; Region: TrkA_C; pfam02080 158190008369 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 158190008370 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158190008371 metal-binding site [ion binding] 158190008372 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 158190008373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190008374 dimerization interface [polypeptide binding]; other site 158190008375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190008376 dimer interface [polypeptide binding]; other site 158190008377 phosphorylation site [posttranslational modification] 158190008378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190008379 ATP binding site [chemical binding]; other site 158190008380 Mg2+ binding site [ion binding]; other site 158190008381 G-X-G motif; other site 158190008382 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190008383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190008384 active site 158190008385 phosphorylation site [posttranslational modification] 158190008386 intermolecular recognition site; other site 158190008387 dimerization interface [polypeptide binding]; other site 158190008388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190008389 DNA binding site [nucleotide binding] 158190008390 Short C-terminal domain; Region: SHOCT; pfam09851 158190008391 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 158190008392 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190008393 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190008394 Walker A/P-loop; other site 158190008395 ATP binding site [chemical binding]; other site 158190008396 Q-loop/lid; other site 158190008397 ABC transporter signature motif; other site 158190008398 Walker B; other site 158190008399 D-loop; other site 158190008400 H-loop/switch region; other site 158190008401 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190008402 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190008403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190008404 TM-ABC transporter signature motif; other site 158190008405 Domain of unknown function (DUF947); Region: DUF947; pfam06102 158190008406 Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868 158190008407 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190008408 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190008409 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190008410 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190008411 DNA binding site [nucleotide binding] 158190008412 domain linker motif; other site 158190008413 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190008414 dimerization interface [polypeptide binding]; other site 158190008415 ligand binding site [chemical binding]; other site 158190008416 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 158190008417 Domain of unknown function (DUF386); Region: DUF386; cl01047 158190008418 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190008419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190008420 DNA-binding site [nucleotide binding]; DNA binding site 158190008421 FCD domain; Region: FCD; pfam07729 158190008422 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190008423 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158190008424 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158190008425 DctM-like transporters; Region: DctM; pfam06808 158190008426 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190008427 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 158190008428 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 158190008429 inhibitor site; inhibition site 158190008430 active site 158190008431 dimer interface [polypeptide binding]; other site 158190008432 catalytic residue [active] 158190008433 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 158190008434 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190008435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190008436 DNA-binding site [nucleotide binding]; DNA binding site 158190008437 FCD domain; Region: FCD; pfam07729 158190008438 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 158190008439 putative ligand binding pocket/active site [active] 158190008440 putative metal binding site [ion binding]; other site 158190008441 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 158190008442 AMMECR1; Region: AMMECR1; pfam01871 158190008443 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 158190008444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190008445 FeS/SAM binding site; other site 158190008446 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 158190008447 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 158190008448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190008449 Walker A/P-loop; other site 158190008450 ATP binding site [chemical binding]; other site 158190008451 Q-loop/lid; other site 158190008452 ABC transporter signature motif; other site 158190008453 Walker B; other site 158190008454 D-loop; other site 158190008455 H-loop/switch region; other site 158190008456 ABC transporter; Region: ABC_tran_2; pfam12848 158190008457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 158190008458 ABC transporter; Region: ABC_tran_2; pfam12848 158190008459 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 158190008460 AIR carboxylase; Region: AIRC; pfam00731 158190008461 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 158190008462 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 158190008463 ATP binding site [chemical binding]; other site 158190008464 active site 158190008465 substrate binding site [chemical binding]; other site 158190008466 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 158190008467 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 158190008468 active site 158190008469 tetramer interface [polypeptide binding]; other site 158190008470 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158190008471 active site 158190008472 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 158190008473 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 158190008474 dimerization interface [polypeptide binding]; other site 158190008475 putative ATP binding site [chemical binding]; other site 158190008476 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 158190008477 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 158190008478 active site 158190008479 substrate binding site [chemical binding]; other site 158190008480 cosubstrate binding site; other site 158190008481 catalytic site [active] 158190008482 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 158190008483 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 158190008484 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 158190008485 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 158190008486 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 158190008487 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 158190008488 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 158190008489 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 158190008490 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 158190008491 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 158190008492 dimerization interface [polypeptide binding]; other site 158190008493 ATP binding site [chemical binding]; other site 158190008494 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 158190008495 dimerization interface [polypeptide binding]; other site 158190008496 ATP binding site [chemical binding]; other site 158190008497 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 158190008498 putative active site [active] 158190008499 catalytic triad [active] 158190008500 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 158190008501 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 158190008502 putative dimer interface [polypeptide binding]; other site 158190008503 Cupin domain; Region: Cupin_2; pfam07883 158190008504 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 158190008505 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 158190008506 FAD binding pocket [chemical binding]; other site 158190008507 FAD binding motif [chemical binding]; other site 158190008508 phosphate binding motif [ion binding]; other site 158190008509 beta-alpha-beta structure motif; other site 158190008510 NAD binding pocket [chemical binding]; other site 158190008511 Iron coordination center [ion binding]; other site 158190008512 putative oxidoreductase; Provisional; Region: PRK12831 158190008513 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190008514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158190008515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158190008516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 158190008517 active site 158190008518 phosphorylation site [posttranslational modification] 158190008519 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 158190008520 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 158190008521 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 158190008522 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 158190008523 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 158190008524 Walker A/P-loop; other site 158190008525 ATP binding site [chemical binding]; other site 158190008526 Q-loop/lid; other site 158190008527 ABC transporter signature motif; other site 158190008528 Walker B; other site 158190008529 D-loop; other site 158190008530 H-loop/switch region; other site 158190008531 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 158190008532 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 158190008533 putative substrate binding site [chemical binding]; other site 158190008534 putative ATP binding site [chemical binding]; other site 158190008535 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 158190008536 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 158190008537 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158190008538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190008539 dimer interface [polypeptide binding]; other site 158190008540 conserved gate region; other site 158190008541 putative PBP binding loops; other site 158190008542 ABC-ATPase subunit interface; other site 158190008543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190008544 dimer interface [polypeptide binding]; other site 158190008545 conserved gate region; other site 158190008546 putative PBP binding loops; other site 158190008547 ABC-ATPase subunit interface; other site 158190008548 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190008549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190008550 Walker A/P-loop; other site 158190008551 ATP binding site [chemical binding]; other site 158190008552 Q-loop/lid; other site 158190008553 ABC transporter signature motif; other site 158190008554 Walker B; other site 158190008555 D-loop; other site 158190008556 H-loop/switch region; other site 158190008557 TOBE domain; Region: TOBE_2; pfam08402 158190008558 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 158190008559 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158190008560 putative NAD(P) binding site [chemical binding]; other site 158190008561 catalytic Zn binding site [ion binding]; other site 158190008562 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 158190008563 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 158190008564 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 158190008565 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 158190008566 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 158190008567 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 158190008568 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 158190008569 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 158190008570 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 158190008571 DNA binding residues [nucleotide binding] 158190008572 dimer interface [polypeptide binding]; other site 158190008573 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 158190008574 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 158190008575 DNA protecting protein DprA; Region: dprA; TIGR00732 158190008576 alanyl-tRNA synthetase; Provisional; Region: PRK01584 158190008577 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 158190008578 motif 1; other site 158190008579 active site 158190008580 motif 2; other site 158190008581 motif 3; other site 158190008582 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 158190008583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190008584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190008585 putative substrate translocation pore; other site 158190008586 hypothetical protein; Provisional; Region: PRK10281 158190008587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190008588 S-adenosylmethionine binding site [chemical binding]; other site 158190008589 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 158190008590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190008591 FeS/SAM binding site; other site 158190008592 OPT oligopeptide transporter protein; Region: OPT; cl14607 158190008593 putative oligopeptide transporter, OPT family; Region: TIGR00733 158190008594 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 158190008595 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 158190008596 HflX GTPase family; Region: HflX; cd01878 158190008597 G1 box; other site 158190008598 GTP/Mg2+ binding site [chemical binding]; other site 158190008599 Switch I region; other site 158190008600 G2 box; other site 158190008601 G3 box; other site 158190008602 Switch II region; other site 158190008603 G4 box; other site 158190008604 G5 box; other site 158190008605 GTP-binding protein YchF; Reviewed; Region: PRK09601 158190008606 YchF GTPase; Region: YchF; cd01900 158190008607 G1 box; other site 158190008608 GTP/Mg2+ binding site [chemical binding]; other site 158190008609 Switch I region; other site 158190008610 G2 box; other site 158190008611 Switch II region; other site 158190008612 G3 box; other site 158190008613 G4 box; other site 158190008614 G5 box; other site 158190008615 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 158190008616 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 158190008617 B12 binding site [chemical binding]; other site 158190008618 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 158190008619 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190008620 FeS/SAM binding site; other site 158190008621 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 158190008622 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 158190008623 active site 158190008624 interdomain interaction site; other site 158190008625 putative metal-binding site [ion binding]; other site 158190008626 nucleotide binding site [chemical binding]; other site 158190008627 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 158190008628 domain I; other site 158190008629 DNA binding groove [nucleotide binding] 158190008630 phosphate binding site [ion binding]; other site 158190008631 domain II; other site 158190008632 domain III; other site 158190008633 nucleotide binding site [chemical binding]; other site 158190008634 catalytic site [active] 158190008635 domain IV; other site 158190008636 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 158190008637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190008638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190008639 SCP-2 sterol transfer family; Region: SCP2; pfam02036 158190008640 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 158190008641 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 158190008642 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 158190008643 active site 158190008644 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 158190008645 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 158190008646 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 158190008647 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 158190008648 RibD C-terminal domain; Region: RibD_C; cl17279 158190008649 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 158190008650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190008651 dimerization interface [polypeptide binding]; other site 158190008652 putative Zn2+ binding site [ion binding]; other site 158190008653 putative DNA binding site [nucleotide binding]; other site 158190008654 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 158190008655 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 158190008656 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 158190008657 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 158190008658 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 158190008659 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 158190008660 putative ligand binding site [chemical binding]; other site 158190008661 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190008662 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 158190008663 TM-ABC transporter signature motif; other site 158190008664 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190008665 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 158190008666 TM-ABC transporter signature motif; other site 158190008667 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 158190008668 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 158190008669 Walker A/P-loop; other site 158190008670 ATP binding site [chemical binding]; other site 158190008671 Q-loop/lid; other site 158190008672 ABC transporter signature motif; other site 158190008673 Walker B; other site 158190008674 D-loop; other site 158190008675 H-loop/switch region; other site 158190008676 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 158190008677 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 158190008678 Walker A/P-loop; other site 158190008679 ATP binding site [chemical binding]; other site 158190008680 Q-loop/lid; other site 158190008681 ABC transporter signature motif; other site 158190008682 Walker B; other site 158190008683 D-loop; other site 158190008684 H-loop/switch region; other site 158190008685 FOG: CBS domain [General function prediction only]; Region: COG0517 158190008686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 158190008687 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 158190008688 Smr domain; Region: Smr; pfam01713 158190008689 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 158190008690 rRNA binding site [nucleotide binding]; other site 158190008691 predicted 30S ribosome binding site; other site 158190008692 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 158190008693 Na2 binding site [ion binding]; other site 158190008694 putative substrate binding site 1 [chemical binding]; other site 158190008695 Na binding site 1 [ion binding]; other site 158190008696 putative substrate binding site 2 [chemical binding]; other site 158190008697 serine hydroxymethyltransferase; Provisional; Region: PRK13580 158190008698 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 158190008699 dimer interface [polypeptide binding]; other site 158190008700 active site 158190008701 glycine-pyridoxal phosphate binding site [chemical binding]; other site 158190008702 folate binding site [chemical binding]; other site 158190008703 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 158190008704 lipoyl attachment site [posttranslational modification]; other site 158190008705 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 158190008706 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 158190008707 tetramer interface [polypeptide binding]; other site 158190008708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190008709 catalytic residue [active] 158190008710 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 158190008711 tetramer interface [polypeptide binding]; other site 158190008712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190008713 catalytic residue [active] 158190008714 phenylhydantoinase; Validated; Region: PRK08323 158190008715 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190008716 active site 158190008717 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 158190008718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190008719 active site 158190008720 motif I; other site 158190008721 motif II; other site 158190008722 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 158190008723 active site 158190008724 catalytic motif [active] 158190008725 Zn binding site [ion binding]; other site 158190008726 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 158190008727 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 158190008728 putative active site [active] 158190008729 catalytic site [active] 158190008730 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 158190008731 putative active site [active] 158190008732 catalytic site [active] 158190008733 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 158190008734 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 158190008735 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 158190008736 DRTGG domain; Region: DRTGG; pfam07085 158190008737 DHH family; Region: DHH; pfam01368 158190008738 DHHA2 domain; Region: DHHA2; pfam02833 158190008739 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 158190008740 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190008741 Zn2+ binding site [ion binding]; other site 158190008742 Mg2+ binding site [ion binding]; other site 158190008743 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 158190008744 synthetase active site [active] 158190008745 NTP binding site [chemical binding]; other site 158190008746 metal binding site [ion binding]; metal-binding site 158190008747 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 158190008748 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 158190008749 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 158190008750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190008751 S-adenosylmethionine binding site [chemical binding]; other site 158190008752 peptide chain release factor 1; Validated; Region: prfA; PRK00591 158190008753 This domain is found in peptide chain release factors; Region: PCRF; smart00937 158190008754 RF-1 domain; Region: RF-1; pfam00472 158190008755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190008756 MFS/sugar transport protein; Region: MFS_2; pfam13347 158190008757 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 158190008758 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190008759 non-specific DNA binding site [nucleotide binding]; other site 158190008760 salt bridge; other site 158190008761 sequence-specific DNA binding site [nucleotide binding]; other site 158190008762 Cupin domain; Region: Cupin_2; pfam07883 158190008763 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 158190008764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 158190008765 NAD(P) binding site [chemical binding]; other site 158190008766 active site 158190008767 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 158190008768 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 158190008769 substrate-cofactor binding pocket; other site 158190008770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190008771 catalytic residue [active] 158190008772 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 158190008773 Coenzyme A binding pocket [chemical binding]; other site 158190008774 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 158190008775 exonuclease I; Provisional; Region: sbcB; PRK11779 158190008776 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 158190008777 active site 158190008778 catalytic site [active] 158190008779 substrate binding site [chemical binding]; other site 158190008780 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 158190008781 Hexokinase [Carbohydrate transport and metabolism]; Region: COG5026 158190008782 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190008783 nucleotide binding site [chemical binding]; other site 158190008784 Hexokinase; Region: Hexokinase_2; pfam03727 158190008785 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190008786 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190008787 DNA binding site [nucleotide binding] 158190008788 domain linker motif; other site 158190008789 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190008790 dimerization interface [polypeptide binding]; other site 158190008791 ligand binding site [chemical binding]; other site 158190008792 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190008793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190008794 dimer interface [polypeptide binding]; other site 158190008795 conserved gate region; other site 158190008796 ABC-ATPase subunit interface; other site 158190008797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190008798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 158190008799 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190008800 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190008801 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190008802 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 158190008803 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 158190008804 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 158190008805 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158190008806 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 158190008807 additional DNA contacts [nucleotide binding]; other site 158190008808 mismatch recognition site; other site 158190008809 active site 158190008810 zinc binding site [ion binding]; other site 158190008811 DNA intercalation site [nucleotide binding]; other site 158190008812 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 158190008813 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 158190008814 active site 158190008815 substrate binding site [chemical binding]; other site 158190008816 metal binding site [ion binding]; metal-binding site 158190008817 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 158190008818 substrate binding site [chemical binding]; other site 158190008819 ATP binding site [chemical binding]; other site 158190008820 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 158190008821 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 158190008822 active site 158190008823 nucleophile elbow; other site 158190008824 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 158190008825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190008826 FeS/SAM binding site; other site 158190008827 flavodoxin; Provisional; Region: PRK06242 158190008828 AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253 158190008829 nucleotide binding site [chemical binding]; other site 158190008830 homodimeric interface [polypeptide binding]; other site 158190008831 uridine monophosphate binding site [chemical binding]; other site 158190008832 Predicted transcriptional regulators [Transcription]; Region: COG1695 158190008833 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 158190008834 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 158190008835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158190008836 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190008837 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 158190008838 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190008839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190008840 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 158190008841 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 158190008842 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 158190008843 active site 158190008844 HIGH motif; other site 158190008845 dimer interface [polypeptide binding]; other site 158190008846 KMSKS motif; other site 158190008847 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 158190008848 RNA binding surface [nucleotide binding]; other site 158190008849 Mor transcription activator family; Region: Mor; cl02360 158190008850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190008851 S-adenosylmethionine binding site [chemical binding]; other site 158190008852 YcxB-like protein; Region: YcxB; pfam14317 158190008853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190008854 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190008855 dimerization interface [polypeptide binding]; other site 158190008856 Histidine kinase; Region: His_kinase; pfam06580 158190008857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190008858 ATP binding site [chemical binding]; other site 158190008859 Mg2+ binding site [ion binding]; other site 158190008860 G-X-G motif; other site 158190008861 Response regulator receiver domain; Region: Response_reg; pfam00072 158190008862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190008863 active site 158190008864 phosphorylation site [posttranslational modification] 158190008865 intermolecular recognition site; other site 158190008866 dimerization interface [polypeptide binding]; other site 158190008867 Helix-turn-helix domain; Region: HTH_18; pfam12833 158190008868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190008869 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190008870 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158190008871 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190008872 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158190008873 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 158190008874 DctM-like transporters; Region: DctM; pfam06808 158190008875 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190008876 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190008877 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190008878 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190008879 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190008880 Walker A/P-loop; other site 158190008881 ATP binding site [chemical binding]; other site 158190008882 Q-loop/lid; other site 158190008883 ABC transporter signature motif; other site 158190008884 Walker B; other site 158190008885 D-loop; other site 158190008886 H-loop/switch region; other site 158190008887 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190008888 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190008889 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190008890 TM-ABC transporter signature motif; other site 158190008891 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190008892 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190008893 TM-ABC transporter signature motif; other site 158190008894 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 158190008895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190008896 active site 158190008897 phosphorylation site [posttranslational modification] 158190008898 intermolecular recognition site; other site 158190008899 dimerization interface [polypeptide binding]; other site 158190008900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190008901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190008902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190008903 dimerization interface [polypeptide binding]; other site 158190008904 Histidine kinase; Region: His_kinase; pfam06580 158190008905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190008906 ATP binding site [chemical binding]; other site 158190008907 Mg2+ binding site [ion binding]; other site 158190008908 G-X-G motif; other site 158190008909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158190008910 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190008911 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 158190008912 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158190008913 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 158190008914 catalytic residues [active] 158190008915 catalytic nucleophile [active] 158190008916 Recombinase; Region: Recombinase; pfam07508 158190008917 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158190008918 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 158190008919 catalytic residues [active] 158190008920 catalytic nucleophile [active] 158190008921 Recombinase; Region: Recombinase; pfam07508 158190008922 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 158190008923 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 158190008924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190008925 dimerization interface [polypeptide binding]; other site 158190008926 putative DNA binding site [nucleotide binding]; other site 158190008927 putative Zn2+ binding site [ion binding]; other site 158190008928 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 158190008929 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158190008930 metal-binding site [ion binding] 158190008931 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158190008932 Soluble P-type ATPase [General function prediction only]; Region: COG4087 158190008933 Cation efflux family; Region: Cation_efflux; cl00316 158190008934 HflK protein; Region: hflK; TIGR01933 158190008935 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 158190008936 HflC protein; Region: hflC; TIGR01932 158190008937 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 158190008938 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 158190008939 HflK protein; Region: hflK; TIGR01933 158190008940 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 158190008941 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 158190008942 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190008943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190008944 active site 158190008945 phosphorylation site [posttranslational modification] 158190008946 intermolecular recognition site; other site 158190008947 dimerization interface [polypeptide binding]; other site 158190008948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190008949 DNA binding site [nucleotide binding] 158190008950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190008951 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190008952 dimerization interface [polypeptide binding]; other site 158190008953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190008954 dimer interface [polypeptide binding]; other site 158190008955 phosphorylation site [posttranslational modification] 158190008956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190008957 ATP binding site [chemical binding]; other site 158190008958 Mg2+ binding site [ion binding]; other site 158190008959 G-X-G motif; other site 158190008960 radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115 158190008961 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 158190008962 Phage-related minor tail protein [Function unknown]; Region: COG5280 158190008963 Phage-related protein [Function unknown]; Region: COG5412 158190008964 Head fiber protein; Region: Phage_head_fibr; pfam11133 158190008965 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 158190008966 Phage capsid family; Region: Phage_capsid; pfam05065 158190008967 Clp protease; Region: CLP_protease; pfam00574 158190008968 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 158190008969 oligomer interface [polypeptide binding]; other site 158190008970 active site residues [active] 158190008971 Phage-related protein [Function unknown]; Region: COG4695 158190008972 Phage portal protein; Region: Phage_portal; pfam04860 158190008973 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 158190008974 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 158190008975 putative active site pocket [active] 158190008976 dimerization interface [polypeptide binding]; other site 158190008977 putative catalytic residue [active] 158190008978 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 158190008979 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 158190008980 ParB-like nuclease domain; Region: ParB; smart00470 158190008981 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 158190008982 DNA methylase; Region: N6_N4_Mtase; pfam01555 158190008983 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 158190008984 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 158190008985 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 158190008986 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 158190008987 Phage terminase, small subunit; Region: Terminase_4; cl01525 158190008988 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 158190008989 active site 158190008990 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 158190008991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190008992 ATP binding site [chemical binding]; other site 158190008993 putative Mg++ binding site [ion binding]; other site 158190008994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190008995 nucleotide binding region [chemical binding]; other site 158190008996 ATP-binding site [chemical binding]; other site 158190008997 VRR-NUC domain; Region: VRR_NUC; pfam08774 158190008998 Virulence-associated protein E; Region: VirE; pfam05272 158190008999 AntA/AntB antirepressor; Region: AntA; cl01430 158190009000 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 158190009001 DNA binding site [nucleotide binding] 158190009002 active site 158190009003 catalytic site [active] 158190009004 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 158190009005 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 158190009006 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 158190009007 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 158190009008 Domain of unknown function (DUF955); Region: DUF955; cl01076 158190009009 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 158190009010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 158190009011 non-specific DNA binding site [nucleotide binding]; other site 158190009012 salt bridge; other site 158190009013 sequence-specific DNA binding site [nucleotide binding]; other site 158190009014 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 158190009015 putative active site [active] 158190009016 catalytic site [active] 158190009017 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 158190009018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190009019 ATP binding site [chemical binding]; other site 158190009020 putative Mg++ binding site [ion binding]; other site 158190009021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190009022 nucleotide binding region [chemical binding]; other site 158190009023 ATP-binding site [chemical binding]; other site 158190009024 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 158190009025 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 158190009026 DNA methylase; Region: N6_N4_Mtase; pfam01555 158190009027 DNA methylase; Region: N6_N4_Mtase; pfam01555 158190009028 Restriction endonuclease [Defense mechanisms]; Region: COG3587 158190009029 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 158190009030 GIY-YIG motif/motif A; other site 158190009031 putative active site [active] 158190009032 putative metal binding site [ion binding]; other site 158190009033 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 158190009034 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158190009035 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 158190009036 catalytic residues [active] 158190009037 catalytic nucleophile [active] 158190009038 Recombinase; Region: Recombinase; pfam07508 158190009039 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 158190009040 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 158190009041 lipoprotein signal peptidase; Provisional; Region: PRK14787 158190009042 Heavy-metal-associated domain; Region: HMA; pfam00403 158190009043 metal-binding site [ion binding] 158190009044 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158190009045 metal-binding site [ion binding] 158190009046 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 158190009047 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 158190009048 metal-binding site [ion binding] 158190009049 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 158190009050 Soluble P-type ATPase [General function prediction only]; Region: COG4087 158190009051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 158190009052 dimerization interface [polypeptide binding]; other site 158190009053 putative DNA binding site [nucleotide binding]; other site 158190009054 putative Zn2+ binding site [ion binding]; other site 158190009055 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 158190009056 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 158190009057 catalytic residues [active] 158190009058 catalytic nucleophile [active] 158190009059 Recombinase; Region: Recombinase; pfam07508 158190009060 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 158190009061 Recombinase; Region: Recombinase; pfam07508 158190009062 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 158190009063 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 158190009064 dimer interface [polypeptide binding]; other site 158190009065 ssDNA binding site [nucleotide binding]; other site 158190009066 tetramer (dimer of dimers) interface [polypeptide binding]; other site 158190009067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190009068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190009069 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 158190009070 Chloramphenicol acetyltransferase; Region: CAT; cl02008 158190009071 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 158190009072 active site flap/lid [active] 158190009073 nucleophilic elbow; other site 158190009074 catalytic triad [active] 158190009075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190009076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158190009077 Coenzyme A binding pocket [chemical binding]; other site 158190009078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190009079 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190009080 dimerization interface [polypeptide binding]; other site 158190009081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190009082 dimer interface [polypeptide binding]; other site 158190009083 phosphorylation site [posttranslational modification] 158190009084 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 158190009085 ATP binding site [chemical binding]; other site 158190009086 Mg2+ binding site [ion binding]; other site 158190009087 G-X-G motif; other site 158190009088 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190009089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190009090 active site 158190009091 phosphorylation site [posttranslational modification] 158190009092 intermolecular recognition site; other site 158190009093 dimerization interface [polypeptide binding]; other site 158190009094 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190009095 DNA binding site [nucleotide binding] 158190009096 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 158190009097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 158190009098 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 158190009099 putative ADP-binding pocket [chemical binding]; other site 158190009100 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 158190009101 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 158190009102 Uncharacterized conserved protein [Function unknown]; Region: COG0398 158190009103 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 158190009104 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190009105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190009106 dimer interface [polypeptide binding]; other site 158190009107 phosphorylation site [posttranslational modification] 158190009108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190009109 ATP binding site [chemical binding]; other site 158190009110 Mg2+ binding site [ion binding]; other site 158190009111 G-X-G motif; other site 158190009112 Response regulator receiver domain; Region: Response_reg; pfam00072 158190009113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190009114 active site 158190009115 phosphorylation site [posttranslational modification] 158190009116 intermolecular recognition site; other site 158190009117 dimerization interface [polypeptide binding]; other site 158190009118 Response regulator receiver domain; Region: Response_reg; pfam00072 158190009119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190009120 active site 158190009121 phosphorylation site [posttranslational modification] 158190009122 intermolecular recognition site; other site 158190009123 dimerization interface [polypeptide binding]; other site 158190009124 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 158190009125 putative binding surface; other site 158190009126 active site 158190009127 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 158190009128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190009129 active site 158190009130 phosphorylation site [posttranslational modification] 158190009131 intermolecular recognition site; other site 158190009132 dimerization interface [polypeptide binding]; other site 158190009133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190009134 Zn2+ binding site [ion binding]; other site 158190009135 Mg2+ binding site [ion binding]; other site 158190009136 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 158190009137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190009138 active site 158190009139 phosphorylation site [posttranslational modification] 158190009140 intermolecular recognition site; other site 158190009141 dimerization interface [polypeptide binding]; other site 158190009142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190009143 Zn2+ binding site [ion binding]; other site 158190009144 Mg2+ binding site [ion binding]; other site 158190009145 Mor transcription activator family; Region: Mor; cl02360 158190009146 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 158190009147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190009148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190009149 ATP binding site [chemical binding]; other site 158190009150 G-X-G motif; other site 158190009151 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 158190009152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190009153 active site 158190009154 phosphorylation site [posttranslational modification] 158190009155 intermolecular recognition site; other site 158190009156 dimerization interface [polypeptide binding]; other site 158190009157 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 158190009158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190009159 active site 158190009160 phosphorylation site [posttranslational modification] 158190009161 intermolecular recognition site; other site 158190009162 dimerization interface [polypeptide binding]; other site 158190009163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190009164 Zn2+ binding site [ion binding]; other site 158190009165 Mg2+ binding site [ion binding]; other site 158190009166 GTPase RsgA; Reviewed; Region: PRK01889 158190009167 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 158190009168 GTPase/Zn-binding domain interface [polypeptide binding]; other site 158190009169 GTP/Mg2+ binding site [chemical binding]; other site 158190009170 G4 box; other site 158190009171 G5 box; other site 158190009172 G1 box; other site 158190009173 Switch I region; other site 158190009174 G2 box; other site 158190009175 G3 box; other site 158190009176 Switch II region; other site 158190009177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190009178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190009179 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 158190009180 HlyD family secretion protein; Region: HlyD_3; pfam13437 158190009181 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158190009182 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158190009183 Walker A/P-loop; other site 158190009184 ATP binding site [chemical binding]; other site 158190009185 Q-loop/lid; other site 158190009186 ABC transporter signature motif; other site 158190009187 Walker B; other site 158190009188 D-loop; other site 158190009189 H-loop/switch region; other site 158190009190 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158190009191 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 158190009192 Walker A/P-loop; other site 158190009193 ATP binding site [chemical binding]; other site 158190009194 Q-loop/lid; other site 158190009195 ABC transporter signature motif; other site 158190009196 Walker B; other site 158190009197 D-loop; other site 158190009198 H-loop/switch region; other site 158190009199 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 158190009200 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 158190009201 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 158190009202 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 158190009203 Lysine efflux permease [General function prediction only]; Region: COG1279 158190009204 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 158190009205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 158190009206 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 158190009207 dimerization interface [polypeptide binding]; other site 158190009208 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 158190009209 Domain of unknown function DUF302; Region: DUF302; cl01364 158190009210 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 158190009211 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 158190009212 catalytic residues [active] 158190009213 argininosuccinate lyase; Provisional; Region: PRK00855 158190009214 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 158190009215 active sites [active] 158190009216 tetramer interface [polypeptide binding]; other site 158190009217 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 158190009218 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 158190009219 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 158190009220 PhoU domain; Region: PhoU; pfam01895 158190009221 PhoU domain; Region: PhoU; pfam01895 158190009222 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 158190009223 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 158190009224 Walker A/P-loop; other site 158190009225 ATP binding site [chemical binding]; other site 158190009226 Q-loop/lid; other site 158190009227 ABC transporter signature motif; other site 158190009228 Walker B; other site 158190009229 D-loop; other site 158190009230 H-loop/switch region; other site 158190009231 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158190009232 FtsX-like permease family; Region: FtsX; pfam02687 158190009233 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 158190009234 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 158190009235 FtsX-like permease family; Region: FtsX; pfam02687 158190009236 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 158190009237 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 158190009238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 158190009239 active site 158190009240 phosphorylation site [posttranslational modification] 158190009241 intermolecular recognition site; other site 158190009242 dimerization interface [polypeptide binding]; other site 158190009243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 158190009244 DNA binding site [nucleotide binding] 158190009245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 158190009246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 158190009247 dimerization interface [polypeptide binding]; other site 158190009248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 158190009249 dimer interface [polypeptide binding]; other site 158190009250 phosphorylation site [posttranslational modification] 158190009251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 158190009252 ATP binding site [chemical binding]; other site 158190009253 Mg2+ binding site [ion binding]; other site 158190009254 G-X-G motif; other site 158190009255 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 158190009256 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 158190009257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158190009258 active site 158190009259 aspartate aminotransferase; Provisional; Region: PRK07568 158190009260 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158190009261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190009262 homodimer interface [polypeptide binding]; other site 158190009263 catalytic residue [active] 158190009264 arginine decarboxylase; Provisional; Region: PRK05354 158190009265 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 158190009266 dimer interface [polypeptide binding]; other site 158190009267 active site 158190009268 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158190009269 catalytic residues [active] 158190009270 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 158190009271 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 158190009272 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 158190009273 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 158190009274 dimer interface [polypeptide binding]; other site 158190009275 active site 158190009276 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 158190009277 catalytic residues [active] 158190009278 substrate binding site [chemical binding]; other site 158190009279 agmatinase; Region: agmatinase; TIGR01230 158190009280 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 158190009281 putative active site [active] 158190009282 Mn binding site [ion binding]; other site 158190009283 Uncharacterized conserved protein [Function unknown]; Region: COG0432 158190009284 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 158190009285 EamA-like transporter family; Region: EamA; pfam00892 158190009286 EamA-like transporter family; Region: EamA; pfam00892 158190009287 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 158190009288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 158190009289 FeS/SAM binding site; other site 158190009290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190009291 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 158190009292 putative substrate translocation pore; other site 158190009293 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 158190009294 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 158190009295 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 158190009296 active site 158190009297 dimerization interface [polypeptide binding]; other site 158190009298 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 158190009299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190009300 motif II; other site 158190009301 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 158190009302 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 158190009303 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 158190009304 homotrimer interaction site [polypeptide binding]; other site 158190009305 putative active site [active] 158190009306 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 158190009307 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 158190009308 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 158190009309 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 158190009310 putative deacylase active site [active] 158190009311 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190009312 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190009313 TM-ABC transporter signature motif; other site 158190009314 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190009315 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 158190009316 TM-ABC transporter signature motif; other site 158190009317 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 158190009318 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190009319 Walker A/P-loop; other site 158190009320 ATP binding site [chemical binding]; other site 158190009321 Q-loop/lid; other site 158190009322 ABC transporter signature motif; other site 158190009323 Walker B; other site 158190009324 D-loop; other site 158190009325 H-loop/switch region; other site 158190009326 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190009327 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 158190009328 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 158190009329 putative ligand binding site [chemical binding]; other site 158190009330 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 158190009331 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 158190009332 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 158190009333 Chain length determinant protein; Region: Wzz; pfam02706 158190009334 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 158190009335 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 158190009336 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158190009337 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 158190009338 ParA/MinD ATPase like; Region: ParA; pfam10609 158190009339 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376 158190009340 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 158190009341 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 158190009342 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 158190009343 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 158190009344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 158190009345 active site 158190009346 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158190009347 phosphate binding site [ion binding]; other site 158190009348 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158190009349 phosphate binding site [ion binding]; other site 158190009350 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 158190009351 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 158190009352 FAD binding pocket [chemical binding]; other site 158190009353 conserved FAD binding motif [chemical binding]; other site 158190009354 phosphate binding motif [ion binding]; other site 158190009355 beta-alpha-beta structure motif; other site 158190009356 NAD binding pocket [chemical binding]; other site 158190009357 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 158190009358 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190009359 active site 158190009360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 158190009361 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 158190009362 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 158190009363 Cl binding site [ion binding]; other site 158190009364 oligomer interface [polypeptide binding]; other site 158190009365 Flagellin N-methylase; Region: FliB; pfam03692 158190009366 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 158190009367 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 158190009368 putative RNA binding site [nucleotide binding]; other site 158190009369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190009370 S-adenosylmethionine binding site [chemical binding]; other site 158190009371 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 158190009372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190009373 motif II; other site 158190009374 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 158190009375 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 158190009376 active site 158190009377 substrate binding site [chemical binding]; other site 158190009378 metal binding site [ion binding]; metal-binding site 158190009379 Competence protein; Region: Competence; pfam03772 158190009380 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 158190009381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190009382 S-adenosylmethionine binding site [chemical binding]; other site 158190009383 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190009384 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 158190009385 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 158190009386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 158190009387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 158190009388 arogenate dehydrogenase; Region: PLN02256 158190009389 Prephenate dehydrogenase; Region: PDH; pfam02153 158190009390 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 158190009391 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 158190009392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 158190009393 FeS/SAM binding site; other site 158190009394 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 158190009395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 158190009396 serine O-acetyltransferase; Region: cysE; TIGR01172 158190009397 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 158190009398 trimer interface [polypeptide binding]; other site 158190009399 active site 158190009400 substrate binding site [chemical binding]; other site 158190009401 CoA binding site [chemical binding]; other site 158190009402 BioY family; Region: BioY; pfam02632 158190009403 Biotin operon repressor [Transcription]; Region: BirA; COG1654 158190009404 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 158190009405 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 158190009406 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 158190009407 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 158190009408 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 158190009409 KMSK motif region; other site 158190009410 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 158190009411 tRNA binding surface [nucleotide binding]; other site 158190009412 anticodon binding site; other site 158190009413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190009414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190009415 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 158190009416 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 158190009417 GTPase CgtA; Reviewed; Region: obgE; PRK12299 158190009418 GTP1/OBG; Region: GTP1_OBG; pfam01018 158190009419 Obg GTPase; Region: Obg; cd01898 158190009420 G1 box; other site 158190009421 GTP/Mg2+ binding site [chemical binding]; other site 158190009422 Switch I region; other site 158190009423 G2 box; other site 158190009424 G3 box; other site 158190009425 Switch II region; other site 158190009426 G4 box; other site 158190009427 G5 box; other site 158190009428 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 158190009429 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 158190009430 active site 158190009431 (T/H)XGH motif; other site 158190009432 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190009433 Zn2+ binding site [ion binding]; other site 158190009434 Mg2+ binding site [ion binding]; other site 158190009435 Oligomerisation domain; Region: Oligomerisation; pfam02410 158190009436 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190009437 DNA binding site [nucleotide binding] 158190009438 domain linker motif; other site 158190009439 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158190009440 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190009441 ligand binding site [chemical binding]; other site 158190009442 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190009443 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190009444 TM-ABC transporter signature motif; other site 158190009445 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190009446 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190009447 Walker A/P-loop; other site 158190009448 ATP binding site [chemical binding]; other site 158190009449 Q-loop/lid; other site 158190009450 ABC transporter signature motif; other site 158190009451 Walker B; other site 158190009452 D-loop; other site 158190009453 H-loop/switch region; other site 158190009454 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190009455 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 158190009456 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 158190009457 putative ligand binding site [chemical binding]; other site 158190009458 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 158190009459 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 158190009460 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 158190009461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190009462 Walker A/P-loop; other site 158190009463 ATP binding site [chemical binding]; other site 158190009464 Q-loop/lid; other site 158190009465 ABC transporter signature motif; other site 158190009466 Walker B; other site 158190009467 D-loop; other site 158190009468 H-loop/switch region; other site 158190009469 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190009470 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 158190009471 TM-ABC transporter signature motif; other site 158190009472 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 158190009473 zinc binding site [ion binding]; other site 158190009474 putative ligand binding site [chemical binding]; other site 158190009475 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190009476 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190009477 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190009478 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 158190009479 zinc binding site [ion binding]; other site 158190009480 putative ligand binding site [chemical binding]; other site 158190009481 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 158190009482 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 158190009483 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 158190009484 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 158190009485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190009486 AAA domain; Region: AAA_21; pfam13304 158190009487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190009488 Walker A/P-loop; other site 158190009489 Walker A/P-loop; other site 158190009490 ATP binding site [chemical binding]; other site 158190009491 ATP binding site [chemical binding]; other site 158190009492 RloB-like protein; Region: RloB; pfam13707 158190009493 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158190009494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158190009495 DNA binding residues [nucleotide binding] 158190009496 dimerization interface [polypeptide binding]; other site 158190009497 Esterase/lipase [General function prediction only]; Region: COG1647 158190009498 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 158190009499 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 158190009500 nucleophilic elbow; other site 158190009501 catalytic triad; other site 158190009502 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 158190009503 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 158190009504 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 158190009505 active site 158190009506 HIGH motif; other site 158190009507 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 158190009508 active site 158190009509 KMSKS motif; other site 158190009510 glycyl-tRNA synthetase; Provisional; Region: PRK04173 158190009511 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 158190009512 dimer interface [polypeptide binding]; other site 158190009513 motif 1; other site 158190009514 active site 158190009515 motif 2; other site 158190009516 motif 3; other site 158190009517 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 158190009518 anticodon binding site; other site 158190009519 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 158190009520 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 158190009521 active site 158190009522 HIGH motif; other site 158190009523 dimer interface [polypeptide binding]; other site 158190009524 KMSKS motif; other site 158190009525 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 158190009526 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 158190009527 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 158190009528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190009529 dimer interface [polypeptide binding]; other site 158190009530 conserved gate region; other site 158190009531 putative PBP binding loops; other site 158190009532 ABC-ATPase subunit interface; other site 158190009533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190009534 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 158190009535 Walker A/P-loop; other site 158190009536 ATP binding site [chemical binding]; other site 158190009537 Q-loop/lid; other site 158190009538 ABC transporter signature motif; other site 158190009539 Walker B; other site 158190009540 D-loop; other site 158190009541 H-loop/switch region; other site 158190009542 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 158190009543 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 158190009544 non-heme iron binding site [ion binding]; other site 158190009545 dimer interface [polypeptide binding]; other site 158190009546 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 158190009547 non-heme iron binding site [ion binding]; other site 158190009548 glutamate dehydrogenase; Provisional; Region: PRK09414 158190009549 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 158190009550 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 158190009551 NAD(P) binding site [chemical binding]; other site 158190009552 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 158190009553 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 158190009554 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 158190009555 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 158190009556 active site 158190009557 putative substrate binding pocket [chemical binding]; other site 158190009558 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 158190009559 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 158190009560 acyl-activating enzyme (AAE) consensus motif; other site 158190009561 putative AMP binding site [chemical binding]; other site 158190009562 putative active site [active] 158190009563 putative CoA binding site [chemical binding]; other site 158190009564 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 158190009565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190009566 motif II; other site 158190009567 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 158190009568 ligand binding site [chemical binding]; other site 158190009569 active site 158190009570 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 158190009571 SpoVG; Region: SpoVG; cl00915 158190009572 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 158190009573 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 158190009574 5S rRNA interface [nucleotide binding]; other site 158190009575 CTC domain interface [polypeptide binding]; other site 158190009576 L16 interface [polypeptide binding]; other site 158190009577 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 158190009578 putative active site [active] 158190009579 catalytic residue [active] 158190009580 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 158190009581 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 158190009582 Ligand Binding Site [chemical binding]; other site 158190009583 TilS substrate C-terminal domain; Region: TilS_C; smart00977 158190009584 FtsH Extracellular; Region: FtsH_ext; pfam06480 158190009585 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 158190009586 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 158190009587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 158190009588 Walker A motif; other site 158190009589 ATP binding site [chemical binding]; other site 158190009590 Walker B motif; other site 158190009591 arginine finger; other site 158190009592 Peptidase family M41; Region: Peptidase_M41; pfam01434 158190009593 GTP-binding protein LepA; Provisional; Region: PRK05433 158190009594 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 158190009595 G1 box; other site 158190009596 putative GEF interaction site [polypeptide binding]; other site 158190009597 GTP/Mg2+ binding site [chemical binding]; other site 158190009598 Switch I region; other site 158190009599 G2 box; other site 158190009600 G3 box; other site 158190009601 Switch II region; other site 158190009602 G4 box; other site 158190009603 G5 box; other site 158190009604 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 158190009605 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 158190009606 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 158190009607 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 158190009608 active site 158190009609 catalytic residues [active] 158190009610 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 158190009611 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 158190009612 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 158190009613 Sugar specificity; other site 158190009614 Pyrimidine base specificity; other site 158190009615 ATP-binding site [chemical binding]; other site 158190009616 hypothetical protein; Validated; Region: PRK00041 158190009617 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190009618 active site 158190009619 metal binding site [ion binding]; metal-binding site 158190009620 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 158190009621 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 158190009622 active site 158190009623 metal binding site [ion binding]; metal-binding site 158190009624 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 158190009625 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190009626 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 158190009627 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 158190009628 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190009629 ligand binding site [chemical binding]; other site 158190009630 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190009631 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190009632 Walker A/P-loop; other site 158190009633 ATP binding site [chemical binding]; other site 158190009634 Q-loop/lid; other site 158190009635 ABC transporter signature motif; other site 158190009636 Walker B; other site 158190009637 D-loop; other site 158190009638 H-loop/switch region; other site 158190009639 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190009640 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190009641 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190009642 TM-ABC transporter signature motif; other site 158190009643 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190009644 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190009645 TM-ABC transporter signature motif; other site 158190009646 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 158190009647 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 158190009648 NAD binding site [chemical binding]; other site 158190009649 homodimer interface [polypeptide binding]; other site 158190009650 active site 158190009651 substrate binding site [chemical binding]; other site 158190009652 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 158190009653 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 158190009654 active site 158190009655 substrate binding site [chemical binding]; other site 158190009656 metal binding site [ion binding]; metal-binding site 158190009657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 158190009658 S-adenosylmethionine binding site [chemical binding]; other site 158190009659 Spt5 C-terminal nonapeptide repeat binding Spt4; Region: CTD; smart01104 158190009660 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 158190009661 metal binding site 2 [ion binding]; metal-binding site 158190009662 putative DNA binding helix; other site 158190009663 metal binding site 1 [ion binding]; metal-binding site 158190009664 dimer interface [polypeptide binding]; other site 158190009665 structural Zn2+ binding site [ion binding]; other site 158190009666 Rubrerythrin [Energy production and conversion]; Region: COG1592 158190009667 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 158190009668 binuclear metal center [ion binding]; other site 158190009669 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 158190009670 iron binding site [ion binding]; other site 158190009671 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190009672 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 158190009673 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 158190009674 active site 158190009675 HIGH motif; other site 158190009676 nucleotide binding site [chemical binding]; other site 158190009677 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 158190009678 KMSKS motif; other site 158190009679 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 158190009680 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 158190009681 HD supefamily hydrolase [General function prediction only]; Region: COG3294 158190009682 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 158190009683 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 158190009684 putative substrate binding site [chemical binding]; other site 158190009685 putative ATP binding site [chemical binding]; other site 158190009686 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 158190009687 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 158190009688 protein binding site [polypeptide binding]; other site 158190009689 excinuclease ABC subunit B; Provisional; Region: PRK05298 158190009690 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 158190009691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 158190009692 ATP-binding site [chemical binding]; other site 158190009693 ATP binding site [chemical binding]; other site 158190009694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 158190009695 nucleotide binding region [chemical binding]; other site 158190009696 ATP-binding site [chemical binding]; other site 158190009697 Ultra-violet resistance protein B; Region: UvrB; pfam12344 158190009698 UvrB/uvrC motif; Region: UVR; pfam02151 158190009699 Caspase domain; Region: Peptidase_C14; pfam00656 158190009700 Caspase domain; Region: Peptidase_C14; pfam00656 158190009701 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190009702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190009703 Walker A/P-loop; other site 158190009704 ATP binding site [chemical binding]; other site 158190009705 Q-loop/lid; other site 158190009706 ABC transporter signature motif; other site 158190009707 Walker B; other site 158190009708 D-loop; other site 158190009709 H-loop/switch region; other site 158190009710 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 158190009711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190009712 dimer interface [polypeptide binding]; other site 158190009713 conserved gate region; other site 158190009714 putative PBP binding loops; other site 158190009715 ABC-ATPase subunit interface; other site 158190009716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190009717 dimer interface [polypeptide binding]; other site 158190009718 conserved gate region; other site 158190009719 putative PBP binding loops; other site 158190009720 ABC-ATPase subunit interface; other site 158190009721 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190009722 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 158190009723 Uncharacterized conserved protein [Function unknown]; Region: COG0062 158190009724 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 158190009725 putative substrate binding site [chemical binding]; other site 158190009726 putative ATP binding site [chemical binding]; other site 158190009727 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 158190009728 active site 158190009729 8-oxo-dGMP binding site [chemical binding]; other site 158190009730 nudix motif; other site 158190009731 metal binding site [ion binding]; metal-binding site 158190009732 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 158190009733 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190009734 DNA binding site [nucleotide binding] 158190009735 domain linker motif; other site 158190009736 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 158190009737 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 158190009738 ligand binding site [chemical binding]; other site 158190009739 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 158190009740 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 158190009741 putative ligand binding site [chemical binding]; other site 158190009742 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190009743 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190009744 Walker A/P-loop; other site 158190009745 ATP binding site [chemical binding]; other site 158190009746 Q-loop/lid; other site 158190009747 ABC transporter signature motif; other site 158190009748 Walker B; other site 158190009749 D-loop; other site 158190009750 H-loop/switch region; other site 158190009751 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190009752 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190009753 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190009754 TM-ABC transporter signature motif; other site 158190009755 L-arabinose isomerase; Provisional; Region: PRK02929 158190009756 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 158190009757 hexamer (dimer of trimers) interface [polypeptide binding]; other site 158190009758 trimer interface [polypeptide binding]; other site 158190009759 substrate binding site [chemical binding]; other site 158190009760 Mn binding site [ion binding]; other site 158190009761 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 158190009762 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 158190009763 putative N- and C-terminal domain interface [polypeptide binding]; other site 158190009764 putative active site [active] 158190009765 MgATP binding site [chemical binding]; other site 158190009766 catalytic site [active] 158190009767 metal binding site [ion binding]; metal-binding site 158190009768 putative carbohydrate binding site [chemical binding]; other site 158190009769 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 158190009770 PAS domain S-box; Region: sensory_box; TIGR00229 158190009771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 158190009772 putative active site [active] 158190009773 heme pocket [chemical binding]; other site 158190009774 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 158190009775 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 158190009776 metal binding site [ion binding]; metal-binding site 158190009777 active site 158190009778 I-site; other site 158190009779 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 158190009780 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 158190009781 Zn2+ binding site [ion binding]; other site 158190009782 Mg2+ binding site [ion binding]; other site 158190009783 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 158190009784 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 158190009785 ligand binding site; other site 158190009786 oligomer interface; other site 158190009787 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 158190009788 dimer interface [polypeptide binding]; other site 158190009789 N-terminal domain interface [polypeptide binding]; other site 158190009790 sulfate 1 binding site; other site 158190009791 glycogen synthase; Provisional; Region: glgA; PRK00654 158190009792 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 158190009793 ADP-binding pocket [chemical binding]; other site 158190009794 homodimer interface [polypeptide binding]; other site 158190009795 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 158190009796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158190009797 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 158190009798 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 158190009799 Glycoprotease family; Region: Peptidase_M22; pfam00814 158190009800 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 158190009801 Tetratricopeptide repeat; Region: TPR_16; pfam13432 158190009802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 158190009803 binding surface 158190009804 TPR motif; other site 158190009805 TPR repeat; Region: TPR_11; pfam13414 158190009806 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 158190009807 23S rRNA binding site [nucleotide binding]; other site 158190009808 L21 binding site [polypeptide binding]; other site 158190009809 L13 binding site [polypeptide binding]; other site 158190009810 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 158190009811 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 158190009812 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 158190009813 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 158190009814 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 158190009815 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 158190009816 intersubunit interface [polypeptide binding]; other site 158190009817 active site 158190009818 zinc binding site [ion binding]; other site 158190009819 Na+ binding site [ion binding]; other site 158190009820 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 158190009821 active site 158190009822 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 158190009823 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 158190009824 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 158190009825 Walker A/P-loop; other site 158190009826 ATP binding site [chemical binding]; other site 158190009827 Q-loop/lid; other site 158190009828 ABC transporter signature motif; other site 158190009829 Walker B; other site 158190009830 D-loop; other site 158190009831 H-loop/switch region; other site 158190009832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 158190009833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 158190009834 carotene isomerase; Region: carot_isom; TIGR02730 158190009835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158190009836 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 158190009837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158190009838 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 158190009839 AAA domain; Region: AAA_14; pfam13173 158190009840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 158190009841 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 158190009842 active site 158190009843 motif I; other site 158190009844 motif II; other site 158190009845 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 158190009846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 158190009847 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 158190009848 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 158190009849 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 158190009850 homotrimer interaction site [polypeptide binding]; other site 158190009851 putative active site [active] 158190009852 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 158190009853 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 158190009854 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 158190009855 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 158190009856 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 158190009857 predicted active site [active] 158190009858 catalytic triad [active] 158190009859 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 158190009860 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 158190009861 active site 158190009862 multimer interface [polypeptide binding]; other site 158190009863 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 158190009864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190009865 DNA-binding site [nucleotide binding]; DNA binding site 158190009866 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 158190009867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190009868 homodimer interface [polypeptide binding]; other site 158190009869 catalytic residue [active] 158190009870 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 158190009871 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 158190009872 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 158190009873 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 158190009874 PHP domain; Region: PHP; pfam02811 158190009875 active site 158190009876 PHP-associated; Region: PHP_C; pfam13263 158190009877 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158190009878 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 158190009879 active site 158190009880 metal binding site [ion binding]; metal-binding site 158190009881 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 158190009882 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 158190009883 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 158190009884 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 158190009885 oligomer interface [polypeptide binding]; other site 158190009886 active site 158190009887 metal binding site [ion binding]; metal-binding site 158190009888 Creatinine amidohydrolase; Region: Creatininase; pfam02633 158190009889 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 158190009890 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 158190009891 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 158190009892 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158190009893 Walker A/P-loop; other site 158190009894 ATP binding site [chemical binding]; other site 158190009895 Q-loop/lid; other site 158190009896 ABC transporter signature motif; other site 158190009897 Walker B; other site 158190009898 D-loop; other site 158190009899 H-loop/switch region; other site 158190009900 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 158190009901 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 158190009902 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 158190009903 Walker A/P-loop; other site 158190009904 ATP binding site [chemical binding]; other site 158190009905 Q-loop/lid; other site 158190009906 ABC transporter signature motif; other site 158190009907 Walker B; other site 158190009908 D-loop; other site 158190009909 H-loop/switch region; other site 158190009910 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 158190009911 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 158190009912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 158190009913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190009914 dimer interface [polypeptide binding]; other site 158190009915 conserved gate region; other site 158190009916 putative PBP binding loops; other site 158190009917 ABC-ATPase subunit interface; other site 158190009918 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 158190009919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190009920 dimer interface [polypeptide binding]; other site 158190009921 conserved gate region; other site 158190009922 putative PBP binding loops; other site 158190009923 ABC-ATPase subunit interface; other site 158190009924 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cl01007 158190009925 SxDxEG motif; other site 158190009926 active site 158190009927 metal binding site [ion binding]; metal-binding site 158190009928 homopentamer interface [polypeptide binding]; other site 158190009929 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 158190009930 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 158190009931 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 158190009932 putative active site [active] 158190009933 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 158190009934 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 158190009935 active site 158190009936 metal binding site [ion binding]; metal-binding site 158190009937 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 158190009938 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 158190009939 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 158190009940 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 158190009941 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 158190009942 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158190009943 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190009944 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 158190009945 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 158190009946 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158190009947 PEGA domain; Region: PEGA; pfam08308 158190009948 TM2 domain; Region: TM2; cl00984 158190009949 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 158190009950 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 158190009951 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161 158190009952 putative ligand binding site [chemical binding]; other site 158190009953 putative NAD binding site [chemical binding]; other site 158190009954 catalytic site [active] 158190009955 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 158190009956 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 158190009957 Phosphoglycerate kinase; Region: PGK; pfam00162 158190009958 substrate binding site [chemical binding]; other site 158190009959 hinge regions; other site 158190009960 ADP binding site [chemical binding]; other site 158190009961 catalytic site [active] 158190009962 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 158190009963 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 158190009964 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 158190009965 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 158190009966 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 158190009967 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 158190009968 PYR/PP interface [polypeptide binding]; other site 158190009969 dimer interface [polypeptide binding]; other site 158190009970 TPP binding site [chemical binding]; other site 158190009971 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 158190009972 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 158190009973 TPP-binding site [chemical binding]; other site 158190009974 KduI/IolB family; Region: KduI; pfam04962 158190009975 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 158190009976 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 158190009977 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 158190009978 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190009979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190009980 DNA binding site [nucleotide binding] 158190009981 domain linker motif; other site 158190009982 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190009983 dimerization interface [polypeptide binding]; other site 158190009984 ligand binding site [chemical binding]; other site 158190009985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190009986 putative PBP binding loops; other site 158190009987 dimer interface [polypeptide binding]; other site 158190009988 ABC-ATPase subunit interface; other site 158190009989 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190009990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190009991 dimer interface [polypeptide binding]; other site 158190009992 conserved gate region; other site 158190009993 putative PBP binding loops; other site 158190009994 ABC-ATPase subunit interface; other site 158190009995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190009996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190009997 threonine synthase; Validated; Region: PRK06260 158190009998 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 158190009999 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190010000 catalytic residue [active] 158190010001 cysteine synthase; Region: PLN02565 158190010002 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 158190010003 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 158190010004 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190010005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190010006 dimer interface [polypeptide binding]; other site 158190010007 conserved gate region; other site 158190010008 putative PBP binding loops; other site 158190010009 ABC-ATPase subunit interface; other site 158190010010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190010011 dimer interface [polypeptide binding]; other site 158190010012 conserved gate region; other site 158190010013 putative PBP binding loops; other site 158190010014 ABC-ATPase subunit interface; other site 158190010015 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 158190010016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190010017 Walker A/P-loop; other site 158190010018 ATP binding site [chemical binding]; other site 158190010019 Q-loop/lid; other site 158190010020 ABC transporter signature motif; other site 158190010021 Walker B; other site 158190010022 D-loop; other site 158190010023 H-loop/switch region; other site 158190010024 TOBE domain; Region: TOBE_2; pfam08402 158190010025 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 158190010026 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190010027 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158190010028 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 158190010029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158190010030 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 158190010031 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 158190010032 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190010033 active site 158190010034 peptidase; Reviewed; Region: PRK13004 158190010035 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 158190010036 putative metal binding site [ion binding]; other site 158190010037 putative dimer interface [polypeptide binding]; other site 158190010038 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 158190010039 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158190010040 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190010041 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 158190010042 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158190010043 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 158190010044 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 158190010045 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 158190010046 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 158190010047 active site 158190010048 putative substrate binding pocket [chemical binding]; other site 158190010049 putative oxidoreductase; Provisional; Region: PRK09799 158190010050 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 158190010051 putative hypoxanthine oxidase; Provisional; Region: PRK09800 158190010052 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 158190010053 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 158190010054 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 158190010055 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 158190010056 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 158190010057 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 158190010058 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158190010059 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158190010060 active site 158190010061 catalytic tetrad [active] 158190010062 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 158190010063 putative efflux protein, MATE family; Region: matE; TIGR00797 158190010064 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 158190010065 MarR family; Region: MarR_2; pfam12802 158190010066 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 158190010067 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 158190010068 active site 158190010069 metal binding site [ion binding]; metal-binding site 158190010070 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 158190010071 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190010072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190010073 dimer interface [polypeptide binding]; other site 158190010074 conserved gate region; other site 158190010075 putative PBP binding loops; other site 158190010076 ABC-ATPase subunit interface; other site 158190010077 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 158190010078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190010079 dimer interface [polypeptide binding]; other site 158190010080 conserved gate region; other site 158190010081 putative PBP binding loops; other site 158190010082 ABC-ATPase subunit interface; other site 158190010083 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190010084 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 158190010085 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 158190010086 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 158190010087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190010088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 158190010089 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 158190010090 active site 158190010091 catalytic residues [active] 158190010092 flavoprotein, HI0933 family; Region: TIGR00275 158190010093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 158190010094 Transcriptional regulators [Transcription]; Region: FadR; COG2186 158190010095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190010096 DNA-binding site [nucleotide binding]; DNA binding site 158190010097 FCD domain; Region: FCD; pfam07729 158190010098 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 158190010099 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 158190010100 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 158190010101 DctM-like transporters; Region: DctM; pfam06808 158190010102 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 158190010103 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 158190010104 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 158190010105 putative NAD(P) binding site [chemical binding]; other site 158190010106 catalytic Zn binding site [ion binding]; other site 158190010107 structural Zn binding site [ion binding]; other site 158190010108 altronate oxidoreductase; Provisional; Region: PRK03643 158190010109 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 158190010110 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 158190010111 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 158190010112 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 158190010113 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 158190010114 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 158190010115 active site 158190010116 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158190010117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 158190010118 Walker A/P-loop; other site 158190010119 ATP binding site [chemical binding]; other site 158190010120 Q-loop/lid; other site 158190010121 ABC transporter signature motif; other site 158190010122 Walker B; other site 158190010123 D-loop; other site 158190010124 H-loop/switch region; other site 158190010125 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 158190010126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158190010127 ABC-ATPase subunit interface; other site 158190010128 dimer interface [polypeptide binding]; other site 158190010129 putative PBP binding regions; other site 158190010130 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 158190010131 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 158190010132 intersubunit interface [polypeptide binding]; other site 158190010133 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 158190010134 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 158190010135 putative catalytic cysteine [active] 158190010136 gamma-glutamyl kinase; Provisional; Region: PRK05429 158190010137 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 158190010138 nucleotide binding site [chemical binding]; other site 158190010139 homotetrameric interface [polypeptide binding]; other site 158190010140 putative phosphate binding site [ion binding]; other site 158190010141 putative allosteric binding site; other site 158190010142 PUA domain; Region: PUA; pfam01472 158190010143 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 158190010144 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 158190010145 active site 158190010146 metal binding site [ion binding]; metal-binding site 158190010147 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 158190010148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 158190010149 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 158190010150 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 158190010151 Transcriptional regulators [Transcription]; Region: PurR; COG1609 158190010152 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 158190010153 DNA binding site [nucleotide binding] 158190010154 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 158190010155 ligand binding site [chemical binding]; other site 158190010156 dimerization interface [polypeptide binding]; other site 158190010157 L-aspartate oxidase; Provisional; Region: PRK06175 158190010158 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 158190010159 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 158190010160 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 158190010161 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 158190010162 active site 158190010163 seryl-tRNA synthetase; Provisional; Region: PRK05431 158190010164 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 158190010165 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 158190010166 dimer interface [polypeptide binding]; other site 158190010167 active site 158190010168 motif 1; other site 158190010169 motif 2; other site 158190010170 motif 3; other site 158190010171 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 158190010172 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 158190010173 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 158190010174 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 158190010175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 158190010176 DNA binding residues [nucleotide binding] 158190010177 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 158190010178 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 158190010179 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 158190010180 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 158190010181 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 158190010182 Walker A/P-loop; other site 158190010183 ATP binding site [chemical binding]; other site 158190010184 Q-loop/lid; other site 158190010185 ABC transporter signature motif; other site 158190010186 Walker B; other site 158190010187 D-loop; other site 158190010188 H-loop/switch region; other site 158190010189 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 158190010190 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 158190010191 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 158190010192 TM-ABC transporter signature motif; other site 158190010193 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 158190010194 phosphate binding site [ion binding]; other site 158190010195 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 158190010196 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 158190010197 N- and C-terminal domain interface [polypeptide binding]; other site 158190010198 active site 158190010199 MgATP binding site [chemical binding]; other site 158190010200 catalytic site [active] 158190010201 metal binding site [ion binding]; metal-binding site 158190010202 xylulose binding site [chemical binding]; other site 158190010203 putative homodimer interface [polypeptide binding]; other site 158190010204 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 158190010205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190010206 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 158190010207 putative substrate translocation pore; other site 158190010208 PKD domain; Region: PKD; pfam00801 158190010209 Right handed beta helix region; Region: Beta_helix; pfam13229 158190010210 Right handed beta helix region; Region: Beta_helix; pfam13229 158190010211 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 158190010212 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 158190010213 tetramer interface [polypeptide binding]; other site 158190010214 heme binding pocket [chemical binding]; other site 158190010215 NADPH binding site [chemical binding]; other site 158190010216 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 158190010217 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 158190010218 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 158190010219 dimer interface [polypeptide binding]; other site 158190010220 PYR/PP interface [polypeptide binding]; other site 158190010221 TPP binding site [chemical binding]; other site 158190010222 substrate binding site [chemical binding]; other site 158190010223 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869 158190010224 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 158190010225 TPP-binding site [chemical binding]; other site 158190010226 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 158190010227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 158190010228 H+ Antiporter protein; Region: 2A0121; TIGR00900 158190010229 putative substrate translocation pore; other site 158190010230 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 158190010231 active site 158190010232 DNA polymerase IV; Validated; Region: PRK02406 158190010233 DNA binding site [nucleotide binding] 158190010234 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 158190010235 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 158190010236 ATP-grasp domain; Region: ATP-grasp_4; cl17255 158190010237 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 158190010238 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 158190010239 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158190010240 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158190010241 TSCPD domain; Region: TSCPD; cl14834 158190010242 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 158190010243 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 158190010244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 158190010245 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 158190010246 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 158190010247 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 158190010248 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 158190010249 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 158190010250 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 158190010251 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 158190010252 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 158190010253 Integrase core domain; Region: rve; pfam00665 158190010254 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 158190010255 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 158190010256 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 158190010257 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158190010258 hypothetical protein; Provisional; Region: PRK11820 158190010259 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 158190010260 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 158190010261 cytidylate kinase; Provisional; Region: PRK04182 158190010262 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 158190010263 CMP-binding site; other site 158190010264 The sites determining sugar specificity; other site 158190010265 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 158190010266 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 158190010267 substrate binding pocket [chemical binding]; other site 158190010268 chain length determination region; other site 158190010269 substrate-Mg2+ binding site; other site 158190010270 catalytic residues [active] 158190010271 aspartate-rich region 1; other site 158190010272 active site lid residues [active] 158190010273 aspartate-rich region 2; other site 158190010274 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 158190010275 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 158190010276 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 158190010277 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 158190010278 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 158190010279 active site 158190010280 metal binding site [ion binding]; metal-binding site 158190010281 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 158190010282 Domain of unknown function (DUF814); Region: DUF814; pfam05670 158190010283 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 158190010284 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 158190010285 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 158190010286 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 158190010287 Walker A/P-loop; other site 158190010288 ATP binding site [chemical binding]; other site 158190010289 Q-loop/lid; other site 158190010290 ABC transporter signature motif; other site 158190010291 Walker B; other site 158190010292 D-loop; other site 158190010293 H-loop/switch region; other site 158190010294 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 158190010295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 158190010296 ABC-ATPase subunit interface; other site 158190010297 dimer interface [polypeptide binding]; other site 158190010298 putative PBP binding regions; other site 158190010299 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 158190010300 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 158190010301 intersubunit interface [polypeptide binding]; other site 158190010302 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 158190010303 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 158190010304 4Fe-4S binding domain; Region: Fer4; cl02805 158190010305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 158190010306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 158190010307 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 158190010308 putative dimerization interface [polypeptide binding]; other site 158190010309 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 158190010310 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 158190010311 acyl-activating enzyme (AAE) consensus motif; other site 158190010312 putative AMP binding site [chemical binding]; other site 158190010313 putative active site [active] 158190010314 putative CoA binding site [chemical binding]; other site 158190010315 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 158190010316 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 158190010317 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 158190010318 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 158190010319 active site 158190010320 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 158190010321 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 158190010322 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 158190010323 nucleotide binding site [chemical binding]; other site 158190010324 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 158190010325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190010326 dimer interface [polypeptide binding]; other site 158190010327 conserved gate region; other site 158190010328 putative PBP binding loops; other site 158190010329 ABC-ATPase subunit interface; other site 158190010330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 158190010331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 158190010332 dimer interface [polypeptide binding]; other site 158190010333 conserved gate region; other site 158190010334 putative PBP binding loops; other site 158190010335 ABC-ATPase subunit interface; other site 158190010336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 158190010337 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 158190010338 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 158190010339 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 158190010340 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 158190010341 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 158190010342 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 158190010343 active site 158190010344 catalytic tetrad [active] 158190010345 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 158190010346 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 158190010347 active site 158190010348 ADP/pyrophosphate binding site [chemical binding]; other site 158190010349 dimerization interface [polypeptide binding]; other site 158190010350 allosteric effector site; other site 158190010351 fructose-1,6-bisphosphate binding site; other site 158190010352 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 158190010353 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 158190010354 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 158190010355 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 158190010356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 158190010357 DNA binding residues [nucleotide binding] 158190010358 dimerization interface [polypeptide binding]; other site 158190010359 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 158190010360 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 158190010361 putative dimer interface [polypeptide binding]; other site 158190010362 putative anticodon binding site; other site 158190010363 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 158190010364 homodimer interface [polypeptide binding]; other site 158190010365 motif 1; other site 158190010366 motif 2; other site 158190010367 active site 158190010368 motif 3; other site 158190010369 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 158190010370 Carbon starvation protein CstA; Region: CstA; pfam02554 158190010371 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 158190010372 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 158190010373 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158190010374 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 158190010375 acyl-activating enzyme (AAE) consensus motif; other site 158190010376 putative AMP binding site [chemical binding]; other site 158190010377 putative active site [active] 158190010378 putative CoA binding site [chemical binding]; other site 158190010379 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 158190010380 ArsC family; Region: ArsC; pfam03960 158190010381 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 158190010382 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 158190010383 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 158190010384 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 158190010385 acyl-activating enzyme (AAE) consensus motif; other site 158190010386 acyl-activating enzyme (AAE) consensus motif; other site 158190010387 putative AMP binding site [chemical binding]; other site 158190010388 putative active site [active] 158190010389 putative CoA binding site [chemical binding]; other site 158190010390 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 158190010391 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 158190010392 DJ-1 family protein; Region: not_thiJ; TIGR01383 158190010393 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 158190010394 conserved cys residue [active] 158190010395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 158190010396 hypothetical protein; Provisional; Region: PRK13663 158190010397 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 158190010398 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 158190010399 active site 158190010400 metal binding site [ion binding]; metal-binding site 158190010401 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 158190010402 Rrf2 family protein; Region: rrf2_super; TIGR00738 158190010403 Transcriptional regulator; Region: Rrf2; pfam02082 158190010404 Rrf2 family protein; Region: rrf2_super; TIGR00738 158190010405 Transcriptional regulator; Region: Rrf2; pfam02082 158190010406 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 158190010407 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 158190010408 dimer interface [polypeptide binding]; other site 158190010409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 158190010410 catalytic residue [active] 158190010411 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 158190010412 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 158190010413 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 158190010414 minor groove reading motif; other site 158190010415 helix-hairpin-helix signature motif; other site 158190010416 active site 158190010417 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 158190010418 NAD(P) binding pocket [chemical binding]; other site 158190010419 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 158190010420 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 158190010421 active site 158190010422 catalytic residues [active] 158190010423 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 158190010424 Transcriptional regulators [Transcription]; Region: GntR; COG1802 158190010425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 158190010426 DNA-binding site [nucleotide binding]; DNA binding site 158190010427 FCD domain; Region: FCD; pfam07729 158190010428 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 158190010429 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 158190010430 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 158190010431 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 158190010432 nucleoside/Zn binding site; other site 158190010433 dimer interface [polypeptide binding]; other site 158190010434 catalytic motif [active] 158190010435 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 158190010436 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 158190010437 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 158190010438 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 158190010439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 158190010440 Coenzyme A binding pocket [chemical binding]; other site 158190010441 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 158190010442 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 158190010443 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 158190010444 Na binding site [ion binding]; other site